Profil

Hubert Philippe

Département de pharmacie > Chimie analytique

Conseiller du Recteur

Vice-doyen à l'enseignement (Médecine)

CIRM

See author's contact details
ORCID
0000-0003-4941-3052

Main Research Fields
Pharmacy, pharmacology & toxicology
Chemistry
Biochemistry, biophysics & molecular biology
Mathematics
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Main Keywords
Validation; Design Space; validation; Raman spectroscopy; Process Analytical Technology;
Main Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Centre Interfacultaire de Recherche du Médicament - CIRM
C.I.R.M.
CIRM - Service de Chimie Analytique
Centre Interfacultaire de Recherche du Médicament
Main Co-authors
Ziemons, Eric 
Crommen, Jacques 
Rozet, Eric 
Chiap, Patrice 
Marini Djang'Eing'A, Roland 

Publications (total 1092)

The most downloaded
19660 downloads
Dispas, A., Mbinze Kindenge, J., Lecomte, F., Marini Djang'Eing'A, R., & Hubert, P. (2015). Qualification de l'équipement. (ULiège - Université de Liège, PHIN2023-1 Analyse des médicaments - Méthodes d'analyse pharmaceutique et biopharmaceutique partim a : validation et qualification de l'appareillage). https://hdl.handle.net/2268/187472
The most cited
379 citations (SCOPUS)
Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., & Valat, L. (15 November 2004). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - part I. Journal of Pharmaceutical and Biomedical Analysis, 36 (3), 579-586. doi:10.1016/j.jpba.2004.07.027 https://hdl.handle.net/2268/6169

Elderderi, S., Sacre, P.-Y., Wils, L., Chourpa, I., Elbashir, A. A., Hubert, P., Byrne, H. J., Boudesocque-Delaye, L., Ziemons, E., & Bonnier, F. (27 July 2022). Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents. Molecules, 27 (15), 4819. doi:10.3390/molecules27154819
Peer Reviewed verified by ORBi

Hamla, S., Sacre, P.-Y., Derenne, A., Cowper, B., Goormaghtigh, E., Hubert, P., & Ziemons, E. (09 July 2022). A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept. Molecules, 27 (14), 4405. doi:10.3390/molecules27144405
Peer Reviewed verified by ORBi

Ciza Hamuli, P., Sacre, P.-Y., Waffo Tchounga, C. A., Kimbeni, T. M., Masereel, B., Hubert, P., Ziemons, E., & Marini Djang'Eing'A, R. (July 2022). Comparison of several strategies for the deployment of a multivariate regression model on several handheld NIR instruments. Application to the quality control of medicines. Journal of Pharmaceutical and Biomedical Analysis, 215, 114755. doi:10.1016/j.jpba.2022.114755
Peer Reviewed verified by ORBi

Waffo Tchounga, C. A.* , Sacre, P.-Y., Ciza Hamuli, P., Ngono Rose, Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R.*. (07 June 2022). DD-SIMCA and PLS regression models applied to NIR spectroscopy for identification and assay of ciprofloxacin tablets. Paper presented at Congrès de Chimiométrie 2022, Brest, France.
Peer reviewed

Hamla, S., Sacre, P.-Y., Derenne, A., Derfoufi, K.-M., Cowper, B., I. Butré, C., Delobel, A., Goormaghtigh, E., Hubert, P., & Ziemons, E. (07 June 2022). Is SVM a black box? Visualization and interpretation of SVR models to analyze glycosylation in pharmaceutical proteins (mAbs, Fc) based on infrared spectroscopy FT-IR. Poster session presented at Congrès CHIMIOMETRIE, Brest, France.
Peer reviewed

Van Laethem, T., Kumari, P., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (June 2022). A pharmaceutical-related molecules dataset for reversed-phase chromatography retention time prediction built on combining pH and gradient time conditions. Data in Brief, 42, 108017. doi:10.1016/j.dib.2022.108017
Peer Reviewed verified by ORBi

Widart, J., Beauvois, V., LAMBERT, V., Maesen, P., & Hubert, P. (2022). Rapport d'activités RQLab - Année 2021. autre.

De Bleye, C., Lebrun, P., Sacre, P.-Y., Laurent, A., Kemik, K., Hubert, C., Hubert, P., & Ziemons, E. (20 May 2022). Optimisation robuste de la synthèse de nanoparticules d’argent en vue de leur utilisation en spectroscopie Raman exaltée de surface. Paper presented at GFSV 2022, Nivelles, Belgium.

Hamla, S., Sacre, P.-Y., Derenne, A., Goormaghtigh, E., Hubert, P., & Ziemons, E. (18 May 2022). Identification of monoclonal antibodies based on Drop-Coating Deposition Raman imaging (DCDR) combined with Multivariate Curve Resolution Alternating Least Square (MCR-ALS) analysis. Poster session presented at Journées du Groupe Français de Spectroscopie Vibrationnelle, Nivelles, Belgium.
Peer reviewed

Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (2022). Applications de la spectroscopie vibrationnelle pour le contrôle qualité des médicaments de qualité inférieure et falsifiés. Paper presented at Cours sur la falsification des médicaments, Paris, France.

Avohou, T. H.* , Sacre, P.-Y., Hubert, P., & Ziemons, E. (04 March 2022). Interpretable One-Class Classification of Raman Spectra Using Prediction Bands Estimated by Wavelet Regression. Analytical Chemistry, 94, 4183-4191. doi:10.1021/acs.analchem.1c04098
Peer Reviewed verified by ORBi

Coic, L., Sacre, P.-Y., Dispas, A., De Bleye, C., Fillet, M., Ruckebusch, C., Hubert, P., & Ziemons, E. (March 2022). Selection of essential spectra to improve the multivariate curve resolution of minor compounds in complex pharmaceutical formulations. Analytica Chimica Acta, 1198, 339532. doi:10.1016/j.aca.2022.339532
Peer Reviewed verified by ORBi

Hamla, S., Sacre, P.-Y., Derenne, A., Derfoufi, K.-M., Cowper, B., Butré, C. I., Delobel, A., Goormaghtigh, E., Hubert, P., & Ziemons, E. (2022). A new alternative tool to analyse glycosylation in pharmaceutical proteins based on infrared spectroscopy combined with nonlinear support vector regression. Analyst. doi:10.1039/D1AN00697E
Peer Reviewed verified by ORBi

Sacre, P.-Y., Waffo Tchounga, C. A., Ciza Hamuli, P., Avohou, T. H., De Bleye, C., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (02 February 2022). Applications of vibrational spectroscopy and imaging for the analysis of substandard or falsified medicines. Paper presented at CIRM DAY.

Horne, J., De Bleye, C., Laurent, A., Kemik, K., Hubert, C., Hubert, P., & Ziemons, E. (02 February 2022). COMBINING CHARACTERIZATION TOOLS FOR SCREENING OF CRITICAL PARAMETERS LEADING TO REPRODUCIBLE SYNTHESIS OF SILVER NANOPARTICLES. Paper presented at CIRMday 2022, Liege, Belgium.

Van Laethem, T., Kumari, P., Fillet, M., Hubert, P., Hubert, C., & Sacre, P.-Y. (02 February 2022). Elaboration of a strategy for in silico screening for reversed-phase liquid chromatography method development. Paper presented at CIRM-day 2022, Liège, Belgium.

Kagheni Mbayahi, E., Kitasuvirwa, W., Ciza Hamuli, P., Waffo Tchounga, C. A., Hubert, P., Sacre, P.-Y., Ziemons, E., Kalonji, N. J.-B., & Marini Djang'Eing'A, R. (02 February 2022). Quality control of anti-infective medicines : case of ciprofloxacin and metronidazole formulations in Butembo. Poster session presented at CIRM Day 2022, Liège, Belgium.

Sacre, P.-Y., Alaoui Mansouri, M., De Bleye, C., Coic, L., Hubert, P., & Ziemons, E. (25 January 2022). Evaluation of distributional homogeneity of pharmaceutical formulation using laser direct infrared imaging. International Journal of Pharmaceutics, 612 (121373). doi:10.1016/j.ijpharm.2021.121373
Peer Reviewed verified by ORBi

Deidda, R., Dispas, A., De Bleye, C., Hubert, P., & Ziemons, E. (2022). Critical review on recent trends in cannabinoid determination on cannabis herbal samples: From chromatographic to vibrational spectroscopic techniques. Analytica Chimica Acta, 1209, 339184. doi:10.1016/j.aca.2021.339184
Peer Reviewed verified by ORBi

Jambo, H., Dispas, A., Hubert, C., Lecomte, F., Ziemons, E., & Hubert, P. (2022). Generic SFC-MS methodology for the quality control of vitamin D3 oily formulations. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2021.114492
Peer Reviewed verified by ORBi

Jambo, H., Hubert, P., & Dispas, A. (2022). Supercritical Fluid Chromatography for pharmaceutical quality control: current challenges and perspectives. TrAC: Trends in Analytical Chemistry. doi:10.1016/j.trac.2021.116486
Peer Reviewed verified by ORBi

Sacre, P.-Y., De Bleye, C., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (2022). Interest of Raman spectroscopy for the detection and analysis of poor-quality medicines. Paper presented at 9th International Conference on Advanced Applied Raman Spectroscopy (RamanFest2022), Paris, France.
Editorial reviewed

Dispas, A., Hubert, C., & Hubert, P. (December 2021). Perspective: What constitutes a quality paper in drug analysis? Talanta Open, 4, 100054. doi:10.1016/j.talo.2021.100054
Peer Reviewed verified by ORBi

Coic, L., Sacre, P.-Y., De Bleye, C., Hubert, P., & Ziemons, E. (25 November 2021). La microscopie moyen infrarouge: Théorie et applications dans le domaine pharmaceutique et biomédical. Paper presented at Journées GFSV 2021: Imagerie et Spectroscopie Vibrationnelle.

Van Laethem, T., Kumari, P., Fillet, M., Hubert, P., Hubert, C., & Sacre, P.-Y. (05 October 2021). Modélisation du temps de rétention de petites molécules pharmaceutiques en chromatographie liquide en phase inverse basée sur le QSRR et les surfaces de réponse. Poster session presented at 14ème Congrès Francophone sur les Sciences Séparatives et les Couplages de l'AFSEP, Paris, France.
Peer reviewed

Emonts, P., Avohou, T. H., Hubert, P., Ziemons, E., Fillet, M., & Dispas, A. (October 2021). Development of a sensitive MEKC-LIF method for the analysis of synthetic cathinones and amphetamines Paul Emonts. Poster session presented at SEP2021, Paris, France.

Emonts, P., Avohou, T. H., Hubert, P., Ziemons, E., Fillet, M., & Dispas, A. (October 2021). Optimization of a robust and reliable FITC labeling process for CE-LIF analysis of pharmaceutical compounds using design of experiments strategy. Journal of Pharmaceutical and Biomedical Analysis, 205, 114304. doi:10.1016/j.jpba.2021.114304
Peer Reviewed verified by ORBi

Deidda, R., Avohou, T. H., Dumont, E., Hubert, C., Hubert, P., De Bleye, C., & Ziemons, E. (2021). Application of the analytical quality by design principles to the development of a qualitative surface-enhanced Raman scattering method: A proof of concept. Journal of Raman Spectroscopy. doi:10.1002/jrs.6249
Peer Reviewed verified by ORBi

Dispas, A., Guillarme, D., Clarke, A., Veuthey, J.-L., & Hubert, P. (September 2021). La chromatographie en phase supercritique, une alternative aux méthodes normées ? Un voyage quantitatif de la répétabilité à la reproductibilité. Paper presented at SEP 2021, Paris, France.

Dispas, A., Clarke, A., Grand-Guillaume Perrenoud, A., Losacco, L. G., Veuthey, J.-L., Gros, Q., Molineau, J., Noireau, A., West, C., Salafia, F., Zoccali, M., Mondello, L., Guillen, A., Wang, J., Zhang, K., Jochems, P., Schad, G., Nakajima, K., Horie, S., & Hubert, P. (September 2021). Interlaboratory study of a supercritical fluid chromatography method for the determination of pharmaceutical impurities: Evaluation of multi-systems reproducibility. Journal of Pharmaceutical and Biomedical Analysis, 203, 114206. doi:10.1016/j.jpba.2021.114206
Peer Reviewed verified by ORBi

Ciza Hamuli, P., Sacre, P.-Y., Kanyonyo, M. R., Waffo Tchounga, C. A., Borive, M. A., Coic, L., Mbinze, J., Hubert, P., Ziemons, E., & Marini Djang'Eing'A, R. (August 2021). Application of NIR handheld transmission spectroscopy and chemometrics to assess the quality of locally produced antimalarial medicines in the Democratic Republic of Congo. Talanta Open, 3, 100025. doi:10.1016/j.talo.2020.100025
Peer Reviewed verified by ORBi

Kasemiire, A., Avohou, T. H., De Bleye, C., Sacre, P.-Y., Dumont, E., Hubert, P., & Ziemons, E. (11 June 2021). Design of experiments and design space approaches in the pharmaceutical bioprocess optimization. European Journal of Pharmaceutics and Biopharmaceutics, 166 (September), 144-154. doi:10.1016/j.ejpb.2021.06.004
Peer Reviewed verified by ORBi

Sacre, P.-Y., De Bleye, C., Hubert, P., & Ziemons, E. (2021). PAT Applications of NIR Spectroscopy in the Pharmaceutical Industry. In R. A. Crocombe, P. E. Leary, & B. W. Kammrath (Eds.), Portable Spectroscopy and Spectrometry, Volume 1, Technologies and Instrumentation (pp. 67-82). Wiley.
Peer reviewed

Van Laethem, T., Kumari, P., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (24 May 2021). Adaptive response surface model of small pharmaceutical compounds in reverse phase liquid chromatography. Paper presented at CIRM-day 2021, Liège, Belgium.

Dispas, A., Guillarme, D., & Hubert, P. (20 May 2021). LA SFC, UNE ALTERNATIVE AUX MÉTHODES NORMÉES DE LA PHARMACOPÉE EUROPÉENNE ? Paper presented at La SFC, une vraie alternative ?, Lyon, France.

Deidda, R.* , Coppey, F.* , Damergi, D., Schelling, C., Coic, L., Veuthey, J.-L., Sacre, P.-Y., De Bleye, C., Hubert, P., Esseiva, P., & Ziemons, E. (2021). New perspective for the in-field analysis of cannabis samples using handheld near-infrared spectroscopy: A case study focusing on the determination of Δ9-tetrahydrocannabinol. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2021.114150
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Coic, L., Sacre, P.-Y., Dispas, A., De Bleye, C., Fillet, M., Ruckebusch, C., Hubert, P., & Ziemons, E. (22 April 2021). Pixel-based Raman hyperspectral identification of complex pharmaceutical formulations. Analytica Chimica Acta, 1155, 338361. doi:10.1016/j.aca.2021.338361
Peer Reviewed verified by ORBi

Dumont, E., De Bleye, C., Rademaker, G., Coic, L., Horne, J., Sacre, P.-Y., Peulen, O., Hubert, P., & Ziemons, E. (01 March 2021). Development of a prototype device for near real-time surface-enhanced Raman scattering monitoring of biological samples. Talanta, 224, 121866. doi:10.1016/j.talanta.2020.121866
Peer Reviewed verified by ORBi

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (03 February 2021). Using prediction bands for near-infrared spectra for authentication and verification of drug products. Paper presented at eChimiométrie 2021.

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (03 February 2021). Quantitative structure-retention relationship modelling of small pharmaceutical compounds in reverse phase liquid chromatography. Paper presented at Chimiométrie.

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (03 February 2021). Quantitative structure-retention relationship modelling of small pharmaceutical compounds in reverse phase liquid chromatography. Paper presented at e-CHIMIOMETRIE 2021.
Peer reviewed

Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (01 February 2021). A probabilistic class-modelling method based on prediction bands for functional spectral data: Methodological approach and application to near-infrared spectroscopy. Analytica Chimica Acta, 1144, 130-149. doi:10.1016/j.aca.2020.11.039
Peer Reviewed verified by ORBi

Alaoui Mansouri, M., Ziemons, E., Sacre, P.-Y., kharbach, M., Barra, I., Cherrah, Y., Hubert, P., Marini Djang'Eing'A, R., & Bouklouze, A. (26 January 2021). Classification of polymorphic forms of fluconazole in pharmaceuticals by FT-IR and FT-NIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 196, 113022. doi:10.1016/j.jpba.2021.113922
Peer Reviewed verified by ORBi

Emonts, P., Servais, A.-C., Ziemons, E., Hubert, P., Fillet, M., & Dispas, A. (January 2021). Development of a sensitive MEKC‐LIF method for synthetic cathinones analysis. Electrophoresis, 0, 1-8. doi:10.1002/elps.202000331
Peer Reviewed verified by ORBi

TEBANDITE KASAI, E., ALWORONG'A OPARA, J.-P., BATINA AGASA, S., GULBIS, B., APIO UVOYA, N., BOSENGE NGUMA, J. D., KASONGO MALOBA, P., Hubert, P., Etienne, A.-M., & Marini Djang'Eing'A, R. (2020). Acceptabilité du dépistage néonatal de la drépanocytose au cours de la pandémie au COVID-19 à Kisangani, en République Démocratique du Congo. Pan African Medical Journal. doi:10.11604/pamj.2020.37.299.26654
Peer reviewed

Deidda, R., Schelling, C., Roussel, J.-M., Dispas, A., De Bleye, C., Ziemons, E., Hubert, P., & Veuthey, J.-L. (2020). The analysis of cannabinoids in cannabis samples bysupercritical fluid chromatography and ultra-high-performanceliquid chromatography: A comparison study. Analytical Science Advances, 1-13. doi:10.1002/ansa.202000091
Peer Reviewed verified by ORBi

Coppey, F., Bécue, A., Sacre, P.-Y., Ziemons, E., Hubert, P., & Esseiva, P. (10 September 2020). Providing illicit drugs results in five seconds using ultra-portable NIR technology: An opportunity for forensic laboratories to cope with the trend toward the decentralization of forensic capabilities. Forensic Science International, 317, 110498. doi:10.1016/j.forsciint.2020.110498
Peer Reviewed verified by ORBi

Coic, L., Sacre, P.-Y., Dispas, A., Dumont, E., Horne, J., De Bleye, C., Fillet, M., Hubert, P., & Ziemons, E. (01 July 2020). Evaluation of the analytical performances of two Raman handheld spectrophotometers for pharmaceutical solid dosage form quantitation. Talanta, 214, 120888. doi:10.1016/j.talanta.2020.120888
Peer Reviewed verified by ORBi

Dumont, E., De Bleye, C., Haouchine, M., Coic, L., Sacre, P.-Y., Hubert, P., & Ziemons, E. (05 June 2020). Effect of the functionalisation agent on the surface-enhanced Raman scattering (SERS) spectrum: Case study of pyridine derivatives. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 233, 118180. doi:10.1016/j.saa.2020.118180
Peer Reviewed verified by ORBi

De Bleye, C., Fontaine, M., Dumont, E., Sacre, P.-Y., Hubert, P., Theys, N., & Ziemons, E. (15 April 2020). Raman imaging as a new analytical tool for the quality control of the monitoring of osteogenic differentiation in forming 3D bone tissue. Journal of Pharmaceutical and Biomedical Analysis, 186, 113319. doi:10.1016/j.jpba.2020.113319
Peer Reviewed verified by ORBi

Lecomte, F.* , Aerts, J.* , Plenevaux, A., Defraiteur, C., Chappuis-Hugon, F., Rozet, E., CHIAP, P., Luxen, A., Pichon, V., Hubert, P.* , & Hubert, C.*. (20 February 2020). Performance evaluation of a MIP for the MISPE-LC determination of p-[18F]MPPF and a potential metabolite in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 180. doi:10.1016/j.jpba.2019.113015
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (18 February 2020). A one-class Classification method based on depth statistics : applications to process analytical technology (PAT) and detection of counterfeited drugs. Paper presented at Weekly CIRM Scientific Seminar, Liege, Belgium.

Marini Djang'Eing'A, R., MBINZE KINDENGE, J., TAKAISI KIKUNI, P., LUNGUNYA METILA, O., & Hubert, P. (14 February 2020). Falsification des médicaments et résistance aux antimicrobiens. Paper presented at Le rôle des universités face aux défis de santé en Afrique centrale, Kinshasa, Congo - Kinshasa.

Beauvois, V., Widart, J., Hubert, P., Dumont, F., & Janssen, E. (2020). Rapport d'activité RQLab Année 2019.

Ciza Hamuli, P., Sacre, P.-Y., Kanyonyo, M., Waffo Tchounga, C. A., Coic, L., mbinze, J., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (28 January 2020). Application of vibrationnal spectroscopy and chemometrics to access the quality of Locally produced antimalarial medicines in the Democratic Republic of Congo. Poster session presented at Conférence Chimiométrie 2020, ULiège - Université de Liège, Belgium.

Hubert, C., Deidda, R., Dispas, A., Van Laethem, T., Zhao, X., Lebrun, P., & Hubert, P. (28 January 2020). Implementing principles of Analytical Quality by Design (AQbD) for method development in quality control environment. Paper presented at 16th International Symposium on Hyphenated Techniques in Chromatography and Separation technology, Ghent, Belgium.

Deidda, R., Damergi, D., Coppey, F., De Bleye, C., Coic, L., Sacre, P.-Y., Hubert, P., Ziemons, E., Esseiva, P., & Veuthey, J.-L. (28 January 2020). Handheld Near Infrared spectroscopy for cannabis analysis: from the analytical problem to the chemometric solution. Paper presented at Chimiométrie 2020, Liège, Belgium.

Deidda, R., El Morabit, L., De Bleye, C., Sacre, P.-Y., Boccard, J., Hubert, P., Ziemons, E., Vernaz, N., Tobolkina, E., Veuthey, J.-L., & Rudaz, S. (28 January 2020). Near infrared spectroscopy as a screening technique for the quality control of antiretroviral drugs for HIV treatment in Swiss prisons. Poster session presented at Chimiométrie 2020, Liège, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (28 January 2020). A probabilistic class-modelling method based on Bayesian prediction intervals for functional depth (vs outlyingness) statistics. Paper presented at Chimiométrie 2020, Liège, Belgium.

Hamla, S., Sacre, P.-Y., Derenne, A., Goormaghtigh, E., Hubert, P., & Ziemons, E. (28 January 2020). Partial least squares (PLS) vs support vector machine (SVM) vs artificial neural network (ANN). Which model is the best performer in predicting monosaccharide content of pharmaceutical proteins based on their FT-IR spectrum? Poster session presented at Conférence Chimiométrie 2020, Liège, Belgium.

Cailletaud, J., De Bleye, C., Dumont, E., Sacre, P.-Y., Gut, Y., Leblanc, N., Letellier, P., Ginot, Y.-M., Hubert, P., & Ziemons, E. (25 January 2020). Detection of low dose of piroxicam polymorph in pharmaceutical tablets by surface-enhanced Raman chemical imaging (SER-CI) and multivariate analysis. International Journal of Pharmaceutics, 574, 118913. doi:10.1016/j.ijpharm.2019.118913
Peer Reviewed verified by ORBi

Alaoui Mansouri, M., Sacre, P.-Y., Coic, L., De Bleye, C., Dumont, E., Bouklouze, A., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (15 January 2020). Quantitation of Active Pharmaceutical Ingredient through the Packaging Using Raman Handheld Spectrophotometers: A Comparison Study. Talanta, 207, 120306. doi:10.1016/j.talanta.2019.120306
Peer Reviewed verified by ORBi

Mavungu Landu, D. J., Marini Djang'Eing'A, R., Hubert, P., Frederich, M., Michel, B., Gretry, L., Messina Ndzomo, J. P., Bruyère, O., Reginster, J.-Y., & Manzambi Kuwekita, J. (2020). Les déterminants de l’accès à des médicaments antipaludiques de qualité en territoires périurbains africains : résultats d’une enquête menée à Kinshasa (Congo). Journal d’Épidémiologie et de Santé Publique, 21, 85-100.
Peer reviewed

Mavungu Landu, D. J., Frederich, M., Manzambi Kuwekita, J., Bongo-Pasi Nswe, C., Mbinze Kindenge, J., Liégeois, S., Kalenda Tshilombo, N., Mineze Kwete Minga, Ciza Hamuli, P., Hubert, P., & Marini Djang'Eing'A, R. (2020). Quality of antimalarials in Kinshasa peri-urban areas with regard to local pharmaceutical legislation and regulation. International Health, 12 (4), 253–263. doi:10.1093/inthealth/ihz070
Peer reviewed

Coic, L., Sacre, P.-Y., Dispas, A., Dumont, E., De Bleye, C., Fillet, M., Hubert, P., & Ziemons, E. (January 2020). How to analyse big data in hyperspectral imaging? Application for the elucidation of medicine composition. Poster session presented at Chimiométrie 2020, Liège, Belgium.

Dispas, A., Emonts, P., Avohou, T. H., Ziemons, E., Hubert, P., & Fillet, M. (January 2020). Design of experiments approach to optimize FITC labeling process. Poster session presented at Chimiométrie 2020, Liège, Belgium.

Coic, L., Sacre, P.-Y., Dispas, A., Dumont, E., De Bleye, C., Fillet, M., Hubert, P., & Ziemons, E. (11 December 2019). Which tools can help to thwart “out of memory” issues during analysis of big data? Poster session presented at CIRM Day 2nd edition.

Dumont, E., De Bleye, C., Coic, L., Sacre, P.-Y., Hubert, P., & Ziemons, E. (11 December 2019). How to overcome the protein corona problem in surface-enhanced Raman scattering (SERS) analyses of cell culture media. Paper presented at 2nd CIRM Scientific Day, Liège, Belgium.

Dumont, E., De Bleye, C., Cailletaud, J., Coic, L., Sacre, P.-Y., Hubert, P., & Ziemons, E. (29 November 2019). A new way of overcoming the protein corona problem in surface-enhanced Raman scattering (SERS): the use of membrane filters. Poster session presented at Bioforum of BioLiege 2019, Liège, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (2019). Concept and prototype V4F for classification. Paper presented at Meeting for transfer of knowledge to Biion & Pharmalex, V4F, Mont Saint-Guilbert, Belgium.

Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (15 November 2019). Class-modelling methods based on 𝜷-expectation tolerance regions for functional spectral (NIR and Raman) data. Paper presented at Scientific Workshops, Pharmalex, Mont Sain-Guilbert, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (24 October 2019). Spectrophotomètres portables :l’analyse chimique à portée de tous? Paper presented at Liège Créative, Liege, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (2019). Logiciel Vibra4Fake 2020.

De Bleye, C., Cailletaud, J., Dumont, E., Sacré, P.-Y., Gut, Y., Ginot, Y.-M., Hubert, P., & Ziemons, E. (11 October 2019). Application of surface-enhanced Raman chemical imaging (SER-CI) to quantification in pharmaceutical tablets. American Pharmaceutical Review, 22 (6).

Clavaud, M., Lema-Martinez, C., Roggo, Y., Bigalke, M., Guillemain, A., Hubert, P., Ziemons, E., & Allmendinger, A. (24 September 2019). NIR modelling for moisture content determination based on DoE approach. Paper presented at Pharmaceutical freeze drying technology - PDA Exchange Series, Berlin, Germany.

Dumont, E., De Bleye, C., Cailletaud, J., Coic, L., Sacre, P.-Y., Hubert, P., & Ziemons, E. (17 September 2019). Analysing cells and culture media with surface-enhanced Raman scattering (SERS): how to overcome the serum protein problem? Paper presented at 30th International Symposium on Pharmaceutical & Biomedical Analysis - PBA, Tel-Aviv, Israel.

De Bleye, C., Fontaine, M., Sacre, P.-Y., Hubert, P., Theys, N., & Ziemons, E. (16 September 2019). Raman imaging as a new analytical tool for the quality control of the monitoring of osteogenic differentiation in forming 3D bone tissue. Paper presented at 30th International Symposium on Pharmaceutical and Biomedical Analysis, Tel Aviv, Israel.

Beghuin, D., Dumont, E., Emeraud, T., Hubert, P., & Ziemons, E. (02 September 2019). Full field Raman imaging applied to pharmaceutical and biomedical fields: Proof of concept. Paper presented at Full field Raman imaging workshop, Liege, Belgium.

Ciza Hamuli, P.* , Sacre, P.-Y.* , Waffo Tchounga, C., Coic, L., Avohou, T. H., Mbinze, J., Ngono, R., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (01 September 2019). Comparing the qualitative performances of handheld NIR and Raman spectrophotometers for the detection of falsified pharmaceutical products. Talanta, 202, 469-478. doi:10.1016/j.talanta.2019.04.049
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Clavaud, M., Lema-Martinez, C., Roggo, Y., Bigalke, M., Guillemain, A., Hubert, P., Ziemons, E., & Allmendinger, A. (2019). Near-infrared spectroscopy to determine residual moisture in freeze-dried products: Model generation by statistical design of experiments. Journal of Pharmaceutical Sciences. doi:10.1016/j.xphs.2019.08.028
Peer reviewed

Cailletaud, J., De Bleye, C., Gutt, Y., Bultel, L., Leblanc, N., Letellier, P., Ginot, Y.-M., Hubert, P., & Ziemons, E. (25 June 2019). Surface enhanced Raman imaging applied to quality control of solid dosage forms. Paper presented at 7th Annual Conference on Advanced Applied Raman Spectroscopy, Oxford, United Kingdom.

Ciza Hamuli, P., Sacre, P.-Y., Waffo Tchounga, C. A., Coic, L., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (14 June 2019). Identification of pharmaceutical products using Handheld NIR and Raman spectrophotometers. Paper presented at Journées Internationales de Recherche en Sciences de la Santé 2019, Lubumbashi, Congo - Brazzaville.

Coic, L.* , Sacre, P.-Y.* , Dispas, A., sakira, A. K., Fillet, M., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (01 June 2019). Comparison of hyperspectral imaging techniques for the elucidation of falsified medicines composition. Talanta, 198, 457-463. doi:10.1016/j.talanta.2019.02.032
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Alaoui Mansouri, M., Sacre, P.-Y., Coic, L., De Bleye, C., Dumont, E., Bouklouze, A., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (20 May 2019). COMPARATIVE STUDY OF ACTIVE PHARMACEUTICAL INGREDIENT QUANTITATION THROUGH THE PACKAGING USING HANDHELD SPECTROPHOTOMETERS BASED ON CONVENTIONAL AND SPATIALLY OFFSET RAMAN SCATTERING. Paper presented at 20th forum of Pharmaceutical Sciences, Brussels, Belgium.

Hamla, S., Sacre, P.-Y., Derenne, A., Goormaghtigh, E., Hubert, P., & Ziemons, E. (20 May 2019). QUALITATIVE AND QUANTITATIVE ANALYSIS OF N-GLYCANS PART OF PHARMACEUTICAL PROTEINS BY FT-IR SPECTROSCOPY. Paper presented at BSPS 20th forum of pharmaceutical sciences.

Deidda, R., Avohou, T. H., Jambo, H., Dispas, A., Orlandini, S., Hubert, P., Ziemons, E., & Hubert, C. (20 May 2019). Principles of Analytical Quality by Design for the development of quality control methods in a pharmaceutical context. Paper presented at 20th Forum of Pharmaceutical Sciences - BSPS, Brussels, Belgium.

Ciza Hamuli, P., Sacre, P.-Y., Waffo Tchounga, C. A., Coic, L., Avohou, T. H., mbinze, J., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (20 May 2019). Detection of falsified pharmaceutical products using Handheld NIR and Raman spectrophotometers. Paper presented at BSPS 2019 Forum of Pharmaceutical Sciences - May 20th 2019 - Brussels, Bruxelles, Belgium.

Coic, L., Sacre, P.-Y., Dispas, A., Fillet, M., Hubert, P., & Ziemons, E. (20 May 2019). HANDHELD RAMAN SPECTROSCOPY: AN ESSENTIAL TOOL TO TACKLE THE SUBSTANDARD MEDICINES ISSUE? Paper presented at BSPS 2019 Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Deidda, R.* , Sacre, P.-Y.* , Clavaud, M., Coic, L., Avohou, T. H., Hubert, P., & Ziemons, E. (May 2019). Vibrational spectroscopy in analysis of pharmaceuticals: Critical review of innovative portable and handheld NIR and Raman spectrophotometers. TrAC: Trends in Analytical Chemistry, 114, 251-259. doi:10.1016/j.trac.2019.02.035
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Deidda, R., Mignolet, M., Jambo, H., Dispas, A., Hubert, P., & Hubert, C. (26 March 2019). Développement d’une méthode SFC-MS pour le dosage de vitamines en matrice complexe : Application de la stratégie « Analytical Quality by Design ». Paper presented at 13ème Congrès Francophone sur les sciences séparatives et les couplages (SEP2019), Paris, France.

Hubert, C., Widart, J., Ziemons, E., & Hubert, P. (2019). Process Analysis: Maintenance, Reliability, and Training. In Encyclopedia of Analytical Science 3rd Edition. Elsevier. doi:10.1016/B978-0-12-409547-2.14530-5
Peer reviewed

Ziemons, E., Hubert, C., & Hubert, P. (2019). Process Analysis - Overview. In M. Miro, P. Worsfold (Ed.), A. Townshend (Ed.), & C. Poole (Ed.), Encyclopedia of Analytical Science (3rd Edition, pp. 1-7). Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-12-409547-2.14051-X
Peer reviewed

Deidda, R., Avohou, T. H., Kasemiire, A., Dumont, E., De Bleye, C., Hubert, P., Hubert, C., & Ziemons, E. (30 January 2019). Optimisation of a surface enhanced Raman scattering method using design of experiments and Bayesian design space modelling. Poster session presented at Chimiométrie XIX - 2019, Montpellier, France.

Deidda, R., Avohou, T. H., Baronti, R., Davolio, P. L., Pasquini, B., Del Bubba, M., Hubert, C., Hubert, P., Orlandini, S., & Furlanetto, S. (2019). Analytical quality by design: development and control strategy for a LC method to evaluate the cannabinoids content in cannabis olive oil extracts. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2019.01.032
Peer Reviewed verified by ORBi

Emonts, P., Penoy, N., Rocks, N., Piel, G., Fillet, M., Hubert, P., Ziemons, E., & Evrard, B. (19 January 2019). Update of the progresses and development prospects of the FEDER project Phare. Paper presented at CIRM seminars, Liege, Belgium.

Coic, L., Sacre, P.-Y., Avohou, T. H., Ciza, P., Marini Djang'Eing'A, R., Fillet, M., Hubert, P., & Ziemons, E. (01 January 2019). Authentication of falsified medicine tablets by handheld Raman spectroscopy class modeling. Paper presented at Chimiométrie 2019, Montpellier, France.

Deidda, R., Avohou, T. H., Orlandini, S., Baronti, R., Pasquini, B., Furlanetto, S., Hubert, P., & Hubert, C. (19 December 2018). Control strategy applied to a LC-DAD quality control method as part of the analytical quality by design approach: one year of routine use. Paper presented at 1st CIRM Scientific Day, Liège, Belgium.

Emonts, P., Dispas, A., Ninane, C. (Other coll.), Hubert, P. (Other coll.), Servais, A.-C. (Other coll.), Ziemons, E. (Other coll.), & Fillet, M. (Other coll.). (19 December 2018). Development and optimization of a derivatization protocol for phenethylamine compounds using FITC-CE-LIF method. Poster session presented at 1st CIRM Scientific Day, Liège, Belgium.

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (19 December 2018). SFC-MS for the quality control of cannabis: addressing the potential adulteration with synthetic cannabinoids. Paper presented at CIRM Day (1st edition).

Dumont, E., De Bleye, C., Cailletaud, J., Sacre, P.-Y., Humblet, S., Vandormael, D., Fleury-Frenette, K., Hubert, P., & Ziemons, E. (19 December 2018). Assessment of the Surface-Enhanced Raman Scattering (SERS) response of solid SERS substrates prepared by innovative techniques. Poster session presented at 1st CIRM Scientific Day, Liège, Belgium.

Coic, L., Sacre, P.-Y., Dispas, A., Fillet, M., Hubert, P., & Ziemons, E. (19 December 2018). Development of graphical user interface (GUI) for database building and for falsification applications. Paper presented at CIRM Day, Belgium.

De Bleye, C., Widart, J., Sacre, P.-Y., Hubert, P., & Ziemons, E. (19 December 2018). Vibra-Santé Hub. Poster session presented at 1st CIRM Scientific Day, Liège, Belgium.

Dispas, A., Marini Djang'Eing'A, R., Desfontaine, V., Veuthey, J.-L., Kotoni, D., Losacco, L. G., Clarke, A., Muscat Galea, C., Mangelings, D., Jocher, B. M., Regalado, E. L., Plachka, K., Novakova, L., Wuyts, B., François, I., Gray, M., Aubin, A. J., Tarafder, A., Cazes, M., & Hubert, P. (30 November 2018). First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities. Journal of Pharmaceutical and Biomedical Analysis, 161, 414-424. doi:10.1016/j.jpba.2018.08.042
Peer Reviewed verified by ORBi

Castiglione, V., Sacre, P.-Y., Cavalier, E., Hubert, P., GADISSEUR, R., & Ziemons, E. (16 November 2018). Raman chemical imaging, a new tool in kidney stone structure analysis: Case-study and comparison to Fourier Transform Infrared spectroscopy. Poster session presented at Joint Annual Meeting of the Royal Belgian Society of Laboratory Medicine and the Belgian Thyroid Club.

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (19 October 2018). SFC-MS as a preventive tool for the quality control of potentially adulterated cannabis with synthetic cannabinoids. Paper presented at SFC 2018, Strasbourg, France.

Guillarme, D., Dispas, A., Desfontaine, V., Hubert, P., & Veuthey, J.-L. (October 2018). The use of SFC from research and development to quality control laboratories: dream or reality? Paper presented at SFC 2018, Strasbourg, France.

Cailletaud, J., De Bleye, C., Dumont, E., Sacre, P.-Y., Gut, Y., Bultel, L., Ginot, Y.-M., Hubert, P., & Ziemons, E. (01 October 2018). Towards a spray-coating method for the detection of low-dose compounds in pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI). Talanta, 188, 584-592. doi:10.1016/j.talanta.2018.06.037
Peer Reviewed verified by ORBi

Dispas, A., Lebrun, P., Marini Djang'Eing'A, R., Desfontaine, V., Kotoni, D., Clarke, A., Veuthey, J.-L., Guillarme, D., & Hubert, P. (October 2018). Evaluation of measurement uncertainty: from SFC method development to inter-laboratory study. Poster session presented at SFC 2018, Strasbourg, France.

Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (12 September 2018). A novel probabilistic spectral matching strategy based on wavelets regression and Bayesian modeling for product identification and quality verification. Paper presented at 11th International Symposium on Drug Analysis and 29th International Symposium on Pharmaceutical and Biomedical Analysis, DA-PB, Leuven, Belgium.

Dumont, E., De Bleye, C., Cailletaud, J., Deidda, R., Sacre, P.-Y., Van Lerberghe, P.-B., Rogister, B., Hubert, P., & Ziemons, E. (11 September 2018). A simple and easy-to-implement SERS approach overcoming the nanoparticle stabilisation by serum proteins: application to dopamine and PC-12 cells. Paper presented at 11th International Symposium on Drug Analysis - 29th International Symposium on Pharmaceutical and Biomedical Analysis (DA-PBA 2018), Leuven, Belgium.

Clavaud, M., Sacre, P.-Y., Hubert, P., & Ziemons, E. (09 September 2018). Transfer of active pharmaceutical ingredients (API) Raman library from bench top towards handheld spectrometers. Paper presented at International Syposium DA-PBA 2018, Leuven, Belgium.

Cailletaud, J., De Bleye, C., Dumont, E., Sacre, P.-Y., Gut, Y., Ginot, Y.-M., Hubert, P., & Ziemons, E. (September 2018). Detection of low-dose of piroxicam polymorphs in pharmaceutical tablets by surface-enhanced Raman chemical imaging and multivariate analysis. Poster session presented at 11th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis, Leuven, Belgium.

Ciza Hamuli, P., Waffo Tchounga, C., Coic, L., Mbinze Kindenge, J., Ngono, R., Marini Djang'Eing'A, R., Hubert, P., Sacre, P.-Y., & Ziemons, E. (September 2018). Comparing the qualitative performances of handheld NIR and Raman spectrometers for the analysis of falsified pharmaceutical products. Poster session presented at 11th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis, Louvain, Belgium.

