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Pirotte Bernard

Département de pharmacie > Chimie pharmaceutique

CIRM

See author's contact details
Main Referenced Co-authors
De Tullio, Pascal  (380)
Delarge, J. (240)
Lebrun, P. (199)
Masereel, B. (194)
Antoine, M. H. (103)
Main Referenced Keywords
AMD (13); AMPA (9); Animals (8); Drug Discovery (8); Metabolomics (8);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (32)
Centre Interfacultaire de Recherche du Médicament - CIRM (13)
CORD - Centre de l'Oxygène, Recherche et Développement - ULiège [BE] (3)
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE] (3)
Giga-Signal Transduction - ULiège [BE] (3)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (742)
Biochemistry, biophysics & molecular biology (37)
Chemistry (27)
Endocrinology, metabolism & nutrition (12)
Cardiovascular & respiratory systems (6)

Publications (total 808)

The most downloaded
1998 downloads
Gilissen, J., Jouret, F., Pirotte, B., & Hanson, J. (2016). Insight into SUCNR1 (GPR91) structure and function. Pharmacology and Therapeutics. doi:10.1016/j.pharmthera.2016.01.008 https://hdl.handle.net/2268/194560

The most cited

116 citations (Scopus®)

Piel, G., Pirotte, B., Delneuville, I., Neven, P., Llabres, G., Delarge, J., & Delattre, L. (April 1997). Study of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide-L-Lysine-Cyclodextrin Complexes. Journal of Pharmaceutical Sciences, 86 (4), 475-80. doi:10.1021/js960298k https://hdl.handle.net/2268/18512

Bay, Y., Egeberg Jeppesen, M., Frydenvang, K., Francotte, P., Pirotte, B., Pickering, D. S., Kristensen, A. S., & Kastrup, J. S. (2024). The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2. FEBS Letters. doi:10.1002/1873-3468.14824
Peer Reviewed verified by ORBi

Lesenfants, C., Goffin, E., Colson, T., Chaaya, N., Leroy, C., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (31 January 2024). RATIONAL DESIGN OF COUMARIN DERIVATIVES WITH A BASIC MOIETY FOR INHIBITING THE SERINE PROTEASE TMPRSS2: AN INNOVATIVE APPROACH TO COMBAT THE ENTRY OF SELECTED RESPIRATORY VIRUSES [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Pochet, L., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (31 January 2024). Advances in Targeting Kainic Acid Receptors: Developing Selective Positive Allosteric Modulators from the 1,2,4-Benzothiadiazine 1,1-Dioxide scaffold [Poster presentation]. CIRM Day 2024, Liège, Belgium.
Editorial reviewed

Bay, Y., Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, K., Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, A. S., Boesen, T., Pickering, D. S., Gajhede, M., & Kastrup, J. S. (2023). Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. FEBS Journal. doi:10.1111/febs.17046
Peer Reviewed verified by ORBi

Mvondo Mbala, J.-G., Thierry Mawete, D., Makiese, A., Kwiraviwe, L., Pangu, K., Nguimi, E., Cimanga Kanyanga, R., Pieters, L., Degotte, G., Frederich, M., Matondo, A., Van Pelt, N., Caljon, G., Pirotte, B., Mbala Mavinga, B., Bambi-Nyanguile, S.-M., & Mvondo, G. (24 December 2023). Synthesis and pharmacological evaluation of fluoro/chloro-substituted acetyl and benzoyl esters of quinine as antimalarial agents. Results in Chemistry, 7, 101284. doi:10.1016/j.rechem.2023.101284
Peer Reviewed verified by ORBi

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036
Peer Reviewed verified by ORBi

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Chaaya, N., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (08 December 2023). EXPLORING COUMARIN DERIVATIVES AS NOVEL ANTIVIRAL AGENTS TARGETING TMPRSS2: A MULTIDISCIPLINARY APPROACH FOR RESPIRATORY VIRAL DISEASE TREATMENT [Poster presentation]. MedChem 2023, Bruxelles, Belgium.
Editorial reviewed

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Garigliany, M.-M., Chavatte, P., Reboud, M., Pirotte, B., El Amri, C., & Francotte, P. (19 October 2023). Design of original serine protease inhibitors to combat viral respiratory infections: a synthetic pathway for new coumarinic compounds [Poster presentation]. 2023 SRC Scientific Day, Louvain-la-Neuve, Belgium.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (19 October 2023). Glutamate Regulation: Synthesis of Selective Positive Allosteric Modulators of the Kainic Acid Receptors belonging to 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. SRC 2023 Scientific Day, Louvain-La-Neuve, Belgium.
Editorial reviewed

Colson, T., Valembois, S., Leroy, C., Bay, Y., Pickering, D. S., Kristensen, A. S., Pirotte, B., Kastrup, J. S., & Francotte, P. (07 September 2023). Design of potentiators targeting the allosteric pocket of the kainate subtype glutamate receptors [Poster presentation]. 10th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS), Zagreb, Croatia.
Editorial reviewed

Oury, C., Meyers, S., Jacques, N., Leeten, K., Jiang, Z., MUSUMECI, L., Lox, M., Debuisson, M., Goffin, E., Pirotte, B., Delvenne, P., Nchimi Longang, A., Hubert, C., Heptia, M., Hubert, P., Kuijpers, M. J. E., Vanassche, T., Martinod, K., Verhamme, P., & Lancellotti, P. (2023). Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice. JACC: Basic to Translational Science. doi:10.1016/j.jacbts.2023.02.003
Peer Reviewed verified by ORBi

Goffin, E., Fraikin, P., Abboud, D., De Tullio, P., Beaufour, C., Botez, I., Hanson, J., Danober, L., Francotte, P., & Pirotte, B. (15 March 2023). New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European Journal of Medicinal Chemistry, 250, 115221. doi:10.1016/j.ejmech.2023.115221
Peer Reviewed verified by ORBi

Arslan, D., Schoumacher, M., Dilly, S., Elmoualij, B., Zorzi, D., Quatresooz, P., Lambert, V., Noël, A., Pirotte, B., & De Tullio, P. (2023). Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors. Medicinal Chemistry, 19 (3), 276-296. doi:10.2174/1573406418666220819102627
Peer Reviewed verified by ORBi

Pirotte, B., Francotte, P., El Amri, C., Reboud-Ravaux, M., Chaaya, N., & Lesenfants, C. (2023). Substituted aryl esters of coumarin-3-carboxylic acid and their use as transmembrane serine protease 2 inhibitors and pharmaceutical composition.

Degotte, G., Pendeville-Samain, H., Di Chio, C., Ettari, R., Pirotte, B., Frederich, M., & Francotte, P. (2023). Dimeric polyphenols to pave the way for new antimalarial drugs. RSC Medicinal Chemistry. doi:10.1039/d2md00392a
Peer reviewed

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (April 2022). Deciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion [Poster presentation]. Keystone Symposia Conference, GPCRs: An Odyssey from Structure, Signaling and Regulation to Therapeutics, Snowbird, United States.

Mechouche, N., Bouhedja, M., Habila, T., Stiti, M. Z., Faury, G., Pirotte, B., & Khelili, S. (March 2022). Synthesis and evaluation of the pharmacological activity of open analogues of cromakalim carrying urea and thiourea moieties. International Journal of Research in Pharmacy and Chemistry, 12, 6-24. doi:10.33289/ijrpc.12.1.2022.12(4)
Peer reviewed

Colson, T., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (02 February 2022). Design and synthesis of key intermediates giving access to potentiators for the kainate subtype glutamate receptors [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Lesenfants, C., Goffin, E., Pirotte, B., Dammicco, S., & Francotte, P. (02 February 2022). Contribution to the synthesis of positive allosteric modulators of AMPA receptors for potential use in the early diagnosis of neurodegenerative diseases [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (February 2022). Deciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion [Paper presentation]. CIRM day, Liege, Belgium.

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2022). Potential of caffeic acid derivatives as antimalarial leads. Letters in Drug Design and Discovery, 19, 823-836.
Peer Reviewed verified by ORBi

Pirotte, B., Florence, X., Goffin, E., Leleux, F., & Lebrun, P. (2022). Research Advancements on Fluorinated and Non-Fluorinated 4- Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. Medicinal chemistry (Shariqah (United Arab Emirates)), 18 (8), 884-894. doi:10.2174/1573406418666220221145500
Peer reviewed

Degotte, G., Pirotte, B., Pendeville-Samain, H., Frederich, M., & Francotte, P. (19 November 2021). Pharmacomodulation of Ellagic Acid to Identify New Antimalarial Candidates [Poster presentation]. MedChem 2021, Liège, Belgium.

Colson, T., Valembois, S., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (19 November 2021). Design of selective ligands for the kainate subtype receptors [Poster presentation]. MedChem 2021, Liège, Belgium.
Editorial reviewed

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (October 2021). Deciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion [Poster presentation]. 5th ERNEST meeting, Bari, Italy.

LANCELLOTTI, P., Oury, C., Pirotte, B., MUSUMECI, L., Jacques, N., & Goffin, E. (23 September 2021). Preparation of pyrimidine derivatives for prevention and treatment of Gram-negative bacterial infection, contamination and fouling.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (2021). Polyhydroxybenzoic acid derivatives as potential new antimalarial agents. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. doi:10.1002/ardp.202100190
Peer reviewed

Etse, K. S., Dorosz, J., Mc Lain Christensen, Thomas, J.-Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Sandholm Katrup, J., & Francotte, P. (09 July 2021). Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. ACS Chemical Neurosciences, 12 (14), 2679-2692. doi:10.1021/acschemneuro.1c00255
Peer Reviewed verified by ORBi

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (July 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Poster presentation]. 1st Transatlantic ECI GPCR symposium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (28 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Paper presentation]. One-Day FNRS Med Chem Meeting, Louvain-La-Neuve, Belgium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (26 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Poster presentation]. 3rd CIRMDay, Liège, Belgium.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (May 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. FASEB, The Growth Hormone (GH)/ Prolactin (PRL) Family in Biology & Disease Conference.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (April 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. 4th ERNEST meeting.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (April 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. Belgian Society of Physiology and Pharmacology.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (April 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Poster presentation]. American Society for Pharmacology and Experimental Therapeutics (ASPET), GPCR colloquium.

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2021). Overview of natural antiplasmodials from the last decade to inspire medicinal chemistry. Current Medicinal Chemistry. doi:10.2174/0929867328666210329112354
Peer Reviewed verified by ORBi

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (November 2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. GDR3545.

Oury, C., Pirotte, B., MUSUMECI, L., Jacques, N., Goffin, E., & LANCELLOTTI, P. (22 October 2020). New pyrimidine derivatives for prevention and treatment of gram negative bacterial infection, contamination and fouling.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (21 September 2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11. Nature Communications, 11 (1), 4752. doi:10.1038/s41467-020-18500-x
Peer Reviewed verified by ORBi

Etse, K. S., Comeron Lamela, L., Zaragoza, G., & Pirotte, B. (30 June 2020). Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 5-methyl-1,3-bis(3-nitrobenzyl)pyrimidine-2,4(1H,3H)-dione. European Journal of Chemistry, 11/2, 91-99. doi:10.5155/eurjchem.11.2.91-99.1973
Peer reviewed

Stiti, M. Z., Belghobsi, M., Habila, T., Goffin, E., De Tullio, P., Pirotte, B., Faury, G., & Khelili, S. (March 2020). Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties. Chemical Papers, 74 (3), 915 - 928. doi:10.1007/s11696-019-00925-4
Peer Reviewed verified by ORBi

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (20 February 2020). Pharmacomodulation of natural compounds: medicinal chemistry in antimalarial purposes [Poster presentation]. ChemCys 2020, Blankenberg, Belgium.

Matute Matute, A. F., Tabart, J., CHERAMY-BIEN, J.-P., Pirotte, B., Kevers, C., Auger, C., Schini-Kerth, V., Dommes, J., Defraigne, J.-O., & PINCEMAIL, J. (22 January 2020). Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to Ex-Vivo Vascular Reactivity and Potential In Vivo Projection. Antioxidants, 9 (2), 92. doi:10.3390/antiox9020092
Peer Reviewed verified by ORBi

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. 9TH GDR3545 GPCR INTERNATIONAL MEETING.

Hanke, S., Tindall, C. A., Pippel, J., Ulbricht, D., Pirotte, B., Reboud-Ravaux, M., Heiker, J. T., & Sträter, N. (2020). Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. Journal of Medicinal Chemistry, 63 (11), 5723-5733. doi:10.1021/acs.jmedchem.9b01806
Peer Reviewed verified by ORBi

Goffin, E., Jacques, N., Musumeci, L., Nchimi Longang, A., Oury, C., Lancellotti, P., & Pirotte, B. (2020). Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity. European Journal of Medicinal Chemistry, 208, 112767. doi:10.1016/j.ejmech.2020.112767
Peer Reviewed verified by ORBi

Conlon, T., John-Schuster, G., Heide, D., Pfister, D., Lehmann, M., Hu, Y., Ertuz, Z., Lopez, M., Ansari, M., Strunz, M., Mayr, C., Cimineiri, C., Costa, R., Kohlhepp, M. S., Guillot, A., Günes, G., Jeridi, A., Funk, M., Beroshvili, G., ... Yildirim, A. Ö. (2020). Inhibition of LTβR-signalling activates Wnt-induced regeneration in lung. Nature. doi:10.1038/s41586-020-2882-8
Peer Reviewed verified by ORBi

Mouithys-Mickalad, A., Ceusters, J., Charif, M., Elmoualij, B., Schoumacher, M., Plyte, S., Franck, T., Bettendorff, L., Pirotte, B., Serteyn, D., & De Tullio, P. (2020). Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chemico-Biological Interactions, 331, 109272. doi:10.1016/j.cbi.2020.109272
Peer Reviewed verified by ORBi

Degotte, G., Lempereur, D., Adubofour, Y., Pirotte, B., Frederich, M., & Francotte, P. (11 December 2019). Dimerisation of gallic acid for malaria treatment [Poster presentation]. CIRMDay, Liège, Belgium.

Arslan, D., LAMBERT, V., Noël, A., Pirotte, B., De Tullio, P., Zorzi, D. (Other coll.), & Hansen, S. (Other coll.). (11 December 2019). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase (PDK) Inhibitors [Poster presentation]. 2nd CIRM-day.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (December 2019). GPR101 orphan receptor in XLAG syndrome [Paper presentation]. CIRM day.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (22 November 2019). Total synthesis approach: development of new antimalarial compounds [Poster presentation]. MedChem 2019, Bruxelles, Belgium.

Etse, K. S., Zaragoza, G., & Pirotte, B. (30 September 2019). Crystal structure and Hirshfeld surface analysis of N-(2-(N-methylsulfamoyl)phenyl)formamide: Degradation product of 2-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide. European Journal of Chemistry, 10 (3), 189-194. doi:10.5155/eurjchem.10.3.189-194.1903
Peer reviewed

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (05 September 2019). Pharmacomodulation of ellagic acid: a total synthesis approach [Poster presentation]. EFMC Young Medicinal Chemist, Athènes, Greece.

Oury, C., LANCELLOTTI, P., & Pirotte, B. (22 August 2019). Pyrimidine derivatives for prevention and treatment of bacterial infections.

Oury, C., LANCELLOTTI, P., & Pirotte, B. (21 August 2019). Pyrimidine derivatives for prevention and treatment of bacterial infection.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (July 2019). Pharmacology of GPR101 orphan receptor [Paper presentation]. Transardennaise de l’hypophyse.

Schoumacher, M., LAMBERT, V., Hansen, S., leenders, J., govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (23 June 2019). New insight in Metabolomics based study of Age Related Macular Degeneration (AMD): Lipoprotein profile and patients follow-up [Poster presentation]. Metabolomics 2019, The Hague, Netherlands.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (May 2019). GPR101 orphan receptor in XLAG syndrome [Paper presentation]. Belgian Society of Physiology and Pharmacology.

Lancellotti, P., Musumeci, L., Jacques, N., Servais, L., Goffin, E., Pirotte, B., & Oury, C. (2019). Antibacterial Activity of Ticagrelor in Conventional Antiplatelet Dosages Against Antibiotic-Resistant Gram-Positive Bacteria. JAMA Cardiology. doi:10.1001/jamacardio.2019.1189
Peer Reviewed verified by ORBi

Degotte, G., Halleux, A., Pirotte, B., Francotte, P., & Frederich, M. (May 2019). Design of new antimalarials inspired by ellagic acid through a total synthesis approach [Poster presentation]. Phytoday, Bruxelles, Belgium.

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (01 March 2019). 2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants. MedChemComm, 10 (3), 431-438. doi:10.1039/c8md00593a
Peer Reviewed verified by ORBi

Manos-Turvey, A., Becker, G., Francotte, P., Serrano Navacerrada, M. E., Luxen, A., Pirotte, B., Plenevaux, A., & Lemaire, C. (11 February 2019). Fully Automated Synthesis and Evaluation of [ 18 F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator as PET Radiotracer. ChemMedChem, 14 (7), 788-795. doi:10.1002/cmdc.201800816
Peer Reviewed verified by ORBi

Harrouche, K., Lahouel, A., Belghobsi, M., Pirotte, B., & Khelili, S. (2019). Synthesis, characterization, and investigation of the antioxidant activity of some 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthioureas moieties. Canadian Journal of Chemistry, 97 (12), 824 - 832. doi:10.1139/cjc-2019-0194
Peer Reviewed verified by ORBi

Habila, T., Belghobsi, M., Stiti, M.-Z., Goffin, E., De Tullio, P., Faury, G., Pirotte, B., & Khelili, S. (2019). Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties. Canadian Journal of Chemistry, 97 (1), 20 - 28. doi:10.1139/cjc-2018-0239
Peer Reviewed verified by ORBi

Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K., & Kastrup, J. S. (2019). Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. ACS Medicinal Chemistry Letters, 10 (3), 243-247. doi:10.1021/acsmedchemlett.8b00369
Peer Reviewed verified by ORBi

Arslan, D., LAMBERT, V., Noël, A., Pirotte, B., De Tullio, P., Schoumacher, M. (Other coll.), Hansen, S. (Other coll.), & Elmoualij, B. (Other coll.). (19 December 2018). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase (PDK) Inhibitors [Paper presentation]. 1st CIRM DAY.

Degotte, G., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., Pirotte, B., Francotte, P., & Frederich, M. (December 2018). Preparation of ellagic acid derivatives through a total synthesis approach to improve bioavailability [Poster presentation]. 1st CIRM Day, Liège, Belgium.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (December 2018). GPR101 orphan receptor in XLAG syndrome [Paper presentation]. CIRM day.

Arslan, D., LAMBERT, V., Elmoualij, B., Noël, A., Pirotte, B., De Tullio, P., Schoumacher, M. (Other coll.), & Hansen, S. (Other coll.). (23 November 2018). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. MedChem 2018 New Avenues in Kinase Drug Discovery: a Bright Future ?.

Degotte, G., Francotte, P., Frederich, M., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., & Pirotte, B. (November 2018). Pharmacomodulation of ellagic acid, a promising antiplasmodial agent, to improve its bioavailability [Poster presentation]. 30th International Symposium on the Chemistry of Natural Products and the 10th International Conference on Biodiversity, Athens, Greece.

Abboud, D., Daly, A., Laschet, C., Pirotte, B., BECKERS, A., & Hanson, J. (05 July 2018). GPR101 orphan receptor: a novel cause of growth hormone deregulation [Paper presentation]. World Congress of Basic and Clinical Pharmacology WCP 2018- IUPHAR, Kyoto, Japan.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (July 2018). The orphan receptor GPR101 as a novel cause of growth hormone deregulation [Poster presentation]. 18th International Union of Basic and Clinical Pharmacology (IUPHAR) congress.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (24 June 2018). NMR-Based metabolomics study of Age-related Macular Degeneration (AMD): from pre-clinic model to new target discovery [Poster presentation]. Metabolomics 2017, Seattle, United States.

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S. A., Francotte, P., Hanson, J., Pochet, L., Kastrup, J., & Pirotte, B. (2018). Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.8b00250
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Goffin, E.* , Drapier, T.* , Probst Larsen, A., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., De Tullio, P., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Sandholm Kastrup, J., & Francotte, P. (2018). 7‐Phenoxy-Substituted 3,4-Dihydro‐2H‐1,2,4-benzothiadiazine 1,1- Dioxides as Positive Allosteric Modulators of α‐Amino-3-hydroxy-5- methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry, 61, 251-264. doi:10.1021/acs.jmedchem.7b01323
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* These authors have contributed equally to this work.

Courtois, A., Makrygiannis, G., CHERAMY-BIEN, J.-P., Purnelle, A., Pirotte, B., Dogné, J.-M., Hanson, J., Defraigne, J.-O., Drion, P., & SAKALIHASAN, N. (2018). Therapeutic Applications of Prostaglandins and Thromboxane A2 Inhibitors in Abdominal Aortic Aneurysms. Current Drug Targets. doi:10.2174/1389450119666171227224314
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Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (02 October 2017). New Translational Metabolomics Exploration of Age-Related Macular Degeneration: From Patients to Functional Implication of Lactate [Poster presentation]. SMMAP 2017, Paris, France.

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (14 September 2017). From Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. 31éme ournée Franco-Belge de Pharmacochimie, SPA, Belgium.

Geubelle, P., Gilissen, J., Laschet, C., Dilly, S., Huart, J., Jouret, F., Pirotte, B., & Hanson, J. (13 September 2017). Development of original ligands for SUCNR1 [Poster presentation]. International Symposium on GPCRs and G-proteins, Bonn, Königswinter, Germany.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Pirotte, B., & Francotte, P. (August 2017). Design and Synthesis of [18F]BPAM121, a PET-Probe Targeting AMPA-subtype Glutamatergic Receptors [Poster presentation]. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Vienne, Austria.

Abboud, D., Daly, A., Laschet, C., Pirotte, B., BECKERS, A., & Hanson, J. (07 July 2017). Pharmacology of GPR101 [Paper presentation]. Transardennaise de l'hypophyse, Liège, Belgium.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Francotte, P., & Pirotte, B. (July 2017). Synthesis of [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. RICT 2017, Drug Discovery and Selection, 53rd International Conference on Medicinal Chemistry, Toulouse, France.

Schnekenburger, M., Goffin, E., Lee, J.-Y., Jang, J. Y., Mazumder, A., Ji, S., Rogister, B., Bouider, N., Lefranc, F., Miklos, W., Mathieu, V., De Tullio, P., Kim, K.-W., Dicato, M., Berger, W., Han, B., Kiss, R., Pirotte, B., & Diederich, M. (08 June 2017). Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry, 60 (11), 4714-4733. doi:10.1021/acs.jmedchem.7b00533
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Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S., & Mulle, C. (June 2017). Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Molecular Pharmacology, 91, 576-585. doi:10.1124/mol.116.107599
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Manos-Turvey, A., Lemaire, C., Deverdenne, F., Luxen, A., Francotte, P., & Pirotte, B. (June 2017). [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. Royal Society of Chemistry Medicinal Chemistry Residential School, Loughborough, United Kingdom.

Dupuis, N., Laschet, C., Franssen, D., Martyna, S., Gilissen, J., Geubelle, P., Soni, A., Parent, A.-S., Pirotte, B., Chevigné, A., Twizere, J.-C., & Hanson, J. (01 June 2017). Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Molecular Pharmacology, 91 (6), 595-608. doi:10.1124/mol.116.107714
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Geubelle, P., Gilissen, J., Dilly, S., POMA, L., Dupuis, N., Laschet, C., Abboud, D., Inoue, A., Jouret, F., Pirotte, B., & Hanson, J. (May 2017). Identification and pharmacological characterization of succinate receptor agonists. British Journal of Pharmacology, 174 (9), 796-808. doi:10.1111/bph.13738
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Abboud, D., Daly, A., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., BECKERS, A., & Hanson, J. (May 2017). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. 19th European Congress of Endocrinology, Lisbon, Portugal.

Abboud, D., Daly, A., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., BECKERS, A., & Hanson, J. (April 2017). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. Belgian Society of Physiology and Pharmacology, Bruxelles, Belgium.

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (2017). Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. ChemMedChem, 12 (21), 1810-1817. doi:10.1002/cmdc.201700409
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Abboud, D., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., & Hanson, J. (November 2016). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. Fifth annual meeting of the CNRS GDR-3545, G Protein-coupled Receptors: from Physiology to Drugs (RCPG-Physio-Med), Tours, France.

Dupuis, N., Franssen, D., Laschet, C., Geubelle, P., Soni, A., Abboud, D., Twizere, J.-C., Pirotte, B., & Hanson, J. (26 September 2016). Small molecule ligands for the orphan GPR27 [Poster presentation]. GLISTEN meeting 2016 in Prague.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (27 June 2016). New Insight into exudative Age-related Macular Degeneration (AMD): A Metabolomics Approach [Poster presentation]. Metabolomics 2016, Dublin, Ireland.

Krintel, C.* , Francotte, P.* , Pickering, D. S., Juknaite, L., Pøhlsgaard, J., Olsen, L., Frydenvang, K., Goffin, E., Pirotte, B., & Kastrup, J. (07 June 2016). Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophysical Journal, 110, 2397-2406. doi:10.1016/j.bpj.2016.04.032
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* These authors have contributed equally to this work.

Geubelle, P., Gilissen, J., Dilly, S., Jouret, F., Pirotte, B., & Hanson, J. (26 May 2016). Development of original ligands for SUCNR1 [Poster presentation]. 30èmes JFB de Pharmacochimie, Amboise, France.

Drapier, T., Geubelle, P., Bouckaert, C., Goffin, E., Dilly, S., Hanson, J., Pochet, L., Kastrup, J. S., Francotte, P., & Pirotte, B. (26 May 2016). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie 25-27 May 2016 Amboise (France), Amboise, France.

