ORBi: Detailled Reference

Article (Scientific journals)

Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022?

Dispas, Amandine; Sacre, Pierre-Yves; Ziemons, Eric et al.

2022 • In Journal of Pharmaceutical and Biomedical Analysis, 221, p. 115071

Peer Reviewed verified by ORBi Dataset

Permalink
https://hdl.handle.net/2268/295387

DOI
10.1016/j.jpba.2022.115071

PubMed
36179505

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

2022_review_JPBA_AD.pdf

Publisher postprint (2.08 MB)

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Multidimensional chromatography; NIR spectroscopy; Pharmaceuticals; Quality control; Raman spectroscopy; Supercritical fluid chromatography; Vibrational spectroscopy

Abstract :

[en] Quality control is a fundamental and critical activity in the pharmaceutical industry that guarantees the quality of medicines. QC analyses are currently performed using several well-known techniques, mainly liquid and gas chromatography. However, current trends are focused on the development of new techniques to reduce analysis time and cost, to improve the performances and decrease ecological footprint. In this context, analytical scientists developed and studied emerging technologies based on spectroscopy and chromatography. The present review aims to give an overview of the recent development of vibrational spectroscopy, supercritical fluid chromatography and multi-dimensional chromatography. Selected emerging techniques are discussed using SWOT analysis and published pharmaceutical QC applications are discussed.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Chemistry
Pharmacy, pharmacology & toxicology

Author, co-author :

Dispas, Amandine ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Sacre, Pierre-Yves ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Language :

English

Title :

Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022?

Publication date :

22 September 2022

Journal title :

Journal of Pharmaceutical and Biomedical Analysis

ISSN :

0731-7085

eISSN :

1873-264X

Publisher :

Elsevier BV, England

Volume :

221

Pages :

115071

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0731708522004927?httpAccept=text/xml

Data Set :

https://doi.org/10.1016/j.jpba.2022.115071

Available on ORBi :

since 03 October 2022

Statistics

Number of views

122 (7 by ULiège)

Number of downloads

13 (2 by ULiège)