Dispas, A., Marini Djang'Eing'A, R., Desfontaine, V., Veuthey, J.-L., Kotoni, D., Clarke, A., Muscat Galea, C., Mangelings, D., Jocher, B. M., Regalado, E. L., Plachka, K., Novakova, L., Wuyts, B., François, I., Gray, M., Aubin, A. J., Tarafder, A., Cazes, M., Desvignes, C., & Hubert, P. (September 2018). Collaborative study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities. Paper presented at Drug Analysis - PBA 2018, Leuven, Belgium.

Deidda, R., Avohou, T. H., Orlandini, S., Baronti, R., Pasquini, B., Furlanetto, S., Hubert, P., & Hubert, C. (September 2018). Analytical Quality by Design: development and control strategy for a RP-HPLC method implemented in routine to evaluate the cannabinoids content in cannabis olive oil extracts. Poster session presented at International Symposium DA-BPA 2018, Leuven, Belgium.

Coic, L., Sacre, P.-Y., Avohou, T. H., Sakira, K., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Solving composition of falsified artemether/lumefantrine formulation by hyperspectral imaging. Poster session presented at DA-PBA 2018 11th International Symposium on Drug Analysis (DA 2018), 29th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2018).

Sacre, P.-Y., Coic, L., Avohou, T. H., Sakira, K., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Forensic formulation fingerprinting of falsified medicine by Raman hyperspectral imaging. Paper presented at Medicine Quality and Public Health 2018, Oxford, United Kingdom.

Sacre, P.-Y., Avohou, T. H., Lebrun, P., Coic, L., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Bayesian securing of the pharmaceutical supply chain. Paper presented at Medicine Quality and Public Health 2018, Oxford, United Kingdom.

Dumont, E., De Bleye, C., Cailletaud, J., Sacre, P.-Y., Van Lerberghe, P.-B., Rogister, B., Rance, G. A., Aylott, J. W., Hubert, P., & Ziemons, E. (15 August 2018). Development of a SERS strategy to overcome the nanoparticle stabilisation effect in serum-containing samples: Application to the quantification of dopamine in the culture medium of PC-12 cells. Talanta, 186, 8-16. doi:10.1016/j.talanta.2018.04.038
Peer Reviewed verified by ORBi

Kalenda Tshilombo, N., Ciza Hamuli, P., Mbinze Kindenge, J., Habyalimana, V., Kalenda T. Dibungi, Mavungu Landu, D. J., Mwamba Tsilumba, P., Hubert, P., & Marini Djang'Eing'A, R. (09 August 2018). Investigation of the Quality of Antibiotics-Based Amoxicillin for Monitoring of Some Different Medicine Markets of Democratic Republic of Congo. American Journal of Analytical Chemistry, 9, 366- 385. doi:10.4236/ajac.2018.98029
Peer reviewed

Castiglione, V., Sacre, P.-Y., CAVALIER, E., Hubert, P., GADISSEUR, R., & Ziemons, E. (03 August 2018). Raman Chemical Imaging, a new tool in kidney stone structure analysis: Case-study and comparison to Fourier Transform Infrared spectroscopy. PLoS ONE, 13 (8), 0201460. doi:10.1371/journal.pone.0201460
Peer Reviewed verified by ORBi

Deidda, R., Orlandini, S., Hubert, P., & Hubert, C. (July 2018). Risk-based approach for method development in pharmaceutical quality control context: A critical review. Journal of Pharmaceutical and Biomedical Analysis, 161, 110-121. doi:10.1016/j.jpba.2018.07.050
Peer Reviewed verified by ORBi

Alaoui Mansouri, M., Sacre, P.-Y., Ziemons, E., kharbach, M., Cherrah, Y., Hubert, P., Bouklouze, A., & Marini Djang'Eing'A, R. (26 June 2018). CLASSIFICATION OF FLUCONAZOLE API POLYMORPHIC FORMS IN PHARMACEUTICAL PRODUCTS BY ASSOCIATING FTIR, NIR AND RAMAN TO PLS-DA. Poster session presented at Chemometrics in analytical chemistry XVII, Halifax, Canada.

Jambo, H., Hubert, C., & Hubert, P. (21 June 2018). Comment garantir la fiabilité de vos futurs résultats ? Paper presented at CCVS Validation de méthodes, Rouen, France.

Nguyen, T. D., Dortu, F., Dispas, A., Hubert, P., Ziemons, E., & Hernandez, Y. (28 May 2018). Terahertz hyper-spectral imaging of lab-prepared versus commercial paracetamol tablets and potential applications. Proceedings of SPIE: The International Society for Optical Engineering, 1067731, 1-7. doi:10.1117/12.2307648
Peer reviewed

Dumont, E., De Bleye, C., Cailletaud, J., Deidda, R., Sacre, P.-Y., Hubert, P., & Ziemons, E. (24 May 2018). About the use of surface-enhanced Raman scattering to monitor the cellular release of neurotransmitters. Paper presented at 11e Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique, Liège, Belgium.

Hubert, P. (18 May 2018). Vers une maîtrise intégrée des risques analytiques. Paper presented at Chaire Francqui 2017-2018, Bruxelles, Belgium.

Dumont, E., De Bleye, C., Cailletaud, J., Deidda, R., Sacre, P.-Y., Hubert, P., & Ziemons, E. (17 May 2018). Investigation of solid surface-enhanced Raman scattering (SERS) substrates for the quantification of dopamine in cell culture media. Poster session presented at Bioforum of BioLiège 2018, Liège, Belgium.

De Bleye, C., Cailletaud, J., Deidda, R., Dumont, E., Hubert, P., & Ziemons, E. (16 May 2018). Application of surface-enhanced Raman spectroscopy (SERS) in the biological and the pharmaceutical fields: state of the art and new perspectives. Paper presented at Séminaire mensuel du CIRM, Liège, Belgium.

Coic, L., Castiglione, V., Sacre, P.-Y., Hubert, P., GADISSEUR, R., CAVALIER, E., & Ziemons, E. (May 2018). Elucidation de la structure de la lithiase urinaire par imagerie IR-TF. Poster session presented at 11èmes journées scientifiques du Réseau Français de Métabolomique et Fluxomique, Liege, Belgium.

Nguyen, D., Dortu, F., Dispas, A., Hubert, P., Ziemons, E., & Hernandez, Y. (25 April 2018). Terahertz hyperspectral imaging of lab-prepared versus commercial paracetamol tablets and potential applications. Poster session presented at SPIE Photonics Europe, Strasbourg, France.

Dispas, A., Avohou, T. H., Lebrun, P., Hubert, P., & Hubert, C. (April 2018). ‘Quality by Design’ approach for the analysis of impurities in pharmaceutical drug products and drug substances. TrAC: Trends in Analytical Chemistry, 101, 24-33. doi:10.1016/j.trac.2017.10.028
Peer Reviewed verified by ORBi

Dumont, E., De Bleye, C., Cailletaud, J., Sacre, P.-Y., Hubert, P., & Ziemons, E. (2018). Development of a surface-enhanced Raman scattering strategy to quantify dopamine in cell culture media. (ULiège - Université de Liège, LANG5002-1 Advanced English for Biomedical Science 2).

Djellouli, O., Rozet, E., Dahmani, B., & Hubert, P. (21 March 2018). Compromise in uncertainty estimation by modelling and validation approaches for an HPLC-UV method for measurement of biochemical indicators of vitamins A and E. Analyst, 143, 1492-1501. doi:10.1039/c7an01804e
Peer Reviewed verified by ORBi

Hubert, P. (16 March 2018). Assurance Qualité et Recherche, est-ce compatible? Paper presented at Chaire Francqui 2017-2018, Bruxelles, Belgium.

Hubert, P. (08 March 2018). Tout ce que vous avez toujours voulu savoir sur les faux médicaments. Paper presented at Chaire Francqui 2017-2018, Bruxelles, Belgium.

Salvé, M., Avohou, T. H., Monbaliu, J.-C., Lebrun, P., Lemaire, C., Damblon, C., De Tullio, P., Hubert, P., Hustinx, R., & Luxen, A. (12 February 2018). NOTA‐PRGD2 and NODAGA‐PRGD2: Bioconjugation, characterization, radiolabelling, and design space. Journal of Labelled Compounds and Radiopharmaceuticals, 61, 487-500. doi:10.1002/jlcr.3613
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., KIKUNI TAKAISI, P., Masereel, B., & Hubert, P. (2018). CRÉATION D’UN CENTRE D’EXCELLENCE EN ASSURANCE ET CONTRÔLE DE QUALITÉ DES MÉDICAMENTS ET PRODUITS DE SANTÉ. (Rapport annuel N°2). Liège, Belgium: ULiège - Université de Liège.

Ciza Hamuli, P., Mbinze Kindenge, J., Sacre, P.-Y., Marini Djang'Eing'A, R., & Hubert, P. (31 January 2018). Développement d’une méthode générique proche infrarouge (PIR) dans le contrôle qualité et la contrefaçon des médicaments. Poster session presented at 3èmes Journées Médicales, Pharmaceutiques et Odontologiques de Ouagadougou, Ouagadougou, Burkina Faso.

Marini Djang'Eing'A, R., Mavungu Landu, D. J., Sakira, A. K., Sacre, P.-Y., Kalenda Tshilombo, N., & Hubert, P. (2018). Les risques sociétaux liés aux médicaments de qualité inférieure. In Book of Abstracts - 3ème JMPO - Université de Ouaga 1 Pr Ki Zerbo.
Peer reviewed

Avohou, T. H., Cailletaud, J., Clavaud, M., Coic, L., De Bleye, C., Deidda, R., Dumont, E., Sacre, P.-Y., Hubert, P., & Ziemons, E. (15 January 2018). De l'intérêt de la spectroscopie Raman pour l'analyse pharmaceutique. Paper presented at Conférence Universitaire de Suisse Occidentale, Genève, Switzerland.

Cailletaud, J., De Bleye, C., Dumont, E., Sacre, P.-Y., Netchacovitch, L., Gut, Y., Boiret, M., Ginot, Y.-M., Hubert, P., & Ziemons, E. (05 January 2018). Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field. Journal of Pharmaceutical and Biomedical Analysis, 147, 458-472. doi:10.1016/j.jpba.2017.06.056
Peer Reviewed verified by ORBi

De Bleye, C., Dumont, E., Hubert, C., Jambo, H., Lejeune, R., Ziemons, E., & Hubert, P. (2018). Pré-requis aux travaux pratiques de chimie analytique - Deuxième baccalauréat en Sciences pharmaceutiques. (ULiège - Université de Liège, Belgium, CHIM0321-3 Travaux pratiques - Introduction à la chimie analytique).

Dispas, A., Jambo, H., André, S., Tyteca, E., & Hubert, P. (January 2018). Supercritical fluid chromatography: a promising alternative to current bioanalytical techniques. Bioanalysis, 10 (2), 107-124. doi:10.4155/bio-2017-0211
Peer Reviewed verified by ORBi

De Bleye, C., Dumont, E., Hubert, C., Jambo, H., Lejeune, R., Ziemons, E., & Hubert, P. (2018). Travaux Pratiques: Introduction à la Chimie Analytique Pharmaceutique_Présentation.

Bossens, M., Jost, M., Van Pachterbeke, C., De Maertelaer, V., Simon, P., Frankenne, F., Hubert, P., Evrard, B., & Snoeck, R. (2018). Safety and tolerance of cidofovir as a 2% gel for local application in high-grade cervical intraepithelial neoplasia: A phase 1 investigation. International Journal of Clinical Pharmacology and Therapeutics, 56 (3), 134-141. doi:10.5414/CP203126
Peer Reviewed verified by ORBi

De Bleye, C., Dumont, E., Hubert, C., Jambo, H., Lejeune, R., Ziemons, E., & Hubert, P. (2018). Notes des travaux pratiques de chimie analytique - Deuxième baccalauréat en Sciences pharmaceutiques. (ULiège - Université de Liège, Belgium, CHIM0321-3 Travaux pratiques - Introduction à la chimie analytique).

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (2018). Implementation of a generic SFC-MS method for the quality control of potentially counterfeited medicinal cannabis with synthetic cannabinoids. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1092, 332-342. doi:10.1016/j.jchromb.2018.05.049
Peer Reviewed verified by ORBi

Avohou, T. H., Hubert, C., Debrus, B., Lebrun, P., Rudaz, S., Boulanger, B., & Hubert, P. (2018). Statistical methods in Quality by Design approach to Liquid Chromatography method development. In S. Fekete & I. Molnar, Software-Assisted Method Development for Modeling High Performance Liquid Chromatography (pp. 109-150). London, United Kingdom: World Scientific Publishing. doi:10.1142/q0161
Peer reviewed

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (2018). Quality control of medicinal cannabis: implementation of a generic sfc-ms method to address counterfeiting with synthetic cannabinoids. Poster session presented at International Symposium DA-PBA 2018, Leuven, Belgium.

Coic, L., Sacre, P.-Y., Avohou, T. H., Deidda, R., De Bleye, C., Dumont, E., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (2018). Recent developments of Raman spectroscopy for the qualitative analysis of falsified and substandard medicines. European Pharmaceutical Review.

Hubert, P. (30 November 2017). Valider une méthode analytique,… Pourquoi et comment? Paper presented at Chaire Francqui 2017-2018, Bruxelles, Belgium.

Mavungu Landu, D. J., Frederich, M., Hubert, P., Manzambi Kuwekita, J., Reginster, J.-Y., Michel, B., Gretry, L., Mbongo Pasi, C., Mavungu Nsiona, J., Mbinze, J., & Marini Djang'Eing'A, R. (23 November 2017). Consommation des médicaments antipaludiques : Analyse des échantillons et caractéristiques des pharmacies en territoires périurbains de Kinshasa. Paper presented at Premier Congrès sur la Gestion Intégrée du Risque Sanitaire (COGIRS I), Kinshasa, Congo - Kinshasa.

Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (23 November 2017). Intégration de la validation dans le concept AQbD. Paper presented at AFSEP - "La validation dans l'incertitude, l'incertitude dans la validation : comment garder le sourire?", Paris, France.

Hubert, P. (23 November 2017). La spectroscopie vibrationnelle, un outil efficient pour le contrôle de la qualité des médicaments. Paper presented at Chaire Francqui 2017-2018, Bruxelles, Belgium.

Mavungu Landu, D. J., Mbuyi Kaluka Tshibanda, J., Dasnoy, C., Gretry, L., Mikobi Mikobi, C., Kayembe, J. M., Longo Mbenza, B., Marini Djang'Eing'A, R., Hubert, P., Reginster, J.-Y., Michel, B., Manzambi Kuwekita, J., Jansen, O., & Frederich, M. (10 November 2017). Processus d’intégration de la Médecine traditionnelle dans le système national de soins de la République Démocratique du Congo : Cas de trois zones de santé de Kinshasa. Paper presented at Médecines en Afrique, entre tradition et modernité, Liège, Belgium.

Mavungu Landu, D. J., Mikobi Mikobi, C., Beya, R., Pipo Tshiasuma, M., Kayembe, J. M., Gretry, L., Marini Djang'Eing'A, R., Hubert, P., Reginster, J.-Y., Michel, B., Manzambi Kuwekita, J., & Frederich, M. (10 November 2017). Expérience de l’intégration des cours de Médecine traditionnelle dans la Faculté de Médecine de l’Université Notre-Dame du Kasayi à Kananga. Paper presented at Médecines en Afrique, entre tradition et modernité, Liège, Belgium.

Castiglione, V., Sacre, P.-Y., CAVALIER, E., Hubert, P., GADISSEUR, R., & Ziemons, E. (02 November 2017). Raman Chemical Imaging in Kidney Stone Analysis. Poster session presented at American Society of Nephrology Kidney Week 2017 Annual Meeting, New Orleans, United States.

Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2017). NETTOYAGE DES EQUIPEMENTS ET VALIDATION DE NETTOYAGE - 2017.

Marini Djang'Eing'A, R., Kalenda Tshilombo, N., Ciza Hamuli, P., Mavungu Landu, D. J., Sacre, P.-Y., & Hubert, P. (19 October 2017). Les risques toxicologiques liés aux médicaments de qualité inférieure. Paper presented at 6èmes JOURNEES INTERNATIONALES DE TOXICOLOGIE, Liège, Belgium.

Mavungu Landu, D. J., Liégeois, S., Manzambi Kuwekita, J., Mbinze Kindenge, J., Mavungu Nsiona, J., Hubert, P., Michel, B., Reginster, J.-Y., Frederich, M., Marini Djang'Eing'A, R., & Gretry, L. (13 October 2017). The quality of artemether-lumefantrine combination and characteristics of pharmacies in the periurban areas of kinshasa (Kwete Minga, M., Trans.). Tropical Medicine and International Health, 22 (1), 76.
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Batina Agasa, S., Gulbis, B., BOURS, V., Razy, E., Frederich, M., Guillaume, M., Etienne, A.-M., Mbinze Kindenge, J., Kimoni Kicha, ALWORONG’A OPARA ATIM-NEDI, J.-P., BORIVE AMANI, M., KASONGO MALOBA, P., OPESA LOHATA, A., BANSANDJA LONGEMBE, E., MAVINGA TANA, A., & Hubert, P. (06 October 2017). Drepakis : Contribution to the management of Sickle cell disease in the city of Kisangani (D.R. Congo). Paper presented at 5th Annual International Scientific Conference Society for the Advancement of Science in Africa (SASA) and 2nd Rwanda Biotechnology Conference, Kigali, Rwanda.

Hubert, P., Thewissen, D., & Vandeleene, C. (2017). Le référentiel EFQM - La qualité en formation. Paper presented at Lancement de la L-KMS, Kinshasa, Congo - Brazzaville.

Katemo Muhoya, F., Kadima Ntokamunda, J., Njakarinala Ranarivelo, Frederich, M., Hubert, P., & Marini Djang'Eing'A, R. (05 October 2017). Investigation of content of Panda oleosa (Pierre), a plant used in Kisangani areas for its antihyperglycemic activity. Paper presented at 5th Annual International Scientific Conference Society for the Advancement of Science in Africa (SASA) and 2nd Rwanda Biotechnology Conference, Kigali, Rwanda.

Marini Djang'Eing'A, R., Sacre, P.-Y., Ziemons, E., & Hubert, P. (04 October 2017). Poor quality medicines in Africa: how to combat this real scourge. Paper presented at 5th Annual International Scientific Conference Society for the Advancement of Science in Africa (SASA) and 2nd Rwanda Biotechnology Conference, Kigali, Rwanda.

Cailletaud, J., De Bleye, C., Dumont, E., Jambo, H., Sacre, P.-Y., Gut, Y., Bultel, L., Ginot, Y.-M., Hubert, P., & Ziemons, E. (22 September 2017). Towards a covering aerospray method for quantitative analyses of pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI). Paper presented at Recent Developments in Pharmaceutical Analysis - RDPA 2017, Rimini, Italy.

Dumont, E., De Bleye, C., Cailletaud, J., Jambo, H., Sacre, P.-Y., Aylott, J., Hubert, P., & Ziemons, E. (21 September 2017). Towards the development of a dual mode fluorescence/SERS dopamine aptasensor. Poster session presented at Recent Developments in Pharmaceutical Analysis - RDPA 2017, Rimini, Italy.

Avohou, T. H., Cailletaud, J., Clavaud, M., De Bleye, C., Dumont, E., Marini Djang'Eing'A, R., Sacre, P.-Y., Hubert, P., & Ziemons, E. (20 September 2017). Modern spectral analyses fro drug identification and quantification: From PAT to patient protection. Paper presented at Arlenda Day, Bruxelles, Belgium.

Habyalimana, V., Mbinze Kindenge, J., Yemoa Loconon, A., Kadima Ntokamunda, J.-L., Hubert, P., & Marini Djang'Eing'A, R. (19 September 2017). Simple LC Isocratic Methods Development, Validation, and Application in the Analysis of Poor Quality Antimalarial Medicines. American Journal of Analytical Chemistry, 8, 582-603. doi:10.4236/ajac.2017.89042
Peer reviewed

Dumont, E., De Bleye, C., Cailletaud, J., Jambo, H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (13 September 2017). Development of SERS nanosensors for the detection of small bioactive molecules by cellular analysis in complex matrices: Application to dopamine. Paper presented at PhD Day of the EDT Sciences Pharmaceutiques, Spa, Belgium.

Katemo Muhoya, F., Kadima Ntokamunda, J., Njakarinala Ranarivelo, Frederich, M., Hubert, P., & Marini Djang'Eing'A, R. (11 September 2017). Preliminary Phytochemical Content and Antidiabetic Potential Investigations of Panda oleosa (Pierre) Used in Kisangani Areas. American Journal of Analytical Chemistry, 8, 564-581. doi:10.4236/ajac.2017.89041
Peer reviewed

Andri, B., Dispas, A., Klinkenberg, R., Streel, B., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (27 July 2017). Is supercritical fluid chromatography hyphenated to massspectrometry suitable for the quality control of vitamin D3 oilyformulations? Journal of Chromatography. A, 1515, 209-217. doi:10.1016/j.chroma.2017.07.057
Peer Reviewed verified by ORBi

Clavaud, M., Roggo, Y., Degardin, K., Sacre, P.-Y., Hubert, P., & Ziemons, E. (15 July 2017). Global regression model for moisture content determination using near-infrared spectroscopy. European Journal of Pharmaceutics and Biopharmaceutics, 119, 343-352. doi:10.1016/j.ejpb.2017.07.007
Peer Reviewed verified by ORBi

Clavaud, M., Roggo, Y., Allmendinger, A., Martinez, C., Hubert, P., & Ziemons, E. (11 June 2017). Impact of formulation and process parameters on near-infrared spectra: Application for water determination in biopharmaceuticals. Poster session presented at 18th International Conference on Near Infrared Spectroscopy, Copenhagen, Denmark.

Sacre, P.-Y., Netchacovitch, L., Dumont, E., Cailletaud, J., De Bleye, C., Boiret, M., Hubert, P., & Ziemons, E. (2017). Raman Hyperspectral Imaging: An essential tool in the pharmaceutical field. Eprint/Working paper retrieved from https://orbi.uliege.be/2268/211869.

Yemoa, A., Habyalimana, V., Mbinze Kindenge, J., Crickboom, V., Muhigirwa, B., Ngoya, A., Sacre, P.-Y., Gbaguidi, F., Quetin-Leclercq, J., Hubert, P., & Marini Djang'Eing'A, R. (June 2017). Detection of Poor Quality Artemisinin-based Combination Therapy (ACT) Medicines Marketed in Benin Using Simple and Advanced Analytical Techniques. Current Drug Safety, 12, 178-186. doi:10.2174/1574886312666170616092457
Peer Reviewed verified by ORBi

Clavaud, M., Roggo, Y., Dégardin, K., Lema-Martinez, C., Hubert, P., & Ziemons, E. (2017). Online-Restwasserbestimmung. ChemieXtra: die Fachzeitschrift für die Chemie- und Laborbranche.

Dispas, A., Andri, B., Lebrun, P., & Hubert, P. (18 May 2017). La SFC, une réelle alternative pour le contrôle de qualité des médicaments? Paper presented at Journée thématique de l'AFSEP, Paris, France.

Dispas, A., Andri, B., Lebrun, P., Desfontaine, V., Koroni, D., Clarke, A., Guillarme, D., & Hubert, P. (17 May 2017). Implementation of SFC for the quality control of pharmaceuticals. Paper presented at ChromSoc’s spring symposium 2017 : Supercritical and ultra-high performance chromatography, Sandwich, Kent, United Kingdom.

Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (11 May 2017). Cycle de vie des méthodes, vers une maîtrise intégrée des performances quantitatives. Paper presented at AFSEP - Comment garantir un résultat quantitatif ?, Lyon, France.

Netchacovitch, L., Thiry, J., De Bleye, C., Dumont, E., Cailletaud, J., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (26 April 2017). Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process. Talanta, 171, 45-52. doi:10.1016/j.talanta.2017.04.060
Peer Reviewed verified by ORBi

Mbinze Kindenge, J., Diallo, T., Yemoa, L., Habyalimana, V., Waffo Tchounga, C., Hubert, P., & Marini Djang'Eing'A, R. (April 2017). Etude comparative des profils de dissolution in vitro de quinine sulfate générique et princeps en utilisant la Chromatographie Liquide Haute Performance. Médecine d'Afrique Noire, 64, 135 - 144.
Peer reviewed

Andri, B., Dispas, A., Hubert, P., Al Bakain, R., Sassiat, P., Thiébaut, D., & Vial, J. (30 March 2017). Comment prédire la rétention en chromatographie en phase supercritique à partir des conditions chromatographiques et des descripteurs moléculaires adaptés. Paper presented at SEP 2017, Paris, France.

Marini Djang'Eing'A, R., Ziemons, E., Sacre, P.-Y., & Hubert, P. (2017). Le fléau des faux médicaments. Paper presented at Médicaments ou poisons, Liège, Belgium.

Dispas, A., Desfontaine, V., Andri, B., Lebrun, P., Kotoni, D., Clarke, A., Guillarme, D., & Hubert, P. (30 March 2017). La chromatographie en phase supercritique : une alternative aux méthodes de référence de la Pharmacopée Européenne ? Paper presented at 12e congrès francophone de l’AFSep sur les sciences séparatives et les couplages, Paris, France.

Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Hubert, P., & Ziemons, E. (2017). Raman Hyperspectral Imaging: An essential tool in the pharmaceutical field. Paper presented at Live Webinar, Paris, France.

Andri, B., Dispas, A., Hubert, P., Al Bakain, R., Sassiat, P., Thiébaut, D., & Vial, J. (28 March 2017). Comment prédire la rétention en chromatographie en phase supercritique à partir des conditions chromatographiques et des descripteurs moléculaires adaptés. Poster session presented at SEP 2017, Paris, France.

Andri, B., Dispas, A., Klinkenberg, R., Streel, B., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (28 March 2017). Validation des performances quantitatives d'une méthode SFC-MS pour le contrôle de qualité d'un médicament : le cas de la vitamine D3. Poster session presented at SEP 2017, Paris, France.

Hubert, C., Houari, S., Lebrun, P., Rozet, E., & Hubert, P. (28 March 2017). Validation de l'espace opérationnel : de l'optimisation à la validation en une seule étape. Poster session presented at 12ème Congrès de l'Association Francophone des Sciences Séparatives, Paris, France.

Kalenda Tshilombo, N., Ciza Hamuli, P., Mavungu Landu, D. J., Mwamba, P., Waffo Tchounga, C., Tidiane, D., Mbinze, J., Hubert, P., & Marini Djang'Eing'A, R. (March 2017). INVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA SURVEILLANCE DU MARCHE OFFICIEL ET PERIPHERIQUE DE QUELQUES VILLES DE LA R.D. CONGO. Poster session presented at 12ème Congrès Francophone sur les sciences séparatives et les couplages de AFSEP, Paris, France.

Yemoa, L., Habyalimana, V., Mbinze Kindenge, J., Sacre, P.-Y., Dissou Affolabi, Bigot, A., Atindehou, E., Hubert, P., & Marini Djang'Eing'A, R. (25 February 2017). Apports des méthodes chromatographiques génériques dans la lutte contre la lutte contre la falsification/ contrefaçon des médicaments utilisés dans le traitement des trois maladies prioritaires que sont: la tuberculose, le paludisme et le VIH/SIDA. Paper presented at Colloque Scientifique International de l’Ecole Doctorale de la Santé, Ouagadougou, Burkina Faso.

Habyalimana, V., Mbinze Kindenge, J., Yemoa, L., Waffo Tchounga, C., Diallo, T., Kalenda Tshilombo, N., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (February 2017). Application of design space optimization strategy to the developmentof LC methods for simultaneous analysis of 18 antiretroviral medicinesand 4 major excipients used in various pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis, 139, 8-21. doi:10.1016/j.jpba.2017.02.040
Peer Reviewed verified by ORBi

Dispas, A., Desfontaine, V., Andri, B., Lebrun, P., Kotoni, D., Clarke, A., Guillarme, D., & Hubert, P. (February 2017). Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 134, 170-180. doi:10.1016/j.jpba.2016.11.039
Peer Reviewed verified by ORBi

Andri, B., Al Bakain, R., Dispas, A., Marini Djang'Eing'A, R., Hubert, P., Sassiat, P., Thiébaut, D., & Vial, J. (01 February 2017). Use of Partial Least Squares regression to predict the retention of drugs in gradient mode supercritical fluid chromatography. Paper presented at Chimiométrie XVIII - 2017, Paris, France.

Netchacovitch, L., Dumont, E., Cailletaud, J., Thiry, J., De Bleye, C., Sacre, P.-Y., Boiret, M., Evrard, B., Hubert, P., & Ziemons, E. (2017). Development of an analytical method for crystalline content determination in amorphous solid dispersions produced by Hot-Melt Extrusion using transmission Raman spectroscopy: A feasibility study. International Journal of Pharmaceutics, 530 (1-2), 249-255. doi:10.1016/j.ijpharm.2017.07.052
Peer Reviewed verified by ORBi

Andri, B., Dispas, A., Marini Djang'Eing'A, R., Hubert, P., Sassiat, P., Al Bakain, R., Thiebaut, D., & Vial, J. (2017). Combination of Partial Least Squares regression and Design of Experiments to model the retention of pharmaceuticals in Supercritical Fluid Chromatography. Journal of Chromatography. A. doi:10.1016/j.chroma.2017.02.030
Peer Reviewed verified by ORBi

Andri, B., Lebrun, P., Dispas, A., Klinkenberg, R., Streel, B., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (2017). Optimization and validation of a fast Supercritical Fluid Chromatography method for the quantitative determination of vitamin D3 and its related impurities. Journal of Chromatography. A. doi:10.1016/j.chroma.2017.01.090
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Masereel, B., Verpoorten, D., & Hubert, P. (2017). Création d’un Centre d’Excellence en Assurance et Contrôle de Qualité des Médicaments et Produits de Santé. (Rapport N°1 (juillet - décembre 2016)). Liège, Belgium: ULg - Université de Liège.

Dispas, A., Lebrun, P., & Hubert, P. (2017). Chapter 11 - Validation of Supercritical Fluid Chromatography Methods. In Poole, Colin (Ed.), Supercritical Fluid Chromatography - Handbook in Separation Science. Elsevier. doi:10.1016/B978-0-12-809207-1.00011-2
Peer reviewed

Thiry, J., Lebrun, P., Vinassa, C., Adam, M., Netchacovitch, L., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (30 December 2016). Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination. International Journal of Pharmaceutics, 515 (1-2), 114-124. doi:10.1016/j.ijpharm.2016.10.003
Peer Reviewed verified by ORBi

Mavungu Landu, D. J., Liégeois, S., Manzambi Kuwekita, J., Mbinze Kindenge, J., Hubert, P., Michel, B., Reginster, J.-Y., Frederich, M., & Marini Djang'Eing'A, R. (14 December 2016). Qualité des médicaments antipaludéens et caractéristiques des pharmacies des territoires périurbains de Kinshasa. Poster session presented at CONGRES INTERNATIONAL DE LA PATHOLOGIE INFECTIEUSE ET PARASITAIRE, Kinshasa, Congo - Kinshasa.

Marini Djang'Eing'A, R., Widart, J., & Hubert, P. (2016). L’Assurance Qualité dans un laboratoire.

Hubert, P. (01 December 2016). ASSURANCE QUALITE et RECHERCHE … Paper presented at BioLiège, Liège, Belgium.

Dumont, E., De Bleye, C., Cailletaud, J., Sacre, P.-Y., Netchacovitch, L., Van Lerberghe, P.-B., Rogister, B., Hubert, P., & Ziemons, E. (16 November 2016). Development of a quantitative surface-enhanced Raman scattering method for the analysis of dopamine in cell culture media. Poster session presented at The Bioforum 2016 of BioLiège, Liège, Belgium.

Habyalimana, V., Mbinze Kindenge, J., Yemoa, L., Waffo Tchounga, C., Diallo, T., Kalenda Tshilombo, N., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (18 October 2016). APPLICATION OF DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS FOR SIMULTANEOUS ANALYSIS OF 18 ANTIRETROVIRAL MEDICINES AND 4 MAJOR EXCIPIENTS USED IN VARIOUS PHARMACEUTICAL FORMULATIONS. Paper presented at 19th Forum of Pharmaceutical Sciences / BELGIAN SOCIETY OF PHARMACEUTICAL SCIENCES, Brussels, Belgium.

Kalenda Tshilombo, N., Waffo Tchounga, C., Diallo, T., Mbinze Kindenge, J., Dibungi T. Kalenda, P., Hubert, P., & Marini Djang'Eing'A, R. (18 October 2016). QUALITY EVALUATION OF AMOXICILLIN AND COMBINATION OF AMOXICILLIN – POTASSIUM CLAVULANATE AS PART OF INVESTIGATION OF THE OFFICIAL AND PERIPHERAL DRUG MARKET IN KINSHASA, LUMBUBASHI AND KOLWEZI - DRC. Paper presented at 19th Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Netchacovitch, L., Thiry, J., De Bleye, C., Dumont, E., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (17 October 2016). Determination of the analytical performances of an in-line Raman spectroscopic method monitoring a hot-melt extrusion process. Paper presented at 19th Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Marini Djang'Eing'A, R., & Hubert, P. (2016). Stages internationaux en assurance et contrôle qualité des médicaments et produits de santé. (Rapport 2016 (15 avril - 15 octobre)). Liège, Belgium: ULg - Université de Liège.

Dispas, A., Lebrun, P., Ziemons, E., & Hubert, P. (07 October 2016). SFC: A green alternative for quantitative analysis in the pharmaceutical field? Paper presented at SFC 2016, Vienna, Austria.

Andri, B., Lebrun, P., Dispas, A., Klinkenberg, R., Streel, B., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (October 2016). A fully validated UHPSFC method for the quality control of vitamin D3 as an alternative to pharmacopeias NPLC methods. Poster session presented at 10th International Conference on Packed-column SFC - SFC2016, Vienna, Austria.

Clavaud, M., Roggo, Y., Dégardin, K., Sacre, P.-Y., Hubert, P., & Ziemons, E. (13 September 2016). Moisture content determination in an antibody-drug conjugate freeze-dried medicine by near-infrared spectroscopy: a case study for release testing. Journal of Pharmaceutical and Biomedical Analysis, 131, 380-390. doi:10.1016/j.jpba.2016.09.014
Peer Reviewed verified by ORBi

Andri, B., Dispas, A., Hubert, P., Al Bakain, R., Sassiat, P., Thiébaut, D., & Vial, J. (30 August 2016). A chemometric approach to model the retention behaviour in Supercritical Fluid Chromatography. Paper presented at International Symposium on Chromatography - ISC 2016, Cork, Ireland.

Dispas, A., Lebrun, P., Sacre, P.-Y., & Hubert, P. (29 August 2016). Preliminary study of SFC critical method parameters for the determination of pharmaceutical compounds. Paper presented at International Symposium on Chromatography, Cork, Ireland.

Andri, B., Dispas, A., Hubert, P., Al Bakain, R., Sassiat, P., Thiébaut, D., & Vial, J. (August 2016). Feasibility of the modelling of the retention behaviour in Supercritical Fluid Chromatography with pure in silico descriptors. Poster session presented at International Symposium on Chromatography - ISC 2016, Cork, Ireland.

Andri, B., Lebrun, P., Dispas, A., klinkenberg, R., Streel, B., Marini Djang'Eing'A, R., & Hubert, P. (August 2016). Quality control of vitamin D3 by means of a fully validated UHPSFC method. Poster session presented at International Symposium on Chromatography - ISC 2016, Cork, Ireland.

De Bleye, C., Dumont, E., Dispas, A., Hubert, C., Sacre, P.-Y., Netchacovitch, L., De Muyt, B., Kevers, C., Dommes, J., Hubert, P., & Ziemons, E. (August 2016). Monitoring of anatabine release by methyl jasmonate elicited BY-2 cells using surface-enhanced Raman scattering. Talanta, 160, 754-760. doi:10.1016/j.talanta.2016.08.027
Peer Reviewed verified by ORBi

Netchacovitch, L., Thiry, J., De Bleye, C., Dumont, E., Dispas, A., Hubert, C., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (July 2016). A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process. Talanta, 154, 392-399. doi:10.1016/j.talanta.2016.03.080
Peer Reviewed verified by ORBi

Clavaud, M., Roggo, Y., Degardin, K., Hubert, P., & Ziemons, E. (06 June 2016). MOISTURE CONTENT DETERMINATION OF FREEZE-DRIED PRODUCTS BY NEAR-INFRARED SPECTROSCOPY: A CASE STUDY FOR UNIVERSAL REGRESSION MODEL. Poster session presented at XVI Chemometrics in Analytical Chemistry, Barcelona, Spain.

Dispas, A., Lebrun, P., Sacre, P.-Y., & Hubert, P. (05 June 2016). Screening study of SFC critical method parameters for the determination of pharmaceutical compounds. Journal of Pharmaceutical and Biomedical Analysis, 125, 339-354. doi:10.1016/j.jpba.2016.04.005
Peer Reviewed verified by ORBi

Sacre, P.-Y., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (Other coll.). (2016). Médicaments usage de faux. Moustique.

De Bleye, C., Dumont, E., Dispas, A., Hubert, C., Sacre, P.-Y., Netchacovitch, L., De Muyt, B., Kevers, C., Dommes, J., Hubert, P., & Ziemons, E. (19 May 2016). Use of SERS to monitor the anatabine release in the culture medium by methyl jasmonate elicited BY-2 cells. Poster session presented at Raman Fest 2016, Berlin, Germany.

Hubert, C., Lebrun, P., Rozet, E., & Hubert, P. (10 May 2016). Implementing principles of Quality by Design (QbD) in validation context. Paper presented at Eurachem International Workshop - Method Validation in Analytical Science - Current Practices and Future Challenges, Ghent, Belgium.

Andri, B., Lebrun, P., Dispas, A., Klinkenberg, R., Streel, B., Marini Djang'Eing'A, R., & Hubert, P. (May 2016). Optimization and validation of an UHPSFC method for the quality control of vitamin D3 raw material. Poster session presented at Eurachem Workshop 2016 - Method Validation - Current Practices and Future Challenges, Ghent, Belgium.

Dumont, E., De Bleye, C., Sacre, P.-Y., Netchacovitch, L., Hubert, P., & Ziemons, E. (15 April 2016). From Near-Infrared and Raman to Surface-Enhanced Raman Spectroscopy: Progress, Limitations, Perspectives in Bioanalysis. Bioanalysis, 8 (10), 1077-1103. doi:10.4155/bio-2015-0030
Peer Reviewed verified by ORBi

Widart, J., Beauvois, V., Dumont, F., LASRI, S., LAMBERT, V., PIRSON, L., & Hubert, P. (2016). Réseau Qualité des Laboratoire de l'ULg - Rapport d'activité Février 2016.

Marini Djang'Eing'A, R., & Hubert, P. (2016). Contribution à l'amélioration et au développement de la qualité des médicaments traditionnels et modernes en République Démocratique du Congo. (Rapport Final - Projet Interuniversitaire Ciblé (PIC)). Liège, Belgium: ULg - Université de Liège.

Andri, B., Dispas, A., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (2016). First-International In-SCrit - Rapport d'activité 4. (4).

Andri, B., Dispas, A., Hubert, P., Sassiat, P., Thiébaut, D., & Vial, J. (21 January 2016). Modélisation du comportement chromatographique en SFC. Paper presented at Journée thématique du Club IDF de l'AFSEP, Paris, France.

