Profil

Frère Jean-Marie

Département des sciences de la vie > Macromolécules biologiques

Centre d'Ingénierie des Protéines (CIP)

See author's contact details
Main Referenced Co-authors
Galleni, Moreno  (122)
Ghuysen, Jean-Marie  (118)
Joris, Bernard  (92)
Charlier, Paulette  (42)
Duez, Colette  (41)
Main Referenced Keywords
Kinetics (39); Amino Acid Sequence (31); kinetics (31); Molecular Sequence Data (30); Models, Molecular (25);
Main Referenced Unit & Research Centers
CIP - Centre d'Ingénierie des Protéines - ULiège [BE] (32)
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE] (5)
CWBI ; Centre d'Ingénierie des Protéines (1)
Center for Education and Research on Macromolecules (CERM) (1)
InBios - Integrative Biological Sciences - ULiège [BE] (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (312)
Microbiology (125)
Pharmacy, pharmacology & toxicology (18)
Chemistry (9)
Immunology & infectious disease (8)

Publications (total 375)

The most downloaded
732 downloads
Kelly, J. A., Dideberg, O., Charlier, P., Wery, J.-P., Libert, M., Moews, P., Knox, J., Duez, C., Fraipont, C., Joris, B., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (21 March 1986). On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target. Science, 231, 1429-1431. doi:10.1126/science.3082007 https://hdl.handle.net/2268/66947

The most cited

884 citations (Scopus®)

Ambler, R. P., Coulson, A. F. W., Frère, J.-M., Ghuysen, J.-M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., & Waley, S. G. (15 May 1991). A standard numbering scheme for the class A beta-lactamases. Biochemical Journal, 276 (Pt 1), 269-270. doi:10.1042/bj2760269 https://hdl.handle.net/2268/81167

Frère, J.-M., Verlaine, O., & Matagne, A. (12 September 2023). The measurement of true initial rates is not always absolutely necessary to estimate enzyme kinetic parameters. Scientific Reports, 13 (1), 15053. doi:10.1038/s41598-023-41805-y
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Radwanska, M., De Lemos Esteves, F., Linsen, L., Coltel, N., Cencig, S., Widart, J., Massart, A.-C., Colson, S., Di Paolo, A., Percier, P., Ait Djebbara, S., Guillonneau, F., Flamand, V., De Pauw, E., Frère, J.-M., Carlier, Y., & Truyens, C. (23 March 2023). Macrophage-infectivity potentiator of Trypanosoma cruzi (TcMIP) is a new pro-type 1 immuno-stimulating protein for neonatal human cells and vaccines in mice. Frontiers in Immunology, 14, 1138526. doi:10.3389/fimmu.2023.1138526
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Lupo, V., Mercuri, P., Frère, J.-M., Joris, B., Galleni, M., Baurain, D.* , & Kerff, F.*. (2022). An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains. Microbiology Spectrum, 10 (2), 0031522. doi:10.1128/spectrum.00315-22
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* These authors have contributed equally to this work.

Terrak, M., & Frère, J.-M. (2021). β‐Lactam Antibiotics. In S. Offermanns & W. Rosenthal (Eds.), Encyclopedia of Molecular Pharmacology (3rd ed. Encyclopedia of Molecular Pharmacology). Springer, Cham. doi:10.1007/978-3-030-21573-6_29-1
Peer reviewed

Guillerm, J., Frère, J.-M., Meersman, F., & Matagne, A. (2021). The Right-Handed Parallel β-Helix Topology of Erwinia chrysanthemi Pectin Methylesterase Is Intimately Associated with Both Sequential Folding and Resistance to High Pressure. Biomolecules, 11 (8), 1083. doi:10.3390/biom11081083
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Gavara, L., Sevaille, L., De Luca, F., Mercuri, P., Bebrone, C., Feller, G., Legru, A., Cerboni, G., Tanfoni, S., Baud, D., Cutolo, G., Bestgen, B., Chelini, G., Verdirosa, F., Sannio, F., Pozzi, C., Benvenuti, M., Kwapien, K., Fischer, M., ... Hernandez, J.-F. (2020). 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. European Journal of Medicinal Chemistry, 208, 112720. doi:10.1016/j.ejmech.2020.112720
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Mack, A. R., Barnes, M. D., Taracila, M. A., Hujer, A. M., Hujer, K. M., Cabot, G., Feldgarden, M., Haft, D. H., Klimke, W., Van Den Akker, F., Vila, A. J., Smania, A., Haider, S., Papp-Wallace, K. M., Bradford, P. A., Rossolini, G. M., Docquier, J.-D., Frère, J.-M., Galleni, M., ... Bonomo, R. A. (2020). A standard numbering scheme for class C β-lactamases. Antimicrobial Agents and Chemotherapy, 64 (3). doi:10.1128/AAC.01841-19
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Frère, J.-M., & Verlaine, O. (2020). First-order Kinetics in the Study of Enzymes: Applications to the Reporter Substrate Method and to the Estimation of kcat/Km. Current Biotechnology.
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Frère, J.-M., Bogaerts, P., Huang, T.-D., Stefanic, P., Moray, J., Bouillenne, F., & Brans, A. (2020). Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases. Biomolecules, 10 (3). doi:10.3390/biom10030483
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Renders, M., Dumbre, S., Abramov, M., Kestemont, D., Margamuljana, L., Largy, E., Cozens, C., Vandenameele, J., Pinheiro, V. B., Toye, D., Frère, J.-M., & Herdewijn, P. (2019). Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases. Nucleic Acids Research, 47 (5), 2160-2168. doi:10.1093/nar/gkz008
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Renders, M., Frère, J.-M., Toye, D., & Herdewijn, P. (2019). Full Pre-Steady-State Kinetic Analysis of Single Nucleotide Incorporation by DNA Polymerases. Current Protocols in Nucleic Acid Chemistry, 78 (1), 98. doi:10.1002/cpnc.98
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Amisano, F., Silvestri, M., Mercuri, P., Gagliardi, A., Bini, L., Frère, J.-M., & Galleni, M. (17 June 2017). Study of the outer membrane permeability of Pseudomonas aeruginosa to ß-lactam antibiotics [Poster presentation]. 13th Beta lactamase meeting, Santo Stefano di Sessanio, Italy.

Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., ... Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186
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Abboud, M., Damblon, C., Brem, J., Smargiasso, N., Mercuri, P., Gilbert, B., Rydzik, A., Claridge, T., Schofield, C., & Frère, J.-M. (September 2016). Interaction of Avibactam with Class B Metallo-β-Lactamases. Antimicrobial Agents and Chemotherapy, 60, 5655-6. doi:10.1128/AAC.00897-16
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Lefurgy, S. T., Malashkevich, V. N., Aguilan, J. T., Nieves, E., Mundorff, E. C., Biju, B., Noel, M. A., Toro, R., Baiwir, D., Papp-Wallace, K. M., Almo, S. C., Frère, J.-M., Bou, G., & Bonomo, R. A. (February 2016). Analysis of the Structure and Function of FOX-4 Cephamycinase. Antimicrobial Agents and Chemotherapy, 60 (2), 717-728. doi:10.1128/AAC.01887-15
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Fernea, A., Galleni, M., & Frère, J.-M. (2016). Kinetics of the Interaction between BAL29880 and LK157 and the Class C β-Lactamase CHE-1. Antimicrobial Agents and Chemotherapy, 60, 1747-1750. doi:10.1128/AAC.02062-15
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Frère, J.-M., Sauvage, E., & Kerff, F. (2016). From "an enzyme able to destroy penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour. Current Drug Targets. doi:10.2174/1389450116666151001112859
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Baurain, D., Wilmotte, A., & Frère, J.-M. (2016). Gram-Negative Bacteria: "Inner" vs. "Cytoplasmic" or "Plasma Membrane": A Question of Clarity rather than Vocabulary. Journal of Microbial and Biochemical Technology, 8 (4), 325-326. doi:10.4172/1948-5948.1000305

Jourdan, S.* , Francis, I.* , Kim, M., Salazar, J., Planckaert, S., Frère, J.-M., Matagne, A., Kerff, F., Devreese, B., Loria, R., & Rigali, S. (2016). The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity. Scientific Reports. doi:10.1038/srep27144
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* These authors have contributed equally to this work.

Frère, J.-M., & Rigali, S. (2016). The alarming increase in antibiotic-resistant bacteria. Drug Target Review.

Fernea, A., Galleni, M., & Frère, J.-M. (2015). Kinetics of the interaction between avibactam and the CHE-1 class C beta-lactamase. Journal of Antimicrobial Chemotherapy, 70 (3), 951-953. doi:10.1093/jac/dku442
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Kerff, F., El Ghachi, M., Herman, R., Sauvage, E., Frère, J.-M., & Charlier, P. (06 September 2014). Structures of the Carbapenemase OXA-24 in Complex with the β-lactamase Inhibitor Avibactam [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia.

Frère, J.-M., & Page, M. G. P. (2014). Penicillin-binding proteins: evergreen drug targets. Current Opinion in Pharmacology, 18, 112-9. doi:10.1016/j.coph.2014.09.012
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Sauvage, E., & Frère, J.-M. (2013). Actinomadura R39 d-Ala-d-Ala Carboxypeptidase. In Handbook of Proteolytic Enzymes (pp. 3480-3484). Elsevier. doi:10.1016/B978-0-12-382219-2.00771-7
Peer reviewed

Dumez, M.-E., Herman, J., Campisi, V., Bouaziz, A., Rosu, F., Luxen, A., Vandenberghe, I., De Pauw, E., Frère, J.-M., Matagne, A., Chevigne, A., & Galleni, M. (2013). The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction. PLoS ONE, 8 (9), 68014. doi:10.1371/journal.pone.0068014
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Zervosen, A., Zapun, A., & Frère, J.-M. (January 2013). Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline. Antimicrobial Agents and Chemotherapy, 57 (1), 661-663. doi:10.1128/AAC.01593-12
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Zervosen, A., Sauvage, E., Frère, J.-M., Charlier, P., & Luxen, A. (2012). Development of new drugs for an old target — the penicillin binding proteins. Molecules, 17 (11), 12478-505. doi:10.3390/molecules171112478
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Kupper, M., Bauvois, C., Frère, J.-M., Galleni, M., & Bebrone, C. (January 2012). The CphAII protein from Aquifex aeolicus exhibits a metal-dependent phosphodiesterase activity. Extremophiles: Life Under Extreme Conditions, 16(1), 45-55. doi:10.1007/s00792-011-0404-1
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Docquier, J.-D., Rossolini, G. M., Nikaido, H., & Frère, J.-M. (2012). Interplay between beta-lactamase activity, outer membrane and active efflux system. In J.-M. Frère, Beta-Lactamases (pp. 401-418). New York, United States: Nova Science Publishers, Inc.

Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J.-M., Masereel, B., Frederick, R., & Wouters, J. (2012). Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles. European Journal of Medicinal Chemistry, 54, 95-102. doi:10.1016/j.ejmech.2012.04.033
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Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y
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Horsfall, L., Izougarhane, Y., Lassaux, P., Selevsek, N., Liénard, B., Poirel, L., Kupper, M., Hoffmann, K., Frère, J.-M., Galleni, M., & Bebrone, C. (April 2011). Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. FEBS Journal, 278(8), 1252-1263. doi:10.1111/j.1742-4658.2011.08046.x
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Vandevenne, M., Campisi, V., Freichels, A., Gillard, C., Gaspard, G., Frère, J.-M., Galleni, M., & Filée, P. (2011). Comparative functional analysis of the human macrophage chitotriosidase. Protein Science: A Publication of the Protein Society. doi:10.1002/pro.676
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Dolusic, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J.-M., Masereel, B., Van den Eynde, B., Wouters, J., & Frederick, R. (2011). Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. European Journal of Medicinal Chemistry, 46 (7), 3058-65. doi:10.1016/j.ejmech.2011.02.049
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Lassaux, P., Traoré, D., Loisel, E., Favier, A., Docquier, J.-D., Sohier, J., Laurent, C., Bebrone, C., Frère, J.-M., Ferrer, J.-L., & Galleni, M. (2011). Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01486-09
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Bebrone, C., Kupper, M. B., Dehareng, D., Frère, J.-M., Hoffmann, K., & Galleni, M. (2011). The CphAII protein from Aquifex aeolicus possesses a metal-dependent phosphodiesterase activity [Poster presentation]. 11th β-lactamase meeting, Leonessa, Italy.
Peer reviewed

Dolusic, E., Larrieu, P., Blanc, S., Sapunaric, F., Norberg, B., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J.-M., Masereel, B., Van den Eynde, B., Wouters, J., & Frederick, R. (2011). Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Bioorganic and Medicinal Chemistry, 19 (4), 1550-61. doi:10.1016/j.bmc.2010.12.032
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Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008
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Vandevenne, M., GASPARD, G., Belgsir, E. M., Ramnath, M., Cenatiempo, Y., Delneuville, D., Dumoulin, M., Frère, J.-M., Matagne, A., Galleni, M., & Filee, P. (2011). Effects of monopropanediamino-beta-cyclodextrin on the denaturation process of the hybrid protein BlaPChBD. Biochimica et Biophysica Acta. doi:10.1016/j.bbapap.2011.05.007
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Vercheval, L., Di Paolo, A., Borel, F., Ferrer, J.-L., Sauvage, E., Matagne, A., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (25 November 2010). Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys 70. Biochemical Journal, 432 (3), 495-504. doi:10.1042/BJ20101122
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Weide, T., Saldanha, S. A., Minond, D., Spicer, T., Fotsing, J., Spaargaren, M., Frère, J.-M., Bebrone, C., Sharpless, B., Hodder, P., & Fokin, V. (July 2010). NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β- Lactamase: Synthesis and Structure-Activity Studies. ACS Medicinal Chemistry Letters, 1(4), 150-154.
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Lassaux, P., Hamel, M., Gulea, M., Delbrück, H., Mercuri, P., Horsfall, L., Dehareng, D., Kupper, M., Frère, J.-M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases. Journal of Medicinal Chemistry, 53, 4862–4876. doi:10.1021/jm100213c
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Borgianni, L., Vandenameele, J., Matagne, A., Bini, L., Bonomo, R. A., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2010). Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. Antimicrobial Agents and Chemotherapy, 54 (8), 3197-204. doi:10.1128/AAC.01336-09
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Kerff, F., Petrella, S., Mercier, F., Sauvage, E., Herman, R., Pennartz, A., Zervosen, A., Luxen, A., Frère, J.-M., Joris, B., & Charlier, P. (2010). Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family. Journal of Molecular Biology, 397, 249-259. doi:10.1016/j.jmb.2009.12.038
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Phichith, D., Bun, S., Padiolleau-Lefevre, S., Guellier, A., Banh, S., Galleni, M., Frère, J.-M., Thomas, D., Friboulet, A., & Avalle, B. (2010). Novel peptide inhibiting both TEM-1 beta-lactamase and penicillin-binding proteins. FEBS Journal, 277 (23), 4965-72. doi:10.1111/j.1742-4658.2010.07906.x
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Vandenameele, J., Lejeune, A., Di Paolo, A., Brans, A., Frère, J.-M., Schmid, F. X., & Matagne, A. (2010). Folding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways. Biochemistry, 49 (19), 4264-75. doi:10.1021/bi100369d
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Mercier, F., Zervosen, A., Teller, N., Frère, J.-M., Herman, R., Pennartz, A., Joris, B., & Luxen, A. (2010). 1,6-AnhMurNAc derivatives for assay development of amidase AmiD. Bioorganic and Medicinal Chemistry, 18 (21), 7422-31. doi:10.1016/j.bmc.2010.09.010
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Zervosen, A., Frère, J.-M., & Zapun, A. (May 2009). Enzymatic Inhibition of Streptococcus pneumoniae PBP2x transpeptidase activity by ceftaroline [Poster presentation]. 19th ECCMID, Helsinki, Finland.

