Article (Scientific journals)
Mucosal junctions: open doors to HPV and HIV infections?
Herfs, Michael; Hubert, Pascale; Moutschen, Michel et al.
2011In Trends in Microbiology, 19 (3), p. 114-120
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Abstract :
[en] Throughout adult life, new developmental commitment of adult stem cells causes reversible epithelial replacements in various mucosal surfaces, including the uterine cervix and the anal canal. Located at the squamocolumnar junctions, these metaplastic conversions are associated with chronic inflammation and deregulated expression of soluble and cell-membrane factors important for antiviral immune response. In this paper, we propose that these histological and immunological features increase the susceptibility of these metaplastic microenvironments to human papillomavirus and human immunodeficiency virus infections. Identification of the anatomical sites and cell populations within the anogenital tract, which is the site primary infected by these viruses, is crucial for the understanding of the pathogenesis of viral disease and development of antiviral strategies.
Research center :
Giga-Cancer - ULiège
Disciplines :
Oncology
Immunology & infectious disease
Author, co-author :
Herfs, Michael ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Hubert, Pascale  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Moutschen, Michel  ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Language :
English
Title :
Mucosal junctions: open doors to HPV and HIV infections?
Publication date :
07 January 2011
Journal title :
Trends in Microbiology
ISSN :
0966-842X
eISSN :
1878-4380
Publisher :
Elsevier Trends Journals, Cambridge, United Kingdom
Volume :
19
Issue :
3
Pages :
114-120
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
Copyright A(c) 2010 Elsevier Ltd. All rights reserved.
Available on ORBi :
since 22 February 2011

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