Andri, B., Dispas, A., Marini Djang'Eing'A, R., & Hubert, P. (January 2016). Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods. American Journal of Analytical Chemistry, 7, 75-91. doi:10.4236/ajac.2016.71008
Peer reviewed

Baldacci-Cresp, F., Sacre, P.-Y., Twyffels, L., Mol, A., Vermeersch, M., Ziemons, E., Hubert, P., Pérez-Morga, D., El Jarizi, M., de Almeida-Engler, J., & Baucher, M. (2016). Poplar-root-knot nematode interaction: a model for perennial woody species. Molecular Plant-Microbe Interactions, 29 (7), 560-572. doi:10.1094/MPMI-01-16-0015-R
Peer Reviewed verified by ORBi

Habyalimana, V., Mbinze Kindenge, J., Kalenda Tshilombo, N., Dispas, A., Yemoa Loconon, A., Sacre, P.-Y., Widart, J., De Tullio, P., Counerotte, S., Kadima Ntokamunda, J.-L., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (02 December 2015). Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines. American Journal of Analytical Chemistry, 6, 977-994. doi:10.4236/ajac.2015.613093
Peer reviewed

Thiry, J., Lebrun, P., Netchacovitch, L., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (23 November 2015). Production of Itraconazole/Soluplus® Extrudates: Optimization of Both Formulation and Hot-Melt Extrusion Process Through a Single Design of Experiment. Paper presented at Biopharmacy Day 2015, Leuven, Belgium.

Chavez, P.-F., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Mantanus, J., Motte, H., Schubert, M., Hubert, P., & Ziemons, E. (01 November 2015). Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool. Talanta, 144, 1352–1359. doi:10.1016/j.talanta.2015.08.018
Peer Reviewed verified by ORBi

Dumont, E., De Bleye, C., Sacre, P.-Y., Netchacovitch, L., Hubert, P., & Ziemons, E. (29 October 2015). Développement de nanosenseurs SERS pour la détection de molécules actives dans des matrices biologiques. Paper presented at Séminaire du CIRM : Présentation des projets des nouveaux chercheurs du centre, Liège, Belgium.

Thiry, J., Lebrun, P., Netchacovitch, L., Pestieau, A., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (October 2015). Production of Itraconazole/Soluplus® Extrudates: Optimization of Both Formulation and Hot-Melt Extrusion Process Through a Single Design of Experiment. Poster session presented at AAPS Orlando 2015.

Marini Djang'Eing'A, R., & Hubert, P. (24 September 2015). VALIDATION RELEVANCE OF ANALYTICAL METHODS IN BIOTECHNOLOGY. Paper presented at Applied Biotechnology in Africa, Butare et Kigali, Rwanda.

Andri, B., Dispas, A., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (2015). First-International In-SCrit - Rapport d'activité 3. (3).

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (September 2015). Vibrational spectroscopy and microspectroscopy analyzing qualitatively and quantitatively pharmaceutical hot melt extrudates. Journal of Pharmaceutical and Biomedical Analysis, 113, 21-33. doi:10.1016/j.jpba.2015.01.051
Peer Reviewed verified by ORBi

De Bleye, C., Dumont, E., Hubert, C., Sacre, P.-Y., Netchacovitch, L., Chavez, P.-F., Hubert, P., & Ziemons, E. (August 2015). A simple approach for ultrasensitive detection of bisphenols by multiplexed surface-enhanced Raman scattering. Analytica Chimica Acta, 888, 118-125. doi:10.1016/j.aca.2015.07.023
Peer Reviewed verified by ORBi

De Bleye, C., Dumont, E., Netchacovitch, L., Chavez, P.-F., Sacre, P.-Y., Hubert, P., & Ziemons, E. (13 July 2015). Development of a simple approach for ultrasensitive detection of bisphenols by multiplexed surface enhanced Raman scattering. Poster session presented at 8th International Conference on Advanced Vibrational Spectroscopy - ICAVS, Vienna, Austria.

Mbinze Kidenge, J.* , Sacre, P.-Y.* , Yemoa, A., Mavar Tayey Mbay, J., Habyalimana, V., Kalenda, N., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (10 July 2015). Development, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops. Journal of Pharmaceutical and Biomedical Analysis, 111, 21-27. doi:10.1016/j.jpba.2015.02.049
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Andri, B., Dispas, A., Hubert, P., Sassiat, P., Thiébaut, D., & Vial, J. (23 June 2015). Investigation and modelling of the retention mechanisms in Supercritical Fluid Chromatography with the help of chemometric tools. Paper presented at HPLC 2015 - 42nd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Geneva, Switzerland.

Chavez, P.-F., Lebrun, P., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Cuypers, S., Mantanus, J., Motte, H., Schubert, M., Evrard, B., Hubert, P., & Ziemons, E. (30 May 2015). Optimization of a Pharmaceutical Tablet Formulation based on a Design Space Approach and using Vibrational Spectroscopy as PAT Tool. International Journal of Pharmaceutics, 486 (1-2), 13-20. doi:10.1016/j.ijpharm.2015.03.025
Peer Reviewed verified by ORBi

Habyalimana, V., Dispas, A., Sacre, P.-Y., Widart, J., De Tullio, P., Counerotte, S., Kadima, N. J., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (28 May 2015). USE OF SIMPLE AND COMPLEX ANALYTICAL TOOLS TO DETECT POOR QUALITY MEDICINES: CASE OF RWANDA. Paper presented at 18th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Kalenda Tshilombo, N., Mbinze Kindenge, J., Kalenda, T. D., Mavar, T. M. J., Hubert, P., & Marini Djang'Eing'A, R. (28 May 2015). QUALITY EVALUATION OF PARACETAMOL AND AMOXICILLINE AS PART OF INVESTIGATION OF THE OFFICIAL AND PERIPHERAL DRUG MARKET IN KINSHASA-DRC. Paper presented at 18th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (21 May 2015). Analysis of film casting by Raman confocal microscopy: An innovative approach in the framework of drug content and API solid-state determination. Paper presented at Forum des jeunes chercheurs, Namur, Belgium.

Ziemons, E., Hubert, C., Marini Djang'Eing'A, R., Rozet, E., Lebrun, P., Boulanger, B., & Hubert, P. (12 May 2015). Validation des méthodes analytiques: Approche basée sur l'erreur totale. Paper presented at Chimie Analytique et chimie des eaux, Mons, Belgium.

Aerts, J., Giacomelli, F., Hubert, P., Ianniello, J., & Marini Djang'Eing'A, R. (09 May 2015). RADIOPHARMACY GMP QC HPLC VALIDATION. Paper presented at 17 th symposium the Belgian Society of Nuclear Medicine, Maastricht, Netherlands.

Ziemons, E., Chavez, P.-F., Netchacovitch, L., De Bleye, C., Sacre, P.-Y., & Hubert, P. (29 April 2015). Intérêt de la spectroscopie vibrationnelle dans le cadre de l'analyse pharmaceutique. Paper presented at Séminaire de l'école doctorale thématique en Sciences Pharmaceutiques, Bruxelles, Belgium.

Sacre, P.-Y., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2015). Médicaments: Faux et usage de faux. Athena, (310), p. 19-22.

Sacre, P.-Y., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (April 2015). Médicaments: Faux et usage de faux. Tempo Médical, 377, p. 33-36.

Andri, B., Dispas, A., Hubert, P., Sassiat, P., Thiébaut, D., & Vial, J. (31 March 2015). Application d'outils chimiométriques pour l'étude et la modélisation du comportement de composés en chromatographie en phase supercritique. Poster session presented at SEP2015 - 11ème congrès de l'Association Française des Sciences Séparatives (AFSEP), Paris, France.

Marini Djang'Eing'A, R., Mbinze, K., Sacre, P.-Y., Ziemons, E., & Hubert, P. (2015). Falsification des médicaments (Falsification des médicaments et conséquences pour la santé publique : cas de l’Afrique subsaharienne ). (ULiège - Université de Liège).

Ziemons, E., Sacre, P.-Y., Marini Djang'Eing'A, R., & Hubert, P. (2015). Falsification des médicaments: Est-il possible d'améliorer la puissance des outils de détection ? Paper presented at Liège Créative, Liège, Belgium.

DUBOIS, N., HALLET, C., SEIDEL, L., Demaret, I., LUPPENS, D., ANSSEAU, M., Rozet, E., Albert, A., Hubert, P., & Charlier, C. (2015). Estimation of the Time Interval between the Administration of Heroin and the Sampling of Blood in Chronic Inhalers. Journal of Analytical Toxicology. doi:10.1093/jat/bkv001
Peer Reviewed verified by ORBi

Beauvois, V., Dumont, F., Hubert, P., & Widart, J. (2015). Réseau Qualité des Laboratoires de l'ULg - Rapport d'activité Février 2015.

Marini Djang'Eing'A, R., Vermaercke, P., & Hubert, P. (2015). Introduction à l’incertitude de mesure - Partim 1. (Introduction à l’incertitude de mesure - Partim 1).

Marini Djang'Eing'A, R., Vermaercke, P., & Hubert, P. (2015). Introduction à l’incertitude de mesure - Partim 2. (Introduction à l’incertitude de mesure - Partim 2).

Andri, B., Dispas, A., Ziemons, E., & Hubert, P. (2015). First International In-Scrit - rapport d'activités 2 ( 08/2014 - 01/2015). (2).

ELKARBANE, M., AMOOD AL-KAMARANY, M., BOUCHAFRA, H., AZOUGAGH, M., CHERRAH, Y., Hubert, P., VANDER HEYDEN, Y., & BOUKLOUZE, A. (February 2015). Total Error-Based Validation Including the Experimental Design-Based Robustness Evaluation of a Stability-Indicating Method for the Simultaneous Quantification of Hydrochlorothiazide and Valsartan in Tablet Formulations. Acta Chromatographica, 27 (2), 1-20. doi:10.1556/AChrom.27.2015.2.1
Peer Reviewed verified by ORBi

Mbinze Kindenge, J., Hubert, P., & Marini Djang'Eing'A, R. (27 January 2015). APPUI ANALYTIQUE A LA LUTTE CONTRE LES MEDICAMENTS DE QUALITE INFERIEURE. Paper presented at Les Rencontres du Développement, Liège, Belgium.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., Hubert, C., & Hubert, P. (22 January 2015). Design Space for Analytical Methods: Why ? What ? How ? Paper presented at AFSEP - Innovation en développements de méthodes, Lyon, France.

Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Hubert, P., & Ziemons, E. (20 January 2015). Distributional homogeneity index (DHI), a valuable tool during pharmaceutical development. Paper presented at Chimiométrie XVI, Genève, Switzerland.

Mbinze, K., Nsangu Mpasi, J., Maghe, E., Kobo, S., Mwanda, R., Mulumba, G., Bolavie Bolande, J., Bayebila Menanzambi, T., Borive Amani, M., Hubert, P., & Marini Djang'Eing'A, R. (19 January 2015). Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines. American Journal of Analytical Chemistry, 6, 106-117. doi:10.4236/ajac.2015.62010
Peer reviewed

Mbinze Kindenge, J., Yemoa, A., Lebrun, P., Sacre, P.-Y., Habyalimana, V., Kalenda Tshilombo, N., Bigot, A., Atindehou, E., Hubert, P., & Marini Djang'Eing'A, R. (19 January 2015). Fighting Poor Quality Medicines: Develop-ment, Transfer and Validation of Generic HPLC Methods for Analyzing two WHO Recommended Antimalarial Tablets. American Journal of Analytical Chemistry, 6, 127-144. doi:10.4236/ajac.2015.62012
Peer reviewed

Clavaud, M., Roggo, Y., Hubert, P., & Ziemons, E. (January 2015). Moisture content determination of a new antibody-drug conjugate lyophilize by Near-Infrared Spectroscopy (NIRS) for release and stability analysis. Poster session presented at Chimiométrie XVI, Genève, Switzerland.

Andri, B., Dispas, A., Hubert, P., Sassiat, P., Thiébaut, D., & Vial, J. (2015). Feasibility of retention prediction using chemometric tools in supercritical fluid chromatography. Paper presented at The 18th FORUM OF PHARMACEUTICAL SCIENCES, Blankenberge, Belgium.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Sacre, P.-Y., Krier, F., Evrard, B., Hubert, P., & Ziemons, E. (January 2015). Confocal Raman microscopy to support the development of an extrusion process: a quantitative approach based on film casting. Poster session presented at CHimiometrie XVI, Genève, Switzerland.

Thiry, J., Netchacovitch, L., Krier, F., Ziemons, E., Hubert, P., & Evrard, B. (2015). Determination of the Crystal Content within an Itraconazole-based extrudate : Comparison between Differential Scanning Calorimetry and Raman techniques. Poster session presented at TA Instruments' BeNeLux Users Meeting & Symposium 2015.

Sacre, P.-Y., Netchacovitch, L., De Bleye, C., Chavez, P.-F., Servais, C., Klinkenberg, R., Streel, B., Hubert, P., & Ziemons, E. (2015). Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study. International Journal of Pharmaceutics, 484, 85-94. doi:10.1016/j.ijpharm.2015.02.052
Peer Reviewed verified by ORBi

OZKAN, S., KAUFFMANN, J.-M., Rozet, E., & Hubert, P. (2015). Electroanalytical Method Validation in Pharmaceutical Analysis and Their Applications. In S. A. Ozkan, J.-M. Kauffmann, & P. Zuman, Electroanalysis in Biomedical and Pharmaceutical Sciences : Voltammetry, Amperometry, Biosensors, Applications (1 edition, pp. 235-265). Berlin Heidelberg, Germany: Springer-Verlag. doi:10.1007/978-3-662-47138-8
Peer reviewed

Marini Djang'Eing'A, R., Kalenda Tshilombo, N., Habyalimana, V., Dispas, A., Liégeois, S., Yemoa Loconon, & Hubert, P. (2015). Falsification des médicaments en milieu périurbain : triste réalité. In J. Bogaert & J.-M. Halleux, Territoires périurbains. Développement, enjeux et prespectives dans les pays du Sud (pp. 193 - 202). Gembloux, Belgium: Presses agronomiques de Gembloux.
Peer reviewed

Dispas, A., Mbinze Kindenge, J., Lecomte, F., Marini Djang'Eing'A, R., & Hubert, P. (2015). Qualification de l'équipement. (ULiège - Université de Liège, PHIN2023-1 Analyse des médicaments - Méthodes d'analyse pharmaceutique et biopharmaceutique partim a : validation et qualification de l'appareillage).

Hubert, C., Houari, S., Rozet, E., Lebrun, P., & Hubert, P. (2015). Towards a full integration of optimization and validation phases: An Analytical-Quality-by-Design approach. Journal of Chromatography. A. doi:10.1016/j.chroma.2015.03.059
Peer Reviewed verified by ORBi

Andri, B., Dispas, A., Hubert, P., Sassiat, P., Thiébaut, D., & Vial, J. (January 2015). Application of chemometric tools for the investigation of chromatographic behaviour in Supercritical Fluid Chromatography. Poster session presented at CHimiométrie XVI, Genève, Switzerland.

Sakira, A. K., Somé, I. T., Ziemons, E., Dejaegher, B., Mertens, D., Hubert, P., & Kauffmann, J.-M. (2015). Determination of arsenic (III) at a nano gold modified solid carbon paste electrode. Electroanalysis, 27, 309-316. doi:10.1002/elan.201400485
Peer Reviewed verified by ORBi

Ziemons, E., Chavez, P.-F., Netchacovitch, L., De Bleye, C., Sacre, P.-Y., & Hubert, P. (13 November 2014). Intérêt de la spectroscopie vibrationnelle dans le cadre du PAT. Paper presented at Séminaire du CIRM, Liège, Belgium.

Chavez, P.-F., Lebrun, P., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Mantanus, J., Motte, H., Schubert, M., Hubert, P., & Ziemons, E. (13 November 2014). Optimization of a Pharmaceutical Tablet Formulation using a Design Space Approach and Vibrational Spectroscopy as PAT Tool. Paper presented at Séminaire du CIRM, Liège, Belgium.

Marini Djang'Eing'A, R., & Hubert, P. (12 November 2014). Falsification des médicaments en Afrique : état de la question. Paper presented at Conférence - Débat, Bruxelles, Belgium.

Netchacovitch, L., De Bleye, C., Chavez, P.-F., Sacre, P.-Y., Hubert, P., & Ziemons, E. (November 2014). Raman hyperspectral imaging: a single tool to characterise pharmaceutical products. European Pharmaceutical Review, 19 (5), 8-11.

Chavez, P.-F., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Mantanus, J., Motte, H., Schubert, M., Hubert, P., & Ziemons, E. (November 2014). Determination of API Content in Proportional Pharmaceutical Tablet Forms by Near Infrared Spectroscopy. Poster session presented at 2014 AAPS Annual Meeting and Exposition, San Diego, United States - California.

Sacre, P.-Y., De Bleye, C., Chavez, P.-F., Netchacovitch, L., Hubert, P., & Ziemons, E. (October 2014). Data processing of vibrational chemical imaging for pharmaceutical applications. Journal of Pharmaceutical and Biomedical Analysis, 101, 123-140. doi:10.1016/j.jpba.2014.04.012
Peer Reviewed verified by ORBi

Dispas, A., Lebrun, P., Ziemons, E., Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (August 2014). Evaluation of the quantitative performances of Supercritical Fluid Chromatography : from method development to validation. Journal of Chromatography. A, 1353 (Method Validation), 78-88. doi:10.1016/j.chroma.2014.01.046
Peer Reviewed verified by ORBi

Andri, B., Dispas, A., Ziemons, E., & Hubert, P. (2014). Projet First International In-SCrit - rapport d'activités 1 (02/2014 - 08/2014). (1).

Andri, B., Dispas, A., Klinkenberg, R., Streel, B., & Hubert, P. (23 June 2014). Evaluation of SFC interest for the determination of cholecalciferol and its impurities in pharmaceuticals. Poster session presented at Drug Analysis 2014, Liege, Belgium.

De Bleye, C., Dumont, E., Sacre, P.-Y., Chavez, P.-F., Netchacovitch, L., Piel, G., Hubert, P., & Ziemons, E. (23 June 2014). Development of a multiplexed surface-enhanced Raman scattering quantitative approach for bisphenols detection. Paper presented at Drug Analysis 2014, Liège, Belgium.

Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J., & Liégeois, J.-F. (05 June 2014). A PREFERENTIAL FOLDED CONFORMATION OF SOME BIS-(8-ISOPROPYL-ISOQUINOLINIUM) DERIVATIVES EXPLAINS STEREOSELECTIVE REDUCTION BY SODIUM BOROHYDRIDE. Poster session presented at 28èmes Journées Franco-Belges de Pharmacochimie, Metz, France.

Dispas, A., Lebrun, P., & Hubert, P. (June 2014). Quantitative performances of UHPSFC and UHPLC : a comparative study. Paper presented at Drug Analysis 2014, Liège, Belgium.

Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Chavez, P.-F., Klinkenberg, R., Streel, B., Hubert, P., & Ziemons, E. (June 2014). Application of hyperspectral Raman imaging to the analysis of a self-emulsifying drug delivery system (SEDDS). Poster session presented at Drug Analysis 2014.

Netchacovitch, L., Thiry, J., De Bleye, C., Sacre, P.-Y., Chavez, P.-F., Krier, F., Evrard, B., Hubert, P., & Ziemons, E. (June 2014). Confocal Raman microscopy to support the development of an extrusion process by qualitative and quantitative analyses. Poster session presented at Drug Analysis 2014.

Pestieau, A., Krier, F., Thoorens, G., Dupont, A., Chavez, P.-F., Ziemons, E., Hubert, P., & Evrard, B. (June 2014). Towards a real time release approach for manufacturing tablets using NIR spectroscopy. Poster session presented at Drug Analysis 2014, Liège, Belgium.

Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., De Bleye, C., Lebrun, P., Motte, H., Schubert, M., Evrard, B., Hubert, P., & Ziemons, E. (June 2014). Optimization of a Pharmaceutical Tablet Formulation using a Design Space Approach and Vibrational Spectroscopy as PAT Tool. Poster session presented at Drug Analysis 2014, Liège, Belgium.

Habyalimana, V., Kalenda Tshilombo, N., Dispas, A., Andri, B., Loconon Yemoa, A., Kindenge Mbinze, J., Kadima Ntokamunda, J., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (June 2014). MULTI-TRANSFER OF GENERIC ANALYTICAL METHODS TO COMBAT POOR QUALITY ANTIMALARIAL MEDICINES: A LABORATORY BASED APPROACH TO SUPPORT DRUG QA/QC SYSTEMS. Poster session presented at DRUG ANALYSIS 2014: 10th International Symposium on Drug Analysis & 25th International Symposium on Pharmaceutical and Biomedical Analysis.

Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J., & Liégeois, J.-F. (2014). Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride. Journal of Molecular Structure. doi:10.1016/j.molstruc.2014.06.042
Peer Reviewed verified by ORBi

Netchacovitch, L., De Bleye, C., Sacre, P.-Y., Chavez, P.-F., Hubert, P., & Ziemons, E. (15 May 2014). Qualitative and quantitative analyses of a pharmaceutical formulation produced by hot melt extrusion using Raman spectroscopy. Poster session presented at Bioforum 2014, Liège, Belgium.

De Bleye, C., Dumont, E., Sacre, P.-Y., Chavez, P.-F., Netchacovitch, L., Piel, G., Hubert, P., & Ziemons, E. (15 May 2014). Development of an analytical method to detect simultaneously bisphenols using a multiplexed surface-enhanced Raman scattering quantitative approach. Poster session presented at The Bioforum 2014 of BioLiège, Liège, Belgium.

Sacre, P.-Y., Deconinck, E., Marini Djang'Eing'A, R., Ziemons, E., Hubert, P., CHIAP, P., Crommen, J., & De Beer, J. O. (May 2014). Stratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectile. Spectra Analyse, 43, 37.
Peer reviewed

Pestieau, A., Krier, F., Thoorens, G., Dupont, A., Chavez, P.-F., Ziemons, E., Hubert, P., & Evrard, B. (May 2014). Towards a real time release approach for manufacturing tablets using NIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 98, 60-67. doi:10.1016/j.jpba.2014.05.002
Peer Reviewed verified by ORBi

Lamalle, C., Baptiste, E., Marini Djang'Eing'A, R., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (May 2014). Développement de méthodes séparatives pour détecter la contrefaçon de molécules biosynthétiques comme l'insuline et les GHRP. Spectra Analyse, 43, 47-50.
Peer reviewed

Rudaz, S., & Hubert, P. (May 2014). Lutter contre le fléau des médicaments contrefaits. Spectra Analyse, 298, 3.
Peer reviewed

Habyalimana, V., Kalenda Tshilombo, N., Dispas, A., Mbinze Kindenge, J., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (May 2014). Méthodes chromatographiques génériques de criblage pour lutter contre les médicaments de qualité inférieure. Spectra Analyse, 43, 30.
Peer reviewed

Mbinze Kindenge, J., Kalenda Tshilombo, N., Chavez, P.-F., De Bleye, C., Sacre, P.-Y., Mavar Tayey Mbay, J., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (May 2014). La spectroscopie proche infrarouge, une technique non destructive dans la lutte contre la contrefaçon des médicaments. Spectra Analyse, 43, 43.
Peer reviewed

Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Chavez, P.-F., Hubert, P., & Ziemons, E. (08 April 2014). Intérêt de l'imagerie Raman pour l'analyse de préparations pharmaceutiques. Paper presented at CIRM.

Some, I., Guel, B., Hantson, A.-L., Hubert, P., Ziemons, E., Mertens, D., & Kauffmann, J.-M. (19 March 2014). Contribution à l'amélioration de l'accès à une eau potable de qualité pour les populations de la région nord du Burkina Faso. Poster session presented at 7ème Journée de la Coopération, Bruxelles, Belgium.

De Bleye, C.* , Sacre, P.-Y.* , Dumont, E., Netchacovitch, L., Chavez, P.-F., Piel, G., Lebrun, P., Hubert, P., & Ziemons, E. (05 March 2014). Development of a quantitative approach using surface-enhanced Raman chemical imaging: First step for the determination of an impurity in a pharmaceutical model. Journal of Pharmaceutical and Biomedical Analysis, 90, 111-118. doi:10.1016/j.jpba.2013.11.026
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Beauvois, V., Dumont, F., Hubert, P., & Widart, J. (2014). Réseau Qualité des Laboratoires de l'ULg - Rapport d'activité Février 2014.

Marini Djang'Eing'A, R., & Hubert, P. (2014). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport final - DEV-AQM). Liège, Belgium: ULg - Université de Liège.

Hubert, C., Lebrun, P., Houari, S., Ziemons, E., Rozet, E., & Hubert, P. (25 January 2014). Improvement of a stability-indicating method by Quality-by-Design versus Quality-by-Testing: A case of a learning process. Journal of Pharmaceutical and Biomedical Analysis, 88, 401-409. doi:10.1016/j.jpba.2013.09.026
Peer Reviewed verified by ORBi

Memvanga Bondo, P., Mbinze Kindenge, J., Rozet, E., Hubert, P., Préat, V., & Marini Djang'Eing'A, R. (25 January 2014). Development of a liquid chromatographic method for thesimultaneous quantification of curcumin, -arteether,tetrahydrocurcumin and dihydroartemisinin. Application to lipid-based formulations. Journal of Pharmaceutical and Biomedical Analysis, 88, 447-456. doi:10.1016/j.jpba.2013.09.009
Peer Reviewed verified by ORBi

De Bleye, C., Sacre, P.-Y., Dumont, E., Chavez, P.-F., Netchacovitch, L., Piel, G., Rozet, E., Lebrun, P., Hubert, P., & Ziemons, E. (20 January 2014). Quantitative approaches based on Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Raman Chemical Imaging (SER-CI). Paper presented at Forum des jeunes chercheurs, Liège, Belgium.

Dispas, A., Lebrun, P., Andri, B., Rozet, E., & Hubert, P. (January 2014). Robust method optimization strategy – a useful tool for method transfer: the case of SFC. Journal of Pharmaceutical and Biomedical Analysis, 88, 519-524. doi:10.1016/j.jpba.2013.09.030
Peer Reviewed verified by ORBi

Renard, J.-F., Lecomte, F., Hubert, P., de Leval, X., & Pirotte, B. (2014). N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: Cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. European Journal of Medicinal Chemistry, 74, 12-22. doi:10.1016/j.ejmech.2013.12.033
Peer Reviewed verified by ORBi

Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Rozet, E., Klinkenberg, R., Streel, B., Hubert, P., & Ziemons, E. (2014). A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms. Analytica Chimica Acta, 818, 7-14. doi:10.1016/j.aca.2014.02.014
Peer Reviewed verified by ORBi

Houbart, V., Lecomte, F., COBRAIVILLE, G., Crommen, J., Hubert, P., & Fillet, M. (2014). Influence of sample and mobile phase composition on peptide retention behavior and detector response in miniaturized LC-MS. Poster session presented at Hyphenated Techniques in Chromatography and Separation Technology 2014.

Marini Djang'Eing'A, R., Kalenda Tshilombo, N., Habyalimana, V., Dispas, A., Liégeois, S., & Hubert, P. (19 December 2013). FALSIFICATION DES MÉDICAMENTS EN MILIEU PÉRIURBAIN : TRISTE RÉALITÉ. Paper presented at "Territoires périurbains : Développement, enjeux et perspectives dans les Pays du Sud", Gembloux, Belgium.

De Bleye, C., Dumont, E., Rozet, E., Sacre, P.-Y., Chavez, P.-F., Netchacovitch, L., Piel, G., Hubert, P., & Ziemons, E. (15 November 2013). Determination of 4-aminophenol in a pharmaceutical formulation using Surface Enhanced Raman scattering: from development to method validation. Talanta, 116, 899-905. doi:10.1016/j.talanta.2013.07.084
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2013). Validation data treatment. (-, ULiège - Université de Liège, Validation des Méthodes Analytiques). Liège, Belgium: -.

Pestieau, A., Krier, F., Thoorens, G., Dupont, A., Chavez, P.-F., Ziemons, E., Hubert, P., & Evrard, B. (November 2013). Real time release approach in terms of four Pharmacopoeia tests for tablets manufacturing using NIR spectroscopy. Poster session presented at AAPS Annual Meeting and Exposition, San Antonio, United States.

Mbinze Kindenge, J., Dispas, A., Lebrun, P., Mavar Tayey Mbay, J., Habyalimana, V., Kalenda Tshilombo, N., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (November 2013). Application of an innovative design space optimization strategy to thedevelopment of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines. Journal of Pharmaceutical and Biomedical Analysis, 85, 83– 92. doi:10.1016/j.jpba.2013.06.036
Peer Reviewed verified by ORBi

Dias, A. L., Rozet, E., Larondelle, Y., Hubert, P., Rogez, H., & Quetin-Leclercq, J. (2013). Development and validation of a UHPLC−LTQ−Orbitrap MS method for non-anthocyanin flavonoids quantification in Euterpe oleracea juice. Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-013-7325-z
Peer Reviewed verified by ORBi

Memvanga Bondo, P., Mbinze Kindenge, J., Rozet, E., Hubert, P., Préat, V., & Marini Djang'Eing'A, R. (17 October 2013). Development of a liquid chromatographic method for the simultaneous quantification of curcumin, β-arteether, tetrahydrocurcumin and dihydroartemisinin. Application to lipid-based formulations. Paper presented at 17ème Forum des Sciences Pharmaceutiques, Spa, Belgium.

Netchacovitch, L., Sacre, P.-Y., Chavez, P.-F., De Bleye, C., Hubert, P., & Ziemons, E. (17 October 2013). Raman chemical imaging as qualitative and quantitative tool to characterize solid pharmaceutical formulations. Paper presented at 17th Forum of Pharmaceutical Sciences, Spa, Belgium.

De Bleye, C., Sacre, P.-Y., Dumont, E., Chavez, P.-F., Netchacovitch, L., Piel, G., Rozet, E., Lebrun, P., Hubert, P., & Ziemons, E. (17 October 2013). Development of a quantitative approach based on surface-enhanced Raman chemical imaging (SER-CI). Paper presented at Belgian Society of Pharmaceutical Sciences, Spa, Belgium.

Kalenda Tshilombo, N., Mbinze Kindenge, J., Habyalimana, V., Dispas, A., Kalenda Dibungi T, P., Mavar Tayey Mbay, J., Hubert, P., & Marini Djang'Eing'A, R. (17 October 2013). QUALITY CONTROL OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID), ANTIMALARIALS AND ANTIBIOTICS IN THE FRAME OF FIGHTING AGAINST POOR QUALITY MEDICINES. Paper presented at 17ème Forum des Sciences Pharmaceutiques, Spa, Belgium.

Dispas, A., Lebrun, P., & Hubert, P. (October 2013). Robust SFC method optimization using design space strategy. Paper presented at 17e Forum des Sciences Pharmaceutiques, Spa, Belgium.

DUBOIS, N., HALLET, C., SEIDEL, L., Rozet, E., LUPPENS, D., ANSSEAU, M., Hubert, P., Albert, A., & Charlier, C. (October 2013). Estimation du délai entre la consommation d'héroïne et le prélèvement chez des consommateurs chroniques. Poster session presented at 5èmes Journées Internationales de Toxicologie, Liège, Belgium.

Ziemons, E., De Bleye, C., Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., Rozet, E., Lebrun, P., & Hubert, P. (10 September 2013). Vibrational spectroscopy as PAT compliant tools. Paper presented at Chemical Manufacturing and Control (CMC) Seminar, Diepenbeek, Belgium.

Lautié, E., Rozet, E., Hubert, P., Vandelaer, N., Billard, F., zum Felde, T., Grünenberg, W.-J., & Quetin-Leclercq, J. (September 2013). Fast method for the simultaneous quantification of toxic polyphenols applied to the selection of genotypes of yam bean (Pachyrhizus sp.) seeds. Talanta, 117, 94-101. doi:10.1016/j.talanta.2013.08.038
Peer Reviewed verified by ORBi

Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., De Bleye, C., Lebrun, P., Motte, H., Evrard, B., Hubert, P., & Ziemons, E. (September 2013). Application of a Design Space Approach for a Pharmaceutical Tablet Formulation Optimization based on a Mixture Design of Experiments and using Vibrational Spectroscopy as PAT Tool. Poster session presented at EuPAT 6 - Sixth pan-European QbD & PAT Science Conference, Porto, Portugal.

Dispas, A., Ziemons, E., & Hubert, P. (2013). Chimie Analytique - Manuel de Travaux Pratiques. (ULiège - Université de Liège, CHIM0330-3 Chimie Analytique (partim 1)).

Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Rozet, E., Hubert, P., & Ziemons, E. (September 2013). A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms. Paper presented at EuPAT 6 (Sixth pan-European QbD & PAT Science Conference), Porto, Portugal.

Ziemons, E., Moonen, F., & Hubert, P. (23 July 2013). Analyzing spectral data for the selection of a calibration model.

Dispas, A., Mbinze Kindenge, J., Lebrun, P., Kalenda, N., Habyalimana, V., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (July 2013). ANALYTICAL DESIGN SPACE STRATEGY FOR THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT ANTIBIOTIC DRUGS. Paper presented at 24th International Symposium on Pharmaceutical and Biomedical Analysis, Bologne, Italy.

Debrus, B., Lebrun, P., Rozet, E., Schofield, T., Mbinze Kindenge, J., Marini Djang'Eing'A, R., Rudaz, S., Boulanger, B., & Hubert, P. (2013). A New Method for Quality by Design Robust Optimization in Liquid Chromatography. LC-GC Europe.
Peer reviewed

De Bleye, C., Sacre, P.-Y., Chavez, P.-F., Netchacovitch, L., Dumont, E., Rozet, E., Piel, G., Hubert, P., & Ziemons, E. (July 2013). Chemical imaging of small molecules from simple to complex matrices: Quantitative approaches based on Surface Enhanced Raman scattering. Paper presented at Symposium on Pharmaceutical and Biomedical Analysis 2013 (PBA 2013), Bologna, Italy.

Hubert, C., Lebrun, P., Houari, S., Dispas, A., Rozet, E., Ziemons, E., & Hubert, P. (July 2013). Innovative strategy based on the quality by design concept for the development of a LC/MS method. Poster session presented at 24th Symposium on Pharmaceutical and Biomedical Analysis, Bologna, Italy.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (06 June 2013). Innovative Methodology for the Definition of Design Spaces of Chromatographic Methods. Paper presented at 10ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Paris, France.

Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., De Bleye, C., Pestieau, A., Krier, F., Mantanus, J., Motte, H., Schubert, M., Evrard, B., Hubert, P., & Ziemons, E. (June 2013). Optimization of a Pharmaceutical Tablet Formulation: Screening Experiments using Vibrational Spectroscopy as PAT Tool. Poster session presented at 2013 AAPS Annual Meeting and Exposition, San Antonio, United States - Texas.

Dispas, A., Lebrun, P., Rozet, E., Ziemons, E., Vial, J., Thiébaut, D., & Hubert, P. (June 2013). Optimisation robuste de méthodes SFC par une approche de type design space. Paper presented at 10e congrès francophone de l'Afsep sur les sciences séparatives et les couplages, Paris, France.

Hubert, C., Lebrun, P., Houari, S., Dispas, A., Rozet, E., Ziemons, E., & Hubert, P. (June 2013). Innovative strategy based on the quality by design concept for the development of a LC/MS method. Poster session presented at 10ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Paris, France.

Chavez, P.-F., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Motte, H., Hubert, P., & Ziemons, E. (June 2013). Qualitative Approaches to Monitor Pharmaceutical Blending Processes using In-line Near-Infrared Spectroscopy. Poster session presented at 24th Symposium on Pharmaceutical and Biomedical Analysis (PBA2013), Bologna, Italy.

Lamalle, C., Sacre, P.-Y., Marini Djang'Eing'A, R., Servais, A.-C., Hubert, P., Fillet, M., & Crommen, J. (June 2013). ANALYTICAL STRATEGIES FOR THE DETECTION AND CHARACTERIZATION OF COUNTERFEIT MEDICINES. Paper presented at 24th Symposium on Pharmaceutical and Biomedical Analysis (PBA2013) / RDPA 2013, Bologna, Italy.

Rozet, E., Lebrun, P., Boulanger, B., & Hubert, P. (21 May 2013). A BAYESIAN PROBABILITY CRITERION TO ASSESS ANALYTICAL RESULTS RELIABILITY. Paper presented at BAYES 2013, Rotterdam, Netherlands.

Rozet, E., De Tullio, P., Hubert, P., & Govaerts, B. (13 May 2013). MEASURING VARIABILITY SOURCES IN NMR METABOLOMIC STUDIES. Paper presented at First Belgian-Netherlands Joint symposium on Metabolomics, SPA, Belgium.

Dias, A., Rozet, E., Chataigné, G., Margalho, L., Larondelle, Y., Hubert, P., Roger, H., & Quetin-Leclercq, J. (May 2013). NON-ANTHOCYANIN POLYPHENOLS QUANTIFICATION IN EUTERPE OLERACEA FRUITS BY A UHPLC−LTQ-ORBITRAP MS METHOD. Poster session presented at Journées internationales AFERP & STOLON.

Marini Djang'Eing'A, R., Fillet, M., Vancauwenberghe, R., Crommen, J., Frederich, M., & Hubert, P. (24 April 2013). Falsification des médicaments: mythe ou réalité ? Paper presented at Cours-conférences 2013 Sciences Biologiques et Médicales, Namur, Belgium.

De Bleye, C., Dumont, E., Chavez, P.-F., Netchacovitch, L., Piel, G., Rozet, E., Sacre, P.-Y., Hubert, P., & Ziemons, E. (18 April 2013). Development of quantitative approaches based on Surface Enhanced Raman Scattering chemical imaging. Poster session presented at The bioforum 2013 of BioLiège, Liège, Belgium.

Chavez, P.-F., De Bleye, C., Sacre, P.-Y., Rozet, E., Hubert, P., & Ziemons, E. (February 2013). Validation methodologies of near infrared spectroscopy methods in pharmaceutical applications. European Pharmaceutical Review, 18 (1), 3-6.

Rozet, E., Ziemons, E., Marini Djang'Eing'A, R., Boulanger, B., & Hubert, P. (2013). Methodology for the Validation of Analytical Methods involved in Uniformity of Dosage Units tests. Analytica Chimica Acta, 760, 46-52. doi:10.1016/j.aca.2012.11.013
Peer Reviewed verified by ORBi

Rozet, E., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (2013). Usefulness of Information Criteria for the Selection of Calibration Curves. Analytical Chemistry, 85, 6327-6335. doi:10.1021/ac400630k
Peer Reviewed verified by ORBi

DUBOIS, N., HALLET, C., SEIDEL, L., LUPPENS, D., ANSSEAU, M., Hubert, P., Albert, A., & Charlier, C. (2013). Estimation du délai entre la consommation d'héroïne et le prélèvement chez des consommateurs chroniques. Acta Clinica Belgica, 68 (6), 481.

Krier, F., Mantanus, J., Sacre, P.-Y., Chavez, P.-F., Thiry, J., Pestieau, A., Rozet, E., Ziemons, E., Hubert, P., & Evrard, B. (2013). PAT tools for the control of co-extrusion implants manufacturing process. International Journal of Pharmaceutics, 458, 15-24. doi:10.1016/j.ijpharm.2013.09.040
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Debrus, B., Lambert, P., & Hubert, P. (2013). A Bayesian Design Space for analytical methods based on multivariate models and predictions. Journal of Biopharmaceutical Statistics, 23, 1330–1351. doi:10.1080/10543406.2013.834922
Peer Reviewed verified by ORBi

Lahbib, A., Lecomte, F., Ghodbane, S., Hubert, P., Sakly, M., & Abdelmelek, H. (2013). Static Magnetic Field Induced Hypovitaminosis D in Rat. Journal of Veterinary Medical Science, 75 (9), 1181-1185. doi:10.1292/jvms.13-0105
Peer Reviewed verified by ORBi

Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Oprean, R., Badarau, E., Dufour, F., Dossou, K. S. S., Fillet, M., Liégeois, J.-F., Hubert, P., & Rozet, E. (2013). Implementation of a Design Space Approach for Enantiomeric Separations in Polar Organic Solvent Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 74, 273-283. doi:10.1016/j.jpba.2012.10.015
Peer Reviewed verified by ORBi

DUBOIS, N., Demaret, I., ANSSEAU, M., Rozet, E., Hubert, P., & Charlier, C. (2013). Plasma level monitoring of the major metabolites of diacetylmorphine (heroin) by the "chasing the dragon" route in severe heroin addicts. Acta Clinica Belgica, 68 (5), 359-367. doi:10.2143/ACB.3323
Peer Reviewed verified by ORBi

Tiuca, I., Saponar, A., Bodoki, A., Ziemons, E., Bodoki, E., Hubert, P., & Oprean, R. (2013). ATR-IR and Raman spectroscopic study of interaction between major calixarene derivatives and oral anticoagulants. Farmacia, 61 (5), 874-882.
Peer reviewed

Rozet, E., Lebrun, P., Debrus, B., Boulanger, B., & Hubert, P. (2013). Design Spaces for Analytical Methods. TrAC: Trends in Analytical Chemistry, 42, 157-167. doi:10.1016/j.trac.2012.09.007
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2012). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport d'activité de 36 mois, -). Liège, Belgium: ULg.

