HIV reservoirs; Treatment intensification; Residual viremia
Résumé :
[en] Whether ongoing viral replication occurs in people living with HIV (PLWH) despite antiretroviral therapy (ART) and leads to low-level residual viremia is still debated. Here we report on a study, in which we intensified the ART regimen by doubling dolutegravir (DTG) dosage. We investigated the impact of this strategy on HIV blood and tissue latent reservoirs, residual viremia, immune activation, and inflammation.
