![]() ![]() | Verlaine, O.* , Malempré, R.* , Versées, W., Matagne, A., & Frère, J.-M. (05 October 2024). Single time-point analysis of product and substrate inhibition. Scientific Reports, 14 (1). doi:10.1038/s41598-024-70805-9 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Frère, J.-M., Verlaine, O., & Matagne, A. (12 September 2023). The measurement of true initial rates is not always absolutely necessary to estimate enzyme kinetic parameters. Scientific Reports, 13 (1), 15053. doi:10.1038/s41598-023-41805-y ![]() |
![]() ![]() | Radwanska, M., De Lemos Esteves, F., Linsen, L., Coltel, N., Cencig, S., Widart, J., Massart, A.-C., Colson, S., Di Paolo, A., Percier, P., Ait Djebbara, S., Guillonneau, F., Flamand, V., De Pauw, E., Frère, J.-M., Carlier, Y., & Truyens, C. (23 March 2023). Macrophage-infectivity potentiator of Trypanosoma cruzi (TcMIP) is a new pro-type 1 immuno-stimulating protein for neonatal human cells and vaccines in mice. Frontiers in Immunology, 14, 1138526. doi:10.3389/fimmu.2023.1138526 ![]() |
![]() ![]() | Lupo, V., Mercuri, P., Frère, J.-M., Joris, B., Galleni, M., Baurain, D.* , & Kerff, F.*. (2022). An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains. Microbiology Spectrum, 10 (2), 0031522. doi:10.1128/spectrum.00315-22 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Terrak, M., & Frère, J.-M. (2021). β‐Lactam Antibiotics. In S. Offermanns & W. Rosenthal (Eds.), Encyclopedia of Molecular Pharmacology (3rd ed. Encyclopedia of Molecular Pharmacology). Springer, Cham. doi:10.1007/978-3-030-21573-6_29-1 ![]() |
![]() ![]() | Guillerm, J., Frère, J.-M., Meersman, F., & Matagne, A. (2021). The Right-Handed Parallel β-Helix Topology of Erwinia chrysanthemi Pectin Methylesterase Is Intimately Associated with Both Sequential Folding and Resistance to High Pressure. Biomolecules, 11 (8), 1083. doi:10.3390/biom11081083 ![]() |
![]() ![]() | Gavara, L., Sevaille, L., De Luca, F., Mercuri, P., Bebrone, C., Feller, G., Legru, A., Cerboni, G., Tanfoni, S., Baud, D., Cutolo, G., Bestgen, B., Chelini, G., Verdirosa, F., Sannio, F., Pozzi, C., Benvenuti, M., Kwapien, K., Fischer, M., ... Hernandez, J.-F. (2020). 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. European Journal of Medicinal Chemistry, 208, 112720. doi:10.1016/j.ejmech.2020.112720 ![]() |
![]() ![]() | Mack, A. R., Barnes, M. D., Taracila, M. A., Hujer, A. M., Hujer, K. M., Cabot, G., Feldgarden, M., Haft, D. H., Klimke, W., Van Den Akker, F., Vila, A. J., Smania, A., Haider, S., Papp-Wallace, K. M., Bradford, P. A., Rossolini, G. M., Docquier, J.-D., Frère, J.-M., Galleni, M., ... Bonomo, R. A. (2020). A standard numbering scheme for class C β-lactamases. Antimicrobial Agents and Chemotherapy, 64 (3). doi:10.1128/AAC.01841-19 ![]() |
![]() ![]() | Frère, J.-M., Bogaerts, P., Huang, T.-D., Stefanic, P., Moray, J., Bouillenne, F., & Brans, A. (2020). Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases. Biomolecules, 10 (3). doi:10.3390/biom10030483 ![]() |
![]() ![]() | Frère, J.-M., & Verlaine, O. (2020). First-order Kinetics in the Study of Enzymes: Applications to the Reporter Substrate Method and to the Estimation of kcat/Km. Current Biotechnology. ![]() |
Amisano, F., Mercuri, P., Frère, J.-M., & Galleni, M. (20 June 2019). ß-Lactams Translocation through Pseudomonas aeruginosa Outer Membrane [Poster presentation]. ASM Microbe 2019, San Francisco, United States - California. |
![]() ![]() | Renders, M., Dumbre, S., Abramov, M., Kestemont, D., Margamuljana, L., Largy, E., Cozens, C., Vandenameele, J., Pinheiro, V. B., Toye, D., Frère, J.-M., & Herdewijn, P. (2019). Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases. Nucleic Acids Research, 47 (5), 2160-2168. doi:10.1093/nar/gkz008 ![]() |
![]() ![]() | Renders, M., Frère, J.-M., Toye, D., & Herdewijn, P. (2019). Full Pre-Steady-State Kinetic Analysis of Single Nucleotide Incorporation by DNA Polymerases. Current Protocols in Nucleic Acid Chemistry, 78 (1), 98. doi:10.1002/cpnc.98 ![]() |
![]() ![]() | Amisano, F., Silvestri, M., Mercuri, P., Gagliardi, A., Bini, L., Frère, J.-M., & Galleni, M. (17 June 2017). Study of the outer membrane permeability of Pseudomonas aeruginosa to ß-lactam antibiotics [Poster presentation]. 13th Beta lactamase meeting, Santo Stefano di Sessanio, Italy. |
![]() ![]() | Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., ... Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186 ![]() |
![]() ![]() | Abboud, M., Damblon, C., Brem, J., Smargiasso, N., Mercuri, P., Gilbert, B., Rydzik, A., Claridge, T., Schofield, C., & Frère, J.-M. (September 2016). Interaction of Avibactam with Class B Metallo-β-Lactamases. Antimicrobial Agents and Chemotherapy, 60, 5655-6. doi:10.1128/AAC.00897-16 ![]() |
![]() ![]() | Lefurgy, S. T., Malashkevich, V. N., Aguilan, J. T., Nieves, E., Mundorff, E. C., Biju, B., Noel, M. A., Toro, R., Baiwir, D., Papp-Wallace, K. M., Almo, S. C., Frère, J.-M., Bou, G., & Bonomo, R. A. (February 2016). Analysis of the Structure and Function of FOX-4 Cephamycinase. Antimicrobial Agents and Chemotherapy, 60 (2), 717-728. doi:10.1128/AAC.01887-15 ![]() |
![]() ![]() | Fernea, A., Galleni, M., & Frère, J.-M. (2016). Kinetics of the Interaction between BAL29880 and LK157 and the Class C β-Lactamase CHE-1. Antimicrobial Agents and Chemotherapy, 60, 1747-1750. doi:10.1128/AAC.02062-15 ![]() |
![]() ![]() | Frère, J.-M., Sauvage, E., & Kerff, F. (2016). From "an enzyme able to destroy penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour. Current Drug Targets. doi:10.2174/1389450116666151001112859 ![]() |
![]() ![]() | Baurain, D., Wilmotte, A., & Frère, J.-M. (2016). Gram-Negative Bacteria: "Inner" vs. "Cytoplasmic" or "Plasma Membrane": A Question of Clarity rather than Vocabulary. Journal of Microbial and Biochemical Technology, 8 (4), 325-326. doi:10.4172/1948-5948.1000305 |
![]() ![]() | Jourdan, S.* , Francis, I.* , Kim, M., Salazar, J., Planckaert, S., Frère, J.-M., Matagne, A., Kerff, F., Devreese, B., Loria, R., & Rigali, S. (2016). The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity. Scientific Reports. doi:10.1038/srep27144 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Frère, J.-M., & Rigali, S. (2016). The alarming increase in antibiotic-resistant bacteria. Drug Target Review. |
![]() ![]() | Fernea, A., Galleni, M., & Frère, J.-M. (2015). Kinetics of the interaction between avibactam and the CHE-1 class C beta-lactamase. Journal of Antimicrobial Chemotherapy, 70 (3), 951-953. doi:10.1093/jac/dku442 ![]() |
![]() ![]() | Kerff, F., El Ghachi, M., Herman, R., Sauvage, E., Frère, J.-M., & Charlier, P. (06 September 2014). Structures of the Carbapenemase OXA-24 in Complex with the β-lactamase Inhibitor Avibactam [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia. |
![]() ![]() | Frère, J.-M., & Page, M. G. P. (2014). Penicillin-binding proteins: evergreen drug targets. Current Opinion in Pharmacology, 18, 112-9. doi:10.1016/j.coph.2014.09.012 ![]() |
![]() ![]() | Sauvage, E., & Frère, J.-M. (2013). Actinomadura R39 d-Ala-d-Ala Carboxypeptidase. In Handbook of Proteolytic Enzymes (pp. 3480-3484). Elsevier. doi:10.1016/B978-0-12-382219-2.00771-7 ![]() |
![]() ![]() | Zervosen, A., Zapun, A., & Frère, J.-M. (January 2013). Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline. Antimicrobial Agents and Chemotherapy, 57 (1), 661-663. doi:10.1128/AAC.01593-12 ![]() |
![]() ![]() | Dumez, M.-E., Herman, J., Campisi, V., Bouaziz, A., Rosu, F., Luxen, A., Vandenberghe, I., De Pauw, E., Frère, J.-M., Matagne, A., Chevigne, A., & Galleni, M. (2013). The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction. PLoS ONE, 8 (9), 68014. doi:10.1371/journal.pone.0068014 ![]() |
![]() ![]() | Zervosen, A., Sauvage, E., Frère, J.-M., Charlier, P., & Luxen, A. (2012). Development of new drugs for an old target — the penicillin binding proteins. Molecules, 17 (11), 12478-505. doi:10.3390/molecules171112478 ![]() |
Docquier, J.-D., Rossolini, G. M., Nikaido, H., & Frère, J.-M. (2012). Interplay between beta-lactamase activity, outer membrane and active efflux system. In J.-M. Frère, Beta-Lactamases (pp. 401-418). New York, United States: Nova Science Publishers, Inc. |
![]() ![]() | Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J.-M., Masereel, B., Frederick, R., & Wouters, J. (2012). Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles. European Journal of Medicinal Chemistry, 54, 95-102. doi:10.1016/j.ejmech.2012.04.033 ![]() |
![]() ![]() | Kupper, M., Bauvois, C., Frère, J.-M., Galleni, M., & Bebrone, C. (January 2012). The CphAII protein from Aquifex aeolicus exhibits a metal-dependent phosphodiesterase activity. Extremophiles: Life Under Extreme Conditions, 16(1), 45-55. doi:10.1007/s00792-011-0404-1 ![]() |
![]() ![]() | Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y ![]() |
![]() ![]() | Horsfall, L., Izougarhane, Y., Lassaux, P., Selevsek, N., Liénard, B., Poirel, L., Kupper, M., Hoffmann, K., Frère, J.-M., Galleni, M., & Bebrone, C. (April 2011). Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. FEBS Journal, 278(8), 1252-1263. doi:10.1111/j.1742-4658.2011.08046.x ![]() |
![]() ![]() | Dolusic, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J.-M., Masereel, B., Van den Eynde, B., Wouters, J., & Frederick, R. (2011). Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. European Journal of Medicinal Chemistry, 46 (7), 3058-65. doi:10.1016/j.ejmech.2011.02.049 ![]() |
![]() ![]() | Vandevenne, M., Campisi, V., Freichels, A., Gillard, C., Gaspard, G., Frère, J.-M., Galleni, M., & Filée, P. (2011). Comparative functional analysis of the human macrophage chitotriosidase. Protein Science: A Publication of the Protein Society. doi:10.1002/pro.676 ![]() |
![]() ![]() | Lassaux, P., Traoré, D., Loisel, E., Favier, A., Docquier, J.-D., Sohier, J., Laurent, C., Bebrone, C., Frère, J.-M., Ferrer, J.-L., & Galleni, M. (2011). Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01486-09 ![]() |