Bebrone, C., Delbrück, H., Kupper, M., Schlömer, P., Willmann, C., Frère, J.-M., Fisher, R., Galleni, M., & Hoffmann, K. (2009). The structure of the di-zinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the "histidine" site. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00288-09
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Jacquin, O., Balbeur, D., Damblon, C., Marchot, P., De Pauw, E., Roberts, G. C. K., Frère, J.-M., & Matagne, A. (2009). Positively Cooperative Binding of Zinc Ions to Bacillus cereus 569/H/9 beta-Lactamase II Suggests that the Binuclear Enzyme Is the Only Relevant Form for Catalysis. Journal of Molecular Biology, 392 (5), 1278-1291. doi:10.1016/j.jmb.2009.07.092
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Baurin, S., Vercheval, L., Bouillenne, F., Falzone, C., Brans, A., Jacquamet, L., Ferrer, J.-L., Sauvage, E., Dehareng, D., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (2009). Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases. Biochemistry, 48 (47), 11252-63. doi:10.1021/bi901548c
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Zeba, B., De Luca, F., Dubus, A., Delmarcelle, M., Simporé, J., Nacoulma, O. G., Rossolini, G. M., Frère, J.-M., & Docquier, J.-D. (2009). IND-6, a Highly Divergent IND-type Metallo-{beta}-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01607-08
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Bebrone, C., Delbrück, H., Wilmann, C., Galleni, M., Frère, J.-M., & Hoffmann, K. (2009). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc ion binds in the Histidine site [Poster presentation]. “Penicillin-recognizing enzymes: from enzyme kinetics to protein folding” symposium, Liège, Belgium.

Duez, C., Zervosen, A., Teller, N., Melkonian, R., Banzubazé, E., Bouillenne, F., Luxen, A., & Frère, J.-M. (2009). Characterization of the proteins encoded by the Bacillus subtilis yoxA-dacC operon. FEMS Microbiology Letters, 300, 42-47. doi:10.1111/j.1574-6968.2009.01761.x
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Lejeune, A., Pain, R. H., Charlier, P., Frère, J.-M., & Matagne, A. (29 January 2008). Tem-1 Beta-Lactamase Folds in a Nonhierarchical Manner with Transient Non-Native Interactions Involving the C-Terminal Region. Biochemistry, 47 (4), 1186-93. doi:10.1021/bi701927y
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Bebrone, C., Delbrück, H., Kupper, M. B., Galleni, M., Frère, J.-M., & Hoffmann, K. (2008). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc binds in the Histidine site [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany.
Peer reviewed

Stoczko, M., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2008). Functional diversity among metallo-β-lactamases: Characterization of the CAR-1 enzyme of Erwinia carotovora. Antimicrobial Agents and Chemotherapy, 52 (7), 2473-2479. doi:10.1128/AAC.01062-07
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Michaux, C., Massant, J., Kerff, F., Frère, J.-M., Docquier, J.-D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J., & Wouters, J. (2008). Crystal structure of a cold-adapted class C beta-lactamase. FEBS Journal, 275 (8), 1687-97. doi:10.1111/j.1742-4658.2008.06324.x
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Dumez, M.-E., Teller, N., Mercier, F., Tanaka, T., Vandenberghe, I., Vandenbranden, M., Devreese, B., Luxen, A., Frère, J.-M., Matagne, A., Jacquet, A., Galleni, M., & Chevigne, A. (2008). Activation mechanism of recombinant Der p 3 allergen zymogen - Contribution of cysteine protease Der p 1 and effect of propeptide glycosylation. Journal of Biological Chemistry, 283 (45), 30606-30617. doi:10.1074/jbc.M803041200
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Ruth, N., Quinting, B., Mainil, J., Hallet, B., Frère, J.-M., Huygen, K., & Galleni, M. (2008). Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a class A beta-lactamase. FEBS Journal, 275, 5151-5160. doi:10.1111/j.1742-4658.2008.06646.x
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Hubert, S., Rigali, S., Bebrone, C., Kupper, M. B., Hoffmann, K., Vanhulle, S., & Frère, J.-M. (2008). Analysis of the enzymatic component of ligninolytic system of Pycnoporus sanguineus PS7 [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany.
Peer reviewed

Lienard, B. M. R., Garau, G., Horsfall, L., Karsisiotis, A. I., Damblon, C., Lassaux, P., Papamicael, C., Roberts, G. C. K., Galleni, M., Dideberg, O., Frère, J.-M., & Schofield, C. J. (2008). Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Organic and Biomolecular Chemistry, 6 (13), 2282-2294. doi:10.1039/b802311e
Peer Reviewed verified by ORBi

Vandevenne, M., Gaspard, G., Yilmaz, N., Giannotta, F., Frère, J.-M., Galleni, M., & Filée, P. (2008). Rapid and easy development of versatile tools to study protein/ligand interactions. Protein Engineering, Design and Selection. doi:10.1093/protein/gzn021
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Lienard, B. M. R., Huting, R., Lassaux, P., Galleni, M., Frère, J.-M., & Schofield, C. J. (2008). Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors. Journal of Medicinal Chemistry, 51 (3), 684-8. doi:10.1021/jm070866g
Peer Reviewed verified by ORBi

Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375
Peer Reviewed verified by ORBi

Chevigné, A., Barumandzadeh, R., Groslambert, S., Cloes, B., Dehareng, D., Filée, P., Marx, J.-C., Frère, J.-M., Matagne, A., Jacquet, A., & Galleni, M. (16 November 2007). Relationship between propeptide pH unfolding and inhibitory ability during ProDer p 1 activation mechanism. Journal of Molecular Biology, 374 (1), 170-185. doi:10.1016/j.jmb.2007.08.025
Peer Reviewed verified by ORBi

Faure, E., Halusiak, E., Ruth, N., Gabriel, S., Filée, P., Giannotta, F., Frère, J.-M., Galleni, M., Jérôme, C., & Jérôme, R. (31 August 2007). Biosensors based on electrochemically prepared polyanilines and bifunctional hybrid proteins [Poster presentation]. Polymers: Last achievements and prospects, in honour of Professor Jérôme, Liège, Belgium.

Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J. W., Adediran, S. A., Pratt, R. F., Frère, J.-M., & Charlier, P. (10 August 2007). Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Journal of Molecular Biology, 371 (2), 528-539. doi:10.1016/j.jmb.2007.05.071
Peer Reviewed verified by ORBi

Cornaglia, G., Akova, M., Amicosante, G., Canton, R., Cauda, R., Docquier, J.-D., Edelstein, M., Frère, J.-M., Fuzi, M., Galleni, M., Giamarellou, H., Gniadkowski, M., Koncan, R., Libisch, B., Luzzaro, F., Miriagou, V., Navarro, F., Nordmann, P., Pagani, L., ... Rossolini, G. M. (April 2007). Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. International Journal of Antimicrobial Agents, 29 (4), 380-388. doi:10.1016/j.ijantimicag.2006.10.008
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Chevigné, A., Yilmaz, N., Gaspard, G., Giannotta, F., François, J.-M., Frère, J.-M., Galleni, M., & Filée, P. (30 March 2007). Use of bifunctional hybrid beta-lactamases for epitope mapping and immunoassay development. Journal of Immunological Methods, 320 (1-2), 81-93. doi:10.1016/j.jim.2006.12.009
Peer Reviewed verified by ORBi

Lienard, B. M. R., Horsfall, L. E., Galleni, M., Frère, J.-M., & Schofield, C. J. (15 February 2007). Inhibitors of the FEZ-1 metallo-beta-lactamase. Bioorganic and Medicinal Chemistry Letters, 17 (4), 964-968. doi:10.1016/j.bmcl.2006.11.053
Peer Reviewed verified by ORBi

Ishii, Y., Galleni, M., Ma, L., Frère, J.-M., & Yamaguchi, K. (February 2007). Biochemical characterisation of the CTX-M-14 beta-lactamase. International Journal of Antimicrobial Agents, 29 (2), 159-164. doi:10.1016/j.ijantimicag.2006.09.005
Peer Reviewed verified by ORBi

Vandevenne, M., Filée, P., Scarafone, N., Cloes, B., Gaspard, G., Yilmaz, N., Dumoulin, M., François, J.-M., Frère, J.-M., & Galleni, M. (2007). The Bacillus licheniformis BlaP beta-lactamase as a model protein scaffold to study the insertion of protein fragments. Protein Science: A Publication of the Protein Society, 16 (10), 2260-71. doi:10.1110/ps.072912407
Peer Reviewed verified by ORBi

Gangoue Pieboji, J., Baurin, S., Frère, J.-M., Ngassam, P., Ngameni, B., Azebaze, A., Pegnyemb, D. E., Watchueng, J., Goffin, C., & Galleni, M. (2007). Screening of some medicinal plants from cameroon for beta-lactamase inhibitory activity. Phytotherapy Research, 21 (3), 284-7. doi:10.1002/ptr.2001
Peer Reviewed verified by ORBi

Lassaux, P., Hamel, M., Gulea, M., Mercuri, P., Horsfall, L., Bebrone, C., Gaumont, A.-C., Frère, J.-M., & Galleni, M. (2007). Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. International Journal of Antimicrobial Agents, 29 (Supplément 2), 95.
Peer Reviewed verified by ORBi

Giannotta, Filée, P., Galleni, M., Frère, J.-M., Joris, B., Brans, A., & Ruth, N. (25 October 2006). Hybrid proteins of active-site serine beta-lactamase.

chouchani, C., Berlemont, R., masmoudi, A., Galleni, M., Frère, J.-M., belhadj, O., & ben-mahrez, K. (September 2006). A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis. Antimicrobial Agents and Chemotherapy, 50 (9), 3183-5. doi:10.1128/AAC.00388-06
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Fraipont, C., Sapunaric, F., Zervosen, A., Auger, G., Devreese, B., Lioux, T., Blanot, D., Mengin-Lecreulx, D., Herdewijn, P., Van Beeumen, J., Frère, J.-M., & Nguyen-Distèche, M. (28 March 2006). Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: Specificity profile for the substrate. Biochemistry, 45 (12), 4007-4013. doi:10.1021/bi051055m
Peer Reviewed verified by ORBi

Zawadzka-Skomial, J., Markiewicz, Z., Nguyen-Distèche, M., Devreese, B., Frère, J.-M., & Terrak, M. (March 2006). Characterization of the bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 of Listeria monocytogenes. Journal of Bacteriology, 188 (5), 1875-1881. doi:10.1128/JB.188.5.1875-1881.2006
Peer Reviewed verified by ORBi

De Vriendt, K., Van Driessche, G., Devreese, B., Bebrone, C., Anne, C., Frère, J.-M., Galleni, M., & Van Beeumen, J. (February 2006). Monitoring the zinc affinity of the metallo-beta-lactamase CphA by automated nanoESI-MS. Journal of the American Society for Mass Spectrometry, 17 (2), 180-188. doi:10.1016/j.jasms.2005.10.007
Peer Reviewed verified by ORBi

Stoczko, M., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2006). Postgenomic scan of metallo-β-lactamase homologues in rhizobacteria: Identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum. Antimicrobial Agents and Chemotherapy, 50 (6), 1973-1981. doi:10.1128/AAC.01551-05
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Sauvage, E., Fonze, E., Quinting, B., Galleni, M., Frère, J.-M., & Charlier, P. (2006). Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity. Antimicrobial Agents and Chemotherapy, 50 (7), 2516-21. doi:10.1128/AAC.01226-05
Peer Reviewed verified by ORBi

Trovaslet, M., Bebrone, C., Enaud, E., Hubert, S., Nouaimeh, N., Pamplona, M., Lorenzini, B., Bols, C.-M., Frère, J.-M., & Corbisier, A.-M. (2006). Kinetic activation of Pycnoporus sanguineus laccase in presence of dyes [Poster presentation]. 3rd European Meeting in Oxizymes, Oeiras, Portugal.
Peer reviewed

Rhazi, N., Delmarcelle, M., Sauvage, E., Jacquemotte, F., Devriendt, K., Tallon, V., Ghosez, L., & Frère, J.-M. (November 2005). Specificity and reversibility of the transpeptidation reaction catalyzed by the Streptomyces R61 D-Ala-D-Ala peptidase. Protein Science: A Publication of the Protein Society, 14 (11), 2922-2928. doi:10.1110/ps.051641005
Peer Reviewed verified by ORBi

Moreira, P. R., Duez, C., Dehareng, D., Antunes, A., Almeida-Vara, E., Frère, J.-M., Malcata, F. X., & Duarte, J. C. (10 September 2005). Molecular characterisation of a versatile peroxidase from a Bjerkandera strain. Journal of Biotechnology, 118 (4), 339-352. doi:10.1016/j.jbiotec.2005.05.014
Peer Reviewed verified by ORBi

Bebrone, C., Anne, C., De Vriendt, K., Devreese, B., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (05 August 2005). Dramatic broadening of the substrate profile of the Aeromonas hydrophila CphA metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 280 (31), 28195-28202. doi:10.1074/jbc.M414052200
Peer Reviewed verified by ORBi

Deleu, M., Brasseur, R., Paquot, M., Legros, H., Dufour, S., Jacques, P., Destain, J., Thonart, P., Brans, A., Joris, B., & Frère, J.-M. (11 May 2005). Novel use of lipopeptide preparations.

Ruth, N., Mainil, J., Roupie, V., Frère, J.-M., Galleni, M., & Huygen, K. (May 2005). DNA vaccination for the priming of neutralizing antibodies against non-immunogenic STa enterotoxin from enterotoxigenic Escherichia coli. Vaccine, 23 (27), 3618-3627. doi:10.1016/j.vaccine.2004.11.080
Peer Reviewed verified by ORBi

De Lemos Esteves, F., Gouders, T., Lamotte-Brasseur, J., Rigali, S., & Frère, J.-M. (February 2005). Improving the alkalophilic performances of the Xyl1 xylanase from Streptomyces sp S38: Structural comparison and mutational analysis. Protein Science: A Publication of the Protein Society, 14 (2), 292-302. doi:10.1110/ps.04978705
Peer Reviewed verified by ORBi

Garau, G., Bebrone, C., Anne, C., Galleni, M., Frère, J.-M., & Dideberg, O. (28 January 2005). A metallo-beta-lactamase enzyme in action: Crystal structures of the monozinc carbapenemase CphA and its complex with biapenem. Journal of Molecular Biology, 345 (4), 785-795. doi:10.1016/j.jmb.2004.10.070
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Delmarcelle, M., Boursoit, M.-C., Filée, P., Baurin, S. L., Frère, J.-M., & Joris, B. (2005). Specificity inversion of Ochrobactrum anthropi D-aminopeptidase to a D,D-carboxypeptidase with new penicillin binding activity by directed mutagenesis. Protein Science: A Publication of the Protein Society, 14, 2296-2303. doi:10.1110/ps.051475305
Peer Reviewed verified by ORBi

Bauvois, C., Ibuka, A. S., Celso, A., Alba, J., Ishii, Y., Frère, J.-M., & Galleni, M. (2005). Kinetic properties of four plasmid-mediated AmpC beta-lactamases. Antimicrobial Agents and Chemotherapy, 49 (10), 4240-6. doi:10.1128/AAC.49.10.4240-4246.2005
Peer Reviewed verified by ORBi

Sauvage, E., Herman, R., Petrella, S., Duez, C., Bouillenne, F., Frère, J.-M., & Charlier, P. (2005). Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins. Journal of Biological Chemistry, 280 (35), 31249-56. doi:10.1074/jbc.M503271200
Peer Reviewed verified by ORBi

Llinas, A., Ahmed, N., Cordaro, M., Laws, A. P., Frère, J.-M., Delmarcelle, M., Silvaggi, N. R., Kelly, J. A., & Page, M. I. (2005). Inactivation of bacterial DD-peptidase by beta-sultams. Biochemistry, 44 (21), 7738-46. doi:10.1021/bi050110o
Peer Reviewed verified by ORBi

Michaux, C., Charlier, P., Frère, J.-M., & Wouters, J. (2005). Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies. Journal of the American Chemical Society, 127 (10), 3262-3. doi:10.1021/ja0426241
Peer Reviewed verified by ORBi

Frère, J.-M., Galleni, M., Bush, K., & Dideberg, O. (2005). Is it necessary to change the classification of ß-lactamases? Journal of Antimicrobial Chemotherapy, 55 (6), 1051-1053. doi:10.1093/jac/dki155
Peer Reviewed verified by ORBi

De Lemos Esteves, F., Ruelle, V., Gouders, T., Lamotte-Brasseur, J., Quinting, B., Rigali, S., & Frère, J.-M. (December 2004). On the way of understanding the adaptation to extreme pH of family 11 xylanases: Structural comparison and mutational analysis [Poster presentation]. Bioforum, Liège, Belgium.

