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• Selected spectral data for M1AOALys isomer 12a (R=(CH 2)4NH2): 1H NMR (500 MHz, DMSO) δ 12.75 (br s, 1H, COOH), 8.47 (s, 1H, H-20 oxazole), 7.89 (d, 1H, J = 8.0 Hz, CONHC), 7.80 (dd, 1H, J = 7.4 Hz, J = 4.2 Hz, NH-8), 7.65 (br s, 2H, NH2), 6.58 (dd, 1H, J = 16.0 Hz, J = 6.7 Hz, H-5), 6.26 (t, 1H, J = 2.9 Hz, H-26), 5.91 (d, 1H, H-6), 5.83 (d, 1H, J = 15.8 Hz, H-11), 5.56 (ddd, 1H, J = 3.8 Hz, J = 6.0 Hz, H-10), 5.04 (d, 1H, J = 8.5 Hz, H-13), 4.76 (dd, 1H, J = 1.8 Hz, J = 9.8 Hz, H-3), 4.58 (dt, 1H, J = 8.5 Hz, J = 4.6 Hz, H-14), 4.53 (d, 1H, J = 15.2 Hz, HAb), 4.44 (d, 1H, HAb), 4.28-4.25 (m, 1H, HD), 4.22 (d, 1H, J = 15.6 Hz, H-17a), 4.01-4.19 (m, 3H, H-9a, H-24), 3.71 (d, 1H, H-17b), 3.67 (br d, 1H, H-9b), 2.67-2.79 (m, 5H, H-4, H-25, HH), 2.56 (dd, 1H, J = 14.4 Hz, H-15a), 2.45 (dr d, 1H, H-15b), 1.91-1.97 (m, 1H, H-29), 1.80-1.74 (m, 1H, HEa), 1.63-1.68 (m, 4H, H-33, HEb), 1.56-1.49 (m, 2H, HG), 1.36-1.30 (m, 2H, HF), 1.06 (d, 3H, J = 6.9 Hz, H-32), 0.95 (d, 3H, J = 6.7 Hz, H-30), 0.88 (d, 3H, J = 6.7 Hz, H-31). 13C NMR (125 MHz, DMSO) δ 173.2 (COOH), 168.5 (CBONH), 165.0 (C-7), 160.1 (C-22), 160.0 (C-1), 158.3 (C-18), 152.3 (C-16), 144.9 (C-20), 143.3 (C-5), 136.1 (C-27), 135.2 (C-21), 133.5 (C-13), 133.3 (C-11), 132.6 (C-12), 125.2 (C-10), 125.0 (C-26), 124.8 (C-6), 80.2 (C-3), 72.2 (CA), 65.0 (C-14), 51.1 (CD), 50.5 (C-24), 40.9 (C-15), 39.3 (C-9), 38.6 (CH), 36.6 (C-4), 30.3 (CE), 29.7 (C-25), 29.1 (C-29), 28.1 (C-17), 26.4 (CG), 22.2 (CF), 19.3 (C-30), 18.6 (C-31), 12.7 (C-33), 11.6 (C-32). ESI MS: m/z = 709 [M-H2O+H+], 727 [M+H +], 749 [M+Na+].
• Selected spectral data for M1AOALys isomer 12b (R=(CH 2)4NH2): 1H NMR (500 MHz, DMSO) δ 8.40 (s, 1H, H-20 oxazole), 7.98 (d, 1H, J = 8.0 Hz, CONHc), 7.82 (dd, 1H, J = 8.2 Hz, J = 3.5 Hz, NH-8), 7.66 (br s, 2H, NH2), 6.58 (dd, 1H, J = 16.1 Hz, J = 7.6 Hz, H-5), 6.24 (td, 1H, J = 2.9 Hz, H-26), 5.93 (d, 1H, H-6), 5.68 (d, 1H, J = 16.0 Hz, H-11), 5.55 (dt, 1H, J = 4.0 Hz, J = 4.0 Hz, H-10), 4.90 (td, 1H, J = 9.2 Hz, J = 4.5 Hz, H-14), 4.78 (d, 1H, J = 1.5 Hz, J = 10.0 Hz, H-3), 4.66 (d, 1H, H-13), 4.53 (s, 2H, HA), 4.19-4.32 (m, 3H, HD, H-24), 4.13 (td, 1H, J = 9.9 Hz, H-9a), 3.68 (br d, 1H, H-9b), 3.64 (s, 2H, H-17), 2.99 (dd, 1H, H-15a), 2.64-2.86 (m, 5H, H H, H-4, H-25), 2.27 (dd, 1H, H-15b), 1.93-1.99 (m, 1H, H-29), 1.80-1.73 (m, 1H, HEa), 1.68-1.60 (m, 1H, HEb), 1.51-1.56 (m, 5H, H-33, HG), 1.37-1.37 (m, 2H, HF), 1.04 (d, 3H, J = 6.9 Hz, H-32), 0.95 (d, 3H, J = 6.7 Hz, H-30), 0.90 (d, 3H, J = 6.5 Hz, H-31). 13C NMR (125 MHz, DMSO) δ 173.2 (COOH), 168.4 (C BONH), 165.5 (C-7), 160.4 (C-22), 160.3 (C-1), 158.4 (C-18), 153.6 (C-16), 146.4 (C-20), 143.0 (C-5), 136.0 (C-27), 134.9 (C-21), 132.8 (C-12), 132.6 (C-13), 132.2 (C-11), 125.3 (C-10), 125.1 (C-6), 123.4 (C-26), 80.5 (C-3), 72.2 (CA), 67.0 (C-14), 51.2 (CD), 50.3 (C-24), 39.0 (C-9), 38.6 (CH), 37.3 (C-15), 36.7 (C-4), 34.2 (C-17), 30.5 (C E), 29.8 (C-25), 29.3 (C-29), 26.5 (CG), 22.3 (C F), 19.6 (C-30), 19.3 (C-31), 12.4 (C-33), 12.0 (C-32).
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