Schoumacher, M., De Tullio, P., LAMBERT, V. (Other coll.), Hansen, S. (Other coll.), Leenders, J. (Other coll.), Govaerts, B. (Other coll.), Pirotte, B. (Other coll.), RAKIC, J.-M. (Other coll.), & Noël, A. (Other coll.). (May 2016). From Metabolomics to Identification of a new therapeutic approach for Age-Related Macular Degeneration (AMD) [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (May 2016). From Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Tabart, J., Shini-Kerth, V., PINCEMAIL, J., Kevers, C., Pirotte, B., Defraigne, J.-O., & Dommes, J. (22 April 2016). Effect of Ribes nigrum leaf extracts on endothelium-dependent vasorelaxation [Poster presentation]. New frontiers in oxidative stress and redox regulation - groupe de contact FNRS "Oxidative Processes and Antioxidants", Louvain-La-Neuve, Belgium.

Laschet, C., Dupuis, N., Derj, A., Gilissen, J., Geubelle, P., Soni, A., Pirotte, B., & Hanson, J. (25 January 2016). Targeted and random mutagenesis of orphan GPCRs of the SREB family [Poster presentation]. GIGA-Day.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Geubelle, P., Laschet, C., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (25 January 2016). Identification of small molecule ligands for the orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2016.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (25 January 2016). Design, synthesis and identification of ligands for SUCNR1 and GPR22 [Paper presentation]. 2016 GIGA Day - Signal transduction pathways in health and disease, Liège, Belgium.

Gilissen, J., Jouret, F., Pirotte, B., & Hanson, J. (2016). Insight into SUCNR1 (GPR91) structure and function. Pharmacology and Therapeutics. doi:10.1016/j.pharmthera.2016.01.008
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Tabart, J., Schini-Kerth, V., PINCEMAIL, J., Kevers, C., Pirotte, B., Defraigne, J.-O., & Dommes, J. (2016). The leaf extract of Ribes nigrum L. is a potent stimulator of the endothelial formation of NO in cultured endothelial cells and porcine coronary artery rings. Journal of Berry Research, 6, 277-289. doi:10.3233/JBR-160129
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Larsen, A., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B., & Kastrup, J. (2016). Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. ACS Chemical Neurosciences, 7, 378-390. doi:10.1021/acschemneuro.5b00318
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Pirotte, B., Florence, X., Goffin, E., Medeiros, M., De Tullio, P., & Lebrun, P. (2016). 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion. European Journal of Medicinal Chemistry, 121, 338-351. doi:10.1016/j.ejmech.2016.05.042
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Harrouche, K., Renard, J., Bouider, N., De Tullio, P., Goffin, E., Lebrun, P., Faury, G., Pirotte, B., & Khelili, S. (2016). Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process. European Journal of Medicinal Chemistry, 115, 352-360. doi:10.1016/j.ejmech.2016.03.028
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Frederich, M., Pirotte, B., Fillet, M., & De Tullio, P. (2016). Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine. Journal of Medicinal Chemistry, 59 (19), 8649–8666. doi:10.1021/acs.jmedchem.5b01335
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Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (12 November 2015). FROM METABOLOMICS STUDY OF AGE RELATED MACULAR DEGENERATION (AMD) TO THE DEVELOPMENT OF NEW PDK INHIBITORS [Poster presentation]. International Gazi Pharma Symposium Series, Antalya, Turkey.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2015). Design and synthesis of PET-probes targeting AMPA-subtype receptors [Poster presentation]. 29èmes Journées franco-belges de Pharmacochimie, Spa, Belgium.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (05 June 2015). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Drapier, T., Francotte, P., Pirotte, B., Goffin, E. (Other coll.), Hanson, J. (Other coll.), Dilly, S. (Other coll.), & Kastrup, J. (Other coll.). (04 June 2015). Design, synthesis and pharmacological evaluation of dimeric ligands for the benzothiadiazine dioxide allosteric binding site of the AMPA receptors [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Schoumacher, M., Arslan, D., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), Noël, A. (Other coll.), & Pirotte, B. (Other coll.). (June 2015). From Metabolic Study of Age-Related Macular Degeneration (AMD) to Development of New PDH Kinase Inhibitors [Poster presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (13 May 2015). Design and synthesis of PET-probes targeting AMPA subtype receptors [Poster presentation]. The Bioforum 2015 of BioLiège, Liège, Belgium.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (27 January 2015). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Poster presentation]. 2015 GIGA Day: Current Advances in Medical Genetics and Genomics, Liège, Belgium.

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (27 January 2015). ßarrestin coupling of the orphan GPCR GPR27 [Poster presentation]. GIGA-day 2015, Liege, Belgium.

Tan, X., Soualmia, F., Furio, L., Renard, J.-F., Kempen, I., Qin, L., Pagano, M., Pirotte, B., El Amri, C., Hovnanian, A., & Reboud-Ravaux, M. (2015). Toward the First Class of Suicide Inhibitors of Kallikreins Involved in Skin Diseases. Journal of Medicinal Chemistry, 58, 598-612. doi:10.1021/jm500988d
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Bouider, N., Fhayli, W., Ghandour, Z., Boyer, M., Harrouche, K., Florence, X., Pirotte, B., Lebrun, P., Faury, G., & Khelili, S. (2015). Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: Study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release. Bioorganic and Medicinal Chemistry, 23, 1735-1746. doi:10.1016/j.bmc.2015.02.043
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Cieckiewicz, E., Mathieu, V., Angenot, L., Gras, T., Dejaegher, B., De Tullio, P., Pirotte, B., & Frederich, M. (2015). Semisynthesis and in Vitro Photodynamic Activity Evaluations of Halogenated and Glycosylated Derivatives of Pheophorbide a. European Journal of Organic Chemistry, 2015 (27), 6061-6074. doi:10.1002/ejoc.201500387
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Gilissen, J., Geubelle, P., Dupuis, N., Laschet, C., Pirotte, B., & Hanson, J. (2015). Forskolin-free cAMP assay for Gi-coupled receptors. Biochemical Pharmacology. doi:10.1016/j.bcp.2015.09.010
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Nørholm, A.-B., Francotte, P., Goffin, E., Botez-Pop, I., Danober, L., Lestage, P., Pirotte, B., Olsen, L., & Oostenbrink, C. (24 November 2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54 (12), 3404-3416. doi:10.1021/ci500559b
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Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (21 November 2014). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Poster presentation]. MedChem 2014 New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era?, Braine-L'Alleud, Belgium.

Laschet, C., Dupuis, N., Derj, A., Gilissen, J., Geubelle, P., Soni, A., Pirotte, B., & Hanson, J. (21 November 2014). Understanding the pharmacology and signaling pathways of the orphan G protein coupled receptor GPR85/SREB2 [Poster presentation]. Annual one-day meeting on medicinal chemistry.

Francotte, P.* , Nørholm, A.-B.* , Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., De Tullio, P., Challal, S., Thomas, J.-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S., & Pirotte, B. (06 November 2014). Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. Journal of Medicinal Chemistry, 57 (22), 9539-9553. doi:10.1021/jm501268r
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* These authors have contributed equally to this work.

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (October 2014). Identifying ligands for orphan receptors: test screening of a SOSA library with a complementation assay for orphan GPCR GPR27 [Poster presentation]. third annual meeting of the GDR3545, Montpellier, France.

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (09 September 2014). AGE-RELATED MACULAR DEGENERATION (AMD): FROM METABOLOMICS APPROACH TO THE INHIBITION OF PDK AS A NEW THERAPEUTIC TARGET [Poster presentation]. XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), Lisbonne, Portugal.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (16 July 2014). Ligand-independent Identification of orphan GPCR Signaling pathways [Paper presentation]. World Congress of basic & clinical Pharmacology, Cape Town, South Africa.

LAMBERT, V., Dufour, G., Chiap, P., Evrard, B., Noël, A., Pirotte, B., & De Tullio, P. (23 June 2014). NMR in the Pharmaceutical and Biomedical areas for identification and quantification of drugs and metabolomics applications [Paper presentation]. Drug Analysis 2014, Liège, Belgium.

Deverdenne, F., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2014). Design and synthesis of high-affinity ligands of AMPA receptors and study of their Fluorine-18 radiolabeling [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (05 June 2014). LIGAND-INDEPENDENT IDENTIFICATION OF ORPHAN GPCR ARRESTIN BINDING [Poster presentation]. 23èmes Journées franco-belges de Pharmacochimie, Metz, France.

Drapier, T., Goffin, E., Hanson, J., Dilly, S., Francotte, P., Kastrup, J., & Pirotte, B. (June 2014). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (June 2014). Inhibition of PDH Kinase as a new therapeutic target for Age-related Macular Degeneration (AMD) [Poster presentation]. 28e Journées franco-belges de Pharmacochimie, Communauté de Metz Métropole, France.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (04 April 2014). Ligand-independent Identification of orphan GPR27 Signaling pathways [Poster presentation]. Physphar 2014.

DUBOIS, N., Counerotte, S., Goffin, E., Pirotte, B., & Charlier, C. (April 2014). Validation analytique d'une méthode chromatographique destinée à rechercher et à identifier les opiacés naturels ou (semi) synthétiques. Annales de Biologie Clinique, 72 (2), 197-206. doi:10.1684/abc.2014.0944
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Derj, A., Dupuis, N., Gilissen, J., Soni, A., Pirotte, B., Chevigné, A., & Hanson, J. (27 January 2014). Unraveling the signaling and dimerization properties of CXCR3 isoforms and their interplay with CXCR7 in the context of glioblastoma pathology [Poster presentation]. GIGA Day 2014, Liège, Belgium.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (14 January 2014). Development of a luciferase complementation assay for ligand screening on orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2014.

Florence, X., Desvaux, V., Goffin, E., De Tullio, P., Pirotte, B., & Lebrun, P. (2014). Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers? European Journal of Medicinal Chemistry, 80, 36-46. doi:10.1016/j.ejmech.2014.04.024
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Noerholm, A.-B., Francotte, P., Goffin, E., Botez, L., Danober, L., Lestage, P., Pirotte, B., Kastrup, J. S., Olsen, L., & Oostenbrink, C. (2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54, 3404-3416.
Peer Reviewed verified by ORBi

Renard, J.-F., Lecomte, F., Hubert, P., de Leval, X., & Pirotte, B. (2014). N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: Cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. European Journal of Medicinal Chemistry, 74, 12-22. doi:10.1016/j.ejmech.2013.12.033
Peer Reviewed verified by ORBi

Dupuis, N., Gilissen, J., Twizere, J.-C., Pirotte, B., & Hanson, J. (18 October 2013). Development of an original β-arrestin complementation assay for orphan GPCR GPR27(SREB1) ligand and signaling pathways determination [Poster presentation]. Autumn Meeting of Belgian Society of Physiology and Pharmacology.

Nørholm, A.-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B., & Kastrup, J. S. (16 October 2013). Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold. Journal of Medicinal Chemistry, 56 (21), 8736–8745. doi:10.1021/jm4012092
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Graindorge, E., Lestage, P., Danober, L., Challal, S., Rogez, N., Nosjean, O., Caignard, D.-H., Pirotte, B., & De Tullio, P. (03 October 2013). Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors. Journal of Medicinal Chemistry, 56 (20), 7838-7850. doi:10.1021/jm400676g
Peer Reviewed verified by ORBi

Bambi Nyanguile, S.-M., Hanson, J., OOMS, A., Alpan, L., Kolh, P., dogné, J.-M., & Pirotte, B. (July 2013). Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists. European Journal of Medicinal Chemistry, 65, 32-40. doi:10.1016/j.ejmech.2013.04.033
Peer Reviewed verified by ORBi

Dupuis, N., Gilissen, J., Pirotte, B., & Hanson, J. (06 June 2013). Identification of chemical probes and signaling pathways for the orphan GPCR GPR27 [Poster presentation]. 27èmes Journées franco-belges de Pharmacochimie & 21èmes Conférences européennes du GP2A, Lille, France.

Arslan, D., Dilly, S., LAMBERT, V., Hansen, S., RAKIC, J.-M., Noël, A., Govaerts, B., Pirotte, B., & De Tullio, P. (06 June 2013). Age-related Macular Degeneration (AMD): from Metabolomics approach to the inhibition of PDH Kinase as a new therapeutic target [Poster presentation]. 27e Journées franco-belges de Pharmacochimie, Lille, France.

LAMBERT, V., Hansen, S., Rousseau, R., Govaerts, B., Pirotte, B., RAKIC, J.-M., Noël, A., & De Tullio, P. (23 May 2013). Age-related Macular Degeneration Study: A Metabolomics Approach [Paper presentation]. First Belgian-Netherlands Joint Symposium on Metabolomics: Transational approaches in Metabolomics, Spa, Belgium.

Esters, V., Karangwa, C., Tits, M., Francotte, P., Pirotte, B., Servais, A.-C., Fillet, M., Crommen, J., Robbrecht, E., MINET, A., Grisar, T., Angenot, L., & Frederich, M. (March 2013). Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda. Planta Medica, 79, 334-337. doi:10.1055/s-0032-1328283
Peer Reviewed verified by ORBi

Gilissen, J., Pirotte, B., Hanson, J., & Dupuis, N. (Other coll.). (28 January 2013). Pharmacological evaluation of succinic acid receptor (SUCNR1) modulators [Poster presentation]. GIGA Day 2013.

Dupuis, N., Gilissen, J., Pirotte, B., & Hanson, J. (28 January 2013). Chemical probes and signaling pathways for the orphan GPCR GPR27 [Poster presentation]. Giga-Day 2013.

Pirotte, B., Francotte, P., Goffin, E., & De Tullio, P. (2013). AMPA receptor positive allosteric modulators: a patent review. Expert Opinion on Therapeutic Patents, 23, 615-628. doi:10.1517/13543776.2013.770840
Peer Reviewed verified by ORBi

Mouithys-Mickalad, A., Ceusters, J., Charef, M., Pirotte, B., Ballarini, M., Franck, T., Elmoualij, B., Plyte, S., Fancelli, D., Deby-Dupont, G., De Tullio, P., & Serteyn, D. (2013). Effects of diazoxide, benzothiadiazine and benzopyrane derivatives on mitochondrial proton and electron leaks of cardiomyocytes (H9C2 cell line) [Poster presentation]. 4th World Congress on Targeting Mitochondria 2013 - Berlin, Germany, Berlin, Germany.

Akika, F.-Z., Kihal, N., Habila, T., Avramova, I., Suzer, S., Pirotte, B., & Khelili, S. (2013). Synthesis and characterization of Zn(1-x)NixAl2O4 spinels as a new heterogeneous catalyst of Biginelli's reaction. Bulletin of the Korean Chemical Society, 34, 1445-1453. doi:10.5012/bkcs.2013.34.5.1445
Peer Reviewed verified by ORBi

Hanson, J., Ferreiros, N., Pirotte, B., Geisslinger, G., & Offermanns, S. (2013). Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4. Biochemical Pharmacology, 85, 1795-1802. doi:10.1016/j.bcp.2013.04.019
Peer Reviewed verified by ORBi

Constant-Urban, C., Charif, M., Goffin, E., VAN HEUGEN, J.-C., Elmoualij, B., CHIAP, P., Mouithys-Mickalad, A., Serteyn, D., Lebrun, P., Pirotte, B., & De Tullio, P. (2013). Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic and Medicinal Chemistry Letters, 23, 5878-5881. doi:10.1016/j.bmcl.2013.08.091
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Florence, X., Goffin, E., Somers, F., Boverie, S., & Lebrun, P. (2013). 1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action. Journal of Medicinal Chemistry, 56, 3247-3256. doi:10.1021/jm301743b
Peer Reviewed verified by ORBi

Bambi Nyanguile, S.-M., Mangwala Kimpende, P., Pirotte, B., & Van Meervelt, L. (2013). N-tert-butyl-N'-[5-cyano-2-(4-methylphenoxy)phenylsulfonyl]urea, a new TXA₂ receptor antagonist. Acta Crystallographica. Section C, Crystal Structure Communications, 69, 901-903. doi:10.1107/S010827011301771X
Peer Reviewed verified by ORBi

Gilissen, J., Pirotte, B., Hanson, J., & Dupuis, N. (Other coll.). (30 November 2012). Synthesis and pharmacological evaluation of succinic acid receptor (SUCNR1) small molecule modulators [Poster presentation]. MedChem 2012 - From Rapid Dissociation to Irreversible Inhibition - Optimisation of Drug-Target Residence Time.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., Botez, I., Pirotte, B., & De Tullio, P. (September 2012). Design, Synthesis and Biological Evaluation of 4-Cycloalkyl-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides Acting as AMPA Potentiators [Poster presentation]. ISMC2012, Berlin, Germany.

Bambi Nyanguile, S.-M., Hanson, J., Dogné, J.-M., & Pirotte, B. (August 2012). Development of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor antagonists [Poster presentation]. 19th EuroQSAR, VIENNE, Austria.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., De Tullio, P., & Pirotte, B. (24 May 2012). Développement d’agents cognitifs agissant par potentialisation des récepteurs AMPA : Design de nouvelles thiénothiadiazine 1,1-dioxydes [Poster presentation]. 26es Journées Franco-Belges de Pharmacochimie, Orléans, France.

Renard, J.-F., Lecomte, F., Arslan, D., Hubert, P., & Pirotte, B. (May 2012). Evaluation de l'impact au niveau pharmacocinétique de modulations structurales de N-(pyrid-4-yl)alcanesulfonamides [Poster presentation]. 26èmes Journées franco-belges de pharmacochimie, Orléans, France.

Bambi Nyanguile, S.-M., Hanson, J., Dogné, J.-M., & Pirotte, B. (May 2012). Development of original diversely substituted benzenesulfonylureas as thromboxane A2 receptor antagonists [Poster presentation]. 26 eme journées Francobelges de Pharmacochimie, Orléans, France.

Gilissen, J., Pirotte, B., & Hanson, J. (2012). Design, synthesis and structure-activity relationship study of succinic acid receptor (SUCNR1) modulators [Paper presentation]. Forum des sciences pharmaceutiques.

Hoekstra, W. J., & Pirotte, B. (2012). Tribute to a living legend [letter to the editor]. Current Medicinal Chemistry, 19, 4207.
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Khelili, S., Kihal, N., Yekhlef, M., De Tullio, P., Lebrun, P., & Pirotte, B. (2012). Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells. European Journal of Medicinal Chemistry, 54, 873-878. doi:10.1016/j.ejmech.2012.05.011
Peer Reviewed verified by ORBi

Gilissen, J., Pirotte, B., & Hanson, J. (2012). Identification by a SOSA library screening and structure-activity relationships of succinic acid receptor (SUCNR1 or GPR91) agonist [Paper presentation]. 26èmes Journées Franco-belges de Pharmacochimie.

Goffin, E., Lamoral-Theys, D., Tajeddine, N., De Tullio, P., Mondin, L., Lefranc, F., Gailly, P., ROGISTER, B., Kiss, R., & Pirotte, B. (2012). N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis. European Journal of Medicinal Chemistry, 54, 834-44. doi:10.1016/j.ejmech.2012.06.050
Peer Reviewed verified by ORBi

Gilissen, J., Pirotte, B., & Hanson, J. (2012). Pharmacological evaluation of succinic acid receptor (SUCNR1) small molecule modulators with an intracellular calcium biosensor [Poster presentation]. Giga Day.

Krintel, C., Frydenvang, K., Olsen, L., Kristensen, M., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, M., & Kastrup, J. (2012). Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochemical Journal, 441, 173-178. doi:10.1042/BJ20111221
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., Pirotte, B., Botez, I., Danober, L., & Lestage, P. (14 July 2011). Preparation of cyclopropyl thiochroman derivatives and their use as AMPA receptor modulators.

Cherdon, C., Rolin, S., Hanson, J., OOMS, A., de Leval, L., Drion, P., michiels, C., Pirotte, B., Mullier, F., SakalihasanN, N., DEFRAIGNE, J., & Dogné, J.-M. (2011). BM-573 INHIBITS THE EARLY ATHEROSCLEROTIC LESIONS IN APO-E DEFICIENT MICE BY BLOCKING TP RECEPTORS AND THROMBOXANE SYNTHASE. In Congress of the International Society of Thrombosis and Hemostasis- 57th Annual SSC Meeting.
Peer reviewed

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (May 2011). Conception, synthèse et évaluation pharmacologique de N-(pyridin-4-yl)alcanesulfonamides en tant qu'inhibiteurs de cyclooxygénases [Poster presentation]. XVèmes Journées Franco-belges de pharmacochimie, Liège, Belgium.

Servais, A.-C., Rousseau, A., Dive, G., Frederich, M., Pirotte, B., Crommen, J., & Fillet, M. (23 March 2011). Systèmes génériques pour la séparation d’énantiomères de molécules basiques et acides à l’aide de cyclodextrines en électrophorèse capillaire en milieu non aqueux [Paper presentation]. 9ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP 11), Toulouse, France.

Cherdon, C., Rolin, S., Hanson, J., OOMS, A., de Leval, L., Drion, P., Michiels, C., Pirotte, B., Masereel, B., SakalihasanN, N., DEFRAIGNE, J., & Dogné, J.-M. (2011). BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase. Prostaglandins and Other Lipid Mediators. doi:10.1016/j.prostaglandins.2011.03.001
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Boverie, S., Michaux, C., & Lebrun, P. (2011). Impact of the Nature of the Substituent at the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Their Opening Activity toward ATP-Sensitive Potassium Channels. Journal of Medicinal Chemistry, 54, 3188-3199. doi:10.1021/jm200100c
Peer Reviewed verified by ORBi

Dintilhac, G., Arslan, D., Dilly, S., Danober, L., Botez, I., Lestage, P., Pirotte, B., & De Tullio, P. (2011). New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4- benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. MedChemComm, 2, 509. doi:10.1039/c1md00069a
Peer Reviewed verified by ORBi

Florence, X., Dilly, S., De Tullio, P., Pirotte, B., & Lebrun, P. (2011). Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process. Bioorganic and Medicinal Chemistry. doi:10.1016/j.bmc.2011.05.040
Peer Reviewed verified by ORBi

Ceusters, J., Mouithys-Mickalad, A., De Tullio, P., Elmoualij, B., Plyte, S., Ballarini, M., Fancelli, D., Deby-Dupont, G., Pirotte, B., & Serteyn, D. (2011). MODULATING EFFECT OF THE RESPIRATORY RATE OF CARDIOMYOCYTES (H9C2 CELLS) AND MITOCHONDRIAL SWELLING BY DIAZOXIDE ANALOGUES: STRUCTURE–FUNCTION RELATIONSHIPS [Poster presentation]. 2nd world Congress on Targeting Mitochondria, Berlin, Germany.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2011). Development of cognitive enhancers: design of novel thienothiadiazine 1,1-dioxides acting as AMPA potentiators [Paper presentation]. Giga-day, Liège, Belgium.

Mourlevat, S., Galizzi, J. P., Guigal-Stephan, N., Courtade-Gaïani, S., Rolland-Valognes, G., Rodriguez, M., Barbet, F., Bourrier, C., Catesson, S., Chomel, A., Danober, L., Villain, N., Caignard, D. H., Pirotte, B., Lestage, P., & Lockhart, B. P. (2011). Molecular characterization of the AMPA-receptor potentiator S70340 in rat primary cortical culture: Whole-genome expression profiling. Neuroscience Research, 70, 349-360. doi:10.1016/j.neures.2011.05.004
Peer Reviewed verified by ORBi

Gilissen, J., Pirotte, B., & Hanson, J. (2011). Synthèse et évaluation pharmacologique de modulateurs du récepteur de l'acide succinique (SUCNR1) [Poster presentation]. 25e Journées franco-belges de pharmacochimie.

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (January 2011). Pyridine Derivatives of Nimesulide as New Promising Anti-inflammatory Agents [Poster presentation]. Giga Days, Liège, Belgium.

De Tullio, P., Servais, A.-C., Fillet, M., Gillotin, F., Somers, F., CHIAP, P., Lebrun, P., & Pirotte, B. (2011). Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-Isopropylamino-4H-1,2,4- benzothiadiazine 1,1-dioxides: Toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability. Journal of Medicinal Chemistry, 54, 8353-8361. doi:10.1021/jm200786z
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D.-H., De Tullio, P., & Pirotte, B. (08 September 2010). Development of cognitive enhancers acting through AMPA potentiation: design of novel thienothiadiazine 1,1-dioxides [Poster presentation]. ISMC2010, Bruxelles, Belgium.

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (21 May 2010). Nouveaux agents anti-inflammatoires en série N-(4-pyridyl)alcanesulfonamide [Paper presentation]. 24èmes JOURNEES FRANCO-BELGES DE PHARMACOCHIMIE, Woluwé-Saint-Lambert, Belgium.

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (March 2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid [Poster presentation]. 25th International Symposium on MicroScale Bioseparations (MSB 2010), Prague, Czechia.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D. H. (15 January 2010). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Pirotte, B., De Tullio, P., Nguyen, Q.-A., Somers, F., Fraikin, P., Florence, X., Wahl, P., Hansen, J. B., & Lebrun, P. (2010). Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity. Journal of Medicinal Chemistry, 53, 147-154. doi:10.1021/jm9010093
Peer Reviewed verified by ORBi

Pirotte, B., Francotte, P., Goffin, E., fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D. H., Lestage, P., & De Tullio, P. (2010). Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators. Current Medicinal Chemistry, 17, 3575-3582. doi:10.2174/092986710792927859
Peer Reviewed verified by ORBi

Hemmer, M., Kempen, I., De Tullio, P., Frankenne, F., Lambert, V., Blacher, S., Bueb, J.-L., Foidart, J.-M., Noël, A., Tschirhart, E., & Pirotte, B. (2010). New Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent. Drug Development Research, 71, 1-10. doi:10.1002/ddr.20364
Peer reviewed

Lamoral-Theys, D., Pottier, L., Kerff, F., Dufrasne, F., Proutiere, F., Wauthoz, N., Neven, P., Ingrassia, L., Antwerpen, P. V., Lefranc, F., Gelbcke, M., Pirotte, B., Kraus, J.-L., Neve, J., Kornienko, A., Kiss, R., & Dubois, J. (2010). Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli. Bioorganic and Medicinal Chemistry, 18 (11), 3823-33. doi:10.1016/j.bmc.2010.04.047
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t
Peer Reviewed verified by ORBi

Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928
Peer Reviewed verified by ORBi

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid. Journal of Chromatography. A, 1217 (51), 7949-55. doi:10.1016/j.chroma.2010.07.005
Peer Reviewed verified by ORBi

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (November 2009). Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs? [Paper presentation]. Congress of the Belgian Society of Thrombosis and Hemostasis (BSTH 2009), Liège, Belgium.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D.-H. (07 July 2009). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (June 2009). Original cromakalim analogues as KATP channel openers [Paper presentation]. 2nd International Brussels Pancreatic Islet Symposium, Bruxelles, Belgium.