Vreuls, C., Filée, P., Van Melckebeke, H., Aerts, T., De Deyn, P., Llabres, G., Matagne, A., Simorre, J. P., Frère, J.-M., & Joris, B. (15 November 2004). Guanidinium chloride denaturation of the dimeric Bacillus licheniformis Blal repressor highlights an independent domain unfolding pathway. Biochemical Journal, 384 (Pt 1), 179-190. doi:10.1042/BJ20040658
Peer Reviewed verified by ORBi

Mercuri, P., Garcia-Saez, I., De Vriendt, K., Thamm, I., Devreese, B., Van Beeumen, J., Dideberg, O., Rossolini, G. M., Frère, J.-M., & Galleni, M. (06 August 2004). Probing the specificity of the subclass B3 FEZ-1 metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 279 (32), 33630-33638. doi:10.1074/jbc.M403671200
Peer Reviewed verified by ORBi

Garau, G., Garcia-Saez, I., Bebrone, C., Anne, C., Mercuri, P., Galleni, M., Frère, J.-M., & Dideberg, O. (July 2004). Update of the standard numbering scheme for class B beta-lactamases. Antimicrobial Agents and Chemotherapy, 48 (7), 2347-2349. doi:10.1128/AAC.48.7.2347-2349.2004
Peer Reviewed verified by ORBi

Dreesen, L., Sartenaer, Y., Humbert, C., Caudano, Y., Volcke, C., Mani, A. A., Peremans, A., Thiry, P., Hanique, S., & Frère, J.-M. (June 2004). Two-color-sum-frequency generation characterization of a protein monolayer adsorbed on a metallic substrate [Poster presentation]. 11 th International Conference on Vibrations at Surfaces, Bar Harbor, United States.

Dreesen, L., Sartenaer, Y., Humbert, C., Caudano, Y., Volcke, C., Mani, A. A., Peremans, A., Thiry, P., Hanique, S., & Frère, J.-M. (25 May 2004). Two-color-sum-frequency generation characterization of a protein monolayer adsorbed on a metallic substrate [Poster presentation]. Belgian Physical Society Meeting, Mons, Belgium.

Tsang, W. Y., Dhanda, A., Schofield, C. J., Frère, J.-M., Galleni, M., & Page, M. I. (05 April 2004). The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. Bioorganic and Medicinal Chemistry Letters, 14 (7), 1737-1739. doi:10.1016/j.bmcl.2004.01.047
Peer Reviewed verified by ORBi

Hanique, S., Colombo, M.-L., Goormaghtigh, E., Soumillion, P., Frère, J.-M., & Joris, B. (02 April 2004). Evidence of an intramolecular interaction between the two domains of the BlaR1 penicillin receptor during the signal transduction. Journal of Biological Chemistry, 279 (14), 14264-14272. doi:10.1074/jbc.M313488200
Peer Reviewed verified by ORBi

Zervosen, A., Lu, W.-P., Chen, Z., White, R. E., Demuth, T. P., & Frère, J.-M. (March 2004). Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones. Antimicrobial Agents and Chemotherapy, 48 (3), 961-969. doi:10.1128/AAC.48.3.961-969.2004
Peer Reviewed verified by ORBi

Colombo, M.-L., Hanique, S., Baurin, S. L., Bauvois, C., De Vriendt, K., Van Beeumen, J. J., Frère, J.-M., & Joris, B. (February 2004). The ybxI gene of Bacillus subtilis 168 encodes a class D beta-lactamase of low activity. Antimicrobial Agents and Chemotherapy, 48 (2), 484-490. doi:10.1128/AAC.48.2.484-490.2004
Peer Reviewed verified by ORBi

De Lemos Esteves, F., Ruelle, V., Lamotte-Brasseur, J., Quinting, B., & Frère, J.-M. (01 February 2004). Acidophilic adaptation of family 11 endo--1,4-xylanases: Modeling and mutational analysis. Protein Science: A Publication of the Protein Society, 13 (5), 1209–1218. doi:10.1110/ps.03556104
Peer Reviewed verified by ORBi

Dreesen, L., Humbert, C., Sartenaer, Y., Caudano, Y., Volcke, C., Mani, A. A., Peremans, A., Thiry, P. A., Hanique, S., & Frère, J.-M. (2004). Electronic and Molecular Properties of an Adsorbed Protein Monolayer Probed by Two-Color Sum-Frequency Generation Spectroscopy. Langmuir, 20 (17), 7201-7207. doi:10.1021/la0488001
Peer Reviewed verified by ORBi

Docquier, J.-D., Lopizzo, T., Liberatori, S., Prenna, M., Thaller, M. C., Frère, J.-M., & Rossolini, G. M. (2004). Biochemical characterization of the THIN-B metallo-β-lactamase of Janthinobacterium lividum. Antimicrobial Agents and Chemotherapy, 48 (12), 4778-4783. doi:10.1128/AAC.48.12.4778-4783.2004
Peer Reviewed verified by ORBi

Deleu, M., Brans, A., Brasseur, R., Destain, J., Dufour, S., Frère, J.-M., Jacques, P., Joris, B., Legros, H., Paquot, M., & Thonart, P. (2004). Novel use of lipopeptide preparations.

Grisart, B., Farnir, F., Karim, L., Cambisano, N., Kim, J.-J., Kvasz, A., Mni, M., Simon, P., Frère, J.-M., Coppieters, W., & Georges, M. (2004). Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proceedings of the National Academy of Sciences of the United States of America, 101 (8), 2398-2403. doi:10.1073/pnas.0308518100
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Frère, J.-M. (2004). B-Lactam Antibiotics. In Encyclopedic Reference of Molecular Pharmacology (pp. 679-683). Springer.

Genereux, C., Dehareng, D., Devreese, B., Van Beeumen, J., Frère, J.-M., & Joris, B. (01 January 2004). Mutational analysis of the catalytic centre of the Citrobacter freundii AmpD N-acetylmuramyl-L-alanine amidase. Biochemical Journal, 377 (Pt 1), 111-120. doi:10.1042/BJ20030862
Peer Reviewed verified by ORBi

Kerff, F., Charlier, P., Colombo, M. L., Sauvage, E., Brans, A., Frère, J.-M., Joris, B., & Fonze, E. (11 November 2003). Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis. Biochemistry, 42 (44), 12835-12843. doi:10.1021/bi034976a
Peer Reviewed verified by ORBi

Ibuka, A. S., Ishii, Y., Galleni, M., Ishiguro, M., Yamaguchi, K., Frère, J.-M., Matsuzawa, H., & Sakai, H. (16 September 2003). Crystal structure of extended-spectrum beta-lactamase Toho-1: Insights into the molecular mechanism for catalytic reaction and substrate specificity expansion. Biochemistry, 42 (36), 10634-10643. doi:10.1021/bi0342822
Peer Reviewed verified by ORBi

Alba, J., Bauvois, C., Ishii, Y., Galleni, M., Masuda, K., Ishiguro, M., Ito, M., Frère, J.-M., & Yamaguchi, K. (29 August 2003). A detailed kinetic study of Mox-1, a plasmid-encoded class C beta-lactamase. FEMS Microbiology Letters, 225 (2), 183-188. doi:10.1016/S0378-1097(03)00448-8
Peer Reviewed verified by ORBi

Wouters, J., Fonze, E., Vermeire, M., Frère, J.-M., & Charlier, P. (August 2003). Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue. Cellular and Molecular Life Sciences, 60 (8), 1764-1773. doi:10.1007/s00018-003-3189-2
Peer Reviewed verified by ORBi

Anderson, J. W., Adediran, S. A., Charlier, P., Nguyen-Distèche, M., Frère, J.-M., Nicholas, R. A., & Pratt, R. F. (01 August 2003). On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides. Biochemical Journal, 373 (Part 3), 949-955. doi:10.1042/BJ20030217
Peer Reviewed verified by ORBi

Garcia-Saez, I., Hopkins, J., Papamicael, C., Franceschini, N., Amicosante, G., Rossolini, G. M., Galleni, M., Frère, J.-M., & Dideberg, O. (27 June 2003). The 1.5-angstrom structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril. Journal of Biological Chemistry, 278 (26), 23868-23873.
Peer Reviewed verified by ORBi

Duval, V., Swinnen, M., Lepage, S., Brans, A., Granier, B., Franssen, C., Frère, J.-M., & Joris, B. (June 2003). The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of beta-lactamase synthesis. Molecular Microbiology, 48 (6), 1553-1564. doi:10.1046/j.1365-2958.2003.03520.x
Peer Reviewed verified by ORBi

Filée, P., Vreuls, C., Herman, R., Thamm, I., Aerts, T., De Deyn, P. P., Frère, J.-M., & Joris, B. (May 2003). Dimerization and DNA binding properties of the Bacillus licheniformis 749/I BlaI repressor. Journal of Biological Chemistry, 278 (19), 16482-16487. doi:10.1074/jbc.M210887200
Peer Reviewed verified by ORBi

Moali, C., Anne, C., Lamotte-Brasseur, J., Groslambert, S., Devreese, B., Van Beeumen, J., Galleni, M., & Frère, J.-M. (April 2003). Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis. Chemistry and Biology, 10 (4), 319-329. doi:10.1016/S1074-5521(03)00070-X
Peer Reviewed verified by ORBi

Rhazi, N., Charlier, P., Dehareng, D., Engher, D., Vermeire, M., Frère, J.-M., Nguyen-Distèche, M., & Fonze, E. (18 March 2003). Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42 (10), 2895-2906. doi:10.1021/bi027256x
Peer Reviewed verified by ORBi

Docquier, J.-D., Lamotte-Brasseur, J., Galleni, M., Amicosante, G., Frère, J.-M., & Rossolini, G. M. (February 2003). On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy, 51 (2), 257-266. doi:10.1093/jac/dkg067
Peer Reviewed verified by ORBi

Garcia-Saez, I., Mercuri, P., Papamicael, C., Kahn, R., Frère, J.-M., Galleni, M., Rossolini, G. M., & Dideberg, O. (24 January 2003). Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. Journal of Molecular Biology, 325 (4), 651-660. doi:10.1016/S0022-2836(02)01271-8
Peer Reviewed verified by ORBi

Vanhove, M., Zakhem, M., Devreese, B., Franceschini, N., Anne, C., Bebrone, C., Amicosante, G., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (2003). Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase. Cellular and Molecular Life Sciences, 60 (11), 2501-9. doi:10.1007/s00018-003-3092-x
Peer Reviewed verified by ORBi

Lakaye, B., Dubus, A., Joris, B., & Frère, J.-M. (September 2002). Method for estimation of low outer membrane permeability to beta-lactam antibiotics. Antimicrobial Agents and Chemotherapy, 46 (9), 2901-2907. doi:10.1128/AAC.46.9.2901-2907.2002
Peer Reviewed verified by ORBi

Wommer, S., Rival, S., Heinz, U., Galleni, M., Frère, J.-M., Franceschini, N., Amicosante, G., Rasmussen, B., Bauer, R., & Adolph, H. W. (05 July 2002). Substrate-activated zinc binding of metallo-beta-lactamases - Physiological importance of the mononuclear enzymes. Journal of Biological Chemistry, 277 (27), 24142-24147. doi:10.1074/jbc.M202467200
Peer Reviewed verified by ORBi

Docquier, J.-D., Pantanella, F., Giuliani, F., Thaller, M. C., Amicosante, G., Galleni, M., Frère, J.-M., Bush, K., & Rossolini, G. M. (June 2002). CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome. Antimicrobial Agents and Chemotherapy, 46 (6), 1823-1830. doi:10.1128/AAC.46.6.1823-1830.2002
Peer Reviewed verified by ORBi

Vessillier, S., Docquier, J.-D., Rival, S., Frère, J.-M., Galleni, M., Amicosante, G., Rossolini, G. M., & Franceschini, N. (June 2002). Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase. Antimicrobial Agents and Chemotherapy, 46 (6), 1921-1927. doi:10.1128/AAC.46.6.1921-1927.2002
Peer Reviewed verified by ORBi

Filée, P., Benlafya, K., Delmarcelle, M., Moutzourelis, G., Frère, J.-M., Brans, A., & Joris, B. (May 2002). The fate of the Blal repressor during the induction of the Bacillus licheniformis BlaP beta-lactamase. Molecular Microbiology, 44 (3), 685-694. doi:10.1046/j.1365-2958.2002.02888.x
Peer Reviewed verified by ORBi

De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687
Peer Reviewed verified by ORBi

Fonzé, E., Vanhove, M., Dive, G., Sauvage, E., Frère, J.-M., & Charlier, P. (February 2002). Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin. Biochemistry, 41 (6), 1877-1885. doi:10.1021/bi015789k
Peer Reviewed verified by ORBi

Matagne, A., Galleni, M., Laraki, N., Amicosante, G., Rossolini, G., & Frère, J.-M. (2002). Beta-lactamases, an old but ever renascent problem. In A. van Broekhoven (Ed.), Novel Frontiers in the Production of Compounds for Biomedical Use. Dordrecht, Netherlands: Kluwer Academic Publishers.
Peer reviewed

Mercuri, P., Ishii, Y., Ma, L., Rossolini, G. M., Luzzaro, F., Amicosante, G., Franceschini, N., Frère, J.-M., & Galleni, M. (2002). Clonal diversity and metallo-beta-lactamase production in clinical isolates of Stenotrophomonas maltophilia. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 8 (3), 193-200. doi:10.1089/107662902760326904
Peer Reviewed verified by ORBi

De Seny, D., Heinz, U., Wommer, S., Kiefer, M., Meyer-Klaucke, W., Galleni, M., Frère, J.-M., Bauer, R., & Adolph, H. W. (30 November 2001). Metal Ion Binding and Coordination Geometry for Wild Type and Mutants of Metallo-Beta -Lactamase from Bacillus Cereus 569/H/9 (Bcii): A Combined Thermodynamic, Kinetic, and Spectroscopic Approach. Journal of Biological Chemistry, 276 (48), 45065-78. doi:10.1074/jbc.M106447200
Peer Reviewed verified by ORBi

Lejeune, A., Vanhove, M., Lamotte-Brasseur, J., Pain, R. H., Frère, J.-M., & Matagne, A. (August 2001). Quantitative Analysis of the Stabilization by Substrate of Staphylococcus Aureus Pc1 Beta-Lactamase. Chemistry and Biology, 8 (8), 831-42. doi:10.1016/S1074-5521(01)00053-9
Peer Reviewed verified by ORBi

Vilar, M., Galleni, M., Solmajer, T., Turk, B., Frère, J.-M., & Matagne, A. (August 2001). Kinetic Study of Two Novel Enantiomeric Tricyclic Beta-Lactams Which Efficiently Inactivate Class C Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (8), 2215-23. doi:10.1128/AAC.45.8.2215-2223.2001
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Zervosen, A., Valladares, M. H., Devreese, B., Prosperi, C., Adolph, H.-W., Mercuri, P., Vanhove, M., Amicosante, G., van Beeumen, J., Frère, J.-M., & Galleni, M. (July 2001). Inactivation of Aeromonas Hydrophila Metallo-Beta-Lactamase by Cephamycins and Moxalactam. European Journal of Biochemistry, 268 (13), 3840-50. doi:10.1046/j.1432-1327.2001.02298.x
Peer Reviewed verified by ORBi

Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J.-D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J.-M., & Galleni, M. (June 2001). Centa as a Chromogenic Substrate for Studying Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (6), 1868-71. doi:10.1128/AAC.45.6.1868-1871.2001
Peer Reviewed verified by ORBi

Mercuri, P., Bouillenne, F., Boschi, L., Lamotte-Brasseur, J., Amicosante, G., Devreese, B., van Beeumen, J., Frère, J.-M., Rossolini, G. M., & Galleni, M. (April 2001). Biochemical Characterization of the Fez-1 Metallo-Beta-Lactamase of Legionella Gormanii Atcc 33297t Produced in Escherichia Coli. Antimicrobial Agents and Chemotherapy, 45 (4), 1254-62. doi:10.1128/AAC.45.4.1254-1262.2001
Peer Reviewed verified by ORBi

Galleni, M., Lamotte-Brasseur, J., Rossolini, G. M., Spencer, J., Dideberg, O., & Frère, J.-M. (March 2001). Standard Numbering Scheme for Class B Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (3), 660-3. doi:10.1128/AAC.45.3.660-663.2001
Peer Reviewed verified by ORBi

Duez, C., Vanhove, M., Gallet, X., Bouillenne, F., Docquier, J.-D., Brans, A., & Frère, J.-M. (March 2001). Purification and Characterization of Pbp4a, a New Low-Molecular-Weight Penicillin-Binding Protein from Bacillus subtilis. Journal of Bacteriology, 183 (5), 1595-9. doi:10.1128/JB.183.5.1595-1599.2001
Peer Reviewed verified by ORBi

Mollard, C., Moali, C., Papamicael, C., Damblon, C., Vessilier, S., Amicosante, G., Schofield, C. J., Galleni, M., Frère, J.-M., & Roberts, G. C. (2001). Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. Journal of Biological Chemistry, 276 (48), 45015-23. doi:10.1074/jbc.M107054200
Peer Reviewed verified by ORBi

Wouters, J., Charlier, P., Monnaie, D., Frère, J.-M., & Fonze, E. (2001). Expression, purification, crystallization and preliminary X-ray analysis of the native class C beta-lactamase from Enterobacter cloacae 908R and two mutants. Acta Crystallographica. Section D, Biological Crystallography, 57 (Pt 1), 162-4. doi:10.1107/S0907444900016413
Peer Reviewed verified by ORBi

Bebrone, C., Fastrez, J., Frère, J.-M., & Galleni, M. (2001). Centa as a chromogenic substrate for the study of β-lactamases [Poster presentation]. Bioforum, Liège, Belgium.