More statistics

Scopus citations^®

9

Scopus citations^®
without self-citations

9

OpenCitations

1

OpenAlex citations

10

Bibliography

Eudralex – Volume 4 – Good Manufacturing Practice (GMP) guidelines 〈https://ec.europa.eu/health/documents/eudralex/vol-4_en〉.
Mattrey, F.T., Makarov, A.A., Regalado, E.L., Bernardoni, F., Figus, M., Hicks, M.B., Zheng, J., Wang, L., Schafer, W., Antonucci, V., Hamilton, S.E., Zawatzky, K., Welch, C.J., Current challenges and future prospects in chromatographic method development for pharmaceutical research. TrAC Trends Anal. Chem. 95 (2017), 36–46, 10.1016/j.trac.2017.07.021.
Bertrand, D., Dufour, E., La Spectroscopie Infrarouge Et Ses Applications Analytiques, second ed., 2006, Lavoisier, Paris.
Burns, D.A., Ciurczak, E.W., Handbook of Near‐Infrared Analysis, third ed., 2008, CRC Press, New York.
Reich, G., Near-Infrared spectroscopy and imaging: basic principles and pharmaceutical applications. Adv. Drug Deliv. Rev. 57 (2005), 1109–1143, 10.1016/j.addr.2005.01.020.
Deidda, R., Sacre, P.-Y., Clavaud, M., Coic, L., Avohou, H., Hubert, P., Ziemons, E., Vibrational spectroscopy in analysis of pharmaceuticals: critical review of innovative portable and handheld NIR and Raman spectrophotometers. TrAC Trends Anal. Chem. 114 (2019), 251–259, 10.1016/j.trac.2019.02.035.
De Bleye, C., Chavez, P.-F., Mantanus, J., Marini, R., Hubert, Ph, Rozet, E., Ziemons, E., Critical review of near-infrared spectroscopic methods validations in pharmaceutical applications. J. Pharm. Biomed. Anal. 69 (2012), 125–132, 10.1016/j.jpba.2012.02.003.
Wise, B.M., Roginski, R.T., A calibration model maintenance roadmap. IFAC 48 (2015), 260–265, 10.1016/j.ifacol.2015.08.191.
Sasic, S., Pharmaceutical Applications of Raman Spectroscopy. 2007, John Wiley & Sons, New Jersey.
de Veij, M., Vandenabeele, P., De Beer, T., Remon, J.P., Moens, L., J.Raman Spectrosc., 40, 2009, 297.
A. Silge, K. Weber, D. Cialla-May, L. Muller-Botticher, D. Fischer, J. Popp, Trends in pharmaceutical analysis and quality control by modern Raman spectrosocopic techniques, TrAC Trends in Analytical Chemistry 116623 in press https://doi.org/10.1016/j.trac.2022.116623.
Roy, S., Chamberlain, B., Matzger, A.J., Polymorph discrimination using low wavenumber Raman spectroscopy. Org. Process Res. Dev. 17 (2013), 976–980, 10.1021/op400102e.
Zhang, Y., Zhao, S., Zheng, J., He, L., Surface-enhanced Raman spectroscopy (SERS) combined techniques for high-performance detection and characterization. TrAC Trends Anal. Chem. 90 (2017), 1–13, 10.1016/j.trac.2017.02.006.
Brouckaert, D., Vandenbroucke, F., Chauchard, F., Dollinger, M., Roggo, Y., Pellegatti, L., Krumme, M., Towards real-time release of pharmaceuticals tablets: 100 % in-line control via near-infratred spatially resolved spectroscopy and 3D-microwave technology. J. Pharm. Biomed. Anal., 209, 2022, 114491.
Verstraeten, M., Van Hauwermeiren, D., Hellings, M., Hermans, E., Geens, J., Vervaet, C., Nopens, I., De Beer, T., Model-base NIR spectroscopy implementation for in-line assay monitoring during a pharmaceutical suspension manufacturing process. Int. J. Pham, 546, 2018, 10.1016/j.ijpharm.2018.05.043 347-254.
Andrews, G.P., Jones, D.S., Senta-Loys, Z., Almajaan, A., Li, S., Chevallier, O., Elliot, C., Healy, A.M., Kelleher, J.F., Madi, A.M., Gilvary, G.C., Tian, Y., The development of an inline Raman spectroscopic analysis method as quality control tool for hot melt extruded ramipril fixed-dose combination products. Int. J. Pharm. 566 (2019), 476–487 〈https://doi.orf/j.ijpharm.2019.05.029〉.
Ciza, P.H., Sacré, P.Y., Waffo, C., Coic, L., Avohou, H., Mbinze, J.K., Ngono, R., Marini, R.D., Hubert, Ph, Ziemons, E., Comparing the qualitative performances of handheld NIR and Raman spectrophotometers for the detection of falsidied pharmaceutical products. Talanta 202 (2019), 469–478, 10.1016/j.talanta.2019.04.049.
Omar, J., Ulberth, F., Raman spectroscopy for quality control and detection of substandard painkillers. Vib. Spec., 111, 2020, 103147, 10.1016/j.vibspec.2020.103147.
Pino-Torres, C., Maspoch, S., Castillo-Felices, R., Perez-Rivera, M., Aranda-Bustos, M., Pena-Farfal, C., Evaluation of NIR and Raman spectroscopies for the quality analytical control of a solid pharmaceutical formulation with three active ingredients. Microchem. J., 154, 2020, 104576, 10.1016/j.microc.2019.104576.
Esbensen, K.H., Geladi, P., Principles of proper validation: use and abuse of re-sampling for validation. J. Chemom. 24 (2010), 168–187, 10.1002/cem.1310.
Fekadu Belay, N., Busche, S., Manici, V., Shaukat, M., Arndt, S.-O., Schmidt, C., Evaluation of Transmission Raman spectroscopy and NIR hyperspectral imaging fot the assessment of content uniformity in solid oral dosage forms. Eur. J. Pharm. Sci., 166, 2021, 105963, 10.1016/j.eps.2021.105963.
Minh Mai Lê, L., Berge, M., Tfayli, A., Shou, J., Prognon, P., Bailler-Guffroy, A., Caudron, E., Rapid discrimination and quantification analysis of fiva antineoplastic drugs in aqueous solution using Raman spectroscopy. Eur. J. Pharm. Sci. 111 (2018), 158–166, 10.1016/j.ejps.2017.09.046.
