Springthorpe, B., Bailey, A., Barton, P., et al. From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. Bioorg Med Chem Lett 17 (2007), 6013–6018.
Lancellotti, P., Musumeci, L., Jacques, N., et al. Antibacterial activity of ticagrelor in conventional antiplatelet dosages against antibiotic-resistant gram-positive bacteria. JAMA Cardiol, 4, 2019, 596.
Wallentin, L., Becker, R.C., Budaj, A., et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361 (2009), 1045–1057.
Sexton, T.R., Zhang, G., Macaulay, T.E., et al. Ticagrelor reduces thromboinflammatory markers in patients with pneumonia. J Am Coll Cardiol Basic Trans Science 3 (2018), 435–449.
Ulloa, E.R., Uchiyama, S., Gillespie, R., Nizet, V., Sakoulas, G., Ticagrelor increases platelet-mediated Staphylococcus aureus killing, resulting in clearance of bacteremia. J Infect Dis 224 (2021), 1566–1569.
Vicent, L., Bruña, V., Devesa, C., et al. Ticagrelor and infection risk in patients with coronary artery disease. Cardiology 146 (2021), 698–704.
Lee, C.H., Lin, H.W., Lee, N.Y., Lin, S.H., Li, Y.H., Risk of infectious events in acute myocardial infarction patients treated with ticagrelor or clopidogrel. Eur J Intern Med 85 (2021), 121–123.
Sun, J., Uchiyama, S., Olson, J., et al. Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia. Sci Transl Med, 13, 2021.
Liesenborghs, L., Meyers, S., Vanassche, T., Verhamme, P., Coagulation: at the heart of infective endocarditis. J Thromb Haemost 18 (2020), 995–1008.
Liesenborghs, L., Meyers, S., Lox, M., et al. Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves. Eur Heart J 40 (2019), 3248–3259.
Brouns, S.L.N., Provenzale, I., Geffen, J.P., Meijden, P.E.J., Heemskerk, J.W.M., Localized endothelial-based control of platelet aggregation and coagulation under flow: a proof-of-principle vessel-on-a-chip study. J Thromb Haemost 18 (2020), 931–941.
Patil, S.B., Jackman, L.E., Francis, S.E., Judge, H.M., Nylander, S., Storey, R.F., Ticagrelor effectively and reversibly blocks murine platelet P2Y 12-Mediated thrombosis and demonstrates a requirement for sustained P2Y 12 inhibition to prevent subsequent neointima. Arterioscler Thromb Vasc Biol 30 (2010), 2385–2391.
Valliammai, A., Selvaraj, A., Muthuramalingam, P., Priya, A., Ramesh, M., Pandian, S.K., Staphyloxanthin inhibitory potential of thymol impairs antioxidant fitness, enhances neutrophil mediated killing and alters membrane fluidity of methicillin resistant Staphylococcus aureus. Biomed Pharmacother, 141, 2021, 111933.
Claes, J., Liesenborghs, L., Peetermans, M., et al. Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall. J Thromb Haemost 15 (2017), 1009–1019.
Binsker, U., Palankar, R., Wesche, J., et al. Secreted immunomodulatory proteins of Staphylococcus aureus activate platelets and induce platelet aggregation. Thromb Haemost 47 (2018), 745–757.
Surewaard, B.G.J., Thanabalasuriar, A., Zeng, Z., et al. α-Toxin induces platelet aggregation and liver injury during Staphylococcus aureus sepsis. Cell Host Microbe 24 (2018), 271–284.e3.
Vanassche, T., Kauskot, A., Verhaegen, J., et al. Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation. Thromb Haemost 107 (2012), 1107–1121.
Lupu, L., Shepshelovich, D., Banai, S., Hershkoviz, R., Isakov, O., Effect of ticagrelor on reducing the risk of gram-positive infections in patients with acute coronary syndrome. Am J Cardiol 130 (2020), 56–63.
ten Berg, J., Sibbing, D., Rocca, B., et al. Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collabor. Eur Heart J 42 (2021), 2265–2269.
Zhao, Q., Zhu, Y., Xu, Z., et al. Effect of ticagrelor plus aspirin, ticagrelor alone, or aspirin alone on saphenous vein graft patency 1 year after coronary artery bypass grafting. JAMA, 319, 2018, 1677.
Baber, U., Dangas, G., Angiolillo, D.J., et al. Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS. Eur Heart J 41 (2020), 3533–3545.
Hannachi, N., Habib, G., Camoin-Jau, L., Aspirin effect on Staphylococcus aureus—platelet interactions during infectious endocarditis. Front Med, 6, 2019.
Prasannan, N., Scully, M., Novel antiplatelet strategies targeting VWF and GPIb. Platelets 32 (2021), 42–46.
Heying, R., van de Gevel, J., Que, Y.A., Moreillon, P., Beekhuizen, H., Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. Thromb Haemost 97 (2007), 617–626.
Kwiecinski, J.M., Crosby, H.A., Valotteau, C., et al. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS–MgrA signaling cascade. PLOS Pathog, 15, 2019, e1007800.
Wang, B., Muir, T.W., Regulation of virulence in Staphylococcus aureus: molecular mechanisms and remaining puzzles. Cell Chem Biol 23 (2016), 214–224.
Xiong, Y., Van Wamel, W., Nast, C.C., Yeaman, M.R., Cheung, A.L., Bayer, A.S., Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aureus in vitro and in an experimental endocarditis model. J Infect Dis 186 (2002), 668–677.
Lee, S.O., Lee, S., Lee, J.E., et al. Dysfunctional accessory gene regulator (agr) as a prognostic factor in invasive Staphylococcus aureus infection: a systematic review and meta-analysis. Sci Rep, 10, 2020, 20697.
Jahn, K., Handtke, S., Palankar, R., et al. α-hemolysin of Staphylococcus aureus impairs thrombus formation. J Thromb Haemost 20 (2022), 1464–1475.
Hannachi, N., Ogé-Ganaye, E., Baudoin, J.P., et al. Antiplatelet agents have a distinct efficacy on platelet aggregation induced by infectious bacteria. Front Pharmacol, 11, 2020, 863.
Schwarz, C., Töre, Y., Hoesker, V., et al. Host-pathogen interactions of clinical S. aureus isolates to induce infective endocarditis. Virulence 12 (2021), 2073–2087.
Karer, M., Rager-Resch, M., Haider, T., et al. Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine. Inflamm Res 71 (2022), 497–511.
Sully, E.K., Malachowa, N., Elmore, B.O., et al. Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog, 10, 2014, e1004174.
Dickey, S.W., Cheung, G.Y.C., Otto, M., Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov 16 (2017), 457–471.