Doubling dolutegravir dosage reduces HIV persistence markers in ART-treated adults

Fombellida-Lopez, Céline; Pasternak, Alexander O.; Cicilionyté, Aurelija; Maes, Nathalie; Vanwinge, Céline; Ormenese, Sandra; Ladang, Aurélie; Cavalier, Etienne; Winchester, Lee; Fletcher, Courtney; SUSIN, Fabrice; VAIRA, Dolorès; Hayette, Marie-Pierre; Reenaers, Catherine; Moutschen, Michel; Darcis, Gilles

No full text

Poster (Scientific congresses and symposiums)

Doubling dolutegravir dosage reduces HIV persistence markers in ART-treated adults

Fombellida-Lopez, Céline; Pasternak, Alexander O.; Cicilionyté, Aurelija et al.

2023 • HIV Cure Symposium 2023

Permalink
https://hdl.handle.net/2268/308347

Files (0)Send to Details Statistics Bibliography Similar publications

Files

Full Text

No document available.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

HIV reservoirs; Treatment intensification; Residual viremia

Abstract :

[en] Whether ongoing viral replication occurs in people living with HIV (PLWH) despite antiretroviral therapy (ART) and leads to low-level residual viremia is still debated. Here we report on a study, in which we intensified the ART regimen by doubling dolutegravir (DTG) dosage. We investigated the impact of this strategy on HIV blood and tissue latent reservoirs, residual viremia, immune activation, and inflammation.

Disciplines :

Immunology & infectious disease

Author, co-author :

Fombellida-Lopez, Céline ; Université de Liège - ULiège > Département des sciences cliniques

Pasternak, Alexander O.; UvA - University of Amsterdam [NL]

Cicilionyté, Aurelija; UvA - University of Amsterdam [NL]

Maes, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)

Vanwinge, Céline ; Université de Liège - ULiège > GIGA > GIGA Platform Imaging & Flow cytometry

Ormenese, Sandra ; Université de Liège - ULiège > GIGA > GIGA Platform Imaging & Flow cytometry

Ladang, Aurélie ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Winchester, Lee; University of Nebraska

Fletcher, Courtney; University of Nebraska

More authors (6 more)

Language :

English

Title :

Doubling dolutegravir dosage reduces HIV persistence markers in ART-treated adults

Publication date :

11 September 2023

Event name :

HIV Cure Symposium 2023

Event place :

Gand, Belgium

Event date :

11/09/2023 au 12/09/2023

Available on ORBi :

since 31 October 2023

Statistics

Number of views

42 (6 by ULiège)

Number of downloads

0 (0 by ULiège)

More statistics