Hemmer, M., Bambi Nyanguile, S.-M., De Tullio, P., Konradowski, E., Frankenne, Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2009). Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu’agents anti-cancéreux potentiels [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2009). Les canaux potassiques ATP-dépendants: nouvelles cibles potentielles pour le traitement de divers troubles métaboliques [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Renard, J.-F., Arslan, D., Garbacki, N., De Leval, X., & Pirotte, B. (May 2009). Developpement d’inhibiteurs de cyclooxygénases: les analogues pyridiniques du nimésulide [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Dintilhac, G., Florence, X., Guillotin, F., Chiap, P., Lebrun, P., Pirotte, B., & De Tullio, P. (28 April 2009). Synthèse, étude de la métabolisation et évaluation pharmacologique du 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73) et de ses métabolites [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Hemmer, M., De Tullio, P., Konradowski, E., Frankenne, F., Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (03 February 2009). Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu’agents anti-cancéreux potentiels [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (03 February 2009). Les canaux potassiques ATP-dépendants : nouvelles cibles potentielles pour le traitement de divers troubles métaboliques [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Florence, X., Sebille, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2009). New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: modulation of the 4-position. Bioorganic and Medicinal Chemistry, 17, 7723-7731. doi:10.1016/j.bmc.2009.09.041
Peer Reviewed verified by ORBi

Arrault, A., Rocchi, S., Picard, F., Maurois, P., Pirotte, B., & Vamecq, J. (2009). A short series of antidiabetic sulfonylureas exhibit multiple ligand PPARgamma-binding patterns. Biomedicine and Pharmacotherapy, 63, 56-62. doi:10.1016/j.biopha.2007.12.007
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Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2009). Original cromakalim analogues as KATP channel openers. Metabolic and Functional Research on Diabetes, 2, 19-44 (A16.
Peer reviewed

Bissonnette, E. Y., Tremblay, G. M., Turmel, V., Pirotte, B., & Reboud-Ravaux, M. (2009). Coumarinic derivatives show anti-inflamatory effects on alveolor macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo. International Immunopharmacology, 9, 49-54. doi:10.1016/j.intimp.2008.09.009
Peer Reviewed verified by ORBi

Renard, J.-F., Arslan, D., Garbacki, N., Pirotte, B., & de Leval, X. (2009). Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. Journal of Medicinal Chemistry, 52, 5864-5871. doi:10.1021/jm900702b
Peer Reviewed verified by ORBi

Robert, S., Ghiotto, J., Pirotte, B., David, J.-L., Masereel, B., Pochet, L., & Dogné, J.-M. (2009). Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ? Pharmacological Research, 59, 160-166. doi:10.1016/j.phrs.2008.12.003
Peer Reviewed verified by ORBi

Kempen, I., Hemmer, M., Counerotte, S., Pochet, L., De Tullio, P., Foidart, J.-M., Blacher, S., Noël, A., Frankenne, F., & Pirotte, B. (December 2008). 6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis. European Journal of Medicinal Chemistry, 43 (12), 2735-50. doi:10.1016/j.ejmech.2008.01.024
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Lambert, V., Frederich, M., Rousseau, R., Detry, B., Peulen, O., Rakic, J.-M., Noël, A., Pirotte, B., Govaert, B., & De Tullio, P. (August 2008). 1H NMR metabolomic approach of the laser-induced choroidal neovascularization in mice [Poster presentation]. 20th International Symposium on Medicinal Chemistry, Vienne, Austria.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (17 May 2008). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Francotte, P., De Tullio, P., Fraikin, P., Goffin, E., Dintilhac, G., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D. H., & Pirotte, B. (May 2008). Development of cognitive enhancers acting through AMPA potentiation: design of novel benzothiadiazine 1,1-dioxides with improved pharmacokinetic profile [Paper presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2008). 6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Renard, J.-F., Arslan, D., Garbacki, N., De Leval, X., & Pirotte, B. (May 2008). (N-pyridinyl)alkanesulfonamides as potent anti-inflammatory drugs [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Hemmer, M., Kempen, I., De Tullio, P., Haan, , Lambert, V., Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2008). New biological investigations on the anti-angiogenic agent 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate: in search of its original mechanism of action [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Lebrun, P., Becker, B., Morel, N., Ghisdal, P., Antoine, M.-H., De Tullio, P., & Pirotte, B. (2008). KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides. Biochemical Pharmacology, 75, 468-475. doi:10.1016/j.bcp.2007.08.032
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Renard, J.-F., Garbacki, N., de Leval, X., & Pirotte, B. (2008). New pyridinic analogues of nimesulide as potent COXs inhibitors [Poster presentation]. XXth International Symposium on Medicinal Chemistry (EFMC – ISMC 2008), Vienne, Austria.

Sebille, S., De Tullio, P., Florence, X., Becker, B., Antoine, M.-H., Michaux, C., Wouters, J., Pirotte, B., & Lebrun, P. (2008). new R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylainothiocarbonylamino)-2H-1-benzopyrans structually related to (+/-)-cromakalim as tissue-selective pancreatic beta-celle KATP channel openers. Bioorganic and Medicinal Chemistry, 16, 5704-5719.
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., Podona, T., Diouf, O., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2008). Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. Bioorganic and Medicinal Chemistry, 16 (23), 9948-56. doi:10.1016/j.bmc.2008.10.036
Peer Reviewed verified by ORBi

Bayot, A., Basse, N., Lee, I., Gareil, M., Pirotte, B., Bulteau, A. L., Friguet, B., & Reboud-Ravaux, M. (2008). Towards the control of intercellular protein turnover: Mitochondrial Lon protease inhibitors versus proteasome inhibitors. Biochimie, 90, 260-269. doi:10.1016/j.biochi.2007.10.010
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Franck, T., Kohnen, S., Grulke, S., Neven, P., Goutman, Y., Péters, F., Pirotte, B., Deby, G., & Serteyn, D. (2008). Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity. Physiological Research, 57 (4), 577-587.
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Khelili, S., Florence, X., Bouhadja, M., Abdelaziz, S., Mechouch, N., Mohamed, Y., De Tullio, P., Lebrun, P., & Pirotte, B. (2008). Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators. Bioorganic and Medicinal Chemistry, 16, 6124-6130. doi:10.1016/j.bmc.2008.04.043
Peer Reviewed verified by ORBi

Francotte, P., Gillotin, F., Van Heuguen, J. C., Frederich, M., Lebrun, P., CHIAP, P., Pirotte, B., & De Tullio, P. (October 2007). Application of LC-SPE-NMR to the structural determination of metabolites of KATP channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Hemmer, M., De Tullio, P., Bernard, Y., Konradowski, E., Frankenne, F., Bueb, J. L., Tschirhart, E., & Pirotte, B. (October 2007). Design, synthesis and anticancer activity of novel hydroxylated coumarin derivatives [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (October 2007). Design, synthesis, and pharmacological evaluation of cromakalim analogues as pancreatic β-cell-selective KATP channel openers [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Renard, J.-F., de Leval, X., & Pirotte, B. (October 2007). Development of original pyridinic analogues of nimesulide as cycloxygenase inhibitors [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (October 2007). Thrombin activity profile: a rapid, reliable and relevant ex vivo screening test for the development of anticoagulant drugs [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (July 2007). Thrombin activity profile : a powerful ex vivo screening test for the development of anticoagulant drugs [Poster presentation]. XXIst Congress of the International Society on Thrombosis and Haemostasis, Genève, Switzerland.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (July 2007). Cromakalim analogues as pancreatic β-cell-selective KATP channel openers [Poster presentation]. 1st International Brussels Islet Symposium, Bruxelles, Belgium.

Hemmer, M., De Tullio, P., Bernard, Y., Konradowski, E., Frankenne, F., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2007). Conception, synthèse et évaluation biologique de composés coumariniques en tant qu’agents anti-cancéreux potentiels [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2007). Synthèse et évaluation biologique de nouveaux activateurs des canaux potassiques ATP-dépendants en série benzopyrane [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Renard, J.-F., Arslan, D., Garbacki, N., de Leval, X., & Pirotte, B. (May 2007). Conception, synthèse et évaluation pharmacologique in vitro et in vivo d’analogues pyridiniques du nimésulide [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Graindorge, E., Dintilhac, G., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Lesur, B., Caignard, D. H., & Pirotte, B. (May 2007). Design, synthèse et évaluation pharmacologique de 1,2,4-thiénothiadiazine 1,1-dioxydes en tant que nouveaux potentialisateurs AMPA [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Moray, A. L., Dogne, J. M., Neven, P., Ghiotto, J., Pirotte, B., & Hanson, J. (May 2007). Conception et synthèse d’outils pharmacologiques originaux pour l’étude des récepteurs au thromboxane [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (May 2007). Le profil d’activité de thrombine: un puissant test de criblage ex vivo pour le développement d’agents anticoagulants [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Kolh, P., Rolin, S., Tchana-Sato, V., Ghuysen, A., Lambermont, B., D'Orio, V., Limet, R., Pirotte, B., & Dogné, J. M. (21 April 2007). Comparative effects on LV performance, arterial hemodynamics and ventriculo-arterial coupling of two porcine models of coronary artery occlusion [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Anvers, Belgium.

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Novel dipyrazoles acting as glutamate modulators. Expert Opinion on Therapeutic Patents, 17 (12), 1489-1493. doi:10.1517/13543776.17.12.1489
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Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i
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Francotte, P., De Tullio, P., & Pirotte, B. (2007). AChE Inhibitors and their Clinical Assessment. In Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 114-144).

Pirotte, B. (2007). Laboratoire de Chimie pharmaceutique - ULg. Chimie Nouvelle, 95, 68-75.
Peer reviewed

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Cholinergic Transmission and Acetylcholine release enhancers. In Protein Misfolding in neuro degenerative Diseases : Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 96-103). Routledge.

Renard, J.-F., Arslan, D., Garbacki, N., de Leval, X., & Pirotte, B. (2007). Conception, synthèse et évaluation pharmacologique in vitro et in vivo d’analogues pyridiniques du nimésulide [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Hanson, J., Dogné, J.-M., Ghiotto, J., Moray, A.-L., Kinsella, B. T., & Pirotte, B. (2007). Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]lureas and -cyanoguanidine as selective antagonists of the TPalpha and TPBeta isoforms of the human thromboxane A2 receptor. Journal of Medicinal Chemistry, 50, 3928-3936. doi:10.1021/jm070427h
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Gillotin, F., De Tullio, P., VAN HEUGEN, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Pirotte, B., & CHIAP, P. (2007). Coupling of the LC-MS/MS and the LC-SPE-NMR for the structural identification of pancreatic KATP channel openers metabolites following in vitro biotransformation [Poster presentation]. HPLC 2007, Gent, Belgium.

Francotte, P., De Tullio, P., & Pirotte, B. (14 December 2006). Etude de la métabolisation in vitro d’activateurs des canaux potassiques appurtenant à la classe des 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: utilisation conjuguée de la LC-MS et de la LC-SPE-NMR [Paper presentation]. Forum des jeunes chercheurs du CIRM.

Hanson, J., Dogne, J. M., Ghiotto, J., Moray, A. L., Neven, P., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (18 November 2006). Pharmacological evaluation of TP receptor antagonists by differential activity on alpha and beta isoforms [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (18 November 2006). In vitro metabolisation study of several 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (18 November 2006). New developments in benzopyran derivatives as pancreatic β-cell KATP channel openers [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Frederich, M., Chiap, P., Kremers, P., Francotte, P., Lebrun, P., & Pirotte, B. (17 November 2006). Application of LC-SPE-NMR to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxide derivatives [Paper presentation]. 5th YBMRS, Bruxelles, Belgium.

Dassesse, T., de Leval, X., de Leval, L., Pirotte, B., Castronovo, V., & Waltregny, D. (November 2006). Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage. European Urology, 50 (5), 1021-31, discussion 1031. doi:10.1016/j.eururo.2006.01.036
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de Leval, X., Dassesse, T., Dogné, J.-M., Waltregny, D., Bellahcene, A., Benoit, V., Pirotte, B., & Castronovo, V. (September 2006). Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. Journal of Pharmacology and Experimental Therapeutics, 318 (3), 1057-1067. doi:10.1124/jpet.106.101188
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Hanson, J., Dogne, J. M., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (August 2006). Development of a fluorescent microplate cell based assay for the rapid evaluation of human thromboxane A2 receptor modulators acting on α and β isoforms [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

De Tullio, P., Gillotin, F., Francotte, P., Van Heugen, J.-C., Frederich, M., Lebrun, P., Chiap, P., & Pirotte, B. (August 2006). Combined use of LC-SPE-NMR and LC-MS for the metabolites characterization of ATP-sensitive potassium channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2006). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Hanson, J., Ghiotto, J., Neven, P., Kelley, L. P., Kinsella, B. T., Dogne, J. M., & Pirotte, B. (July 2006). Pharmacological evaluation of TP receptor antagonists characterized by differential activity on alpha and beta isoforms. Acta Pharmacologica Sinica, 27, 21.
Peer Reviewed verified by ORBi

Renard, J.-F., De Leval, X., & Pirotte, B. (June 2006). Nouveaux développements dans le domaine des analogues pyridiniques du nimésulide présentant un pont « inter-cycle » aminé [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Francotte, P., Fraikin, P., De Tullio, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (June 2006). Design, synthèse et évaluation pharmacologique de 1,2,4-pytridothiadiazine 1,1-dioxydes en tant que nouveaux potentiateurs AMPA [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (June 2006). Application de la LC-SPE-RMN et de la LC-MS à la détermination structurale des métabolites d’activateurs des canaux KATP de la classe des 3-alkylamino-4H-arylthiadiazine 1,1-dioxydes [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Hanson, J., Dogne, J. M., Ghiotto, J., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (June 2006). Evaluation pharmacologique d'une série de composés nitrobenzéniques sur les deux isoformes du récepteur au thromboxane A2, TPα et TPβ [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Hemmer, M., Plancon, S., Bernard, Y., Bueb, J. L., Tschirhart, E., & Pirotte, B. (June 2006). Conception, synthèse et évaluation biologique de composés coumariniques en tant qu’agents anti-cancéreux et anti-angiogéniques potentiels [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (June 2006). Nouveaux développements dans le domaine des activateurs des canaux potassiques ATP-dépendants en série benzopyrane [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Hanson, J., Reynaud, D., Qiao, N., Devel, P., Moray, A.-L., Renard, J.-F., Kelley, L. P., Winum, J.-Y., Montero, J.-L., Kinsella, B. T., Pirotte, B., Pace-Asciak, C. R., & Dogné, J.-M. (June 2006). Synthesis and pharmacological evaluation of novel thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. Journal of Medicinal Chemistry, 49 (12), 3701-3709. doi:10.1021/jm060108a
Peer Reviewed verified by ORBi

Cherdon, C., Hanson, J., Pirotte, B., Dogne, J. M., & Defraigne, J.-O. (June 2006). Activité préférentielle de la 8-iso-prostaglandine F2A (8-iso-PGF2A) sur l’isoforme alpha du récepteur au thromboxane A2 [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Hanson, J., Dogne, J. M., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (17 May 2006). Development of a fluorescent microplate cell based assay for the rapid evaluation of human thromboxane A2 receptor modulators acting on α and β isoforms [Poster presentation]. 10th Bioforum, Liège, Belgium.

Gillotin, F., De Tullio, P., Van Heugen, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Chiap, P., & Pirotte, B. (17 May 2006). Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. 10th Bioforum, Liège, Belgium.

Pirotte, B., Counerotte, S., Detry, V., Frankenne, F., Foidart, J.-M., & Noël, A. (02 March 2006). Preparation of 5-(1,1'-biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-triones and their use as inhibitors of zinc metalloendopeptidases.

Khelili, S., Lebrun, P., De Tullio, P., & Pirotte, B. (2006). Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2-H-1-benzopyran-4-yl)ureas structurally related to cromakalim. Bioorganic and Medicinal Chemistry, 14, 3530-3534. doi:10.1016/j.bmc.2006.01.009
Peer Reviewed verified by ORBi

Dogné, J.-M., Hanson, J., de Leval, X., Pratico, D., Pace-Asciak, C. R., Drion, P., Pirotte, B., & Ruan, K.-H. (2006). From the design to the clinical application of thromboxane modulators [letter to the editor]. Current Pharmaceutical Design, 12 (8), 903-923. doi:10.2174/138161206776055921
Peer Reviewed verified by ORBi

De Tullio, P., Dupont, L., Francotte, P., Counerotte, S., Lebrun, P., & Pirotte, B. (2006). Three-Dimentional Quantitative Structure-Activity Relationships of ATP-Sensitive Potassium (KATP) Channel Openers Belonging to the 3-Alkylamino-4H-1,2,4-benzo- and 3-Alkylamino-4H-1,2,4-pyridothiadiazine 1,1-Dioxide Families. Journal of Medicinal Chemistry, 49, 6779-6788. doi:10.1021/jm060534w
Peer Reviewed verified by ORBi

Michaux, C., De Leval, X., Julémont, F., Dogné, J.-M., Pirotte, B., & Durant, F. (2006). Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method. European Journal of Medicinal Chemistry, 41, 1446-1455. doi:10.1016/j.ejmech.2006.07.017
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Renard, J.-F., Julémont, F., De Leval, X., & Pirotte, B. (2006). The use of nimesulide and its analogues in cancer chemoprevention. Anti-Cancer Agents in Medicinal Chemistry, 6, 233-237. doi:10.2174/187152006776930855
Peer Reviewed verified by ORBi

Sebille, S., Gall, D., De Tullio, P., Florence, X., Lebrun, P., & Pirotte, B. (2006). Design, Synthesis and Pharmacological Evaluation of R/S-3,4-Dihydro-2,2-Dimethyl-6-Halo-4-(Phenylaminocarbonylamino)-2H-1-Benzopyrans: Towards Tissue-Selective Pancreatic Beta-Cells KATP Channel Openers Structually Related to (+/-)-Cromakalim. Journal of Medicinal Chemistry, 49, 4690-4697. doi:10.1021/jm060161z
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., & Pirotte, B. (2006). In Search of Novel Ampa Potentiators. Recent Patents on CNS Drug Discovery, 1 (3), 239-46. doi:10.2174/157488906778773661
Peer reviewed

Francotte, P., De Tullio, P., Fraikin, P., & Pirotte, B. (2006). New trends in the design of drugs against Alzheimer disease. Frontiers in Medicinal Chemistry, 3, 249-284.
Peer reviewed

De Tullio, P., Lebrun, P., Florence, X., Antoine, M. H., Francotte, P., & Pirotte, B. (2006). Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disorders. Drugs of the Future, 31, 991-1001. doi:10.1358/dof.2006.031.11.1036837
Peer reviewed

Sebille, S., Pirotte, B., Boverie, S., De Tullio, P., Lebrun, P., & Antoine, M. H. (18 August 2005). Benzopyran derivatives, method of production and use thereof.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D.-H., & Renard, P. (27 July 2005). Preparation of fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D. H., & Renard, P. (27 July 2005). Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (May 2005). Modulateurs allostériques positifs des récepteurs AMPA de la classe des 1,2,4-benzothiadiazine 1,1-dioxydes : conception, synthèse et évaluation pharmacologique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Kempen, I., Lambert, V., Melen, L., Noël, A., Foidart, J.-M., & Pirotte, B. (May 2005). Evaluation pharmacologique du 6-acétoxyméthyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle en tant qu’agent anti-angiogénique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Khelili, S., Bouider, N., Delarge, J., & Pirotte, B. (May 2005). Synthesis and pharmacological effects of opened analogues of benzothiadiazine 1,1-dioxides with sulfonylurea moieties on diuresis and glycemia [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, liège, Belgium.

Florence, X., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2005). Synthèse et évaluation biologique d’analogues 6,7-disubstitués du (R)-3-[2-(1-hydroxypropylamino)]-4H-1,2,4-benzothiadiazine 1,1-dioxyde en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP et leurs analogues biotinylés en tant qu’outils pharmacologiques [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Khelili, S., Lebrun, P., Delarge, J., & Pirotte, B. (May 2005). Synthesis and pharmacological evaluation of ATP-sensitive potassium channel openers related to cromakalim : introduction of N-methylated and non N-methylated arylsulfonylurea moieties [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Hanson, J., Reynaud, D., Qiao, N., Renard, J.-F., Botty, D., Neven, P., Pace-Asciak, C. R., Pirotte, B., & Dogne, J. M. (May 2005). Synthèse et évaluation pharmacologique de composés nitrobenzéniques originaux présentant des affinités différentielles pour les isoformes du récepteur au thromboxane A2 [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Sebille, S., Florence, X., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2005). Vers la découverte d’activateurs sélectifs du canal KATP pancréatique, analogues du cromakalim : synthèse et évaluation pharmacologique du R/S-4-(4-chlorophénylaminothiocarbonylamino)-3,4-dihydro-2,2-diméthyl-6-fluoro-2H-1-benzopyrane [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

De Leval, X., Dassesse, T., Dogne, J. M., Castronovo, V., & Pirotte, B. (May 2005). Développement de modulateurs de la voie du thromboxane A2 en tant qu’agents anti-angiogéniques et anti-métastatiques [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Lemoine, H., Grittner, D., Kuper, J., Pirotte, B., Schonlau, J., & Weber, H. (March 2005). Die diazoxid-analoge BPDZ44 und BPDZ79 unterscheiden den zwischen verschiedenen KATP-kanälen durch unterscheidliche agonistische wirkung und nicht durch unterschiedliche bindungsaffinität [Poster presentation]. Gesellschaft für Toxikologie, Mainz, Germany.

Boverie, S., Antoine, M.-H., Somers, F., Becker, B., Sebille, S., Ouedraogo, R., Counerotte, S., Pirotte, B., Lebrun, P., & De Tullio, P. (2005). Effect on KATP channel activation properties and tissue selctivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine. Journal of Medicinal Chemistry, 48, 3492-3503. doi:10.1021/jm0311339
Peer Reviewed verified by ORBi

Dupont, L., Boverie, S., Pirotte, B., & De Tullio, P. (2005). Crystal structure of 7-chloro-3-isopropoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate, C10H13CIN2O4S H2O. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 565-566.
Peer Reviewed verified by ORBi

De Tullio, P., Boverie, S., Becker, B., Antoine, M.-H., Nguyen, Q.-A., Francotte, P., Counerotte, S., Sebille, S., Pirotte, B., & Lebrun, P. (2005). 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : effect of 6,7-distribution on potency and tissue selectivity. Journal of Medicinal Chemistry, 48, 4990-5000. doi:10.1021/jm0580050
Peer Reviewed verified by ORBi

Dogné, J.-M., Rolin, S., Petein, M., Tchana-Sato, V., Ghuysen, A., Lambermont, B., Hanson, J., Magis, D., Segers, P., Pirotte, B., Masereel, B., Drion, P., D'Orio, V., & Kolh, P. (2005). Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig. Thrombosis Research, 116 (5), 431-442. doi:10.1016/j.thromres.2005.02.006
Peer Reviewed verified by ORBi

Sebille, S., De Tullio, P., Becker, B., Antoine, M.-H., Boverie, S., Pirotte, B., & Lebrun, P. (2005). 4,6-Disubstitued 2,2-dimethylchromans structually related to the KATP channel opener cromakalim : design, synthesis, and effect on insulin release and vascular tone. Journal of Medicinal Chemistry, 48, 614-621.
Peer Reviewed verified by ORBi

Hanson, J., Rolin, S., Reynaud, D., Qiao, N., Kelley, L. P., Reid, H. M., Valentin, F., Tippins, J., Kinsella, B. T., Masereel, B., Pace-Asciak, C. R., Pirotte, B., & Dogné, J.-M. (2005). In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea]. Journal of Pharmacology and Experimental Therapeutics, 313, 293-301. doi:10.1124/jpet.104.079301
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., & De Tullio, P. (2005). Crystal structure of 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H12CIN3O2S. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 353-354.
Peer Reviewed verified by ORBi

Michaux, C., Charlier, C., Julémont, F., De Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (2005). A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide. European Journal of Medicinal Chemistry, 40, 1316-1324. doi:10.1016/j.ejmech.2005.08.003
Peer Reviewed verified by ORBi

Dupont, L., Boverie, S., De Tullio, P., & Pirotte, B. (2005). Crystal structure of 7-chloro-3-isopropylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H11CIN2O2S2. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 467-468.
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Antoine, M.-H., Sebille, S., Florence, X., & Lebrun, P. (2005). New insights into the development pf ATP-sensitive potassium channel openers. Expert Opinion on Therapeutic Patents, 15, 497-504. doi:10.1517/13543776.15.5.497
Peer Reviewed verified by ORBi

Frederick, R., Robert, S., Charlier, C., De Ruyck, J., Wouters, J., Pirotte, B., Masereel, B., & Pochet, L. (2005). 3,6-Disubstitued coumarins as mechanism-based inhibitors of thrombin and factor Xa. Journal of Medicinal Chemistry, 48, 7592-7603. doi:10.1021/jm050448g
Peer Reviewed verified by ORBi

De Tullio, P., Sebille, S., Florence, X., Lebrun, P., & Pirotte, B. (17 November 2004). Utilisation de la spectrométrie RMN dans l’identification de structure de dérivés biotinylés de modulateurs de canaux potassiques ATP-dépendants [Paper presentation]. CREMAN, Séminaire.

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., Pirotte, B., Lestage, P., Danober, L. P., Renard, P., & Caignard, D. H. (12 November 2004). Novel thiadiazine derivatives useful as AMPA receptor modulators, preparation method, and pharmaceutical compositions containing them.