Sacre, P.-Y., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2012). Intérêt de la microscopie vibrationnelle dans la recherche de nouvelles formulations pharma-ceutiques à haute valeur ajoutée. (Rapport d'activité de 12 mois, -). Liège, Belgium: ULg.

Krier, F., mantanus, J., Ziemons, E., Hubert, P., & Evrard, B. (16 October 2012). Comparison of in-line active content determination of polymeric implant by near infrared spectroscopy and Raman spectroscopy. Poster session presented at Congrés annuel de l'AAPS2012.

Dispas, A., Lebrun, P., Sassiat, P., Thiébaut, D., Vial, J., & Hubert, P. (October 2012). Innovative green supercritical fluid chromatography development for the separation of neurotransmitters using design space strategy. Paper presented at SFC2012, Bruxelles, Belgium.

Ziemons, E., Ceccato, A., & Hubert, P. (2012). Content uniformity determination in silicone-based drug reservoirs by near infrared spectroscopy.

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Kalenda Tshilombo, N., Mavar Tayey Mbay, J., Schofield, T., Boulanger, B., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (12 September 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Journal of Chromatography. A, 1263, 113-124. doi:10.1016/j.chroma.2012.09.038
Peer Reviewed verified by ORBi

Dispas, A., Lebrun, P., Sassiat, P., Ziemons, E., Thiébaut, D., Vial, J., & Hubert, P. (September 2012). Innovative green supercritical fluid chromatography development for the determination of polar compounds. Journal of Chromatography. A, 1256, 253-260. doi:10.1016/j.chroma.2012.07.043
Peer Reviewed verified by ORBi

Chavez, P.-F., Hubert, P., & Ziemons, E. (2012). Pharmaceutical tablet: Improvement on API content uniformity. ULg - Université de Liège.

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (07 August 2012). Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting. Electrophoresis, 33, 1669-1678. doi:10.1002/elps.201100621
Peer Reviewed verified by ORBi

Habyalimana, V., Mbinze Kindenge, J., Kadima Ntokamunda, J. L., Hubert, P., & Marini Djang'Eing'A, R. (July 2012). QUALITY ASSESSMENT OF MEDICINES MARKETED IN RWANDA, July-Oct. 2011. Paper presented at Symposium sur les médicaments traditionnels antipaludiques et l’analyse des médicaments et des toxiques Date(s) de la manifestation : 5-8 juillet 2012, Butare, Rwanda.

Tshisekedi Tshibangu, P., Kalenda Dibungi T., P., Wauters, J.-N., Tits, M., Frederich, M., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (July 2012). DEVELOPMENT AND VALIDATION OF A LC-UV METHOD FOR THE DOSAGE OF A TRACER IN AN IMPROVED TRADITIONAL MEDICINE. Paper presented at Symposium sur les médicaments traditionnels antipaludiques et l’analyse des médicaments et des toxiques, Butare, Rwanda.

Marini Djang'Eing'A, R., & Hubert, P. (2012). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament. (Rapport semestriel N°7, -). Liège, Belgium: ULg.

Hubert, C., Lebrun, P., Houari, S., Bakima, P., Rozet, E., Ziemons, E., & Hubert, P. (20 June 2012). First Application of an Innovative Design Space Optimization Strategy for the Development of a LC/MS Method. Poster session presented at 38th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Anaheim, United States - California.

Dispas, A., Lebrun, P., Hubert, C., Thiébaut, D., Vial, J., & Hubert, P. (June 2012). INNOVATIVE GREEN SUPERCRITICAL FLUID CHROMATOGRAPHY DEVELOPMENT FOR THE SEPARATION OF NEUROTRANSMITTERS USING DESIGN SPACE STRATEGY. Poster session presented at HPLC 2012, Anaheim, California, United States.

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, C., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (June 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NSAIDS. Poster session presented at HPLC 2012, Anaheim, California, United States.

Ziemons, E., De Bleye, C., Chavez, P.-F., Rozet, E., Lebrun, P., & Hubert, P. (10 May 2012). Development of near infrared spectroscopic methods using desirability indexes: How to select the most appropriate calibration model. Paper presented at EuPAT 5 - Fith pan-European QbD & PAT Science Conference, Ghent, Belgium.

Renard, J.-F., Lecomte, F., Arslan, D., Hubert, P., & Pirotte, B. (May 2012). Evaluation de l'impact au niveau pharmacocinétique de modulations structurales de N-(pyrid-4-yl)alcanesulfonamides. Poster session presented at 26èmes Journées franco-belges de pharmacochimie, Orléans, France.

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, P., & Marini Djang'Eing'A, R. (May 2012). THE DEVELOPMENT OF LC GENERIC ANALYTICAL METHODS TO FIGHT COUNTERFEIT NSAIDS USING DESIGN SPACE OPTIMISATION STRATEGY. Paper presented at 16ème FORUM DES SCIENCES PHARMACEUTIQUES, Blankenberge, Belgium.

Chavez, P.-F., Mantanus, J., Cuypers, S., Hubert, P., Ziemons, E., & Motte, H. (May 2012). Use of Near Infrared and Raman spectroscopy for the optimization of API layer of pharmaceutical tablet. Poster session presented at BPS Science Day, Braine-l'Alleud, Belgium.

Marini Djang'Eing'A, R., Lebrun, P., Rozet, E., & Hubert, P. (2012). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°5, -). Liège, Belgium: ULg.

Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkerberg, R., Streel, B., Evrard, B., & Hubert, P. (March 2012). AN INNOVATIVE APPROACH TO SELECT THE PREDICTION MODEL IN THE DEVELOPMENT OF NIR SPECTROSCOPIC METHODS. Poster session presented at AGROSTAT 2012, Paris, France.

Rozet, E., Boulanger, B., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (March 2012). SMALL SAMPLE SIZE CAPABILITY INDEX FOR ASSESSING VALIDITY OF ANALYTICAL METHODS. Poster session presented at AGROSTAT 2012, Paris, France.

Rozet, E., Govaerts, B., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (March 2012). RELIABILITY OF ANALYTICAL METHODS’ RESULTS: A BAYESIAN APPROACH TO ANALYTICAL METHOD VALIDATION. Paper presented at AGROSTAT 2012, Paris, France.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (February 2012). COMBINATION OF INDEPENDENT COMPONENT ANALYSIS, DESIGN OF EXPERIMENTS AND DESIGN SPACE FOR A NOVEL METHODOLOGY TO DEVELOP CHROMATOGRAPHIC METHODS. Poster session presented at 12th International Symposium on Hyphenated Techniques for Chromatography (HTC-12), Bruges, Belgium.

Rozet, E., Bouabidi, A., Talbi, M., Bouklouze, A., Bourichi, H., El Karbane, M., Boulanger, B., & Hubert, P. (February 2012). ARE CAPABILITY INDICES USEFULL TO ASSESS ANALYTICAL METHODS VALIDITY ? Poster session presented at 12th International Symposium on Hyphenated Techniques for Chromatography (HTC-12), Bruges, Belgium.

Rozet, E., Boulanger, B., & Hubert, P. (February 2012). QUALITY BY DESIGN COMPLIANT METHOD VALIDATION. Poster session presented at 12th International Symposium on Hyphenated Techniques for Chromatography (HTC-12), Bruges, Belgium.

Rozet, E., & Hubert, P. (10 January 2012). Validation of Analytical Methods.

Lecomte, F., Hubert, C., Demarche, S., De Bleye, C., Dispas, A., Jost, M., Frankenne, F., Ceccato, A., Rozet, E., & Hubert, P. (05 January 2012). Comparison of the quantitative performances and measurement uncertainty estimates obtained during method validation versus routine applications of a novel hydrophilic interaction chromatography method for the determination of cidofovir in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 57, 153-165. doi:10.1016/j.jpba.2011.08.040
Peer Reviewed verified by ORBi

Rozet, E., Ziemons, E., Marini Djang'Eing'A, R., Boulanger, B., & Hubert, P. (2012). Validation of analytical methods involved in dissolution assays: Acceptance limits and decision methodologies. Analytica Chimica Acta, 751, 44-51. doi:10.1016/j.aca.2012.09.017
Peer Reviewed verified by ORBi

Dias, A. L. S., Rozet, E., Chataigné, G., Oliveira, A. C., Rabelo, C. A. S., Hubert, P., Rogez, H., & Quetin-Leclercq, J. (2012). A rapid validated UHPLC–PDA method for anthocyanins quantification from Euterpe oleracea fruits. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 907, 108-116. doi:10.1016/j.jchromb.2012.09.015
Peer Reviewed verified by ORBi

Rozet, E., Ziemons, E., Marini Djang'Eing'A, R., Boulanger, B., & Hubert, P. (2012). Reply to the responses on the comments on “Uncertainty profiles for the validation of analytical methods” by Saffaj and Ihssane. Talanta, 100, 290-292. doi:10.1016/j.talanta.2012.07.047
Peer Reviewed verified by ORBi

Dias, A. L. S., Rozet, E., Chataigne, G., Oliveira, A. C., Silva, C. A. R., Hubert, P., Roger, H., & Quetin-Leclercq, J. (2012). A RAPID VALIDATED UHPLC-PDA METHOD FOR ANTHOCYANINS QUANTIFICATION FROM EUTERPE OLERACEA FRUITS. Poster session presented at The International Congress on Natural Products Research, New York City, United States.

Bouabidi, A., Ziemons, E., Marini Djang'Eing'A, R., Hubert, C., Talbi, M., Bourichi, H., El Karbane, M., Boulanger, B., Hubert, P., & Rozet, E. (2012). Usefulness of capability indices in the framework of analytical methods validation. Analytica Chimica Acta, 714, 47-56. doi:10.1016/j.aca.2011.11.019
Peer Reviewed verified by ORBi

AL-Kamarany, M. A., EL Karbane, M., Ridouan, K., Alanazi, F. K., Hubert, P., Cherrah, Y., & Bouklouze, A. (January 2012). Transfer of drug dissolution testing by statistical approaches: Case Study. Saudi Pharmaceutical Journal, 20 (1), 93–101. doi:10.1016/j.jsps.2011.08.006
Peer Reviewed verified by ORBi

Rozet, E., Ziemons, E., Marini Djang'Eing'A, R., Boulanger, B., & Hubert, P. (January 2012). Comments on “Uncertainty profiles for the validation of analytical methods” by Saffaj and Ihssane [letter to the editor]. Talanta, 88, 769-771. doi:10.1016/j.talanta.2011.11.011
Peer Reviewed verified by ORBi

Bourichi, H., Brik, Y., Hubert, P., Cherrah, Y., & Bouklouze, A. (2012). Solid -state characterization and impurities determination of Fluconazol generic products. Journal of Pharmaceutical Analysis. doi:10.1016/j.jpha.2012.05.007
Peer Reviewed verified by ORBi

De Bleye, C., Chavez, P.-F., Mantanus, J., Marini Djang'Eing'A, R., Hubert, P., Rozet, E., & Ziemons, E. (2012). Critical Review of Near-Infrared Spectroscopic Methods Validations in Pharmaceutical Applications. Journal of Pharmaceutical and Biomedical Analysis, 69, 125-132. doi:10.1016/j.jpba.2012.02.003
Peer Reviewed verified by ORBi

Rozet, E., Lebrun, P., Debrus, B., & Hubert, P. (2012). New Methodology for the development of chromatographic methods with bioanalytical application. Bioanalysis, 4 (7), 755-758. doi:10.4155/bio.12.47
Peer Reviewed verified by ORBi

Rozet, E., Ziemons, E., Marini Djang'Eing'A, R., Boulanger, B., & Hubert, P. (2012). Quality by design compliant analytical method validation. Analytical Chemistry, 84, 106-112. doi:10.1021/ac202664s
Peer Reviewed verified by ORBi

Lebrun, P., Krier, F., Mantanus, J., Grohganz, H., Yang, M., Rozet, E., Boulanger, B., Evrard, B., Rantanen, J., & Hubert, P. (2012). Design space approach in the optimization of the spray-drying process. European Journal of Pharmaceutics and Biopharmaceutics, 80 (1), 226-234. doi:10.1016/j.ejpb.2011.09.014
Peer Reviewed verified by ORBi

Bouabidi, A., Talbi, M., Bourichi, H., Bouklouze, A., El Karbane, M., Boulanger, B., Hubert, P., & Rozet, E. (2012). Flexibility and Applicability of β-expectation tolerance interval approach to assess the fitness of purpose of pharmaceutical analytical methods. Drug Testing and Analysis, 4 (12), 1014-1027. doi:10.1002/dta.1345
Peer Reviewed verified by ORBi

Rafamantanana, M. H., Debrus, B., Raoelison, G., Rozet, E., Lebrun, P., Uverg-Ratsimamanga, S., Hubert, P., & Quetin-Leclercq, J. (2012). APPLICATION OF DESIGN OF EXPERIMENTS AND DESIGN SPACE METHODOLOGY FOR THE HPLC-UV SEPARATION OPTIMIZATION OF APORPHINE ALKALOIDS FROM LEAVES OF Spirospermum penduliflorum THOUARS. Journal of Pharmaceutical and Biomedical Analysis, 62, 23-32. doi:10.1016/j.jpba.2011.12.028
Peer Reviewed verified by ORBi

Debrus, B., Rozet, E., Hubert, P., Veuthey, J.-L., Rudaz, S., & Guillarme, D. (2012). Chapter 3 Method Transfer Between Conventional HPLC and UHPLC. In D. Guillarme & J.-L. Veuthey (Eds.), UHPLC in Life Sciences (pp. 67-101). Royal Society of Chemistry. doi:10.1039/9781849735490-00067
Peer reviewed

Al-Kamarany, M. A., El Karbane, M., Belomaria, M., Azougagh, M., Hubert, P., Alanazi, F., Cherrah, Y., & Bouklouze, A. (2012). Development and Validation of LC Method for the Diclofenac Sodium Release Determination Using Accuracy Profile Concept. Asian Journal of Chemistry, 24 (10), 4393-4400.
Peer Reviewed verified by ORBi

Lautié, E., Rozet, E., Hubert, P., & Quetin-Leclercq, J. (2012). Quantification of rotenone in seeds of different species of yam bean (Pachyrhizus sp.) by a SPE HPLC-UV method. Food Chemistry, 131 (4), 1531-1538. doi:10.1016/j.foodchem.2011.09.125
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., & Hubert, P. (2011). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport annuel 2011, -). Liège, Belgium: ULg.

Houbart, V., COBRAIVILLE, G., Lecomte, F., Debrus, B., Hubert, P., & Fillet, M. (16 December 2011). Development of a nano-liquid chromatography on chip tandem mass spectrometry method for high-sensitivity hepcidin quantitation. Journal of Chromatography. A, 1218 (50), 9046-9054. doi:10.1016/j.chroma.2011.10.030
Peer Reviewed verified by ORBi

Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires. Paper presented at Chimiométrie 2011, Marseille, France.

Boulanger, B., Lebrun, P., Rozet, E., & Hubert, P. (29 November 2011). Design Space ou Espace de Conception. Paper presented at Liège Creative, Liege, Belgium.

Mantanus, J., Rozet, E., Van Butsele, K., De Bleye, C., Ceccato, A., Evrard, B., Hubert, P., & Ziemons, E. (October 2011). Silicone-based drug reservoirs manufacturing process - Critical quality attributes evaluation using NIR and Raman spectroscopy. Poster session presented at AAPS Annual Meeting and Exposition, Washington, United States.

Marini Djang'Eing'A, R., & Hubert, P. (2011). Rapport d'activités scientifiques du Projet Interuniversitaire Cible. (Rapport annuel N°1, -). Liège, Belgium: ULg.

Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2011). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°4, -). Liège, Belgium: ULg.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (08 September 2011). New Methodology for the Development of Chromatographic Methods. Paper presented at 17th International Symposium on Separation Sciences – ISSS 2011, Cluj, Romania.

Rozet, E., & Hubert, P. (08 September 2011). NEW TRENDS IN VALIDATION OF ANALYTICAL METHODS. Paper presented at 18th International Symposium on Electro- and Liquid Phase-separation Techniques – ITP 2011, Tbilisi, Georgia.

Marini Djang'Eing'A, R., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Lamalle, C., Fillet, M., Rudaz, S., & Hubert, P. (September 2011). IMPLEMENTATION OF GENERIC ANALYTICAL METHODS TO FIGHT AGAINST COUNTERFEIT MEDICINES. Paper presented at Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Rozet, E., Marini Djang'Eing'A, R., Lebrun, P., Ziemons, E., Boulanger, B., & Hubert, P. (September 2011). A BAYESIAN PREDICTIVE PROBABILITY CRITERION TO ASSESS ANALYTICAL METHODS VALIDITY. Poster session presented at Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (September 2011). GENERIC MEKC METHOD FOR THE SEPARATION OF 15 ANTIMALARIAL DRUGS. Poster session presented at Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

De Bleye, C., Mantanus, J., Rozet, E., Van Butsele, K., Marini Djang'Eing'A, R., Ceccato, A., Evrard, B., Hubert, P., & Ziemons, E. (September 2011). BUILDING THE QUALITY INTO THE POLYMERIC SOLID DOSAGE FORM MANUFACTURING LINE - CRITICAL QUALITY ATTRIBUTES EVALUATION WITH NIR AND RAMAN PAT TOOLS. Poster session presented at Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Rozet, E., & Hubert, P. (2011). Rapport annuel du projet "Prédiction des risques associés aux résultats générés par les méthodes analytiques au cours des étapes de leur cycle de vie.". (3).

Marini Djang'Eing'A, R., & Hubert, P. (2011). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport semestre 5). Liège, Belgium: ULg.

Hubert, C., Ziemons, E., & Hubert, P. (2011). LCA-GE-005- Rapport de validation - VR001_V01.

Houbart, V., Lecomte, F., COBRAIVILLE, G., Servais, A.-C., Hubert, P., & Fillet, M. (20 June 2011). Development and Prevalidation of a Nano-LC-Chip-MS/MS Method for High Sensitivity Hepcidin Quantitation. Poster session presented at 36th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Budapest, Hungary.

Hubert, C., Streel, B., Sibenaler, R., Widart, J., Ceccato, A., & Hubert, P. (19 June 2011). High Throughput determination of Levonorgestrel in human plasma using a Sensitive LC-MS/MS method. Poster session presented at 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Budapest, Hungary.

Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Krier, F., Evrard, B., & Hubert, P. (June 2011). La spectroscopie vibrationnelle, outil indispensable pour l'industrie pharmaceutique ?

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Servais, A.-C., Crommen, J., Hubert, P., & Fillet, M. (June 2011). Development of a Generic MEKC Method for the Separation of 15 Antimalarial Drugs by a Design Space Approach. Poster session presented at 36th International symposium on HPLC and Related Techniques, Budapest, Hungary.

Hubert, C., Ziemons, E., & Hubert, P. (2011). Protocole d'essai LC/MS - P001 - V01.

Jost, M., Frankenne, F., Maillard, C., Hubert, P., Herman, L., Delvenne, P., Piette, M., Coia, I., Evrard, B., Lecomte, F., Hubert, P., Englert, Y., Bossens, M., van Pachterbeke, C., GOFFIN, F., Doyen, J., Kridelka, F., Snoeck, R., & FOIDART, J.-M. (20 May 2011). From the Clinics to the Bench and back to the Clinics: design of a medical treatment for Cervical Intraepithelial Neoplasia (CIN). Paper presented at GIGA-Cancer Day, Liège, Belgium.

Mantanus, J., Rozet, E., Lebrun, P., Evrard, B., Hubert, P., & Ziemons, E. (19 May 2011). Une solution analytique verte pour le PAT: la spectroscopie proche infrarouge. Paper presented at Chimie analytique verte: chromatographie en phase supercritique, liquides ioniques, haute température et miniaturisation, Paris, France.

Hubert, C., Ziemons, E., & Hubert, P. (2011). Qualitative analysis of potentials compounds contained in an aged matrix of a pharmaceutical speciality at the RT of an impurity.

Hubert, C., Ziemons, E., & Hubert, P. (2011). Rapport de validation LC/MS - PVR-001 - V02.

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (May 2011). Conception, synthèse et évaluation pharmacologique de N-(pyridin-4-yl)alcanesulfonamides en tant qu'inhibiteurs de cyclooxygénases. Poster session presented at XVèmes Journées Franco-belges de pharmacochimie, Liège, Belgium.

Ziemons, E., Frederich, M., Fillet, M., Hubert, P., & Quetin-Leclercq, J. (May 2011). Espectroscopia aplicada. Paper presented at Maestra en Ciencia y Tecnologia de Productos Naturales, Cochabamba, Bolivia.

Lebrun, P., Boulanger, B., & Hubert, P. (29 April 2011). Validation and Routine of Ligand-Binding Assays, a Bayesian Perspective. Paper presented at Bayes 2011, Louvain-la-Neuve, Belgium.

Rozet, E., & Hubert, P. (04 April 2011). Comment adéquatement déclarer valide ou non valide une méthode analytique ? Paper presented at Journées "Mesures, Normes et Statistique", Montpellier, France.

Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2011). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°3, -). Liège, Belgium: ULg.

Hubert, C., Ziemons, E., & Hubert, P. (2011). Comparison between new and old excipients.

Ziemons, E., Rozet, E., & Hubert, P. (2011). Développement d'une méthodologie statistique basée sur l'intervalle de tolérance pour la sélection et l'évaluation de modèles robustes dans le domaine de la spectroscopie et de l'imagerie proche infrarouge. (Evaluation ex-post).

Lebrun, P., Boulanger, B., Hubert, P., Mbinze Kindenge, J., & Debrus, B. (02 March 2011). Design Space and desirability index. A Bayesian predictive risk-based approach to flexibly achieve multi-criteria decision methods. Paper presented at The Second International Symposium on Biopharmaceutical Statistics, Berlin, Germany.

Debrus, B., Broséus, J., Guillarme, D., Lebrun, P., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (March 2011). Innovative methodology to transfer conventional GC-MS heroin profiling to UHPLC-MS/MS. Analytical and Bioanalytical Chemistry, 399 (8), 2719-2730. doi:10.1007/s00216-010-4282-7
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2011). Contrôle qualité. 15e Jour du Mois.

Marini Djang'Eing'A, R., & Hubert, P. (2011). Rapport d'activités scientifiques du Projet Interuniversitaire Cible. (Rapport N°1, -). Liège, Belgium: Ulg.

Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2011). Le fléau des faux médicaments. Eprint/Working paper retrieved from https://orbi.uliege.be/2268/84930.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Nistor, I., Oprean, R., Rupérez, F. J., Barbas, C., Boulanger, B., & Hubert, P. (2011). Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography. Analytica Chimica Acta, 691, 33-42. doi:10.1016/j.aca.2011.02.035
Peer Reviewed verified by ORBi

Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Rozet, E., Oprean, R., Badarau, E., Dufour, F., Liégeois, J.-F., & Hubert, P. (2011). Implementation of a design space approach for enatiomeric separations in polar organic solvent chromatography. Poster session presented at 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Budapest, Hungary.

Nistor, I., Cao, M., Debrus, B., Lebrun, P., Lecomte, F., Rozet, E., Angenot, L., Frederich, M., Oprean, R., & Hubert, P. (2011). Application of a new optimization strategy for the separation of tertiary alkaloids extracted from Strychnos usambarensis leaves. Journal of Pharmaceutical and Biomedical Analysis, 56, 30-37. doi:10.1016/j.jpba.2011.04.027
Peer Reviewed verified by ORBi

Mantanus, J., Rozet, E., Van Butsele, K., De Bleye, C., Ceccato, A., Evrard, B., Hubert, P., & Ziemons, E. (2011). Near infrared and Raman spectroscopy as Process Analytical Technology tools for the manufacturing of silicone-based drug reservoirs. Analytica Chimica Acta, 699, 96-106. doi:10.1016/j.aca.2011.05.006
Peer Reviewed verified by ORBi

Debrus, B., & Hubert, P. (2011). Introduction à la chromatographie liquide. (ULiège - Université de Liège).

Rozet, E., Govaerts, B., Lebrun, P., Michail, K., Ziemons, E., Wintersteiger, R., Rudaz, S., Boulanger, B., & Hubert, P. (2011). Evaluating the reliability of analytical results using a probability criterion: a Bayesian perspective. Analytica Chimica Acta, 705, 193-206. doi:10.1016/j.aca.2011.05.028
Peer Reviewed verified by ORBi

Rozet, E., Marini Djang'Eing'A, R., Ziemons, E., Boulanger, B., & Hubert, P. (2011). Advances in validation, risk and uncertainty assessment of bioanalytical methods. Journal of Pharmaceutical and Biomedical Analysis, 55, 848-858. doi:10.1016/j.jpba.2010.12.018
Peer Reviewed verified by ORBi

Bouabidi, A., Talbi, M., Bouklouze, A., El Karbane, M., Bourichi, H., El Guezzar, M., Ziemons, E., Hubert, P., & Rozet, E. (2011). DO PLACEBO BASED VALIDATION STANDARDS MIMIC REAL BATCH PRODUCTS BEHAVIOUR? CASE STUDIES. Journal of Pharmaceutical and Biomedical Analysis, 55, 583-590. doi:10.1016/j.jpba.2011.02.008
Peer Reviewed verified by ORBi

Ziemons, E., Bourichi, H., Mantanus, J., Rozet, E., Lebrun, P., Essassi, E., Cherrah, Y., Bouklouze, A., & Hubert, P. (2011). Determination of binary polymorphic mixtures of fluconazole using near infrared spectroscopy and X-ray powder diffraction: A comparative study based on the pre-validation stage results. Journal of Pharmaceutical and Biomedical Analysis, 55, 1208-1212. doi:10.1016/j.jpba.2011.02.019
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Mbinze Kindenge, J., Lecomte, F., Ceccato, A., Caliaro, G., Mavar Tayey Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2011). Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space. Journal of Chromatography. A, 1218, 5205-5215. doi:10.1016/j.chroma.2011.05.102
Peer Reviewed verified by ORBi

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (2011). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities. Journal of Pharmaceutical and Biomedical Analysis, 54, 694-700. doi:10.1016/j.jpba.2010.10.022
Peer Reviewed verified by ORBi

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (January 2011). Pyridine Derivatives of Nimesulide as New Promising Anti-inflammatory Agents. Poster session presented at Giga Days, Liège, Belgium.

Rozet, E., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., Boulanger, B., & Hubert, P. (2011). Models to estimate overall analytical measurements uncertainty: assumptions, comparisons and applications. Analytica Chimica Acta, 702, 160-171. doi:10.1016/j.aca.2011.06.055
Peer Reviewed verified by ORBi

ZIME DIAWARA, H., GBAGUIDI, F., Evrard, B., Quetin-Leclercq, J., MOUDACHIROU, M., Debrus, B., Hubert, P., & Rozet, E. (2011). Validation, transfer and measurement uncertainty estimation of an HPLC-UV method for the quantification of artemisinin in hydro alcoholic extracts of Artemisia annua L. Journal of Pharmaceutical and Biomedical Analysis, 56, 7-15. doi:10.1016/j.jpba.2011.04.012
Peer Reviewed verified by ORBi

Rozet, E., Dewe, W., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., Boulanger, B., & Hubert, P. (2011). Total Error and Uncertainty: Friends or Foes? TrAC: Trends in Analytical Chemistry, 30 (5), 797-806. doi:10.1016/j.trac.2010.12.009
Peer Reviewed verified by ORBi

Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Moonen, F., Evrard, B., & Hubert, P. (08 December 2010). Vibrational spectroscopy in pharmaceutical industry: From development of the most appropriate predictive model to routine implementation. Poster session presented at BioWin Day 2010, Louvain-la-Neuve, Belgium.

Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Evrard, B., Moonen, F., & Hubert, P. (02 December 2010). Use of tolerance intervals in the development of near infrared spectroscopic methods: An innovative way to select the most appropriate calibration model. Poster session presented at Chimiométrie 2010, Paris, France.

Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (02 December 2010). Evaluating analytical results reliability using a Bayesian probability criterion. Poster session presented at Congrès Chimimétrie 2010, Paris, France.

Ziemons, E., & Hubert, P. (2010). Introduction à la spectroscopie Raman. (ULiège - Université de Liège, CHIM0330-1 - Chimie Analytique (Partim I)).

Lebrun, P., Lambert, P., Debrus, B., Hubert, P., Marini Djang'Eing'A, R., Moonen, F., & Boulanger, B. (December 2010). Developing and optimizing analytical chromatographic method in a Quality by Design environment. Bayesian multi-criteria risk-based Design Space to guarantee future quality. Poster session presented at Chimiométrie 2010, Paris, France.

Marini Djang'Eing'A, R., Rozet, E., Montes De Lourdes Aja, M., Rohrbasser, C., Roht, S., Rhème, D., Bonnabry, P., Veuthey, J.-L., Hubert, P., & Rudaz, S. (December 2010). Reliable low cost capillary electrophoresis device for drug quality control and counterfeit medicines. Journal of Pharmaceutical and Biomedical Analysis, 53 (5), 1278 - 1287. doi:10.1016/j.jpba.2010.07.026
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., & Hubert, P. (2010). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport annuel 2, -). Liège, Belgium: ULg.

Ziemons, E., Sacre, P.-Y., & Hubert, P. (2010). Spectroscopie vibrationnelle dans le cadre du PAT - Des aspects qualitatifs à la quantification en ligne. (ULiège - Université de Liège, PHIN2022-1 Production industrielle des formes pharmaceutiques).

Ziemons, E., Rozet, E., & Hubert, P. (2010). Développement d'une méthodologie statistique basée sur l'intervalle de tolérance pour la sélection et l'évaluation de modèles robustes dans le domaine de la spectroscopie et de l'imagerie proche infrarouge. (4eme semestre).

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (15 November 2010). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities. Poster session presented at The FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting & Exposition, new orléans, United States.

Mantanus, J., Ziemons, E., Streel, B., Klinkenberg, R., Evrard, B., Rantanen, J., & Hubert, P. (15 November 2010). NIR monitoring of solid and liquid forms manufacturing – Development and validation of in-line quantitative methods. Poster session presented at FIP Pharmaceutical Sciences 2010 world congress, New Orleans, United States.

Lebrun, P., Boulanger, B., & Hubert, P. (04 November 2010). How can QbD be used and implemented to optimize method development and validation? Paper presented at Biological Assay Conference (Informa), London, United Kingdom.

Boulanger, B., Govaerts, B., Le Boulengé, E., Lebrun, P., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Plans expérimentaux. (ULiège - Université de Liège).

Tiuca, I., Mantanus, J., Iacob, B., Ede, B., Oprean, R., Hubert, P., & Ziemons, E. (November 2010). Raman spectroscopic study of complex formation between major calixarene derivatives and three pharmaceutical substances. Poster session presented at Jours de l’Université de Médecine et Pharmacie „Iuliu Haţieganu”, Cluj-Napoca, Romania.

Hubert, C., Ziemons, E., & Hubert, P. (2010). Report of the development of a LC-MS method for the assay of an impurity in a pharmaceutical speciality.

Mantanus, J., Lebrun, P., Rozet, E., Evrard, B., Hubert, P., & Ziemons, E. (14 October 2010). La spectroscopie proche infrarouge et Raman: Nouvelles armes vertes dans le contrôle de la qualité du médicament. Poster session presented at Journée Scientifique Annuelle de la Société Royale de Chimie: Chimie Verte, Gembloux, Belgium.

Hubert, P., Ziemons, E., Mantanus, J., Lebrun, P., Boulanger, B., & Rozet, E. (October 2010). RISK MANAGMENT IN THE VALIDATION OF ANALYTICAL METHODS. Paper presented at CNFR 2010 Congress, Targu-Mures, Romania.

Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (October 2010). Analytical results reliability using a probability criterion: a Bayesian perspective. Poster session presented at Chemometrics in Analytical Chemistry, Antwerpen, Belgium.

Lebrun, P., Boulanger, B., & Hubert, P. (28 September 2010). Optimization of ligand-binding assay in a QbD environment. Use of Bayesian non-linear regression to set up probability profile as quality response. Paper presented at Non clinical statistics conference, Lyon, France.

Mantanus, J., Ziemons, E., Van Butsele, K., Evrard, B., Ceccato, A., & Hubert, P. (24 September 2010). NIR AND RAMAN SPECTROSCOPY AS PAT TOOLS FOR THE MANUFACTURING OF SILICONE-BASED DRUG RESERVOIRS. Paper presented at Drug Analysis 2010, Anvers, Belgium.

Nistor, I., Debrus, B., Lebrun, P., Cao, M., Frederich, M., Angenot, L., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design space for the separation of compounds extracted from the leaves of Strychnos usambarensis. Paper presented at Drug Analysis 2010, Antwerpen, Belgium.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design for the separation of compounds extracted from the leaves of Strychnos Usambarensis. Poster session presented at Drug analysis 2010, Antwerpen, Belgium.

Nistor, I., Lecomte, F., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Marini Djang'Eing'A, R., Oprean, R., & Hubert, P. (September 2010). Transfer of a conventional LC method for the screening of conterfeit antimalarial medicines to UHPLC. Poster session presented at Drug analysis 2010, Antwerpen, Belgium.

Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (September 2010). Implementation of design space concept for the development of robust analytical methods. Poster session presented at Drug Analysis 2010, Anvers (Antwerp), Belgium.

Houbart, V., Lecomte, F., Cobraiville, G., Crommen, J., Hubert, P., & Fillet, M. (September 2010). A LC-chip nanoelectrospray MS/MS method for hepcidin quantitation in human plasma. Poster session presented at 9th International Symposium on Drug Analysis - 22nd International Symposium on Pharmaceutical and Biomedical Analysis, Antwerp, Belgium.

Marini Djang'Eing'A, R., Mbinze Kindenge, J., Montes, M. L. A., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Rudaz, S., & Hubert, P. (September 2010). Contribution to fight against counterfeit medecines applying several analytical tools. Poster session presented at International Symposium on Drug Analysis 2010, Anvers, Belgium.

Bouabidi, A., Talbi, M., Bouklouze, A., Ziemons, E., Rozet, E., & Hubert, P. (September 2010). Does placebo based validation standards mimic well real batch products behaviour? A case study. Poster session presented at Drug Analysis 2010, Antwerpen, Belgium.

Lautié, E., Rozet, E., Hubert, P., & Quetin-Leclercq, J. (September 2010). A VALIDATED METHOD COMBINING SPE and HPLC-UV FOR THE QUANTIFICATION OF ROTENONEIN SEEDS OF YAM BEAN (PACHYRHIZUS SP.). Poster session presented at Drug Analysis, Anvers, Belgium.

Rozet, E., Boulanger, B., Dewe, Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (September 2010). Total error as natural decision criteria for analytical methods validation and transfer. Paper presented at Drug Analysis 2010, Antwerpen, Belgium.

Marini Djang'Eing'A, R., Lambert, V., Denooz, R., Charlier, C., Hubert, C., Hubert, P., & Rozet, E. (September 2010). TOLERANCE INTERVALS AS CONTROL CHART: COMPARISON TO CLASSIC SHEWHART X̅-R CONTROL CHART. Poster session presented at International Symposium on Drug Analysis 2010, Anvers, Belgium.

Rafamantanana, M. H., Debrus, B., Raoelison, G. E., Uverg-Ratsimamanga, S., Hubert, P., & Quetin-Leclercq, J. (September 2010). Application of experimental design for the HPLC-UV-MS separation of aporphine alkaloids from leaves of Spirospermum Penduliflorum thouars. Poster session presented at Drug Analysis 2010, Antwerp, Belgium.

Dubois, N., Debrus, B., Hubert, P., & Charlier, C. (September 2010). Validated quantitative simultaneous determination of cocaine, opiates and amphetamines in serum by UHPLC-MS/MS. Poster session presented at Drug Analysis 2010, Antwerp, Belgium.

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Evrard, B., & Hubert, P. (September 2010). Optimisation and validation of a fast HPLC method for the quantitation of sulindac and its impurities. Poster session presented at Drug Analysis 2010, Anvers (Antwerp), Belgium.

Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (September 2010). An innovative approach to select the prediction model in the development of NIR spectroscopy methods. Poster session presented at Drug Analysis, Antwerpen, Belgium.

Lecomte, F., Jasselette, C., Hubert, C., Demarche, S., De Bleye, C., Ceccato, A., Rozet, E., & Hubert, P. (September 2010). Validation of a HILIC method for the determination of cidofovir in plasma. Poster session presented at Drug Analysis 2010 - International Symposium on Drug Analysis, Antwerp, Belgium.

Marini Djang'Eing'A, R., Mbinze Kindenge, J., Montes, M. L. A., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Rohrbasser, C., Rudaz, S., & Hubert, P. (September 2010). Analytical tools to fight against counterfeit medicines. Chimica Oggi, 28 (5), 10-14.
Peer Reviewed verified by ORBi

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Servais, A.-C., Crommen, J., Hubert, P., & Fillet, M. (September 2010). A DESIGN SPACE APPROACH TO DEVELOP A GENERIC CE METHOD FOR THE SEPARATION OF 19 ANTIMALARIAL DRUGS. Poster session presented at International Symposium on Drug Analysis, Anvers, Belgium.

Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Nettoyage des équipements et validation de nettoyage. (ULiège - Université de Liège).

Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Out Of Specification ou Non-Conformité. (ULiège - Université de Liège).

Marini Djang'Eing'A, R., Mbinze Kindende, J., Lecomte, F., Debrus, B., Lebrun, P., Rozet, E., Mantanus, J., Ziemons, E., & Hubert, P. (31 July 2010). La contrefaçon des médicaments : outils pour lutter contre ce fléau. Paper presented at Conférence Scientifique, Kisangani, Province Orientale, Congo - Kinshasa.

Rozet, E., & Hubert, P. (2010). Rapport annuel du projet "Prédiction des risques associés aux résultats générés par les méthodes analytiques au cours des étapes de leur cycle de vie.". (2).

Marini Djang'Eing'A, R., & Hubert, P. (2010). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport semestre 3, -). Liège, Belgium: ULg.

Ziemons, E., Rozet, E., & Hubert, P. (2010). Développement d'une méthodologie statistique basée sur l'intervalle de tolérance pour la sélection et l'évaluation de modèles robustes dans le domaine de la spectroscopie et de l'imagerie proche infrarouge. (3eme semestre).

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (21 May 2010). Nouveaux agents anti-inflammatoires en série N-(4-pyridyl)alcanesulfonamide. Paper presented at 24èmes JOURNEES FRANCO-BELGES DE PHARMACOCHIMIE, Woluwé-Saint-Lambert, Belgium.

Mantanus, J., Ziemons, E., Streel, B., Klinkenberg, R., Evrard, B., Rantanen, J., & Hubert, P. (05 May 2010). NIR as a PAT tool for solid and liquid forms manufacturing - Development and validation of in-line quantitative methods. Poster session presented at 4th Pan European Pat Science conference, Kuopio, Finland.

Mantanus, J., Ziemons, E., Evrard, B., Van Butsele, K., Ceccato, A., & Hubert, P. (05 May 2010). NIR Real-time monitoring of a silicone-based drug reservoir crosslinking process. Poster session presented at 4th Pan European Pat Science conference, Kuopio, Finland.

Lebrun, P., Boulanger, B., Rozet, E., & Hubert, P. (May 2010). Bayesian hierarchical linear regression for the validation of analytical methods. Paper presented at PhD days 2010, Gembloux, Belgium.

Ziemons, E., Ceccato, A., & Hubert, P. (2010). Utilisation de la spectroscopie proche infrarouge dans la cadre de la fabrication d'un dispositif intra-utérin. (3eme semestre & Final).

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (09 April 2010). Suggested mechanism of action of classical and deformable liposomes through pig ear skin. Paper presented at Perspectives in Percutaneous Penetration 2010 12th International Conference, La Grande Motte, France.

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (29 March 2010). Classical and deformable liposomes: possible mechanism of penetration through pig ear skin. Poster session presented at 8th International Conference and Workshop on Biological Barriers, Saarbrücken, Germany.