![]() ![]() | Dolusic, E., Larrieu, P., Blanc, S., Sapunaric, F., Norberg, B., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J.-M., Masereel, B., Van den Eynde, B., Wouters, J., & Frederick, R. (2011). Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Bioorganic and Medicinal Chemistry, 19 (4), 1550-61. doi:10.1016/j.bmc.2010.12.032 ![]() |
Bebrone, C., Kupper, M. B., Dehareng, D., Frère, J.-M., Hoffmann, K., & Galleni, M. (2011). The CphAII protein from Aquifex aeolicus possesses a metal-dependent phosphodiesterase activity [Poster presentation]. 11th β-lactamase meeting, Leonessa, Italy. ![]() |
![]() ![]() | Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008 ![]() |
![]() ![]() | Vandevenne, M., GASPARD, G., Belgsir, E. M., Ramnath, M., Cenatiempo, Y., Delneuville, D., Dumoulin, M., Frère, J.-M., Matagne, A., Galleni, M., & Filee, P. (2011). Effects of monopropanediamino-beta-cyclodextrin on the denaturation process of the hybrid protein BlaPChBD. Biochimica et Biophysica Acta. doi:10.1016/j.bbapap.2011.05.007 ![]() |
![]() ![]() | Vercheval, L., Di Paolo, A., Borel, F., Ferrer, J.-L., Sauvage, E., Matagne, A., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (25 November 2010). Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys 70. Biochemical Journal, 432 (3), 495-504. doi:10.1042/BJ20101122 ![]() |
![]() ![]() | Weide, T., Saldanha, S. A., Minond, D., Spicer, T., Fotsing, J., Spaargaren, M., Frère, J.-M., Bebrone, C., Sharpless, B., Hodder, P., & Fokin, V. (July 2010). NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β- Lactamase: Synthesis and Structure-Activity Studies. ACS Medicinal Chemistry Letters, 1(4), 150-154. ![]() |
![]() ![]() | Lassaux, P., Hamel, M., Gulea, M., Delbrück, H., Mercuri, P., Horsfall, L., Dehareng, D., Kupper, M., Frère, J.-M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases. Journal of Medicinal Chemistry, 53, 4862–4876. doi:10.1021/jm100213c ![]() |
![]() ![]() | Borgianni, L., Vandenameele, J., Matagne, A., Bini, L., Bonomo, R. A., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2010). Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. Antimicrobial Agents and Chemotherapy, 54 (8), 3197-204. doi:10.1128/AAC.01336-09 ![]() |
![]() ![]() | Kerff, F., Petrella, S., Mercier, F., Sauvage, E., Herman, R., Pennartz, A., Zervosen, A., Luxen, A., Frère, J.-M., Joris, B., & Charlier, P. (2010). Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family. Journal of Molecular Biology, 397, 249-259. doi:10.1016/j.jmb.2009.12.038 ![]() |
![]() ![]() | Phichith, D., Bun, S., Padiolleau-Lefevre, S., Guellier, A., Banh, S., Galleni, M., Frère, J.-M., Thomas, D., Friboulet, A., & Avalle, B. (2010). Novel peptide inhibiting both TEM-1 beta-lactamase and penicillin-binding proteins. FEBS Journal, 277 (23), 4965-72. doi:10.1111/j.1742-4658.2010.07906.x ![]() |
![]() ![]() | Mercier, F., Zervosen, A., Teller, N., Frère, J.-M., Herman, R., Pennartz, A., Joris, B., & Luxen, A. (2010). 1,6-AnhMurNAc derivatives for assay development of amidase AmiD. Bioorganic and Medicinal Chemistry, 18 (21), 7422-31. doi:10.1016/j.bmc.2010.09.010 ![]() |
![]() ![]() | Vandenameele, J., Lejeune, A., Di Paolo, A., Brans, A., Frère, J.-M., Schmid, F. X., & Matagne, A. (2010). Folding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways. Biochemistry, 49 (19), 4264-75. doi:10.1021/bi100369d ![]() |
Zervosen, A., Frère, J.-M., & Zapun, A. (May 2009). Enzymatic Inhibition of Streptococcus pneumoniae PBP2x transpeptidase activity by ceftaroline [Poster presentation]. 19th ECCMID, Helsinki, Finland. |
![]() ![]() | Jacquin, O., Balbeur, D., Damblon, C., Marchot, P., De Pauw, E., Roberts, G. C. K., Frère, J.-M., & Matagne, A. (2009). Positively Cooperative Binding of Zinc Ions to Bacillus cereus 569/H/9 beta-Lactamase II Suggests that the Binuclear Enzyme Is the Only Relevant Form for Catalysis. Journal of Molecular Biology, 392 (5), 1278-1291. doi:10.1016/j.jmb.2009.07.092 ![]() |
![]() ![]() | Bebrone, C., Delbrück, H., Kupper, M., Schlömer, P., Willmann, C., Frère, J.-M., Fisher, R., Galleni, M., & Hoffmann, K. (2009). The structure of the di-zinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the "histidine" site. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00288-09 ![]() |
![]() ![]() | Duez, C., Zervosen, A., Teller, N., Melkonian, R., Banzubazé, E., Bouillenne, F., Luxen, A., & Frère, J.-M. (2009). Characterization of the proteins encoded by the Bacillus subtilis yoxA-dacC operon. FEMS Microbiology Letters, 300, 42-47. doi:10.1111/j.1574-6968.2009.01761.x ![]() |
Bebrone, C., Delbrück, H., Wilmann, C., Galleni, M., Frère, J.-M., & Hoffmann, K. (2009). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc ion binds in the Histidine site [Poster presentation]. “Penicillin-recognizing enzymes: from enzyme kinetics to protein folding” symposium, Liège, Belgium. |
![]() ![]() | Baurin, S., Vercheval, L., Bouillenne, F., Falzone, C., Brans, A., Jacquamet, L., Ferrer, J.-L., Sauvage, E., Dehareng, D., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (2009). Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases. Biochemistry, 48 (47), 11252-63. doi:10.1021/bi901548c ![]() |
![]() ![]() | Zeba, B., De Luca, F., Dubus, A., Delmarcelle, M., Simporé, J., Nacoulma, O. G., Rossolini, G. M., Frère, J.-M., & Docquier, J.-D. (2009). IND-6, a Highly Divergent IND-type Metallo-{beta}-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01607-08 ![]() |
![]() ![]() | Lejeune, A., Pain, R. H., Charlier, P., Frère, J.-M., & Matagne, A. (29 January 2008). Tem-1 Beta-Lactamase Folds in a Nonhierarchical Manner with Transient Non-Native Interactions Involving the C-Terminal Region. Biochemistry, 47 (4), 1186-93. doi:10.1021/bi701927y ![]() |
![]() ![]() | Vandevenne, M., Gaspard, G., Yilmaz, N., Giannotta, F., Frère, J.-M., Galleni, M., & Filée, P. (2008). Rapid and easy development of versatile tools to study protein/ligand interactions. Protein Engineering, Design and Selection. doi:10.1093/protein/gzn021 ![]() |
Bebrone, C., Delbrück, H., Kupper, M. B., Galleni, M., Frère, J.-M., & Hoffmann, K. (2008). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc binds in the Histidine site [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany. ![]() |
![]() ![]() | Lienard, B. M. R., Huting, R., Lassaux, P., Galleni, M., Frère, J.-M., & Schofield, C. J. (2008). Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors. Journal of Medicinal Chemistry, 51 (3), 684-8. doi:10.1021/jm070866g ![]() |
![]() ![]() | Lienard, B. M. R., Garau, G., Horsfall, L., Karsisiotis, A. I., Damblon, C., Lassaux, P., Papamicael, C., Roberts, G. C. K., Galleni, M., Dideberg, O., Frère, J.-M., & Schofield, C. J. (2008). Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Organic and Biomolecular Chemistry, 6 (13), 2282-2294. doi:10.1039/b802311e ![]() |
Hubert, S., Rigali, S., Bebrone, C., Kupper, M. B., Hoffmann, K., Vanhulle, S., & Frère, J.-M. (2008). Analysis of the enzymatic component of ligninolytic system of Pycnoporus sanguineus PS7 [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany. ![]() |
![]() ![]() | Michaux, C., Massant, J., Kerff, F., Frère, J.-M., Docquier, J.-D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J., & Wouters, J. (2008). Crystal structure of a cold-adapted class C beta-lactamase. FEBS Journal, 275 (8), 1687-97. doi:10.1111/j.1742-4658.2008.06324.x ![]() |
![]() ![]() | Stoczko, M., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2008). Functional diversity among metallo-β-lactamases: Characterization of the CAR-1 enzyme of Erwinia carotovora. Antimicrobial Agents and Chemotherapy, 52 (7), 2473-2479. doi:10.1128/AAC.01062-07 ![]() |
![]() ![]() | Ruth, N., Quinting, B., Mainil, J., Hallet, B., Frère, J.-M., Huygen, K., & Galleni, M. (2008). Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a class A beta-lactamase. FEBS Journal, 275, 5151-5160. doi:10.1111/j.1742-4658.2008.06646.x ![]() |
![]() ![]() | Dumez, M.-E., Teller, N., Mercier, F., Tanaka, T., Vandenberghe, I., Vandenbranden, M., Devreese, B., Luxen, A., Frère, J.-M., Matagne, A., Jacquet, A., Galleni, M., & Chevigne, A. (2008). Activation mechanism of recombinant Der p 3 allergen zymogen - Contribution of cysteine protease Der p 1 and effect of propeptide glycosylation. Journal of Biological Chemistry, 283 (45), 30606-30617. doi:10.1074/jbc.M803041200 ![]() |
![]() ![]() | Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375 ![]() |
![]() ![]() | Chevigné, A., Barumandzadeh, R., Groslambert, S., Cloes, B., Dehareng, D., Filée, P., Marx, J.-C., Frère, J.-M., Matagne, A., Jacquet, A., & Galleni, M. (16 November 2007). Relationship between propeptide pH unfolding and inhibitory ability during ProDer p 1 activation mechanism. Journal of Molecular Biology, 374 (1), 170-185. doi:10.1016/j.jmb.2007.08.025 ![]() |
Faure, E., Halusiak, E., Ruth, N., Gabriel, S., Filée, P., Giannotta, F., Frère, J.-M., Galleni, M., Jérôme, C., & Jérôme, R. (31 August 2007). Biosensors based on electrochemically prepared polyanilines and bifunctional hybrid proteins [Poster presentation]. Polymers: Last achievements and prospects, in honour of Professor Jérôme, Liège, Belgium. |
![]() ![]() | Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J. W., Adediran, S. A., Pratt, R. F., Frère, J.-M., & Charlier, P. (10 August 2007). Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Journal of Molecular Biology, 371 (2), 528-539. doi:10.1016/j.jmb.2007.05.071 ![]() |
![]() ![]() | Cornaglia, G., Akova, M., Amicosante, G., Canton, R., Cauda, R., Docquier, J.-D., Edelstein, M., Frère, J.-M., Fuzi, M., Galleni, M., Giamarellou, H., Gniadkowski, M., Koncan, R., Libisch, B., Luzzaro, F., Miriagou, V., Navarro, F., Nordmann, P., Pagani, L., ... Rossolini, G. M. (April 2007). Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. International Journal of Antimicrobial Agents, 29 (4), 380-388. doi:10.1016/j.ijantimicag.2006.10.008 ![]() |