Michaux, C., Julemont, F., De Leval, X., Dogne, J. M., Pirotte, B., & Durant, F. (07 October 2004). Pharmacophore generation to design new leads for selective cyclooxygenase-2 inhibition [Poster presentation]. Assemblée Générale Annuelle de la Société Royale de Chimie, Liège, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2004). Synthesis and biological evaluation of novel 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

De Tullio, P., Dupont, L., Boverie, S., Becker, B., Antoine, M. H., Sebille, S., Lebrun, P., & Pirotte, B. (August 2004). Improvement of the pharmacophoric model for an agonistic activity of arylthiadiazine dioxides on pancreatic KATP channels using the CoMSIA approach [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

Roland, I., de Leval, X., Evrard, B., Pirotte, B., Dogné, J.-M., & Delattre, L. (August 2004). Modulation of the arachidonic cascade with omega 3 fatty acids or analogues: Potential therapeutic benefits. Mini Reviews in Medicinal Chemistry, 4 (6), 659-668. doi:10.2174/1389557043403738
Peer Reviewed verified by ORBi

Boverie, S., De Tullio, P., Sebille, S., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (July 2004). Relaxant effects on the rat uterine smooth muscle of putative K+ATP channel openers [Poster presentation]. EPHAR 2004, Porto, Portugal.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Pirotte, B., & Lebrun, P. (July 2004). New analogues of the potassium channel opener cromakalim : effects on rat pancreatic B-cells and rat aorta rings [Poster presentation]. EPHAR 2004, Porto, Portugal.

Boverie, S., Antoine, M. H., De Tullio, P., Sebille, S., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (June 2004). Synthèse de nouveaux analogues benzothiadiaziniques en tant qu’activateurs potentiels des canaux KATP et leur évaluation pharmacologique in vitro sur cellules B pancréatiques, aorte et utérus de rats [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Kempen, I., Frankenne, F., Telliez, A., Pommery, N., Henichart, J. P., Foidart, J.-M., & Pirotte, B. (June 2004). Synthèse et évaluation pharmacologique in vitro de nouveaux analogues du 6-acétoxyméthyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle en tant qu’agents inhibiteurs de l’invasion cellulaire [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Hanson, J., Renard, J.-F., Neven, P., De Leval, X., Rolin, S., Pirotte, B., & Dogne, J. M. (June 2004). Synthèse et évaluation pharmacologique de nouveaux antagonistes du récepteur au thromboxane A2 dérivés du BM-573 [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Michaux, C., Julemont, F., De Leval, X., Pirotte, B., & Durant, F. (June 2004). Identification d’inhibiteurs sélectifs de la cyclooxygénase-2 (COX-2) [Paper presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Michaux, C., Julemont, F., De Leval, X., Dogne, J. M., Pirotte, B., & Durant, F. (June 2004). Identification d’un inhibiteur COX-2 sélectif », 18èmes Journées Franco-belges de Pharmacochimie [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (June 2004). Nouveaux activateurs des canaux KATP analogues du cromakalim : synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques et aortes de rats [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Julemont, F., De Leval, X., Dogne, J. M., & Pirotte, B. (June 2004). Synthèse et évaluation pharmacologique d’analogues pyridiniques du nimésulide : variation du pont « inter-cycle [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (June 2004). Prodrogues de modulateurs allostériques positifs des récepteurs AMPA apparentés à l’IDRA-21 : design, synthèse, étude de la stabilité et évaluation pharmacologique [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

De Leval, X., Dassesse, T., Benoit, V., Hanson, J., Dogne, J. M., Castronovo, V., & Pirotte, B. (May 2004). Development of thromboxane A2 modulators as promising anti-metastatic and anti-angiogenic compounds [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (May 2004). New analogues of the potassium channel opener cromakalim: effects on rat pancreatic B-cells and rat aorta rings [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Hanson, J., Rolin, S., De Leval, X., Reynaud, D., Qiao, N., Neven, P., Masereel, B., Pace-Asciak, C. R., Pirotte, B., & Dogné, J.-M. (May 2004). In vivo evaluation of antithrombotic potency of BM-613, a thromboxane A2 receptor antagonist, in a rat model of arterial thrombosis [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (May 2004). Prodrugs of AMPA potentiators structurally related to IDRA-21: design, preparation, hydrolysis study and pharmacological evaluation [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Hanson, J., De Leval, X., David, J.-L., Supuran, C., Pirotte, B., & Dogné, J.-M. (2004). Progress in the field of GPIIb/IIIa antagonists. Current Medicinal Chemistry - Cardiovascular and Hematological Agents, 2, 157-167. doi:10.2174/1568016043477224
Peer Reviewed verified by ORBi

Sebille, S., De Tullio, P., Boverie, S., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2004). Recent developments in the chemistry of potassium channel activators : the cromakalim analogues. Current Medicinal Chemistry, 11, 1213-1222. doi:10.2174/0929867043365378
Peer Reviewed verified by ORBi

Julémont, F., de Leval, X., Michaux, C., Renard, J.-F., Winum, J.-Y., Montero, J.-L., Damas, J., Dogné, J.-M., & Pirotte, B. (2004). Design, synthesis and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. Journal of Medicinal Chemistry, 47, 6749-6759. doi:10.1021/jm049480l
Peer Reviewed verified by ORBi

Kempen, I., Frankenne, F., Telliez, A., Pommery, N., Henichart, J. P., Foidart, J.-M., & Pirotte, B. (2004). Design and pharmacological evaluation of recently developed 6-substituted 3-bromophenyl 2-oxo-2H-1-benzopyran 3-carboxylate derivatives as putative inhibitors of cell invasion. Fundamental and Clinical Pharmacology, 596.
Peer Reviewed verified by ORBi

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2004). Produgs of AMPA potentiators structurally related to IDRA21 : design, preparation, hydrolysis study and pharmacological evaluation. Fundamental and Clinical Pharmacology, 595.
Peer Reviewed verified by ORBi

Michaux, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (2004). Identification of COX-2 selective inhibitor. Fundamental and Clinical Pharmacology, 598.
Peer Reviewed verified by ORBi

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogné, J.-M. (2004). Characterization of preferential activity on platelet thromboxane A2 receptors of BM-613, a new thromboxane A2 antagonist. Fundamental and Clinical Pharmacology, 269.
Peer Reviewed verified by ORBi

Francotte, P., Graindorge, E., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the design of drugs against Alzheimer's disease. Current Medicinal Chemistry, 11 (13), 1757-1778. doi:10.2174/0929867043364946
Peer Reviewed verified by ORBi

De leval, X., Julémont, F., Benoit, V., Frederich, M., Pirotte, B., & Dogné, J.-M. (2004). First and second generations of COX-2 selective inhibitors. Mini Reviews in Medicinal Chemistry, 4, 597-601. doi:10.2174/1389557043403693
Peer Reviewed verified by ORBi

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (2004). New analogues of the KATP channel opener cromakalim : synthesis and pharmacological evaluation on rat pancreatic B-cells and rat aorta rings. Fundamental and Clinical Pharmacology, 599.
Peer Reviewed verified by ORBi

Kempen, I., Counerotte, S., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (2004). Effects of recently developed 6-substituted 3-bromophenyl 2-oxo-2H-1-benzopyran-3-carboxylate derivatives on HT1080 cell invasion in vitro. Fundamental and Clinical Pharmacology, 271.
Peer Reviewed verified by ORBi

Dogné, J.-M., Hanson, J., De leval, X., Kolh, P., Tchana-Sato, V., de Leval, L., Rolin, S., Ghuysen, A., Segers, P., Lambermont, B., Masereel, B., & Pirotte, B. (2004). Pharmacological characterization of N-tert-butyl-N’-[2-(4’-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time. Journal of Pharmacology and Experimental Therapeutics, 309 (2), 498-505. doi:10.1124/jpet.103.063610
Peer Reviewed verified by ORBi

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the development of positive allosteric modulators of AMPA receptors. Current Medicinal Chemistry - Central Nervous System Agents, 4, 95-103.
Peer Reviewed verified by ORBi

Mouithys-Mickalad, A., Deby, G., Dogné, J.-M., de Leval, X., Kohnen, S., Navet, R., Sluse, F., Hoebeke, M., Pirotte, B., & Lamy, M. (2004). Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1). Biochemical and Biophysical Research Communications, 325 (4), 1122-1130. doi:10.1016/j.bbrc.2004.10.155
Peer reviewed

Dogné, J.-M., Hanson, J., De leval, X., Masereel, B., Kolh, P., & Pirotte, B. (2004). New developments on thromboxane modulators. Mini Reviews in Medicinal Chemistry, 649-657. doi:10.2174/1389557043403684
Peer Reviewed verified by ORBi

Sebille, S., Boverie, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (2004). Effects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators. Fundamental and Clinical Pharmacology, 271.
Peer Reviewed verified by ORBi

Hanson, J., Renard, J.-F., Neven, P., De leval, X., Rolin, S., Pirotte, B., & Dogné, J.-M. (2004). Synthésis and pharmacological evaluation of original thromboxane A2 receptor antagonists derived from BM-573. Fundamental and Clinical Pharmacology, 596.
Peer Reviewed verified by ORBi

De Leval, X., Hanson, J., David, J.-L., Masereel, B., Pirotte, B., & Dogné, J.-M. (2004). New developments on thromboxane and prostacyclin modulators. Part II: prostacyclin modulators. Current Medicinal Chemistry, 11, 1243-1252. doi:10.2174/0929867043365279
Peer Reviewed verified by ORBi

Julémont, F., Dogné, J.-M., Pirotte, B., & de Leval, X. (2004). Recent development in the field of dual COX / 5-LOX inhibitors. Mini Reviews in Medicinal Chemistry, 4, 633-638. doi:10.2174/1389557043403747
Peer Reviewed verified by ORBi

Hanson, J., Kolh, P., Rolin, S., Tchana-Sato, V., De Leval, X., Petein, M., Masereel, B., Pirotte, B., Dogné, J.-M., Lambermont, B., David, J. L., & GHUYSEN, A. (2004). In vivo pharmacological evaluation of BM-573, an original thromboxane A2 receptor antagonist and thromboxane synthase inhibitor. Fundamental and Clinical Pharmacology, 270.
Peer Reviewed verified by ORBi

Dogné, J.-M., De leval, X., Hanson, J., Frederich, M., Lambermont, B., Ghuysen, A., Casini, A., Masereel, B., Ruan, K. E., Pirotte, B., & Kolh, P. (2004). New developments on thromboxane and prostacyclin modulators. Part I: thromboxane modulators. Current Medicinal Chemistry, 11, 1223-1241. doi:10.2174/0929867043365260
Peer Reviewed verified by ORBi

De Leval, X., Dassesse, T., Benoît, V., Pirotte, B., Merville, M.-P., David, J. L., Castronovo, V., & Dogne, J. M. (December 2003). Pharmacological evaluation of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent [Poster presentation]. 45th ASH Annual Meeting, San Diego, United States.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogne, J. M. (December 2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors [Poster presentation]. 45th ASH Annual Meeting, san Diego, United States.

Dogne, J. M., Kolh, P., Rolin, S., Tchana-Sato, V., Hanson, J., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., De Leval, X., Masereel, B., & Pirotte, B. (December 2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effect on bleeding time [Poster presentation]. 45th ASH Annual Meeting, San Diego, United States.

Kempen, I., Counerotte, S., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (22 November 2003). Effects of recently developed 6-substituted 3-bromophenyl 2-oxo-2H-1-benzopyran-3-carboxylate derivatives on HT1080 cell invasion in vitro [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogne, J. M. (22 November 2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Sebille, S., Boverie, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (22 November 2003). Effects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

de Leval, X. J., Dassesse, T., Benoit, V., Pirotte, B., Merville, M.-P., David, J.-L., Castronovo, V., & Dogné, J.-M. (16 November 2003). Pharmacological evaluation of BM-573, a dual thromboxane A(2) receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent. Blood, 102 (11, Part 2), 72.

Hanson, J., Kolh, P., Rolin, S., Tchana-Sato, V., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., Masereel, B., Pirotte, B., & Dogne, J. M. (November 2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effects on bleeding time [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Lebrun, P., Antoine, M. H., Dabrowski, M., Bondo-Hansen, J., Pirotte, B., & De Tullio, P. (July 2003). Towards tissue-selective KATP channel openers [Poster presentation]. 3rd F.E.P.S. - European Physiological Society, Nice, France.

De Leval, X., Dogne, J. M., Pirotte, B., Scozzafava, A., Casini, A., & Supuran, C. T. (June 2003). Fluorine containing aromatic/heterocyclic sulfonamides as topical intraocular pressure lowering agents with prolonged duration of action.

Pochet, L., Rolin, S., Morel, M., Pirotte, B., Frederick, R., & Masereel, B. (May 2003). Synthèse et évaluation biologique de nouvelles coumarines en tant qu’anticoagulants potentiels [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Sebille, S., Becker, B., Boverie, S., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2003). 3,4-Dihydro-2,2-dimethylchromans structurally related to the KATP channel opener cromakalim: design, synthesis, effect on insulin release and vascular tone [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Devel, P., Masereel, B., Pirotte, B., & Dogne, J. M. (May 2003). Pharmacological evaluation of the thromboxane A2 receptor antagonist BM-613 [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Devel, P., Masereel, B., Pirotte, B., & Dogne, J. M. (May 2003). Synthesis and pharmacological evaluation of BM-613, an original thromboxane A2 antagonist [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Michaux, C., De Leval, X., Julemont, F., Pirotte, B., & Durant, F. (May 2003). Pharmacophore generation to design new leads for selective cyclooxygenase-2 (COX-2) inhibition [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Kempen, I., Counerotte, S., Frankenne, F., Foidart, J.-M., Noël, A., & Pirotte, B. (May 2003). Anti-invasive and anti-migrative properties of recently developed 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Sebille, S., Becker, B., De Tullio, P., Boverie, S., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2003). Evaluation pharmacologique et étude du mécanisme d’action de molécules structurellement apparentées au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Julemont, F., De Leval, X., Michaux, C., Pirotte, B., & Dogne, J. M. (May 2003). Synthèse et évaluation pharmacologique de N-pyridinyl-alkanesulfonamides apparentés au nimésulide [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Frederick, R., Pochet, L., Pirotte, B., & Masereel, B. (May 2003). Conception, synthèse et évaluation biologique d’amino et de guanidino-coumarines inhibiteurs potentiels de thrombine [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Julemont, F., De Leval, X., Damas, J., Michaux, C., Durant, F., Pirotte, B., & Dogne, J. M. (May 2003). Pyridinic sulfonamides as potential COX-2 inhibitors [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Delarge, J., Pirotte, B., Dogné, J. M., de Leval, X., & Julémont, F. (10 April 2003). Pyridinic sulfonamide derivatives, method of production and use thereof.

Kempen, I., Papapostolou, D., Thierry, N., Pochet, L., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (07 April 2003). 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo. British Journal of Cancer, 88 (7), 1111-1118. doi:10.1038/sj.bjc.6600856
Peer Reviewed verified by ORBi

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Nouveaux composés agissant en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA : les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes [Poster presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Préparation et évaluation pharmacologique de modulateurs allostériques positifs des récepteurs AMPA : les 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes [Poster presentation]. 10ème Journée Jeunes Chercheurs, Paris, France.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Devel, P., Masereel, B., Pirotte, B., & Dogne, J. M. (31 January 2003). Etude de la sélectivité tissulaire d’un nouvel antagoniste des récepteurs au thromboxane A2, le BM-613 [Poster presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Boverie, S., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (31 January 2003). Nouveaux analogues du cromakalim en tant qu’agents pharmacologiques potentials de la classe des activateurs des canaux KATP [Paper presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Counerotte, S., Frankenne, F., Foidart, J.-M., Noël, A., & Pirotte, B. (31 January 2003). Les esters du 6-hydroxymethyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle inhibent l’invasion des cellules de fibrosarcome humain in vitro [Poster presentation]. 10ème Journée Jeunes Chercheurs, Paris, France.

De Leval, X., Benoit, V., Delarge, J., Julémont, F., Masereel, B., Pirotte, B., Merville, M.-P., David, J. L., & Dogné, J.-M. (2003). Pharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 55-59. doi:10.1016/S0952-3278(02)00235-1
Peer Reviewed verified by ORBi

Pochet, L., Dieu, M., Frederick, R., Murray, A. M., Kempen, I., Pirotte, B., & Masereel, B. (2003). Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry. Tetrahedron, 4557-4561. doi:10.1016/S0040-4020(03)00660-4
Peer Reviewed verified by ORBi

Dupont, L., Somers, F., De Tullio, P., & Pirotte, B. (2003). 3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide. Acta Crystallographica, 1509-o1511. doi:10.1107/S1600536803020324
Peer Reviewed verified by ORBi

Julémont, F., Dogné, J.-M., Laeckmann, D., Pirotte, B., & de Leval, X. (2003). Recent developments in 5-lipoxygenase inhibitors. Expert Opinion on Therapeutic Patents, 13, 1-13. doi:10.1517/13543776.13.1.1
Peer Reviewed verified by ORBi

De Tullio, P., Becker, B., Boverie, S., Dabrowski, M., Wahl, P., Antoine, M.-H., Somers, F., Sebille, S., Ouedraogo, R., Hansen, J. B., Lebrun, P., & Pirotte, B. (2003). Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides. Journal of Medicinal Chemistry, 46, 3342-3353. doi:10.1021/jm021117w
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Hanson, J., De Leval, X., Kolh, P., Supuran, C., Pirotte, B., & Dogné, J.-M. (2003). Update on GPIIb/IIIa antagonists. Expert Opinion on Therapeutic Patents, 13, 1173-1188. doi:10.1517/13543776.13.8.1173
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De Leval, X., Dassesse, T., Benoit, V., Pirotte, B., David, J.-L., Merville, M.-P., Castronovo, V., & Dogné, J.-M. (2003). Pharmacological evaluation of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent. Blood, 72.
Peer Reviewed verified by ORBi

Dogné, J.-M., de Leval, X., Kolh, P., Sanna, V., Rolin, S., Michaux, C., Mauer, M., David, J.-L., Masereel, B., & Pirotte, B. (January 2003). Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 68 (1), 49-54. doi:10.1016/S0952-3278(02)00236-3
Peer Reviewed verified by ORBi

Dogné, J.-M., Kolh, P., Rolin, S., Tchana-Sato, V., Hanson, J., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., de Leval, L., Masereel, B., & Pirotte, B. (2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effect on bleeding time. Blood, 106.
Peer Reviewed verified by ORBi

Hanson, J., Rolin, S., De Leval, X., Neven, P., De Leval, L., Masereel, B., Pirotte, B., & Dogné, J.-M. (2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors. Blood, 813a-814.
Peer Reviewed verified by ORBi

Sebille, S., Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (15 November 2002). Synthesis and pharmacological evaluation of cromakalim analogues as potassium channel activators [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

Kempen, I., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (15 November 2002). Effects of 6-substituted 2-oxo-2H-1-benzopyran-3-carbowylic acide derivatives on cellular invasion in vitro [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

Michaux, C., Charlier, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (15 November 2002). Rationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

De Leval, X., Benoît, V., Neven, P., Benoît, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (October 2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet aggregation [Poster presentation]. 17th International Congress on Thrombosis, Bologne, Italy.

Michaux, C., Charlier, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (26 September 2002). Rationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor [Poster presentation]. Assemblée générale annuelle de la Société Royale de Chimie, Namur, Belgium.

Boverie, S., De Tullio, P., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (September 2002). Relaxant effects on the rat uterine smooth muscle of K+ATP channel openers compared to ritodrine, diltiazem and verapamil : development of new pharmacological in vitro models [Poster presentation]. XVIIth International Symposium on Medicinal Chemistry, Barcelone, Spain.

De Tullio, P., Boverie, S., Becker, B., Antoine, M. H., Sebille, S., Lebrun, P., & Pirotte, B. (September 2002). 6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers [Poster presentation]. XVIIth International Symposium on Medicinal Chemistry, Barcelone, Spain.

Cosgrove, K. E., Lee, A. T., Hussain, K., Clayton, P. E., Rahier, J., Saudubray, J. M., Aynsley-Green, A., Pirotte, B., Lebrun, P., & Dunne, M. J. (September 2002). BPDZ 154 is a novel and potent activator of ATP-sensitive potassium channels in pancreatic B-cells; implications for hyperinsulinism [Paper presentation]. European Society for Paediatric Endocrinology Meeting.

Frederick, R., Pochet, L., Pirotte, B., Doucet, C., Reboud-Ravaux, M., & Masereel, B. (31 May 2002). Design et synthèse de nouveaux dérivés coumariniques inhibiteurs de thrombine [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

De Leval, X., Benoît, V., Neven, P., Benoît, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (May 2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet aggregation [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Synthèse et évaluation biologique de 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Sebille, S., Becker, B., De Tullio, P., Boverie, S., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2002). Synthèse et évaluation pharmacologique in vitro de nouveaux analogues du cromakalim en tant qu’activateurs potentiels des canaux KATP [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Kempen, I., Counerotte, S., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (May 2002). Les esters du 6-hydroxyméthyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle en tant qu’agents inhibiteurs de l’invasion cellulaire in vitro [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Lee, A. T., Cosgrove, K. E., Barnes, P. B., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (April 2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic β-cells [Poster presentation]. 21th Joint Meeting of the British Endocrine Societies, Harrogate, United Kingdom.

Boverie, S., Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., & De Tullio, P. (02 March 2002). Development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (02 March 2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (02 March 2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Tullio, P., Boverie, S., Dewalque, D., Damas, J., Sebille, S., & Pirotte, B. (02 March 2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (02 March 2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic β-cells [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Julémont, F., de Leval, X., Neven, P., Michaux, C., Charlier, C., Pirotte, B., & Dogné, J.-M. (02 March 2002). Evaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Lee, A. T., Cosgrove, K. E., Barnes, P. B., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (March 2002). BPDZ 154: a novel activator of KATP channels in β-cells [Poster presentation]. U.K.-German Joint Physiological Society Meeting, Tuebingen, Germany.

Boverie, S., Dewalque, D., Sebille, S., Damas, J., Pirotte, B., & De Tullio, P. (25 January 2002). Action myorelâchante sur la fibre musculaire lisse utérine de nouveaux dérivés de type 4H-1,2,4-benzothiadiazine 1,1-dioxyde diversement substitués en position 3 et 7 [Paper presentation]. Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (25 January 2002). Synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques de rats, aortes de rats et utérus de rates de molécules apparentées au cromakalim en tant qu'activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Counerotte, S., Frankenne, F., Foidart, J.-M., & Pirotte, B. (25 January 2002). Synthèse et évaluation pharmacologique de dérivés de l'acide 2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu'agents inhibiteurs de l'invasion cellulaire in vitro [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Wouters, J., Huygens, M., Pochet, L., Pirotte, B., Durant, F., & Masereel, B. (2002). Structural approach of the mechanism of inhibition of -chymotrypsin by coumarins. Bioorganic and Medicinal Chemistry Letters, 12, 1109-1112. doi:10.1016/S0960-894X(02)00073-2
Peer Reviewed verified by ORBi

Cosgrove, K. E., Antoine, M.-H., Lee, A. T., Barnes, P. D., De Tullio, P., Clayton, P., McCloy, R., De Lonlay, P., Nihoul-Fekete, C., Robert, J. J., Saudubray, J.-M., Rahier, J., Lindley, K. J., Hussain, K., Aynsley-Green, A., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 Activates Adenosine 5’-Triphosphate-Sensitive Potassium Channels; In Vitro Studies Using Rodent Insulin-Secreting Cells and Islets Isolated from Patients with Hyperinsulinism. Journal of Clinical Endocrinology and Metabolism, 87, 4860-4868. doi:10.1210/jc.2002-020439
Peer Reviewed verified by ORBi

Benoit, P., De Leval, X., Pirotte, B., & Dogné, J.-M. (2002). Latest discoveries in prostaglandin receptor modulators. Expert Opinion on Therapeutic Patents, 12, 1225-1235. doi:10.1517/13543776.12.8.1225
Peer Reviewed verified by ORBi

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models. Fundamental and Clinical Pharmacology, 245.
Peer Reviewed verified by ORBi

Sebille, S., becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells. Fundamental and Clinical Pharmacology, 246.
Peer Reviewed verified by ORBi

Cosgrove, K. E., Gonzalez, A. M., Lee, A. T., Barnes, P., Hussain, K., Aynsley-Green, A., Lindley, K. J., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). In vitro recovery of ATP-sensitive potassium channels in Beta-cells from patients with hyperinsulinism in infancy; effects of low temperature and BPDZ 154. Journal of Physiology, 544, 229.
Peer Reviewed verified by ORBi

Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M.-H., Pirotte, B., Lebrun, P., & De Tullio, P. (2002). 2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? Biological Chemistry, 383, 1759-1768. doi:10.1515/BC.2002.197
Peer Reviewed verified by ORBi

Dabrowski, M., Ashcroft, F. M., Ashfield, R., Lebrun, P., Pirotte, B., Egebjerg, J., Hansen, J. B., & Wahl, P. (2002). The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener. Diabetes, 51, 1896-1906. doi:10.2337/diabetes.51.6.1896
Peer Reviewed verified by ORBi

Sebille, S., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (2002). Effects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim. Fundamental and Clinical Pharmacology, 69.
Peer Reviewed verified by ORBi

Boverie, S., Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., & De Tullio, P. (2002). development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on diferent smooth muscle preparations. Fundamental and Clinical Pharmacology, 246.
Peer Reviewed verified by ORBi

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells. Endocrine abstracts 2002, 16.
Peer reviewed

Boverie, S., Becker, B., Somers, F., Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Lebrun, P., Pirotte, B., & De Tullio, P. (2002). 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity. Fundamental and Clinical Pharmacology, 69.
Peer Reviewed verified by ORBi

Nguyen, Q. A., Antoine, M. H., Ouedraogo, R., Hermann, M., Sergooris, J., Pirotte, B., & Lebrun, P. (2002). In vitro and in vivo effects of new insulin releasing agents. Biochemical Pharmacology, 515-521. doi:10.1016/S0006-2952(01)00880-2
Peer Reviewed verified by ORBi