Conrath, K. E., Lauwereys, M., Galleni, M., Matagne, A., Frère, J.-M., Kinne, J., Wyns, L., & Muyldermans, S. (2001). Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. Antimicrobial Agents and Chemotherapy, 45 (10), 2807-12. doi:10.1128/AAC.45.10.2807-2812.2001
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Wouters, J., Georis, J., Engher, D., Vandenhaute, J., Dusart, J., Frère, J.-M., Depiereux, E., & Charlier, P. (2001). Crystallographic analysis of family 11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38. Acta Crystallographica. Section D, Biological Crystallography, 57 (Pt 12), 1813-9. doi:10.1107/S0907444901015153
Peer Reviewed verified by ORBi

Franceschini, N., Boschi, L., Pollini, S., Herman, R., Perilli, M., Galleni, M., Frère, J.-M., Amicosante, G., & Rossolini, G. M. (2001). Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties. Antimicrobial Agents and Chemotherapy, 45 (12), 3509-16. doi:10.1128/AAC.45.12.3509-3516.2001
Peer Reviewed verified by ORBi

Cheggour, A., Fanuel, L., Duez, C., Joris, B., Bouillenne, F., Devreese, B., Van Driessche, G., Van Beeumen, J., Frère, J.-M., & Goffin, C. (November 2000). The Dppa Gene of Bacillus Subtilis Encodes a New D-Aminopeptidase. Molecular Microbiology, 38 (3), 504-13. doi:10.1046/j.1365-2958.2000.02117.x
Peer Reviewed verified by ORBi

Georis, J., De Lemos Esteves, F., Lamotte-Brasseur, J., Bougnet, V., Devreese, B., Giannotta, F., Granier, B., & Frère, J.-M. (March 2000). An Additional Aromatic Interaction Improves the Thermostability and Thermophilicity of a Mesophilic Family 11 Xylanase: Structural Basis and Molecular Study. Protein Science: A Publication of the Protein Society, 9 (3), 466-75. doi:10.1110/ps.9.3.466
Peer Reviewed verified by ORBi

Bouillenne, F., Matagne, A., Joris, B., & Frère, J.-M. (2000). Technique for a rapid and efficient purification of the SHV-1 and PSE-2 beta-lactamases. Journal of Chromatography. B, Biomedical Sciences and Applications, 737 (1-2), 261-5. doi:10.1016/S0378-4347(99)00436-3
Peer Reviewed verified by ORBi

Concha, N. O., Janson, C. A., Rowling, P., Pearson, S., Cheever, C. A., Clarke, B. P., Lewis, C., Galleni, M., Frère, J.-M., Payne, D. J., Bateson, J. H., & Abdel-Meguid, S. S. (2000). Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor. Biochemistry, 39 (15), 4288-98. doi:10.1021/bi992569m
Peer Reviewed verified by ORBi

Bompard-Gilles, C., Villeret, V., Davies, G. J., Fanuel, L., Joris, B., Frère, J.-M., & Van Beeumen, J. (2000). A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi. Structure, 8 (2), 153-62. doi:10.1016/S0969-2126(00)00091-5
Peer Reviewed verified by ORBi

Bompard-Gilles, C., Remaut, H., Villeret, V., Prange, T., Fanuel, L., Delmarcelle, M., Joris, B., Frère, J.-M., & Van Beeumen, J. (2000). Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family. Structure, 8 (9), 971-80. doi:10.1016/S0969-2126(00)00188-X
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Franceschini, N., Caravelli, B., Docquier, J.-D., Galleni, M., Frère, J.-M., Amicosante, G., & Rossolini, G. M. (2000). Purification and biochemical characterization of the VIM-1 metallo-beta-lactamase. Antimicrobial Agents and Chemotherapy, 44 (11), 3003-7. doi:10.1128/AAC.44.11.3003-3007.2000
Peer Reviewed verified by ORBi

Boschi, L., Mercuri, P., Riccio, M. L., Amicosante, G., Galleni, M., Frère, J.-M., & Rossolini, G. M. (2000). The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases. Antimicrobial Agents and Chemotherapy, 44 (6), 1538-43. doi:10.1128/AAC.44.6.1538-1543.2000
Peer Reviewed verified by ORBi

Chantalat, L., Duee, E., Galleni, M., Frère, J.-M., & Dideberg, O. (2000). Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase. Protein Science: A Publication of the Protein Society, 9 (7), 1402-6. doi:10.1110/ps.9.7.1402
Peer Reviewed verified by ORBi

Hernandez Valladares, M., Kiefer, M., Heinz, U., Soto, R. P., Meyer-Klaucke, W., Nolting, H. F., Zeppezauer, M., Galleni, M., Frère, J.-M., Rossolini, G. M., Amicosante, G., & Adolph, H. W. (2000). Kinetic and spectroscopic characterization of native and metal-substituted beta-lactamase from Aeromonas hydrophila AE036. FEBS Letters, 467 (2-3), 221-5. doi:10.1016/S0014-5793(00)01102-9
Peer Reviewed verified by ORBi

Rhazi, N., Galleni, M., Page, M. I., & Frère, J.-M. (15 July 1999). Peptidase Activity of Beta-Lactamases. Biochemical Journal, 341 ((Pt 2)), 409-13. doi:10.1042/0264-6021:3410409
Peer Reviewed verified by ORBi

Laraki, N., Galleni, M., Thamm, I., Riccio, M. L., Amicosante, G., Frère, J.-M., & Rossolini, G. M. (April 1999). Structure of In31, a Blaimp-Containing Pseudomonas Aeruginosa Integron Phyletically Related to In5, Which Carries an Unusual Array of Gene Cassettes. Antimicrobial Agents and Chemotherapy, 43 (4), 890-901. doi:10.1128/aac.43.4.890
Peer Reviewed verified by ORBi

Matagne, A., Dubus, A., Galleni, M., & Frère, J.-M. (February 1999). The Beta-Lactamase Cycle: A Tale of Selective Pressure and Bacterial Ingenuity. Natural Product Reports, 16 (1), 1-19. doi:10.1039/a705983c
Peer Reviewed verified by ORBi

Frère, J.-M., Dubus, A., Galleni, M., Matagne, A., & Amicosante, G. (February 1999). Mechanistic Diversity of Beta-Lactamases. Biochemical Society Transactions, 27 (2), 58-63. doi:10.1042/bst0270058
Peer Reviewed verified by ORBi

Prosperi, C., Llabres, G., De Seny, D., Soto, R. P., Valladares, M. H., Laraki, N., Frère, J.-M., & Galleni, M. (25 January 1999). Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases. FEBS Letters, 443 (2), 109-11. doi:10.1016/S0014-5793(98)01689-5
Peer Reviewed verified by ORBi

Laraki, N., Franceschini, N., Rossolini, G. M., Santucci, P., Meunier, C., De Pauw, E., Amicosante, G., Frère, J.-M., & Galleni, M. (1999). Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli. Antimicrobial Agents and Chemotherapy, 43 (4), 902-6. doi:10.1128/aac.43.4.902
Peer Reviewed verified by ORBi

Bompard-Gilles, C., Villeret, V., Fanuel, L., Joris, B., Frère, J.-M., & Van Beeumen, J. (1999). Crystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis. Acta Crystallographica. Section D, Biological Crystallography, 55 (Pt 3), 699-701. doi:10.1107/S0907444998015807
Peer Reviewed verified by ORBi

Lakaye, B., Dubus, A., Lepage, S., Groslambert, S., & Frère, J.-M. (January 1999). When Drug Inactivation Renders the Target Irrelevant to Antibiotic Resistance: A Case Story with Beta-Lactams. Molecular Microbiology, 31 (1), 89-101. doi:10.1046/j.1365-2958.1999.01150.x
Peer Reviewed verified by ORBi

Fanuel, L., Thamm, I., Kostanjevecki, V., Samyn, B., Joris, B., Goffin, C., Brannigan, J., Van Beeumen, J., & Frère, J.-M. (1999). Two new aminopeptidases from Ochrobactrum anthropi active on D-alanyl-p-nitroanilide. Cellular and Molecular Life Sciences, 55 (5), 812-8. doi:10.1007/s000180050334
Peer Reviewed verified by ORBi

Paul-Soto, R., Zeppezauer, M., Adolph, H. W., Galleni, M., Frère, J.-M., Carfi, A., Dideberg, O., Wouters, J., Hemmingsen, L., & Bauer, R. (1999). Preference of Cd(II) and Zn(II) for the two metal sites in Bacillus cereus beta-lactamase II: A perturbed angular correlation of gamma-rays spectroscopic study. Biochemistry, 38 (50), 16500-6. doi:10.1021/bi9911381
Peer Reviewed verified by ORBi

Damblon, C., Prosperi, C., Lian, L. Y., Barsukov, I., Soto, R. P., Galleni, M., Frère, J.-M., & Roberts, G. C. K. (1999). H-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase. Journal of the American Chemical Society, 121 (49), 11575-11576. doi:10.1021/ja992896h
Peer Reviewed verified by ORBi

Paul-Soto, R., Bauer, R., Frère, J.-M., Galleni, M., Meyer-Klaucke, W., Nolting, H., Rossolini, G. M., DE SENY, D., Hernandez-Valladares, M., Zeppezauer, M., & Adolph, H. W. (1999). Mono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism. Journal of Biological Chemistry, 274 (19), 13242-9. doi:10.1074/jbc.274.19.13242
Peer Reviewed verified by ORBi

Fanuel, L., Goffin, C., Cheggour, A., Devreese, B., Van Driessche, G., Joris, B., Van Beeumen, J., & Frère, J.-M. (1999). The DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family. Biochemical Journal, 341 (Pt 1), 147-55. doi:10.1042/0264-6021:3410147
Peer Reviewed verified by ORBi

Rossolini, G. M., Franceschini, N., Lauretti, L., Caravelli, B., Riccio, M. L., Galleni, M., Frère, J.-M., & Amicosante, G. (1999). Cloning of a Chryseobacterium (Flavobacterium) meningosepticum chromosomal gene (blaA(CME)) encoding an extended-spectrum class A beta-lactamase related to the Bacteroides cephalosporinases and the VEB-1 and PER beta-lactamases. Antimicrobial Agents and Chemotherapy, 43 (9), 2193-9. doi:10.1128/aac.43.9.2193
Peer Reviewed verified by ORBi

Swaren, P., Maveyraud, L., Raquet, X., Cabantous, S., Duez, C., Pédelacq, J.-D., Maryotte-Boyer, S., Mourey, L., Labia, R., Nicolas-Chanoine, M.-H., Nordmann, P., Frère, J.-M., & Samama, J.-P. (09 October 1998). X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity. Journal of Biological Chemistry, 273 (41), 26714-26721. doi:10.1074/jbc.273.41.26714
Peer Reviewed verified by ORBi

Georis, J., De Lemos Esteves, F., Lamotte-Brasseur, J., Goossens, E., Bougnet, V., Giannotta, F., Granier, B., & Frère, J.-M. (May 1998). Structural basis and molecular study for the thermostability of the G/11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38 [Poster presentation]. Bioforum, Liège, Belgium.

Matagne, A., Lamotte-Brasseur, J., & Frère, J.-M. (01 March 1998). Catalytic Properties of Class a Beta-Lactamases: Efficiency and Diversity. Biochemical Journal, 330 ((Pt 2)), 581-98. doi:10.1042/bj3300581
Peer Reviewed verified by ORBi

Carfi, A., Duee, E., Paul-Soto, R., Galleni, M., Frère, J.-M., & Dideberg, O. (1998). X-ray structure of the ZnII beta-lactamase from Bacteroides fragilis in an orthorhombic crystal form. Acta Crystallographica. Section D, Biological Crystallography, 54 (Pt 1), 45-57. doi:10.1107/s090744499700927x
Peer Reviewed verified by ORBi

Pierrard, A., Ledent, P., Docquier, J.-D., Feller, G., Gerday, C., & Frère, J.-M. (1998). Inducible class C beta-lactamases produced by psychrophilic bacteria. FEMS Microbiology Letters, 161, 311-315. doi:10.1016/S0378-1097(98)00088-3
Peer Reviewed verified by ORBi

Vanhove, M., Lejeune, A., GUILLAUME, G., Virden, R., Pain, R. H., Schmid, F. X., & Frère, J.-M. (1998). A collapsed intermediate with nonnative packing of hydrophobic residues in the folding of TEM-1 beta-lactamase. Biochemistry, 37 (7), 1941-1950. doi:10.1021/bi972143c
Peer Reviewed verified by ORBi

Philippon, A., Dusart, J., Joris, B., & Frère, J.-M. (1998). The diversity, structure and regulation of beta-lactamases. Cellular and Molecular Life Sciences, 54 (4), 341-6. doi:10.1007/s000180050161
Peer Reviewed verified by ORBi

Charlier, P., Coyette, J., Dehareng, D., Dive, G., Duez, C., Dusart, J., Fonzé, E., Fraipont, C., Frère, J.-M., Galleni, M., Goffin, C., Joris, B., Lamotte-Brasseur, J., & Nguyen-Distèche, M. (1998). Résistance bactérienne aux beta-lactamines. MS. Medecine Sciences, 14 (5), 544-555. doi:10.4267/10608/1092
Peer Reviewed verified by ORBi

Rossolini, G. M., Franceschini, N., Riccio, M. L., Mercuri, P., Perilli, M., Galleni, M., Frère, J.-M., & Amicosante, G. (1998). Characterization and sequence of the Chryseobacterium (Flavobacterium) meningosepticum carbapenemase: a new molecular class B beta-lactamase showing a broad substrate profile. Biochemical Journal, 332 ( Pt 1), 145-52. doi:10.1042/bj3320145
Peer Reviewed verified by ORBi

Paul-Soto, R., Hernandez-Valladares, M., Galleni, M., Bauer, R., Zeppezauer, M., Frère, J.-M., & Adolph, H. W. (1998). Mono- and binuclear Zn-beta-lactamase from Bacteroides fragilis: catalytic and structural roles of the zinc ions. FEBS Letters, 438 (1-2), 137-40. doi:10.1016/S0014-5793(98)01289-7
Peer Reviewed verified by ORBi

Zhao, G., Duez, C., Forceille, C., Rhazi, N., Klein, D., Ghuysen, J.-M., Frère, J.-M., & Lepage, S. (15 October 1997). Site-Directed Mutagenesis of the Actinomadura R39 DD-Peptidase. Biochemical Journal, 327 (2), 377-381. doi:10.1042/bj3270377
Peer Reviewed verified by ORBi

Adam, M., Fraipont, C., Rhazi, N., Nguyen-Disteche, M., Lakaye, B., Frère, J.-M., Devreese, B., Van Beeumen, J., van Heijenoort, Y., van Heijenoort, J., & Ghuysen, J.-M. (October 1997). The Bimodular G57-V577 Polypeptide Chain of the Class B Penicillin-Binding Protein 3 of Escherichia Coli Catalyzes Peptide Bond Formation from Thiolesters and Does Not Catalyze Glycan Chain Polymerization from the Lipid II Intermediate. Journal of Bacteriology, 179 (19), 6005-6009. doi:10.1128/jb.179.19.6005-6009.1997
Peer Reviewed verified by ORBi

Hernandez Valladares, M., Felici, A., Weber, G., Adolph, H. W., Zeppezauer, M., Rossolini, G. M., Amicosante, G., Frère, J.-M., & Galleni, M. (23 September 1997). Zn(Ii) Dependence of the Aeromonas Hydrophila Ae036 Metallo-Beta-Lactamase Activity and Stability. Biochemistry, 36 (38), 11534-41. doi:10.1021/bi971056h
Peer Reviewed verified by ORBi

Quinting, B., Reyrat, J. M., Monnaie, D., Amicosante, G., Pelicic, V., Gicquel, B., Frère, J.-M., & Galleni, M. (14 April 1997). Contribution of Beta-Lactamase Production to the Resistance of Mycobacteria to Beta-Lactam Antibiotics. FEBS Letters, 406 (3), 275-8. doi:10.1016/S0014-5793(97)00286-X
Peer Reviewed verified by ORBi