![]() ![]() | Chevigné, A., Yilmaz, N., Gaspard, G., Giannotta, F., François, J.-M., Frère, J.-M., Galleni, M., & Filée, P. (30 March 2007). Use of bifunctional hybrid beta-lactamases for epitope mapping and immunoassay development. Journal of Immunological Methods, 320 (1-2), 81-93. doi:10.1016/j.jim.2006.12.009 ![]() |
![]() ![]() | Lienard, B. M. R., Horsfall, L. E., Galleni, M., Frère, J.-M., & Schofield, C. J. (15 February 2007). Inhibitors of the FEZ-1 metallo-beta-lactamase. Bioorganic and Medicinal Chemistry Letters, 17 (4), 964-968. doi:10.1016/j.bmcl.2006.11.053 ![]() |
![]() ![]() | Ishii, Y., Galleni, M., Ma, L., Frère, J.-M., & Yamaguchi, K. (February 2007). Biochemical characterisation of the CTX-M-14 beta-lactamase. International Journal of Antimicrobial Agents, 29 (2), 159-164. doi:10.1016/j.ijantimicag.2006.09.005 ![]() |
![]() ![]() | Vandevenne, M., Filée, P., Scarafone, N., Cloes, B., Gaspard, G., Yilmaz, N., Dumoulin, M., François, J.-M., Frère, J.-M., & Galleni, M. (2007). The Bacillus licheniformis BlaP beta-lactamase as a model protein scaffold to study the insertion of protein fragments. Protein Science: A Publication of the Protein Society, 16 (10), 2260-71. doi:10.1110/ps.072912407 ![]() |
![]() ![]() | Gangoue Pieboji, J., Baurin, S., Frère, J.-M., Ngassam, P., Ngameni, B., Azebaze, A., Pegnyemb, D. E., Watchueng, J., Goffin, C., & Galleni, M. (2007). Screening of some medicinal plants from cameroon for beta-lactamase inhibitory activity. Phytotherapy Research, 21 (3), 284-7. doi:10.1002/ptr.2001 ![]() |
![]() ![]() | Lassaux, P., Hamel, M., Gulea, M., Mercuri, P., Horsfall, L., Bebrone, C., Gaumont, A.-C., Frère, J.-M., & Galleni, M. (2007). Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. International Journal of Antimicrobial Agents, 29 (Supplément 2), 95. ![]() |
Giannotta, Filée, P., Galleni, M., Frère, J.-M., Joris, B., Brans, A., & Ruth, N. (25 October 2006). Hybrid proteins of active-site serine beta-lactamase. |
![]() ![]() | chouchani, C., Berlemont, R., masmoudi, A., Galleni, M., Frère, J.-M., belhadj, O., & ben-mahrez, K. (September 2006). A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis. Antimicrobial Agents and Chemotherapy, 50 (9), 3183-5. doi:10.1128/AAC.00388-06 ![]() |
![]() ![]() | Fraipont, C., Sapunaric, F., Zervosen, A., Auger, G., Devreese, B., Lioux, T., Blanot, D., Mengin-Lecreulx, D., Herdewijn, P., Van Beeumen, J., Frère, J.-M., & Nguyen-Distèche, M. (28 March 2006). Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: Specificity profile for the substrate. Biochemistry, 45 (12), 4007-4013. doi:10.1021/bi051055m ![]() |
![]() ![]() | Zawadzka-Skomial, J., Markiewicz, Z., Nguyen-Distèche, M., Devreese, B., Frère, J.-M., & Terrak, M. (March 2006). Characterization of the bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 of Listeria monocytogenes. Journal of Bacteriology, 188 (5), 1875-1881. doi:10.1128/JB.188.5.1875-1881.2006 ![]() |
![]() ![]() | De Vriendt, K., Van Driessche, G., Devreese, B., Bebrone, C., Anne, C., Frère, J.-M., Galleni, M., & Van Beeumen, J. (February 2006). Monitoring the zinc affinity of the metallo-beta-lactamase CphA by automated nanoESI-MS. Journal of the American Society for Mass Spectrometry, 17 (2), 180-188. doi:10.1016/j.jasms.2005.10.007 ![]() |
![]() ![]() | Stoczko, M., Frère, J.-M., Rossolini, G. M., & Docquier, J.-D. (2006). Postgenomic scan of metallo-β-lactamase homologues in rhizobacteria: Identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum. Antimicrobial Agents and Chemotherapy, 50 (6), 1973-1981. doi:10.1128/AAC.01551-05 ![]() |
![]() ![]() | Sauvage, E., Fonze, E., Quinting, B., Galleni, M., Frère, J.-M., & Charlier, P. (2006). Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity. Antimicrobial Agents and Chemotherapy, 50 (7), 2516-21. doi:10.1128/AAC.01226-05 ![]() |
Trovaslet, M., Bebrone, C., Enaud, E., Hubert, S., Nouaimeh, N., Pamplona, M., Lorenzini, B., Bols, C.-M., Frère, J.-M., & Corbisier, A.-M. (2006). Kinetic activation of Pycnoporus sanguineus laccase in presence of dyes [Poster presentation]. 3rd European Meeting in Oxizymes, Oeiras, Portugal. ![]() |
![]() ![]() | Rhazi, N., Delmarcelle, M., Sauvage, E., Jacquemotte, F., Devriendt, K., Tallon, V., Ghosez, L., & Frère, J.-M. (November 2005). Specificity and reversibility of the transpeptidation reaction catalyzed by the Streptomyces R61 D-Ala-D-Ala peptidase. Protein Science: A Publication of the Protein Society, 14 (11), 2922-2928. doi:10.1110/ps.051641005 ![]() |
![]() ![]() | Moreira, P. R., Duez, C., Dehareng, D., Antunes, A., Almeida-Vara, E., Frère, J.-M., Malcata, F. X., & Duarte, J. C. (10 September 2005). Molecular characterisation of a versatile peroxidase from a Bjerkandera strain. Journal of Biotechnology, 118 (4), 339-352. doi:10.1016/j.jbiotec.2005.05.014 ![]() |
![]() ![]() | Bebrone, C., Anne, C., De Vriendt, K., Devreese, B., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (05 August 2005). Dramatic broadening of the substrate profile of the Aeromonas hydrophila CphA metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 280 (31), 28195-28202. doi:10.1074/jbc.M414052200 ![]() |
Deleu, M., Brasseur, R., Paquot, M., Legros, H., Dufour, S., Jacques, P., Destain, J., Thonart, P., Brans, A., Joris, B., & Frère, J.-M. (11 May 2005). Novel use of lipopeptide preparations. |
![]() ![]() | Ruth, N., Mainil, J., Roupie, V., Frère, J.-M., Galleni, M., & Huygen, K. (May 2005). DNA vaccination for the priming of neutralizing antibodies against non-immunogenic STa enterotoxin from enterotoxigenic Escherichia coli. Vaccine, 23 (27), 3618-3627. doi:10.1016/j.vaccine.2004.11.080 ![]() |
![]() ![]() | De Lemos Esteves, F., Gouders, T., Lamotte-Brasseur, J., Rigali, S., & Frère, J.-M. (February 2005). Improving the alkalophilic performances of the Xyl1 xylanase from Streptomyces sp S38: Structural comparison and mutational analysis. Protein Science: A Publication of the Protein Society, 14 (2), 292-302. doi:10.1110/ps.04978705 ![]() |
![]() ![]() | Garau, G., Bebrone, C., Anne, C., Galleni, M., Frère, J.-M., & Dideberg, O. (28 January 2005). A metallo-beta-lactamase enzyme in action: Crystal structures of the monozinc carbapenemase CphA and its complex with biapenem. Journal of Molecular Biology, 345 (4), 785-795. doi:10.1016/j.jmb.2004.10.070 ![]() |
![]() ![]() | Sauvage, E., Herman, R., Petrella, S., Duez, C., Bouillenne, F., Frère, J.-M., & Charlier, P. (2005). Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins. Journal of Biological Chemistry, 280 (35), 31249-56. doi:10.1074/jbc.M503271200 ![]() |
![]() ![]() | Bauvois, C., Ibuka, A. S., Celso, A., Alba, J., Ishii, Y., Frère, J.-M., & Galleni, M. (2005). Kinetic properties of four plasmid-mediated AmpC beta-lactamases. Antimicrobial Agents and Chemotherapy, 49 (10), 4240-6. doi:10.1128/AAC.49.10.4240-4246.2005 ![]() |
![]() ![]() | Delmarcelle, M., Boursoit, M.-C., Filée, P., Baurin, S. L., Frère, J.-M., & Joris, B. (2005). Specificity inversion of Ochrobactrum anthropi D-aminopeptidase to a D,D-carboxypeptidase with new penicillin binding activity by directed mutagenesis. Protein Science: A Publication of the Protein Society, 14, 2296-2303. doi:10.1110/ps.051475305 ![]() |
![]() ![]() | Michaux, C., Charlier, P., Frère, J.-M., & Wouters, J. (2005). Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies. Journal of the American Chemical Society, 127 (10), 3262-3. doi:10.1021/ja0426241 ![]() |
![]() ![]() | Llinas, A., Ahmed, N., Cordaro, M., Laws, A. P., Frère, J.-M., Delmarcelle, M., Silvaggi, N. R., Kelly, J. A., & Page, M. I. (2005). Inactivation of bacterial DD-peptidase by beta-sultams. Biochemistry, 44 (21), 7738-46. doi:10.1021/bi050110o ![]() |
![]() ![]() | Frère, J.-M., Galleni, M., Bush, K., & Dideberg, O. (2005). Is it necessary to change the classification of ß-lactamases? Journal of Antimicrobial Chemotherapy, 55 (6), 1051-1053. doi:10.1093/jac/dki155 ![]() |
De Lemos Esteves, F., Ruelle, V., Gouders, T., Lamotte-Brasseur, J., Quinting, B., Rigali, S., & Frère, J.-M. (December 2004). On the way of understanding the adaptation to extreme pH of family 11 xylanases: Structural comparison and mutational analysis [Poster presentation]. Bioforum, Liège, Belgium. |
![]() ![]() | Vreuls, C., Filée, P., Van Melckebeke, H., Aerts, T., De Deyn, P., Llabres, G., Matagne, A., Simorre, J. P., Frère, J.-M., & Joris, B. (15 November 2004). Guanidinium chloride denaturation of the dimeric Bacillus licheniformis Blal repressor highlights an independent domain unfolding pathway. Biochemical Journal, 384 (Pt 1), 179-190. doi:10.1042/BJ20040658 ![]() |
![]() ![]() | Mercuri, P., Garcia-Saez, I., De Vriendt, K., Thamm, I., Devreese, B., Van Beeumen, J., Dideberg, O., Rossolini, G. M., Frère, J.-M., & Galleni, M. (06 August 2004). Probing the specificity of the subclass B3 FEZ-1 metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 279 (32), 33630-33638. doi:10.1074/jbc.M403671200 ![]() |
![]() ![]() | Garau, G., Garcia-Saez, I., Bebrone, C., Anne, C., Mercuri, P., Galleni, M., Frère, J.-M., & Dideberg, O. (July 2004). Update of the standard numbering scheme for class B beta-lactamases. Antimicrobial Agents and Chemotherapy, 48 (7), 2347-2349. doi:10.1128/AAC.48.7.2347-2349.2004 ![]() |
Dreesen, L., Sartenaer, Y., Humbert, C., Caudano, Y., Volcke, C., Mani, A. A., Peremans, A., Thiry, P., Hanique, S., & Frère, J.-M. (June 2004). Two-color-sum-frequency generation characterization of a protein monolayer adsorbed on a metallic substrate [Poster presentation]. 11 th International Conference on Vibrations at Surfaces, Bar Harbor, United States. |
Dreesen, L., Sartenaer, Y., Humbert, C., Caudano, Y., Volcke, C., Mani, A. A., Peremans, A., Thiry, P., Hanique, S., & Frère, J.-M. (25 May 2004). Two-color-sum-frequency generation characterization of a protein monolayer adsorbed on a metallic substrate [Poster presentation]. Belgian Physical Society Meeting, Mons, Belgium. |