Erb, B., Rigo, B., Pirotte, B., & Couturier, D. (2002). Synthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene Meldrum’s acids derivatives as potential potassium channel openers. Journal of Heterocyclic Chemistry, 39, 15-28. doi:10.1002/jhet.5570390102
Peer Reviewed verified by ORBi

Dogné, J.-M., De Leval, X., Benoit, P., Rolin, S., Pirotte, B., & Masereel, B. (2002). Therapeutic potential of thromboxane inhibitors in asthma. Expert Opinion on Investigational Drugs, 275-281. doi:10.1517/13543784.11.2.275
Peer Reviewed verified by ORBi

De Leval, X., Julémont, F., Delarge, J., Sanna, V., Pirotte, B., & Dogné, J.-M. (2002). Advances in the field of COX-2 inhibition. Expert Opinion on Therapeutic Patents, 12, 969-989. doi:10.1517/13543776.12.7.969
Peer Reviewed verified by ORBi

De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogné, J.-M. (2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation. Fundamental and Clinical Pharmacology, 245.
Peer Reviewed verified by ORBi

De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J.-L., & Dogné, J.-M. (2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation. Fundamental and Clinical Pharmacology, 16, 245.
Peer Reviewed verified by ORBi

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells. Fundamental and Clinical Pharmacology, 246.
Peer Reviewed verified by ORBi

De Leval, X., Julémont, F., Delarge, J., Pirotte, B., & Dogné, J.-M. (2002). New trends in dual 5-LOX/COX inhibition. Current Medicinal Chemistry, 9, 941-962. doi:10.2174/0929867024606713
Peer Reviewed verified by ORBi

Julémont, F., de Leval, X., Michaux, C., Damas, J., Charlier, C., Durant, F., Pirotte, B., & Dogné, J.-M. (2002). Spectral and crystallographic study of pyridinic analogues of nimesulide : determination of the active form of methanesulfonamides as COX-2 selective inhibitors. Journal of Medicinal Chemistry, 45, 5182-5185. doi:10.1021/jm020920n
Peer Reviewed verified by ORBi

Julémont, F., de Leval, X., Neven, P., Michaux, C., Charlier, C., Pirotte, B., & Dogné, J.-M. (2002). Evaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors. Fundamental and Clinical Pharmacology, 246.
Peer Reviewed verified by ORBi

De Tullio, P., Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M. H., Pirotte, B., & Lebrun, P. (2002). 2-N-alkylation of 3-alkylamino-substituted 2H-benzo- and 2H-pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? Fundamental and Clinical Pharmacology, 68.
Peer Reviewed verified by ORBi

Sebille, S., Becker, B., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2002). Effects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim. Fundamental and Clinical Pharmacology, 16, 69.
Peer Reviewed verified by ORBi

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic -cells. Fundamental and Clinical Pharmacology, 245.
Peer Reviewed verified by ORBi

Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., De Tullio, P., & Boverie, S. (2002). Development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations. Fundamental and Clinical Pharmacology, 246.
Peer Reviewed verified by ORBi

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle; phrmacological in vitro models. Fundamental and Clinical Pharmacology, 245.
Peer Reviewed verified by ORBi

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154: a novel activator of KATP channels in beta-cells. Pflügers Archiv: European Journal of Physiology, 338.
Peer Reviewed verified by ORBi

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154: a novel activator of K ATP channels in Beta-cells. Pflugers Archiv für die Gesamte Physiologie des Menschen und der Tiere, 338.
Peer Reviewed verified by ORBi

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic Beta-cells. Endocrine Abstracts, 16.
Peer reviewed

Michaux, C., Charlier, C., Julémont, F., Dogné, J.-M., de Leval, X., Norberg, B., Pirotte, B., & Durant, F. (2002). N-(3-Phenoxy-4-pyridinio)methanesulfonamidate. Acta Crystallographica, 88-89. doi:10.1107/S0108270101018595
Peer Reviewed verified by ORBi

De Tullio, P., Becker, B., Ouedraogo, R., Boverie, S., Somers, F., Pirotte, B., Lebrun, P., & Antoine, M. H. (08 December 2001). 2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: Ca++ channel blockers rather than K+ATP channel openers? [Poster presentation]. Workshop on the Endocrine Pancreas, Bruxelles, Belgium.

De Leval, X., David, J. L., Neven, P., Benoit, V., Pirotte, B., Merville, M.-P., Bours, V., & Dogne, J. M. (December 2001). Effects of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, on osteogenic sarcoma cell-induced platelet aggregation [Poster presentation]. The 43rd ASH Annual Meeting, Orlando, United States.

Boverie, S., Becker, B., Somers, F., Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Lebrun, P., Pirotte, B., & De Tullio, P. (17 November 2001). 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M. H., Pirotte, B., & Lebrun, P. (17 November 2001). 2-N-alkylation of 3-alkylamino-substituted 2H-benzo- and 2H-pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (17 November 2001). Effects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Julemont, F., De Leval, X., Neven, P., Michaux, C., Pirotte, B., & Dogne, J. M. (16 November 2001). Synthesis and pharmacological evaluation of pyridinic sulfonamides related to nimesulide [Poster presentation]. One Day Symposium; Drug Discovery Strategies: from Leads to Drugs, Louvain-la-Neuve, Belgium.

de Leval, X., David, J.-L., Neven, P., Benoit, V., Pirotte, B., Merville, M.-P., Bours, V., & Dogné, J.-M. (16 November 2001). Effects of BM-573, a dual thromboxane A(2) receptor antagonist and thromboxane synthase inhibitor, on osteogenic sarcoma cell-induced platelet aggregation. Blood, 98 (11, Part 2), 43.
Peer Reviewed verified by ORBi

Kempen, I., Pochet, L., Papapostolou, D., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (16 October 2001). Effects on in vitro and in vivo cellular invasion of two 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives [Poster presentation]. Molecular Mechanisms in Cancer and Alzheimer’s disease, Bruxelles, Belgium.

Becker, B., Antoine, M. H., Nguyen, Q. A., Rigo, B., Cosgrove, K. E., Barnes, P. D., Dunne, M. J., Pirotte, B., & Lebrun, P. (September 2001). ATP-sensitive K+ channels activated by a quinolinone derivative [Poster presentation]. Annual meeting of the EASD islets study group, Glasgow, United Kingdom.

Kibirev, V. K., Lacan, F., Bourdel, F., Pochet, L., Caflish, A., Doucet, C., Masereel, B., Pirotte, B., & Reboud-Ravaux, M. (July 2001). Inhibition of thrombin by oxobenzopyran derivatives: structure-activity relationships [Poster presentation]. Congrès ISTH, Paris, France.

Pirotte, B., De Tullio, P., Boverie, S., Kempen, I., & Lestage, P. (07 June 2001). Novel benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing them.

De Tullio, P., Ouedraogo, R., Boverie, S., Antoine, M. H., Becker, B., Delarge, J., Lebrun, P., & Pirotte, B. (01 June 2001). Les 3-alkylamino-2-méthyl-2H-benzo- et pyridothiadiazine dioxydes en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (01 June 2001). Conception, synthèse et évaluation pharmacologique de composés structuralement apparentés au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

De Leval, X., Delarge, J., Neven, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (01 June 2001). Effects of thromboxane A2 receptor antagonists and COX inhibitors on osteogenic sarcome cell-induced platelet aggregation [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Julemont, F., De Leval, X., Neven, P., Devel, P., Pirotte, B., Delarge, J., Masereel, B., Michaux, C., & Dogne, J. M. (01 June 2001). Synthèse et évaluation pharmacologique d’un méthanesulfonamide pyridinique apparenté à l’acide niflumique [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Lux, C., Delarge, J., De Leval, X., Kempen, I., Pirotte, B., & Dogne, J. M. (01 June 2001). Evaluation d’inhibiteurs de cyclooxygénases et d’antagonistes du TXA2 sur la migration des cellules endothéliales in vitro [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Kempen, I., Pochet, L., Papapostolou, D., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (01 June 2001). Comparaison de l’effet de deux dérivés de l’acide 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylique sur l’inhibition de l’invasion cellulaire in vitro et in vivo [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Pochet, L., Doucet, C., Pirotte, B., Frederick, R., Delarge, J., Reboud-Ravaux, M., & Masereel, B. (01 June 2001). Synthèse et évaluation enzymatique de nouvelles coumarines en tant qu’inhibiteurs de thrombine [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (01 June 2001). Propriétés biologiques des 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués en position 3: nouveaux analogues du diazoxide [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Julémont, F., de Leval, X., Neven, P., Devel, P., Pirotte, B., Delarge, J., Masereel, B., Michaux, C., & Dogné, J. M. (24 May 2001). Synthesis and pharmacological evaluation of pyridinic methanesulfonamides as potential COX-2 inhibitors [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (May 2001). Preparation and biological properties of chemically diverse 3-substituted 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the potassium channel opener diazoxide [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Julemont, F., De Leval, X., Neven, P., Devel, P., Pirotte, B., Delarge, J., Masereel, B., Michaux, C., & Dogne, J. M. (May 2001). Synthesis and pharmacological evaluation of pyridinic methanesulfonamides as potential COX-2 inhibitors [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Sebille, S., Becker, B., Boverie, S., Antoine, M.-H., Lebrun, P., & Pirotte, B. (May 2001). Synthesis and pharmacological evaluation of 4,6-disubstituted 2,2-dimethylchromans structurally related to the KATP channel opener cromakalim [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Kempen, I., Papapostolou, D., Pochet, L., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (May 2001). Effects on cellular invasion of two synthetic coumarins [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Pochet, Doucet, C., Dieu, M., Alin, V., Pirotte, B., Reboud-Ravaux, M., & Masereel, B. (May 2001). Inhibition mechanism of serine protease by coumarin derivatives [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Kempen, I., Pochet, L., Papapostolu, D., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (21 April 2001). Effects on cellular invasion of 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives [Poster presentation]. Spring Meeting Angiogenesis, Liège, Belgium.

Pirotte, B. (2001). Les Benzo- et les Pyridothiadiazine Dioxydes en Chimie Thérapeutique: Conception, Synthèse et Evaluation Pharmacologique [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/31250

Kempen, I., Pochet, L., Papapostolu, D., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (26 January 2001). Comparaison de l’effet de deux coumarines sur l’inhibition de l’invasion cellulaire in vitro et in vivo [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Julémont, F., De Leval, X., Neven, P., Devel, P., Masereel, B., Michaux, C., Pirotte, B., Delarge, J., & Dogne, J. M. (26 January 2001). Conception, synthèse et évaluation pharmacologique d’analogues pyridiniques du Nimésulide en tant qu’inhibiteurs potentiels des cyclooxygénases [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Somers, F., De Tullio, P., Boverie, S., Nguyen, Q. A., Becker, B., Antoine, M. H., Pirotte, B., & Lebrun, P. (26 January 2001). Les 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués par un atome de chlore en tant qu’activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., Arkhammar, P., Hansen, J. B., Lebrun, P., & Pirotte, B. (26 January 2001). Synthèse et évaluation pharmacologique de composés structuralement apparentés au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Somers, F., Ouedraogo, R., Antoine, M.-H., De Tullio, P., Becker, B., Fontaine, J., Damas, J., Dupont, L., Rigo, B., Delarge, J., Lebrun, P., & Pirotte, B. (2001). Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity. Journal of Medicinal Chemistry, 44, 2575-2585. doi:10.1021/jm0004648
Peer Reviewed verified by ORBi

Dupont, L., Somers, F., Boverie, S., Pirotte, B., Tinant, B., & De Tullio, P. (2001). 7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, E57, 652-o654.
Peer Reviewed verified by ORBi

Boverie, S., Antoine, M.-H., De Tullio, P., Somers, F., Becker, B., Sebille, S., Lebrun, P., & Pirotte, B. (2001). Effect on insulin release of compounds structurally related to the potassium channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-dioxide ring. Journal of Pharmacy and Pharmacology, 53, 973-980. doi:10.1211/0022357011776216
Peer Reviewed verified by ORBi

Dupont, L., De Tullio, P., Boverie, S., & Pirotte, B. (2001). 3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, E57, 602-o603. doi:10.1107/S1600536801009904
Peer Reviewed verified by ORBi

Dupont, L., De Tullio, P., Tinant, B., & Pirotte, B. (2001). (R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide mono-hydrate. Acta Crystallographica, E57, 1050-o1051.
Peer Reviewed verified by ORBi

Becker, B., Antoine, M.-H., Nguyen, Q.-A., Rigo, B., Cosgrove, K. E., Barnes, P. D., Dunne, M. J., Pirotte, B., & Lebrun, P. (2001). Synthesis and characterisation of a quinolinonic compound activating ATP-sensitive K+ channels in endocrine and smooth muscle tissues. British Journal of Pharmacology, 134, 375-385. doi:10.1038/sj.bjp.0704266
Peer Reviewed verified by ORBi

Dupont, L., Khellili, S., Pirotte, B., Tinant, B., & De Tullio, P. (2001). Absolute configuration of N-[(R)-3-methyl-2-butyl]-(S)-2-(6-methoxy-2-naphthyl)-propionamide. Acta Crystallographica, E57, 650-o651. doi:10.1107/S1600536801010285
Peer Reviewed verified by ORBi

De Leval, X., Delarge, J., Devel, P., Neven, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., Henrotin, Y., & Dogne, J.-M. (2001). Evaluation of classical NSAIDs and COX-2 selective inhibitors on purified ovine enzymes and human whole blood. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 64, 211-216. doi:10.1054/plef.2001.0262
Peer Reviewed verified by ORBi

De Tullio, P., Boverie, S., Somers, F., Ouedraogo, J., Antoine, M. H., Becker, B., Nielsen, F. E., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (01 December 2000). Preparation and biological evaluation of new 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides, analogues of the KATP channel opener BPDZ 73 [Poster presentation]. One Day Symposium : Drug Discovery Strategies: Hit and Lead Finding, Mont-St-Guibert, Belgium.

Boverie, S., Becker, B., Somers, F., De Tullio, P., Dewalque, D., Antoine, M. H., Arkhammar, Nielsen, F. E., Hansen, J. B., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (01 December 2000). New 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides related to BPDZ 73 as putative KATP channel openers: design, synthesis and pharmacological evaluation [Poster presentation]. One Day Symposium : Drug Discovery Strategies: Hit and Lead Finding, Mont-St-Guibert, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Arkhammar, P., Hansen, J. B., Lebrun, P., & Pirotte, B. (18 November 2000). Pharmacological evaluation of 4,6-disubstituted 2,2-dimethylchromans structurally related to the KATP channel opener cromakalim [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Leuven, Belgium.

Becker, B., Antoine, M. H., Nguyen, Q. A., Rigo, B., Pirotte, B., & Lebrun, P. (18 November 2000). A quinolinone derivative activating ATP-sensitive K+ channels [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Leuven, Belgium.

Damas, J., & Pirotte, B. (18 November 2000). Heart rate decrease induced by BPDZ 259, a diazoxide analogue [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Leuven, Belgium.

De Tullio, P., Somers, F., Ouedraogo, J., Boverie, S., Antoine, M. H., Becker, B., Nielsen, F. E., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (September 2000). 7-Substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as potent KATP channel openers: synthesis and bioloigical in vitro evaluation [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

Kempen, I., Pochet, L., Papapostulu, D., Boggetto, N., Doucet, C., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (September 2000). Inhibition of cellular invasion by 3-chlorophenyl 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate [Poster presentation]. 68ème Congrès de la Société de Physiologie, Liège, Belgium.

Boverie, S., Becker, B., Somers, F., De Tullio, P., Dewalque, D., Antoine, M. H., Arkhammar, P., Nielsen, F. E., Hansen, J. B., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (September 2000). Synthesis and biological evaluation of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides as KATP channel openers structurally related to BPDZ 73 [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

Bourdel, F., Lacan, F., Doucet, C., Pochet, L., Calfish, A., Masereel, B., Pirotte, B., & Reboud-Ravaux, M. (September 2000). Oxobenzopyran derivatives as thrombin inhibitors [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

Boverie, S., Antoine, M. H., Becker, B., De Tullio, P., Somers, F., Sebille, S., Lebrun, P., & Pirotte, B. (September 2000). Effect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide [Poster presentation]. 68ème Congrès de la Société de Physiologie, Liège, Belgium.

Antoine, M. H., Arkhammar, P., Nguyen, Q. A., Bondo Hansen, J., Pirotte, B., & Lebrun, P. (September 2000). A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release [Poster presentation]. 36Th Annual Meeting of the EASD.

Reboud-Ravaux, M., Pochet, L., Doucet, C., Thierry, N., Masereel, B., Delarge, J., & Pirotte, B. (August 2000). Specific inhibitors of human leukocyte elastase [Poster presentation]. World Congress on Lung Health, Florence, Italy.

Pochet, L., Doucet, C., Dieu, M., Alin, V., Pirotte, B., Reboud-Ravaux, M., & Masereel, B. (June 2000). Activity and inhibition mechanism of coumarin-based derivatives as protease inhibitor [Poster presentation]. 27th National Medicinal Chemistry Symposium, Kansas, United States.

De Tullio, P., Boverie, S., Nguyen, Q. A., Ouedraogo, R., Somers, F., Sebille, S., Antoine, M. H., Becker, B., Nielsen, F., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (May 2000). Les 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux KATP: Influence de la stéréochimie sur l’activité pharmacologique et la sélectivité tissulaire [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Boverie, S., Antoine, M. H., De Tullio, P., Somers, F., Lebrun, P., & Pirotte, B. (May 2000). Synthèse et évaluation biologique de composés structuralement apparentés au 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73): introduction d’hétéroatomes au niveau de la chaîne latérale en position 3 du cycle benzothiadiazine 1,1-dioxyde [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Somers, F., Boverie, S., Nguyen, Q. A., Antoine, M. H., Dogne, J. M., Lebrun, P., Pirotte, B., & De Tullio, P. (May 2000). 3-Alkylamino-6,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes: synthèse et évaluation pharmacologique en tant qu’activateurs potentiels du canal potassique ATP-dépendant [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, lille, France.

Khelili, S., Nguyen, Q. A., Faury, G., Leclerc, G., Pirotte, B., & Lebrun, P. (May 2000). Etude de quelques dérivés benzothiadiaziniques apparentés au diazoxide et aux thiazides en tant qu’activateurs de canaux potassiques [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Kempen, I., Papapostolu, D., Pochet, L., Boggetto, N., Doucet, C., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (May 2000). Le 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Julemont, F., Neven, P., De Leval, X., Masereel, B., Michaux, C., Pirotte, B., Delarge, J., & Dogne, J. M. (May 2000). Conception, synthèse et évaluation pharmacologique de l’analogue pyridinique du nimésulide en tant qu’inhibiteur des cyclooxygénases [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Leval, X., Delarge, J., Devel, P., Damas, J., Henrotin, Y., Michaux, C., Pirotte, B., Masereel, B., & Dogne, J. M. (May 2000). Evaluation de la selectivité COX-1/COX-2 de drogues à visée anti-inflammatoire sur sang humain [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Boverie, S., Somers, F., Ouedraogo, R., Antoine, M. H., Dogne, J. M., De Leval, X., De Tullio, P., Pirotte, B., & Lebrun, P. (04 March 2000). 7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., & Lestage, P. (04 March 2000). New chemical and pharmacological developments in the field of positive allosteric modulators of AMPA receptors structurally related to cyclothiazide and diazoxide [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Leval, X., Delarge, J., Devel, P., Damas, J., Henrotin, Y., Neven, P., Masereel, B., Pirotte, B., Somers, F., Wouters, J., Michaux, C., & Dogne, J. M. (04 March 2000). Evaluation of classical NSAIDs in a model of human whole blood assay [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dogne, J. M., De Leval, X., Neven, P., Somers, F., Delarge, J., Rolin, S., Michaux, C., Wauters, J., Pirotte, B., Damas, J., & Masereel, B. (04 March 2000). Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Kempen, I., Pochet, L., Doucet, C., Lacan, F., Bourdel, F., Reboud-Ravaux, M., Noël, A., Foidart, J.-M., & Pirotte, B. (29 January 2000). Inhibition of cancer cells invasion by coumarin derivatives [Poster presentation]. A.B.E.C., Invasion and metastasis, Gand, Belgium.

Boverie, S., De Tullio, P., Ouedraogo, R., Nguyen, Q. A., Somers, F., Damas, J., Lebrun, P., & Pirotte, B. (28 January 2000). Les 3-alkylsulfanyl- et 3-alkoxy-4H-1,2,4-benzothiadiazine 1,1-dioxydes structuralement apparentés aux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Pochet, L., Doucet, C., Lacan, F., Bourdel, F., Masereel, B., Frankenne, F., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (28 January 2000). Les esters de l’acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’agents antiinvasifs potentiels dans le traitement du cancer [Paper presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Pochet, L., Doucet, C., Lacan, F., Bourdel, F., Masereel, F., Masereel, B., Frankenne, F., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (28 January 2000). Les esters de l’acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’agents antiinvasifs potentiels dans le traitement du cancer [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Somers, F., Boverie, S., Ouedraogo, R., Antoine, M. H., Dogne, J. M., De Leval, X., Lebrun, P., Pirotte, B., & De Tullio, P. (28 January 2000). Nouveaux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: synthèse et évaluation pharmacologique en tant qu’inhibiteurs potentiels du processus insulino-sécrétoire [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Pirotte, B., Ouedraogo, R., De Tullio, P., Khelili, S., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Damas, J., & Lebrun, P. (2000). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis and pharmacological evaluation. Journal of Medicinal Chemistry, 43, 1456-1466. doi:10.1021/jm991069o
Peer Reviewed verified by ORBi

Somers, F., De Tullio, P., Boverie, S., Dogne, J.-M., de Leval, X., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2000). Synthesis and biological effects of new 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides on insulin-secreting cells. Pharmacy and Pharmacology Communications, 6, 89-95. doi:10.1211/096089296765556980
Peer reviewed

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M.-H., Boverie, S., Fontaine, J., Damas, J., Pirotte, B., & Lebrun, P. (2000). Comparison between the effects of 3-aralkylamino-/3-cycloalkylalkylamino-substituted benzothiadiazine dioxides and their corresponding quinazolinone isosteres on different smooth muscle preparations. Fundamental and Clinical Pharmacology, 14, 171.
Peer Reviewed verified by ORBi

Erb, B., Akue, R., Rigo, B., Pirotte, B., & Couturier, D. (2000). Synthesis of 2-aminoquinazoline-4(3H)-one derivatives as potential potassium channel openers. Journal of Heterocyclic Chemistry, 37, 253-260. doi:10.1002/jhet.5570370206
Peer Reviewed verified by ORBi

Ouedraogo, R., Fontaine, J., Antoine, M.-H., Pirotte, B., & Lebrun, P. (2000). Effects of 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides on smooth muscle contractile activity. Pharmacy and Pharmacology Communications, 6, 97-100.
Peer reviewed

Pochet, L., Doucet, C., Dive, G., Wouters, J., Masereel, B., Reboud-Ravaux, M., & Pirotte, B. (2000). Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase. Bioorganic and Medicinal Chemistry, 8 (6), 1489-1501. doi:10.1016/S0968-0896(00)00071-7
Peer Reviewed verified by ORBi

De Leval, X., Henrotin, Y., Labasse, A., Reginster, J.-Y., Neven, P., Delarge, J., Somers, F., Masereel, B., Pirotte, B., & Dogne, J.-M. (2000). Comparison of the effects of nimesulide and nimesulide-L-lysine on PGE2 production by COX-1 and COX-2 and on chondrocyte metabolism in vitro. Pharmacy and Pharmacology Communications, 6, 83-87. doi:10.1211/146080800128735683
Peer reviewed

De Leval, X., Dogne, J.-M., Masereel, B., Pirotte, B., Reginster, J.-Y., Neven, P., Labasse, A., Delarge, J., & Henrotin, Y. (2000). Profile of nimesulide and nimesulide-L-lysine-β-cyclodextrin on chondrocyte metabolism. Fundamental and Clinical Pharmacology, 14, 167.
Peer Reviewed verified by ORBi

De Leval, X., Henrotin, Y., Masereel, B., Pirotte, B., Somers, F., Neven, P., Devel, P., Delarge, J., & Dogne, J.-M. (2000). Evaluation of classical NSAIDs on COX-1 and COX-2 purified enzymes and prognosis of their effects on physiological responses. Fundamental and Clinical Pharmacology, 14, 167.
Peer Reviewed verified by ORBi

De Leval, X., Dogné, J.-M., Delarge, J., Pirotte, B., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Reginster, J.-Y., & Henrotin, Y. (2000). Comparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro. Mediators of Inflammation, 9, 51.
Peer Reviewed verified by ORBi

Dogne, J.-M., De Leval, X., Delarge, J., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Somers, F., Pirotte, B., Reginster, J.-Y., & Henrotin, Y. (2000). Synthesis and evaluation of non-carboxylic pyridinic derivatives as cyclooxygenase inhibitors. Mediators of Inflammation, 9, 52.
Peer Reviewed verified by ORBi

Kempen, I., Doucet, C., Pochet, L., Lacan, F., Bourdel, F., Noël, A., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (2000). Coumarin derivatives as putative antiinvasive agents in cancer. Fundamental and Clinical Pharmacology, 14, 169.
Peer Reviewed verified by ORBi

Boverie, S., Antoine, M.-H., Becker, B., De Tullio, P., Somers, F., Sebille, S., Lebrun, P., & Pirotte, B. (2000). Effect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide. Pflügers Archiv: European Journal of Physiology, 439, 220-R221.
Peer Reviewed verified by ORBi

Kempen, I., Pochet, L., Papapostulu, D., Boggetto, N., Doucet, C., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (2000). Inhibition of cellular invasion by 3-chlorophenyl 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate. Pflügers Archiv: European Journal of Physiology, 439, 252.
Peer Reviewed verified by ORBi

Boverie, S., Somers, F., Ouedraogo, R., Antoine, M.-H., Dogne, J.-M., De Leval, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2000). 7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro. Fundamental and Clinical Pharmacology, 14, 299.
Peer Reviewed verified by ORBi

Dogne, J.-M., De Leval, X., Neven, P., Somers, F., Delarge, J., Rolin, S., Michaux, C., Wauters, J., Pirotte, B., Damas, J., & Masereel, B. (2000). Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists. Fundamental and Clinical Pharmacology, 14, 300.