Quinting, B., Galleni, M., Timm, J., Gicquel, B., Amicosante, G., & Frère, J.-M. (01 April 1997). Purification and Properties of the Mycobacterium Smegmatis Mc(2)155 Beta-Lactamase. FEMS Microbiology Letters, 149 (1), 11-5. doi:10.1016/S0378-1097(97)00041-4
Peer Reviewed verified by ORBi

Felici, A., Perilli, M., Franceschini, N., Rossolini, G. M., Galleni, M., Frère, J.-M., Oratore, A., & Amicosante, G. (1997). Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases. Antimicrobial Agents and Chemotherapy, 41 (4), 866-8. doi:10.1128/aac.41.4.866
Peer Reviewed verified by ORBi

Guillaume, G., Vanhove, M., Lamotte-Brasseur, J., Ledent, P., Jamin, M., Joris, B., & Frère, J.-M. (1997). Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies. Journal of Biological Chemistry, 272 (9), 5438-44. doi:10.1074/jbc.272.9.5438
Peer Reviewed verified by ORBi

Ledent, P., Duez, C., Vanhove, M., Lejeune, A., Fonze, E., Charlier, P., Rhazi-Filali, F., Thamm, I., Guillaume, G., Samyn, B., Devreese, B., Van Beeumen, J., Lamotte-Brasseur, J., & Frère, J.-M. (1997). Unexpected Influence of a C-Terminal-Fused His-Tag on the Processing of an Enzyme and on the Kinetic and Folding Parameters. FEBS Letters, 413 (2), 194-196. doi:10.1016/S0014-5793(97)00908-3
Peer Reviewed verified by ORBi

Hardt, K., Joris, B., Lepage, S., Brasseur, R., Lampen, J. O., Frère, J.-M., Fink, A. L., & Ghuysen, J.-M. (1997). The Penicillin sensory transducer, blar, involved in the inducibility of beta-lactamase synthesis in bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle. Molecular Microbiology, 23 (5), 935-944. doi:10.1046/j.1365-2958.1997.2761642.x
Peer Reviewed verified by ORBi

Perez-Llarena, F., Martin, J. F., Galleni, M., Coque, J. J., Fuente, J. L., Frère, J.-M., & Liras, P. (1997). The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity. Journal of Bacteriology, 179 (19), 6035-40. doi:10.1128/jb.179.19.6035-6040.1997
Peer Reviewed verified by ORBi

Hernandez Villadares, M., Galleni, M., Frère, J.-M., Felici, A., Perilli, M., Franceschini, N., Rossolini, G. M., Oratore, A., & Amicosante, G. (1996). Overproduction and purification of the Aeromonas hydrophila CphA metallo-beta-lactamase expressed in Escherichia coli. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 2 (2), 253-6. doi:10.1089/mdr.1996.2.253
Peer Reviewed verified by ORBi

Damblon, C., Raquet, X., Lian, L. Y., Lamotte, J., Fonze, E., Charlier, P., Roberts, G. C., & Frère, J.-M. (1996). The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme. Proceedings of the National Academy of Sciences of the United States of America, 93 (5), 1747-52. doi:10.1073/pnas.93.5.1747
Peer Reviewed verified by ORBi

Mainfroid, V., Terpstra, P., Beauregard, M., Frère, J.-M., Mande, S. C., Hol, W. G., Martial, J., & Goraj, K. (1996). Three hTIM mutants that provide new insights on why TIM is a dimer. Journal of Molecular Biology, 257 (2), 441-56. doi:10.1006/jmbi.1996.0174
Peer Reviewed verified by ORBi

Galleni, M., Lamotte-Brasseur, J., Raquet, X., Dubus, A., Monnaie, D., Knox, J. R., & Frère, J.-M. (11 May 1995). The Enigmatic Catalytic Mechanism of Active-Site Serine Beta-Lactamases. Biochemical Pharmacology, 49 (9), 1171-8. doi:10.1016/0006-2952(94)00502-D
Peer Reviewed verified by ORBi

Lepage, S., Lakaye, B., Galleni, M., Thamm, I., Crine, M., Groslambert, S., & Frère, J.-M. (April 1995). Saturation of Penicillin-Binding Protein 1 by Beta-Lactam Antibiotics in Growing Cells of Bacillus Licheniformis. Molecular Microbiology, 16 (2), 365-72. doi:10.1111/j.1365-2958.1995.tb02308.x
Peer Reviewed verified by ORBi

Jacobs, C., Joris, B., Jamin, M., Klarsov, K., Van Beeumen, J., Mengin-Lecreulx, D., van Heijenoort, J., Park, J. T., Normark, S., & Frère, J.-M. (February 1995). Ampd, Essential for Both Beta-Lactamase Regulation and Cell Wall Recycling, Is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase. Molecular Microbiology, 15 (3), 553-9. doi:10.1111/j.1365-2958.1995.tb02268.x
Peer Reviewed verified by ORBi

Galleni, M., Raquet, X., Lamotte-Brasseur, J., Fonze, E., Amicosante, G., & Frère, J.-M. (February 1995). Dd-Peptidases and Beta-Lactamases: Catalytic Mechanisms and Specificities. Journal of Chemotherapy, 7 (1), 3-7. doi:10.1179/joc.1995.7.1.3
Peer Reviewed verified by ORBi

Matagne, A., & Frère, J.-M. (19 January 1995). Contribution of Mutant Analysis to the Understanding of Enzyme Catalysis: The Case of Class a Beta-Lactamases. Biochimica et Biophysica Acta, 1246 (2), 109-27. doi:10.1016/0167-4838(94)00177-I
Peer Reviewed verified by ORBi

Damblon, C., Ledent, P., Zhao, G. H., Jamin, M., Dubus, A., Vanhove, M.-L., Raquet, X., Christiaens, L., & Frère, J.-M. (1995). Thiolester substrates of DD-peptidases and beta-lactamases. Letters in Peptide Science, 2 (3-4), 212-216. doi:10.1007/BF00119156
Peer Reviewed verified by ORBi

Grandchamps, J., Nguyen-Distèche, M., Damblon, C., Frère, J.-M., & Ghuysen, J.-M. (1995). Streptomyces K15 active-site serine DD-transpeptidase: specificity profile for peptide, thiol ester and ester carbonyl donors and pathways of the transfer reactions. Biochemical Journal, 307 (Pt 2), 335-339. doi:10.1042/bj3070335
Peer Reviewed verified by ORBi

Carfi, A., Pares, S., Duée, E., Galleni, M., Duez, C., Frère, J.-M., & Dideberg, O. (1995). The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold. EMBO Journal, 14 (20), 4914-4921. doi:10.1002/j.1460-2075.1995.tb00174.x
Peer Reviewed verified by ORBi

Matagne, A., Ledent, P., Monnaie, D., Felici, A., Jamin, M., Raquet, X., Galleni, M., Klein, D., Francois, I., & Frère, J.-M. (January 1995). Kinetic Study of Interaction between Brl 42715, Beta-Lactamases, and D-Alanyl-D-Alanine Peptidases. Antimicrobial Agents and Chemotherapy, 39 (1), 227-31. doi:10.1128/aac.39.1.227
Peer Reviewed verified by ORBi

Fonze, E., Charlier, P., To'th, Y., Vermeire, M., Raquet, X., Dubus, A., & Frère, J.-M. (1995). TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant. Acta Crystallographica. Section D, Biological Crystallography, 51 (Pt 5), 682-94. doi:10.1107/S0907444994014496
Peer Reviewed verified by ORBi

Lepage, S., Galleni, M., Lakaye, B., Joris, B., Thamm, I., & Frère, J.-M. (1995). Kinetic properties of the Bacillus licheniformis Penicillin-binding proteins. Biochemical Journal, 309, 49-53. doi:10.1042/bj3090049
Peer Reviewed verified by ORBi

Damblon, C., Zhao, G. H., Jamin, M., Ledent, P., Dubus, A., Vanhove, M.-L., Raquet, X., Christiaens, L., & Frère, J.-M. (1995). Breakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates. Biochemical Journal, 309 ( Pt 2), 431-6. doi:10.1042/bj3090431
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Duez, C., Piron-Fraipont, C., Joris, B., Dusart, J., Urdea, M.-S., Martial, J., Frère, J.-M., & Ghuysen, J.-M. (15 September 1994). Erratum for : primary structure of the streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene. European Journal of Biochemistry, 224 (3), 1079. doi:10.1111/j.1432-1033.1994.01079.x
Peer Reviewed verified by ORBi

Fanuel, L., Granier, B., Wilkin, J.-M., Bellefroid-Bourguignon, C., Joris, B., Knowles, J., Komives, E., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (29 August 1994). The Precursor of the Streptomyces R61 Dd-Peptidase Containing a C-Terminal Extension Is Inactive. FEBS Letters, 351 (1), 49-52. doi:10.1016/0014-5793(94)00822-1
Peer Reviewed verified by ORBi

Galleni, M., Franceschini, N., Quinting, B., Fattorini, L., Orefici, G., Oratore, A., Frère, J.-M., & Amicosante, G. (July 1994). Use of the Chromosomal Class a Beta-Lactamase of Mycobacterium Fortuitum D316 to Study Potentially Poor Substrates and Inhibitory Beta-Lactam Compounds. Antimicrobial Agents and Chemotherapy, 38 (7), 1608-14. doi:10.1128/AAC.38.7.1608
Peer Reviewed verified by ORBi

Timm, J., Perilli, M. G., Duez, C., Trias, J., Orefici, G., Fattorini, L., Amicosante, G., Oratore, A., Joris, B., & Frère, J.-M. (1994). Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer. Molecular Microbiology, 12 (3), 491-504. doi:10.1111/j.1365-2958.1994.tb01037.x
Peer Reviewed verified by ORBi

Joris, B., Galleni, M., Frère, J.-M., & Labia, R. (1994). Analysis of the penA gene of Pseudomonas cepacia 249. Antimicrobial Agents and Chemotherapy, 38 (2), 407-8. doi:10.1128/AAC.38.2.407
Peer Reviewed verified by ORBi

Jamin, M., Damblon, C., Bauduin-Misselyn, A. M., Durant, F., Roberts, G. C., Charlier, P., Llabres, G., & Frère, J.-M. (1994). Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase. Biochemical Journal, 301 ( Pt 1), 199-203. doi:10.1042/bj3010199
Peer Reviewed verified by ORBi

STRYNADKA, N. C. J., JENSEN, S. E., JOHNS, K., BLANCHARD, H., PAGE, M., Matagne, A., Frère, J.-M., & JAMES, M. N. G. (1994). STRUCTURAL AND KINETIC CHARACTERIZATION OF A BETA-LACTAMASE-INHIBITOR PROTEIN. Nature, 368 (6472), 657-660. doi:10.1038/368657a0
Peer Reviewed verified by ORBi

Granier, B., Jamin, M., Adam, M., Galleni, M., Lakaye, B., Zorzi, W., Grandchamps, J., Wilkin, J.-M., Fraipont, C., Joris, B., Duez, C., Nguyen-Distèche, M., Coyette, J., Leyh-Bouille, M., Dusart, J., Christians, L., Frère, J.-M., & Ghuysen, J.-M. (1994). Serine-Type D-Ala-D-Ala Peptidases and Penicillin-Binding Proteins. Methods in Enzymology, 244, 249-266. doi:10.1016/0076-6879(94)44021-2
Peer Reviewed verified by ORBi

Lamotte, J., Knox, J., Kelly, J. A., Charlier, P., Fonze, E., Dideberg, O., & Frère, J.-M. (1994). The structures and catalytic mechanisms of active-site serine beta-lactamases. Biotechnology and Genetic Engineering Reviews, 12, 189-230. doi:10.1080/02648725.1994.10647912
Peer Reviewed verified by ORBi

Lakaye, B., Damblon, C., Jamin, M., Galleni, M., Lepage, S., Joris, B., Marchand-Brynaert, J., Frydrychh, C., & Frère, J.-M. (1994). Synthesis, purification and kinetic properties of fluorescein-labelled penicillins. Biochemical Journal, 300, 141-145. doi:10.1042/bj3000141
Peer Reviewed verified by ORBi

Wilkin, J. M., Dubus, A., Joris, B., & Frère, J.-M. (1994). The mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase. Biochemical Journal, 301 ( Pt 2), 477-83. doi:10.1042/bj3010477
Peer Reviewed verified by ORBi

Datz, M., Joris, B., Azab, E. A., Galleni, M., Van Beeumen, J., Frère, J.-M., & Martin, H. H. (1994). A common system controls the induction of very different genes. The class-A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-lactamase. European Journal of Biochemistry, 226 (1), 149-57. doi:10.1111/j.1432-1033.1994.tb20036.x
Peer Reviewed verified by ORBi

Matagne, A., Ghuysen, M. F., & Frère, J.-M. (01 November 1993). Interactions between Active-Site-Serine Beta-Lactamases and Mechanism-Based Inactivators: A Kinetic Study and an Overview. Biochemical Journal, 295 ((Pt 3)), 705-711. doi:10.1042/bj2950705
Peer Reviewed verified by ORBi

Matagne, A., Lamotte-Brasseur, J., & Frère, J.-M. (01 October 1993). Interactions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies. European Journal of Biochemistry, 217 (1), 61-67. doi:10.1111/j.1432-1033.1993.tb18218.x
Peer Reviewed verified by ORBi

Matagne, A., Lamotte-Brasseur, J., Dive, G., Knox, J. R., & Frère, J.-M. (01 August 1993). Interactions between Active-Site-Serine Beta-Lactamases and Compounds Bearing a Methoxy Side Chain on the Alpha-Face of the Beta-Lactam Ring: Kinetic and Molecular Modelling Studies. Biochemical Journal, 293 ((Pt 3)), 607-611. doi:10.1042/bj2930607
Peer Reviewed verified by ORBi

Wilkin, J.-M., Jamin, M., Damblon, C., Zhao, G.-H., Joris, B., Duez, C., & Frère, J.-M. (15 April 1993). The Mechanism of Action of DD-Peptidases: The Role of Tyrosine-159 in the Streptomyces R61 DD-Peptidase. Biochemical Journal, 291 (Part 2), 537-544. doi:10.1042/bj2910537
Peer Reviewed verified by ORBi

Galleni, M., Lakaye, B., Lepage, S., Jamin, M., Thamm, I., Joris, B., & Frère, J.-M. (01 April 1993). A New, Highly Sensitive Method for the Detection and Quantification of Penicillin-Binding Proteins. Biochemical Journal, 291 ((Pt 1)), 19-21. doi:10.1042/bj2910019
Peer Reviewed verified by ORBi

JAMIN, M., Damblon, C., MILLIER, S., HAKENBECK, R., & Frère, J.-M. (1993). PENICILLIN-BINDING PROTEIN 2X OF STREPTOCOCCUS-PNEUMONIAE - ENZYMATIC-ACTIVITIES AND INTERACTIONS WITH BETA-LACTAMS. Biochemical Journal, 292 (Part 3), 735-741. doi:10.1042/bj2920735
Peer Reviewed verified by ORBi

Wilkin, J. M., Jamin, M., Joris, B., & Frère, J.-M. (1993). Mechanism of action of DD-peptidases: role of asparagine-161 in the Streptomyces R61 DD-peptidase. Biochemical Journal, 293 ( Pt 1), 195-201. doi:10.1042/bj2930195
Peer Reviewed verified by ORBi

Felici, A., Amicosante, G., Oratore, A., Strom, R., Ledent, P., Joris, B., Fanuel, L., & Frère, J.-M. (1993). An overview of the kinetic parameters of class B beta-lactamases. Biochemical Journal, 291 ( Pt 1), 151-5. doi:10.1042/bj2910151
Peer Reviewed verified by ORBi

Ledent, P., Raquet, X., Joris, B., Van Beeumen, J., & Frère, J.-M. (1993). A comparative study of class-D beta-lactamases. Biochemical Journal, 292 ( Pt 2), 555-62. doi:10.1042/bj2920555
Peer Reviewed verified by ORBi

Franceschini, N., Galleni, M., Frère, J.-M., Oratore, A., & Amicosante, G. (1993). A class-A beta-lactamase from Pseudomonas stutzeri that is highly active against monobactams and cefotaxime. Biochemical Journal, 292 ( Pt 3), 697-700. doi:10.1042/bj2920697
Peer Reviewed verified by ORBi

Hadonou, A. M., Wilkin, J.-M., Varetto, L., Joris, B., Lamotte-Brasseur, J., Klein, D., Duez, C., Ghuysen, J.-M., & Frère, J.-M. (01 July 1992). Site-Directed Mutagenesis of the Streptomyces R61 Dd-Peptidase. Catalytic Function of the Conserved Residues around the Active Site and a Comparison with Class-a and Class-C Beta-Lactamases. European Journal of Biochemistry, 207 (1), 97-102. doi:10.1111/j.1432-1033.1992.tb17025.x
Peer Reviewed verified by ORBi