![]() ![]() | Tsang, W. Y., Dhanda, A., Schofield, C. J., Frère, J.-M., Galleni, M., & Page, M. I. (05 April 2004). The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. Bioorganic and Medicinal Chemistry Letters, 14 (7), 1737-1739. doi:10.1016/j.bmcl.2004.01.047 ![]() |
![]() ![]() | Hanique, S., Colombo, M.-L., Goormaghtigh, E., Soumillion, P., Frère, J.-M., & Joris, B. (02 April 2004). Evidence of an intramolecular interaction between the two domains of the BlaR1 penicillin receptor during the signal transduction. Journal of Biological Chemistry, 279 (14), 14264-14272. doi:10.1074/jbc.M313488200 ![]() |
![]() ![]() | Zervosen, A., Lu, W.-P., Chen, Z., White, R. E., Demuth, T. P., & Frère, J.-M. (March 2004). Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones. Antimicrobial Agents and Chemotherapy, 48 (3), 961-969. doi:10.1128/AAC.48.3.961-969.2004 ![]() |
![]() ![]() | Colombo, M.-L., Hanique, S., Baurin, S. L., Bauvois, C., De Vriendt, K., Van Beeumen, J. J., Frère, J.-M., & Joris, B. (February 2004). The ybxI gene of Bacillus subtilis 168 encodes a class D beta-lactamase of low activity. Antimicrobial Agents and Chemotherapy, 48 (2), 484-490. doi:10.1128/AAC.48.2.484-490.2004 ![]() |
![]() ![]() | De Lemos Esteves, F., Ruelle, V., Lamotte-Brasseur, J., Quinting, B., & Frère, J.-M. (01 February 2004). Acidophilic adaptation of family 11 endo--1,4-xylanases: Modeling and mutational analysis. Protein Science: A Publication of the Protein Society, 13 (5), 1209–1218. doi:10.1110/ps.03556104 ![]() |
![]() ![]() | Dreesen, L., Humbert, C., Sartenaer, Y., Caudano, Y., Volcke, C., Mani, A. A., Peremans, A., Thiry, P. A., Hanique, S., & Frère, J.-M. (2004). Electronic and Molecular Properties of an Adsorbed Protein Monolayer Probed by Two-Color Sum-Frequency Generation Spectroscopy. Langmuir, 20 (17), 7201-7207. doi:10.1021/la0488001 ![]() |
![]() ![]() | Docquier, J.-D., Lopizzo, T., Liberatori, S., Prenna, M., Thaller, M. C., Frère, J.-M., & Rossolini, G. M. (2004). Biochemical characterization of the THIN-B metallo-β-lactamase of Janthinobacterium lividum. Antimicrobial Agents and Chemotherapy, 48 (12), 4778-4783. doi:10.1128/AAC.48.12.4778-4783.2004 ![]() |
![]() ![]() | Genereux, C., Dehareng, D., Devreese, B., Van Beeumen, J., Frère, J.-M., & Joris, B. (01 January 2004). Mutational analysis of the catalytic centre of the Citrobacter freundii AmpD N-acetylmuramyl-L-alanine amidase. Biochemical Journal, 377 (Pt 1), 111-120. doi:10.1042/BJ20030862 ![]() |
![]() ![]() | Ghuysen, J.-M., & Frère, J.-M. (2004). B-Lactam Antibiotics. In Encyclopedic Reference of Molecular Pharmacology (pp. 679-683). Springer. |
![]() ![]() | Grisart, B., Farnir, F., Karim, L., Cambisano, N., Kim, J.-J., Kvasz, A., Mni, M., Simon, P., Frère, J.-M., Coppieters, W., & Georges, M. (2004). Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proceedings of the National Academy of Sciences of the United States of America, 101 (8), 2398-2403. doi:10.1073/pnas.0308518100 ![]() |
Deleu, M., Brans, A., Brasseur, R., Destain, J., Dufour, S., Frère, J.-M., Jacques, P., Joris, B., Legros, H., Paquot, M., & Thonart, P. (2004). Novel use of lipopeptide preparations. |
![]() ![]() | Kerff, F., Charlier, P., Colombo, M. L., Sauvage, E., Brans, A., Frère, J.-M., Joris, B., & Fonze, E. (11 November 2003). Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis. Biochemistry, 42 (44), 12835-12843. doi:10.1021/bi034976a ![]() |
![]() ![]() | Ibuka, A. S., Ishii, Y., Galleni, M., Ishiguro, M., Yamaguchi, K., Frère, J.-M., Matsuzawa, H., & Sakai, H. (16 September 2003). Crystal structure of extended-spectrum beta-lactamase Toho-1: Insights into the molecular mechanism for catalytic reaction and substrate specificity expansion. Biochemistry, 42 (36), 10634-10643. doi:10.1021/bi0342822 ![]() |
![]() ![]() | Alba, J., Bauvois, C., Ishii, Y., Galleni, M., Masuda, K., Ishiguro, M., Ito, M., Frère, J.-M., & Yamaguchi, K. (29 August 2003). A detailed kinetic study of Mox-1, a plasmid-encoded class C beta-lactamase. FEMS Microbiology Letters, 225 (2), 183-188. doi:10.1016/S0378-1097(03)00448-8 ![]() |
![]() ![]() | Wouters, J., Fonze, E., Vermeire, M., Frère, J.-M., & Charlier, P. (August 2003). Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue. Cellular and Molecular Life Sciences, 60 (8), 1764-1773. doi:10.1007/s00018-003-3189-2 ![]() |
![]() ![]() | Anderson, J. W., Adediran, S. A., Charlier, P., Nguyen-Distèche, M., Frère, J.-M., Nicholas, R. A., & Pratt, R. F. (01 August 2003). On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides. Biochemical Journal, 373 (Part 3), 949-955. doi:10.1042/BJ20030217 ![]() |
![]() ![]() | Garcia-Saez, I., Hopkins, J., Papamicael, C., Franceschini, N., Amicosante, G., Rossolini, G. M., Galleni, M., Frère, J.-M., & Dideberg, O. (27 June 2003). The 1.5-angstrom structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril. Journal of Biological Chemistry, 278 (26), 23868-23873. ![]() |
![]() ![]() | Duval, V., Swinnen, M., Lepage, S., Brans, A., Granier, B., Franssen, C., Frère, J.-M., & Joris, B. (June 2003). The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of beta-lactamase synthesis. Molecular Microbiology, 48 (6), 1553-1564. doi:10.1046/j.1365-2958.2003.03520.x ![]() |
![]() ![]() | Filée, P., Vreuls, C., Herman, R., Thamm, I., Aerts, T., De Deyn, P. P., Frère, J.-M., & Joris, B. (May 2003). Dimerization and DNA binding properties of the Bacillus licheniformis 749/I BlaI repressor. Journal of Biological Chemistry, 278 (19), 16482-16487. doi:10.1074/jbc.M210887200 ![]() |
![]() ![]() | Moali, C., Anne, C., Lamotte-Brasseur, J., Groslambert, S., Devreese, B., Van Beeumen, J., Galleni, M., & Frère, J.-M. (April 2003). Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis. Chemistry and Biology, 10 (4), 319-329. doi:10.1016/S1074-5521(03)00070-X ![]() |
![]() ![]() | Rhazi, N., Charlier, P., Dehareng, D., Engher, D., Vermeire, M., Frère, J.-M., Nguyen-Distèche, M., & Fonze, E. (18 March 2003). Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42 (10), 2895-2906. doi:10.1021/bi027256x ![]() |
![]() ![]() | Docquier, J.-D., Lamotte-Brasseur, J., Galleni, M., Amicosante, G., Frère, J.-M., & Rossolini, G. M. (February 2003). On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy, 51 (2), 257-266. doi:10.1093/jac/dkg067 ![]() |
![]() ![]() | Garcia-Saez, I., Mercuri, P., Papamicael, C., Kahn, R., Frère, J.-M., Galleni, M., Rossolini, G. M., & Dideberg, O. (24 January 2003). Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. Journal of Molecular Biology, 325 (4), 651-660. doi:10.1016/S0022-2836(02)01271-8 ![]() |
![]() ![]() | Vanhove, M., Zakhem, M., Devreese, B., Franceschini, N., Anne, C., Bebrone, C., Amicosante, G., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (2003). Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase. Cellular and Molecular Life Sciences, 60 (11), 2501-9. doi:10.1007/s00018-003-3092-x ![]() |
![]() ![]() | Lakaye, B., Dubus, A., Joris, B., & Frère, J.-M. (September 2002). Method for estimation of low outer membrane permeability to beta-lactam antibiotics. Antimicrobial Agents and Chemotherapy, 46 (9), 2901-2907. doi:10.1128/AAC.46.9.2901-2907.2002 ![]() |
![]() ![]() | Wommer, S., Rival, S., Heinz, U., Galleni, M., Frère, J.-M., Franceschini, N., Amicosante, G., Rasmussen, B., Bauer, R., & Adolph, H. W. (05 July 2002). Substrate-activated zinc binding of metallo-beta-lactamases - Physiological importance of the mononuclear enzymes. Journal of Biological Chemistry, 277 (27), 24142-24147. doi:10.1074/jbc.M202467200 ![]() |
![]() ![]() | Vessillier, S., Docquier, J.-D., Rival, S., Frère, J.-M., Galleni, M., Amicosante, G., Rossolini, G. M., & Franceschini, N. (June 2002). Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase. Antimicrobial Agents and Chemotherapy, 46 (6), 1921-1927. doi:10.1128/AAC.46.6.1921-1927.2002 ![]() |
![]() ![]() | Docquier, J.-D., Pantanella, F., Giuliani, F., Thaller, M. C., Amicosante, G., Galleni, M., Frère, J.-M., Bush, K., & Rossolini, G. M. (June 2002). CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome. Antimicrobial Agents and Chemotherapy, 46 (6), 1823-1830. doi:10.1128/AAC.46.6.1823-1830.2002 ![]() |
![]() ![]() | Filée, P., Benlafya, K., Delmarcelle, M., Moutzourelis, G., Frère, J.-M., Brans, A., & Joris, B. (May 2002). The fate of the Blal repressor during the induction of the Bacillus licheniformis BlaP beta-lactamase. Molecular Microbiology, 44 (3), 685-694. doi:10.1046/j.1365-2958.2002.02888.x ![]() |
![]() ![]() | De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687 ![]() |
![]() ![]() | Fonzé, E., Vanhove, M., Dive, G., Sauvage, E., Frère, J.-M., & Charlier, P. (February 2002). Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin. Biochemistry, 41 (6), 1877-1885. doi:10.1021/bi015789k ![]() |
![]() ![]() | Matagne, A., Galleni, M., Laraki, N., Amicosante, G., Rossolini, G., & Frère, J.-M. (2002). Beta-lactamases, an old but ever renascent problem. In A. van Broekhoven (Ed.), Novel Frontiers in the Production of Compounds for Biomedical Use. Dordrecht, Netherlands: Kluwer Academic Publishers. ![]() |
![]() ![]() | Mercuri, P., Ishii, Y., Ma, L., Rossolini, G. M., Luzzaro, F., Amicosante, G., Franceschini, N., Frère, J.-M., & Galleni, M. (2002). Clonal diversity and metallo-beta-lactamase production in clinical isolates of Stenotrophomonas maltophilia. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 8 (3), 193-200. doi:10.1089/107662902760326904 ![]() |
![]() ![]() | De Seny, D., Heinz, U., Wommer, S., Kiefer, M., Meyer-Klaucke, W., Galleni, M., Frère, J.-M., Bauer, R., & Adolph, H. W. (30 November 2001). Metal Ion Binding and Coordination Geometry for Wild Type and Mutants of Metallo-Beta -Lactamase from Bacillus Cereus 569/H/9 (Bcii): A Combined Thermodynamic, Kinetic, and Spectroscopic Approach. Journal of Biological Chemistry, 276 (48), 45065-78. doi:10.1074/jbc.M106447200 ![]() |