Marini Djang'Eing'A, R., Rozet, E., Hubert, C., Ziemons, E., & Hubert, P. (March 2010). Estimation of uncertainty from the total error strategy: Application to internal and normative methods. Acta Clinica Belgica, 65, 100-104.
Peer Reviewed verified by ORBi

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Martine, C., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (26 January 2010). Optimisation de la séparation des alcaloïdes extraits des feuilles de Strychnos usambarensis au moyen du design space. Paper presented at Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium.

Hubert, C., Houari, S., Lecomte, F., Houbart, V., De Bleye, C., Fillet, M., Piel, G., Rozet, E., & Hubert, P. (26 January 2010). Développement et validation d'une méthode de dosage de la glucosamine par SPE/LC/MS dans le plamsa canin. Paper presented at Forum des jeunes chercheurs du C.I.R.M, Liège, Belgium.

Lecomte, F., Hubert, C., Rozet, E., & Hubert, P. (26 January 2010). Intérêt de la chromatographie en mode HILIC pour le dosage du cidofovir dans des fluides biologiques. Paper presented at Forum des jeunes chercheurs du CIRM - 26 janvier 2010 - ULg, Liège, Belgium.

Ziemons, E., Mantanus, J., Lebrun, P., Rozet, E., Evrard, B., & Hubert, P. (2010). Acetaminophen determination in low-dose pharmaceutical syrup by NIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 53, 510-516. doi:10.1016/j.jpba.2010.06.003
Peer Reviewed verified by ORBi

Dubois, N., Debrus, B., Hubert, P., & Charlier, C. (2010). Validated quantitative simultaneous determination of cocaine opiates and amphetamines in serum by U-HPLC coupled to tandem mass spectrometry. Acta Clinica Belgica, 65 (1), 75-84. doi:10.1179/acb.2010.113
Peer Reviewed verified by ORBi

Cavalier, E., Rozet, E., Carlisi, I., Bekaert, A.-C., Rousselle, O., Hubert, P., Chapelle, J.-P., & Delanaye, P. (January 2010). Analytical validation of the BAP OSTASE on Liaison (DiaSorin). Clinical Chemistry and Laboratory Medicine, 48 (1), 67-72. doi:10.1515/CCLM.2010.019
Peer Reviewed verified by ORBi

Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2010). Active content determination of non-coated pharmaceutical pellets by near infrared spectroscopy: Method development, validation and reliability evaluation. Talanta, 80, 1750-1757. doi:10.1016/j.talanta.2009.10.019
Peer Reviewed verified by ORBi

Hubert, C., Ziemons, E., Rozet, E., Breuer, A., Lambert, A., Jasselette, C., De Bleye, C., Lejeune, R., & Hubert, P. (January 2010). Development and validation of a quantitative method for the selective determination of tin species in tin octoate by differential pulse polarography. Talanta, 80 (3), 1413-1420. doi:10.1016/j.talanta.2009.09.045
Peer Reviewed verified by ORBi

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (2010). Suggested mechanism of action of classical and deformable liposomes through pig ear skin. Journal of Pharmacy and Pharmacology, 62 (6), 788-807.
Peer Reviewed verified by ORBi

Rozet, E., & Hubert, P. (2010). Transfert des méthodes analytiques. (ULiège - Université de Liège, Formation Continuée Pharmacien d'Industrie).

Mantanus, J., Ziemons, E., Rozet, E., Streel, B., Klinkenberg, R., Evrard, B., Rantanen, J., & Hubert, P. (2010). Building the quality into pellet manufacturing environment - feasibility study and validation of an in-line quantitative near infrared (NIR) method. Talanta, 83, 305-311. doi:10.1016/j.talanta.2010.09.009
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (2010). Development of robust analytical methods using design space methodology. Poster session presented at Chimiométrie 2010, Paris, France.

Rozet, E., Staes, E., Ucakar, B., Hubert, P., & Preat, V. (2010). Validation of a method for the quantitation of ghrelin and unacylated ghrelin by HPLC. Journal of Pharmaceutical and Biomedical Analysis, 51 (3), 633-9. doi:10.1016/j.jpba.2009.09.040
Peer Reviewed verified by ORBi

Rozet, E., Bouabidi, A., Fillet, M., Ziemons, E., Chapuzet, E., Mertens, B., Klinkenberg, R., Ceccato, A., Talbi, M., Streel, B., Bouklouze, A., Boulanger, B., & Hubert, P. (2010). Critical analysis of several analytical method validation strategies in the framework of the fit for purpose concept. Journal of Chromatography. A, 1217, 3180-3192. doi:10.1016/j.chroma.2009.08.051
Peer Reviewed verified by ORBi

Hubert, C., Houari, S., Lecomte, F., Houbart, V., De Bleye, C., Fillet, M., Piel, G., Rozet, E., & Hubert, P. (2010). Development and validation of a sensitive solid phase extraction/hydrophilic interaction liquid chromatography/mass spectrometry method for the accurate determination of glucosamine in dog plasma. Journal of Chromatography. A, 1217, 3275-3281. doi:10.1016/j.chroma.2010.01.024
Peer Reviewed verified by ORBi

Cavalier, E., Rozet, E., Gadisseur, R., Carlisi, I., Monge, M., Chapelle, J.-P., Hubert, P., Souberbielle, J.-C., & Delanaye, P. (2010). Measurement uncertainty of 25-OH vitamin D determination with different commercially available kits: impact on the clinical cut offs. Osteoporosis International, 21, 1047-1051. doi:10.1007/s00198-009-1052-5
Peer Reviewed verified by ORBi

Ziemons, E., & Hubert, P. (2010). Activités de recherche du laboratoire de Chimie Analytique. Paper presented at Forum des Seniors, Liège, Belgium.

Fotsing, L., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Audits de qualités des fournisseurs de produits pharmaceutiques: Aspects théoriques et pratiques. (ULiège - Université de Liège).

Bonnard, E., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Bonnes Pratiques de Fabrication - Good Manufacturing Practice. (ULiège - Université de Liège).

Michail, K., Rozet, E., Hubert, P., & Wintersteiger, R. (2010). A double-cartridge SPE-HPLC-UV method for monitoring a humanfriendly anticancer in plasma: Ketoglutarate levels in metastatic carcinoma. Poster session presented at BioVisionAlexandria, Alexandrie, Belgium.

Hubert, P. (2010). Sensibilisation au management de la qualité. (ULiège - Université de Liège, Formation RQLab ULg).

Rafamantanana, M. H., Rozet, E., Raoelison, G. E., Cheuk, K., Ratsimamanga, M. H., Hubert, P., & Quetin-Leclercq, J. (2010). Simultaneous quantification os asiaticoside, asiatic acid, madecassoside and madecassic acid in leaves of Centella asiatica (L.) urb. Poster session presented at 11th international symposium on hyphenated techniques in chromatography and hyphenated chromatographic analyses, Bruges, Belgium.

Ziemons, E., Sacre, P.-Y., Evrard, B., & Hubert, P. (2010). Process Analytical Technology (PAT) - Technologie de contrôle des Procédés. (ULiège - Université de Liège, PHIN2022-1 Production industrielle des formes pharmaceutiques).

De Backer, B., Debrus, B., Lebrun, P., Theunis, L., Dubois, N., Decock, L., Verstraete, A., Hubert, P., & Charlier, C. (08 December 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (32), 4115-4124. doi:10.1016/j.jchromb.2009.11.004
Peer Reviewed verified by ORBi

Ziemons, E., Moonen, F., & Hubert, P. (03 December 2009). Analysing spectral data for the selection of a calibration model.

Cavalier, E., Delanaye, P., Hubert, P., Krzesinski, J.-M., Chapelle, J.-P., & Rozet, E. (December 2009). Estimation of the Stability of Parathyroid Hormone when Stored at -80°C for a Long Period. Clinical Journal of the American Society of Nephrology, 4 (12), 1988-92. doi:10.2215/CJN.03970609
Peer Reviewed verified by ORBi

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (December 2009). Application de la planification expérimentale et du design space pour la séparation des composés extraits des feuilles de Strychnos usambarensis. Poster session presented at 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France.

Lecomte, F., Demarche, S., Evrard, S., Delaunay, S., Hubert, C., Rozet, E., & Hubert, P. (01 December 2009). Intérêt de la chromatographie liquide d'interactions hydrophiles pour l'analyse de composés polaires dans des matrices complexes. Paper presented at 8ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages - SEP09, Marseille, France.

Mbinze Kindenge, J., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Lecomte, F., Boulanger, B., & Hubert, P. (December 2009). Développement d’une méthode pour la séparation de 19 antipaludéens par HPLC au moyen de la planification expérimentale et du Design Space. Poster session presented at 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France.

Hubert, C., Houari, S., Lecomte, F., Houbart, V., De Bleye, C., Fillet, M., Piel, G., Rozet, E., & Hubert, P. (01 December 2009). Développement et validation d'une méthode de dosage de la glucosamine par SPE/HILIC/MS dans le plamsa de chien. Poster session presented at 8ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Marseille, France.

Marini Djang'Eing'A, R., & Hubert, P. (2009). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport annuel 1, -). Liège, Belgium: ULg.

Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2009). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°2, -). Liège, Belgium: ULg.

Ziemons, E., Rozet, E., & Hubert, P. (2009). Développement d'une méthodologie statistique basée sur l'intervalle de tolérance pour la sélection et l'évaluation de modèles robustes dans le domaine de la spectroscopie et de l'imagerie proche infrarouge. (2ème semestre).

Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., & Hubert, P. (November 2009). Active content determination of non-coated pharmaceutical pellets by near infrared spectroscopy: Method development, validation and reliability evaluation. Poster session presented at Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, Los Angeles, United States.

Hubert, C., Ziemons, E., & Hubert, P. (2009). Rapport final de développement et de validation de l'étain dans l'octanoate d'étain.

De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (October 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Poster session presented at 4èmes journées internationales de Toxicologie, Liège, Belgium.

De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (October 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Paper presented at 4èmes journées internationales de Toxicologie, Liège, Belgium.

Debrus, B., Broséus, J., Guillarme, D., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (October 2009). Implementation of new Fast-GC-MS and UHPLC-MS/MS data in a conventional GC-MS database for heroin profiling. Paper presented at 4èmes journées internationales de toxicologie hospitalière, Liège, Belgium.

Marini Djang'Eing'A, R., Rozet, E., Hubert, C., Ziemons, E., & Hubert, P. (October 2009). Estimation de l’incertitude à partir de la stratégie de l’erreur totale : Application pour des méthodes internes et des méthodes normatives. Poster session presented at 4ème journées internationales de Toxicologie, Liège, Belgium.

Hubert, P., & Marini Djang'Eing'A, R. (2009). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament. Paper presented at Lancement officielle du Projet EDULINK DEV-AQM en République Démocratique du Congo, Kinshasa, Congo - Kinshasa.

Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2009). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°1, -). Liège, Belgium: ULg.

Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Rudaz, S., Klinkenberg, R., Streel, B., & Hubert, P. (September 2009). Validation of a near infrared spectroscopy method for the quantitative determination of an active ingredient in non-coated pharmaceutical pellets. Poster session presented at 13th International Meeting of Recent Developments in Pharmaceutical Analysis, Milan, Italy.

Mantanus, J., Ziemons, E., Streel, B., Klinkenberg, R., Evrard, B., Hubert, P., & Rantanen, J. (September 2009). Production line real time near infrared (NIR) monitoring. Paper presented at 3rd Annual Pharmaceutical Solid State Research Cluster Symposium, Copenhagen, Denmark.

Hubert, P., Ziemons, E., & Rozet, E. (2009). Validation des méthodes d'analyse pharmaceutique et biopharmaceutique. (ULiège - Université de Liège, PHAR0713-A-a).

De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (August 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material. Poster session presented at 47ème meeting de l'International Association of Forensic Toxicologists (TIAFT), Genève, Switzerland.

Debrus, B., Broséus, J., Guillarme, D., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (August 2009). Transfer of heroin profiling method from conventional GC-MS to Fast-GC-MS and UHPLC-MS/MS. Paper presented at TIAFT 2009, Genève, Switzerland.

Mantanus, J., Ziemons, E., Streel, B., Klinkenberg, R., Evrard, B., Hubert, P., & Rantanen, J. (August 2009). Quantitative in-line monitoring of pharmaceutical pellets active content using near infrared spectroscopy. Poster session presented at 3rd Annual Pharmaceutical Solid State Research Cluster Symposium, Copenhagen, Denmark.

Rozet, E., & Hubert, P. (2009). Rapport annuel du projet "Prédiction des risques associés aux résultats générés par les méthodes analytiques au cours des étapes de leur cycle de vie.". (1).

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Govaerts, B., Olsen, B. A., Rozet, E., Boulanger, B., & Hubert, P. (30 June 2009). A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture. Talanta, 79, 77-85. doi:10.1016/j.talanta.2009.03.009
Peer Reviewed verified by ORBi

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (09 June 2009). Betamethasone in cyclodextrin in deformable liposomes for dermal applications: ex vivo diffusion studies. Paper presented at PharmSciFair, Nice, France.

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (07 June 2009). Betamethasone in cyclodextrin in deformable liposomes for dermal applications: ex vivo diffusion studies. Poster session presented at PharmSciFair, Nice, France.

Mantanus, J., Ziemons, E., Streel, B., Klinkenberg, R., Evrard, B., Hubert, P., & Rantanen, J. (June 2009). Interfacing near infrared (NIR) spectroscopy with production line - Role of sample movement and density. Poster session presented at Premier European Platform for Advancing Pharmaceutical Sciences, Nice, France.

Marini Djang'Eing'A, R., & Hubert, P. (2009). Contribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM). (Rapport semestre 1). Liège, Belgium: ULg.

Hubert, C., Houari, S., Houbart, V., De Bleye, C., Fillet, M., Rozet, E., & Hubert, P. (June 2009). Development and validation of a sensitive SPE/LC/MS method for the determination of glucosamine in dog plasma. Poster session presented at 34th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Dresden, Germany.

Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2009). Rapport d'activités scientifiques du Projet ETI-QC N°716607. (Rapport N°3). Liège, Belgium: ULg.

Ziemons, E., Rozet, E., & Hubert, P. (2009). Développement d'une méthodologie statistique basée sur l'intervalle de tolérance pour la sélection et l'évaluation de modèles robustes dans le domaine de la spectroscopie et de l'imagerie proche infrarouge. (1er semestre).

Gillet, A., Grammenos, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (14 May 2009). Betamethasone in cyclodextrin in deformable liposomes for cutaneous applications: development and diffusion studies. Paper presented at Quatorzième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Nistor, I., Debrus, B., Lebrun, P., Rozet, E., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (27 April 2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l'analyse de mélanges de composés inconnus. Paper presented at Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium.

Ziemons, E., Ceccato, A., & Hubert, P. (2009). Utilisation de la spectroscopie proche infrarouge dans la cadre de la fabrication d'un dispositif intra-utérin. (2ème semestre).

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (01 April 2009). Betamethasone in cyclodextrin in deformable liposomes for topical applications: absorption studies using pig skin. Poster session presented at Biomedica, Liège, Belgium.

Hubert, C., Ziemons, E., & Hubert, P. (2009). Développement et validation d'une méthode de dosage de la glucosamine dans le plasma cannin par SPE/LC/MS.

Mantanus, J., Ziemons, E., & Hubert, P. (2009). Etablissement d'interfaces proche infrarouge adaptées à la nature du mouvement des pellets pharmaceutiques. (1).

Gillet, A., Lecomte, F., Rozet, E., Hubert, P., Evrard, B., & Piel, G. (09 March 2009). development and validation of a SPE-LC-UV method for the determination of betamethasone in pig skin. Poster session presented at Skin and Formulation 3rd Symposium and Skin Forum 10th Annual Meeting, Versailles, France.

Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2009). Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: method development and validation. Analytica Chimica Acta, 642 (1-2), 186-92. doi:10.1016/j.aca.2008.12.031
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Rozet, E., Nistor, I., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l’analyse de mélanges de composés inconnus. Spectra Analyse, 268, 28-33.
Peer reviewed

Rozet, E., Bouabidi, A., Bouklouze, A., Talbi, M., Boulanger, B., & Hubert, P. (2009). Analysis of several analytical method validation strategies. Poster session presented at 21st International Symposium on Pharmaceutical and Biomedical Analysis.

Bimazubute, M., Rozet, E., Van Heugen, J.-C., Hubert, P., Gustin, P., & Chiap, P. (2009). Dosage d'oxytétracycline dans les secrétions nasales de porcs par chromatographie liquide : comparaison d'associations de méthodes de préparations d'échantillons et de modes de détection. Poster session presented at 8e cognrès francophone de l'AFSEP sur les sciences séparatives et couplages, Marseille, France.

Boulanger, B., Moonen, F., & Hubert, P. (2009). Validation for analytical methods : reducing the risk of decisions. Tutorial 04. Paper presented at 34th international symposium on high performance liquid phase separation and related techniques, Dresden, Germany.

Rozet, E., Dewe, W., & Hubert, P. (2009). Gestion des risques lors du transfert de méthodes analytiques.

Boulanger, B., & Hubert, P. (2009). Short Course on Methof Validation. Paper presented at 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Dresden, Germany.

Rozet, E., Fillet, M., Bouabidi, A., Ziemons, E., Talbi, M., Bouklouze, A., Boulanger, B., & Hubert, P. (2009). Critical analysis of several analytical method validation strategies in the framework of the fit for purpose concept. Poster session presented at HPLC.

Rozet, E., Boulanger, B., Marini Djang'Eing'A, R., Ziemons, E., Rudaz, S., & Hubert, P. (2009). Validation of bioanalytical methods using total error. Paper presented at 21st International Symposium on Pharmaceutical and Biomedical Analysis.

Rozet, E., Boulanger, B., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2009). Total Error for the validation of bioanalytical methods. Paper presented at TIAFT - The International Association of Forensic Toxicologists.

Rozet, E., Dewe, W., Boulanger, B., & Hubert, P. (2009). Total Error-Based Criterion for Analytical Method Transfer. Poster session presented at 21st International Symposium on Pharmaceutical and Biomedical Analysis.

Rozet, E., Boulanger, B., Rudaz S, Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2009). Total Error for the Valildation of Bioanalytical methods. Annales de Toxicologie Analytique, 21 (S1), 35.
Peer Reviewed verified by ORBi

Rozet, E., Boulanger, B., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2009). Universal applicability of Total Error for the validation of bioanalytical methods. Paper presented at 4èmes JOURNEES INTERNATIONALES de toxicologie, liege, Belgium.

Rozet, E., Mantanus, J., Ziemons, E., Boulanger, B., Dewe, W., Crommen, J., & Hubert, P. (2009). Practical Implementation of Total Error for the Validation of Chromatographic and Ligand Binding Assays. Paper presented at PharmSciFair.

Boemer, F., Bours, V., Schoos, R., Hubert, P., & Rozet, E. (2009). Analytical validation based on total error measurement and cut-off interpretation of a neonatal screening TSH-immunoassay. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877, 2412-2417. doi:10.1016/j.jchromb.2008.11.004
Peer Reviewed verified by ORBi

Rozet, E., Dewé, W., Ziemons, E., Bouklouze, A., Boulanger, B., & Hubert, P. (2009). Methodologies for the transfer of analytical methods: A review. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877, 2214-2223. doi:10.1016/j.jchromb.2008.12.049
Peer Reviewed verified by ORBi

Rozet, E., Rudaz, S., Bouabidi, A., Talbi, M., Bouklouze, A., Boulanger, B., & Hubert, P. (2009). Evaluation of decision methodologies for analytical method validation. Poster session presented at RDPA - 13th international meeting on recent development in pharmaceutical analysis.

Rudaz, S., & Hubert, P. (Eds.). (2009). Method validation, comparison and transfer. Kidlington OX5 1GB, United Kingdom: Elsevier. doi:10.1016/j.jchromb.2009.06.018

Martin, G., Mansion, F., Servais, A.-C., Debrus, B., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2009). CE-MS method development for peptides analysis, especially hepcidin, an iron metabolism marker. Electrophoresis, 30 (15), 2624-31. doi:10.1002/elps.200800794
Peer Reviewed verified by ORBi

Ziemons, E., & Hubert, P. (2009). Good Laboratory Practice: How to avoid pitfalls of quantitative analysis. (ULiège - Université de Liège).

Rafamantanana, M. H., Rozet, E., Raoelison, G. E., Cheuk, K., Ratsimamanga, S. U., Hubert, P., & Quetin-Leclercq, J. (2009). An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE). Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (23), 2396-402. doi:10.1016/j.jchromb.2009.03.018
Peer Reviewed verified by ORBi

Boulanger, B., Rozet, E., Moonen, F., Rudaz, S., & Hubert, P. (2009). A risk-based analysis of the AAPS conference report on quantitative bioanalytical methods validation and implementation. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (23), 2235-43. doi:10.1016/j.jchromb.2009.06.019
Peer Reviewed verified by ORBi

Hubert, P. (2008). Les techniques analytiques vertes au secours de la santé publique. (Le Pharmacien, N° 30, 8 décembre 2008). Bruxelles, Belgium: Roularta Medica.

Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2008). Rapport d'activités scientifiques du Projet ETI-QC N°716607. (Rapport N°4 (et final)). Liège, Belgium: ULg.

Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2008). Rapport d'activités scientifiques du Projet ETI-QC N°716607. (Rapport N°2, -). Liège, Belgium: ULg.

Ziemons, E., Rozet, E., & Hubert, P. (2008). Développement d'un logiciel basé sur l'intervalle de tolérance pour l'estimation de l'incertitude. (Questionnaire d'évaluation des projets de recherche).

Ziemons, E., Rozet, E., & Hubert, P. (2008). Développement d'un logiciel basé sur l'intervalle de tolérance pour l'estimation de l'incertitude. (4eme semestre).

Ziemons, E., Ceccato, A., & Hubert, P. (2008). Utilisation de la spectroscopie proche infrarouge dans la cadre de la fabrication d'un dispositif intra-utérin. (1er semestre).

Zalfen, A., Nizet, D., Jérôme, C., Jérôme, R., frankenne, F., Foidart, J.-M., Maquet, V., Lecomte, F., Hubert, P., & Evrard, B. (November 2008). Controlled release of drugs from multi-component biomaterials. Acta Biomaterialia, 4 (6), 1788-1796. doi:10.1016/j.actbio.2008.05.021
Peer Reviewed verified by ORBi

Ziemons, E., Mantanus, J., & Hubert, P. (2008). Détermination de la teneur en eau et de principes actifs dans des formulations pharmaceutiques à base de pellets par spectroscopie dans le proche infrarouge. (2).

Ziemons, E., Bourichi, H., Mantanus, J., Lebrun, P., Bouklouze, A., Cherrah, Y., & Hubert, P. (October 2008). Analyse quantitative de mélanges binaires de deux formes cristallines du fluconazole par la spectroscopie proche infrarouge et par diffraction des rayons X: comparaison des deux méthodes. Paper presented at 2ème Congrès des Sciences Analytiques, Casablanca, Morocco.

Hubert, P., Habyalimana, V., Marini Djang'Eing'A, R., & Ziemons, E. (2008). Préparation des échantillons pharmaceutiques. (ULiège - Université de Liège, PHAR0713-A-a).

Lebrun, P., Boulanger, B., Jullion, A., Govaerts, B., Debrus, B., & Hubert, P. (September 2008). Design Space for analytical methods. A Bayesian perspective based on multivariate models and prediction. Paper presented at Non-clinical statistics 2008 (NCS2008), Leuven, Belgium.

Mbinze Kindenge, J., Marini Djang'Eing'A, R., Lecomte, F., & Hubert, P. (2008). Qualification de l'appareillage. (ULiège - Université de Liège, PHAR0713-A-a).

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Rupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (July 2008). Chromatographic separation of a pharmaceutical formulation using Design of Experiment and Design Space. Poster session presented at 11th conference on Chemometrics in Analytical Chemistry (CAC'2008), Montpellier, France.

Lebrun, P., Boulanger, B., Debrus, B., Govaerts, B., & Hubert, P. (June 2008). The Expected Design Space for analytical methods: a new perspective based on modeling and prediction. Paper presented at International symposium on biopharmaceutical statistics, Shanghai, China.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Jupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (June 2008). Usefulness of design space for the optimization of chromatographic separations. Paper presented at 19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2008), Gdansk, Poland.

Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2008). Rapport d'activités scientifiques du Projet ETI-QC N°716607. (Rapport N°1, -). Liège, Belgium: ULg.

Ziemons, E., Rozet, E., & Hubert, P. (2008). Développement d'un logiciel basé sur l'intervalle de tolérance pour l'estimation de l'incertitude. (3eme semestre).

Lebrun, P., Debrus, B., Boulanger, B., Govaerts, B., & Hubert, P. (May 2008). Use of Independent Component Analysis and clustering methods to find and identify relevant components in a matrix of UV-spectral data.

Hubert, P. (2008). Relations interuniversitaires : Situation et perspectives. Paper presented at Remise d'une distinction, Cluj – Napoca, Romania.

Ziemons, E., Mantanus, J., & Hubert, P. (2008). Détermination de la teneur en eau et de principes actifs dans des formulations pharmaceutiques à base de pellets par spectroscopie dans le proche infrarouge. (1).

Kpoviessi, D. S. S., Gbaguidi, F., Gbenou, J., Accrombessi, G., Moudachirou, M., Rozet, E., Hubert, P., & Quetin-Leclercq, J. (2008). Validation of a method for the determination of sterols and triterpenes in the aerial part of Justicia anselliana (Nees) T. Anders by capillary gas chromatography. Journal of Pharmaceutical and Biomedical Analysis, 48 (4), 1127-35. doi:10.1016/j.jpba.2008.08.036
Peer Reviewed verified by ORBi

Bimazubute, M. A., Rozet, E., Dizier, I., Gustin, P., Hubert, P., Crommen, J., & Chiap, P. (2008). Liquid chromatographic determination of enrofloxacin in nasal secretions and plasma of healthy pigs using restricted access material for on-line sample clean-up. Journal of Chromatography. A, 1189 (1-2), 456-466. doi:10.1016/j.chroma.2007.11.011
Peer Reviewed verified by ORBi

Rozet, E., & Hubert, P. (2008). Short Course on Method Validation. Paper presented at 19th international symposium on pharmaceutical and biomedical analysis.

Rozet, E., Dewe, W., Boulanger, B., Ziemons, E., Hubert, C., Moonen, F., & Hubert, P. (2008). Simultaneous improvement of the predictive character of the validation data and estimation of measurement uncertainty. Paper presented at Agrostat, Louvain-la-Neuve, Belgium.

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., Valat, L., & Rozet, E. (2008). Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal part IV. Examples of application. Journal of Pharmaceutical and Biomedical Analysis, 48 (3), 760-71. doi:10.1016/j.jpba.2008.07.018
Peer Reviewed verified by ORBi

Bouabidi, A., Talbi, M., Bouklouze, A., Rozet, E., & Hubert, P. (2008). COMPARAISON DES STRATEGIES DE VALIDATION DE METHODES ANALYTIQUES SFSTP 1992 et SFSTP 2003; ETUDE DE L’EFFET DE LOT SUR LA VALIDATION ANALYTIQUE : CAS DU DOSAGE D’UN PA DANS LE PRODUIT FINI PAR ABSORBANCE. Poster session presented at Congrès des Sciences Analytiques.

Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2008). Determination of moisture content in pharmaceutical pellets using near infrared spectroscopy: Method development and validation. Paper presented at PAT Workshop, Gent, Belgium.

Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., & Hubert, P. (2008). Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: model selection, evaluation and validation. Poster session presented at 11th Conference on Chemometrics in Analytical Chemistry, Montpellier, France.

Ziemons, E., Lejeune, R., & Hubert, P. (2008). Supports visuels réalisés dans le cadre des travaux pratiques de Chimie Analytique (Partie II). (ULiège - Université de Liège, CHIM0321-2 - Travaux pratiques - Introduction à la Chimie Analytique).

Cavalier, E., Rozet, E., Dubois, N., Charlier, C., Hubert, P., Chapelle, J.-P., Krzesinski, J.-M., & Delanaye, P. (2008). Performance of iohexol determination in serum and urine by HPLC: validation, risk and uncertainty assessment. Clinica Chimica Acta, 396, 80-85. doi:10.1016/j.cca.2008.07.011
Peer Reviewed verified by ORBi

Rozet, E., Dewé, W., Morello, R., Chiap, P., Lecomte, F., Ziemons, E., Boos, K. S., Boulanger, B., Crommen, J., & Hubert, P. (2008). Risk-Based Approach for the Transfer of Quantitative Methods: Bioanalytical Applications. Journal of Chromatography. A, 1189, 32-41. doi:10.1016/j.chroma.2007.11.029
Peer Reviewed verified by ORBi

Ziemons, E., Mantanus, J., Lebrun, P., Rozet, E., & Hubert, P. (2008). Reflexions, La Chimie Analytique Verte. (Planet'ULg, ULiège - Université de Liège). Reflexions.

Ziemons, E., Mantanus, J., & Hubert, P. (2008). PlanetULg, La Chimie Analytique Verte. (ULiège - Université de Liège).

Lebrun, P., Govaerts, B., Debrus, B., Ceccato, A., Caliaro, G., Hubert, P., & Boulanger, B. (2008). Development of a new predictive modelling technique to find with confidence equivalence zone and design space of chromatographic analytical methods. Chemometrics and Intelligent Laboratory Systems, 91, 4-16. doi:10.1016/j.chemolab.2007.05.010
Peer Reviewed verified by ORBi

Ziemons, E., Rozet, E., & Hubert, P. (2007). Développement d'un logiciel basé sur l'intervalle de tolérance pour l'estimation de l'incertitude. (2ème semestre).

Dalmi, M., Hubert, C., Breuer, A., & Hubert, P. (November 2007). Spéciation et dosage de Sn(IV) dans un catalyseur, l'octanoate d'étain (II). Etude de deux paramètres importants du processus analytique. Poster session presented at JSNES 2007, Mohammedia, Morocco.

Bodson, C., Rozet, E., Ziemons, E., Evrard, B., Hubert, P., & Delattre, L. (18 October 2007). Validation of manufacturing process of Diltiazem HCl tablets by NIR spectrophotometry (NIRS). Journal of Pharmaceutical and Biomedical Analysis, 45 (2), 356-361. doi:10.1016/j.jpba.2007.05.015
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., Valat, L., & Rozet, E. (21 September 2007). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - Part II. Journal of Pharmaceutical and Biomedical Analysis, 45 (1), 70-81. doi:10.1016/j.jpba.2007.06.013
Peer Reviewed verified by ORBi

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Chapuis-Hugon, F., Chiap, P., Crommen, J., Luxen, A., Pichon, V., & Hubert, P. (September 2007). PPERFORMANCE EVALUATION OF TWO MIPS FOR THE SPE-LC-UV DETERMINATION OF p-[18F]MPPF IN PLASMA. Poster session presented at RDPA 2007, 12th Internatioinal Meeting on Recent Developments in Pharmaceutical Analysis, Island of Elba, Italy.

Rozet, E., Hubert, C., Ceccato, A., Dewé, W., Ziemons, E., Moonen, F., Michail, K., Wintersteiger, R., Streel, B., Boulanger, B., & Hubert, P. (27 July 2007). Using tolerance intervals in pre-study validation of analytical methods to predict in-study results - The fit-for-future-purpose concept. Journal of Chromatography. A, 1158 (1-2), 126-137. doi:10.1016/j.chroma.2007.03.102
Peer Reviewed verified by ORBi

Rozet, E., & Hubert, P. (2007). Rapport final de la prolongation du Programme FIRST EUROPE Convention n° EPH3310300R0222 / 215269 Projet TRANSVAL.

Hubert, C., streel, B., Sibenaler, R., Chiap, P., & Hubert, P. (July 2007). Development and pre-validation of a high sensitive method for the determination of levonorgestrel in human plasma by SPE/LC/MS-MS. Poster session presented at 31th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Gand, Belgium.

Wascotte, V., Delgado-Charro, B., Rozet, E., Wallemacq, P., Hubert, P., Guy, R. H., & Préat, V. (June 2007). Monitoring of urea and potassium by reverse iontophoresis in vitro. Pharmaceutical Research, 24 (6), 1131-1137. doi:10.1007/s11095-007-9237-0
Peer Reviewed verified by ORBi

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Denjean, C., Chapuis-Hugon, F., Chiap, P., Crommen, J., Luxen, A., Pichon, V., & Hubert, P. (June 2007). DEVELOPMENT AND VALIDATION OF A METHOD FOR THE LC DETERMINATION p-[18F]MPPF IN PLASMA USING A MISPE. Poster session presented at HPLC 2007 - 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Ghent, Belgium.

Marini Djang'Eing'A, R., Servais, A.-C., Rozet, E., Chiap, P., Boulanger, B., Rudaz, S., Crommen, J., Hubert, P., & Fillet, M. (June 2007). Enantiomeric purity testing of S-timolol by non-aqueous CE using heptakis(2,3-di-O-methyl-6-O-Sulfo)-β-cyclodextrin as chiral additive – Validation using the accuracy profile strategy and estimation of uncertainty. Poster session presented at 31st International Symposium on HPLC and Related techniques, Gand, Belgium.

Lebrun, P., Debrus, B., Boulanger, B., Caliaro, G., Ceccato, A., & Hubert, P. (June 2007). Numerical separation in HPLC-UV-DAD with Independent Component Analysis (ICA) using high order statistics for the automated identification of peaks. Poster session presented at HPLC 2007, Gent, Belgium.

Ziemons, E., Rozet, E., & Hubert, P. (2007). Développement d'un logiciel basé sur l'intervalle de tolérance pour l'estimation de l'incertitude. (1 semestre).

Rozet, E., Wascotte, V., Lecouturier, N., Préat, V., Dewé, W., Boulanger, B., & Hubert, P. (May 2007). Improvement of the decision efficiency of the accuracy profile by means of a desirability function for analytical methods validation - Application to a diacetyl-monoxime colorimetric assay used for the determination of urea in transdermal iontophoretic extracts. Analytica Chimica Acta, 591 (2), 239-247. doi:10.1016/j.aca.2007.04.002
Peer Reviewed verified by ORBi

Ziemons, E., Mbakop, N. W., Rozet, E., Lejeune, R., Angenot, L., Thunus, L., & Hubert, P. (April 2007). Optimisation of SFE method on-line coupled to FT-IR spectroscopy for the real-time monitoring of the extraction of tagitinin C in T-diversifolia. Journal of Supercritical Fluids, 40 (3), 368-375. doi:10.1016/j.supflu.2006.07.009
Peer Reviewed verified by ORBi

Ziemons, E., Rozet, E., Lejeune, R., Angenot, L., & Hubert, P. (20 March 2007). Dosage en ligne d'une molécule d'origine naturelle dans le CO2 supercritique à l'aide d'une cellule à haute pression équipée de fibres optiques couplant un spectrophotomère IRTF à un extracteur à fluide supercritique. Poster session presented at SEP 2007, Grenoble, France.

Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Séparation numérique et quantification automatique de pics en CLHP-UV grâce à l’utilisation de l’analyse en composantes indépendantes (ICA). Paper presented at SEP 2007, Grenoble, France.

Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Evaluation d'une nouvelle méthode pour le développement entièrement automatisé de méthodes analytiques en chromatographie liquide. Poster session presented at SEP 2007, Grenoble, France.

Hubert, P., & NGUYEN-HUU, J. J. (12 March 2007). validation des procédures analytiques quantitatives. Harmonisation des démarches. Session d'étude présentée par les membres de la commission. Paper presented at SFSTP, Paris, France.

Hubert, C., Rozet, E., Ceccato, A., Dewé, W., Ziemons, E., Moonen, F., Michail, K., Wintersteiger, R., Streel, B., Boulanger, B., & Hubert, P. (March 2007). Validation versus routine : Evaluation de l'aspect prédictif de l'intervalle de tolérance. Poster session presented at 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Grenoble, France.

Ziemons, E., Barillaro, V., Rozet, E., Mbakop, N. W., Lejeune, R., Angenot, L., Thunus, L., & Hubert, P. (15 February 2007). Direct determination of tagitinin C in Tithonia diversifolia leaves by on-line coupling of supercritical carbon dioxide extraction to FT-IR spectroscopy by means of optical fibres. Talanta, 71 (2), 911-917. doi:10.1016/j.talanta.2006.05.076
Peer Reviewed verified by ORBi

Dewé, W., Govaerts, B., Boulanger, B., Rozet, E., Chiap, P., & Hubert, P. (15 February 2007). Using total error as decision criterion in analytical method transfer. Chemometrics and Intelligent Laboratory Systems, 85 (2), 262-268. doi:10.1016/j.chemolab.2006.07.003
Peer Reviewed verified by ORBi

Ziemons, E., Dive, G., Debrus, B., Barillaro, V., Frederich, M., Lejeune, R., Angenot, L., Delattre, L., Thunus, L., & Hubert, P. (February 2007). Study of the physicochemical properties in aqueous medium and molecular modeling of tagitinin C/cyclodextrin complexes. Journal of Pharmaceutical and Biomedical Analysis, 43 (3), 910-919. doi:10.1016/j.jpba.2006.09.011
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J. J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., Valat, L., & Rozet, E. (2007). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - Part III. Journal of Pharmaceutical and Biomedical Analysis, 45 (1), 82-96. doi:10.1016/j.jpba.2007.06.032
Peer Reviewed verified by ORBi

Rudaz, S., & Hubert, P. (2007). Short Course on Validation. Paper presented at 12th International Meeting on Recent Developments in Pharmaceutical Analysis (RDPA 2007), Isola d'Elba, Italy.

Boulanger, B., Dewé, W., Hubert, P., & Moonen, F. (2007). Statistical considerations for the validation of an ELISA assay as biomarker. Paper presented at Bioassays in clinical development, Londres, United Kingdom.

Oprean, R., Rozet, E., Dewé, W., Boulanger, B., & Hubert, P. (2007). Guide for validation of analytical procedures. Cluj-Napoca, Romania: Medicala Universitara “Iuliu Hatieganu”.

Lecomte, F., Aerts, J., Houbart, V., Plenevaux, A., Lignon, S., Chiap, P., Crommen, J., Luxen, A., Pichon, V., & Hubert, P. (2007). EVALUATION DE DEUX POLYMERES A EMPREINTES MOLECULAIRES POUR LE DOSAGE DU p-[18F]MPPF DANS LE PLASMA. Poster session presented at 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages - SEP07, Grenoble, France.

Rozet, E., Dewe, W., Boulanger, B., & Hubert, P. (2007). Total Error-Based Criterion for Analytical Method Transfer Experiments. Paper presented at AMSTAT Joint Statistical Meeting.

Mansion, F., Chen, F., Martin, G., Servais, A.-C., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2007). Study of the influence of the peak focusing effect in capillary LC columns on detection sensitivity - application to the determination of low concentrations of hepcidine in biofluids. Poster session presented at 31st international symposium on high performance liquid phase separations and related techniques, Gand, Belgium.

Boulanger, B., Dewé, W., Moonen, F., & Hubert, P. (2007). Prediction-based decision for validation of (bio)analytical methods using tolerance intervals and accuracy profiles.

Rozet, E., Dewe, W., Govaerts, B., Boulanger, B., Ceccato, A., Chiap, P., Crommen, J., & Hubert, P. (2007). Evaluation of Analytical Method Transfer on a Risk Based Methodology using Total Error. Paper presented at HPLC.

Boulanger, B., & Hubert, P. (2007). Short Course on Method validation. Paper presented at 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Gand, Belgium.

Rozet, E., Dewe, W., Boulanger, B., Ziemons, E., Marini Djang'Eing'A, R., Moonen, F., & Hubert, P. (2007). LA PREDICTION DES RISQUES ASSOCIES AUX DONNEES DU CYCLE DE VIE DES METHODES DE DOSAGE. Paper presented at VI Colloquium Chemometricum Mediterraneum.

Rozet, E., Dewe, W., Morello, R., Chiap, P., Ziemons, E., Boos, K. S., Boulanger, B., & Hubert, P. (2007). GESTION DU RISQUE LORS DU TRANSFERT DE METHODES ANALYTIQUES – CAS D’UNE METHODE BIOANALYTIQUE. Paper presented at SEP07.