Lebrun, P., Arkhammar, P., Antoine, M.-H., Nguyen, Q.-A., Bondo Hansen, J., & Pirotte, B. (2000). A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release. Diabetologia, 43, 723-732. doi:10.1007/s001250051370
Peer Reviewed verified by ORBi

Dogne, J.-M., De Leval, X., Neven, P., Rolin, S., Pirotte, B., David, J.-L., Delarge, J., & Masereel, B. (2000). Characterization of antiplatelet activity of ticlopidine and acetylsalicylic acid by PFA-100. Fundamental and Clinical Pharmacology, 14, 168.
Peer Reviewed verified by ORBi

De Leval, X., Delarge, J., Somers, F., De Tullio, P., Henrotin, Y., Pirotte, B., & Dogne, J.-M. (2000). Recent advances in inducible cyclooxygenase (COX-2) inhibition. Current Medicinal Chemistry, 7 (10), 1041-1062. doi:10.2174/0929867003374417
Peer Reviewed verified by ORBi

De Tullio, P., Delarge, J., & Pirotte, B. (2000). Therapeutic and chemical developments of cholecystokinin receptor ligands. Expert Opinion on Investigational Drugs, 9, 129-146. doi:10.1517/13543784.9.1.129
Peer reviewed

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M. H., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l’Alleud, Belgium.

Somers, F., De Tullio, P., Ouedraogo, R., Antoine, M. H., Boverie, S., Fontaine, J., Damas, J., Lebrun, P., & Pirotte, B. (26 November 1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides and 2-alkylamino 3H-quinazolin-4-ones as putative KATP channel openers: influence of stereochemistry on biological activity [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

Boverie, S., De Tullio, P., Ouedraogo, R., Nguyen, Q. A., Somers, F., Damas, J., Lebrun, P., & Pirotte, B. (20 November 1999). 3-Alkylsulfanyl- and 3-alkoxy-substituted benzothiadiazines structurally related to 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Kempen, I., Doucet, C., Pochet, L., Lacan, F., Bourdel, F., Noël, A., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (20 November 1999). Coumarin derivatives as putative antiinvasive agents in cancer [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M. H., Boverie, S., Fontaine, J., Damas, J., Pirotte, B., & Lebrun, P. (20 November 1999). Comparison between the effects of 3-aralkylamino-/3-cycloalkylalkylamino-substituted benzothiadiazine dioxides and their corresponding quinazolinone isosteres on different smooth muscle preparations [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Leval, X., Dogne, J. M., Masereel, B., Pirotte, B., Reginster, J.-Y., Neven, P., Labasse, A., Delarge, J., & Henrotin, Y. (20 November 1999). Profile of nimesulide and nimesulide-L-lysine-β-cyclodextrin on chondrocyte metabolism [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Leval, X., Henrotin, Y., Masereel, B., Pirotte, B., Somers, F., Neven, P., Devel, P., Delarge, J., & Dogne, J. M. (20 November 1999). Evaluation of classical NSAIDs on COX-1 and COX-2 purified enzymes and prognosis of their effects on physiological responses [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dogne, J. M., De Leval, X., Neven, P., Rolin, S., Pirotte, B., David, J. L., Delarge, J., & Masereel, B. (20 November 1999). Characterization of antiplatelet activity of ticlopidine and acetylsalicylic acid by PFA-100 [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dupont, L., De Tullio, P., Khelili, S., Somers, F., Delarge, J., & Pirotte, B. (28 October 1999). Crystal structures of R- and S-7-chloro-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide (absolute configurations) [Poster presentation]. First Belgian Crystallography Symposium, Bruxelles, Belgium.

De Leval, X., Dogne, J. M., Delarge, J., Pirotte, B., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Reginster, J.-Y., & Henrotin, Y. (17 September 1999). Comparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro [Poster presentation]. Groupe de Contact FNRS/FRSM “Mécanismes Cellulaires de l’Inflammation", Bruxelles, Belgium.

Dogne, J. M., De Leval, X., Delarge, J., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Somers, F., Pirotte, B., Reginster, J.-Y., & Henrotin, Y. (17 September 1999). Synthesis and evaluation of non-carboxylic pyridinic derivatives as cyclooxygenase inhibitors [Poster presentation]. Groupe de Contact FNRS/FRSM “Mécanismes Cellulaires de l’Inflammation", Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Morain, P., Lestage, P., & Lebrun, P. (July 1999). Pyrido- and benzothiadiazine dioxides related to diazoxide: structural requirements leading to a KATP channel activator or to an allosteric modulator of the AMPA receptors [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

Lebrun, P., Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Dunne, M. J., Pirotte, B., & Masereel, B. (July 1999). In vivo et in vitro effect of new glibenclamide isosteres [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

Lebrun, P., Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Dunne, M. J., Pirotte, B., & Masereel, B. (July 1999). In vivo et in vitro effect of new glibenclamide isosteres [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

De Tullio, P., Nielsen, F. E., Hansen, J. B., Hansen, H. C., Pirotte, B., Boverie, S., Somers, F., Lebrun, P., & Mogensen, J. P. (01 July 1999). 1,2,4-Benzothiadiazine derivatives, their preparation and use.

De Tullio, P., Boverie, S., Somers, F., Lebrun, P., Pirotte, B., Nielsen, F., & Hansen, J. B. (01 July 1999). Pyrido 1,2,4-thiadiazine derivatives, their preparation and use.

Somers, F., De Tullio, P., Boverie, S., Dogne, J. M., Antoine, M. H., Lebrun, P., & Pirotte, B. (12 June 1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Boverie, S., Nguyen, Q. A., De Tullio, P., Somers, F., Pirotte, B., & Lebrun, P. (12 June 1999). Pharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Dogne, J. M., Neven, P., Rolin, S., De Leval, X., Somers, F., David, J. L., Delarge, J., De Tullio, P., Pirotte, B., & Masereel, B. (May 1999). Impact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Ouedraogo, R., Fontaine, J., Antoine, M. H., Pirotte, B., & Lebrun, P. (May 1999). Synthèse et évaluation pharmacologique de 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

De Leval, X., Dogne, J. M., Neven, P., Labasse, A., Masreel, B., Somers, F., Pirotte, B., De Tullio, P., Delarge, J., Reginster, J.-Y., & Henrotin, Y. (May 1999). Evaluation de la sélectivité COX-1 vs COX-2 de drogues à potentialités anti-inflammatoires [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Pochet, L., Dive, G., Alin, V., Pirotte, B., Doucet, C., Delarge, J., Reboud-Ravaux, M., & Masereel, B. (May 1999). Mécanisme d’inactivation de l’α-chymotrypsine par les dérivés coumariniques: étude de l’ouverture de la lactone [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Somers, F., De Tullio, P., Boverie, S., Dogne, J. M., Antoine, M. H., Lebrun, P. H., & Pirotte, B. (May 1999). Conception, synthèse et évaluation pharmacologique de nouveaux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux potassiques ATP-dépendants [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Boverie, S., De Tullio, P., Somers, F., Lebrun, P., & Pirotte, B. (May 1999). Les 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxydes structuralement apparentés au diazoxide en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Dorwald, F. Z., Hansen, J. B., Mogensen, J. P., Tagmose, T. M., Pirotte, B., Lebrun, P., De Tullio, P., Boverie, S., & Delarge, J. (08 February 1999). Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use.

Somers, F., De Tullio, P., Boverie, S., Dogne, J.-M., Antoine, M.-H., Lebrun, P., & Pirotte, B. (1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation. Fundamental and Clinical Pharmacology, 13, 607.
Peer Reviewed verified by ORBi

Khelili, S., Nguyen, Q.-A., Lebrun, P., Delarge, J., & Pirotte, B. (1999). Synthesis and pharmacological evaluation of KATP-channel openers related to cromakalim: introduction of arylsulphonylurea moieties. Pharmacy and Pharmacology Communications, 5, 189-193.
Peer reviewed

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1999). Effective resolution of racemic pirlindole at the preparative scale. Chirality, 11, 261-266. doi:10.1002/(SICI)1520-636X(1999)11:4<261::AID-CHIR1>3.0.CO;2-S
Peer Reviewed verified by ORBi

Boverie, S., Nguyen, Q.-A., De Tullio, P., Somers, F., Pirotte, B., & Lebrun, P. (1999). Pharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide. Fundamental and Clinical Pharmacology, 13, 605.
Peer Reviewed verified by ORBi

De Tullio, P., Khelili, S., Ouedraogo, R., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Antoine, M.-H., Delarge, J., Lebrun, P., & Pirotte, B. (1999). 3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry. Pharmacy and Pharmacology Communications, 5, 195-198.
Peer reviewed

Dupont, L., De Tullio, P., Khelili, S., Somers, F., Delarge, J., & Pirotte, B. (1999). 7-Chloro-(R)-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide and 7-chloro-(S)-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, C55, 1945-1947. doi:10.1107/S0108270199010069
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Morain, P., Lestage, P., & Lebrun, P. (1999). Pyrido- and benzothiadiazine dioxides related to diazoxide: structural requirements leading to a KATP channel activator or to an allosteric modulator of the AMPA receptors. Fundamental and Clinical Pharmacology, 13, Suppl. 1, 134.
Peer Reviewed verified by ORBi

Ouedraogo, R., Nguyen, Q.-A., Antoine, M.-H., Fontaine, J., Somers, F., De Tullio, P., Pirotte, B., & Lebrun, P. (1999). Pharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides. Fundamental and Clinical Pharmacology, 13, 245.
Peer Reviewed verified by ORBi

De Tullio, P., Delarge, J., & Pirotte, B. (1999). Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists). Current Medicinal Chemistry, 6, 433-455.
Peer Reviewed verified by ORBi

Lebrun, P., Ouedraogo, R., Nguyen, Q.-A., Antoine, M.-H., Dunne, M. J., Pirotte, B., & Masereel, B. (1999). In vivo et in vitro effect of new glibenclamide isosteres. Fundamental and Clinical Pharmacology, 13, Suppl. 1, 381.
Peer Reviewed verified by ORBi

De Tullio, P., Ouedraogo, R., Dupont, L., Somers, F., Boverie, S., Dogne, J.-M., Delarge, J., & Pirotte, B. (1999). Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides: a new class of heterocyclic compounds with therapeutical promises. Tetrahedron, 55, 5419-5432. doi:10.1016/S0040-4020(99)00231-8
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., Podona, T., Diouf, O., Delarge, J., & De Tullio, P. (1999). 4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C55, 461-464. doi:10.1107/S0108270198013894
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., & De Tullio, P. (1999). 7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, C55, 1152-1154. doi:10.1107/S0108270199000669
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Doucet, C., Pochet, L., Thierry, N., Pirotte, B., Delarge, J., & Reboud-Ravaux, M. (1999). 6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for selective inhibitors of human leucocyte elastase. Journal of Medicinal Chemistry, 42, 4161-4171. doi:10.1021/jm990070k
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Khelili, S., De Tullio, P., Lebrun, P., Fillet, M., Antoine, M.-H., Ouedraogo, R., Dupont, L., Fontaine, J., Felekidis, A., Leclerc, G., Delarge, J., & Pirotte, B. (1999). Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers. Bioorganic and Medicinal Chemistry, 7 (8), 1513-1520. doi:10.1016/S0968-0896(99)00082-6
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Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Pirotte, B., Pochet, L., Masereel, B., & Lebrun, P. (12 December 1998). In vivo and in vitro effect of new glibenclamide isosteres [Paper presentation]. Annual Meeting of the FRSM Contact Group Endocrine Pancreas, Liège, Belgium.

Reboud-Ravaux, M., Pochet, L., Doucet, C., Pirotte, B., Boggetto, N., & Delarge, J. (10 December 1998). Coumarin derivatives, methods of preparation and application as medicines.

Dogne, J. M., De Leval, X., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Neven, P., Delarge, J., & Masereel, B. (27 November 1998). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoïd thromboxane A2 receptor antagonists [Paper presentation]. Annual Meeting of the Belgian Society on Thrombosis and Haemostasis, Zemst, Belgium.

Dogne, J. M., De Leval, X., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Neven, P., Delarge, J., & Masereel, B. (27 November 1998). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane A2 receptor antagonists [Poster presentation]. Annual meeting of the Belgian Society on thrombosis and haemostasis, Zemst, Belgium.

Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Fontaine, J., Somers, F., De Tullio, P., Pirotte, B., & Lebrun, P. (21 November 1998). Pharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Anvers, Belgium.

Pirotte, B., Diouf, O., Podona, T., De Tullio, P., Delarge, J., Morain, P., & Lestage, P. (September 1998). 2,3-Dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Somers, F., Boverie, S., Delarge, J., Lebrun, P., & Pirotte, B. (September 1998). Synthesis and biological evaluation of the 3-alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potential KATP channels openers [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Effective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

Khelili, S., Nguyen, Q. A., Lebrun, P., Delarge, J., & Pirotte, B. (September 1998). Synthesis and pharmacological evaluation of ATP-sensitive potassium channel openers related to cromakalim: introduction of arylsulfonylurea or benzothiadiazinedioxide moieties [Poster presentation]. Ninth FECHEM conference on heterocycles in bioorganic chemistry, Aussois, France.

Pochet, L., Doucet, C., Pirotte, B., Thierry, N., Masereel, B., Delarge, J., & Reboud-Ravaux, M. (September 1998). Novel 2-oxo-2H-benzopyran derivatives as inhibitors of human leukocyte elastase [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Somers, F., Boverie, S., Delarge, J., Lebrun, P., & Pirotte, B. (September 1998). 3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

Doucet, C., Pochet, L., Thierry, N., Masereel, B., Reboud-Ravaux, M., & Pirotte, B. (July 1998). New specific inhibitors of human leukocyte elastase [Poster presentation]. FEBS Congress.

Pirotte, B., Ouedraogo, R., De Tullio, P., Antoine, M. H., Somers, F., Fontaine, J., Delarge, J., & Lebrun, P. (May 1998). Les 3-alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxydes structuralement apparentés au diazoxide et au pinacidil: conception, synthèse et évaluation biologique [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Boverie, S., Pirotte, B., Somers, F., Lacan, F., Dogne, J. M., Delarge, J., & De Tullio, P. (May 1998). Utilisation du 1,1’-thiocarbonyldiimidazole comme agent de cyclisation des aminoarylsulfonamides en vue de l’obtention d’intermédiaires utilisables dans la synthèse de nouveaux activateurs de canaux KATP [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

De Tullio, P., Somers, F., Boverie, S., Dupont, L., Ouedraogo, R., Lebrun, P., Fontaine, J., & Pirotte, B. (May 1998). Les 3-alkylamino[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu’activateurs des canaux KATP: détermination de la position de la liaison double du cycle thiadiazine [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Khelili, S., Nguyen, Q. A., Lebrun, P., Delarge, J., & Pirotte, B. (May 1998). Synthèse et évaluation pharmacologique de nouvelles benzopyranes en tant qu’activateurs de canaux potassiques sensibles à l’ATP: introduction d’un groupement arylsulfonylurée ou benzothiadiazinedioxyde en position 4 [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

De Tullio, P., Somers, F., Boverie, S., Dupont, L., Khelili, S., Ouedraogo, R., Fontaine, J., Antoine, M. H., Delarge, J., & Pirotte, B. (May 1998). Les 3-alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant quactivateurs de canaux KATP: étude structurale et influence de la stéréochimie [Paper presentation]. Journées Franco-Belges de Pharmacochimie, Caen, France.

Ouedraogo, R., Nguyen, Q. A., Fontaine, J., Somers, F., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 1998). Les arylthiadiazinedioxydes en tant qu’activateurs des canaux potassiques: etude pharmacologique des 3-alkylamino-2-méthyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

De Tullio, P., Khelili, S., Fillet, M., Ouedraogo, R., Dupont, L., Antoine, M. H., Lebrun, P., Fontaine, J., Delarge, J., & Pirotte, B. (May 1998). Résolutions énantiomériques et évaluations biologiques des isomères du BPDZ 42 et du BPDZ 44 [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M. H., Fontaine, J., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (14 February 1998). New quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers [Paper presentation]. Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Somers, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M. H., Damas, J., Dogne, J. M., Delarge, J., & Pirotte, B. (16 January 1998). Nouvelles 2-alkylamino-quinazoline-4-ones, synthèse et évaluation pharmacologique en tant qu’isostères potentiels de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Paper presentation]. Journées Jeunes Chercheurs, Paris, France.

De Tullio, P., Ceccato, A., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (16 January 1998). Séparation énantiomérique du pirlindole à l’échelle préparative [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration. European Journal of Pharmaceutical Sciences, suppl.1, 37.
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Somers, F., Rogister, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M.-H., Pochet, L., Dogne, J.-M., Masereel, B., Delarge, J., & Pirotte, B. (1998). Design, synthèse et évaluation pharmacologique de nouvelles 2-alkylamino-quinazoline-4-ones en tant du’isostères de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes. Journal de Pharmacie de Belgique, 53, 56.
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Masereel, B., Ouedraogo, R., Dogne, J.-M., Antoine, M.-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Lebrun, P. (1998). Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas. Journal de Pharmacie de Belgique, 53, 57-58.
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Masereel, B., De Tullio, P., Dogne, J.-M., Lacan, F., Pirotte, B., Pochet, L., Somers, F., & Delarge, J. (1998). Design of new potential hypoglycemic drugs. Journal de Pharmacie de Belgique, 53, 58.
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De Tullio, P., Felikidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindol, journées franco-belges de pharmacochimie. Journal de Pharmacie de Belgique, 53, 55.
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Pirotte, B., De Tullio, P., Stachow, M., Felikidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindol. Journal de Pharmacie de Belgique, 53, 60.
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Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M.-H., Fontaine, J., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (1998). New quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers. Fundamental and Clinical Pharmacology, 12, 306.
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Khelili, S., Pirotte, B., Dupont, L., & Delarge, J. (1998). Conception et synthèses d’activateurs potentiels de canaux potassiques sensibles à l’ATP et bioisostères du BMS 180448. Journal de Pharmacie de Belgique, 53, 56-57.
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De Tullio, P., Felekidis, A., Pirotte, B., Liégeois, J.-F., Stachow, M., Delarge, J., Ceccato, A., Hubert, P., Crommen, J., & Geczy, J. (1998). First preparative enantiomer resolution of pirlindole, a potent antidepressant drug. Helvetica Chimica Acta, 81, 539-547. doi:10.1002/hlca.19980810307
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Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole. Journal de Pharmacie de Belgique, 53, 60.
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De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindole. Journal de Pharmacie de Belgique, 53, 55.
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Ouedraogo, R., Somers, F., Pirotte, B., De Tullio, P., Antoine, M.-H., Lebrun, P., & Fontaine, J. (1998). Etude pharmacologique comparative de quelques 3-alkylamino-4H-1,2,4-benzo- et pyridothiadiazine 1,1-dioxydes, activateurs de canaux potassiques ATP-dépendants. Journal de Pharmacie de Belgique, 53, 61.
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Pirotte, B., Podona, T., Diouf, O., De Tullio, P., Lebrun, P., Dupont, L., Somers, F., Delarge, J., Morain, P., Lestage, P., Lepagnol, J., & Spedding, M. (1998). 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology and structure-activity relationships. Journal of Medicinal Chemistry, 41, 2946-2959. doi:10.1021/jm970694v
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Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Dewalque, D., Neven, P., Masereel, B., Caignard, D.-H., Renard, P., & Delarge, J. (1998). Pyridothiadiazinedioxides structurally related to quinazolinones cholecystokinin/gastrin receptor ligands: synthesis and biological evaluation. European Journal of Pharmaceutical Sciences, 7, 29-40. doi:10.1016/S0928-0987(98)00003-7
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De Tullio, P., Pirotte, B., Somers, F., Boverie, S., Lacan, F., & Delarge, J. (1998). Study of the ring closure reaction of o-aminoarylsulfonamides with 1,1’-thiocarbonyldiimidazole. Tetrahedron, 54, 4935-4942. doi:10.1016/S0040-4020(98)00195-1
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De Tullio, P., Somers, F., Boverie, S., Delarge, J., Lebrun, P., & Pirotte, B. (1998). 3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators. European Journal of Pharmaceutical Sciences, suppl.1, 34.
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Pirotte, B., Lebrun, P., De Tullio, P., Somers, F., Delarge, J., Hansen, J. B., Nielsen, F. E., Hansen, H. C., Mogensen, J. P., & Tagmose, T. M. (31 December 1997). 1,2,4-Benzothiadiazine derivatives, their preparation and use.

Somers, F., Ouedraogo, R., De Tullio, P., Lebrun, P., Antoine, M. H., Fontaine, J., Damas, J., Delarge, J., & Pirotte, B. (13 December 1997). Design and synthesis of novel quinazolinones structurally related to pyridothiadiazine-type potassium channel openers acting on pancreatic B-cells [Paper presentation]. Contact Group “Pancreas Endocrine”, Bruxelles, Belgium.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (September 1997). Simultaneous determination of pirlindole enantiomers and dehydropirlindole by liquid chromatography using a cellulose based chiral stationary phase [Poster presentation]. 7th Meeting on Recent Developments in Pharmaceutical Analysis, Ile d'Elbe, Italy.

Pirotte, B., Lebrun, P., De Tullio, P., Somers, F., Delarge, J., Hansen, H. C., Nielsen, F. E., & Hansen, J. B. (24 July 1997). Pyrido 1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, their preparation and use.

Pirotte, B., De Tullio, P., Ouedraogo, R., Somers, F., Antoine, M. H., Fontaie, J., Delarge, J., & Lebrun, P. (July 1997). 1,2,4-Pyridothiadiazine 1,1-dioxides as a new class of potassium channel openers: structural requirements leading to tissue selectivity [Poster presentation]. XXXIII International Congress of Physiological Sciences IUPS 1997.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Cegzy, J., & Delarge, J. (May 1997). Résolution préparative du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Somers, F., Rogister, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M. H., Pochet, L., Dogne, J. M., Masereel, B., Delarge, J., & Pirotte, B. (May 1997). Design, synthèse et évaluation pharmacologique de nouvelles 2-alkylamino-quinazoline-4-ones en tant du’isostères de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Ouedraogo, R., Somers, F., Pirotte, B., De Tullio, P., Antoine, M. H., Lebrun, P., & Fontaine, J. (May 1997). Etude pharmacologique comparative de quelques 3-alkylamino-4H-1,2,4-benzo- et pyridothiadiazine 1,1-dioxydes, activateurs de canaux potassiques ATP-dépendants [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Masereel, B., Ouedraogo, R., Dogne, J. M., Antoine, M. H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Lebrun, P. (May 1997). Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Masereel, B., De Tullio, P., Dogne, J. M., Lacan, F., Pirotte, B., Pochet, L., Somers, F., & Delarge, J. (May 1997). Design of new potential hypoglycemic drugs [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Khelili, S., Pirotte, B., Dupont, L., & Delarge, J. (May 1997). Conception et synthèses d’activateurs potentiels de canaux potassiques sensibles à l’ATP et bioisostères du BMS 180448 [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (May 1997). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Ouedraogo, R., Somers, F., De Tullio, P., Antoine, M. H., Lebrun, P., Pirotte, B., & Fontaine, J. (April 1997). Pharmacological analysis of ATP-dependent potassium channels openers on vascular smooth muscle [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Masereel, B., Dogne, J. M., Damas, J., Nuhrich, A., Varache-Lembege, M., Fontaine, J., Pochet, L., Somers, F., De Tullio, P., Pirotte, B., & Delarge, J. (April 1997). Pharmacomodulation of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Piel, G., Pirotte, B., Delneuville, I., Neven, P., Llabres, G., Delarge, J., & Delattre, L. (April 1997). Study of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide-L-Lysine-Cyclodextrin Complexes. Journal of Pharmaceutical Sciences, 86 (4), 475-80. doi:10.1021/js960298k
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Somers, F., Rogister, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M. H., Pochet, L., Dogne, J. M., Masereel, B., Delarge, J., & Pirotte, B. (April 1997). 2-Alkylamino-3H-quinazolin-4-ones structurally related to the arylthiadiazine class of potassium channel openers: design, synthesis and pharmacological evaluation [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Dogne, J. M., Varache-Lembege, M., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Pochet, L., Neven, P., Delarge, J., & Masereel, B. (April 1997). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane receptor antagonists [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Lebrun, P., Antoine, M. H., Ouedraogo, R., Pirotte, B., Herchuelz, A., Cosgrove, K. E., Kane, C., & Dunne, M. J. (April 1997). Verapamil: an inhibitor of ATP-sensitive K+ channels? [Poster presentation]. Ion Channels and Exocytosis in Pancreatic Islets, Islet cells and Insulin Secretory Cell Lines, Tübingen, Germany.

Lebrun, P., Pirotte, B., & Antoine, M. H. (08 March 1997). Pharmacologie des canaux K+ATP-dépendants des cellules B pancréatiques: nouveaux développements [Paper presentation]. De la Science à la Pratique Médicale, Genval, Belgium.

Lebrun, P., Pirotte, B., & Antoine, M. H. (15 February 1997). Physiology, pharmacology of ATP-sensitive K+ channels and insulin release [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Fontaine, J., Pirotte, B., & Lebrun, P. (15 February 1997). Pharmacological analysis of ATP-dependent potassium channel openers on the vascular smooth muscle [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dogne, J. M., Varache-Lembeche, M., Damas, J., Nuhrich, A., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Masereel, B. (12 January 1997). Synthèse et évaluation biologique de sulfonylurées en tant qu’antagonistes du thromboxane A2 [Paper presentation]. 4ème Journée Jeunes Chercheurs de la Société de Chimie Thérapeutique, Paris, France.