![]() ![]() | Lejeune, A., Vanhove, M., Lamotte-Brasseur, J., Pain, R. H., Frère, J.-M., & Matagne, A. (August 2001). Quantitative Analysis of the Stabilization by Substrate of Staphylococcus Aureus Pc1 Beta-Lactamase. Chemistry and Biology, 8 (8), 831-42. doi:10.1016/S1074-5521(01)00053-9 ![]() |
![]() ![]() | Vilar, M., Galleni, M., Solmajer, T., Turk, B., Frère, J.-M., & Matagne, A. (August 2001). Kinetic Study of Two Novel Enantiomeric Tricyclic Beta-Lactams Which Efficiently Inactivate Class C Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (8), 2215-23. doi:10.1128/AAC.45.8.2215-2223.2001 ![]() |
![]() ![]() | Zervosen, A., Valladares, M. H., Devreese, B., Prosperi, C., Adolph, H.-W., Mercuri, P., Vanhove, M., Amicosante, G., van Beeumen, J., Frère, J.-M., & Galleni, M. (July 2001). Inactivation of Aeromonas Hydrophila Metallo-Beta-Lactamase by Cephamycins and Moxalactam. European Journal of Biochemistry, 268 (13), 3840-50. doi:10.1046/j.1432-1327.2001.02298.x ![]() |
![]() ![]() | Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J.-D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J.-M., & Galleni, M. (June 2001). Centa as a Chromogenic Substrate for Studying Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (6), 1868-71. doi:10.1128/AAC.45.6.1868-1871.2001 ![]() |
![]() ![]() | Mercuri, P., Bouillenne, F., Boschi, L., Lamotte-Brasseur, J., Amicosante, G., Devreese, B., van Beeumen, J., Frère, J.-M., Rossolini, G. M., & Galleni, M. (April 2001). Biochemical Characterization of the Fez-1 Metallo-Beta-Lactamase of Legionella Gormanii Atcc 33297t Produced in Escherichia Coli. Antimicrobial Agents and Chemotherapy, 45 (4), 1254-62. doi:10.1128/AAC.45.4.1254-1262.2001 ![]() |
![]() ![]() | Galleni, M., Lamotte-Brasseur, J., Rossolini, G. M., Spencer, J., Dideberg, O., & Frère, J.-M. (March 2001). Standard Numbering Scheme for Class B Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (3), 660-3. doi:10.1128/AAC.45.3.660-663.2001 ![]() |
Duez, C., Vanhove, M., Gallet, X., Bouillenne, F., Docquier, J.-D., Brans, A., & Frère, J.-M. (March 2001). Purification and Characterization of Pbp4a, a New Low-Molecular-Weight Penicillin-Binding Protein from Bacillus subtilis. Journal of Bacteriology, 183 (5), 1595-9. doi:10.1128/JB.183.5.1595-1599.2001 ![]() |
![]() ![]() | Wouters, J., Charlier, P., Monnaie, D., Frère, J.-M., & Fonze, E. (2001). Expression, purification, crystallization and preliminary X-ray analysis of the native class C beta-lactamase from Enterobacter cloacae 908R and two mutants. Acta Crystallographica. Section D, Biological Crystallography, 57 (Pt 1), 162-4. doi:10.1107/S0907444900016413 ![]() |
Mollard, C., Moali, C., Papamicael, C., Damblon, C., Vessilier, S., Amicosante, G., Schofield, C. J., Galleni, M., Frère, J.-M., & Roberts, G. C. (2001). Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. Journal of Biological Chemistry, 276 (48), 45015-23. doi:10.1074/jbc.M107054200 ![]() |
Bebrone, C., Fastrez, J., Frère, J.-M., & Galleni, M. (2001). Centa as a chromogenic substrate for the study of β-lactamases [Poster presentation]. Bioforum, Liège, Belgium. |
![]() ![]() | Wouters, J., Georis, J., Engher, D., Vandenhaute, J., Dusart, J., Frère, J.-M., Depiereux, E., & Charlier, P. (2001). Crystallographic analysis of family 11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38. Acta Crystallographica. Section D, Biological Crystallography, 57 (Pt 12), 1813-9. doi:10.1107/S0907444901015153 ![]() |
![]() ![]() | Franceschini, N., Boschi, L., Pollini, S., Herman, R., Perilli, M., Galleni, M., Frère, J.-M., Amicosante, G., & Rossolini, G. M. (2001). Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties. Antimicrobial Agents and Chemotherapy, 45 (12), 3509-16. doi:10.1128/AAC.45.12.3509-3516.2001 ![]() |
![]() ![]() | Conrath, K. E., Lauwereys, M., Galleni, M., Matagne, A., Frère, J.-M., Kinne, J., Wyns, L., & Muyldermans, S. (2001). Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. Antimicrobial Agents and Chemotherapy, 45 (10), 2807-12. doi:10.1128/AAC.45.10.2807-2812.2001 ![]() |
![]() ![]() | Cheggour, A., Fanuel, L., Duez, C., Joris, B., Bouillenne, F., Devreese, B., Van Driessche, G., Van Beeumen, J., Frère, J.-M., & Goffin, C. (November 2000). The Dppa Gene of Bacillus Subtilis Encodes a New D-Aminopeptidase. Molecular Microbiology, 38 (3), 504-13. doi:10.1046/j.1365-2958.2000.02117.x ![]() |
Georis, J., De Lemos Esteves, F., Lamotte-Brasseur, J., Bougnet, V., Devreese, B., Giannotta, F., Granier, B., & Frère, J.-M. (March 2000). An Additional Aromatic Interaction Improves the Thermostability and Thermophilicity of a Mesophilic Family 11 Xylanase: Structural Basis and Molecular Study. Protein Science: A Publication of the Protein Society, 9 (3), 466-75. doi:10.1110/ps.9.3.466 ![]() |
Bompard-Gilles, C., Remaut, H., Villeret, V., Prange, T., Fanuel, L., Delmarcelle, M., Joris, B., Frère, J.-M., & Van Beeumen, J. (2000). Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family. Structure, 8 (9), 971-80. doi:10.1016/S0969-2126(00)00188-X ![]() |
![]() ![]() | Bouillenne, F., Matagne, A., Joris, B., & Frère, J.-M. (2000). Technique for a rapid and efficient purification of the SHV-1 and PSE-2 beta-lactamases. Journal of Chromatography. B, Biomedical Sciences and Applications, 737 (1-2), 261-5. doi:10.1016/S0378-4347(99)00436-3 ![]() |
![]() ![]() | Bompard-Gilles, C., Villeret, V., Davies, G. J., Fanuel, L., Joris, B., Frère, J.-M., & Van Beeumen, J. (2000). A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi. Structure, 8 (2), 153-62. doi:10.1016/S0969-2126(00)00091-5 ![]() |
![]() ![]() | Concha, N. O., Janson, C. A., Rowling, P., Pearson, S., Cheever, C. A., Clarke, B. P., Lewis, C., Galleni, M., Frère, J.-M., Payne, D. J., Bateson, J. H., & Abdel-Meguid, S. S. (2000). Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor. Biochemistry, 39 (15), 4288-98. doi:10.1021/bi992569m ![]() |
![]() ![]() | Hernandez Valladares, M., Kiefer, M., Heinz, U., Soto, R. P., Meyer-Klaucke, W., Nolting, H. F., Zeppezauer, M., Galleni, M., Frère, J.-M., Rossolini, G. M., Amicosante, G., & Adolph, H. W. (2000). Kinetic and spectroscopic characterization of native and metal-substituted beta-lactamase from Aeromonas hydrophila AE036. FEBS Letters, 467 (2-3), 221-5. doi:10.1016/S0014-5793(00)01102-9 ![]() |
![]() ![]() | Boschi, L., Mercuri, P., Riccio, M. L., Amicosante, G., Galleni, M., Frère, J.-M., & Rossolini, G. M. (2000). The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases. Antimicrobial Agents and Chemotherapy, 44 (6), 1538-43. doi:10.1128/AAC.44.6.1538-1543.2000 ![]() |
![]() ![]() | Chantalat, L., Duee, E., Galleni, M., Frère, J.-M., & Dideberg, O. (2000). Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase. Protein Science: A Publication of the Protein Society, 9 (7), 1402-6. doi:10.1110/ps.9.7.1402 ![]() |
![]() ![]() | Franceschini, N., Caravelli, B., Docquier, J.-D., Galleni, M., Frère, J.-M., Amicosante, G., & Rossolini, G. M. (2000). Purification and biochemical characterization of the VIM-1 metallo-beta-lactamase. Antimicrobial Agents and Chemotherapy, 44 (11), 3003-7. doi:10.1128/AAC.44.11.3003-3007.2000 ![]() |
![]() ![]() | Rhazi, N., Galleni, M., Page, M. I., & Frère, J.-M. (15 July 1999). Peptidase Activity of Beta-Lactamases. Biochemical Journal, 341 ((Pt 2)), 409-13. doi:10.1042/0264-6021:3410409 ![]() |
![]() ![]() | Laraki, N., Galleni, M., Thamm, I., Riccio, M. L., Amicosante, G., Frère, J.-M., & Rossolini, G. M. (April 1999). Structure of In31, a Blaimp-Containing Pseudomonas Aeruginosa Integron Phyletically Related to In5, Which Carries an Unusual Array of Gene Cassettes. Antimicrobial Agents and Chemotherapy, 43 (4), 890-901. doi:10.1128/aac.43.4.890 ![]() |
![]() ![]() | Matagne, A., Dubus, A., Galleni, M., & Frère, J.-M. (February 1999). The Beta-Lactamase Cycle: A Tale of Selective Pressure and Bacterial Ingenuity. Natural Product Reports, 16 (1), 1-19. doi:10.1039/a705983c ![]() |
Frère, J.-M., Dubus, A., Galleni, M., Matagne, A., & Amicosante, G. (February 1999). Mechanistic Diversity of Beta-Lactamases. Biochemical Society Transactions, 27 (2), 58-63. doi:10.1042/bst0270058 ![]() |
![]() ![]() | Prosperi, C., Llabres, G., De Seny, D., Soto, R. P., Valladares, M. H., Laraki, N., Frère, J.-M., & Galleni, M. (25 January 1999). Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases. FEBS Letters, 443 (2), 109-11. doi:10.1016/S0014-5793(98)01689-5 ![]() |
![]() ![]() | Bompard-Gilles, C., Villeret, V., Fanuel, L., Joris, B., Frère, J.-M., & Van Beeumen, J. (1999). Crystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis. Acta Crystallographica. Section D, Biological Crystallography, 55 (Pt 3), 699-701. doi:10.1107/S0907444998015807 ![]() |
![]() ![]() | Laraki, N., Franceschini, N., Rossolini, G. M., Santucci, P., Meunier, C., De Pauw, E., Amicosante, G., Frère, J.-M., & Galleni, M. (1999). Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli. Antimicrobial Agents and Chemotherapy, 43 (4), 902-6. doi:10.1128/aac.43.4.902 ![]() |
![]() ![]() | Lakaye, B., Dubus, A., Lepage, S., Groslambert, S., & Frère, J.-M. (January 1999). When Drug Inactivation Renders the Target Irrelevant to Antibiotic Resistance: A Case Story with Beta-Lactams. Molecular Microbiology, 31 (1), 89-101. doi:10.1046/j.1365-2958.1999.01150.x ![]() |
![]() ![]() | Fanuel, L., Goffin, C., Cheggour, A., Devreese, B., Van Driessche, G., Joris, B., Van Beeumen, J., & Frère, J.-M. (1999). The DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family. Biochemical Journal, 341 (Pt 1), 147-55. doi:10.1042/0264-6021:3410147 ![]() |
![]() ![]() | Paul-Soto, R., Bauer, R., Frère, J.-M., Galleni, M., Meyer-Klaucke, W., Nolting, H., Rossolini, G. M., DE SENY, D., Hernandez-Valladares, M., Zeppezauer, M., & Adolph, H. W. (1999). Mono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism. Journal of Biological Chemistry, 274 (19), 13242-9. doi:10.1074/jbc.274.19.13242 ![]() |