Boulanger, B., Dewé, W., Moonen, F., & Hubert, P. (2007). Prediction-based decision for validation of (bio)analytical methods using tolerance intervals and accuracy profiles. Paper presented at Joint Statistical Meeting, Salt Lake City, United States.

Ziemons, E., & Hubert, P. (2007). La spectroscopie infrarouge (Mid-IR & NIR). (ULiège - Université de Liège, CHIM0330-1 - Chimie Analytique (Partim I)).

Rozet, E., & Hubert, P. (2007). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°7. (7).

Rozet, E., Ceccato, A., Hubert, C., Ziemons, E., Oprean, R., Rudaz, S., Boulanger, B., & Hubert, P. (2007). Analysis of recent pharmaceutical regulatory documents on analytical method validation. Journal of Chromatography. A, 1158 (1-2), 111-25. doi:10.1016/j.chroma.2007.03.111
Peer Reviewed verified by ORBi

Rozet, E., Dewe, W., Govaerts, B., Boulanger, B., Moonen, F., Crommen, J., & Hubert, P. (2007). PAT COMPLIENT APPROACHES TO ASSESS THE ACCEPTABILITY OF ANALYTICAL METHOD TRANSFER: HOW TO LIMIT THE RISK TO OBTAIN OOS RESULTS? Poster session presented at RDPA - 12th international meeting on Recent Development in Pharmaceutical Analysis.

Martin, G., Chiap, P., Paquet, P., Pierard, G., De Tullio, P., Martin, Y., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2007). Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up. Journal of Chromatography. A, 1156 (1-2), 141-8. doi:10.1016/j.chroma.2006.12.088
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Rozet, E., Vanderheyden, Y., Ziemons, E., Boulanger, B., Bouklouze, A., Servais, A.-C., Fillet, M., Crommen, J., & Hubert, P. (2007). Robustness testing of a chiral NACE method for R-timolol determination in S-timolol maleate and uncertainty assessment from quantitative data. Journal of Pharmaceutical and Biomedical Analysis, 44 (3), 640-51. doi:10.1016/j.jpba.2006.08.018
Peer Reviewed verified by ORBi

Rozet, E., Dewe, W., Boulanger, B., Ziemons, E., Hubert, C., Marini Djang'Eing'A, R., Moonen, F., & Hubert, P. (2007). PREDICTION OF THE RISKS LINKED TO THE DATA GENERATED DURING THE LIFE CYCLE OF QUANTITATIVE ANALYTICAL METHODS. Paper presented at 13eme Forum des Sciences Pharmaceutiques, Spa, Belgium.

Ziemons, E., Houbart, V., Lejeune, R., & Hubert, P. (2007). Supports visuels réalisés dans le cadre des travaux pratiques de Chimie Analytique (Partie I). (ULiège - Université de Liège, CHIM0321-2 - Travaux pratiques - Introduction à la Chimie Analytique).

Ziemons, E., & Hubert, P. (2007). L'extraction de matrices solides. (ULiège - Université de Liège, CHIM0331-1 - Chimie Analytique (Partim II)).

Rozet, E., Morello, R., Lecomte, F., Martin, G. B., Chiap, P., Crommen, J., Boos, K.-S., & Hubert, P. (05 December 2006). Performances of a multidimensional on-line SPE-LC-ECD method for the determination of three major catecholamines in native human urine: Validation, risk and uncertainty assessments. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 844 (2), 251-260. doi:10.1016/j.jchromb.2006.07.060
Peer Reviewed verified by ORBi

Hubert, C., Ziemons, E., & Hubert, P. (2006). Val06-004 - Validation du dosage du LNG contenu dans les réservoirs du Levosert-20.

Boulanger, B., Dewé, W., Ceccato, A., Debrus, B., Lebrun, P., & Hubert, P. (December 2006). Utilisation de l’Analyse en Composantes Indépendantes (ICA) pour la séparation numérique des pics et la quantification automatique en CLHP-UV. Paper presented at Chimiométrie 2006, Paris, France.

Lebrun, P., Boulanger, B., Hubert, P., Debrus, B., & Govaerts, B. (December 2006). Statistical Models and Multi-Criteria Optimization Techniques in Chromatography. Paper presented at Chimiométrie 2006, Paris, France.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (November 2006). Comparaison de trois approches pour l'estimation de l'incertitude. Paper presented at 3ème journée internationale de toxicologie hospitalière, Liège, Belgium.

Hubert, P., Rozet, E., Crommen, J., Dewé, W., & Boulanger, B. (28 September 2006). développement récent dans le domaine de la validation des méthodes analytiques. Paper presented at 13e Congrès National de Pharmacie, Cluj-Napoca, Romania.

Rozet, E., Mertens, B., Dewé, W., Ceccato, A., Govaerts, B., Boulanger, B., Chiap, P., Streel, B., Crommen, J., & Hubert, P. (11 September 2006). The transfer of a LC-UV method for the determination of fenofibrate and fenofibric acid in Lidoses: Use of total error as decision criterion. Journal of Pharmaceutical and Biomedical Analysis, 42 (1), 64-70. doi:10.1016/j.jpba.2005.12.037
Peer Reviewed verified by ORBi

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Haber, G., Boulanger, B., Chiap, P., Luxen, A., & Hubert, P. (September 2006). EVALUATION OF MOLECULARLY IMPRINTED POLYMERS BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF p-[18F]MPPF IN PLASMA. Poster session presented at MIP2006 - Fourth International Workshop on Molecularly Imprinted Polymers, Cardiff, United Kingdom.

Rozet, E., & Hubert, P. (2006). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°6. (5).

Bodson, C., Dewé, W., Hubert, P., & Delattre, L. (07 June 2006). Comparison of FT-NIR transmission and UV-vis spectrophotometry to follow the mixing kinetics and to assay low-dose tablets containing riboflavin. Journal of Pharmaceutical and Biomedical Analysis, 41 (3), 783-790. doi:10.1016/j.jpba.2006.01.022
Peer Reviewed verified by ORBi

Rozet, E., Dewe, W., Boulanger, B., & Hubert, P. (11 May 2006). Comparaison de différentes approches pour accepter un transfert de méthodes analytiques. Paper presented at Club Lyonnais de Chromatographie, Lyon, France.

Marini Djang'Eing'A, R., Rozet, E., Ziemons, E., Chiap, P., Boulanger, B., Rudaz, S., Servais, A.-C., Fillet, M., Crommen, J., & Hubert, P. (May 2006). COMPARISON OF THREE DIFFERENT APPROACHES FOR UNCERTAINTY ESTIMATION CONSIDERING LC AND CE METHODS. Paper presented at A joint meeting of two distinguished series: the 8th International Symposium on Drug Analysis and the 17th International Symposium on Pharmaceutical and Biomedical Analysis, Namur, Belgium.

Hubert, C., Lambert, A., Ziemons, E., Hubert, P., & Lejeune, R. (May 2006). Speciation analysis of Sn(II) and Sn(IV) in stannous octoate using differential pulse polarography. Poster session presented at Drug Analysis 2006, Namur, Belgium.

Hubert, C., Rozet, E., Boulanger, B., Dewé, W., Breuer, A., Collard, L., Evrard, B., & Hubert, P. (May 2006). Validation of a LC method for the determination of levonorgestrel released from a polymeric matrix. A two days protocol. Poster session presented at Drug Analysis 2006, Namur, Belgium.

Esters, V., Angenot, L., Brandt, V., Frederich, M., Tits, M., Van Nerum, C., Wauters, J.-N., & Hubert, P. (21 April 2006). Validation of a high-performance thin-layer chromatography/densitometry method for the quantitative determination of glucosamine in a herbal dietary supplement. Journal of Chromatography. A, 1112 (1-2), 156-164. doi:10.1016/j.chroma.2006.01.035
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., & Valat, L. (April 2006). Validation des procédures analytiques quantitatives :harmonisation des démarches - Partie III. Exemples d’application. STP Pharma Pratiques, 16 (2), 87-121.
Peer reviewed

Lecomte, F., Boulanger, B., Hall, A. J., Sellergren, B., Crommen, J., Chiap, P., & Hubert, P. (March 2006). Développement d’une méthode de dosage automatisé du méthotrexate dans le plasma humain par couplage direct à la chromatographie liquide de l’extraction sur phase solide à empreintes moléculaires. Poster session presented at Forum LABO & Forum BIOTECH 2006, Paris, France.

Marini Djang'Eing'A, R., Groom, C., Doucet, F. R., Hawari, J., Bitar, Y., Holzgrabe, U., Gotti, R., Schappler, J., Rudaz, S., Veuthey, J.-L., Mol, R., Somsen, G. W., de Jong, G. J., Ha, P. T. T., Zhang, J., Van Schepdael, A., Hoogmartens, J., Brione, W., Ceccato, A., & Hubert, P. (2006). Interlaboratory study of a NACE method for the determination of R-timolol content in S-timolol maleate: assessment of uncertainty. Electrophoresis, 27 (12), 2386-99. doi:10.1002/elps.200500832
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (2006). Comparaison de trois approches pour l'estimation de l'incertitude. Acta Clinica Belgica. Supplementum, (1), 60-2.
Peer Reviewed verified by ORBi

Rachidi, M., Cherra, Y., Digua, K., Hubert, P., & Bouklouze, A. (2006). Validation of a potentiometric method using azithromycin selective electrode. Poster session presented at Drug Analysis, Namur, Belgium.

Do Thi, T., Pomponi, R., Gotti, R., Saevels, J., Van Hove, B., Van Ael, W., Matthijs, N., Vander Heyden, Y., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., Fabre, H., Dehouck, P., Hoogmartens, J., & Van Schepdael, A. (2006). Precision study on capillary electrophoresis methods for metacycline. Electrophoresis, 27 (12), 2317-2329. doi:10.1002/elps.200500873
Peer Reviewed verified by ORBi

Rozet, E., Boulanger, B., Dewe, W., Chiap, P., Moonen, F., Govaerts, B., Crommen, J., & Hubert, P. (2006). GERER LE RISQUE LORS DE LA VALIDATION DES METHODES ANALYTIQUES : APPLICATION A LA DETERMINATION D’IMPURETES. Paper presented at Congrès des Sciences Analytiques, Marrakech, Morocco.

Marini Djang'Eing'A, R.* , Servais, A.-C.* , Rozet, E., Chiap, P., Boulanger, B., Rudaz, S., Crommen, J., Hubert, P., & Fillet, M. (2006). Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty. Journal of Chromatography. A, 1120 (1-2), 102-11. doi:10.1016/j.chroma.2006.03.104
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (2006). LC method for the determination of R-timolol in S-timolol maleate: Validation of its ability to quantify and uncertainty assessment. Talanta, 68 (4), 1166-1175. doi:10.1016/j.talanta.2005.07.026
Peer Reviewed verified by ORBi

Rozet, E., Dewé, W., Chiap, P., Lecomte, F., & Hubert, P. (2006). Le transfert d'une methode de dosage automatisee de la noradrenaline dans l'urine humaine: utilisation de l'erreur totale comme critere de decision. Acta Clinica Belgica. Supplementum, (1), 57-9.
Peer Reviewed verified by ORBi

Rachidi, M., Digua, K., Hubert, P., Faouzi, M. A., Cherrah, Y., & Bouklouze, A. (2006). Analytical validation of potentiometric method for cetirizinium ion. Analytical Letters, 39 (8), 1699-1708. doi:10.1080/00032710600713925
Peer Reviewed verified by ORBi

Martin, G., Chiap, P., Paquet, P., Pierard, G., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2006). Determination of a melanoma biomarker in human plasma the 5-S-cysteinyl-l-dopa by LC-ESI-MS-MS. Paper presented at 30rd international symposium on high performance liquid phase separation and related techniques, San Francisco, United States.

Martin, G., Chiap, P., Paquet, P., Pierard, G., Hubert, P., Crommen, J., & Fillet, M. (2006). Determination of catecholamines in human plasma using solid phase extraction and LC-ESI-MS-MS. Poster session presented at Drug Analysis, Namur, Belgium.

Martin, G., Chiap, P., Pierard, G., Hubert, P., Crommen, J., & Fillet, M. (2006). LC-ESI-MS-MS determination of 5-S-L-cysteinyl-L-dopa, a melanoma biomarker, in human plasma. Poster session presented at Drug Analysis, Namur, Belgium.

Boulanger, B., Dewé, W., Hubert, P., & Govaerts, B. (2006). Conciliating objectives of analytical methods and objectives of validation : a statistical perspective. Paper presented at I.V.T, Amsterdam, Netherlands.

Feinberg, M., Laurentie, M., Hubert, P., Boulanger, B., & Dewé, W. (2006). Les laboratoires accrédités saisis par l'incertitude. Paper presented at Forum Labo, Paris, France.

Rozet, E., Dewe, W., Morello, R., Chiap, P., Boos, K. S., & Hubert, P. (2006). Transfert d’une méthode de dosage automatisée de 3 catécholamines majeures dans l’urine humaine. Poster session presented at Forum Labo.

Rozet, E., Boulanger, B., Dewe, W., Hubert, P., & Moonen, F. (2006). Applying statistics recomended by regulatory documents. Paper presented at Method Validation.

Rozet, E., Morello, R., Dewe, W., Chiap, P., Boulanger, B., Boos, K. S., Crommen, J., & Hubert, P. (2006). TRANSFER OF A MULTIDIMENSIONAL ON-LINE SPE-LC-ECD METHOD FOR THE DETERMINATION OF THREE MAJOR CATECHOLAMINES IN NATIVE HUMAN URINE. Poster session presented at HPLC.

Rozet, E., Ziemons, E., Eppe, G., Dewe, W., Boulanger, B., & Hubert, P. (2006). SIMULTANEOUS ESTIMATION OF MEASUREMENT UNCERTAINTY AND IMPLEMENTATION OF CONTROL CHART USING QUALITY CONTROL STANDARDS. Poster session presented at Drug Analysis.

Boulanger, B., Dewé, W., Hubert, P., Govaerts, B., & Hammer, C. (2006). Accuracy and precision : total error vs 4-6-30. Paper presented at 3rd bioanalytical workshop on quantitative methods validation and implementation, Crystal City, United States.

Dewé, W., Boulanger, B., Govaerts, B., Rozet, E., & Hubert, P. (2006). Approches par l'erreur totale en transfert analytique. Paper presented at Forum Labo, Paris, France.

Rozet, E., & Hubert, P. (2006). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°5. (5).

Hubert, P., Rozet, E., Boulanger, B., Dewé, W., Laurentie, M., Dubois, N., Charlier, C., & Feinberg, M. (2006). Synchronization of validation and estimation strategies of doubt associated as part of the accreditation in trial laboratories. Acta Clinica Belgica, 61 (Suppl. 1), 54-56.
Peer Reviewed verified by ORBi

Cahay, B., Rousseau, A., Klinkenberg, R., Hubert, P., & Streel, B. (2006). New validation strategy for the LC determination of ascorbic acid in sublingual tablets. Poster session presented at Drug Analysis, Namur, Belgium.

Ziemons, E., Lejeune, R., Angenot, L., Thunus, L., & Hubert, P. (2006). Etude en temps réel du processus d'extraction de la tagitinine C en fonction des caractéristiques physico-chimiques du CO2 supercritique à l'aide de fibres optiques couplant un spectrophotomètre IRTF à un extracteur à fluide supercritique. Poster session presented at Forum Labo & Forum Biotech, Paris, France.

Ziemons, E., Barillaro, V., Rozet, E., Wandij Mbakop, N., Lejeune, R., Angenot, L., Thunus, L., & Hubert, P. (2006). Use of the accuracy profile for the validation of a direct determination of tagitinin C in Tithonia diversifolia leaves by on-line coupling of supercritical CO2 extraction to FT-IR spectroscopy by means of optical fibres. Poster session presented at Drug Analysis, Namur, Belgium.

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., & Muzard, G. (January 2006). Validation des procédures analytiques quantitatives :Partie II - Statistiques. STP Pharma Pratiques, 16 (1), 28-58.
Peer reviewed

Hubert, P., Rozet, E., Boulanger, B., Dewé, W., Laurentie, M., Dubois, N., Charlier, C., & Feinberg, M. (2006). Harmonisation des strategies de validation et estimation de l'incertitude associee dans le cadre de l'accreditation des laboratoires d'essais. Acta Clinica Belgica. Supplementum, S1 (1), 53-55.
Peer Reviewed verified by ORBi

Lecomte, F., Boulanger, B., Hall, A. J., Sellergren, B., Rozet, E., Crommen, J., Chiap, P., & Hubert, P. (September 2005). OPTIMIZATION OF MOLECULARLY IMPRINTED SOLID-PHASE EXTRACTION BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF METHOTREXATE IN HUMAN PLASMA. Poster session presented at RDPA 2005 - 11th International Meeting on Recent Developments in Pharmaceutical Analysis, Rimini, Italy.

Rozet, E., & Hubert, P. (2005). Rapport final Programme FIRST EUROPE Convention n° EPH3310300R0222 / 215269 Projet TRANSVAL.

Rozet, E., & Hubert, P. (2005). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°4. (4).

bodson, C., Hubert, P., & Delattre, L. (12 June 2005). instrumentation of a high shear mixer for in-line monitoring of a pharmaceutical blending process using FT-NIR spectroscopy. Paper presented at PharmSciFair, Nice, France.

Lecomte, F., Hall, A. J., Sellegren, B., Crommen, J., Hubert, P., & Chiap, P. (June 2005). Evaluation of molecularly imprinted polymers for selective extraction of methotrexate from human plasma prior to its LC determination. Poster session presented at   HPLC 2005 - 29th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Stockholm, Sweden.

Crommen, J., Marini Djang'Eing'A, R., Servais, A.-C., Chiap, P., Rozet, E., Hubert, P., & Fillet, M. (June 2005). Validation of a NACE method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-B-CD. Paper presented at 29th International Symposium on High Perfomance Liquid Phase Separations and Related Techniques, Stockholm, Sweden.

bodson, C., Hubert, P., & Delattre, L. (20 May 2005). instrumentation of a high shear mixer for in-line monitoring of a pharmaceutical blending process using FT-NIR spectroscopy.

Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., Hubert, P., & Crommen, J. (11 March 2005). Influence of the nature of the electrolyte on the chiral separation of basic compounds in nonaqueous capillary electrophoresis using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin. Journal of Chromatography. A, 1068 (1), 143-150. doi:10.1016/j.chroma.2004.12.010
Peer Reviewed verified by ORBi

Chiap, P., Piette, M., Evrard, B., Frankenne, F., Christiaens, B., Piel, G., Cataldo, D., Foidart, J.-M., Delattre, L., Crommen, J., & Hubert, P. (05 March 2005). Automated method for the determination of a new matrix metalloproteinase inhibitor in ovine plasma and serum by coupling of restricted access material for on-line sample clean-up to liquid chromatography. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817 (1), 109-117. doi:10.1016/j.jchromb.2004.08.042
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., & Hubert, P. (2005). Rapport de recherche : Mise au point et validation de méthodes de dosage en vue de l’établissement d’une monographie et de son utilisation dans une étude de stabilité. Synthèse de nouvelles entités chimiques (NEC). (Rapport N°4 (et final)). Liège, Belgium: ULg.

Marini Djang'Eing'A, R., Boulanger, B., Vanderheyden, Y., Chiap, P., Crommen, J., & Hubert, P. (21 February 2005). Uncertainty assessment from robustness testing applied on an LC assay for R-timolol and other related substances in S-timolol maleate. Analytica Chimica Acta, 531 (1), 131-140. doi:10.1016/j.aca.2004.10.004
Peer Reviewed verified by ORBi

Streel, B., Ceccato, A., Klinkenberg, R., & Hubert, P. (25 January 2005). Validation of a liquid chromatographic-tandem mass spectrometric method for the determination of loperamide in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 814 (2), 263-273. doi:10.1016/j.jchromb.2004.10.050
Peer Reviewed verified by ORBi

Rbeida, O., Chiap, P., Lubda, D., Boos, K. S., Crommen, J., & Hubert, P. (04 January 2005). Development and validation of a fully automated LC method for the determination of cloxacillin in human plasma using anion exchancre restricted access material for sample clean-up. Journal of Pharmaceutical and Biomedical Analysis, 36 (5), 961-968. doi:10.1016/j.jpba.2004.09.017
Peer Reviewed verified by ORBi

Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., Crommen, J., & Chiap, P. (04 January 2005). Integrated on-line sample clean-up using cation exchange restricted access sorbent for the LC determination of atropine in human plasma coupled to UV detection. Journal of Pharmaceutical and Biomedical Analysis, 36 (5), 947-954. doi:10.1016/j.jpba.2004.08.007
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Matthijs, N., Vanderheyden, Y., Smeyers-Verbeke, J., Dehouck, P., Hoogmartens, J., Silvestre, P., Ceccato, A., Goedert, P., Saevels, J., Herbots, C., Caliaro, G., Herraez-Hernandez, R., Verdu-Andres, J., Campins-falco, P., de Wauw, W. V., De Beer, J., Boulanger, B., Chiap, P., & Hubert, P. (2005). Collaborative study of an liquid chromatographic method for the determination of R-timolol and other related substances in S-timolol maleate. Analytica Chimica Acta, 546 (2), 182-192. doi:10.1016/j.aca.2005.05.026
Peer Reviewed verified by ORBi

Rozet, E., Wascotte, V., Lecouturier, N., Preat, V., Dewe, W., Boulanger, B., & Hubert, P. (2005). USE OF THE ACCURACY PROFILE FOR THE VALIDATION OF A DIACETYL-MONOXIME COLORIMETRIC METHOD FOR THE DETERMINATION OF UREA IN TRANSDERMAL IONTOPHORETIC EXTRACTS. Poster session presented at RDPA - Recent Development in Pharmaceutical Analysis.

Rozet, E., Mertens, B., Dewe, W., Govaerts, B., Boulanger, B., Chiap, P., Streel, B., Crommen, J., & Hubert, P. (2005). USING TOTAL ERROR AS DECISION CRITERION IN METHOD TRANSFER. Poster session presented at RDPA-Recent Development on Pharmaceutical Analysis.

Rozet, E., Chiap, P., Dewe, W., Boulanger, B., Crommen, J., & Hubert, P. (2005). The Usefulness of Accuracy Profile to Validate Analytical Methods. Paper presented at RDPA - Recent Developement in Pharmaceutical Analysis.

Chiap, P., Rbeida, O., Lubda, D., Boos, K. S., Crommen, J., & Hubert, P. (2005). Development and validation of a LC method for the determination of cloxacillin in plasma using anion exchange restricted access material for on-line sample clean-up. Poster session presented at 29th international symposium on high performance liquid phase separations and related techniques, Stockholm, Sweden.

Eppe, G., Boulanger, B., Hubert, P., Scippo, M.-L., Maghuin-Rogister, G., & De Pauw, E. (2005). Evaluating measurement uncertainty for dioxins in routine analysis by the accuracy profile approach. Poster session presented at 2nd symposium on recent advances in food analysis, Prague, Czechia.

Ziemons, E., Otte, X., Lejeune, R., Rozet, E., Thunus, L., & Hubert, P. (2005). Determination of fenofibrate, ciprofibrate and bezafibrate in mixtures by FTIR spectroscopy. Poster session presented at 11th meeting on Recent Developments in Pharmaceutical Analysis, Rimini, Italy.

Martin, G., Chiap, P., Paquet, P., Pierard, G., Hubert, P., & Crommen, J. (2005). Determination of catecholamines in human plasma using solid phase extraction and LC-ESI-MS-MS. Poster session presented at 29th international symposium on high performance liquid phase separations and related techniques, Stockholm, Sweden.

Chiap, P., Boulanger, B., Dewé, W., Crommen, J., & Hubert, P. (2005). Recent trends in the validation of bioanalytical methods. Paper presented at PharmSciFair, Nice, France.

Rozet, E., Dewe, W., Chiap, P., Lecomte, F., & Hubert, P. (2005). Le transfert d’une méthode de dosage de 3 catécholamines majeures dans l’urine humaine: utilisation de l’erreur totale comme critère de décision. Paper presented at 3èmes Journées Internationales de Toxicologie Hospitalière.

Chiap, P., Rbeida, O., Boos, K. S., Hubert, P., & Crommen, J. (2005). Recent developments in on-line coupling of SPE to LC using restricted access materials with different functionalities. Paper presented at International seminar on solid-phase extraction in clinical and biopharmaceutical samples, Maastricht, Netherlands.

Rozet, E., Dewé, W., Chiap, P., Lecomte, F., & Hubert, P. (2005). Le transfert d’une méthode de dosage automatisée de 3 catécholamines majeures dans l’urine humaine: utilisation de l’erreur totale comme critère de décision. Paper presented at 3èmes Journées Internationales de Toxicologie Hospitalière, Liege, Belgium.

Rozet, E., & Hubert, P. (2005). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°3. (3).

Crommen, J., Servais, A.-C., Fradi, I., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Fillet, M. (2005). Enantiomeric separation of acidic and basic chiral drugs in non-aqueous capillary electrophoresis using cyclodextrin with the opposite charge. Paper presented at 11th meeting on recent developments in pharmaceutical analysis (RDPA), Rimini, Italy.

Block, S., Brkic, D., Hubert, P., & Quetin-Leclercq, J. (2005). A validated method for the quantification of pimarane and trachylobane diterpenes in the leaves of Croton zambesicus by capillary gas chromatography. Phytochemical Analysis, 16 (5, SEP-OCT), 342-348. doi:10.1002/pca.855
Peer Reviewed verified by ORBi

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (28 December 2004). Development of response models for optimising HPLC methods. Chemometrics and Intelligent Laboratory Systems, 74 (2), 263-268. doi:10.1016/j.chemolab.2004.04.016
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., & Valat, L. (15 November 2004). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - part I. Journal of Pharmaceutical and Biomedical Analysis, 36 (3), 579-586. doi:10.1016/j.jpba.2004.07.027
Peer Reviewed verified by ORBi

Christiaens, B., Fillet, M., Chiap, P., Rbeida, O., Ceccato, A., Streel, B., De Graeve, J., Crommen, J., & Hubert, P. (12 November 2004). Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up. Journal of Chromatography. A, 1056 (1-2), 105-110. doi:10.1016/j.chroma.2004.06.107
Peer Reviewed verified by ORBi

Feinberg, M., Boulanger, B., Dewé, W., & Hubert, P. (October 2004). New advances in method validation and measurement uncertainty aimed at improving the quality of chemical data. Analytical and Bioanalytical Chemistry, 380 (3), 502-514. doi:10.1007/s00216-004-2791-y
Peer Reviewed verified by ORBi

Henry de Hassonville, S., Chiap, P., Liégeois, J.-F., Evrard, B., Delattre, L., Crommen, J., Piel, G., & Hubert, P. (21 September 2004). Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin. Journal of Pharmaceutical and Biomedical Analysis, 36 (1), 133-143. doi:10.1016/j.jpba.2004.05.023
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., & Hubert, P. (2004). Rapport de recherche : Mise au point et validation de méthodes de dosage en vue de l’établissement d’une monographie et de son utilisation dans une étude de stabilité. Synthèse de nouvelles entités chimiques (NEC). (Rapport N°3). Liège, Belgium: ULg.

Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., Hubert, P., & Crommen, J. (August 2004). Enantiomeric separation of basic compounds usin heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin in combination with potassium camphorsulfonate in nonaqueous capillary electrophoresis: Optimization by means of an experimental design. Electrophoresis, 25 (16), 2701-2710. doi:10.1002/elps.200405962
Peer Reviewed verified by ORBi

Stevigny, C., Wautier, M. C., Jiwan, J. L. H., Chiap, P., Hubert, P., & Quetin-Leclercq, J. (August 2004). Development and validation of a high performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis. Planta Medica, 70 (8), 764-770. doi:10.1055/s-2004-827209
Peer Reviewed verified by ORBi

Rozet, E., & Hubert, P. (2004). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°2. (2).

Servais, A.-C., Chiap, P., Hubert, P., Crommen, J., & Fillet, M. (June 2004). Determination of salbutamol enantiomers in human urine using heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin in nonaqueous capillary electrophoresis. Electrophoresis, 25 (10-11), 1632-1640. doi:10.1002/elps.200405854
Peer Reviewed verified by ORBi

Henry de Hassonville, S., Christiaens, B., Piel, G., Barillaro, V., Bertholet, P., Chiap, P., Hubert, P., Crommen, J., Delattre, L., Pierard, G., & Evrard, B. (May 2004). Effect of methylated-b-cyclodextrin on the skin and influence on cyproterone acetate percutaneous absorption. Poster session presented at XII th International Cyclodextrin Symposium, Montpellier, France.

Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., Crommen, J., & Chiap, P. (19 March 2004). Evaluation of a novel anion-exchange restricted-access sorbent for on-line sample clean-up prior to the determination of acidic compounds in plasma by liquid chromatography. Journal of Chromatography. A, 1030 (1-2), 95-102. doi:10.1016/j.chroma.2003.11.031
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., & Hubert, P. (2004). Rapport de recherche : Mise au point et validation de méthodes de dosage en vue de l’établissement d’une monographie et de son utilisation dans une étude de stabilité. Synthèse de nouvelles entités chimiques (NEC). (Rapport N°2). Liège, Belgium: ULg.

Marini Djang'Eing'A, R., Boulanger, B., Abushoffa, A., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (February 2004). ENANTIOMERIC PURITY TESTING OF S-KETOPROFEN IN PHARMACEUTICAL FORMULATIONS BY CE USING A DUAL CYCLODEXTRIN SYSTEM. Poster session presented at 17th International Symposium on Microscale Separations and Capillary Electrophoresis, Salzburg, Austria.

Christians, B., Fillet, M., Chiap, P., Rbeida, O., Ceccato, A., Streel, B., De Graeve, J., Crommen, J., & Hubert, P. (2004). Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up. Journal of Chromatography. A, 1056 (1-2), 105-10.
Peer Reviewed verified by ORBi

Servais, A.-C., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (2004). First application of non-aqueous capillary electrophoresis for the determination of the enantiomers of a basic chiral drug in biological samples: Quantification of salbutamol in human urine. Poster session presented at 15th International Symposium on pharmaceutical and biomedical analysis (PBA), Florence, Italy.

Crommen, J., Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., & Hubert, P. (2004). Enantiomeric separation of ionisable compounds in non-aqueous capillary electrophoresis using charged cyclodextrins in combination with ion-pairing reagents. Paper presented at 25th International Symposium on Chromatography (ISC 04), Paris, France.

Crommen, J., Servais, A.-C., Fillet, M., Chiap, P., & Hubert, P. (2004). Enantiomeric separation in non-aqueous capillary electrophoresis using charged cyclodextrins in combination with other ionic additives. Paper presented at 15th International Symposium on pharmaceutical and biomedical analysis (PBA), Florence, Italy.

Servais, A.-C., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (2004). Validation d’une méthode de dosage des énantiomères du salbutamol dans l’urine par électrophorèse capillaire en milieu non aqueux en utilisant une cyclodextrine anionique comme sélecteur chiral. Poster session presented at Forum labo et forum biotech, Paris, France.

Chiap, P., Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (2004). Evaluation of novel restricted access sorbents with ion exchange properties for on-line sample clean-up prior to the LC determination of acidic of basic compounds in plasma. Poster session presented at 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Servais, A.-C., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (2004). Determination of salbutamol enantiomers in human urine using anionic cyclo-dextrins in non-aqueous capillary electrophoresis. Poster session presented at 17th International Symposium on Microscale Separations an Capillary Electro-phoresis, Salzburg, Austria.

Hubert, P., Boulanger, B., Dewé, W., Chiap, P., & Crommen, J. (2004). Harmonisation des stratégies de validation, utopie ou réalité ? Paper presented at Forum labo et forum biotech, Paris, France.

Boulanger, B., Dewé, W., & Hubert, P. (2004). Objectives of analytical methods and objectives of validation. How to reconcile them ? Paper presented at 4th international workshop on statistical methods in non-clinical R et D, Dublin, Ireland.

Rudaz, S., Rollason, V., Desmeules, J., Dayer, P., Veuthey, J. L., Boulanger, B., & Hubert, P. (2004). Impact of calibration models for the validation of a liquid chromatography method for paracetamol, tramadol and its main o-desmethylated metabolite in serum samples. Paper presented at 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Bimazubute, M., Chiap, P., Janssen, L., Gustin, P., Crommen, J., & Hubert, P. (2004). Automated determination of oxytetracycline in plasma of healthy pigs by at-line coupling of solid phase extraction to liquid chromatography. Poster session presented at 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Chiap, P., Dewé, W., Boulanger, B., Crommen, J., & Hubert, P. (2004). Use of accuracy profiles as efficient decision tool for the validation of quantitative analytical methods. Poster session presented at 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Block, S., Brkic, D., Hubert, P., & Quetin-Leclercq, J. (2004). A validated method for the quantification of pimarane and trachylobane diterpenes in the leaves of Croton zambesicus by capillary gas chromatography. Paper presented at International congress on natural products research (ICNPR), Phoenix, United States.

Laurentie, M., Manceau, J., Dewé, W., Boulanger, B., & Hubert, P. (2004). The use of total error to validate analytical method : examples of applications. Paper presented at Second international conference on antimicrobial agents in veterinary medicine, Ottawa, Canada.

Dewé, W., Boulanger, B., & Hubert, P. (2004). Towards a better use of statistics in method validation. Paper presented at Applied statistics workshop, Bruxelles, Belgium.

Boulanger, B., Dewé, W., & Hubert, P. (2004). Validation of quantitation methods. Paper presented at Bioforum, Liège, Belgium.

Crommen, J., Rbeida, O., Chiap, P., Christiaens, B., Lubda, D., & Hubert, P. (2004). Evaluation de nouvelles phases à accès restreint échangeuses d’ions pour l’extraction sélective de comosoés médicamenteux dans le plasma avant leur analyse chromatographique. Poster session presented at Forum labo et forum biotech, Paris, France.

Hubert, P., Chiap, P., Dormal, C., Crommen, J., Dewé, W., & Boulanger, B. (2004). Intérêt du profil d'exactitude dans le cadre de la validation des méthodes analytiques. Poster session presented at Forum labo et Forum biotech, Paris, France.

Christiaens, G., Chiap, P., Fillet, M., Rbeida, O., Ceccato, A., Streel, B., De Graeve, J., Crommen, J., & Hubert, P. (2004). New fully automated method for the LC-MS/MS determination of cyproterone acetate in human plasma using restricted access material for sample clean-up. Poster session presented at 8th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-8), Bruges, Belgium.

Crommen, J., Servais, A.-C., Fillet, M., Chiap, P., Dewé, W., & Hubert, P. (2004). Enantiomeric separation of basic drugs using anionic cyclodextrins in non-aqueous capillary electrophoresis : optimization of the background electrolyte composition. Paper presented at 17th International Symposium on Microscale Separations an Capillary Electro-phoresis, Salzburg, Austria.

Crommen, J., Servais, A.-C., Fillet, M., & Hubert, P. (2004). Enantioseparation of basic pharmaceuticals in non-aqueous capillary electrophoresis using anionic cyclodextrins as chiral selectors. Paper presented at 12th International Cyclodextrin Symposium, Montpellier, France.

Henry de Hassonville, S., Christiaens, B., Piel, G., Barillaro, V., Bertholet, P., Chiap, P., Hubert, P., Crommen, J., Delattre, L., Pierard, G., & Evrard, B. (2004). La Rameb, un promoteur d’absorption cutanée pour l’acétate de cypro-térone ? Paper presented at 7e journées du club cyclodextrines, Lille, France.

Stevigny, C., Wautier, M. C., Chiap, P., Hubert, P., & Quetin-Leclercq, J. (2004). Quantification of aporphines in cassytha filiformis bu HPLC/UV : validation and application. Poster session presented at IUPAC Satellite Symposium Bioresources Towards Drug Discovery and Development, Mauritius.

Boulanger, B., Dewé, W., & Hubert, P. (2004). Setting acceptance criteria and total error criteria. Paper presented at Bioval 2004, London, United Kingdom.

Rozet, E., & Hubert, P. (2004). TRANSVAL - Convention FIRST EUROPE n°215269 - rapport semestriel n°1. (1).

Stevigny, C., Wautier, M. C., Habib Jiwan, J.-L., Chiap, P., Hubert, P., & Quetin-Leclercq, J. (2004). Development and validation of a high-performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis L. Paper presented at Future trends in phytochemistry, Gargnano, Italy.

Herchuelz, A., Carreer-Bruhwyler, F., Crommen, J., Chiap, P., Hubert, P., Messin, R., Dubois, C., Famaey, J.-P., & Géczy, J. (2004). Clinical pharmacokinetics of once-daily molsidomine - From immediate-release to prolonged-release once-daily formulations. American Journal of Drug Delivery, 2 (2), 131-141. doi:10.2165/00137696-200402020-00005
Peer Reviewed verified by ORBi

Christiaens, B., Chiap, P., Rbeida, O., Cello, D., Crommen, J., & Hubert, P. (25 September 2003). Fully automated method for the liquid chromatographic determination of cyproterone acetate in plasma using restricted access material for sample pre-treatment. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 795 (1), 73-82. doi:10.1016/S1570-0232(03)00517-8
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., & Hubert, P. (2003). Rapport de Recherche : Mise au point et validation de méthodes de dosage en vue de l’établissement d’une monographie et de son utilisation dans une étude de stabilité. Synthèse de nouvelles entités chimiques (NEC). (Rapport N°1). Liège, Belgium: ULg.

Ceccato, A., Klinkenberg, R., Hubert, P., & Streel, B. (08 August 2003). Sensitive determination of buprenorphine and its N-dealkylated metabolite norbuprenorphine in human plasma by liquid chromatography coupled to tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), 619-631. doi:10.1016/S0731-7085(03)00169-9
Peer Reviewed verified by ORBi

Rbeida, O., Christiaens, B., Chiap, P., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (08 August 2003). Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up. Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), 829-838. doi:10.1016/S0731-7085(03)00186-9
Peer Reviewed verified by ORBi

Boulanger, B., Chiap, P., Dewé, W., Crommen, J., & Hubert, P. (08 August 2003). An analysis of the SFSTP guide on validation of chromatographic bioanalytical methods: progresses and limitations. Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), 753-765. doi:10.1016/S0731-7085(03)00182-1
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Chiap, P., & Hubert, P. (2003). NORMS AND GUIDELINES FOR THE PRACTICAL ESTIMATION OF UNCERTAINTY IN ANALYTICAL MEASUREMENTS. (Final rapport). Liège, Belgium: ULg.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Dewé, W., Hubert, P., & Crommen, J. (July 2003). LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design. Journal of Separation Science, 26 (9-10), 809-817. doi:10.1002/jssc.200301367
Peer Reviewed verified by ORBi

Messin, R., Fenyvesi, T., Carreer-Bruhwyler, F., Crommen, J., Chiap, P., Hubert, P., Dubois, C., Famaey, J. P., & Geczy, J. (July 2003). A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations. European Journal of Clinical Pharmacology, 59 (3), 227-232. doi:10.1007/s00228-003-0597-z
Peer Reviewed verified by ORBi

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Boulanger, B. (June 2003). Development of response models for optimizing HPLC methods. Poster session presented at 27th Symposium on High Performance Liquid Phase Separations and Related Techniques, Nice, France.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Hubert, P., & Crommen, J. (May 2003). ASSESSMENT OF UNCERTAINTY FROM ROBUSTNESS TESTING OF A LC METHOD FOR THE DETERMINATION OF R-TIMOLOL AND OTHER RELATED SUBSTANCES IN S-TIMOLOL MALEATE. Paper presented at 11th Forum of the Pharmaceutical Sciences, Spa, Belgium.

Dehouck, P., Vander Heyden, Y., Smeyers-Verbecke, J., Massart, D. L., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., Van de Wauw, De Beer, Cox, R., Reepmeyer, Voigt, B., Estevenon, O., Nicolas, A., Van Schepdael, A., Adams, E., Hoogmartens, J., & Mathieu, G. (May 2003). Determination of uncertainty in a liquid chromatographic method for erythromycin from Interlaboratory study results. Paper presented at 11th Forum of the Belgian Society of Pharmaceutical Sciences (SBSP 2003), Spa, Belgium.