Pochet, L., Doucet, C., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (10 January 1997). Nouvelles perspectives de développement d’aryl- et de cycloalkylesters de l’acide 6-chlorométhyl-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’inhibiteurs de l’élastase leucocytaire et de l’-chymotrypsine [Poster presentation]. 4ème Journée Jeunes Chercheurs, Paris, France.

Scuvée-Moreau, J., Seutin, V., Vrijens, B., Pirotte, B., De Tullio, P., Massotte, L., Albert, A., Delarge, J., & Dresse, A. (1997). Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro. Archives of Physiology and Biochemistry, 105 (5), 421-8. doi:10.1076/apab.105.5.421.3285
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De Tullio, P., Pirotte, B., Neven, P., Masereel, B., Dewalque, D., Diouf, O., Podona, T., Caignard, D., Renard, P., & Delarge, J. (1997). Synthesis and biological evaluation of new 3-aralkylamino-2-aryl-2H-1,2,4-pyridothiadiazine 1,1-dioxides as potential CCK receptor ligands. Journal of Pharmacy and Pharmacology, 49, 463-471. doi:10.1111/j.2042-7158.1997.tb06825.x
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Neven, P., Dewalque, D., & Delarge, J. (1997). The chemistry of 3-phthalimidomethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides and their use in the synthesis of potential cholecystokinin/gastrin receptor ligands. Bulletin des Sociétés Chimiques Belges, 106, 781-790.
Peer reviewed

Francini, F., Pirotte, B., & Gagliardino, J. J. (1997). Effect of activators and inhibitors of K+-channels on insulin secretion in the amphibian pancreas. Archives of Physiology and Biochemistry, 105, 66-70. doi:10.1076/apab.105.1.66.13141
Peer Reviewed verified by ORBi

Khelili, S., Pirotte, B., Dupont, L., & Delarge, J. (1997). Synthesis and design of potential ATP-sensitive potassium channel openers bearing some structural features of benzopyrans and benzo (pyrido)thiadiazinedioxides52, 2bis. Journal de Pharmacie de Belgique, 52, 29.
Peer Reviewed verified by ORBi

Masereel, B., Ouedraogo, R., Dogne, J.-M., Antoine, M.-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Lebrun, P. (1997). Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas. European Journal of Medicinal Chemistry, 32, 453-456. doi:10.1016/S0223-5234(97)81682-0
Peer Reviewed verified by ORBi

Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., Bregadze, V. I., Dolgushin, F. M., Yanovsky, A. I., & Struchkov, Y. T. (1997). Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes. Molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-Rh C2B9H11]. Journal of Organometallic Chemistry, 536-537, 405-412. doi:10.1016/S0022-328X(96)06743-5
Peer Reviewed verified by ORBi

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (1997). Enantiomeric separation of pirlindole enantiomers and dehydroprilindole by chrial liquid chromatography [Poster presentation]. VIIth meeting on recent developments in pharmaceutical analysis.

Masereel, B., Dogne, J.-M., Damas, J., Nuhrich, A., Varache-Lembege, M., Fontaine, J., Pochet, L., Somers, F., De Tullio, P., Pirotte, B., & Delarge, J. (1997). Pharmacomodulation of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs. Journal de Pharmacie de Belgique, 52, 157-158.
Peer Reviewed verified by ORBi

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Pirotte, B., Herchuelz, A., Cosgrove, K. E., Kane, C., & Dunne, M. J. (1997). Verapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells. Diabetologia, 40, 1403-1410. doi:10.1007/s001250050842
Peer Reviewed verified by ORBi

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Herchuelz, A., De Tullio, P., Delarge, J., & Pirotte, B. (1997). Pyridothiadiazines as potent inhibitors of glucose-induced insulin release. In Physiology and Pathophysiology of the Islets of Langerhans (pp. 145-148). New York, United States - New York: Soria, Plenum Press.

Ouedraogo, R., Pirotte, B., Cosgrove, K. E., Kane, C., Dunne, M. J., Herchuelz, A., Lebrun, P., & Antoine, M. H. (07 December 1996). Verapamil inhibits ATP-sensitive K+ channel in pancreatic B-cells [Paper presentation]. Contact Group “Pancreas Endocrine, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Ouedraogo, R., Dupont, L., Fang, Z. Y., Fontaine, J., Antoine, M. H., Masereel, B., Pochet, L., Delarge, J., & Lebrun, P. (September 1996). Myorelaxant effects of 2-alkyl-substituted 2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides [Poster presentation]. XIVth International Symposium on Medicinal Chemistry, Maastricht, Netherlands.

Doucet, C., Pochet, L., Schynts, M., Thierry, N., Pirotte, B., Delarge, J., & Reboud-Ravaux, M. (September 1996). Progress towards coumarinic derivatives as protease inhibitors [Poster presentation]. XIVth International Symposium on Medicinal Chemistry, Maastricht, Netherlands.

Khelili, S., Pirotte, B., Dupont, L., & Delarge, J. (September 1996). Synthesis and design of potential ATP-sensitive potassium channel openers bearing some structural features of benzopyrans (bioisosteres) and benzo(pyrido)thiadiazinedioxides [Poster presentation]. XIVth International Symposium on Medicinal Chemistry, Maastricht, Netherlands.

Khelili, S., Pirotte, B., & Delarge, J. (May 1996). Synthesis of potential ATP-sensitive potassium channel openers bearing some structural features of benzopyrans and benzo(pyrido)thiadiazinedioxides [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

De Tullio, P., Pirotte, B., Ouedraogo, R., Dupont, L., Lebrun, P., Fang, Z. Y., Masereel, B., Fontaine, J., Antoine, M. H., Neven, P., Pochet, L., & Delarge, J. (May 1996). 2-, 3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Piel, G., Pirotte, B., Delneuville, I., Neven, P., Delarge, J., & Delattre, L. (May 1996). Nimesulide-L-lysine-β- and γ-cyclodextrin complexes: preparation and dissolution properties [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J. M., & Reboud-Ravaux, M. (May 1996). Design and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Pirotte, B., Khelili, S., De Tullio, P., Fang, Z. Y., Ouedraogo, R., Antoine, M. H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J., & Lebrun, P. (May 1996). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Khelili, S., Pirotte, B., Dupont, L., & Delarge, J. (May 1996). Synthesis and design of potential ATP-sensitive potassium channel openers bearing some structural features of benzopyrans and benzo(pyrido)thiadiazinedioxides [Poster presentation]. 10èmes Journées Franco-Belges de Pharmacochimie, Luxembourg, Luxembourg.

Masereel, B., Lambert, D., Dogne, J. M., De Tullio, P., Pirotte, B., Pochet, L., & Delarge, J. (May 1996). BM 34, an anticonvulsant sulfonylthiourea with a phenitoin-like profile [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Piel, G., Pirotte, B., Delneuville, I., Neven, P., Delarge, J., & Delattre, L. (February 1996). Preparation by spray drying of b and g-cyclodextrin inclusion complexes of a poorly soluble non steroidal anti-inflammatory drug [Poster presentation]. Formulation of Poorly-Available Drugs for Oral Administration, European Symposium, Paris, France.

Pirotte, B., Ouedraogo, R., Fang, Z. Y., De Tullio, P., Khelili, S., Fontaine, J., Lebrun, P., Pochet, L., Masereel, B., Dupont, L., & Delarge, J. (12 January 1996). Les 3-alkylamino-2-méthyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant que nouveaux agents myorelâchants [Poster presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Masereel, B., Varache-Lembege, M., Damas, J., Nuhrich, A., De Tullio, P., Khelili, S., Pirotte, B., Pochet, L., & Delarge, J. (12 January 1996). Synthèse et évaluation biologique d’antagonistes non-carboxyliques du récepteur au thromboxane A2 [Poster presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., & Reboud-Ravaux, M. (12 January 1996). Conception et synthèse de dérivés de l’acide 6-(chloro)méthyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu’inhibiteurs de l’élastase leucocytaire et de l’α-chymotripsine [Paper presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Khelili, S., Pirotte, B., De Tullio, P., Lebrun, P., Ouedraogo, R., Antoine, M. H., Fang, Z. Y., Fontaine, J., Masereel, B., & Delarge, J. (12 January 1996). Pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides: novel class of vasorelaxant drugs [Poster presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Doucet, C., Pochet, L., Schynts, M., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (1996). Nouveaux dérivés de l'acide 6-chlorométhyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu'inhibiteurs de protéases à sérine: étude des relations structure-activité expliquant leur sélectivité d'action. Journal de Pharmacie de Belgique, 51, 18.
Peer Reviewed verified by ORBi

De Tullio, P., Pirotte, B., Ouedraogo, R., Dupont, L., Lebrun, L., Fang, Z. Y., Masereel, B., Fontaine, J., Antoine, M.-H., Neven, P., Pochet, L., & Delarge, J. (1996). 2-, 3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers. Journal de Pharmacie de Belgique, 51, 108.
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., De Tullio, P., & Delarge, J. (1996). 3-Isopropylamino-4-methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide. Acta Crystallographica, C52, 1741-1743. doi:10.1107/S0108270196001941
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., & Lebrun, P. (1996). Recent advances in drugs acting as tissue selective potassium channel openers. Potassium Channel Modulators; ID Research Alert, 1, 4.
Peer reviewed

Malaisse, W. J., Lebrun, P., Pirotte, B., Van Poelje, P. D., Vinambres, C., Villanueva-Penacarrillo, M. L., Valverde, I., Gabel, J., & Rorsman, P. (1996). The riddle of formycin A insulinotropic action. Biochemical and Molecular Medicine, 57, 47-63. doi:10.1006/bmme.1996.0008
Peer Reviewed verified by ORBi

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (1996). Design and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin. Journal de Pharmacie de Belgique, 51, 117.
Peer Reviewed verified by ORBi

De Tullio, P., Pirotte, B., Lebrun, P., Fontaine, J., Dupont, L., Antoine, M.-H., Ouedraogo, R., Maggetto, C., Masereel, B., Khelili, S., Diouf, O., Podona, T., & Delarge, J. (1996). 3- and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation and structure-activity relationships. Journal of Medicinal Chemistry, 39, 937-948. doi:10.1021/jm9500582
Peer Reviewed verified by ORBi

Masereel, B., Lebrun, P., Dogne, J.-M., De Tullio, P., Pirotte, B., Pochet, L., Diouf, O., & Delarge, J. (1996). First synthesis of 4-substituted benzenesulfonylcyanoguanidines. Tetrahedron Letters, 37, 7253-7254. doi:10.1016/0040-4039(96)01663-2
Peer Reviewed verified by ORBi

Piel, G., Pirotte, B., Delneuville, I., Neven, P., Delarge, J., & Delattre, L. (1996). Nimesulide-L-lysine-β- and γ-cyclodextrin complexes: preparation and dissolution properties. Journal de Pharmacie de Belgique, 51, 117.
Peer Reviewed verified by ORBi

Khelili, S., Pirotte, B., & Delarge, J. (1996). Synthesis of potential ATP-sensitive potassium channel openers bearing some structural features of benzopyrans and benzo(pyrido)thiadiazinedioxides. Journal de Pharmacie de Belgique, 51, 113.
Peer Reviewed verified by ORBi

Ouedraogo, R., Pirotte, B., Antoine, M. H., De Tullio, P., Masereel, B., Dunne, M., Kane, C., & Lebrun, P. (1996). Les canaux potassiques ATP-dépendants et la sécrétion d'insuline: effets du BPDZ 62. Journal de Pharmacie de Belgique, 51, 41.
Peer Reviewed verified by ORBi

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Dunne, M., Kane, C., Hermann, M., Herchuelz, A., Masereel, B., Delarge, J., De Tullio, P., & Pirotte, B. (1996). Activation of ATP-dependant K+ channels and inhibition of insulin release: effect of BPDZ 62. Journal of Pharmacology and Experimental Therapeutics, 277, 156-162.
Peer Reviewed verified by ORBi

Khelili, S., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1996). Nouvelles stratégies de synthèse vers des pyridothiadiazinedioxydes structuralement apparentés au diazoxide. Journal de Pharmacie de Belgique, 51, 19.
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., De Tullio, P., & Delarge, J. (1996). Absolute configuration of (R)-1-phenylethyl ammonium (S)-2-(6-methoxy-2-naphthyl)-propionate. Acta Crystallographica, C52, 393-395.
Peer Reviewed verified by ORBi

Pirotte, B., Khelili, S., De Tullio, P., Fang, Z. Y., Ouedraogo, R., Antoine, M.-H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J., & Lebrun, P. (1996). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers. Journal de Pharmacie de Belgique, 51, 117.
Peer Reviewed verified by ORBi

Diouf, O., Pirotte, B., Podona, T., De Tullio, P., Masereel, B., Delarge, J., Morain, P., & Lepagnol, J. (1996). Synthèse de nouvelles pyridothiadiazines et leur évaluation en tant que modulateurs des récepteurs glutamatergiques à l'acide a-amino-3-hydroxy-5-méthyl-4-isoxazolepropionique. Journal de Pharmacie de Belgique, 51, 20.
Peer Reviewed verified by ORBi

Ouedraogo, R., Pirotte, B., Antoine, M.-H., De Tullio, P., Masereel, B., Dunne, M., Kane, C., & Lebrun, P. (1996). Les canaux potassiques ATP-dépendants et la sécrétion d'insuline: effet du BPDZ 62. Journal de Pharmacie de Belgique, 51, 41.
Peer Reviewed verified by ORBi

Masereel, B., Lambert, D., Dogne, J.-M., De Tullio, P., Pirotte, B., Pochet, L., & Delarge, J. (1996). BM 34, an anticonvulsant sulfonylthiourea with a phenitoin-like profile. Journal de Pharmacie de Belgique, 51, 115.
Peer Reviewed verified by ORBi

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Jiang, K. Y., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (1996). Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of a-chymotrypsin: significance of the ‘aromatic’ nature of the novel ester-type coumarin for strong inhibitory activity. Journal of Medicinal Chemistry, 39, 2579-2585. doi:10.1021/jm960090b
Peer Reviewed verified by ORBi

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (1996). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas. Journal de Pharmacie de Belgique, 51, 17.
Peer Reviewed verified by ORBi

Pirotte, B., Piel, G., Delneuville, I., Neven, P., & Geczy, J. (21 December 1995). WATER-SOLUBLE NIMESULIDE SALT, AND USES THEREOF FOR THE TREATMENT OF INFLAMMATIONS.

Kane, C., Harding, E. A., Antoine, M. H., Lebrun, P., Pirotte, B., James, R. F. L., Johnson, P. R. V., Lindley, K. J., & Dunne, M. (September 1995). Activation of potassium channels in human and rodent B-cells by BPDZ-44 and BPDZ-62; mechanisms of action and effects in human neonatal nesidioblastosis [Poster presentation]. 31st Annual Meeting of the European Association for the Study of Diabetes, Stockholm, Sweden.

Fontaine, J., Maranca, F., Vladut-Vasilan, C., Pirotte, B., Antoine, M. H., & Lebrun, P. (September 1995). Pharmacological study of new potassium channel openers (3- and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides) on pancreatic and vascular tissues [Poster presentation]. 10th Camerino-Noordwijkerhout Symposium: Perspectives in Receptor Research, Camerino, Italy.

Lebrun, P., Antoine, M. H., Ouedraogo, R., Herchuelz, A., Dunne, M., Kane, C., De Tullio, P., Delarge, J., & Pirotte, B. (September 1995). ATP-sensitive K+ channels and insulin release: effect of BPDZ 62 [Poster presentation]. 31st Annual Meeting of the European Association for the Study of Diabetes, Stockholm, Sweden.

Khelili, S., Leclerc, G., Faury, G., Verdetti, J., Pirotte, B., Fontaine, J., & Lebrun, P. (July 1995). Nouveaux agents vasodilatateurs apparentés au diazoxide portant une fonction sulfonylurée ayant un effet agoniste probable sur les canaux potassiques sensibles à l'ATP [Paper presentation]. Forum des Jeunes Chercheurs, Grenoble, France.

Scuvée-Moreau, J., Seutin, V., Pirotte, B., De Tullio, P., Massotte, L., Delarge, J., & Dresse, A. (08 June 1995). Comparative effect of various potassium channel openers on the firing rate of hippocampal and dopaminergic neurons in vitro [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Ouedraogo, R., Pirotte, B., Antoine, M. H., De Tullio, P., Masereel, B., Dunne, M., Kane, C., & Lebrun, P. (June 1995). Les canaux potassiques ATP-dépendants et la sécrétion d'insuline: effets du BPDZ 62 [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (June 1995). Synthesis and diuretic properties of pyrid-3-ylsulfonylcyanoguanidines [Poster presentation]. 31èmes Rencontres Internationales de Chimie Thérapeutique, Lyon, France.

Khelili, S., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (June 1995). Nouvelles stratégies de synthèse vers des pyridothiadiazinedioxydes structuralement apparentés au diazoxide [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Doucet, C., Pochet, L., Schynts, M., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., Delarge, J., & Reboud-Ravaux, M. (June 1995). Nouveaux dérivés de l'acide 6-chlorométhyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu'inhibiteurs de protéases à sérine: étude des relations structure-activité expliquant leur sélectivité d'action [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (June 1995). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Diouf, O., Pirotte, B., Podona, T., De Tullio, P., Masereel, B., Delarge, J., Morain, P., & Lepagnol, P. (June 1995). Synthèse de nouvelles pyridothiadiazines et leur évaluation en tant que modulateurs des récepteurs glutamatergiques à l'acide a-amino-3-hydroxy-5-méthyl-4-isoxazolepropionique [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Pirotte, B., Antoine, M. H., Lebrun, P., Maggetto, C., Fontaine, J., Masereel, B., & Delarge, J. (18 February 1995). Pyrido- and benzothiadiazinedioxides structurally related to diazoxide: new activators of the pancreatic and vascular KATP channels [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Ouedraogo, R., Antoine, M. H., De Tullio, P., Dunne, M., Kane, C., Pirotte, B., & Lebrun, P. (18 February 1995). ATP-sensitive K+ channels and insulin release: effect of BPDZ 62 [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

De Tullio, P., Pirotte, B., Fontaine, J., Antoine, M. H., Masereel, B., Diouf, O., Podona, T., Delarge, J., & Lebrun, P. (12 January 1995). Nouveaux 1,2,4-pyrido- et benzothiadiazine 1,1-dioxydes, analogues du diazoxide et puissants activateurs du canal potassique ATP-dépendant: synthèse, evaluation biologique et sélectivité tissulaire [Poster presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

Pochet, Doucet, C., Schynts, M., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (12 January 1995). Synthèse et évaluation enzymatique de nouveaux dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine [Poster presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

Masereel, B., Laeckmann, D., Dupont, L., Pirotte, B., De Tullio, P., Diouf, O., & Delarge, J. (12 January 1995). Synthesis and diuretic properties of novel pyrid-3-ylsulfonylcyanoguanidines [Poster presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

De Tullio, P., Pirotte, B., Fontaine, J., Antoine, M. H., Masereel, B., Diouf, O., Podona, T., Delarge, J., & Lebrun, P. (12 January 1995). Nouveaux 1,2,4-pyrido- et benzothiadiazine 1,1-dioxydes, analogues du diazoxide et puissants activateurs du canal potassique ATP-dépendant: synthèse, evaluation biologique et sélectivité tissulaire [Paper presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

Dupont, L., Pirotte, B., De Tullio, P., Diouf, O., Masereel, B., & Delarge, J. (1995). 2,4,7-Trimethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazinium 1,1-dioxide iodide. Acta Crystallographica, C51, 2412-2414. doi:10.1107/S0108270195008006
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3-Methyl-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 2064-2066.
Peer Reviewed verified by ORBi

Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., & Bregadze, V. I. (1995). Influence de la nature des ligands sur l'hydrogenation de la méthacycline en doxycycline et en épi-doxycycline par des complexes du Rhodium. Journal de Pharmacie de Belgique, 50, 232.
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Podona, T., Masereel, B., Caignard, D.-H., Renard, P., & Delarge, J. (1995). 3-Arylcarboxamidométhyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu'antagonistes non peptidiques de la cholécystokinine: synthèse et évaluation pharmacologique. Journal de Pharmacie de Belgique, 50, 253.
Peer Reviewed verified by ORBi

De Tullio, P., Pirotte, B., Antoine, M.-H., Lebrun, P., Maggetto, C., Fontaine, J., Masereel, B., & Delarge, J. (1995). Pyrido- and benzothiadiazinedioxides structurally related to diazoxide: new activators of the pancreatic and vascular KATP channels. Pflügers Archiv: European Journal of Physiology, 430, 8.
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Pirotte, B., Fontaine, J., & Lebrun, P. (1995). Recent advances in the chemistry of potassium channel openers. Current Medicinal Chemistry, 2, 573-582.
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De Tullio, P., Pirotte, B., Dupont, L., Masereel, B., Laeckmann, D., Podona, T., Diouf, O., Lebrun, P., & Delarge, J. (1995). Synthesis ans structural studies of a new class of heterocyclic compounds: 1,2,4-pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides. Tetrahedron, 51, 3221-3234.
Peer Reviewed verified by ORBi

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3-amino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate and 3-tert-butyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 1385-1388. doi:10.1107/S0108270195000278
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Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (1995). Synthesis and pharmacology of N"-(4-arylaminopyrid-3-yl)sulfonyl-N-cyano-N'-isopropyl-guanidines. Journal de Pharmacie de Belgique, 50, 250.
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Dupont, L., De Tullio, P., Pirotte, B., Masereel, B., & Delarge, J. (1995). 3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 1903-1905.
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De Tullio, P., Pirotte, B., Masereel, B., Diouf, O., Caignard, D.-H., Renard, P., & Delarge, J. (1995). Synthèse de dérivés 3-aminoaralkyl-2-aryl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes et leur évaluation en tant qu'antagonistes de la cholécystokinine. Journal de Pharmacie de Belgique, 50, 244.
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Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (1995). Synthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics. European Journal of Medicinal Chemistry, 30, 343-351. doi:10.1016/0223-5234(96)88244-4
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Kane, C., Harding, E. A., Antoine, M.-H., Lebrun, P., Pirotte, B., James, R. F. L., Johnson, P. R. V., Lindley, K. J., & Dunne, M. (1995). Activation of potassium channels in human and rodent B-cells by BPDZ-44 and BPDZ-62; mechanisms of action and effects in human neonatal nesidioblastosis. Diabetologia, 38, 124.
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Dupont, L., Masereel, B., De Tullio, P., Pirotte, B., & Delarge, J. (1995). N2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine. Acta Crystallographica, C51, 505-507.
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Dupont, L., Pirotte, B., Masereel, B., Delarge, J., & Geczy, J. (1995). Nimesulide. Acta Crystallographica, C51, 507-509. doi:10.1107/S0108270194010334
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Scuvée-Moreau, J., Seutin, V., Pirotte, B., De Tullio, P., Massotte, L., Delarge, J., & Dresse, A. (1995). Comparative effect of various potassium channel openers on the firing rate of hippocampal and dopaminergic neurons in vitro. Pflügers Archiv: European Journal of Physiology, 430, 182.
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Dupont, L., De Tullio, P., Pirotte, B., Masereel, B., & Delarge, J. (1995). 7-Methyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-ide 1,1-dioxide zwitterion. Acta Crystallographica, C51, 2416-2417. doi:10.1107/S0108270195008031
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Lebrun, P., Antoine, M.-H., Ouedraogo, R., Herchuelz, A., Dunne, M., Kane, C., De Tullio, P., Delarge, J., & Pirotte, B. (1995). ATP-sensitive K+ channels and insulin release: effect of BPDZ 62. Diabetologia, 38, 195.
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Dupont, L., De Tullio, P., Pirotte, B., Masereel, B., & Delarge, J. (1995). 3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate. Acta Crystallographica, C51, 946-948. doi:10.1107/S0108270194013235
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Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3,7-Dimethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide zwitterion. Acta Crystallographica, C51, 2414-2416. doi:10.1107/S010827019500802X
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Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3-Methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 944-946.
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Pirotte, B., Fontaine, J., & Lebrun, P. (1995). Nouveaux activateurs des canaux potassiques: conception, pharmacologie et perspectives thérapeutiques. Journal de Pharmacie de Belgique, 50, 167-178.
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Kane, C., Harding, E. A., Pirotte, B., Lebrun, P., & Dunne, M. J. (1995). Modulation and mechanism of action of BPDZ 44 on ATP-sensitive potassium channels in isolated rat insulin-secreting cells. Journal of Physiology, 482 P, 11.
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Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). Les activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim. Annales Pharmaceutiques Françaises, 53 (5), 201-208.
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Pirotte, B., De Tullio, P., Antoine, M. H., Masereel, B., Delarge, J., & Lebrun, P. (10 December 1994). Selection of a new and potent activator of the pancreatic KATP channel based on structure-activity relationships in the pyridothiadiazinedioxide chemical class [Paper presentation]. Contact group FNRS "Endocrine Pancreas", Bruxelles, Belgium.

Lebrun, P., Antoine, M. H., Ouedraogo, R., Herchuelz, A., De Tullio, P., Masereel, B., Delarge, J., & Pirotte, B. (10 December 1994). Pyridothiadiazines inhibit glucose-induced insulin release by activating ATP-sensitive K+ channels [Paper presentation]. Contact group FNRS "Endocrine Pancreas", Bruxelles, Belgium.

Kane, C., Harding, E. A., Pirotte, B., Lebrun, P., & Dunne, M. J. (November 1994). Modulation and mechanism of action of BPDZ 44 on ATP-sensitive potassium channels in isolated rat insulin-secreting cells [Poster presentation]. Physiological Society, Newcastle, Newcastle, United Kingdom.

Pirotte, B., De Tullio, P., Masereel, B., Delarge, J.-L., Lepagnol, J., & Renard, P. (05 October 1994). Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them.

De Tullio, P., Pirotte, B., Fontaine, J., Antoine, M. H., Masereel, B., Delarge, J., & Lebrun, P. (October 1994). Different tissue selectivity of pyrido- and benzothiadiazinedioxides, potassium channel openers related to diazoxide [Poster presentation]. 6th International Symposium: Pharmacological control of calcium and potassium homeostasis, Florence, Italy.