Damblon, C., Prosperi, C., Lian, L. Y., Barsukov, I., Soto, R. P., Galleni, M., Frère, J.-M., & Roberts, G. C. K. (1999). H-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase. Journal of the American Chemical Society, 121 (49), 11575-11576. doi:10.1021/ja992896h ![]() |
![]() ![]() | Rossolini, G. M., Franceschini, N., Lauretti, L., Caravelli, B., Riccio, M. L., Galleni, M., Frère, J.-M., & Amicosante, G. (1999). Cloning of a Chryseobacterium (Flavobacterium) meningosepticum chromosomal gene (blaA(CME)) encoding an extended-spectrum class A beta-lactamase related to the Bacteroides cephalosporinases and the VEB-1 and PER beta-lactamases. Antimicrobial Agents and Chemotherapy, 43 (9), 2193-9. doi:10.1128/aac.43.9.2193 ![]() |
![]() ![]() | Fanuel, L., Thamm, I., Kostanjevecki, V., Samyn, B., Joris, B., Goffin, C., Brannigan, J., Van Beeumen, J., & Frère, J.-M. (1999). Two new aminopeptidases from Ochrobactrum anthropi active on D-alanyl-p-nitroanilide. Cellular and Molecular Life Sciences, 55 (5), 812-8. doi:10.1007/s000180050334 ![]() |
![]() ![]() | Paul-Soto, R., Zeppezauer, M., Adolph, H. W., Galleni, M., Frère, J.-M., Carfi, A., Dideberg, O., Wouters, J., Hemmingsen, L., & Bauer, R. (1999). Preference of Cd(II) and Zn(II) for the two metal sites in Bacillus cereus beta-lactamase II: A perturbed angular correlation of gamma-rays spectroscopic study. Biochemistry, 38 (50), 16500-6. doi:10.1021/bi9911381 ![]() |
![]() ![]() | Swaren, P., Maveyraud, L., Raquet, X., Cabantous, S., Duez, C., Pédelacq, J.-D., Maryotte-Boyer, S., Mourey, L., Labia, R., Nicolas-Chanoine, M.-H., Nordmann, P., Frère, J.-M., & Samama, J.-P. (09 October 1998). X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity. Journal of Biological Chemistry, 273 (41), 26714-26721. doi:10.1074/jbc.273.41.26714 ![]() |
Georis, J., De Lemos Esteves, F., Lamotte-Brasseur, J., Goossens, E., Bougnet, V., Giannotta, F., Granier, B., & Frère, J.-M. (May 1998). Structural basis and molecular study for the thermostability of the G/11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38 [Poster presentation]. Bioforum, Liège, Belgium. |
![]() ![]() | Matagne, A., Lamotte-Brasseur, J., & Frère, J.-M. (01 March 1998). Catalytic Properties of Class a Beta-Lactamases: Efficiency and Diversity. Biochemical Journal, 330 ((Pt 2)), 581-98. doi:10.1042/bj3300581 ![]() |
Carfi, A., Duee, E., Paul-Soto, R., Galleni, M., Frère, J.-M., & Dideberg, O. (1998). X-ray structure of the ZnII beta-lactamase from Bacteroides fragilis in an orthorhombic crystal form. Acta Crystallographica. Section D, Biological Crystallography, 54 (Pt 1), 45-57. doi:10.1107/s090744499700927x ![]() |
![]() ![]() | Pierrard, A., Ledent, P., Docquier, J.-D., Feller, G., Gerday, C., & Frère, J.-M. (1998). Inducible class C beta-lactamases produced by psychrophilic bacteria. FEMS Microbiology Letters, 161, 311-315. doi:10.1016/S0378-1097(98)00088-3 ![]() |
Charlier, P., Coyette, J., Dehareng, D., Dive, G., Duez, C., Dusart, J., Fonzé, E., Fraipont, C., Frère, J.-M., Galleni, M., Goffin, C., Joris, B., Lamotte-Brasseur, J., & Nguyen-Distèche, M. (1998). Résistance bactérienne aux beta-lactamines. MS. Medecine Sciences, 14 (5), 544-555. doi:10.4267/10608/1092 ![]() |
![]() ![]() | Paul-Soto, R., Hernandez-Valladares, M., Galleni, M., Bauer, R., Zeppezauer, M., Frère, J.-M., & Adolph, H. W. (1998). Mono- and binuclear Zn-beta-lactamase from Bacteroides fragilis: catalytic and structural roles of the zinc ions. FEBS Letters, 438 (1-2), 137-40. doi:10.1016/S0014-5793(98)01289-7 ![]() |
![]() ![]() | Rossolini, G. M., Franceschini, N., Riccio, M. L., Mercuri, P., Perilli, M., Galleni, M., Frère, J.-M., & Amicosante, G. (1998). Characterization and sequence of the Chryseobacterium (Flavobacterium) meningosepticum carbapenemase: a new molecular class B beta-lactamase showing a broad substrate profile. Biochemical Journal, 332 ( Pt 1), 145-52. doi:10.1042/bj3320145 ![]() |
![]() ![]() | Vanhove, M., Lejeune, A., GUILLAUME, G., Virden, R., Pain, R. H., Schmid, F. X., & Frère, J.-M. (1998). A collapsed intermediate with nonnative packing of hydrophobic residues in the folding of TEM-1 beta-lactamase. Biochemistry, 37 (7), 1941-1950. doi:10.1021/bi972143c ![]() |
![]() ![]() | Philippon, A., Dusart, J., Joris, B., & Frère, J.-M. (1998). The diversity, structure and regulation of beta-lactamases. Cellular and Molecular Life Sciences, 54 (4), 341-6. doi:10.1007/s000180050161 ![]() |
![]() ![]() | Zhao, G., Duez, C., Forceille, C., Rhazi, N., Klein, D., Ghuysen, J.-M., Frère, J.-M., & Lepage, S. (15 October 1997). Site-Directed Mutagenesis of the Actinomadura R39 DD-Peptidase. Biochemical Journal, 327 (2), 377-381. doi:10.1042/bj3270377 ![]() |
![]() ![]() | Adam, M., Fraipont, C., Rhazi, N., Nguyen-Disteche, M., Lakaye, B., Frère, J.-M., Devreese, B., Van Beeumen, J., van Heijenoort, Y., van Heijenoort, J., & Ghuysen, J.-M. (October 1997). The Bimodular G57-V577 Polypeptide Chain of the Class B Penicillin-Binding Protein 3 of Escherichia Coli Catalyzes Peptide Bond Formation from Thiolesters and Does Not Catalyze Glycan Chain Polymerization from the Lipid II Intermediate. Journal of Bacteriology, 179 (19), 6005-6009. doi:10.1128/jb.179.19.6005-6009.1997 ![]() |
![]() ![]() | Hernandez Valladares, M., Felici, A., Weber, G., Adolph, H. W., Zeppezauer, M., Rossolini, G. M., Amicosante, G., Frère, J.-M., & Galleni, M. (23 September 1997). Zn(Ii) Dependence of the Aeromonas Hydrophila Ae036 Metallo-Beta-Lactamase Activity and Stability. Biochemistry, 36 (38), 11534-41. doi:10.1021/bi971056h ![]() |
![]() ![]() | Quinting, B., Reyrat, J. M., Monnaie, D., Amicosante, G., Pelicic, V., Gicquel, B., Frère, J.-M., & Galleni, M. (14 April 1997). Contribution of Beta-Lactamase Production to the Resistance of Mycobacteria to Beta-Lactam Antibiotics. FEBS Letters, 406 (3), 275-8. doi:10.1016/S0014-5793(97)00286-X ![]() |
![]() ![]() | Quinting, B., Galleni, M., Timm, J., Gicquel, B., Amicosante, G., & Frère, J.-M. (01 April 1997). Purification and Properties of the Mycobacterium Smegmatis Mc(2)155 Beta-Lactamase. FEMS Microbiology Letters, 149 (1), 11-5. doi:10.1016/S0378-1097(97)00041-4 ![]() |
![]() ![]() | Felici, A., Perilli, M., Franceschini, N., Rossolini, G. M., Galleni, M., Frère, J.-M., Oratore, A., & Amicosante, G. (1997). Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases. Antimicrobial Agents and Chemotherapy, 41 (4), 866-8. doi:10.1128/aac.41.4.866 ![]() |
![]() ![]() | Perez-Llarena, F., Martin, J. F., Galleni, M., Coque, J. J., Fuente, J. L., Frère, J.-M., & Liras, P. (1997). The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity. Journal of Bacteriology, 179 (19), 6035-40. doi:10.1128/jb.179.19.6035-6040.1997 ![]() |
![]() ![]() | Guillaume, G., Vanhove, M., Lamotte-Brasseur, J., Ledent, P., Jamin, M., Joris, B., & Frère, J.-M. (1997). Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies. Journal of Biological Chemistry, 272 (9), 5438-44. doi:10.1074/jbc.272.9.5438 ![]() |
![]() ![]() | Ledent, P., Duez, C., Vanhove, M., Lejeune, A., Fonze, E., Charlier, P., Rhazi-Filali, F., Thamm, I., Guillaume, G., Samyn, B., Devreese, B., Van Beeumen, J., Lamotte-Brasseur, J., & Frère, J.-M. (1997). Unexpected Influence of a C-Terminal-Fused His-Tag on the Processing of an Enzyme and on the Kinetic and Folding Parameters. FEBS Letters, 413 (2), 194-196. doi:10.1016/S0014-5793(97)00908-3 ![]() |
![]() ![]() | Hardt, K., Joris, B., Lepage, S., Brasseur, R., Lampen, J. O., Frère, J.-M., Fink, A. L., & Ghuysen, J.-M. (1997). The Penicillin sensory transducer, blar, involved in the inducibility of beta-lactamase synthesis in bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle. Molecular Microbiology, 23 (5), 935-944. doi:10.1046/j.1365-2958.1997.2761642.x ![]() |
Hernandez Villadares, M., Galleni, M., Frère, J.-M., Felici, A., Perilli, M., Franceschini, N., Rossolini, G. M., Oratore, A., & Amicosante, G. (1996). Overproduction and purification of the Aeromonas hydrophila CphA metallo-beta-lactamase expressed in Escherichia coli. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 2 (2), 253-6. doi:10.1089/mdr.1996.2.253 ![]() |
![]() ![]() | Mainfroid, V., Terpstra, P., Beauregard, M., Frère, J.-M., Mande, S. C., Hol, W. G., Martial, J., & Goraj, K. (1996). Three hTIM mutants that provide new insights on why TIM is a dimer. Journal of Molecular Biology, 257 (2), 441-56. doi:10.1006/jmbi.1996.0174 ![]() |
Damblon, C., Raquet, X., Lian, L. Y., Lamotte, J., Fonze, E., Charlier, P., Roberts, G. C., & Frère, J.-M. (1996). The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme. Proceedings of the National Academy of Sciences of the United States of America, 93 (5), 1747-52. doi:10.1073/pnas.93.5.1747 ![]() |
![]() ![]() | Galleni, M., Lamotte-Brasseur, J., Raquet, X., Dubus, A., Monnaie, D., Knox, J. R., & Frère, J.-M. (11 May 1995). The Enigmatic Catalytic Mechanism of Active-Site Serine Beta-Lactamases. Biochemical Pharmacology, 49 (9), 1171-8. doi:10.1016/0006-2952(94)00502-D ![]() |
Lepage, S., Lakaye, B., Galleni, M., Thamm, I., Crine, M., Groslambert, S., & Frère, J.-M. (April 1995). Saturation of Penicillin-Binding Protein 1 by Beta-Lactam Antibiotics in Growing Cells of Bacillus Licheniformis. Molecular Microbiology, 16 (2), 365-72. doi:10.1111/j.1365-2958.1995.tb02308.x ![]() |
Jacobs, C., Joris, B., Jamin, M., Klarsov, K., Van Beeumen, J., Mengin-Lecreulx, D., van Heijenoort, J., Park, J. T., Normark, S., & Frère, J.-M. (February 1995). Ampd, Essential for Both Beta-Lactamase Regulation and Cell Wall Recycling, Is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase. Molecular Microbiology, 15 (3), 553-9. doi:10.1111/j.1365-2958.1995.tb02268.x ![]() |
Galleni, M., Raquet, X., Lamotte-Brasseur, J., Fonze, E., Amicosante, G., & Frère, J.-M. (February 1995). Dd-Peptidases and Beta-Lactamases: Catalytic Mechanisms and Specificities. Journal of Chemotherapy, 7 (1), 3-7. doi:10.1179/joc.1995.7.1.3 ![]() |