Hubert, P., Nguyen-Huu, J. J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P. A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivert, C., & Valat, L. (May 2003). Validation des procédures analytiques quantitatives, Harmonisation des démarches. STP Pharma Pratiques, 13 (3), 101-138.
Peer reviewed

Dehouck, P., Vander Heyden, Y., Smeyers-Verbeke, J., Massart, D. L., Crommen, J., Hubert, P., Marini Djang'Eing'A, R., Smeets, O. S. N. M., Decristoforo, G., Van de Wauw, W., De Beer, J., Quaglia, M. G., Stella, C., Veuthey, J.-L., Estevenon, O., Van Schepdael, A., Roets, E., & Hoogmartens, J. (17 January 2003). Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample. Analytica Chimica Acta, 481, 261-272. doi:10.1016/S0003-2670(03)00079-5
Peer Reviewed verified by ORBi

Servais, A.-C., Fillet, M., Abushoffa, A. M., Hubert, P., & Crommen, J. (2003). Synergistic effects of ion-pairing in the enantiomeric separation of basic compounds with cyclodextrin derivatives in nonaqueous capillary electrophoresis. Electrophoresis, 24 (3), 363-369. doi:10.1002/elps.200390046
Peer Reviewed verified by ORBi

Dehouck, P., Vander Heyden, Y., Smeyers-Verbeke, J., Massart, D. L., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., Van de Wauw, W., De Beer, J., Cox, R., Mathieu, G., Reepmeyer, J. C., Voigt, B., Estevenon, O., Nicolas, A., Van Schepdael, A., Adams, E., & Hoogmartens, J. (2003). Interlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty. Journal of Chromatography. A, 1010 (1), 63-74. doi:10.1016/S0021-9673(03)01023-9
Peer Reviewed verified by ORBi

Laurentie, M., Boulanger, B., Dewé, W., & Hubert, P. (2003). Statistical analysis of validation method revisited : the need to use the total error. Proceeding 9th international congress of the european association for Veterinary Pharmacology and Toxicology. Journal of Veterinary Pharmacology and Therapeutics, 26, 302-303.
Peer Reviewed verified by ORBi

Hubert, P. (2003). Normes et textes en vigueur pour la validation. Paper presented at Symposium AFSEP (association francophone des sciences séparatives), Lyon, France.

Crommen, J., Servais, A.-C., Dewé, W., Chiap, P., Fillet, M., & Hubert, P. (2003). Enantiomeric separation of basic pharmaceuticals in non-aqueous capillary electrophoresis using an anionic cyclodextrin in combination with an ion-pairing reagent. Paper presented at 3th International Symposium on Separations in Biosciences (SBS 2003), Moscow, Russia.

Crommen, J., Servais, A.-C., Fillet, M., & Hubert, P. (2003). New approaches for enantiomeric separation in non-aqueous camillary electrophoresis (NACE). Paper presented at 4th International Symposium on Pharmaceutical Chemistry, Istanbul, Turkey.

Servais, A.-C., Dewé, W., Chiap, P., Fillet, M., Abushoffa, A., Hubert, P., & Crommen, J. (2003). Separation énatiomérique de substances médicamenteuses basiques par électrophorèse capillarie en milieu non aqueux : effet de l’utilisation simul-tanée d’une cyclodextrine anionique et d’un agent d’appariement d’ions. Paper presented at 5e Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Hubert, P., Chiap, P., Laurentie, M., Dewé, W., Boulanger, B., & Crommen, J. (2003). Harmonisation des démarches de validation, est-elle possible ? Paper presented at 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2003). Objectives of analytical methods and objectives of validation. Paper presented at Landolake conference, Wisconsin, United States.

Henry de Hassonville, S., Christiaens, B., Piel, G., Barillaro, V., Bertholet, P., Chiap, P., Hubert, P., Crommen, J., Delattre, L., Pierard, G., & Evrard, B. (2003). Cyclodextrins as topical permeation enhancers : in vitro and in vivo testing. Poster session presented at Symposium skin and formulation APGI, Paris, France.

Hubert, P., Chiap, P., Dewé, W., Boulanger, B., & Crommen, J. (2003). Harmonization of validation strategies for analytical methods. Paper presented at 4th international symposium on pharmaceutical chemistry, Istanbul, Turkey.

Abushoffa, A. M., Fillet, M., Servais, A.-C., Hubert, P., & Crommen, J. (2003). Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis. Electrophoresis, 24 (3), 343-50. doi:10.1002/elps.200390044
Peer Reviewed verified by ORBi

Chiap, P., Crommen, J., Dormal, C., Dewé, W., Boulanger, B., & Hubert, P. (2003). Intérêt du profil d’exactitude dans le cadre de la validation d’une méthode de dosage par chromatographie liquide du miconazole, de l’éconazole et du sor-bate dans les préparations à usage dermatologie. Poster session presented at 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Martin, Y., Reynders, V., Chiap, P., Dormal, C., Hubert, P., & Crommen, J. (2003). Intérêt du profil d’exactitude dans le cadre de la validation d’une méthode de dosage par chromatographie liquide du miconazole, de l’éconazole et du sor-bate dans les préparations à usage dermatologie. Poster session presented at 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Boulanger, B., Marini Djang'Eing'A, R., Chiap, P., Dewé, W., Crommen, J., & Hubert, P. (2003). Objectives of analytical methods and objectives of validation : how to reconciliate them ? Paper presented at HPLC 2003, 27th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Nice, France.

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (2003). Development of response models for optimising HPLC methods. Poster session presented at HPLC ‘03, 27th International Symposium on High Performance Liquid Phase Separations an Related Techniques, Nice, France.

Laurentie, M., Boulanger, B., Dewé, W., & Hubert, P. (2003). Statistical analysis of validation method revisited : the need to use the total error. Paper presented at 9th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Lisboa, Portugal.

Crommen, J., Servais, A.-C., Fillet, M., Abushoffa, A., Chiap, P., & Hubert, P. (2003). Modulation of selectivity for the enantiomeric separation of basic compounds in non-aqueous CE using anionic cyclodextrins in combination with ion-pairing re-agents. Paper presented at 27th International Symposium on high performance liquid phase separations and related techniques, Nice, France.

Abushoffa, A. M., Fillet, M., Marini Djang'Eing'A, R., Hubert, P., & Crommen, J. (2003). Enantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems. Journal of Separation Science, 26 (6-7), 536-542. doi:10.1002/jssc.200390073
Peer Reviewed verified by ORBi

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (December 2002). Développement de modèles de réponse pour l’optimisation de méthodes HPLC. Paper presented at Chimiométrie 2002, Paris, France.

Servais, A.-C., Fillet, M., Chiap, P., Abushoffa, A. M., Hubert, P., & Crommen, J. (December 2002). Optimization of the separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media using univariate and multivariate approaches. Journal of Separation Science, 25 (15-17), 1087-1095. doi:10.1002/1615-9314(20021101)25:15/17<1087::AID-JSSC1087>3.0.CO;2-A
Peer Reviewed verified by ORBi

Chiap, P., Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (25 October 2002). Use of a novel cation-exchange restricted-access material for automated sample clean-up prior to the determination of basic drugs in plasma by liquid chromatography. Journal of Chromatography. A, 975 (1), 145-155. doi:10.1016/S0021-9673(02)01334-1
Peer Reviewed verified by ORBi

Dehouck, P., Vander Heyden, Y., Smeyers-Verbecke, J., Massart, D. L., Crommen, J., Hubert, P., Marini Djang'Eing'A, R., Smeets, O. S. N. M., Decristoforo, G., Van de Wauw, W., De Beer, J., Quaglia, M. G., Stella, C., Veuthey, J.-L., Estevenon, O., Van Schepdael, A., Roets, E., & Hoogmartens, J. (April 2002). Determination of uncertainty in analytical measurements: Collaborative study of the analysis of phenoxymethylpenicillin. Poster session presented at VIIth International Symposium on Drug Analysis, Bruges, Belgium.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Dewé, W., Hubert, P., & Crommen, J. (April 2002). DEVELOPMENT AND VALIDATION OF A SIMULTANEOUS LC METHOD FOR THE DETERMINATION OF S-TIMOLOL MALEATE, ITS ANTIPODE AND RELATED SUBSTANCES USING A CELLULOSE BASED CHIRAL STATIONARY PHASE. Poster session presented at Drug Analysis 2002 Symposium, Bruges, Belgium.

Marini Djang'Eing'A, R., Pantella, A., Bimazubute, M., Chiap, P., Hubert, P., & Crommen, J. (March 2002). Optimisation and validation of a generic method for the LC assay of six corticosteroids and salicylic acid in dermopharmaceutical forms. Chromatographia, 55 (5-6), 263-269. doi:10.1007/BF02491657
Peer reviewed

Chiap, P., Hubert, P., & Crommen, J. (01 March 2002). Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography. Journal of Chromatography. A, 948 (1-2), 151-161. doi:10.1016/S0021-9673(01)01318-8
Peer Reviewed verified by ORBi

Chiap, P., Ceccato, A., Gora, R., Hubert, P., Geczy, J., & Crommen, J. (15 January 2002). Automated determination of pirlindole enantiomers in plasma by on-line coupling of a pre-column packed with restricted access material to a chiral liquid chromatographic column. Journal of Pharmaceutical and Biomedical Analysis, 27 (3-4), 447-455. doi:10.1016/S0731-7085(01)00647-1
Peer Reviewed verified by ORBi

Abushoffa, A. M., Fillet, M., Hubert, P., & Crommen, J. (2002). Prediction of selectivity for enantiomeric separations of uncharged compounds by capillary electrophoresis involving dual cyclodextrin systems. Journal of Chromatography. A, 948 (1-2), 321-9. doi:10.1016/S0021-9673(01)01371-1
Peer Reviewed verified by ORBi

Kabengera, C., Bodart, P., Hubert, P., Thunus, L., & Noirfalise, A. (2002). Optimization and validation of arsenic determination in foods by hydride generation flame atomic absorption spectrometry. Journal of AOAC International, 85 (1, Jan-Feb), 122-127. doi:10.1093/jaoac/85.1.122
Peer Reviewed verified by ORBi

Crommen, J., Abushoffa, A., Fillet, M., & Hubert, P. (2002). The design of dual systems for amplification of selectivity in CE enantioseparations. Paper presented at 15th International Symposium on Microscale Separations and Analyses (HPCE 2002), Stockholm, Sweden.

Rbeida, O., Christiaens, B., Chiap, P., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (2002). The use of a novel cation exchange restricted access material for automated sample clean-up prior to the determination of basic drugs in plasma by liquid chromatography. Poster session presented at 7th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC 7), Bruges, Belgium.

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2002). Objectives of validation : the statistical rationale of the SFSTP. Paper presented at Bioval 2002, London, United Kingdom.

Abushoffa, A., Fillet, M., Servais, A.-C., Hubert, P., & Crommen, J. (2002). Enantioseparation of uncharged compounds using combinations of octakis-(2,3-dihydroxy-6-sulfato)--cyclodextrin and heptakis-(2,3,6-tri-O-methyl)--cyclodextrin in capillary electrophoresis. Poster session presented at 26th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2002), Montreal, Canada.

Servais, A.-C., Fillet, M., Chiap, P., Abushoffa, A., Hubert, P., & Crommen, J. (2002). Multivariate optimization approach for the separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media. Poster session presented at 7th International Symposium on Drug Analysis, Bruges, Belgium.

Abushoffa, A., Fillet, M., Hubert, P., & Crommen, J. (2002). Selectivity enhancement for the CE enantioseparation of uncharged compounds using mixtures of cationic and anionic cyclodextrin derivatives. Poster session presented at 15th International Symposium on Microscale Separations and Analyses (HPCE 2002), Stockholm, Sweden.

Hubert, P., Chiap, P., Dormal, C., Dewé, W., Boulanger, B., & Crommen, J. (2002). Statistical analysis of the validation results: diagnostic or decision tools. Paper presented at 7th International Symposium on Drug Analysis, Bruges, Belgium.

Hubert, P. (2002). Aspects reglementaires liés à la validation des méthodes de contrôle. Paper presented at 7e journées scientifiques CCCTA, les Diablerets, France.

Christiaens, B., Cello, D., Chiap, P., Rbeida, O., Hubert, P., & Crommen, J. (2002). Fully automated method for the liquid chromatographic determination of cyproterone acetate in plasma using restricted access material for sample pre-treatment. Poster session presented at 7th International Symposium on Drug Analysis, Bruges, Belgium.

Chiap, P., Lambert, E., Dormal, C., Hubert, P., Dewé, W., & Boulanger, B. (2002). Use of the accuracy profile for the validation of a generic LC method for the determination of miconazole, econazole and sorbate in dermatological forms. Poster session presented at 7th International Symposium on Drug Analysis, Bruges, Belgium.

Chiap, P., Rbeida, O., Christiaens, B., Hubert, P., Lubda, D., Boos, K. S., & Crommen, J. (2002). Evaluation of a new kind of cation exchange restricted access sorbent for on-line solid phase extraction of basic drugs from plasma prior to their determination by liquid chromatography. Poster session presented at 7th International Symposium on Drug Analysis, Bruges, Belgium.

Hubert, P., Chiap, P., Dormal, C., Boulanger, B., Dewé, W., & Crommen, J. (2002). Intérêt du profil d'exactitude dans le cadre de la validation des méthodes analytiques. Paper presented at Forum Labo, Paris, France.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2002). Objectifs des méthodes analytiques et objectifs de la validation. Comment les réconcilier pour garantir la qualité des résultats ? Paper presented at Chimiométrie, Paris, France.

Hubert, P., Chiap, P., Dormal, C., Crommen, J., Dewé, W., & Boulanger, B. (2002). Intérêt du profil d’exactitude dans le cadre de la validation des méthodes ana-lytiques. Paper presented at Club chimiométrie et assurance qualité, INRA, Paris, France.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2002). Objectives and analytical methods and objectives of validation. Paper presented at Barnett Conference, Philadelphie, United States.

Crommen, J., Servais, A.-C., Abushoffa, A., Fillet, M., & Hubert, P. (2002). Selectivity enhancement in chiral and achiral separations of basic drugs by ion-pairing in non-aqueous capillary electrophoresis. Paper presented at 26th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2002), Montreal, Canada.

Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Crommen, J. (June 2001). SIMULTANEOUS LC DETERMINATION OF R-TIMOLOL MALEATE AND OTHER CLOSELY RELATED IMPURITIES IN S-TIMOLOL MALEATE USING A CELLULOSE BASED CHIRAL STATIONARY PHASE. Poster session presented at 25th International Symposium on High Performance Liquid Phase Separations andr Related Technique, Maastricht, Netherlands.

Marini Djang'Eing'A, R., Chiap, P., Hubert, P., & Crommen, J. (25 May 2001). Separation and simultaneous determination of S-timolol maleate, its optical antipode and related substances by liquid chromatography using a cellulose based chiral stationary phase. Paper presented at 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Toussaint, B., Palmer, M., Chiap, P., Hubert, P., & Crommen, J. (April 2001). On-Line Coupling of Partial Filling-Capillary Zone Electrophoresis with Mass Spectrometry for the Separation of Clenbuterol Enantiomers. Electrophoresis, 22 (7), 1363-72. doi:10.1002/1522-2683(200105)22:7<1363::AID-ELPS1363>3.0.CO;2-Q
Peer Reviewed verified by ORBi

Chiap, P., Ceccato, A., Miralles Buraglia, B., Boulanger, B., Hubert, P., & Crommen, J. (March 2001). Development and Validation of an Automated Method for the Liquid Chromatographic Determination of Sotalol in Plasma Using Dialysis and Trace Enrichment on a Cation-Exchange Pre-Column as on-Line Sample Preparation. Journal of Pharmaceutical and Biomedical Analysis, 24 (5-6), 801-14. doi:10.1016/S0731-7085(00)00547-1
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., & Crommen, J. (2001). Strategy for the development of automated methods using dialysis and trace enrichment as on-line sample preparation techniques for the LC determination of drugs in plasma. Poster session presented at HPLC 2001, Maastricht, Netherlands.

Hubert, P., Boulanger, B., Chiap, P., Dewé, W., & Crommen, J. (2001). Développements récents dans le domaine de la validation de méthodes en analyse pharmaceutique et biomédicale. Paper presented at SEP 2001, Paris, France.

Crommen, J., Abushoffa, A., Fillet, M., & Hubert, P. (2001). Prédiction de la sélectivité lors de séparations chirales en électrophorèse capillaire à l’aide de mélanges de cyclodextrines (systèmes duaux). Paper presented at SEP 2001, Paris, France.

Abushoffa, A., Fillet, M., Hubert, P., & Crommen, J. (2001). Prediction of selectivity and resolution in enatiomeric separations of uncharged compounds by capillary electrophoresis using dual cyclodextrin systems. Poster session presented at HPCE 2001, Boston, United States.

Crommen, J., Abushoffa, A., Fillet, M., & Hubert, P. (2001). Optimization of the CE enantioseparation of uncharged compounds in dual cyclodextrin systems. Paper presented at HPCE 2001, Boston, United States.

Crommen, J., Abushoffa, A., Fillet, M., Chankvetadze, B., & Hubert, P. (2001). The use of two chiral selectors in combination for the enantioseparation of drugs by capillary electrophoresis : benefits and limitations. Paper presented at 9th International Meeting on Recent Developments in Pharmaceutical Analysis (RDPA) 2001, Lipari, Aeolian Islands, Messina, Italy.

Abushoffa, A., Fillet, M., Hubert, P., & Crommen, J. (2001). CE determination of binding constants between profen enantiomers and single-isomer anionic and neutral cyclodextrins. Poster session presented at HPLC 2001, Maastricht, Netherlands.

Crommen, J., Abushoffa, A., Fillet, M., & Hubert, P. (2001). Modulation of selectivity for enantiomeric separation in CE using mixtures of cationic and anionic cyclodextrins. Paper presented at HPLC 2001, Maastricht, Netherlands.

Hubert, P., Chiap, P., Dewé, W., Boulanger, B., & Crommen, J. (2001). The usefulness of accuracy profiles in LC method validation. Paper presented at HPLC 2001, Maastricht, Netherlands.

Servais, A.-C., Fillet, M., Hubert, P., & Crommen, J. (2001). Separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media. Poster session presented at HPLC 2001, Maastricht, Netherlands.

Rbeida, O., Christiaens, B., Chiap, P., Hubert, P., & Crommen, J. (2001). A novel cation exchange restricted access material for precolumns in the LC analysis of basic drugs in plasma using the column switching technique. Poster session presented at HPLC 2001, Maastricht, Netherlands.

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2001). Objectives of validation : the statistical rationale of the SFSTP. Paper presented at ISPC, Istanbul, Turkey.

Servais, A.-C., Fillet, M., Hubert, P., & Crommen, J. (2001). Separation of closely related basic drugs by ion-pair capillary electrophoresis in non-aqueous media. Paper presented at Forum des Sciences Pharmaceutiques, Montréal, Canada.

Chiap, P., Boulanger, B., Fotsing, L., Hubert, P., & Crommen, J. (2001). Liquid chromatographic analysis of local anesthetics in human plasma after sample preparation by on-line dialysis. Optimization by use of experimental design. Chromatographia, 53 (11-12), 678-686. doi:10.1007/BF02493020
Peer reviewed

Toussaint, B., Streel, B., Ceccato, A., Hubert, P., & Crommen, J. (27 October 2000). Determination of the Enantiomers of 3-Tert.-Butylamino-1,2-Propanediol by High-Performance Liquid Chromatography Using Mass Spectrometric Detection. Journal of Chromatography. A, 896 (1-2), 201-7. doi:10.1016/S0021-9673(00)00558-6
Peer Reviewed verified by ORBi

Toussaint, B., Pitti, C., Streel, B., Ceccato, A., Hubert, P., & Crommen, J. (27 October 2000). Quantitative Analysis of N-Acetylcysteine and Its Pharmacopeial Impurities in a Pharmaceutical Formulation by Liquid Chromatography-Uv Detection-Mass Spectrometry. Journal of Chromatography. A, 896 (1-2), 191-9. doi:10.1016/S0021-9673(00)00741-X
Peer Reviewed verified by ORBi

Toussaint, B., Duchateau, A. L., van der Wal, S., Albert, A., Hubert, P., & Crommen, J. (October 2000). Comparative Evaluation of Four Detectors in the High-Performance Liquid Chromatographic Analysis of Chiral Nonaromatic Alcohols. Journal of Chromatographic Science, 38 (10), 450-7. doi:10.1093/chromsci/38.10.450
Peer Reviewed verified by ORBi

Toussaint, B., Duchateau, A. L., van der Wal, S., Albert, A., Hubert, P., & Crommen, J. (25 August 2000). Determination of the Enantiomers of 3-Tert.-Butylamino-1,2-Propanediol by High-Performance Liquid Chromatography Coupled to Evaporative Light Scattering Detection. Journal of Chromatography. A, 890 (2), 239-49. doi:10.1016/S0021-9673(00)00609-9
Peer Reviewed verified by ORBi

Fillet, M., Hubert, P., & Crommen, J. (14 April 2000). Enantiomeric Separations of Drugs Using Mixtures of Charged and Neutral Cyclodextrins. Journal of Chromatography. A, 875 (1-2), 123-34. doi:10.1016/S0021-9673(00)00084-4
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Pantella, A., Chiap, P., Bimazubute, M. A., Hubert, P., & Crommen, J. (April 2000). Development and validation of an LC method for the determination of six corticosteroids, salicylic acid and parabens in different pharmaceutical formulations. Paper presented at IXth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Toussaint, B., Hubert, P., Tjaden, U. R., van der Greef, J., & Crommen, J. (10 February 2000). Enantiomeric Separation of Clenbuterol by Transient Isotachophoresis-Capillary Zone Electrophoresis-Uv Detection New Optimization Technique for Transient Isotachophoresis. Journal of Chromatography. A, 871 (1-2), 173-80. doi:10.1016/S0021-9673(99)00983-8
Peer Reviewed verified by ORBi

Chiap, P., Buraglia, B. M., Ceccato, A., Hubert, P., & Crommen, J. (10 February 2000). Automated Liquid Chromatographic Determination of Atenolol in Plasma Using Dialysis and Trace Enrichment on a Cation-Exchange Precolumn for Sample Handling. Journal of Chromatography. B, Biomedical Sciences and Applications, 739 (1), 205-17. doi:10.1016/S0378-4347(99)00518-6
Peer Reviewed verified by ORBi

Chiap, P., Evrard, B., Bimazubute, M. A., De Tullio, P., Hubert, P., Delattre, L., & Crommen, J. (10 February 2000). Determination of Albendazole and Its Main Metabolites in Ovine Plasma by Liquid Chromatography with Dialysis as an Integrated Sample Preparation Technique. Journal of Chromatography. A, 870 (1-2), 121-34. doi:10.1016/S0021-9673(99)00938-3
Peer Reviewed verified by ORBi

Toussaint, B., Gysler, J., Hubert, P., Tjaden, U. R., van der Greef, J., & Crommen, J. (February 2000). In-Line Concentration and Enantioseparation of Clenbuterol by Transient Isotachophoresis-Capillary Zone Electrophoresis-Uv Detection. Biomedical Chromatography: BMC, 14 (1), 32-3. doi:10.1002/(SICI)1099-0801(200002)14:1<32::AID-BMC960>3.0.CO;2-J
Peer Reviewed verified by ORBi

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (2000). Multivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis. Biomedical Chromatography: BMC, 14 (1), 10-1. doi:10.1002/(SICI)1099-0801(200002)14:1<10::AID-BMC947>3.0.CO;2-8
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., Boulanger, B., & Crommen, J. (2000). Plans d’expérience en biolanalyse : optimisation d’une méthode de dialyse pour le traitement d’échantillons plasmatiques préalable à leur analyse chromatographique. Paper presented at Journées du GMP, Bordeaux, France.

Toussaint, B., Pitti, C., Streel, B., Ceccato, A., Hubert, P., & Crommen, J. (2000). Quantitative analysis of N-acetylcysteine and its pharmacopeial impurities in a pharmaceutical formulation by LC-UV-MS. Poster session presented at 6th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-6), Brugge, Belgium.

Toussaint, B., Streel, B., Ceccato, A., Hubert, P., & Crommen, J. (2000). Determination of N-acetylcysteine and its metabolites in plasma by LC-MS-MS. Poster session presented at 6th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-6), Brugge, Belgium.

Toussaint, B., Streel, B., Ceccato, A., Hubert, P., & Crommen, J. (2000). Determination of 3-tert.butylamino-1,2-propanediol enantiomers by LC-MS-MS. Poster session presented at 6th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-6), Brugge, Belgium.

Bodart, P., Kabengera, C., Noirfalise, A., Hubert, P., & Angenot, L. (2000). Determination of Alpha-Solanine and Alpha-Chaconine in Potatoes by High-Performance Thin-Layer Chromatography/Densitometry. Journal of AOAC International, 83 (6, Nov-Dec), 1468-73. doi:10.1093/jaoac/83.6.1468
Peer Reviewed verified by ORBi

Crommen, J., Chiap, P., Fleischer, C. T., Boos, K. S., & Hubert, P. (2000). New trends in automated sample preparation coupled to LC for the determination of drugs in biological fluids. Paper presented at IXth International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2000), Basel, Switzerland.

Toussaint, B., Duchateau, A. L. L., Van der Wal, S., Hubert, P., & Crommen, J. (2000). Comparative evaluation of four detectors in the HPLC analysis of chiral non-aromatic alcohols. Paper presented at 9e Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Fillet, M., Abushoffa, A., Hubert, P., & Crommen, J. (2000). Model for selectivity optimizations by capillary electrophoresis using dual cyclodextrin systems. Paper presented at XIIIth International Symposium on High Performance Capillary Electrophoresis, Saarbrucken, Germany.

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2000). Objectives of pre-study validation and decision rules. Paper presented at AAPS Workshop on bioanalytical methods validation – A revisit with a decade of progress, Arlington, United States.

Fotsing, L., Fillet, M., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (2000). Determination of water-soluble vitamins and related compounds by capillary electrophoresis using a multivariate approach for method development. Poster session presented at XIIIth International Symposium on High Performance Capillary Electrophoresis, Saarbrucken, Germany.

Abushoffa, A., Fillet, M., Hubert, P., & Crommen, J. (2000). Separation of aminoglutethimide enantiomers using single and dual cyclodextrin systems in capillary electrophoresis. Paper presented at 9e Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Kabengera, C., Bodart, P., Hubert, P., Thunus, L., & Noirfalise, A. (2000). Determination of total arsenic in foods by HGAAS. Paper presented at 9e Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Hubert, P., Boulanger, B., Chiap, P., Dewé, W., & Crommen, J. (2000). Analyse statistique des résultats de validation de méthodes d’analyse chromatographiques. Paper presented at Les Journées du GMP, Bordeaux, France.

Crommen, J., Fillet, M., Abushoffa, A., & Hubert, P. (2000). The use of dual cyclodextrin systems for enantiomeric separations in capillary electrophoresis : is it the panacea ? Paper presented at XXIIIrd International Symposium on Capillary Chromatography, Riva del garda, Italy.

Crommen, J., Chiap, P., & Hubert, P. (2000). Recent developments in automted sample preparation coupled to liquid chromatography for bioanalytical applications. Paper presented at Vth International Lichrospher ADS User Meeting, Munich, Germany.

Crommen, J., Abushoffa, A., Fillet, M., & Hubert, P. (2000). Enantiomeric separation of drugs by capillary electrophoresis using dual cyclodextrin systems. Paper presented at EUFEPS 2000, Budapest, Hungary.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (2000). New strategy for the validation of chromatographic bioanalytical methods. STP Pharma Pratiques, 10 (1), 21-38.
Peer reviewed

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (2000). Example of application of the new strategy proposed for the validation of chromatographic bioanalytical methods. STP Pharma Pratiques, 10 (2), 79-101.
Peer reviewed

Chiap, P., Hubert, P., & Crommen, J. (2000). Techniques de préparation basées sur l'utilisation de membranes pour le traitement des échantillons biologiques préalable à leur analyse chromatographique. STP Pharma Pratiques, 10 (6), 361-374.
Peer reviewed

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods. Poster session presented at Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M. H., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods. Poster session presented at Chirality: Impact in Drug Design and Development, Braine l’Alleud, Belgium.

Bodart, P., Hubert, P., Angenot, L., & Noirfalise, A. (May 1999). Optimization of a high performance thin layer chromatography method to quantify solanines in potatoes. Paper presented at 8th Forum of Pharmaceutical Sciences, Spa, Belgium.

Bimazubute, M. A., Chiap, P., Marini Djang'Eing'A, R., Hubert, P., & Crommen, J. (May 1999). Development and validation of a LC method for the determination of bacitracin in a pharmaceutical dosage form. Paper presented at 8th Forum of Pharmaceutical Sciences, Spa, Belgium.

Bodart, P., Hubert, P., Kabengera, C., Angenot, L., & Noirfalise, A. (1999). Quantitative analysis of -solanine and -chaconine in potatoes by high performance thin layer chromatography. Paper presented at 8e Forum des Sciences Pharmaceutiques, Spa, Belgium.

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Elimination of adsorption effects in the analysis of water-soluble vitamins in pharmaceutical formulations by capillary electrophoresis. Journal of Chromatography. A, 853 (1-2), 391-401. doi:10.1016/S0021-9673(99)00524-5
Peer Reviewed verified by ORBi

Ceccato, A., Toussaint, B., Chiap, P., Hubert, P., & Crommen, J. (1999). Automated Sample Preparation Techniques for the Determination of Drug Enantiomers in Biological Fluids Using Liquid Chromatography with Chiral Stationary Phases. Enantiomer, 4 (3-4), 305-15.
Peer Reviewed verified by ORBi

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Study of adsorption effects in the analysis of pharmaceutical formulations by CE. Journal de Pharmacie de Belgique, 54.
Peer Reviewed verified by ORBi

Bodart, P., Hubert, P., Angenot, L., & Noirfalise, A. (1999). Optimization of a high performance thin layer chromatography method to quantify solanines in patatoes. Journal de Pharmacie de Belgique, 54.
Peer Reviewed verified by ORBi

Piette, V., Fillet, M., Hubert, P., & Crommen, J. (1999). Enantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives. Poster session presented at IIIrd Miniaturisation in Liquid Chromatography versus Capillary Electrophoresis Conference, Gent, Belgium.

Toussaint, B., Bergmann, J., Hubert, P., Tjaden, U. R., Van der Greef, J., & Crommen, J. (1999). Enantiomeric separation of clenbuterol by transient ITP-CE-MS. Poster session presented at HPLC’99, 23rd International Symposium on high performance liquid phase sepa-rations and related techniques, Grenade, Spain.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (1999). Determination of copper, iron and zinc in pharmaceutical formulations by capillary electrophoresis. Poster session presented at 23rd International Symposium on high performance liquid phase separations and related techniques, Grenade, Spain.

Hubert, P. (1999). Accréditation d'un laboratoire d'analyse: aspects réglementaires et pratiques.

Chiap, P., Hubert, P., Bimazubute, M., Evrard, B., Delattre, L., & Crommen, J. (1999). LC determination of albendazole and its main metabolites in ovine plasma using dialysis as integrated sample preparation technique. Poster session presented at XXIIIrd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Grenade, Spain.

Bimazubute, M., Chiap, P., Fotsing, L., Hubert, P., & Crommen, J. (1999). Method development and validation for the LC quantitative analysis of bacitracin in a pharmaceutical formulation. Poster session presented at XXIIIrd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Grenade, Spain.

Crommen, J., Chiap, P., Ceccato, A., & Hubert, P. (1999). Fully automated methods for the LC determination of drug enantiomers in plasma using precolumns with Restricted Access Material (RAM) for sample pretreatement. Paper presented at Internationales LiChrospher ADS Anwender Treffen, Munich, Germany.

Crommen, J., Fillet, M., Abushoffa, A., Fotsing, L., & Hubert, P. (1999). Design of dual cyclodextrin systems in capillary electrophoresis for selectivity optimisation in chiral analysis. Paper presented at 8th International Meeting on Recent Development in Pharmaceutical Analysis (RDPA’99), Rome, Italy.

Fillet, M., Chankvetadze, B., Hubert, P., & Crommen, J. (1999). Selectivity enhancement for enantiomeric separations in capillary electrophoresis using dual cyclodextrin systems. Paper presented at 23rd International Symposium on high performance liquid phase separations and related techniques, Grenade, Spain.

Crommen, J., Fillet, M., Abushoffa, A., Fotsing, L., & Hubert, P. (1999). Design of dual cyclodextrin systems in capillary electrophoresis for selectivity optimisation in enantiomeric separations. Paper presented at Balaton Symposium’99, Siofok, Hungary.

Chiap, P., Toussaint, B., Hubert, P., & Crommen, J. (1999). Automated LC determination of drugs and metabolites in plasma using dialysis and trace enrichment as on-line sample preparation techniques. Paper presented at 1st International Symposium on SBS, Separation in the Biosciences, Amsterdam, Netherlands.

Toussaint, B., Bergmann, J., Hubert, P., Tjaden, U. R., Van der Greef, J., & Crommen, J. (1999). In-line concentration and enantioseparation of clenbuterol by transient ITP-CE-UV. Poster session presented at IIIrd Miniaturisation in Liquid Chromatography versus Capillary Electrophoresis Conference, Gand, Belgium.

Crommen, J., Chiap, P., Toussaint, B., Ceccato, A., & Hubert, P. (1999). Développement et validation de méthodes entièrement automatisées pour le dosage de médicaments et de leurs métabolites dans les fluides biologiques. Paper presented at SEP’99 Techniques séparatives et couplages, Lyon, France.

Crommen, J., Fotsing, L., Fillet, M., Chiap, P., & Hubert, P. (1999). Method development and validation for the CE analysis of multi-vitamin formulations. Paper presented at Xth International Symposium on Pharmaceutical and Biomedical Analysis, Washington, United States.

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Studies on the variability of migration times observed in the analysis of pharmaceutical formulations by capillary electrophoresis. Paper presented at 8e Forum des Sciences Pharmaceutiques, Spa, Belgium.

Toussaint, B., Bergmann, J., Hubert, P., Tjaden, U. R., Van der Greef, J., & Crommen, J. (1999). MS compatible method for the preconcentration of clenbuterol enantiomers prior to enantiomeric separation using transient ITP-CZE-UV. Paper presented at 8e Forum des Sciences Pharmaceutiques, Spa, Belgium.

Crommen, J., Fillet, M., Fotsing, L., & Hubert, P. (1999). Method development strategies for enantiomeric separations by capillary electrophoresis using charged and neutral cyclodextrin derivatives as chiral selectors. Paper presented at IIIrd Miniaturisation in Liquid Chromatography versus Capillary Electrophoresis Conference, Gent, Belgium.

Chiap, P., Evrard, B., Bimazubute, M., De Tullio, P., Hubert, P., Delattre, L., & Crommen, J. (1999). On-line combinaison of dialysis with liquid chromatography for the automated determination of albendazole and its main metabolites in ovine plasma. Paper presented at VIIIème Forum des Sciences Pharmaceutiques, Spa, Belgium.

Piette, V., Fillet, M., Hubert, P., & Crommen, J. (1999). Enantiomeric separation of N-derivatised amino acids by non-aqueous capillary electrophoresis using cinchona alkaloids and derivatives as chiral selectors. Poster session presented at 23rd International Symposium on high performance liquid phase separations and related techniques, Grenade, Spain.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (1999). Multivariate optimisation approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis. Poster session presented at IIIrd Miniaturisation in Liquid Chromatography versus Capillary Electrophoresis Conference, Gand, Belgium.

Fotsing, L., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (1999). Elimination of adsorption effects in the analysis of pharmaceutical formulations by capillary electrophoresis. Poster session presented at XIIth International Symposium on High Performance Capillary Electrophoresis, Palm Springs, United States.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1999). Effective resolution of racemic pirlindole at the preparative scale. Chirality, 11, 261-266. doi:10.1002/(SICI)1520-636X(1999)11:4<261::AID-CHIR1>3.0.CO;2-S
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., Boulanger, B., & Crommen, J. (1999). Validation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol. Analytica Chimica Acta, 391 (2), 227-238. doi:10.1016/S0003-2670(99)00117-8
Peer Reviewed verified by ORBi

Hubert, P., Ceccato, A., Chiap, P., Toussaint, B., & Crommen, J. (1999). Préparation des échantillons d'origine biologique préalable à leur analyse chromatographique. STP Pharma Pratiques, 9 (2), 160-180.
Peer reviewed

Hubert, P., Chiap, P., Crommen, J., Boulanger, B., Chapuzet, E., Mercier, N., Bervoas-Martin, S., Chevalier, P., Grandjean, D., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1999). The SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory. Analytica Chimica Acta, 391 (2), 135-148. doi:10.1016/S0003-2670(99)00106-3
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (December 1998). Enantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases. Journal of Pharmaceutical and Biomedical Analysis, 18 (4-5), 605-14. doi:10.1016/S0731-7085(98)00213-1
Peer Reviewed verified by ORBi

Fillet, M., Hubert, P., & Crommen, J. (November 1998). Method Development Strategies for the Enantioseparation of Drugs by Capillary Electrophoresis Using Cyclodextrins as Chiral Additives. Electrophoresis, 19 (16-17), 2834-40. doi:10.1002/elps.1150191608
Peer Reviewed verified by ORBi

Ceccato, A., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (11 September 1998). Simultaneous Determination of Methylphenobarbital Enantiomers and Phenobarbital in Human Plasma by on-Line Coupling of an Achiral Precolumn to a Chiral Liquid Chromatographic Column. Journal of Chromatography. A, 819 (1-2), 143-53. doi:10.1016/S0021-9673(98)00547-0
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (01 September 1998). Simultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 17 (6-7), 1071-9. doi:10.1016/S0731-7085(98)00073-9
Peer Reviewed verified by ORBi

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Effective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration. Poster session presented at XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration. Poster session presented at Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

De Tullio, P., Ceccato, A., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (16 January 1998). Séparation énantiomérique du pirlindole à l’échelle préparative. Poster session presented at Journées Jeunes Chercheurs, Paris, France.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration. European Journal of Pharmaceutical Sciences, suppl.1, 37.
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole. Journal de Pharmacie de Belgique, 53, 60.
Peer Reviewed verified by ORBi

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindole. Journal de Pharmacie de Belgique, 53, 55.
Peer Reviewed verified by ORBi

De Tullio, P., Felikidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindol, journées franco-belges de pharmacochimie. Journal de Pharmacie de Belgique, 53, 55.
Peer Reviewed verified by ORBi

Fillet, M., Fotsing, L., Piette, V., Hubert, P., & Crommen, J. (1998). Method development strategies for the rapid enantioseparation of drugs by capillary electrophoresis using cyclodextrins as chiral additives. Journal de Pharmacie de Belgique, 53, 184.
Peer Reviewed verified by ORBi

Toussaint, B., Ceccato, A., Hubert, P., & Crommen, J. (1998). Quantitative analysis of l-lysine n-acetylcysteinate and related compounds by LC-MS. Journal de Pharmacie de Belgique, 53, 260.
Peer Reviewed verified by ORBi

Fotsing, L., Fillet, M., Hubert, P., & Crommen, J. (1998). Quantitative analysis of folic acid in a pharmaceutical formulation by capillary electrophoresis. Journal de Pharmacie de Belgique, 53, 185.
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Stachow, M., Felikidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindol. Journal de Pharmacie de Belgique, 53, 60.
Peer Reviewed verified by ORBi

Boulanger, B., Caliaro, G., Dewé, W., Engel, M., Vandenhende, M., & Hubert, P. (1998). Finding rugged pareto optimal solutions in HPLC by means of models : simple is efficient. Journal de Pharmacie de Belgique, 53, 162.
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (1998). Determination of the enantiomeric purity of pirlindole by liquid chromatography using a cellulose based chiral stationary phase. Journal de Pharmacie de Belgique, 53, 169.
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (1998). Liquid chromatographic separation of pirlindole enantiomers using different types of chiral stationary phases. Journal de Pharmacie de Belgique, 53, 168.
Peer Reviewed verified by ORBi

Chiap, P., Planck, I., Evrard, B., Hubert, P., Delattre, L., & Crommen, J. (1998). Automated determination of acyclovir in human plasma using solid phase extraction and liquid chromatography. Journal de Pharmacie de Belgique, 53, 172.
Peer Reviewed verified by ORBi

Fillet, M., Fotsing, L., Hubert, P., & Crommen, J. (1998). Selectivity improvement in the capillary electrophoretic enantioseparation of uncharged compounds by use of mixtures of charged and neutral cyclodextrins. Poster session presented at 10th International Symposium on Chiral Discrimination, Vienne, Austria.