Bourguignon-Bellefroid, C., Joris, B., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (01 April 1992). Point Mutations of Two Arginine Residues in the Streptomyces R61 Dd-Peptidase. Biochemical Journal, 283 (1), 123-128. doi:10.1042/bj2830123
Peer Reviewed verified by ORBi

Granier, B., Duez, C., Englebert, S., Dusart, J., Dideberg, O., Van Beeumen, J., Frère, J.-M., Ghuysen, J.-M., & Lepage, S. (15 March 1992). Primary and Predicted Secondary Structures of the Actinomadura R39 Extracellular DD-Peptidase, a Penicillin-Binding Protein (PBP) Related to the Escherichia coli PBP4. Biochemical Journal, 282 (Pt 3), 781-788. doi:10.1042/bj2820781
Peer Reviewed verified by ORBi

Bourguignon-Bellefroid, C., Wilkin, J.-M., Joris, B., Aplin, R. T., Houssier, C., Prendergast, F. G., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (01 March 1992). Importance of the Two Tryptophan Residues in the Streptomyces R61 Exocellular Dd-Peptidase. Biochemical Journal, 282 (Pt 2), 361-367. doi:10.1042/bj2820361
Peer Reviewed verified by ORBi

Hadonou, A. M., Jamin, M., Adam, M., Joris, B., Dusart, J., Ghuysen, J.-M., & Frère, J.-M. (01 March 1992). Importance of the His-298 Residue in the Catalytic Mechanism of the Streptomyces R61 Extracellular Dd-Peptidase. Biochemical Journal, 282 (Pt 2), 495-500. doi:10.1042/bj2820495
Peer Reviewed verified by ORBi

Lamotte-Brasseur, J., Jacob-Dubuisson, F., Dive, G., Frère, J.-M., & Ghuysen, J.-M. (10 February 1992). Streptomyces albus G serine β-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes. Biochemical Journal, 282 (Pt 1), 189-195. doi:10.1042/bj2820189
Peer Reviewed verified by ORBi

Granier, B., Duez, C., Lepage, S., Englebert, S., Dusart, J., Dideberg, O., Van Baumeen, J., Frère, J.-M., & Ghuysen, J.-M. (1992). Correction: Primary and predicted secondary structure of the actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the escherichia coli PBP4 (Biochemical Journal(1992)282(786)). Biochemical Journal, 282 (Part 3), 981-982. doi:10.1042/bj2860981c
Peer Reviewed verified by ORBi

Pirotte, B., Dive, G., Delarge, J., Masereel, B., Dupont, L., Thunus, L., Schynts, M., Coyette, J., & Frère, J.-M. (1992). Synthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques b-lactamiques. European Journal of Medicinal Chemistry, 27 (3), 193-205. doi:10.1016/0223-5234(92)90003-J
Peer Reviewed verified by ORBi

Matagne, A., Joris, B., & Frère, J.-M. (01 December 1991). Anomalous Behaviour of a Protein During Sds/Page Corrected by Chemical Modification of Carboxylic Groups. Biochemical Journal, 280 ((Pt 2)), 553-6. doi:10.1042/bj2800553
Peer Reviewed verified by ORBi

Joris, B., Ledent, P., Dideberg, O., Fonze, E., Lamotte-Brasseur, J., Kelly, J. A., Ghuysen, J.-M., & Frère, J.-M. (November 1991). Comparison of the Sequences of Class a β-lactamase and of the Secondary Structure Elements of Penicillin-Recognizing Proteins. Antimicrobial Agents and Chemotherapy, 35 (11), 2294-2301. doi:10.1128/AAC.35.11.2294
Peer Reviewed verified by ORBi

Lamotte-Brasseur, J., Dive, G., Dideberg, O., Charlier, P., Frère, J.-M., & Ghuysen, J.-M. (01 October 1991). Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G. Biochemical Journal, 279 (Pt 1), 213-221. doi:10.1042/bj2790213
Peer Reviewed verified by ORBi

Varetto, L., De Meester, F., Monnaie, D., Marchand-Brynaert, J., Dive, G., Jacob, F., & Frère, J.-M. (15 September 1991). The Importance of the Negative Charge of Beta-Lactam Compounds in the Interactions with Active-Site Serine Dd-Peptidases and Beta-Lactamases. Biochemical Journal, 278 (Pt 3), 801-807. doi:10.1042/bj2780801
Peer Reviewed verified by ORBi

Jacob, F., Joris, B., & Frère, J.-M. (01 August 1991). Active-Site Serine Mutants of the Streptomyces Albus G Beta-Lactamase. Biochemical Journal, 277 ((Pt 3)), 647-52. doi:10.1042/bj2770647
Peer Reviewed verified by ORBi

Ambler, R. P., Coulson, A. F. W., Frère, J.-M., Ghuysen, J.-M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., & Waley, S. G. (15 May 1991). A standard numbering scheme for the class A beta-lactamases. Biochemical Journal, 276 (Pt 1), 269-270. doi:10.1042/bj2760269
Peer Reviewed verified by ORBi

Matagne, A., Joris, B., Van Beeumen, J., & Frère, J.-M. (01 February 1991). Ragged N-Termini and Other Variants of Class a Beta-Lactamases Analysed by Chromatofocusing. Biochemical Journal, 273 (273), 503-10. doi:10.1042/bj2730503
Peer Reviewed verified by ORBi

JAMIN, M., Adam, M., Damblon, C., Christiaens, L., & Frère, J.-M. (1991). ACCUMULATION OF ACYL-ENZYME IN DD-PEPTIDASE-CATALYZED REACTIONS WITH ANALOGS OF PEPTIDE-SUBSTRATES. Biochemical Journal, 280 (Part 2), 499-506. doi:10.1042/bj2800499
Peer Reviewed verified by ORBi

Frère, J.-M., Joris, B., Granier, B., Matagne, A., Ackerman, F., & Bourguignon-Bellefroid, C. (1991). Diversity of the Mechanisms of Resistance to Beta-Lactam Antibiotics. Research in Microbiology, 142 (6, Jul-Aug), 705-10. doi:10.1016/0923-2508(91)90084-N
Peer Reviewed verified by ORBi

Adam, M., Damblon, C., Jamin, M., Zorzi, W., Dusart, V., Galleni, M., El Kharroubi, A., Piras, G., Spratt, B. G., Keck, W., Coyette, J., Ghuysen, J.-M., NGuyen-Distèche, M., & Frère, J.-M. (1991). Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochemical Journal, 279 (Part 2), 601-604. doi:10.1042/bj2790601
Peer Reviewed verified by ORBi

Frère, J.-M., Joris, B., Jacob, F., Matagne, A., Monnaie, D., Jamin, M., Hadonou, M., Bourguignon-Bellefroid, C., Varetto, L., Wilkin, J.-M., Dubus, A., Damblon, C., Adam, M., Ledent, P., De Meester, F., & Galleni, M. (1991). Mechanism of action of β-lactamases and DD-peptidases. In U. K. Pandit & F. C. Alderweireldt (Eds.), Bioorganic Chemistry in Healthcare and Technology (pp. 161-170). New York, United States - New York: Plenum Press.
Peer reviewed

BRANNIGAN, J., Matagne, A., Jacob, F., Damblon, C., Joris, B., KLEIN, D., SPRATT, B. G., & Frère, J.-M. (1991). THE MUTATION LYS234HIS YIELDS A CLASS-A BETA-LACTAMASE WITH A NOVEL PH-DEPENDENCE. Biochemical Journal, 278 (Part 3), 673-678. doi:10.1042/bj2780673
Peer Reviewed verified by ORBi

Perilli, M., Franceschini, N., Segatore, B., Amicosante, G., Oratore, A., Duez, C., Joris, B., & Frère, J.-M. (1991). Cloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus. FEMS Microbiology Letters, 83, 79-84. doi:10.1111/j.1574-6968.1991.tb04393.x
Peer Reviewed verified by ORBi

Pirotte, B., Delarge, J., Coyette, J., & Frère, J.-M. (1991). Antibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to β-lactam antibiotics. Journal of Antibiotics, 44, 844-853. doi:10.7164/antibiotics.44.844
Peer Reviewed verified by ORBi

Jacob, F., Joris, B., Lepage, S., Dusart, J., & Frère, J.-M. (15 October 1990). Role of the Conserved Amino Acids of the 'Sdn' Loop (Ser130, Asp131 and Asn132) in a Class a Beta-Lactamase Studied by Site-Directed Mutagenesis. Biochemical Journal, 271 (2), 399-406. doi:10.1042/bj2710399
Peer Reviewed verified by ORBi

Jacob, F., Joris, B., Dideberg, O., Dusart, J., Ghuysen, J.-M., & Frère, J.-M. (October 1990). Engineering a Novel β-Lactamase by a Single Point Mutation. Protein Engineering, 4 (1), 79-86. doi:10.1093/protein/4.1.79
Peer Reviewed verified by ORBi

Matagne, A., Misselyn-Bauduin, A. M., Joris, B., Erpicum, T., Granier, B., & Frère, J.-M. (01 January 1990). The Diversity of the Catalytic Properties of Class a Beta-Lactamases. Biochemical Journal, 265 (1), 131-46. doi:10.1042/bj2650131
Peer Reviewed verified by ORBi

Adam, M., Damblon, C., PLAITIN, B., Christiaens, L., & Frère, J.-M. (1990). CHROMOGENIC DEPSIPEPTIDE SUBSTRATES FOR BETA-LACTAMASES AND PENICILLIN-SENSITIVE DD-PEPTIDASES. Biochemical Journal, 270 (2), 525-529. doi:10.1042/bj2700525
Peer Reviewed verified by ORBi

Moews, P. C., Knox, J. R., Dideberg, O., Charlier, P., & Frère, J.-M. (1990). Beta-lactamase of Bacillus licheniformis 749/C at 2 A resolution. Proteins, 7 (2), 156-71. doi:10.1002/prot.340070205
Peer Reviewed verified by ORBi

Houba, S., Willem, S., Duez, C., Molitor, C., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (December 1989). Nucleotide sequence of the gene encoding the active-site serine β-lactamase from Actinomadura R39. FEMS Microbiology Letters, 65 (3), 241-246. doi:10.1111/j.1574-6968.1989.tb03667.x
Peer Reviewed verified by ORBi

Frère, J.-M., Joris, B., Crine, M., & Martin, H. H. (01 May 1989). Quantitative Relationship between Sensitivity to Beta-Lactam Antibiotics and Beta-Lactamase Production in Gram-Negative Bacteria--II. Non-Steady-State Treatment and Progress Curves. Biochemical Pharmacology, 38 (9), 1427-33. doi:10.1016/0006-2952(89)90181-0
Peer Reviewed verified by ORBi

De Meester, F., Matagne, A., Dive, G., & Frère, J.-M. (01 January 1989). Unexpected Influence of Ionic Strength on Branched-Pathway Interactions between Beta-Lactamases and Beta-Halogenopenicillanates. Biochemical Journal, 257 (1), 245-9. doi:10.1042/bj2570245
Peer Reviewed verified by ORBi

Kelly, J. A., Knox, J. R., Zhao, H. C., Frère, J.-M., & Ghuysen, J.-M. (1989). Crystallographic mapping of β-lactams bound to a D-alanyl-D-alanine peptidase target enzyme. Journal of Molecular Biology, 209 (2), 281-295. doi:10.1016/0022-2836(89)90277-5
Peer Reviewed verified by ORBi

Fraipont, C., Duez, C., Matagne, A., Molitor, C., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (1989). Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular β-lactamase of Actinomadura R39. Biochemical Journal, 262 (3), 849-854. doi:10.1042/bj2620849
Peer Reviewed verified by ORBi

Galleni, M., Amicosante, G., & Frère, J.-M. (01 October 1988). A Survey of the Kinetic Parameters of Class C Beta-Lactamases. Cephalosporins and Other Beta-Lactam Compounds. Biochemical Journal, 255 (1), 123-9. doi:10.1042/bj2550123
Peer Reviewed verified by ORBi

Galleni, M., & Frère, J.-M. (01 October 1988). A Survey of the Kinetic Parameters of Class C Beta-Lactamases. Penicillins. Biochemical Journal, 255 (1), 119-22. doi:10.1042/bj2550119
Peer Reviewed verified by ORBi

Galleni, M., Lindberg, F., Normark, S., Cole, S., Honore, N., Joris, B., & Frère, J.-M. (15 March 1988). Sequence and Comparative Analysis of Three Enterobacter Cloacae Ampc Beta-Lactamase Genes and Their Products. Biochemical Journal, 250 (3), 753-60. doi:10.1042/bj2500753
Peer Reviewed verified by ORBi

Joris, B., Ghuysen, J.-M., Dive, G., Renard, A., Dideberg, O., Charlier, P., Frère, J.-M., Kelly, J. A., Boyington, J., Moews, P. C., & Knox, J. (01 March 1988). The Active-Site-Serine Penicillin-Recognizing Enzymes as Members of the Streptomyces R61 Dd-Peptidase Family. Biochemical Journal, 250 (2), 313-324. doi:10.1042/bj2500313
Peer Reviewed verified by ORBi

Kelly, J. A., Knox, J. R., Moews, P. C., Frère, J.-M., & Ghuysen, J.-M. (01 March 1988). Using X-ray diffraction results and computer graphics to design beta-lactams. Kansenshogaku zasshi, 62 Suppl, 182-191.
Peer Reviewed verified by ORBi

Frère, J.-M., & Joris, B. (1988). Beta-Lactamase-induced resistance. In P. Actor, L. Daneo-Moore, M. L. Higgins, M. R. J. Salton, ... G. D. Shockman (Eds.), Antibiotic Inhibition of Bacterial Cell Surface Assembly and Function (pp. 468-480). Washington,D.C., United States: American Society for Microbiology.

Frère, J.-M., & Joris, B. (1988). Beta-Lactamases as the Main Resistance Factor to Penicillin-Related Antibiotics. Annales de Biologie Clinique, 46 (2), 151-6.
Peer Reviewed verified by ORBi

Lenzini, M. V., Ishihara, H., Dusart, J., Ogawara, H., Joris, B., Van Beeumen, J., Frère, J.-M., & Ghuysen, J.-M. (1988). Nucleotide sequence of the gene encoding the active-site serine β-lactamase from Streptomyces cacaoi. FEMS Microbiology Letters, 49 (3), 371-376. doi:10.1111/j.1574-6968.1988.tb02760.x
Peer Reviewed verified by ORBi

Frère, J.-M., Joris, B., Dideberg, O., Charlier, P., & Ghuysen, J.-M. (1988). Penicillin-recognizing enzymes. Biochemical Society Transactions, 16 (6), 934-938. doi:10.1042/bst0160934
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Amicosante, G., Oratore, A., Joris, B., Galleni, M., Frère, J.-M., & Van Beeumen, J. (1988). Chromosome-encoded beta-lactamases of Citrobacter diversus. Interaction with beta-iodopenicillanate and labelling of the active site. Biochemical Journal, 254 (3), 891-3. doi:10.1042/bj2540891
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Amicosante, G., Oratore, A., Franceschini, N., Maccarrone, M., Strom, R., Galleni, M., & Frère, J.-M. (1988). Citrobacter diversus ULA-27 beta-lactamases. Improved purification and general properties. Biochemical Journal, 254 (3), 885-90. doi:10.1042/bj2540885
Peer Reviewed verified by ORBi

Frère, J.-M., Joris, B., Varetto, L., & Crine, M. (01 January 1988). Structure-Activity Relationships in the Beta-Lactam Family: An Impossible Dream. Biochemical Pharmacology, 37 (1), 125-32. doi:10.1016/0006-2952(88)90764-2
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Varetto, L., Frère, J.-M., & Ghuysen, J.-M. (10 December 1987). The importance of the negative charge of β-lactam compounds for the inactivation of the active-site serine DD-peptidase of Streptomyces R61. FEBS Letters, 225 (1-2), 218-222. doi:10.1016/0014-5793(87)81161-4
Peer Reviewed verified by ORBi

Lenzini, M. V., Nojima, S., Dusart, J., Ogawara, H., Dehottay, P., Frère, J.-M., & Ghuysen, J.-M. (October 1987). Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular β-lactamase from Streptomyces cacaoi. Journal of General Microbiology, 133 (10), 2915-2920.
Peer Reviewed verified by ORBi

