Doubling dolutegravir dosage reduces HIV persistence markers in ART-treated adults

Fombellida-Lopez, Céline; Pasternak, Alexander O.; Cicilionyté, Aurelija; Maes, Nathalie; Vanwinge, Céline; Ormenese, Sandra; Ladang, Aurélie; Cavalier, Etienne; Winchester, Lee; Fletcher, Courtney; SUSIN, Fabrice; VAIRA, Dolorès; Hayette, Marie-Pierre; Reenaers, Catherine; Moutschen, Michel; Darcis, Gilles

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Doubling dolutegravir dosage reduces HIV persistence markers in ART-treated adults

Fombellida-Lopez, Céline; Pasternak, Alexander O.; Cicilionyté, Aurelija et al.

2022 • Belgium Research on AIDS and HIV Consortium (BREACH 2022)

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https://hdl.handle.net/2268/308345

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Keywords :

HIV reservoirs; Treatment intensification; Residual viremia

Abstract :

[en] Whether ongoing viral replication occurs in people living with HIV (PLWH) despite antiretroviral therapy (ART) and leads to low-level residual viremia is still debated. Here we report on a study, in which we intensified the ART regimen by doubling dolutegravir (DTG) dosage. We investigated the impact of this strategy on HIV blood and tissue latent reservoirs, residual viremia, immune activation, and inflammation.

Disciplines :

Immunology & infectious disease

Author, co-author :

Fombellida-Lopez, Céline ; Université de Liège - ULiège > Département des sciences cliniques

Pasternak, Alexander O.; UvA - University of Amsterdam [NL]

Cicilionyté, Aurelija; UvA - University of Amsterdam [NL]

Maes, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)

Vanwinge, Céline ; Université de Liège - ULiège > GIGA > GIGA Platform Imaging & Flow cytometry

Ormenese, Sandra ; Université de Liège - ULiège > GIGA > GIGA Platform Imaging & Flow cytometry

Ladang, Aurélie ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Winchester, Lee; University of Nebraska

Fletcher, Courtney; University of Nebraska

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Language :

English

Title :

Doubling dolutegravir dosage reduces HIV persistence markers in ART-treated adults

Publication date :

23 November 2022

Event name :

Belgium Research on AIDS and HIV Consortium (BREACH 2022)

Event place :

Bruxelles, Belgium

Event date :

23/11/2022

Available on ORBi :

since 31 October 2023

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