Toussaint, B., Ceccato, A., Hubert, P., & Crommen, J. (1998). Determination of l-lysine N-acetylcysteinate, its mono- and dimeric related compounds by LC-MS-MS. Poster session presented at 5th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers, Brugge, Belgium.

Chiap, P., Boulanger, B., Ceccato, A., Hubert, P., & Crommen, J. (1998). On-line coupling of dialysis to liquid chromatography for the automated determination of some local anaesthetics in human plasma. Journal de Pharmacie de Belgique, 53, 172.
Peer Reviewed verified by ORBi

Chiap, P., Boulanger, B., Bimazubute, M., Hubert, P., & Crommen, J. (1998). Validation of an automated method for the LC determination of atenolol in plasma : application of a new validation strategy. Journal de Pharmacie de Belgique, 53, 171.
Peer Reviewed verified by ORBi

Streel, B., Ceccato, A., Sibenaler, R., Zimmer, C., & Hubert, P. (1998). Simultaneous determination of nifedipine and its metabolite in human plasma by LC/MS/MS using APCI interface. Poster session presented at 5th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers, Brugge, Belgium.

Fillet, M., Fotsing, L., Schomburg, G., Hubert, P., & Crommen, J. (1998). Enantioseparation of Acidic Drugs by Capillary Electrophoresis Using Dual Systems with Mixtures of Charged and Neutral Cyclodextrins. Biomedical Chromatography: BMC, 12 (3, May-Jun), 131-2. doi:10.1002/(SICI)1099-0801(199805/06)12:3<131::AID-BMC779>3.0.CO;2-P
Peer Reviewed verified by ORBi

Hubert, P., & Boulanger, B. (1998). Validation des méthodes d’analyse des médicaments dans les milieux biologiques.

Fillet, M., Fotsing, L., Hubert, P., & Crommen, J. (1998). Enantioseparation of uncharged compounds by capillary electrophoresis using mixtures of anionic and neutral -cyclodextrin derivatives. Poster session presented at XIth International Symposium on High Performance Capillary Electrophoresis, Orlando, United States.

Gora, R., Ceccato, A., Toussaint, B., Hubert, P., & Crommen, J. (1998). Automated liquid chromatographic analysis of pirlindole enantiomers in plasma using a precolumn with restricted access material in a column switching system. Paper presented at 3rd course on chiral chemistry, Project Tempus S-JEP-09101-95 « New Curriculum in Chiral Chemistry », Bratislava, Slovakia.

Delporte, J.-P., Chenoix, P., & Hubert, P. (1998). Study of external contamination of the primary packaging of 5-Fluorouracil RTU solutions commercially available on the Belgian Market. Paper presented at Congress of the European Hospital Pharmacy (E.H.P.), Nice, France.

Crommen, J., Ceccato, A., Fillet, M., Chiap, P., Toussaint, B., & Hubert, P. (1998). Method development and validation for the individual quantitation of drug en-antiomers using liquid chromatography or capillary electrophoresis. Paper presented at 3rd course on chiral chemistry, Project Tempus S-JEP-09101-95 « New Curriculum in Chiral Chemistry ».

Hubert, P., Boulanger, B., & Veuthey, J. L. (1998). validation de méthodes analytiques. Paper presented at Professional training in analytical chemistry, Eurocours Leonardo Da Vinci, Genève, Switzerland.

Crommen, J., Chiap, P., Toussaint, B., Ceccato, A., & Hubert, P. (1998). Sample preparation strategies for the fully automated determination of drugs and metabolites in biologicals fluids. Paper presented at XIV Convegno nazionale, divisione di chimica farmaceutica, Società Chimica Italiana, Salsomaggiore Terme -–Parma, Italy.

Toussaint, B., Hubert, P., Hofte, B., Moonen, G., Tjaden, U. R., Van der Greef, J., & Crommen, J. (1998). Struture elucidation of a neurotoxic astroglia-released factor by liquid chromatography and mass spectrometric detection. Poster session presented at 15th Symposium on liquid chromatography / Mass spectrometry, Montreux, Switzerland.

Fillet, M., Fotsing, L., Hubert, P., & Crommen, J. (1998). Stereoselective determination of s-naproxen in tablets by capillary electrophoresis. Journal de Pharmacie de Belgique, 53, 185.
Peer Reviewed verified by ORBi

Toussaint, B., Hubert, P., Ceccato, A., Hurlet, V., Rigo, J. M., COUCKE, P., Moonen, G., & Crommen, J. (1998). Vizualization and structural analysis of a neurotoxic astroglia-released factor by liquid chromatography using fluorescence and mass spectrometric detection. Poster session presented at Bioforum, Liège, Belgium.

De Tullio, P., Felekidis, A., Pirotte, B., Liégeois, J.-F., Stachow, M., Delarge, J., Ceccato, A., Hubert, P., Crommen, J., & Geczy, J. (1998). First preparative enantiomer resolution of pirlindole, a potent antidepressant drug. Helvetica Chimica Acta, 81, 539-547. doi:10.1002/hlca.19980810307
Peer Reviewed verified by ORBi

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorge, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1998). Méthodes chromatographiques de dosage dans les milieux biologiques : exemple d'application de la stratégie de validation - Rapport d'une commission SFSTP. STP Pharma Pratiques, 8 (2), 81-107.
Peer reviewed

Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (26 September 1997). Automated Determination of Tramadol Enantiomers in Human Plasma Using Solid-Phase Extraction in Combination with Chiral Liquid Chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications, 698 (1-2), 161-70. doi:10.1016/S0378-4347(97)00267-3
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (September 1997). Simultaneous determination of pirlindole enantiomers and dehydropirlindole by liquid chromatography using a cellulose based chiral stationary phase. Poster session presented at 7th Meeting on Recent Developments in Pharmaceutical Analysis, Ile d'Elbe, Italy.

Ceccato, A., Toussaint, B., Chiap, P., Hubert, P., & Crommen, J. (June 1997). Enantioselective Determination of Oxprenolol in Human Plasma Using Dialysis Coupled on-Line to Reversed-Phase Chiral Liquid Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 15 (9-10), 1365-74. doi:10.1016/S0731-7085(96)01965-6
Peer Reviewed verified by ORBi

Fotsing, L., Fillet, M., Bechet, I., Hubert, P., & Crommen, J. (May 1997). Determination of Six Water-Soluble Vitamins in a Pharmaceutical Formulation by Capillary Electrophoresis. Journal of Pharmaceutical and Biomedical Analysis, 15 (8), 1113-23. doi:10.1016/S0731-7085(96)02010-9
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (May 1997). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole. Poster session presented at Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Cegzy, J., & Delarge, J. (May 1997). Résolution préparative du pirlindole. Poster session presented at Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Fillet, M., Hubert, P., & Crommen, J. (1997). Enantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged beta-cyclodextrins as chiral additives. Electrophoresis, 18 (6), 1013-8. doi:10.1002/elps.1150180625
Peer Reviewed verified by ORBi

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1997). Méthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation. Paper presented at XXIXth International seminar of SFSTP, Validation: quality enhancer, economic necessity, Montpellier, France.

Toussaint, B., Ceccato, A., Maes, P., Hubert, P., & Crommen, J. (1997). Determination of N-acetylcysteine and its potential degradation products by LC/APCI+/MS/MS. Paper presented at VIth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Ceccato, A., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (1997). LC determination of mephobarbital enantiomers and phenobarbital in plasma using a precolumn with restricted access sorbent for sample clean-up. Poster session presented at HPLC’ 97, Birmingham, United Kingdom.

Boulanger, B., Ceccato, A., Chiap, P., & Hubert, P. (1997). Selecting Derringer’s desirability functions that guarantee Pareto optimality : an application to the optimization of a liquid chromatography separation. Poster session presented at HPLC 97, Birmingham, United Kingdom.

Fillet, M., Bechet, I., Schomburg, G., Hubert, P., & Crommen, J. (1997). The use of mixtures of anaionic and uncharged cyclodextrins for the enantiomeric separation of acidic drugs by capillary electrophoresis. Poster session presented at IXth International Symposium on High Performance Capillary Electrophoresis, Anaheim, United States.

Hubert, P., & Boulanger, B. (1997). Validation des méthodes d’analyse des médicaments dans les milieux biologiques.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (1997). Enantiomeric separation of pirlindole enantiomers and dehydroprilindole by chrial liquid chromatography. Poster session presented at VIIth meeting on recent developments in pharmaceutical analysis.

Chiap, P., Miralles, B., Ceccato, A., Hubert, P., & Crommen, J. (1997). Automated liquid chromatographic determination of atenolol in plasma using dialysis and trace enrichment on a cation exchange precolumn for sample pre-treatement. Poster session presented at VIIth meeting on recent developments in pharmaceutical analysis.

Fillet, M., Bechet, I., Ceccato, A., Hubert, P., & Crommen, J. (1997). Enantiomeric separation of basic drugs by CZE using charged and uncharged cyclodextrins as chiral selectors. Poster session presented at VIIth International Symposium on High Performance Capillary Electrophoresis, Wurzburg, Germany.

Fillet, M., Fotsing, L., Hubert, P., & Crommen, J. (1997). Chiral separation of acidic drugs by capillary electrophoresis using charged and uncharged cyclodextrins as buffer additives. Paper presented at VIth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1997). Coupled-column LC analysis of mephobarbital enantiomers in plasma using restricted access packing material in the precolumn. Paper presented at VIth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1997). Automated determination of tramadol enantiomers in plasma using solid-phase extraction and chiral liquid chromatography. Poster session presented at VIIIth International Symposium on Pharmaceutical and Biomedical Analysis, Orlando, United States.

Crommen, J., Fillet, M., Gotti, R., Fotsing, L., & Hubert, P. (1997). Resolution enhancement in the CE separation of drug enantiomers by use of mixtures of charged and neutral cyclodextrins. Paper presented at VIIIth International Symposium on Pharmaceutical and Biomedical Analysis, Orlando, United States.

Chiap, P., Ceccato, A., Miralles, B., Boulanger, B., Hubert, P., & Crommen, J. (1997). On-line combination of dialysis with trace enrichment on a cation-exchange precolumn for the automated LC determination of sotalol in plasma. Poster session presented at HPLC 97, Birmingham, United Kingdom.

Chiap, P., Hubert, P., Ceccato, A., & Crommen, J. (1997). Automated LC determination of molsidomine and two of its metabolites in plasma using solid phase extraction as sample pretreatment. Poster session presented at HPLC’ 97, Birmingham, United Kingdom.

Fillet, M., Schomburg, G., Hubert, P., & Crommen, J. (1997). Enantioseparation of acidic drugs by capillary electrophoresis using dual systems with mixtures of charged and neutral cyclodextrins as chrial selectors.

Fillet, M., Schomburg, G., Hubert, P., De Graeve, J., & Crommen, J. (1997). Dual cyclodextrin systems for the enantioseparation of acidic drugs by capillary zone electrophoresis. Poster session presented at HPLC 97, Birmingham, United Kingdom.

Fotsing, L., Fillet, M., Hubert, P., & Crommen, J. (1997). Quantitative analysis of six water-soluble vitamins in a pharmaceutical formulation by capillary electrophoresis. Poster session presented at HPLC 97, Birmingham, United Kingdom.

Toussaint, B., Ceccato, A., Hubert, P., & Crommen, J. (1997). Determination of N-acetylcysteine and its potential degradation products by LC/MS/MS. Poster session presented at HPLC 97, Birmingham, United Kingdom.

Crommen, J., Fillet, M., Schomburg, G., Fotsing, L., & Hubert, P. (1997). Influence of dynamic and permanent surface modification on the performance of CE separations of small molécules. Paper presented at Symposium on High Performance Capillary Electrophoresis, Kyoto, Japan.

Crommen, J., Ceccato, A., Toussaint, B., Chiap, P., & Hubert, P. (1997). Fully automated systems for the liquid chromatographic determination of drug enantiomers in biological fluids. Paper presented at VIIth meeting on recent developments in pharmaceutical analysis.

Crommen, J., Fillet, M., Gotti, R., & Hubert, P. (1997). Method development strategies for the chiral analysis of drugs by CE using anionic and uncharged cyclodextrin additives. Paper presented at HPLC’ 97, Birmingham, United Kingdom.

Hubert, P., & Boulanger, B. (1997). Validation des méthodes d’analyse des médicaments dans les milieux biologiques.

Crommen, J., Fillet, M., Ceccato, A., & Hubert, P. (1997). Enantiomeric resolution of drugs by capillary electrophoresis. Paper presented at 57th FIP World Congress 1997, Vancouver, Canada.

Hubert, P., Hurlet, V., Rigo, J.-M., Coucke, P., Moonen, G., & Crommen, J. (1997). Fluorescence Detection of a Neurotoxic Astroglia-Released Factor Using Gradient Liquid Chromatography after Precolumn Derivatization. Biomedical Chromatography: BMC, 11 (2, Mar-Apr), 93-5. doi:10.1002/(SICI)1099-0801(199703)11:2<93::AID-BMC656>3.0.CO;2-J
Peer Reviewed verified by ORBi

Hubert, P., Ceccato, A., Hurlet, V., Rigo, J.-M., Coucke, P., Moonen, G., & Crommen, J. (1997). Automated determination of tramadol enantiomers in plasma using solid-phase extraction and chiral liquid chromatography. Poster session presented at Second meeting of the Belgian Society of Neuroscience, Brussels, Belgium.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorge, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1997). Méthodes chromatographiques de dosage dans les milieux biologiques : stratégie de validation - Rapport d'une commission SFSTP. STP Pharma Pratiques, 7 (3), 169-194.
Peer reviewed

Ceccato, A., Chiap, P., Hubert, P., Toussaint, B., & Crommen, J. (25 October 1996). Automated Determination of Verapamil and Norverapamil in Human Plasma with on-Line Coupling of Dialysis to High-Performance Liquid Chromatography and Fluorometric Detection. Journal of Chromatography. A, 750 (1-2), 351-60. doi:10.1016/0021-9673(96)00471-2
Peer Reviewed verified by ORBi

Fillet, M., Bechet, I., Hubert, P., & Crommen, J. (June 1996). Resolution Improvement by Use of Carboxymethyl-Beta-Cyclodextrin as Chiral Additive for the Enantiomeric Separation of Basic Drugs by Capillary Electrophoresis. Journal of Pharmaceutical and Biomedical Analysis, 14 (8-10), 1107-14. doi:10.1016/S0731-7085(95)01756-9
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., Chiap, P., Toussaint, B., & Crommen, J. (1996). On-line dialysis coupled to liquid chromatography for the automated determination of verapamil and its demethylated metabolite in plasma, chapitre "biomedical analysis with hyphenated chromatography". In Hyphenated techniques in chromatography and hyphenated chromatographic analysers. K.V.C.V.

Fillet, M., Bechet, I., Schomburg, G., Hubert, P., & Crommen, J. (1996). Enantiomeric separation of acidic and basic drugs by capillary electrophoresis using neutral and anionic cyclodextrins. Journal de Pharmacie de Belgique, 51, 110.
Peer Reviewed verified by ORBi

Bechet, I., Fillet, M., Hubert, P., & Crommen, J. (1996). Influence of organic modifiers and cyclodextrins on the CZE separation of non-steroidal anti-inflammatory drugs. Poster session presented at VIIIth International Symposium on High Performance Capillary Electrophoresis, Orlando, United States.

Crommen, J., Fillet, M., Bechet, I., Schomburg, G., & Hubert, P. (1996). Applications of cyclodextrin mediated capillary electrophoresis to the chiral analysis of drugs and related compounds. Paper presented at 10th International Symposium on Advances and Applications of Chromatography in Industry, Bratislava, Slovakia.

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1996). Méthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation. Paper presented at Symposium de la SFSTP, Paris, France.

Ceccato, A., Hubert, P., Chiap, P., Toussaint, B., & Crommen, J. (1996). On-line dialysis coupled to liquid chromatography for the automated determination of verapamil and its demethylated metabolite in plasma. Paper presented at 4th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyses, Bruges, Belgium.

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1996). SFSTP guide on validation of bioanalytical methods : a proposal. Paper presented at Drug Information Association workshop, Statistical methodology in non-clinical and toxicological studies, Bruges, Belgium.

Ceccato, A., Toussaint, B., Miralles, B., Chiap, P., Hubert, P., & Crommen, J. (1996). On-line dialysis coupled to liquid chromatography for the automated determination of oxprenolol enantiomers in human plasma. Poster session presented at VIIth International Symposium on Pharmaceutical and Biomedical Analysis, Osaka, Japan.

Hubert, P., Chiap, P., & Crommen, J. (1996). Strategy for bioanalytical method validation : approach of SFSTP commission. Paper presented at KVCV Chemometrics Symposium ‘96, Louvain, Belgium.

Fillet, M., Bechet, I., Schomburg, G., Hubert, P., & Crommen, J. (1996). Enhanced resolution in the capillary electrophoresis of drug enantiomers by use of charged cyclodextrin derivatives and dynamically or permanently coated capillaries. Paper presented at HPLC’ 96, San Francisco, United States.

Hubert, P., Chiap, P., & Crommen, J. (1996). Method validation in a European context, Chromatografische informatie in cyberspace en in andere moderne media. Paper presented at KVCV Symposium, Bruxelles, Belgium.

Fillet, M., Bechet, I., Schomburg, G., Hubert, P., & Crommen, J. (1996). Enantiomeric separation of acidic drugs by capillary electrophoresis using mixtures of anionic and uncharged cyclodextrins as chiral additives. Paper presented at Xth International Symposium on Capillary Electrophoresis and Isotachophoresis, Prague, Czechia.

Crommen, J., Fillet, M., Bechet, I., & Hubert, P. (1996). Chiral separations of drugs by capillary electrophoresis using neutral and charged cyclodextrin derivatives. Paper presented at VIIth International Symposium on Pharmaceutical and Biomedical Analysis, Osaka, Japan.

Ceccato, A., Toussaint, B., Chiap, P., Hubert, P., & Crommen, J. (1996). LC determination of oxprenolol enantiomers in human plasma using dialysis as on-line sample preparation technique. Journal de Pharmacie de Belgique, 51, 106.
Peer Reviewed verified by ORBi

Fotsing, L., Bechet, I., Fillet, M., Hubert, P., & Crommen, J. (1996). Determination of water-soluble vitamins by capillary zone electrophoresis. Journal de Pharmacie de Belgique, 51, 110.
Peer Reviewed verified by ORBi

Crommen, J., Chiap, P., Ceccato, A., & Hubert, P. (1996). Analytical technologies and tolls for drug purity testing. Paper presented at IIIrd EUFEPS Conference, Nuremberg, Germany.

Hubert, P., Hurlet, V., Rigo, J.-M., Coucke, P., Moonen, G., & Crommen, J. (1996). Fluorescence detection of a neurotoxic astroglia-released factor after precol-umn derivatization and gradient liquid chromatography. Poster session presented at VIIth International symposium on liminescence spectrometry in biomedical analysis, Nice, France.

Bechet, I., Hubert, P., Crommen, J., & Fillet, M. (April 1995). Quantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis. Journal of Pharmaceutical and Biomedical Analysis, 13 (4-5), 497-503. doi:10.1016/0731-7085(95)01339-M
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., Ceccato, A., Toussaint, B., & Crommen, J. (1995). Comparison of solid-phase extraction and dialysis as on-line sample preparation procedures for the automated HPLC determination of verapamil and norverapamil in human plasma. Journal de Pharmacie de Belgique, 50, 321.
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., Ceccato, A., Fillet, M., & Crommen, J. (1995). Automated HPLC analysis of molsidomine and two of its metabolites in human plasma using solid phase extraction as sample preparation. Journal de Pharmacie de Belgique, 50, 320.
Peer Reviewed verified by ORBi

Toussaint, B., Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1995). On-line combination of dialysis and liquid chromatography for the automated determination of oxprenolol in human plasma. Journal de Pharmacie de Belgique, 50, 403.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Ceccato, A., Fillet, M., & Crommen, J. (1995). Automated determination of acetylsalicylic, salicylic and salicyluric acids in human plasma using solid-phase extraction and HPLC. Journal de Pharmacie de Belgique, 50, 341.
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., Streel, B., Bechet, I., & Crommen, J. (1995). Enantiomeric separaiton of sotalol and other B-blockers on a chiral-AGP column using aliphatic carboxylic acids as ionic modifiers. Journal de Pharmacie de Belgique, 50, 319.
Peer Reviewed verified by ORBi

Fotsing, L., Fillet, M., Bechet, I., Hubert, P., & Crommen, J. (1995). Comparison of Ce and LC methods for the determination of B vitamins in pharmaceutical dosage forms. Journal de Pharmacie de Belgique, 50, 332.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Ceccato, A., Bechet, I., & Crommen, J. (1995). Automated determination of camazepam in human plasma by solid phase extraction coupled to HPLC. Journal de Pharmacie de Belgique, 50, 341.
Peer Reviewed verified by ORBi

Streel, B., Zimmer, C., Sibenaler-Dechamps, R., Hubert, P., & Crommen, J. (1995). HPLC determination of fenofibric acid in human plasma using automated solid phase extraction as sample preparation. Journal de Pharmacie de Belgique, 50, 399.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1995). Validation of bioanalytical methods. Journal de Pharmacie de Belgique, 50, 290.
Peer Reviewed verified by ORBi

Fillet, M., Schomburg, G., Bechet, I., Hubert, P., & Crommen, J. (1995). Enantiomeric separation of basic drugs by cyclodextrin modified capillary electrophoresis using poly(vinyl alcohol) coated fused silica capillaries. Journal de Pharmacie de Belgique, 50, 331.
Peer Reviewed verified by ORBi

Streel, B., Hubert, P., Ceccato, A., Chiap, P., & Crommen, J. (1995). Determination of phenothiazines by microcolumn liquid chromatography using injection-generated gradient techniques for sample enrichment. Journal de Pharmacie de Belgique, 50, 398.
Peer Reviewed verified by ORBi

Bechet, I., Fillet, M., Fotsing, L., Hubert, P., & Crommen, J. (1995). Influence of organic modifiers and complexing agents on the separation of non-steroidal anti-inflammatory drugs by capillary zone electrophoresis. Journal de Pharmacie de Belgique, 50, 305.
Peer Reviewed verified by ORBi

Crommen, J., Fillet, M., Bechet, I., & Hubert, P. (1995). Enantiomeric separations by capillary electrophoresis applications in pharmaceutical, biomedical and environmental analysis, chapitre #L-7. In B. Buszewski, New analytical methods for environmental control and monitoring. Torun, Poland: Pozkal.

Fillet, M., Bechet, I., Schomburg, G., Hubert, P., & Crommen, J. (1995). Enantiomeric separations of basic drugs by capillary electrophoresis using derivatized cyclodextrins and dynamically or permanently modified capillaries. Poster session presented at VIIth International Symposium on Chiral Discrimination, Jerusalem, Israel.

Crommen, J., Fillet, M., Bechet, I., & Hubert, P. (1995). Enantiomeric separations by capillary electrophoresis applications in pharmaceutical, biomedical and environmental analysis. Paper presented at IInd National Chromatographic Seminar on Modern Analytical Methods in Control and Monitoring of the Environment, Torun, Poland.

Fillet, M., Bechet, I., Ceccato, A., Hubert, P., & Crommen, J. (1995). Enantioseparations of basic compounds by capillary electrophoresis using neutral and anionic cyclodextrins. Poster session presented at VIth International Symposium on Pharmaceutical and Biomedical Analysis, Saint Louis, United States.

Fillet, M., Bechet, I., Chiap, P., Hubert, P., & Crommen, J. (1995). Enantiomeric purity of propranolol by cyclodextrin modified capillary electrophoresis. Poster session presented at VIth International Symposium on Chiral Discrimination, Saint Louis, United States.

Bechet, I., Fillet, M., Hubert, P., & Crommen, J. (1995). Improvement of a chiral resolution in capillary zone electrophoresis by use of cyclodextrin additives. Paper presented at Symposium «Miniaturisering in vloeistofchromatografie versus capillaire elektroforese», Gand, Belgium.

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1995). Automated solid-phase extraction coupled to HPLC for the determination of drugs in biological fluids. Pharmacy World and Science, 17, 5.
Peer Reviewed verified by ORBi

Evrard, B., Hubert, P., Chiap, P., Crommen, J., & Delattre, L. (1995). A fully automated HPLC method for pharmacokinetic studies on a long-acting sulfamethazine veterinary bolus. Journal de Pharmacie de Belgique, 50, 328.
Peer Reviewed verified by ORBi

Hubert, P. (1995). Automated determination of drugs in ibological fluids using solid-phase extraction coupled to HPLC. Dissertation abstracts international.
Peer reviewed

Ceccato, A., Hubert, P., Toussaint, B., Chiap, P., & Crommen, J. (1995). Automated determination of verapamil and norverapamil in human plasma by high performance chromatography using dialysis as on-line sample preparation technique. Poster session presented at XIXth International Symposium on Column Liquid Chromatography and Related Techniques, Innsbruck, Austria.

Streel, B., Hubert, P., Ceccato, A., Chiap, P., & Crommen, J. (1995). Injection-generated solvent and pH gradients for sample enrichment on injection of large volumes in microcolumn liquid chromatography. Poster session presented at Symposium «Miniaturisering in vloeistofchromatografie versus capillaire elektroforese», Gand, Belgium.

Hubert, P., Chiap, P., Ceccato, A., Streel, B., & Crommen, J. (1995). Determination of several benzodiazepines in plasma using automated solid-phase extraction coupled to high performance chromatography. Poster session presented at XIXth International Symposium on Column Liquid Chromatography and Related Techniques, Innsbruck, Austria.

Bechet, I., Fillet, M., Fotsing, L., Hubert, P., & Crommen, J. (1995). CZE separation of basic and acidic drug by use of cyclodextrin additives. Poster session presented at VIIth International Symposium on High Performance Capillary Electrophoresis, Wurzburg, Germany.

Evrard, B., Hubert, P., Chiap, P., Crommen, J., & Delattre, L. (1995). A fully automated HPLC method for pharmacokinetic studies on a long-acting sulfamethazine veterinary bolus. Paper presented at 5th International Symposium on Drug Analysis, Leuven, Belgium.

Streel, B., Ceccato, A., Chiap, P., Hubert, P., & Crommen, J. (1995). Injection-generated solvent and pH gradients for sample enrichment on injection of large volumes in microclumn liquid chromatography. Biomedical Chromatography: BMC, 9, 254-256.
Peer Reviewed verified by ORBi

Evrard, B., Delahaut, P., Hubert, P., Crommen, J., & Delattre, L. (1995). Biopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs. Journal of Controlled Release, 35, 107-115. doi:10.1016/0168-3659(95)00025-4
Peer Reviewed verified by ORBi

Bechet, I., Fillet, M., Hubert, P., & Crommen, J. (October 1994). Determination of Benzodiazepines by Micellar Electrokinetic Chromatography. Electrophoresis, 15 (10), 1316-21. doi:10.1002/elps.11501501200
Peer Reviewed verified by ORBi

Bechet, I., Paques, P., Fillet, M., Hubert, P., & Crommen, J. (June 1994). Chiral Separation of Basic Drugs by Capillary Zone Electrophoresis with Cyclodextrin Additives. Electrophoresis, 15 (6), 818-23. doi:10.1002/elps.11501501115
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Moors, M., Bourguignon, B., Massart, D. L., & Crommen, J. (08 April 1994). Knowledge-Based System for the Automated Solid-Phase Extraction of Basic Drugs from Plasma Coupled with Their Liquid Chromatographic Determination. Application to the Biodetermination of Beta-Receptor Blocking Agents. Journal of Chromatography. A, 665 (1), 87-99. doi:10.1016/0021-9673(94)87035-7
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., & Crommen, J. (1994). Development of an automated solid phase extraction method coupled to HPLC for the determination of some benzodiazepines in plasma by use of a knowledge-based system. Journal de Pharmacie de Belgique, 49, 61.
Peer Reviewed verified by ORBi

Bechet, I., Fillet, M., Hubert, P., & Crommen, J. (1994). Quantitative analysis of B-adrenergic blocking agents by capillary zone electrophoresis. Journal de Pharmacie de Belgique, 49, 60.
Peer Reviewed verified by ORBi

Moors, M., Bourguignon, B., Massart, D. L., Hubert, P., Chiap, P., & Crommen, J. (1994). A knowledge-based system for developping solid-phase extraction methods with the ASPEC system, chapitre #D-3. In E. Reid, H. M. Hill, & I. D. Wilson, Biofluid and tissue analysis for drugs, including hypolipidaemics. Cambridge, United Kingdom: Royal Society of Chemistry.

Chiap, P., Hubert, P., & Crommen, J. (1994). HPLC determination of some -adrenergic blocking agents in plasma using automated solid-phase extraction and fluorometric detection. Poster session presented at VIth International Symposium on Luminescence Spectrometry in Biomedical Analysis, Bruges, Belgium.

Bechet, I., Paques, P., Fillet, M., Hubert, P., & Crommen, J. (1994). Determination of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis. Poster session presented at VIth International Symposium on High Performance Capillary Electrophoresis, San Francisco, United States.

Crommen, J., Fillet, M., Bechet, I., Ceccato, A., & Hubert, P. (1994). Chiral separations of basic drugs in capillary electrophoresis using cyclodextrin derivatives as chiral selectors. Paper presented at Vth International Symposium on Chiral Discrimination, Stockholm, Sweden.

Crommen, J., Bechet, I., Fillet, M., & Hubert, P. (1994). Chiral and achiral separations of basic drugs in capillary electrophoresis using cyclodextrin additives. Paper presented at IXth International Symposium on Capillary Electrophoresis, Budapest, Hungary.

Crommen, J., Bechet, I., Fillet, M., & Hubert, P. (1994). Determination of acidic and basic drugs by capillary zone electrophoresis. Paper presented at Vth International Symposium on Pharmaceutical and Biomedical Analysis, Stockholm, Sweden.

Crommen, J., Bechet, I., Fillet, M., & Hubert, P. (1994). Drug quality control by capillary electrophoresis. Paper presented at XIth Slovak Conference on Chromatographic methods and their utilization for human health, Stara Lesna, Slovakia.

Fillet, M., Bechet, I., Chiap, P., Hubert, P., & Crommen, J. (1994). Enantiomeric purity determination of propranolol enantiomers by capillary electrophoresis. Poster session presented at IXth International Symposium on Capillary Electrophoresis, Budapest, Hungary.

Hubert, P. (1994). Dosage automatisé de médicaments dans les milieux biologiques par extraction liquide-solide associée à la chromatographie liquide haute performance. Unpublished doctoral thesis, ULiège - Université de Liège.
Jury: Crommen, J. (Promotor).

Hubert, P., Chiap, P., Evrard, B., Delattre, L., & Crommen, J. (08 December 1993). Fully Automated Determination of Sulfamethazine in Ovine Plasma Using Solid-Phase Extraction on Disposable Cartridges and Liquid Chromatography. Journal of Chromatography. A, 622 (1), 53-60. doi:10.1016/0378-4347(93)80249-4
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., Streel, B., Bechet, I., & Crommen, J. (1993). HPLC enantiomeric separation of B-blocking drugs using an alpha 1-acid glycoprotein column. Journal de Pharmacie de Belgique, 48, 113.
Peer Reviewed verified by ORBi

Massart, D. L., Hubert, P., Chiap, P., Moors, M., Crommen, J., & Bourguignon, B. (1993). Knowledge-based systems for method development in solid-phase extraction. Paper presented at 10th International Bioanalytical Forum, Guilford, United Kingdom.

Bechet, I., Paques, P., Ceccato, A., Hubert, P., & Crommen, J. (1993). Analysis of basic drugs by capillary zone electrophoresis. Poster session presented at 17th International Symposium on Column Chromatography, Hamburg, Germany.

Ceccato, A., Hubert, P., Streel, B., Bechet, I., & Crommen, J. (1993). Evaluation of an alpha 1-acid glycoprotein chiral stationary phase for the enantioseparation of -blocking drugs. Poster session presented at 17th International Symposium on Column Chromatography, Hamburg, Germany.

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1993). Fully automated systems for the bioanalysis of drugs and metabolites using solid-phase extraction in combination with liquid chromatography. Paper presented at 9th International Symposium on Advances and Applications of Chromatography in Industry, Bratislava, Slovakia.

Bechet, I., Paques, P., Hubert, P., & Crommen, J. (1993). Indirect photometric detection in capillary electrophoresis. Paper presented at 9th Danube Symposium on Chromatography, Budapest, Hungary.

Hubert, P., Chiap, P., Moors, M., Massart, D. L., & Crommen, J. (1993). A hypermedia knowledge-based system for the automated solid-phase extraction of basic drugs from plasma coupled to their HPLC determination. Paper presented at 17th International Symposium on Column Chromatography, Hamburg, Germany.

Crommen, J., Bechet, I., Paques, P., Ceccato, A., & Hubert, P. (1993). Method developement and applications of capillary electrophoresis in drug analysis. Paper presented at IVth International Symposium on Pharmaceutical and Biomedical Analysis, Baltimore, United States.

Hubert, P., Chiap, P., Moors, M., Massart, D. L., & Crommen, J. (1993). Development of a knowledge-based system for the autaomated solid-phase extraction of basic drugs from plasma prior to HPLC determination. Journal de Pharmacie de Belgique, 48, 114.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Ceccato, A., Bechet, I., Sibenaler-Dechamps, R., Maes, P., & Crommen, J. (1992). Determination of verapamil and norverapamil in human plasma by liquid chromatography: comparison between a liquid-liquid extraction procedure and an automated liquid-solid extraction method for sample preparation. Journal of Pharmaceutical and Biomedical Analysis, 10 (10-12), 937-42. doi:10.1016/0731-7085(91)80102-F
Peer Reviewed verified by ORBi

Bechet, I., Ceccato, A., Hubert, P., Herné, P., & Crommen, J. (1992). Determination of Meprobamate in Pharmaceutical Dosage Forms Also Containing Carbromal by Liquid Chromatography and Indirect Photometric Detection. Journal of Pharmaceutical and Biomedical Analysis, 10 (10-12, Oct-Dec), 995-9. doi:10.1016/0731-7085(91)80110-U
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Sibenaler-Dechamps, R., Maes, P., & Crommen, J. (1992). Comparison of liquid-liquid extraction and liquid-solid extraction methods for the HPLC determination of verapamil and norverapamil in human plasma. Journal de Pharmacie de Belgique, 47, 259.
Peer Reviewed verified by ORBi

Maes, P., Sibenaler-Dechamps, R., Zimmer, C., Renson, M., Hubert, P., & Crommen, J. (1992). Comparison of two automated solid-phase extraction methods for the HPLC determination of nifedipine in human plasma with electrochemical detection. Journal de Pharmacie de Belgique, 47, 198.
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., Bechet, I., & Crommen, J. (1992). Enantiomeric separation of basic drugs on an ovomucoid column. Journal de Pharmacie de Belgique, 47, 249.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Ceccato, A., & Crommen, J. (1992). HPLC determination of propranolol, verapamil and norverapamil in plasma using automated liquid-solid extraction and fluorometric detection. Journal de Pharmacie de Belgique, 47, 196.
Peer Reviewed verified by ORBi

Hubert, P., Renson, M., Gerardy-Moies, C., Bechet, I., & Crommen, J. (1992). Comparison between column switching and SPE on disposable cartridges in the automatic determination of indomethacin in plasma by HPLC. Journal de Pharmacie de Belgique, 47, 197.
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., Bechet, I., & Crommen, J. (1992). Automated HPLC analysis of diltiazem and desacetyldiltiazem in plasma using disposabele extraction cartridges. Journal de Pharmacie de Belgique, 47, 196.
Peer Reviewed verified by ORBi

Hubert, P., Evrard, B., Delattre, L., & Crommen, J. (1992). Automated determination of sulfadimidine in ovine plasma by solid phase extraction and HPLC. Journal de Pharmacie de Belgique, 47, 197.
Peer Reviewed verified by ORBi

Bechet, I., Ceccato, A., Hubert, P., & Crommen, J. (1992). Separation and quantitative analysis of amino acids by capillary zone electrophoresis with indirect photometric detection. Journal de Pharmacie de Belgique, 47, 181.
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., Bechet, I., & Crommen, J. (1992). Optimization of separation and sensitivity in the analysis of amino acids by capillary zone electrophoresis and indirect UV detection. Poster session presented at XIXth International Symposium on Chromatography, Aix en Provence, France.

Bechet, I., Hubert, P., Ceccato, A., & Crommen, J. (1992). Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC. Paper presented at Vth Symposium on Handling of Environmental and Biological Samples in Chromatography, Baden-Baden, Germany.

Hubert, P., Chiap, P., & Crommen, J. (1991). Automatic Determination of Diltiazem and Desacetyldiltiazem in Human Plasma Using Liquid-Solid Extraction on Disposable Cartridges Coupled to Hplc--Part I: Optimization of the Hplc System and Method Validation. Journal of Pharmaceutical and Biomedical Analysis, 9 (10-12), 877-882. doi:10.1016/0731-7085(91)80017-4
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., & Crommen, J. (1991). Automatic Determination of Diltiazem and Desacetyldiltiazem in Human Plasma Using Liquid-Solid Extraction on Disposable Cartridges Coupled to Hplc--Part II: Optimization of Liquid-Solid Extraction. Journal of Pharmaceutical and Biomedical Analysis, 9 (10-12), 883-887. doi:10.1016/0731-7085(91)80018-5
Peer Reviewed verified by ORBi

Hubert, P., Maes, P., & Crommen, J. (1991). Fully automated analysis of verapamil and norverapamil in plasma by on-line coupling of liquid-solid extraction to HPLC. Journal de Pharmacie de Belgique, 46, 148.
Peer Reviewed verified by ORBi

Bechet, I., Hubert, P., & Crommen, J. (1991). Indirect photometric detection of amino acids in capillary zone electrophoresis. Journal de Pharmacie de Belgique, 46, 143.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., & Crommen, J. (1991). Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC. Poster session presented at Vth Symposium on Handling of Environmental and Biological Samples in Chromatography, Baden-Baden, Germany.

Hubert, P., & Crommen, J. (1991). Fully automated determination of verapamil and norverapamil in plasma using liquid-solid extraction and HPLC with fluorescence detection. Poster session presented at IVth International Symposium on Quantitative Luminescence Spectroscopy in Biomedical Sciences, Gand, Belgium.

Crommen, J., Bechet, I., & Hubert, P. (1991). Indirect detection techniques in liquid chromatography and capillary electrophoresis. Paper presented at VIIIth Danube Symposium on Chromatography, Warshaw, Poland.

Hubert, P., Chiap, P., & Crommen, J. (1991). Fully automated analysis of basic drugs in plasma using liquid-solid extraction on individual cartridges and HPLC. Paper presented at IIIrd International Symposium on Pharmaceutical and Biomedical Analysis, Boston, United States.

Hubert, P. (1991). Dosage entièrement automatisé de l'indométhacine dans le plasma, par extraction liquide-solide sur cartouches à usage unique associée à la chromatographie liquide haute performance. Unpublished DEA/DES thesis, ULiège - Université de Liège.
Jury: Crommen, J. (Promotor).

Hubert, P., & Crommen, J. (1990). Fully automated determination of indomethacin in plasma using liquid-solid extraction coupled to HPLC. Journal de Pharmacie de Belgique, 45, 92.
Peer Reviewed verified by ORBi

Hubert, P., & Crommen, J. (1990). Optimisation of automated liquid-solid extraction using disposable cartridges in the HPLC analysis of drugs in plasma. Poster session presented at IInd International Symposium on Pharmaceutical and Biomedical Analysis, York, United Kingdom.

Hubert, P., Renson, M., & Crommen, J. (1989). A fully automated HPLC method for the determination of indomethacin in plasma. Poster session presented at IIIrd International Symposium on Drug Analysis, Antwerp, Belgium.

Hubert, P., Renson, M., & Crommen, J. (1989). A Fully Automated High-Performance Liquid Chromatographic Method for the Determination of Indomethacin in Plasma. Journal of Pharmaceutical and Biomedical Analysis, 7 (12), 1819-27. doi:10.1016/0731-7085(89)80199-2
Peer Reviewed verified by ORBi

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