Pirotte, B., De Tullio, P., Antoine, M. H., Masereel, B., Delarge, J., & Lebrun, P. (October 1994). Structure-activity relationships of pyridothiadiazines that activate the pancreatic KATP channel: a proposed pharmacophore for optimal binding site interaction [Poster presentation]. 6th International Symposium: Pharmacological control of calcium and potassium homeostasis, Florence, Italy.

Lebrun, P., De Tullio, P., Antoine, M. H., Herchuelz, A., Delarge, J., & Pirotte, B. (October 1994). Pyridothiadiazines as potent activators of KATP channels and inhibitors of insulin secretion [Poster presentation]. 6th International Symposium: Pharmacological control of calcium and potassium homeostasis, Florence, Italy.

Masereel, B., Renard, P., Pirotte, B., De Tullio, P., & Delarge, J. (September 1994). A novel pyrid-3-yl sulfonylurea, BM 27, effective in brain edema and stroke treatment [Paper presentation]. XIIIth International Symposium of Medicinal Chemistry, Paris, France.

Kane, C., Harding, E. A., Pirotte, B., Lebrun, P., & Dunne, M. J. (September 1994). Inhibition of insulin secretion by BPDZ 44 involves the activation of ATP-sensitive K+ channels [Poster presentation]. Autumn Meeting of the British Diabetic Association, Lancaster University, Lancaster, United Kingdom.

Reboud-Ravaux, M., Thierry, N., Schynts, M., Jiang, K. Y., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., & Delarge, J. (September 1994). Synthesis and enzymatic evaluation of novel coumarinic derivatives as inhibitors of serine proteases [Poster presentation]. XIIIth International Symposium of Medicinal Chemistry, Paris, France.

Pirotte, B., De Tullio, P., Masereel, B., Diouf, O., Caignard, D. H., Renard, P., & Delarge, J. (September 1994). Benzo- and pyridothiadiazinedioxides as nonpeptidal cholecystokinin antagonists related to quinazolinones cholecystokinin/gastrin receptor ligands [Poster presentation]. XIIIth International Symposium of Medicinal Chemistry, Paris, France.

Scuvée-Moreau, J., Pirotte, B., Seutin, V., Massote, L., De Tullio, P., Delarge, J., & Dresse, A. (June 1994). Effect of potassium channel openers on the firing rate of hippocampal pyramidal neurons in vitro [Poster presentation]. GESA XXIV, Nîmes, France.

De Tullio, P., Pirotte, B., Masereel, B., Diouf, O., Caignard, D. H., Renard, P., & Delarge, J. (May 1994). Synthèse de dérivés 3-aminoaralkyl-2-aryl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes et leur evaluation en tant qu'antagonistes de la cholécystokinine [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Masereel, M. B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (May 1994). Synthesis and pharmacology of N"-(4-arylaminopyrid-3-yl)sulfonyl-N-cyano-N'-isopropylguanidines [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Schynts, M., Boggetto, N., Jiang, K. Y., Thierry, N., Masereel, B., Pirotte, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (May 1994). Développement d'une nouvelle serie d'inactivateurs de protéases à sérine [Poster presentation]. RECOB 5, Aussois, France.

Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., & Bregadze, V. I. (May 1994). Influence de la nature des ligands sur l'hydrogénation de la méthacycline en doxycycline et en épi-doxycycline par des complexes du Rhodium [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Pirotte, B., De Tullio, P., Podona, T., Masereel, Caignard, D. H., Renard, P., & Delarge, J. (May 1994). 3-Arylcarboxamidomethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu'antagonistes non peptidiques de la cholécystokinine: synthèse et évaluation pharmacologique [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

De Tullio, P., Pirotte, B., Dupont, L., Lebrun, P., Antoine, M. H., Fontaine, J., Masereel, B., Schynts, M., & Delarge, J. M. (March 1994). Synthesis of a series of 4H-1,2,4-pyridothiadiazine 1,1-dioxides and their evaluation as new potassium channel openers [Paper presentation]. Cinquième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. M. (March 1994). Pharmacology of a new sulfonylurea (BM 27) effective in brain edema [Paper presentation]. Cinquième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Schynts, M., Jiang, K. Y., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (19 January 1994). Design, synthèse et évaluation biologique de nouveaux dérivés coumariniques inhibiteurs de protéases à sérine [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

De Tullio, P., Pirotte, B., Lebrun, P., Antoine, M. H., Fontaine, J., Masereel, B., Schynts, M., Dupont, L., & Delarge, J. (19 January 1994). 4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que nouveaux activateurs du canal potassique ATP-dépendant [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

Pirotte, B., Antoine, M.-H., De Tullio, P., Hermann, M., Herchuelz, A., Delarge, J., & Lebrun, P. (1994). A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+-channels. Biochemical Pharmacology, 47, 1381-1386. doi:10.1016/0006-2952(94)90337-9
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De Tullio, P., Pirotte, B., Dupont, L., Lebrun, P., Antoine, M.-H., Fontaine, J., Masereel, B., Schynts, M., & Delarge, J. (1994). Synthesis of a series of 4H-1,2,4-pyridothiadiazine 1,1-dioxides and their evaluation as new potassium channel openers. Journal de Pharmacie de Belgique, 49, 85.
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Masereel, B., Renard, P., Pirotte, B., De Tullio, P., & Delarge, J. (1994). Synthesis and pharmacology of pyrid-3-yl sulfonylureas and thioureas as astrocytic Na+ 2Cl- K+ cotransporter inhibitors. European Journal of Medicinal Chemistry, 29, 527-535. doi:10.1016/0223-5234(94)90145-7
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Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (1994). Pharmacology of a new sulfonylurea (BM 27) effective in brain edema. Journal de Pharmacie de Belgique, 49, 88.
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Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (1994). Etude structurale comparative du pinacidil, du diazoxide et du cromakalim, ouvreurs de canaux potassiques appartenant à trois classes chimiques distinctes. Journal de Pharmacie de Belgique, 49, 282.
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Fesquet, S., Schynts, M., Boggetto, N., Masereel, B., Pirotte, B., Delarge, J., Jiang, K. Y., & Reboud-Ravaux, M. (1994). A novel coumarinic inhibitor inactivates cathepsin G but not human leucocyte elastase. Journal de Pharmacie de Belgique, 49, 258.
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Antoine, M.-H., Pirotte, B., Hermann, M., De Tullio, P., Herchuelz, A., Delarge, J., & Lebrun, P. (1994). Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets. Experientia, 50, 830-832. doi:10.1007/BF01956464
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Demonceau, A., Fontaine, M., Noels, A. F., Felekidis, A., Pirotte, B., Delarge, J., Chizhevsky, I. T., Zinevich, T. V., Pisareva, I. V., & Bregadze, V. I. (December 1993). Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes. Molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-Rh C2B9H11] [Poster presentation]. Contact Group Meeting Organic Synthesis NFWO-FNRS, De Haan, Belgium.

Antoine, M. H., Pirotte, B., De Tullio, P., Delarge, J., Herchuelz, A., & Lebrun, P. (20 November 1993). A new and potent activator of ATP-sensitive K+ channels [Poster presentation]. Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Lebrun, P., Antoine, M.-H., Masereel, B., Schynts, M., Fontaine, J., Dupont, L., Herchuelz, A., & Delarge, J. (15 October 1993). 3-(Alkylamino)-4h-Pyrido[4,3-E]-1,2,4-Thiadiazine 1,1-Dioxides as Powerful Inhibitors of Insulin Release from Rat Pancreatic B-Cells: A New Class of Potassium Channel Openers? Journal of Medicinal Chemistry, 36 (21), 3211-3213. doi:10.1021/jm00073a025
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Lebrun, P., Pirotte, B., Antoine, M. H., De Tullio, P., Delarge, J., & Herchuelz, A. (September 1993). BPDZ 44 : a new and potent activator of ATP-sensitive K+ channels [Poster presentation]. EASD 29th annual meeting, Istanbul, Turkey.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (August 1993). Comparative structural and stereoelectronical study of pinacidil, diazoxide and cromakalim, potassium channel openers belonging to three different chemical classes [Poster presentation]. IUCr XVI, Beijing, China.

Fontaine, M., Demonceau, A., Noels, A. F., Felekidis, A., Pirotte, B., Delarge, J., Chizhevsky, I. T., Zinevich, T. V., Pisareva, I. V., & Bregadze, V. I. (July 1993). Stereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes [Poster presentation]. Fifth International Conference on the Chemistry of the Platinum Group Metals, United Kingdom.

Jiang, K. Y., Schynts, M., Fesquet, S., Boggetto, N., Masereel, B., Pirotte, B., Delarge, J., & Reboud-Ravaux, M. (June 1993). New inhibitors of serine proteinases [Poster presentation]. Communication à l'Ambassade de Chine à Paris, Paris, France.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (May 1993). Etude structurale comparative du pinacidil, du diazoxide et du cromakalim, ouvreurs de canaux potassiques appartenant à trois classes chimiques distinctes [Poster presentation]. 7èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Fesquet, S., Schynts, M., Boggetto, N., Masereel, B., Pirotte, B., Delarge, J., Jiang, K. Y., & Reboud-Ravaux, M. (May 1993). Un nouvel inhibiteur coumarinique inactive les protéases de specificité chymotrypsique (cathepsine G et chymotrypsine) mais pas l'élastase leucocytaire humaine [Poster presentation]. 7èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Masereel, B., Schynts, M., Pirotte, B., & Delarge, J. (March 1993). Loop diuretics and the renal Na+K+2Cl- cotransport: interaction model [Paper presentation]. Quatrième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Pirotte, B. (March 1993). Improved pancreatic K-ATP channel openers belonging to the pyridothiadiazine chemical class [Paper presentation]. Quatrième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Pirotte, B., Felekidis, A., Fontaine, M., Demonceau, A., Noels, A., Delarge, J., Chizhevsky, I. T., Zinevich, T. V., Pisareva, I. V., & Bregadze, V. I. (1993). Stereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes. Tetrahedron Letters, 34, 1471-1474. doi:10.1016/S0040-4039(00)60321-0
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Masereel, B., Schynts, M., Pirotte, B., & Delarge, J. (1993). Loop diuretics and the renal Na+K+2Cl- cotransport: interaction model. Journal de Pharmacie de Belgique, 48, 141.
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Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., Delarge, J., DUPONT, L., & THUNUS, L. (1993). 4-Acylamino-4H-1,2,4-triazoles and related structures: new investigations of their chemical and physicochemical properties associated to their particular exocyclic amide function. Canadian Journal of Chemistry, 71, 1857-1866. doi:10.1139/v93-233
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Lebrun, P., Pirotte, B., Antoine, M.-H., De Tullio, P., Delarge, J., & Herchuelz, A. (1993). BPDZ 44: a new and potent activator of ATP-sensitive K+ channels. Diabetologia, 36, 406.
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Vilain, A. C., Pirotte, B., Vergely, I., Boggetto, N., Masereel, B., Schynts, M., Delarge, J., & Reboud-Ravaux, M. (1993). Evaluation of the inhibitory activity on serine and aspartic proteases of 4-amino-4H-1,2,4-triazole and 5-aminothiazole derivatives structurally related to β-lactam antibiotics. Journal of Pharmacy and Pharmacology, 45, 466-472. doi:10.1111/j.2042-7158.1993.tb05577.x
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Pirotte, B., Dupont, L., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (1993). Structural study of pinacidil, a potassium channel opener belonging to the chemical class of N-alkyl-N"-cyano-N'-pyridylguanidines. Helvetica Chimica Acta, 76, 1311-1318. doi:10.1002/hlca.19930760318
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Masereel, B., Schynts, M., Krzesinski, J.-M., Pirotte, B., Rorive, G., & Delarge, J. (1993). A sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties. Journal of Pharmacy and Pharmacology, 45, 720-724. doi:10.1111/j.2042-7158.1993.tb07096.x
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Pirotte, B., De Tullio, P., Lebrun, P., Antoine, M.-H., Masereel, B., Schynts, M., & Delarge, J. (1993). Improved pancreatic K-ATP channel openers belonging to the pyridothiadiazine chemical class. Journal de Pharmacie de Belgique, 48, 143.
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Schynts, M., Boggetto, N., Masereel, B., Pirotte, B., Fesquet, S., Vergely, I., Delarge, J., & Reboud-Ravaux, M. (06 November 1992). New dihydrocoumarine derivatives as potential mechanism-based inactivators of serine proteinases [Poster presentation]. Enzyme Inhibition and Drug Discovery, Anvers, Belgium.

Fontaine, M., Demonceau, A., Noëls, A. F., Felekidis, A., Pirotte, B., Delarge, J., Chizhevsky, I. T., Zinevich, T. V., Pisareva, I. V., & Bregadze, V. I. (November 1992). Stereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes [Poster presentation]. Organic Synthesis Meeting, De Haan, Belgium.

Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (July 1992). synthesis of sulfonylthioureas related to torasemide as new "high ceiling diuretics [Poster presentation]. XXXVIIIèmes Rencontres Internationales de Chimie Thérapeutique, Toulouse, France.

Felekidis, A., Pirotte, B., & Demonceau, A. (08 May 1992). Application of high performance liquid chromatography to the determination of the optimized reaction conditions giving stereoselective hydrogenation of methacycline to doxycycline [Poster presentation]. 4th international symposium on drug analysis, Liège, Belgium.

Masereel, B., Lohrmann, E., Schynts, M., Pirotte, B., Greger, R., & Delarge, J. (1992). Design, Synthesis and Biological Activity of a Series of Torasemide Derivatives, Potent Blockers of the Na+ 2cl- K+ Co-Transporter: In-Vitro Study. Journal of Pharmacy and Pharmacology, 44, 589-593. doi:10.1111/j.2042-7158.1992.tb05470.x
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Masereel, B., Schynts, M., Lohrmann, E., Pirotte, B., Greger, R., & Delarge, J. (1992). New relative K+-sparing high ceiling diuretics related to torasemide [Paper presentation]. Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Parmentier, M., Masereel, B., Schynts, M., & Delarge, J. (1992). 3-Oxo-2H,4H-pyrido[2,3-e][1,2,4]-thiadiazine 1,1-dioxide, a sweetening agent of the sulfonamide family structurally related to saccharin and acesulfame. Pharmaceutisch Weekblad, 14, 10.
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Masereel, B., Schynts, M., Lohrmann, E., Pirotte, B., Greger, R., & Delarge, J. (1992). New relative K+-sparing high ceiling diuretics related to torasemide. Journal de Pharmacie de Belgique, 47, 447.
Peer Reviewed verified by ORBi

Lohrmann, E., Masereel, B., Nitschke, R., Pirotte, B., Delarge, J., & Greger, R. (1992). Action of diuretics at the cellular level. In Progress in Pharmacology and Clinical Pharmacology (pp. 23-32). A.J. Reyes, Gustav-Fischer-Verlag.

Pirotte, B., Dive, G., Delarge, J., Masereel, B., Dupont, L., Thunus, L., Schynts, M., Coyette, J., & Frère, J.-M. (1992). Synthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques b-lactamiques. European Journal of Medicinal Chemistry, 27 (3), 193-205. doi:10.1016/0223-5234(92)90003-J
Peer Reviewed verified by ORBi

Masereel, B., Ferrari, P., Ferrandi, M., Pirotte, B., Schynts, M., Parenti, P., & Delarge, J. (1992). Na+,2Cl-,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives. European Journal of Pharmacology, 219, 385-394. doi:10.1016/0014-2999(92)90479-N
Peer Reviewed verified by ORBi

Schynts, M., Boggetto, N., Masereel, B., Pirotte, B., Fesquet, S., Vergely, I., Delarge, J., & Reboud-Ravaux, M. (1992). New dihydrocoumarine derivatives as potential mechanism-based inactivators of serine proteinases. Pharmaceutisch Weekblad, 14, 11.
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Parmentier, M., Masereel, B., Schynts, M., & Delarge, J. (18 October 1991). 3-oxo-2H,4H-pyrido [2,3-e][1,2,4]-thiadiazine 1,1-dioxide, a sweetening agent of the sulfonamide family structurally related to saccharin and acesulfame [Poster presentation]. Receptors signal transduction and drug design, Anvers, Belgium.

Masereel, B., Dupont, L., Lohrmann, E., Schynts, M., Pirotte, B., Greger, R., & Delarge, J. (September 1991). Loop diuretics : SAR, molecular interactions and target topography [Poster presentation]. Réunion commune des sociétés de pharmacie française et allemande, Strasbourg, France.

Masereel, B., Schynts, M., Lorhmann, E., Pirotte, B., Greger, R., & Delarge, J. (September 1991). New relative K+-sparing high ceiling diuretics related to torasemide [Poster presentation]. Cinquièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Boggetto, N., Vilan, A. C., Pirotte, B., Masereel, B., Vergely, I., Dupont, L., Delarge, J., & Reboud-Ravaux, M. (September 1991). 4-Amino-4H-1,2,4-triazole and 5-aminothiazole derivatives structurally related to β-lactam antibiotics as potential inhibitors of serine proteases [Poster presentation]. Réunion commune des sociétés de pharmacie française et allemande, Strasbourg, France.

Felekidis, A., & Pirotte, B. (08 March 1991). Application of high performance liquid chromatography to the evaluation of the stereoselective hydrogenation of 6-demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline [Poster presentation]. Chiralité et Analyse, Bruxelles, Belgium.

Pirotte, B., & Felekidis, A. (March 1991). Evaluation of the stereoselective homogeneous catalytic hydrogenation of methacycline into doxycycline using different zerovalent and monovalent rhodium catalysts [Paper presentation]. Troisième Forum des Sciences Pharmaceutiques, Houffalize, Belgium.

Dupont, L., Dideberg, O., Masereel, B., Delarge, J., Schynts, M., & Pirotte, B. (1991). Structures du cyclohexyl-1[(cycloheptylamino-4 pyridyl-3)sulfonyl]-3 urée et de l'hydrogénonitrate du cyclohexyl-1[(cyclooctylamino-4 pyridyl-3)sulfonyl]-3 urée. Acta Crystallographica, C47, 2152-2156.
Peer Reviewed verified by ORBi

Pirotte, B., Vilain, A.-C., Vergely, I., Boggetto, N., Masereel, B., Dupont, L., Delarge, J., & Reboud-Ravaux, M. (1991). Inhibiteurs potentiels de proteases à sérine apparentés aux antibiotiques β-lactamiques. Regard sur la Biochimie, 6, 91, 12.
Peer reviewed

Lohrmann, E., Nitschke, R. B., Nitschke, R., Burhoff, I., Masereel, B., Pirotte, B., Schlatter, E., Delarge, J., Lang, H. J., Englert, H. C., Salomonsson, M., Persson, A. E. G., Eidelman, O., Cabantchik, Z. I., & Greger, R. (1991). The mode of action of diuretics. In Proc. XIth Int. Congr. Nephrol. Tokyo (pp. 1072-1081). Springer-Verlag, Tokyo.

Dupont, L., Englebert, S., Dideberg, O., Pirotte, B., & Delarge, J. (1991). Structure de l'acide (tert-butylamino-4 oxo-5 triazol-1,2,4 yle-1)acétique. Acta Crystallographica, C47, 1557-1559. doi:10.1107/S0108270191001142
Peer Reviewed verified by ORBi

Boggetto, N., Vilain, A. C., Pirotte, B., Masereel, B., Vergely, I., Dupont, L., Delarge, J., & Reboud-Ravaux, M. (1991). 4-Amino-4H-1,2,4-triazole and 5-aminothiazole derivatives structurally related to β-lactam antibiotics as potential inhibitors of serine proteases. Archiv der Pharmazie, 324, 658.
Peer reviewed

Dupont, L., Englebert, S., Dideberg, O., Pirotte, B., & Delarge, J. (1991). Structure de la bétaïne du carboxyméthyl-1 méthylamino-4 triazolium-1,2,4. Acta Crystallographica, C47, 1756-1758. doi:10.1107/S0108270191000185
Peer Reviewed verified by ORBi

Masereel, B., Dupont, L., Lohrmann, E., Schynts, M., Pirotte, B., Greger, R., & Delarge, J. (1991). Loop diuretics : SAR, molecular interactions and target topography. Archiv der Pharmazie, 324, 650.
Peer reviewed

Pirotte, B., Delarge, J., Coyette, J., & Frère, J.-M. (1991). Antibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to β-lactam antibiotics. Journal of Antibiotics, 44, 844-853. doi:10.7164/antibiotics.44.844
Peer Reviewed verified by ORBi

Dupont, L., Englebert, S., Dideberg, O., Pirotte, B., & Delarge, J. (1991). Structure du [4-phénylacétylimino-1-(1,2,4-triazolio)]acétate de sodium dihydrate. Acta Crystallographica, C47, 1079-1081. doi:10.1107/S0108270190012148
Peer Reviewed verified by ORBi

Felekidis, A., & Pirotte, B. (1991). Evaluation of the stereoselective homogeneous catalytic hydrogenation of methacycline into doxycycline using different zerovalent and monovalent rhodium catalysts. Journal de Pharmacie de Belgique, 46, 147.
Peer Reviewed verified by ORBi

Masereel, B., Pirotte, B., Schynts, M., & Delarge, J. (September 1990). New sulfonylurea torasemide derivatives as potential antihypertensive drugs [Poster presentation]. Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Masereel, B., Pirotte, B., Schynts, M., Delarge, J., Lohrmann, R., Nitschke, R., Schlatter, E., & Greger, R. (08 June 1990). Structure-activity relationship (SAR) of new torasemide derivatives on Na-K-2Cl cotransporter in perfused rabbit thick ascending limb (cTAL) of Henle's loop [Poster presentation]. Symposium " Peptides as new leads in drug design ", Tilburg, Netherlands.

Pirotte, B. (March 1990). Synthesis and biological evaluation of 5-aminothiazole and 4-amino-1,2,4-triazole derivatives, potential inhibitors of bacterial serine enzymes [Paper presentation]. Deuxième Forum des Sciences Pharmaceutiques, De Haan, Belgium.

Pirotte, B., & Delarge, J. (February 1990). Synthesis and biological evaluation of 5-aminothiazole and 4-amino- 1,2,4-triazole derivatives, potential inhibitors of bacterial serine enzymes. Journal de Pharmacie de Belgique, 45, 65.
Peer Reviewed verified by ORBi

Pirotte, B., & Delarge, J. (1990). 5-Phenylacetylaminothiazolium salts and their reactions with nucleophiles. Journal of Chemical Research. Synopses, 208-209.
Peer reviewed

Masereel, B., Pirotte, B., Schynts, M., Delarge, J., Lohrmann, R., Nitschke, R., Slatter, R., & Greger, R. (1990). Structure-activity relationship (SAR) of new torasemide derivatives on Na-K-2Cl cotransporter in perfused rabbit thick ascending limb (cTAL) of Henle's loop. Pharmaceutisch Weekblad, 12, 7.
Peer Reviewed verified by ORBi

Masereel, B., Pirotte, B., Schynts, M., Ferrari, P., Thunus, L., & Delarge, J. (1990). New sulfonylurea torasemide derivatives as potential antihypertensive drugs. Journal de Pharmacie de Belgique, 45, 405.
Peer Reviewed verified by ORBi

Pirotte, B., Masereel, B., Schynts, M., & Delarge, J. (1990). Les sulfamidés diurétiques : des origines aux perspectives d'avenir. Chimie Nouvelle, 8, 920-924.
Peer reviewed

Pirotte, B. (1989). Synthèse et évaluation biologique de dérivés de l'amino-5 thiazole et de l'amino-4 triazole-1,2,4, inhibiteurs potentiels de protéases à sérine bactériennes [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/31249

Dupont, L., Dideberg, O., Sbit, M., Pirotte, B., & Delarge, J. (1989). Structure de la bétaïne phénylacétylamino-5 thiazolium acétate-3 2,63 hydrate. Acta Crystallographica, C45, 419-421.
Peer Reviewed verified by ORBi

Dupont, L., Dideberg, O., Pirotte, B., & Delarge, J. (1989). Structure de la bétaïne du carboxyméthyl-1 phénylacétylamino-4 triazolium-1,2,4. Acta Crystallographica, C45, 1928-1930.
Peer Reviewed verified by ORBi

Dupont, L., Dideberg, L., Pirotte, B., & Delarge, J. L. (1989). Structure du bromure de carboxyméthyl-3 thiazolium. Acta Crystallographica, C45, 1926-1928.
Peer Reviewed verified by ORBi

Pirotte, B. (December 1988). Synthèse et évaluation biologique de dérivés de l'amino-4 triazole 1,2,4, inhibiteurs potentiels de protéases à sérine bactériennes [Paper presentation]. Contact Group NFWO-FNRS "Medicinal Chemistry", Bruxelles, Belgium.

Pirotte, B. (October 1987). Recherche d'un nouveau mécanisme d'inhibition de protéases à sérine bactériennes [Poster presentation]. Journées Franco-Belge de Pharmacochimie, Lille, France.

Pirotte, B. (May 1987). Les sels de thiazolium en tant qu'inhibiteurs potentiels d'enzymes à sérine [Paper presentation]. Semaine d'étude de la Chimie organique (SECO XXIV), Gif-sur-Yvette, France.

Pirotte, B., & Jaminet, F. (1984). Etude de la cinétique de libération "in vitro" de la nitroglycérine à partir de quelques systèmes d'administration percutanée. Journal de Pharmacie de Belgique, 39, 125-135.
Peer Reviewed verified by ORBi

Pirotte, B., & Jaminet, F. (1984). Etude de la libération "in vitro" de la nitroglycérine à partir de formulations galéniques destinées à la voie percutanée. Partie II. Journal de Pharmacie de Belgique, 39, 77-87.
Peer Reviewed verified by ORBi

Pirotte, B., & Jaminet, F. (1984). Etude de la libération "in vitro" de la nitroglycérine à partir de formulations galéniques destinées à la voie percutanée. Partie I. Journal de Pharmacie de Belgique, 39, 23-35.
Peer Reviewed verified by ORBi

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