![]() ![]() | Matagne, A., & Frère, J.-M. (19 January 1995). Contribution of Mutant Analysis to the Understanding of Enzyme Catalysis: The Case of Class a Beta-Lactamases. Biochimica et Biophysica Acta, 1246 (2), 109-27. doi:10.1016/0167-4838(94)00177-I ![]() |
Damblon, C., Ledent, P., Zhao, G. H., Jamin, M., Dubus, A., Vanhove, M.-L., Raquet, X., Christiaens, L., & Frère, J.-M. (1995). Thiolester substrates of DD-peptidases and beta-lactamases. Letters in Peptide Science, 2 (3-4), 212-216. doi:10.1007/BF00119156 ![]() |
![]() ![]() | Grandchamps, J., Nguyen-Distèche, M., Damblon, C., Frère, J.-M., & Ghuysen, J.-M. (1995). Streptomyces K15 active-site serine DD-transpeptidase: specificity profile for peptide, thiol ester and ester carbonyl donors and pathways of the transfer reactions. Biochemical Journal, 307 (Pt 2), 335-339. doi:10.1042/bj3070335 ![]() |
![]() ![]() | Carfi, A., Pares, S., Duée, E., Galleni, M., Duez, C., Frère, J.-M., & Dideberg, O. (1995). The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold. EMBO Journal, 14 (20), 4914-4921. doi:10.1002/j.1460-2075.1995.tb00174.x ![]() |
![]() ![]() | Matagne, A., Ledent, P., Monnaie, D., Felici, A., Jamin, M., Raquet, X., Galleni, M., Klein, D., Francois, I., & Frère, J.-M. (January 1995). Kinetic Study of Interaction between Brl 42715, Beta-Lactamases, and D-Alanyl-D-Alanine Peptidases. Antimicrobial Agents and Chemotherapy, 39 (1), 227-31. doi:10.1128/aac.39.1.227 ![]() |
![]() ![]() | Fonze, E., Charlier, P., To'th, Y., Vermeire, M., Raquet, X., Dubus, A., & Frère, J.-M. (1995). TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant. Acta Crystallographica. Section D, Biological Crystallography, 51 (Pt 5), 682-94. doi:10.1107/S0907444994014496 ![]() |
Damblon, C., Zhao, G. H., Jamin, M., Ledent, P., Dubus, A., Vanhove, M.-L., Raquet, X., Christiaens, L., & Frère, J.-M. (1995). Breakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates. Biochemical Journal, 309 ( Pt 2), 431-6. doi:10.1042/bj3090431 ![]() |
Lepage, S., Galleni, M., Lakaye, B., Joris, B., Thamm, I., & Frère, J.-M. (1995). Kinetic properties of the Bacillus licheniformis Penicillin-binding proteins. Biochemical Journal, 309, 49-53. doi:10.1042/bj3090049 ![]() |
![]() ![]() | Duez, C., Piron-Fraipont, C., Joris, B., Dusart, J., Urdea, M.-S., Martial, J., Frère, J.-M., & Ghuysen, J.-M. (15 September 1994). Erratum for : primary structure of the streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene. European Journal of Biochemistry, 224 (3), 1079. doi:10.1111/j.1432-1033.1994.01079.x ![]() |
![]() ![]() | Fanuel, L., Granier, B., Wilkin, J.-M., Bellefroid-Bourguignon, C., Joris, B., Knowles, J., Komives, E., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (29 August 1994). The Precursor of the Streptomyces R61 Dd-Peptidase Containing a C-Terminal Extension Is Inactive. FEBS Letters, 351 (1), 49-52. doi:10.1016/0014-5793(94)00822-1 ![]() |
![]() ![]() | Galleni, M., Franceschini, N., Quinting, B., Fattorini, L., Orefici, G., Oratore, A., Frère, J.-M., & Amicosante, G. (July 1994). Use of the Chromosomal Class a Beta-Lactamase of Mycobacterium Fortuitum D316 to Study Potentially Poor Substrates and Inhibitory Beta-Lactam Compounds. Antimicrobial Agents and Chemotherapy, 38 (7), 1608-14. doi:10.1128/AAC.38.7.1608 ![]() |
![]() ![]() | Timm, J., Perilli, M. G., Duez, C., Trias, J., Orefici, G., Fattorini, L., Amicosante, G., Oratore, A., Joris, B., & Frère, J.-M. (1994). Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer. Molecular Microbiology, 12 (3), 491-504. doi:10.1111/j.1365-2958.1994.tb01037.x ![]() |
Lakaye, B., Damblon, C., Jamin, M., Galleni, M., Lepage, S., Joris, B., Marchand-Brynaert, J., Frydrychh, C., & Frère, J.-M. (1994). Synthesis, purification and kinetic properties of fluorescein-labelled penicillins. Biochemical Journal, 300, 141-145. doi:10.1042/bj3000141 ![]() |
STRYNADKA, N. C. J., JENSEN, S. E., JOHNS, K., BLANCHARD, H., PAGE, M., Matagne, A., Frère, J.-M., & JAMES, M. N. G. (1994). STRUCTURAL AND KINETIC CHARACTERIZATION OF A BETA-LACTAMASE-INHIBITOR PROTEIN. Nature, 368 (6472), 657-660. doi:10.1038/368657a0 ![]() |
![]() ![]() | Joris, B., Galleni, M., Frère, J.-M., & Labia, R. (1994). Analysis of the penA gene of Pseudomonas cepacia 249. Antimicrobial Agents and Chemotherapy, 38 (2), 407-8. doi:10.1128/AAC.38.2.407 ![]() |
![]() ![]() | Wilkin, J. M., Dubus, A., Joris, B., & Frère, J.-M. (1994). The mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase. Biochemical Journal, 301 ( Pt 2), 477-83. doi:10.1042/bj3010477 ![]() |
![]() ![]() | Datz, M., Joris, B., Azab, E. A., Galleni, M., Van Beeumen, J., Frère, J.-M., & Martin, H. H. (1994). A common system controls the induction of very different genes. The class-A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-lactamase. European Journal of Biochemistry, 226 (1), 149-57. doi:10.1111/j.1432-1033.1994.tb20036.x ![]() |
Jamin, M., Damblon, C., Bauduin-Misselyn, A. M., Durant, F., Roberts, G. C., Charlier, P., Llabres, G., & Frère, J.-M. (1994). Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase. Biochemical Journal, 301 ( Pt 1), 199-203. doi:10.1042/bj3010199 ![]() |
Lamotte, J., Knox, J., Kelly, J. A., Charlier, P., Fonze, E., Dideberg, O., & Frère, J.-M. (1994). The structures and catalytic mechanisms of active-site serine beta-lactamases. Biotechnology and Genetic Engineering Reviews, 12, 189-230. doi:10.1080/02648725.1994.10647912 ![]() |
![]() ![]() | Granier, B., Jamin, M., Adam, M., Galleni, M., Lakaye, B., Zorzi, W., Grandchamps, J., Wilkin, J.-M., Fraipont, C., Joris, B., Duez, C., Nguyen-Distèche, M., Coyette, J., Leyh-Bouille, M., Dusart, J., Christians, L., Frère, J.-M., & Ghuysen, J.-M. (1994). Serine-Type D-Ala-D-Ala Peptidases and Penicillin-Binding Proteins. Methods in Enzymology, 244, 249-266. doi:10.1016/0076-6879(94)44021-2 ![]() |
![]() ![]() | Matagne, A., Ghuysen, M. F., & Frère, J.-M. (01 November 1993). Interactions between Active-Site-Serine Beta-Lactamases and Mechanism-Based Inactivators: A Kinetic Study and an Overview. Biochemical Journal, 295 ((Pt 3)), 705-711. doi:10.1042/bj2950705 ![]() |
![]() ![]() | Matagne, A., Lamotte-Brasseur, J., & Frère, J.-M. (01 October 1993). Interactions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies. European Journal of Biochemistry, 217 (1), 61-67. doi:10.1111/j.1432-1033.1993.tb18218.x ![]() |
![]() ![]() | Matagne, A., Lamotte-Brasseur, J., Dive, G., Knox, J. R., & Frère, J.-M. (01 August 1993). Interactions between Active-Site-Serine Beta-Lactamases and Compounds Bearing a Methoxy Side Chain on the Alpha-Face of the Beta-Lactam Ring: Kinetic and Molecular Modelling Studies. Biochemical Journal, 293 ((Pt 3)), 607-611. doi:10.1042/bj2930607 ![]() |
![]() ![]() | Wilkin, J.-M., Jamin, M., Damblon, C., Zhao, G.-H., Joris, B., Duez, C., & Frère, J.-M. (15 April 1993). The Mechanism of Action of DD-Peptidases: The Role of Tyrosine-159 in the Streptomyces R61 DD-Peptidase. Biochemical Journal, 291 (Part 2), 537-544. doi:10.1042/bj2910537 ![]() |
![]() ![]() | Galleni, M., Lakaye, B., Lepage, S., Jamin, M., Thamm, I., Joris, B., & Frère, J.-M. (01 April 1993). A New, Highly Sensitive Method for the Detection and Quantification of Penicillin-Binding Proteins. Biochemical Journal, 291 ((Pt 1)), 19-21. doi:10.1042/bj2910019 ![]() |
JAMIN, M., Damblon, C., MILLIER, S., HAKENBECK, R., & Frère, J.-M. (1993). PENICILLIN-BINDING PROTEIN 2X OF STREPTOCOCCUS-PNEUMONIAE - ENZYMATIC-ACTIVITIES AND INTERACTIONS WITH BETA-LACTAMS. Biochemical Journal, 292 (Part 3), 735-741. doi:10.1042/bj2920735 ![]() |
![]() ![]() | Wilkin, J. M., Jamin, M., Joris, B., & Frère, J.-M. (1993). Mechanism of action of DD-peptidases: role of asparagine-161 in the Streptomyces R61 DD-peptidase. Biochemical Journal, 293 ( Pt 1), 195-201. doi:10.1042/bj2930195 ![]() |
![]() ![]() | Felici, A., Amicosante, G., Oratore, A., Strom, R., Ledent, P., Joris, B., Fanuel, L., & Frère, J.-M. (1993). An overview of the kinetic parameters of class B beta-lactamases. Biochemical Journal, 291 ( Pt 1), 151-5. doi:10.1042/bj2910151 ![]() |
![]() ![]() | Ledent, P., Raquet, X., Joris, B., Van Beeumen, J., & Frère, J.-M. (1993). A comparative study of class-D beta-lactamases. Biochemical Journal, 292 ( Pt 2), 555-62. doi:10.1042/bj2920555 ![]() |
![]() ![]() | Franceschini, N., Galleni, M., Frère, J.-M., Oratore, A., & Amicosante, G. (1993). A class-A beta-lactamase from Pseudomonas stutzeri that is highly active against monobactams and cefotaxime. Biochemical Journal, 292 ( Pt 3), 697-700. doi:10.1042/bj2920697 ![]() |
![]() ![]() | Hadonou, A. M., Wilkin, J.-M., Varetto, L., Joris, B., Lamotte-Brasseur, J., Klein, D., Duez, C., Ghuysen, J.-M., & Frère, J.-M. (01 July 1992). Site-Directed Mutagenesis of the Streptomyces R61 Dd-Peptidase. Catalytic Function of the Conserved Residues around the Active Site and a Comparison with Class-a and Class-C Beta-Lactamases. European Journal of Biochemistry, 207 (1), 97-102. doi:10.1111/j.1432-1033.1992.tb17025.x ![]() |
![]() ![]() | Bourguignon-Bellefroid, C., Joris, B., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (01 April 1992). Point Mutations of Two Arginine Residues in the Streptomyces R61 Dd-Peptidase. Biochemical Journal, 283 (1), 123-128. doi:10.1042/bj2830123 ![]() |
![]() ![]() | Granier, B., Duez, C., Englebert, S., Dusart, J., Dideberg, O., Van Beeumen, J., Frère, J.-M., Ghuysen, J.-M., & Lepage, S. (15 March 1992). Primary and Predicted Secondary Structures of the Actinomadura R39 Extracellular DD-Peptidase, a Penicillin-Binding Protein (PBP) Related to the Escherichia coli PBP4. Biochemical Journal, 282 (Pt 3), 781-788. doi:10.1042/bj2820781 ![]() |
![]() ![]() | Bourguignon-Bellefroid, C., Wilkin, J.-M., Joris, B., Aplin, R. T., Houssier, C., Prendergast, F. G., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (01 March 1992). Importance of the Two Tryptophan Residues in the Streptomyces R61 Exocellular Dd-Peptidase. Biochemical Journal, 282 (Pt 2), 361-367. doi:10.1042/bj2820361 ![]() |