Dehottay, P., Dusart, J., De Meester, F., Joris, B., Van Beeumen, J., Erpicum, T., Frère, J.-M., & Ghuysen, J.-M. (15 July 1987). Nucleotide sequence of the gene encoding the Streptomyces albus G β-lactamase precursor. European Journal of Biochemistry, 166 (2), 345-350. doi:10.1111/j.1432-1033.1987.tb13521.x
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Varetto, L., Frère, J.-M., Nguyen-Distèche, M., Ghuysen, J.-M., & Houssier, C. (02 February 1987). The pH dependence of the active-site serine DD-peptidase of Streptomyces R61. European Journal of Biochemistry, 162 (3), 525-531. doi:10.1111/j.1432-1033.1987.tb10671.x
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De Meester, F., Joris, B., Reckinger, G., Bellefroid-Bourguignon, C., Frère, J.-M., & Waley, S. G. (1987). Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases. Biochemical Pharmacology, 36, 2393-2403. doi:10.1016/0006-2952(87)90609-5
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Joris, B., De Meester, F., Galleni, M., Frère, J.-M., & Van Beeumen, J. (1987). The K1 beta-lactamase of Klebsiella pneumoniae. Biochemical Journal, 243 (2), 561-7. doi:10.1042/bj2430561
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Joris, B., Jacques, P., Frère, J.-M., Ghuysen, J.-M., & Van Beeumen, J. (1987). Primary structure of the Streptomyces R61 extracellular DD-peptidase. 2. Amino acid sequence data. European Journal of Biochemistry, 162 (3), 519-524. doi:10.1111/j.1432-1033.1987.tb10670.x
Peer Reviewed verified by ORBi

Demeester, F., Joris, B., Lenzini, M. V., Dehottay, P., Erpicium, T., Dusart, J., Klein, D., Ghuysen, J.-M., Frère, J.-M., & Vanbeeumen, J. (1987). The active sites of the β-lactamases of Streptomyces cacaoi and Streptomyces albus G. Biochemical Journal, 244 (2), 427-432. doi:10.1042/bj2440427
Peer Reviewed verified by ORBi

Dideberg, O., Charlier, P., Wery, J.-P., Dehottay, P., Dusart, J., Erpicum, T., Frère, J.-M., & Ghuysen, J.-M. (1987). The crystal structure of the β-lactamase of Streptomyces albus G at 0.3 nm resolution. Biochemical Journal, 245 (3), 911-913. doi:10.1042/bj2450911
Peer Reviewed verified by ORBi

Duez, C., Fraipont, C., Joris, B., Dusart, J., Urdea, M. S., Martial, J., Frère, J.-M., & Ghuysen, J.-M. (1987). Primary structure of the Streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene. European Journal of Biochemistry, 162, 509-518. doi:10.1111/j.1432-1033.1987.tb10669.x
Peer Reviewed verified by ORBi

Nguyen-Distèche, M., Leyh-Bouille, M., Pirlot, S., Frère, J.-M., & Ghuysen, J.-M. (01 April 1986). Streptomyces K15 DD-peptidase-catalysed reactions with ester and amide carbonyl donors. Biochemical Journal, 235 (1), 167-176. doi:10.1042/bj2350167
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., & Coyette, J. (01 April 1986). Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes. Biochemical Journal, 235 (1), 159-165. doi:10.1042/bj2350159
Peer Reviewed verified by ORBi

Kelly, J. A., Dideberg, O., Charlier, P., Wery, J.-P., Libert, M., Moews, P., Knox, J., Duez, C., Fraipont, C., Joris, B., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (21 March 1986). On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target. Science, 231, 1429-1431. doi:10.1126/science.3082007
Peer Reviewed verified by ORBi

Joris, B., De Meester, F., Galleni, M., Masson, S., Dusart, J., Frère, J.-M., Van Beeumen, J., Bush, K., & Sykes, R. (1986). Properties of a class C beta-lactamase from Serratia marcescens. Biochemical Journal, 239 (3), 581-6. doi:10.1042/bj2390581
Peer Reviewed verified by ORBi

Dehottay, P., Dusart, J., Duez, C., Lenzini, M. V., Martial, J., Frère, J.-M., Ghuysen, J.-M., & Kieser, T. (1986). Cloning and amplified expression in Streptomyces lividans of a gene encoding extracellular β-lactamase from Streptomyces albus G. Gene, 42 (1), 31-36. doi:10.1016/0378-1119(86)90147-2
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Kelly, J. A., Knox, J. R., Moews, P. C., Hite, G. J., Bartolone, J. B., Zhao, H., Joris, B., Frère, J.-M., & Ghuysen, J.-M. (25 May 1985). 2.8-Å Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with β-lactams. Journal of Biological Chemistry, 260 (10), 6449-6458.
Peer Reviewed verified by ORBi

Frère, J.-M., & Joris, B. (1985). Penicillin-sensitive enzymes in peptidoglycan biosynthesis. CRC Critical Reviews in Microbiology, 11, 299-396. doi:10.3109/10408418409105906
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Joris, B., De Meester, F., Galleni, M., Reckinger, G., Coyette, J., Frère, J.-M., & Van Beeumen, J. (1985). The beta-lactamase of Enterobacter cloacae P99. Chemical properties, N-terminal sequence and interaction with 6 beta-halogenopenicillanates. Biochemical Journal, 228 (1), 241-8. doi:10.1042/bj2280241
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Dideberg, O., Libert, M., Frère, J.-M., Charlier, P., Zhao, H., & Knox, J. R. (1985). Crystallization and preliminary X-ray data for the exocellular beta-lactamase of Bacillus licheniformis 749/C. Journal of Molecular Biology, 181 (1), 145-6. doi:10.1016/0022-2836(85)90333-X
Peer Reviewed verified by ORBi

Laurent, G., Durant, F., Frère, J.-M., Klein, D., & Ghuysen, J.-M. (15 March 1984). Des-, syn- and anti-oxyimino-Δ3-cephalosporins. Intrinsic reactivity and reaction with RTEM-2 serine β-lactamase and D-alanyl-D-alanine-cleaving serine and zinc-containing peptidases. Biochemical Journal, 218 (3), 933-937. doi:10.1042/bj2180933
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Frère, J.-M., Klein, D., Kelly, J. A., & Ghuysen, J.-M. (1984). Interaction between monobactams and model D-alanyl-D-alanine-cleaving peptidases. FEMS Microbiology Letters, 21, 213-217. doi:10.1111/j.1574-6968.1984.tb00213.x
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Charlier, P., Dideberg, O., Jamoulle, J.-C., Frère, J.-M., Ghuysen, J.-M., Dive, G., & Lamotte, J. (1984). Active-site-directed inactivators of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G. Biochemical Journal, 219 (3), 763-772. doi:10.1042/bj2190763
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Labischinski, H., Giesbrecht, P., Fischer, E., Barnickel, G., Bradaczek, H., Frère, J.-M., Houssier, C., Charlier, P., Dideberg, O., & Ghuysen, J.-M. (1984). Study of the Zn-containing DD-carboxypeptidase of Streptomyces albus G by small-angle X-ray scattering in solution. European Journal of Biochemistry, 138 (1), 83-87. doi:10.1111/j.1432-1033.1984.tb07884.x
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Joris, B., Dusart, J., Frère, J.-M., van Beeumen, J., Emanuel, E. L., Petursson, S., Gagnon, J., & Waley, S. G. (1984). The active site of the P99 beta-lactamase from Enterobacter cloacae. Biochemical Journal, 223 (1), 271-4. doi:10.1042/bj2230271
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G., & Lamotte-Brasseur, J. (1984). Bacterial cell wall, DD-peptidase and β-lactam antibiotics. Scandinavian Journal of Infectious Diseases, 42, 17-37.
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G., & Lamotte-Brasseur, J. (1984). Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics. Scandinavian Journal of Infectious Diseases, 42, 17-37.
Peer Reviewed verified by ORBi

Joris, B., Van Beeumen, J., Casagrande, F., Gerday, C., Frère, J.-M., & Ghuysen, J.-M. (17 January 1983). The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G. European Journal of Biochemistry, 130 (1), 53-69. doi:10.1111/j.1432-1033.1983.tb07116.x
Peer Reviewed verified by ORBi

Charlier, P., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). The active sites of the D-alanyl-D-alanine-cleaving peptidases. In R. Hakenbeck, J.-V. Höltje, ... H. Labischinski (Eds.), The Target Penicillin : the Murein Sacculus of Bacterial Cell Walls Architecture and Growth : Proceedings (pp. 369-386). Berlin, Germany: Walter de Gruyter & Co.
Peer reviewed

Charlier, P., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). The active site of the D-alanyl-D-Alanine-cleaving peptidase. In R. Hakenbeck, J. V. Höltje, ... H. Labischinski (Eds.), Target of Penicillin: The Murein Sacculus of Bacterial Cell Walls, Architecture and Growth (pp. 369-386). De Gruyter.

Charlier, P., Dideberg, O., Frère, J.-M., Moews, P. C., & Knox, J. R. (1983). Crystallographic data for the beta-lactamase from Enterobacter cloacae P99. Journal of Molecular Biology, 171 (2), 237-8. doi:10.1016/S0022-2836(83)80358-1
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Frère, J.-M., Leyh, B., & Renard, A. (1983). Lineweaver-Burk, Hanes, Eadie-Hofstee and Dixon Plots in Non-steady-state Situations. Journal of Theoretical Biology, 101, 387-400. doi:10.1016/0022-5193(83)90146-7
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Charlier, P., Coyette, J., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). Instrinct Resistance to beta-lactam antibiotics at the level of the enzyme sites. Many challenges, some achievements. In B. Wiedemann, J.-M. Guysen, K. H. Spitzy, K. Karrer, S. Brayer, R. Lenzhofer, K. Moser, H. Pichler, ... H. Rainer (Eds.), Symposium Mechanisms of resistance to beta-lactam antibiotics : Proceedings.
Peer reviewed

Kelly, J. A., Moews, P. C., Knox, J. R., Frère, J.-M., & Ghuysen, J.-M. (29 October 1982). Penicillin target enzyme and the antibiotic binding site. Science, 218 (4571), 479-481. doi:10.1126/science.7123246
Peer Reviewed verified by ORBi

Frère, J.-M., Kelly, J. A., Klein, D., Ghuysen, J.-M., Claes, P., & Vanderhaeghe, H. (01 April 1982). Δ2- and Δ3-Cephalosporins, penicillinate, and 6-unsubstituted penems. Intrinsic reactivity and interaction with β-lactamases and D-alanyl-D-alanine-cleaving serine peptidases. Biochemical Journal, 203 (1), 223-234. doi:10.1042/bj2030223
Peer Reviewed verified by ORBi

Duez, C., Frère, J.-M., Ghuysen, J.-M., Van Beeumen, J., Delcambe, L., & Dierickx, L. (1982). Purification and properties of the exocellular β-lactamase of Actinomadura strain R39. Biochimica et Biophysica Acta - General Subjects, 700, 24-32. doi:10.1016/0167-4838(82)90287-4
Peer Reviewed verified by ORBi

Dideberg, O., Charlier, P., Dive, G., Joris, B., Frère, J.-M., & Ghuysen, J.-M. (1982). Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution. Nature, 299 (5882), 469-470. doi:10.1038/299469a0
Peer Reviewed verified by ORBi

De Coen, J.-L., Lamotte, J., Ghuysen, J.-M., Frère, J.-M., & Perkins, H. R. (01 December 1981). Conformational analysis of peptide substrates and inhibitors of the Zn2+ G and serine R61 D-alanyl-D-alanine peptidases. European Journal of Biochemistry, 121 (1), 221-232. doi:10.1111/j.1432-1033.1981.tb06452.x
Peer Reviewed verified by ORBi

Perkins, H. R., Frère, J.-M., & Ghuysen, J.-M. (01 December 1981). Synthetic peptide inhibitors of transpeptidation by the exocellular DD-carboxypeptidase-transpeptidase from Actinomadura R39. FEBS Letters, 123 (1), 75-78. doi:10.1016/0014-5793(81)80023-3
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Kelly, J. A., Frère, J.-M., Klein, D., & Ghuysen, J.-M. (01 October 1981). Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases. Biochemical Journal, 199 (1), 129-136. doi:10.1042/bj1990129
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Ley-Bouille, M., & Dideberg, O. (1981). The d-alanyl-d-Ala peptidases. Mechanism of action of penicillins and delta-3-cephalosporins. In M. Salton & G. D. Shockman (Eds.), Beta-Lactam Antibiotics: Mode of Action, New Development, and Future Prospects (pp. 127-152). New York, United States - New York: Academic Press.

Duez, C., Frère, J.-M., Ghuysen, J.-M., Van Beeumen, J., & Vandekerckhove, J. (1981). Studies on the primary structures of the exocellular D-Alanyl-D-Alanine peptidases of Streptomyces strain R61 and Actinomadura strain R39. Biochimica et Biophysica Acta - General Subjects, 671, 109-116. doi:10.1016/0005-2795(81)90123-9
Peer Reviewed verified by ORBi

Kelly, J., Frère, J.-M., Duez, C., & Ghuysen, J.-M. (1981). Interactions between non-classical β-lactam compounds and the β-lactamases of Actinomadura R39 and Streptomyces albus G. Biochemical Journal, 199, 137-143. doi:10.1042/bj1990137
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Delsarte, A., Faway, M., Frère, J.-M., Coyette, J., Calberg-Bacq, C.-M., & Heinen, E. (1981). Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells. Antimicrobial Agents and Chemotherapy, 19 (3), 477-86. doi:10.1128/AAC.19.3.477
Peer Reviewed verified by ORBi

Duez, C., Frère, J.-M., Klein, D., Noël, M., Ghuysen, J.-M., Delcambe, L., & Dierickx, L. (1981). The exocellular β-lactamase of Streptomyces albus G. Purification, properties and comparison with the exocellular DD-carboxypeptidase. Biochemical Journal, 193 (1), 75-82. doi:10.1042/bj1930075
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., & Dideberg, O. (1981). Mode of action of penicillins and Δ3-cephalosporins. On the active centers of serine and zinc(2+) D-alanyl-D-Ala peptidases. In R. N. Ondarza & T. P. Singer (Eds.), Molecular basis of drug action: proceedings of the International Symposium on Molecular Basis of Drug Action, held in Querétaro, Mexico, October 13-16, 1980 (pp. 3-30). Elsevier.
Peer reviewed

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Dideberg, O., Lamotte-Brasseur, J., Perkins, H. R., & De Coen, J.-L. (1981). Penicillins and Δ3-cephalosporins as inhibitors and mechanism-based inactivators of D-alanyl-D-Ala peptidases. In A. S. V. Burgen & G. C. K. Roberts (Eds.), Topics in molecular pharmacology (pp. 64-96). Elsevier.
Peer reviewed

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Coyette, J., Duez, C., Joris, B., Dusart, J., Nguyen-Distèche, M., DideberG, O., Charlier, P., Knox, J. R., Kelly, J. A., Moews, P. C., & DeLucia, M. L. (1981). Mechanistic properties and functioning of DD-carboxypeptidase. In S. Mitsuhashi (Ed.), β-Lactam Antbiotics (pp. 185-202). Tokyo, Japan: Japan Scientific Society Press, Springer.

Duez, C., Joris, B., Frère, J.-M., Ghuysen, J.-M., & Van Beeumen, J. (1981). The penicillin-binding site in the exocellular DD-carboxypeptidase-transpeptidase of Actinomadura R39. Biochemical Journal, 193, 83-86. doi:10.1042/bj1930083
Peer Reviewed verified by ORBi

Frère, J.-M., Klein, D., & Ghuysen, J.-M. (01 October 1980). Enzymatic method for rapid and sensitive determination of β-lactam antibiotics. Antimicrobial Agents and Chemotherapy, 18 (4), 506-510. doi:10.1128/AAC.18.4.506
Peer Reviewed verified by ORBi

Dideberg, O., Joris, B., Frère, J.-M., Ghuysen, J.-M., Weber, G., Robaye, R., Delbrouck, J. M., & Roelandts, I. (11 August 1980). The exocellular DD-carboxypeptidase of Streptomyces albus G: A metallo (Zn2+) enzyme. FEBS Letters, 117 (1-2), 215-218. doi:10.1016/0014-5793(80)80948-3
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Perkins, H.-R., & Nieto, M. (16 May 1980). The active centres in penicillin-sensitive enzymes. Philosophical Transactions. Biological Sciences, 289 (1036), 285-301. doi:10.1098/rstb.1980.0046
Peer Reviewed verified by ORBi

Dideberg, O., Charlier, P., Dupont, L., Vermeire, M., Frère, J.-M., & Ghuysen, J.-M. (1980). The 4.5 Å resolution structure analysis of the exocellular DD-carboxypeptidase of Streptomyces albus G. FEBS Letters, 117 (1), 212-214. doi:10.1016/0014-5793(80)80947-1
Peer Reviewed verified by ORBi

Charlier, P., Coyette, J., Dideberg, O., Duez, C., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Leyh-Bouille, M., & Nguyen-Distèche, M. (1980). On the Active Centers of Serine and Zn II DD-carboxyppetidases. In G. I. Gregory (Ed.), Recent advances in the Chemistry of beta-lactam antibiotics (pp. 184-202). London, United Kingdom: The Royal Society of Chemistry.

