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Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues
Cornaglia, G.; Akova, M.; Amicosante, G. et al.
2007In International Journal of Antimicrobial Agents, 29 (4), p. 380-388
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Keywords :
metallo-beta-lactamases; antimicrobial resistance
Abstract :
[en] The rapid spread of acquired metallo-beta-lactamases (MBLs) among major Gram-negative pathogens is a matter of particular concern worldwide and primarily in Europe, one of first continents where the emergence of acquired MBLs has been reported and possibly the geographical area where the increasing diversity of these enzymes and the number of bacterial species affected are most impressive. This spread has not been paralleled by accuracy/standardisation of detection methods, completeness of epidemiological knowledge or a clear understanding of what MBL production entails in terms of clinical impact, hospital infection control and antimicrobial chemotherapy. A number of European experts in the field met to review the current knowledge on this phenomenon, to point out open issues and to reinforce and relate to one another the existing activities set forth by research institutes, scientific societies and European Union-driven networks. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Disciplines :
Pharmacy, pharmacology & toxicology
Immunology & infectious disease
Microbiology
Author, co-author :
Cornaglia, G.
Akova, M.
Amicosante, G.
Canton, R.
Cauda, R.
Docquier, Jean-Denis ;  Université de Liège - ULiège > Département des sciences de la vie > Centre d'ingénierie des protéines
Edelstein, M.
Frère, Jean-Marie ;  Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Fuzi, M.
Galleni, Moreno ;  Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Giamarellou, H.
Gniadkowski, M.
Koncan, R.
Libisch, B.
Luzzaro, F.
Miriagou, V.
Navarro, F.
Nordmann, P.
Pagani, L.
Peixe, L.
Poirel, L.
Souli, M.
Tacconelli, E.
Vatopoulos, A.
Rossolini, G. M.
More authors (15 more) Less
Language :
English
Title :
Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues
Publication date :
April 2007
Journal title :
International Journal of Antimicrobial Agents
ISSN :
0924-8579
eISSN :
1872-7913
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
29
Issue :
4
Pages :
380-388
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 December 2010

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