![]() ![]() | Hadonou, A. M., Jamin, M., Adam, M., Joris, B., Dusart, J., Ghuysen, J.-M., & Frère, J.-M. (01 March 1992). Importance of the His-298 Residue in the Catalytic Mechanism of the Streptomyces R61 Extracellular Dd-Peptidase. Biochemical Journal, 282 (Pt 2), 495-500. doi:10.1042/bj2820495 ![]() |
![]() ![]() | Lamotte-Brasseur, J., Jacob-Dubuisson, F., Dive, G., Frère, J.-M., & Ghuysen, J.-M. (10 February 1992). Streptomyces albus G serine β-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes. Biochemical Journal, 282 (Pt 1), 189-195. doi:10.1042/bj2820189 ![]() |
![]() ![]() | Granier, B., Duez, C., Lepage, S., Englebert, S., Dusart, J., Dideberg, O., Van Baumeen, J., Frère, J.-M., & Ghuysen, J.-M. (1992). Correction: Primary and predicted secondary structure of the actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the escherichia coli PBP4 (Biochemical Journal(1992)282(786)). Biochemical Journal, 282 (Part 3), 981-982. doi:10.1042/bj2860981c ![]() |
![]() ![]() | Pirotte, B., Dive, G., Delarge, J., Masereel, B., Dupont, L., Thunus, L., Schynts, M., Coyette, J., & Frère, J.-M. (1992). Synthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques b-lactamiques. European Journal of Medicinal Chemistry, 27 (3), 193-205. doi:10.1016/0223-5234(92)90003-J ![]() |
![]() ![]() | Matagne, A., Joris, B., & Frère, J.-M. (01 December 1991). Anomalous Behaviour of a Protein During Sds/Page Corrected by Chemical Modification of Carboxylic Groups. Biochemical Journal, 280 ((Pt 2)), 553-6. doi:10.1042/bj2800553 ![]() |
![]() ![]() | Joris, B., Ledent, P., Dideberg, O., Fonze, E., Lamotte-Brasseur, J., Kelly, J. A., Ghuysen, J.-M., & Frère, J.-M. (November 1991). Comparison of the Sequences of Class a β-lactamase and of the Secondary Structure Elements of Penicillin-Recognizing Proteins. Antimicrobial Agents and Chemotherapy, 35 (11), 2294-2301. doi:10.1128/AAC.35.11.2294 ![]() |
![]() ![]() | Lamotte-Brasseur, J., Dive, G., Dideberg, O., Charlier, P., Frère, J.-M., & Ghuysen, J.-M. (01 October 1991). Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G. Biochemical Journal, 279 (Pt 1), 213-221. doi:10.1042/bj2790213 ![]() |
Varetto, L., De Meester, F., Monnaie, D., Marchand-Brynaert, J., Dive, G., Jacob, F., & Frère, J.-M. (15 September 1991). The Importance of the Negative Charge of Beta-Lactam Compounds in the Interactions with Active-Site Serine Dd-Peptidases and Beta-Lactamases. Biochemical Journal, 278 (Pt 3), 801-807. doi:10.1042/bj2780801 ![]() |
![]() ![]() | Jacob, F., Joris, B., & Frère, J.-M. (01 August 1991). Active-Site Serine Mutants of the Streptomyces Albus G Beta-Lactamase. Biochemical Journal, 277 ((Pt 3)), 647-52. doi:10.1042/bj2770647 ![]() |
![]() ![]() | Ambler, R. P., Coulson, A. F. W., Frère, J.-M., Ghuysen, J.-M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., & Waley, S. G. (15 May 1991). A standard numbering scheme for the class A beta-lactamases. Biochemical Journal, 276 (Pt 1), 269-270. doi:10.1042/bj2760269 ![]() |
![]() ![]() | Matagne, A., Joris, B., Van Beeumen, J., & Frère, J.-M. (01 February 1991). Ragged N-Termini and Other Variants of Class a Beta-Lactamases Analysed by Chromatofocusing. Biochemical Journal, 273 (273), 503-10. doi:10.1042/bj2730503 ![]() |
JAMIN, M., Adam, M., Damblon, C., Christiaens, L., & Frère, J.-M. (1991). ACCUMULATION OF ACYL-ENZYME IN DD-PEPTIDASE-CATALYZED REACTIONS WITH ANALOGS OF PEPTIDE-SUBSTRATES. Biochemical Journal, 280 (Part 2), 499-506. doi:10.1042/bj2800499 ![]() |
![]() ![]() | BRANNIGAN, J., Matagne, A., Jacob, F., Damblon, C., Joris, B., KLEIN, D., SPRATT, B. G., & Frère, J.-M. (1991). THE MUTATION LYS234HIS YIELDS A CLASS-A BETA-LACTAMASE WITH A NOVEL PH-DEPENDENCE. Biochemical Journal, 278 (Part 3), 673-678. doi:10.1042/bj2780673 ![]() |
Frère, J.-M., Joris, B., Granier, B., Matagne, A., Ackerman, F., & Bourguignon-Bellefroid, C. (1991). Diversity of the Mechanisms of Resistance to Beta-Lactam Antibiotics. Research in Microbiology, 142 (6, Jul-Aug), 705-10. doi:10.1016/0923-2508(91)90084-N ![]() |
![]() ![]() | Adam, M., Damblon, C., Jamin, M., Zorzi, W., Dusart, V., Galleni, M., El Kharroubi, A., Piras, G., Spratt, B. G., Keck, W., Coyette, J., Ghuysen, J.-M., NGuyen-Distèche, M., & Frère, J.-M. (1991). Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochemical Journal, 279 (Part 2), 601-604. doi:10.1042/bj2790601 ![]() |
Frère, J.-M., Joris, B., Jacob, F., Matagne, A., Monnaie, D., Jamin, M., Hadonou, M., Bourguignon-Bellefroid, C., Varetto, L., Wilkin, J.-M., Dubus, A., Damblon, C., Adam, M., Ledent, P., De Meester, F., & Galleni, M. (1991). Mechanism of action of β-lactamases and DD-peptidases. In U. K. Pandit & F. C. Alderweireldt (Eds.), Bioorganic Chemistry in Healthcare and Technology (pp. 161-170). New York, United States - New York: Plenum Press. ![]() |
![]() ![]() | Pirotte, B., Delarge, J., Coyette, J., & Frère, J.-M. (1991). Antibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to β-lactam antibiotics. Journal of Antibiotics, 44, 844-853. doi:10.7164/antibiotics.44.844 ![]() |
Perilli, M., Franceschini, N., Segatore, B., Amicosante, G., Oratore, A., Duez, C., Joris, B., & Frère, J.-M. (1991). Cloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus. FEMS Microbiology Letters, 83, 79-84. doi:10.1111/j.1574-6968.1991.tb04393.x ![]() |
![]() ![]() | Jacob, F., Joris, B., Lepage, S., Dusart, J., & Frère, J.-M. (15 October 1990). Role of the Conserved Amino Acids of the 'Sdn' Loop (Ser130, Asp131 and Asn132) in a Class a Beta-Lactamase Studied by Site-Directed Mutagenesis. Biochemical Journal, 271 (2), 399-406. doi:10.1042/bj2710399 ![]() |
![]() ![]() | Jacob, F., Joris, B., Dideberg, O., Dusart, J., Ghuysen, J.-M., & Frère, J.-M. (October 1990). Engineering a Novel β-Lactamase by a Single Point Mutation. Protein Engineering, 4 (1), 79-86. doi:10.1093/protein/4.1.79 ![]() |
![]() ![]() | Matagne, A., Misselyn-Bauduin, A. M., Joris, B., Erpicum, T., Granier, B., & Frère, J.-M. (01 January 1990). The Diversity of the Catalytic Properties of Class a Beta-Lactamases. Biochemical Journal, 265 (1), 131-46. doi:10.1042/bj2650131 ![]() |
Adam, M., Damblon, C., PLAITIN, B., Christiaens, L., & Frère, J.-M. (1990). CHROMOGENIC DEPSIPEPTIDE SUBSTRATES FOR BETA-LACTAMASES AND PENICILLIN-SENSITIVE DD-PEPTIDASES. Biochemical Journal, 270 (2), 525-529. doi:10.1042/bj2700525 ![]() |
![]() ![]() | Moews, P. C., Knox, J. R., Dideberg, O., Charlier, P., & Frère, J.-M. (1990). Beta-lactamase of Bacillus licheniformis 749/C at 2 A resolution. Proteins, 7 (2), 156-71. doi:10.1002/prot.340070205 ![]() |
![]() ![]() | Houba, S., Willem, S., Duez, C., Molitor, C., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (December 1989). Nucleotide sequence of the gene encoding the active-site serine β-lactamase from Actinomadura R39. FEMS Microbiology Letters, 65 (3), 241-246. doi:10.1111/j.1574-6968.1989.tb03667.x ![]() |
Frère, J.-M., Joris, B., Crine, M., & Martin, H. H. (01 May 1989). Quantitative Relationship between Sensitivity to Beta-Lactam Antibiotics and Beta-Lactamase Production in Gram-Negative Bacteria--II. Non-Steady-State Treatment and Progress Curves. Biochemical Pharmacology, 38 (9), 1427-33. doi:10.1016/0006-2952(89)90181-0 ![]() |
![]() ![]() | De Meester, F., Matagne, A., Dive, G., & Frère, J.-M. (01 January 1989). Unexpected Influence of Ionic Strength on Branched-Pathway Interactions between Beta-Lactamases and Beta-Halogenopenicillanates. Biochemical Journal, 257 (1), 245-9. doi:10.1042/bj2570245 ![]() |
![]() ![]() | Kelly, J. A., Knox, J. R., Zhao, H. C., Frère, J.-M., & Ghuysen, J.-M. (1989). Crystallographic mapping of β-lactams bound to a D-alanyl-D-alanine peptidase target enzyme. Journal of Molecular Biology, 209 (2), 281-295. doi:10.1016/0022-2836(89)90277-5 ![]() |
![]() ![]() | Fraipont, C., Duez, C., Matagne, A., Molitor, C., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (1989). Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular β-lactamase of Actinomadura R39. Biochemical Journal, 262 (3), 849-854. doi:10.1042/bj2620849 ![]() |
![]() ![]() | Galleni, M., Amicosante, G., & Frère, J.-M. (01 October 1988). A Survey of the Kinetic Parameters of Class C Beta-Lactamases. Cephalosporins and Other Beta-Lactam Compounds. Biochemical Journal, 255 (1), 123-9. doi:10.1042/bj2550123 ![]() |
![]() ![]() | Galleni, M., & Frère, J.-M. (01 October 1988). A Survey of the Kinetic Parameters of Class C Beta-Lactamases. Penicillins. Biochemical Journal, 255 (1), 119-22. doi:10.1042/bj2550119 ![]() |
Galleni, M., Lindberg, F., Normark, S., Cole, S., Honore, N., Joris, B., & Frère, J.-M. (15 March 1988). Sequence and Comparative Analysis of Three Enterobacter Cloacae Ampc Beta-Lactamase Genes and Their Products. Biochemical Journal, 250 (3), 753-60. doi:10.1042/bj2500753 ![]() |
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Kelly, J. A., Knox, J. R., Moews, P. C., Frère, J.-M., & Ghuysen, J.-M. (01 March 1988). Using X-ray diffraction results and computer graphics to design beta-lactams. Kansenshogaku zasshi, 62 Suppl, 182-191. ![]() |
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Frère, J.-M., & Joris, B. (1988). Beta-Lactamases as the Main Resistance Factor to Penicillin-Related Antibiotics. Annales de Biologie Clinique, 46 (2), 151-6. ![]() |
![]() ![]() | Amicosante, G., Oratore, A., Joris, B., Galleni, M., Frère, J.-M., & Van Beeumen, J. (1988). Chromosome-encoded beta-lactamases of Citrobacter diversus. Interaction with beta-iodopenicillanate and labelling of the active site. Biochemical Journal, 254 (3), 891-3. doi:10.1042/bj2540891 ![]() |
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Frère, J.-M., Adriaens, P., Degelaen, J., Vanderhaeghe, H., & Ghuysen, J.-M. (01 December 1975). Degradation of benzylpenicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R 61. Archives Internationales de Physiologie et de Biochimie, 83 (5), 905-907. doi:10.3109/13813457509069522 ![]() |
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