Frère, J.-M., Duez, C., Dusart, J., Coyette, J., Leyh-Bouille, M., Ghuysen, J.-M., Dideberg, O., & Knox, J. (1980). Mode of action of B-lactam antibiotics at the molecular level. In M. Sandler, Enzyme inhibitors as drugs (pp. 183-207). Macmillan.
Peer reviewed

Dideberg, O., Frère, J.-M., & Ghuysen, J.-M. (25 April 1979). Crystallographic data for the DD-carboxypeptidase-endopeptidase of low penicillin sensitivity excreted by Streptomyces albus g. Journal of Molecular Biology, 129 (4), 677-679. doi:10.1016/0022-2836(79)90477-7
Peer Reviewed verified by ORBi

Marquet, A., Frère, J.-M., Ghuysen, J.-M., & Loffet, A. (01 March 1979). Effects of nucleophiles on the breakdown of the benzylpenicilloyl-enzyme complex EI formed between benzylpenicillin and the exocellular DD-carboxypeptidase--transpeptiase of Streptomyces strain R61. Biochemical Journal, 177 (3), 909-916. doi:10.1042/bj1770909
Peer Reviewed verified by ORBi

Degelaen, J., Feeney, J., Roberts, G. C. K., Burgen, A. S. V., Frère, J.-M., & Ghuysen, J.-M. (01 February 1979). NMR evidence for the structure of the complex between penicillin and the DD-carboxypeptidase of streptomyces R61. FEBS Letters, 98 (1), 53-56. doi:10.1016/0014-5793(79)80150-7
Peer Reviewed verified by ORBi

Knox, J. R., DeLucia, M. L., Murthy, N. S., Kelly, J. A., Moews, P. C., Frère, J.-M., & Ghuysen, J.-M. (15 January 1979). Crystallographic data for a penicillin receptor : exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 [letter to the editor]. Journal of Molecular Biology, 127 (2), 217-218. doi:10.1016/0022-2836(79)90241-9
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Coyette, J., Dusart, J., & Nguyen-Distèche, M. (01 January 1979). Use of model enzymes in the determination of the mode of action of penicillins and ∆3-cephalosporins. Annual Review of Biochemistry, 48, 73-101. doi:10.1146/annurev.bi.48.070179.000445
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Coyette, J., Dusart, J., Nguyen-Distèche, M., Marquet, A., & Duez, C. (1979). Interaction between penicillin and its enzyme target. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 2, 287-300.
Peer Reviewed verified by ORBi

Adriaens, P., Meesschaert, B., Frère, J.-M., Vanderhaeghe, H., Degelaen, J., Ghuysen, J.-M., & Eyssen, H. (25 April 1978). Stability of D-5,5-dimethyl-delta2-thiazoline-4-carboxylic acid in relation to its possible occurrence as a degradation product of penicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and the membrane-bound dd-carboxypeptidase from Bacillus stearothermophilus. Journal of Biological Chemistry, 253 (10), 3660-3665.
Peer Reviewed verified by ORBi

Schilf, W., Frere, P., Frère, J.-M., Martin, H.-H., Ghuysen, J.-M., Adriaens, P., & Meesschaert, B. (17 April 1978). Interaction between penicillin and the DD-carboxypeptidase of the unstable L-form of Proteus mirabilis strain 19. European Journal of Biochemistry, 85 (2), 325-330. doi:10.1111/j.1432-1033.1978.tb12242.x
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., & De Graeve, J. (01 April 1978). Fragmentation of penicillin catalysed by the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces strain r61. Isotopic study of hydrogen fixation on carbon 6. FEBS Letters, 88 (1), 147-150. doi:10.1016/0014-5793(78)80628-0
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Fossati, P., Saint-Ghislain, M., Sicard, P. J., Frère, J.-M., Dusart, J., Klein, D., & Ghuysen, J.-M. (April 1978). Large Scale Preparation of Purified Exocellular DD-carboxypeptidase-Transpeptidase of Streptomyces Strain R61. Biotechnology and Bioengineering, 20, 577-587. doi:10.1002/bit.260200409
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Duez, C., Frère, J.-M., Geurts, F., Ghuysen, J.-M., Dierickx, L., & Delcambe, L. (1978). The exocellular DD-carboxypeptidase-endopeptidase from Streptomyces albus Gl. Purification and chemical properties. Biochemical Journal, 175 (3), 793-800.
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Frère, J.-M., Geurts, F., & Ghuysen, J.-M. (1978). The exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G. Interaction with beta-lactam antibiotics. Biochemical Journal, 175 (3), 801-805. doi:10.1042/bj1750801
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Nguyen-Distèche, M., Frère, J.-M., Dusart, J., Leyh-Bouille, M., Ghuysen, J.-M., Pollock, J. J., & Iacono, V. J. (15 November 1977). The peptidoglycan crosslinking enzyme system in Streptomyces R61, K15 and rimosus. Immunological studies. European Journal of Biochemistry, 81 (1), 29-32. doi:10.1111/j.1432-1033.1977.tb11923.x
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Frère, J.-M., Duez, C., Ghuysen, J.-M., & Vandekerkhove, J. (November 1976). Occurrence of a serine residue in the penicillin-binding site of the exocellular DD-carboxy-peptidase-transpeptidase from streptomyces R61. FEBS Letters, 70 (1), 257-260. doi:10.1016/0014-5793(76)80770-3
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Frère, J.-M., Ghuysen, J.-M., Vanderhaeghe, H., Adriaens, P., Degelaen, J., & De Graeve, J. (01 April 1976). Fate of thiazolidine ring during fragmentation of penicillin by exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. Nature, 260 (5550), 451-454. doi:10.1038/260451a0
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Frère, J.-M., Ghuysen, J.-M., Zeiger, A., & Perkins, H. R. (15 March 1976). The direction of peptide trimer synthesis from the donor-acceptor substrate Nalpha-(acetyl)-Nepsilon-(glycyl)-L-lysyl-D-alanyl-D-alanine by the exocellular dd-carboxypeptidase-transpeptidase of Streptomyces R61. FEBS Letters, 63 (1), 112-116.
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Frère, J.-M., Leyh-Bouille, M., Ghuysen, J.-M., Nieto, M., & Perkins, H. R. (1976). [51] Exocellular dd-carboxypeptidases-transpeptidases from Streptomyces. In L. Lorand (Ed.), Part B: Proteolytic Enzymes (pp. 610-636). Academic Press. doi:10.1016/S0076-6879(76)45054-1
Peer reviewed

Frère, J.-M., Leyh-Bouille, M., Dusart, J., Coyette, J., & Ghuysen, J.-M. (1976). Penicillin-transpeptidase interaction. In A. Loffett, J. Christophe, ... M. Svoboda, Peptides 1976: proceedings of the Fourteenth European Peptide Symposium, Wepion, Belgium, April 11-17, 1976 (pp. 385-399). Bruxelles, Belgium: Editions Universelles.
Peer reviewed

Fuad, N., Frère, J.-M., Ghuysen, J.-M., Duez, C., & Iwatsubo, M. (1976). Mode of interaction between β-lactam antibiotics and the exocellular DD-carboxypeptidase--transpeptidase from Streptomyces R39. Biochemical Journal, 155 (3), 623-629. doi:10.1042/bj1550623
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Frère, J.-M., Adriaens, P., Degelaen, J., Vanderhaeghe, H., & Ghuysen, J.-M. (01 December 1975). Degradation of benzylpenicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R 61. Archives Internationales de Physiologie et de Biochimie, 83 (5), 905-907. doi:10.3109/13813457509069522
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Frère, J.-M., Ghuysen, J.-M., Degelaen, J., Loffet, A., & Perkins, H. R. (13 November 1975). Fragmentation of benzylpenicillin after interaction with the exocellular DD-carboxypeptidase-transpeptidases of Streptomyces R61 and R39. Nature, 258 (5531), 168-170. doi:10.1038/258168a0
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Frère, J.-M., Ghuysen, J.-M., & Perkins, H. R. (15 September 1975). Interaction between the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61, substrate and beta-lactam antibiotics. A choice of models. European Journal of Biochemistry, 57 (2), 353-359. doi:10.1111/j.1432-1033.1975.tb02308.x
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Frère, J.-M., Ghuysen, J.-M., & Iwatsubo, M. (15 September 1975). Kinetics of interaction between the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and beta-lactam antibiotics. A choice of models. European Journal of Biochemistry, 57 (2), 343-351. doi:10.1111/j.1432-1033.1975.tb02307.x
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Zeiger, A. R., Frère, J.-M., Ghuysen, J.-M., & Perkins, H. R. (01 April 1975). A donor-acceptor substrate of the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61. FEBS Letters, 52 (2), 221-225. doi:10.1016/0014-5793(75)80810-6
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Dusart, J., Nguyen-Distèche, M., Coyette, J., Perkins, H., Nieto, M., & Marquet, A. (1975). Bacterial transpeptidases and penicillin. Bulletin de l'Institut Pasteur, 73 (1), 101-140.
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Johnson, K., Duez, C., Frère, J.-M., & Ghuysen, J.-M. (1975). Beta-lactamases (Actinomycetes species). Methods in Enzymology, XLIII, 687-698. doi:10.1016/0076-6879(75)43134-2
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Frère, J.-M., Leyh-Bouille, M., Ghuysen, J.-M., & Perkins, H. R. (16 December 1974). Interaction between beta-lactam antibiotics and exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. European Journal of Biochemistry, 50 (1), 203-214. doi:10.1111/j.1432-1033.1974.tb03889.x
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Frère, J.-M., Moreno, R., & Ghuysen, J.-M. (01 October 1974). Molecular weight, amino acid composition and physicochemical properties of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39. Biochemical Journal, 143 (1), 233-240. doi:10.1042/bj1430233
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Ghuysen, J.-M., Perkins, H., Frère, J.-M., & Nieto, M. (1974). Antibiotic action on enzymes involved in peptidoglycan synthesis. In H. Sund, Protein-ligand interactions : proceedings of a symposium held at the University of Konstanz (pp. 372-384). Konstanz, Germany: De Gruyter.
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Ghuysen, J.-M., Reynolds, P. E., Perkins, H. R., Frère, J.-M., & Moreno, R. (04 June 1974). Effects of donor and acceptor peptides on concomitant hydrolysis and transfer reactions catalyzed by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R39. Biochemistry, 13 (12), 2539-2547. doi:10.1021/bi00709a010
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Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Marquet, A., Perkins, H. R., & Nieto, M. (10 May 1974). The penicillin receptor in Streptomyces. Annals of the New York Academy of Sciences, 235, 236-268. doi:10.1111/j.1749-6632.1974.tb43269.x
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Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Coyette, J., Nguyen-Distèche, M., & Duez, C. (1974). Comment la Pénicilline tue les bactéries. Annales de Microbiologie, 125 B (2), 209-210.
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Frère, J.-M., Ghuysen, J.-M., Reynolds, P. E., & Moreno, R. (1974). Binding of beta-lactam antibiotics to the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39. Biochemical Journal, 143 (1), 241-249. doi:10.1042/bj1430241
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Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Marquet, A., Perkins, H. R., & Nieto, M. (1974). The penicillin Target in Bacteria. In B. Spencer (Ed.), Industrial Aspects of Biochemistry (FEBS Proceedings) (pp. 579-605). Elsevier. doi:10.1002/food.19750190412
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Nieto, M., Perkins, H. R., Frère, J.-M., & Ghuysen, J.-M. (01 November 1973). Fluorescence and circular dichroism studies on the Streptomyces R61 DD-carboxypeptidase-transpeptidase. Penicillin binding by the enzyme. Biochemical Journal, 135 (3), 493-505. doi:10.1042/bj1350493
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Frère, J.-M., Ghuysen, J.-M., Perkins, H. R., & Nieto, M. (01 November 1973). Molecular weight and amino acid composition of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. Biochemical Journal, 135 (3), 463-468. doi:10.1042/bj1350463
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Frère, J.-M., Ghuysen, J.-M., Perkins, H. R., & Nieto, M. (01 November 1973). Kinetics of concomitant transfer and hydrolysis reactions catalysed by the exocellular DD-carboxypeptidase-transpeptidase of streptomyces R61. Biochemical Journal, 135 (3), 483-492. doi:10.1042/bj1350483
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Perkins, H. R., Nieto, M., Frère, J.-M., Leyh-Bouille, M., & Ghuysen, J.-M. (01 April 1973). Streptomyces DD-carboxypeptidases as transpeptidases. The specificity for amino compounds acting as carboxyl acceptors. Biochemical Journal, 131 (4), 707-718. doi:10.1042/bj1310707
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Dusart, J., Marquet, A., Ghuysen, J.-M., Frère, J.-M., Moreno, R., Leyh-Bouille, M., Johnson, K., Lucchi, C., Perkins, H. R., & Nieto, M. (02 February 1973). DD-carboxypeptidase-transpeptidase and killing site of β-lactam antibiotics in Streptomyces strains R39, R61, and K11. Antimicrobial Agents and Chemotherapy, 3 (2), 181-187. doi:10.1128/AAC.3.2.181
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Ghuysen, J.-M., Leyh-Bouille, M., Campbell, J. N., Frère, J.-M., Duez, C., Nieto, M., & Perkins, H. R. (1973). Structure of the wall peptidoglycan of streptomyces R39 and the specificity profile of its exocellular DD-carboxypeptidase-transpeptidase for peptide acceptors. Biochemistry, 12 (7), 1243-1251. doi:10.1021/bi00731a001
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Perkins, H. R., Ghuysen, J.-M., Nieto, M., Leyh-Bouille, M., & Frère, J.-M. (1973). DD-carboxypeptidases/Transpeptidases and Penicillin Action. In 1st International Congress for Bacteriology, Jerusalem, 2-7 September, 1973. Abstracts. Vol I. Symposia.

Nieto, M., Perkins, H. R., Leyh-Bouille, M., Frère, J.-M., & Ghuysen, J.-M. (01 January 1973). Peptide inhibitors of Streptomyces DD-carboxypeptidases. Biochemical Journal, 131 (1), 163-171. doi:10.1042/bj1310163
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Leyh-Bouille, M., Nakel, M., Frère, J.-M., Johnson, K., Ghuysen, J.-M., Nieto, M., & Perkins, H. R. (28 March 1972). Penicillin-sensitive DD-carboxypeptidases from Streptomyces strains R39 and K11. Biochemistry, 11 (7), 1290-1298. doi:10.1021/bi00757a027
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Pollock, J. J., Ghuysen, J.-M., Linder, R., Salton, M. R. J., Perkins, H. R., Nieto, M., Leyh-Bouille, M., Frère, J.-M., & Johnson, K. (01 March 1972). Transpeptidase activity of Streptomyces D-alanyl-D carboxypeptidases. Proceedings of the National Academy of Sciences of the United States of America, 69 (3), 662-666. doi:10.1073/pnas.69.3.662
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Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Johnson, K., Nakel, M., Coyette, J., Perkins, H., & Nieto, M. (1972). Streptomyces DD carboxypeptidases-transpeptidases and mechanism of action of penicillin. In E. Munoz, Molecular mechanisms of antibiotic action on protein biosynthesis and membranes (pp. 406-426). Elsevier.
Peer reviewed

Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Perkins, H. R., & Nieto, M. (1972). The Streptomyces DD-carboxypeptidase-transpeptidase system as a model for the study of penicillin action. In P. Pratesi (Ed.), Medicinal Chemistry : Special contributions - Milan 1972 (pp. 1-11). London, United Kingdom: Butterworths.

Ghuysen, J.-M., Leyh-Bouille, M., Nakel, M., Dusart, J., Johnson, K., & Frère, J.-M. (1971). DD-carboxypeptidases and Mechanism of Action of Penicillin. In E. Muñoz, F. García-Ferrandiz, ... D. Vazquez (Eds.), Molecular mechanisms of antibiotic action on protein biosynthesis and membranes. Proceedings of a symposium held at the University of Granada (Spain) June 1st-4th (pp. 51-51). Elsevier.

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