[en] Initial neuropathology of early Alzheimer’s disease accumulates in the transentorhinal cortex. We review empirical data suggesting that tasks assessing cognitive functions supported by the transenthorinal cortex are impaired as early as the preclinical stages of Alzheimer’s disease. These tasks span across various domains, including episodic memory, semantic memory, language, and perception. We propose that all tasks sensitive to Alzheimer-related transentorhinal neuropathology commonly rely on representations of entities supporting the processing and discrimination of items having perceptually and conceptually overlapping features. In the future, we suggest a screening tool that is sensitive and specific to very early Alzheimer’s disease to probe memory and perceptual discrimination of highly similar entities.
Disciplines :
Neurosciences & behavior
Author, co-author :
Bastin, Christine ; Université de Liège - ULiège > Département des sciences cliniques
Delhaye, Emma ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Language :
English
Title :
Targeting the function of the transentorhinal cortex to identify early cognitive markers of Alzheimer’s disease
Publication date :
2023
Journal title :
Cognitive, Affective and Behavioral Neuroscience
ISSN :
1530-7026
eISSN :
1531-135X
Publisher :
Psychonomic Society, United States - Texas
Volume :
23
Pages :
986-996
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] Fondation Recherche Alzheimer [BE] ULiège - Université de Liège [BE]
This work was supported by SAO-FRA (grants S#14003, #2017/0008), by the Alzheimer Association (grant #2016-NIRG-394141), by the University of Liège via Special Funds for Research and by the F.R.S.-FNRS (grant #T0009.19).
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