Hubert, Ph, Nguyen-Huu, J.J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., Valat, L., Harmonization of strategies for the validation of quantitative analytical procedures – A SFSTP proposal – part I. J. Pharm. Biomed. Anal. 36 (2004), 579–586, 10.1016/j.jpba.2004.07.027.
Hubert, Ph, Nguyen-Huu, J.J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., Valat, L., Rozet, E., Harmonization of strategies for the validation of quantitative analytical procedures – A SFSTP proposal – part II. J. Pharm. Biomed. Anal. 45 (2007), 70–81, 10.1016/j.jpba.2007.06.013.
Hubert, Ph, Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., Valat, L., Rozet, E., Harmonization of strategies for the validation of quantitative analytical procedures – A SFSTP proposal – part III. J. Pharm. Biomed. Anal. 45 (2007), 82–96, 10.1016/j.jpba.2007.06.032.
Hubert, Ph, Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., Valat, L., Rozet, E., Harmonization of strategies for the validation of quantitative analytical procedures – A SFSTP proposal – part IV. J. Pharm. Biomed. Anal. 48 (2008), 760–771, 10.1016/j.jpba.2008.07.018.
ICH Q2 (R1), Validation of analytical procedures: text and methodology, 2005.
USP chapter 1210, Statistical tools for method validation.
ICH Q2 (R2), Validation of analytical procedures: text and methodology, under revision.
Fearn, T., Standardisation and calibration transfer for near infrared instruments: a review. J. Infrared Spectrosc. 9 (2001), 229–244, 10.1255/jnirs.309.
Workman, J.J., A review of calibration transfer practices and instrument differences in spectroscopy. Appl. Spectrosc. 72 (2018), 340–365, 10.1177/0003702817736064.
Ciza, P.H., Sacré, P.Y., Waffo, C., Kimbeni, T.M., Masereel, B., Hubert, Ph, Ziemons, E., Marini, R.D., Comparison of several strategies for the deployment of a multivariate regression model of several handheld NIR instruments. Applications to the quality control of medicines. J. Pharm. Biomed. Anal., 215, 2022, 114755, 10.1016/j.jpba.2022.114755.
Hugo da Silva, V., José da Silva, J., Fernandes Pereira, C., Portable near-infrared instruments: application for quality control of polymorphs in pharmaceutical raw material and calibration transfer. J. Pharm. Biomed. Anal. 143 (2017), 287–294, 10.1016/j.jpba.11.036.
Mark, D., Xarman, M., Dumarey, M., Bergman, E.-L., Folestad, S., Shi, Z., Manley, L.F., Goodwin, D.J., Zeitler, J.A., Review of real-time release testing of pharmaceutical tablets: state-of-the art, challenges and future perspective. Int. J. Pharm., 582, 2020, 119353, 10.1016/j.ijpharm.2020.119353.
Chavez, P.-F., Stauffer, F., Eeckman, F., Bostijn, N., Didion, D., Schaefer, C., Yang, H., El Aalamat, Y., Lories, X., Warman, M., Mathieu, B., Mantanus, J., Control stratefy definition for a drug product continuous wet granulation process: industrial case study. Int. J. Pharm., 624, 2022, 121970, 10.1016/j.ijpharm.2022.121970.
Tarafder, A., Metamorphosis of supercritical fluid chromatography to SFC: an overview. TrAC - Trends Anal. Chem. 81 (2016), 3–10, 10.1016/j.trac.2016.01.002.
Losacco, G.L., Veuthey, J.L., Guillarme, D., Supercritical fluid chromatography – Mass spectrometry: Recent evolution and current trends. TrAC - Trends Anal. Chem. 118 (2019), 731–738, 10.1016/j.trac.2019.07.005.
Losacco, G.L., Veuthey, J.-L., Guillarme, D., Metamorphosis of supercritical fluid chromatography: a viable tool for the analysis of polar compounds?. TrAC Trends Anal. Chem., 141, 2021, 116304, 10.1016/j.trac.2021.116304.
Berger, T.A., Evolution of Instrumentation for Analytical Scale Supercritical Fluid Chromatography. Supercritical Fluid Chromatography, 2017, Elsevier, 173–212, 10.1016/B978-0-12-809207-1.00007-0.
Fornstedt, T., Enmark, M., Samuelsson, J., Method transfer in SFC from a fundamental perspective. TrAC Trends Anal. Chem., 149, 2022, 116551, 10.1016/j.trac.2021.116551.
Gazarkova, T., Plachka, K., Svec, F., Novakova, L., Current state of supercritical fluid chromatography-mass spectrometry. TrAC Trends Anal. Chem., 149, 2022, 116544, 10.1016/j.trac.2022.116544.
Broeckhoven, K., Advances in the limits of separation power in supercritical fluid chromatography. TrAC Trends Anal. Chem., 146, 2022, 116489, 10.1016/j.trac.2021.116489.
Jambo, H., Hubert, Ph, Dispas, A., Supercritical fluid chromatography for pharmaceutical quality control: current challenges and perspectives., 146, 2022, 116486, 10.1016/j.trac.2021.116486.
Novakova, L., Dousa, M., General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography. Anal. Chim. Acta 950 (2017), 199–210, 10.1016/j.aca.2016.11.002.
La, Z., Charton, J., Etienne, L., Bourey, J., Lipka, E., Supercritical fluid chromatography and liquid chromatography for isomeric separation of a multiple chiral centers analyte. J. Chromatogr. A, 1651, 2021, 462270, 10.1016/j.chroma.2021.462270.
Barhate, C.L., Lopez, D.A., Makarov, A.A., Bu, X., Morris, W.J., Lekhal, A., Hartman, R., Armstrong, D.W., Regalado, E.L., Macrocyclic glycopeptide chiral selectors bonded to core-shell particles enables enantiopurity analysis of the entire verubecestat synthetic route. J. Chromatogr. A 1539 (2018), 87–92, 10.1016/j.chroma.2018.01.042.
Schmidtsdorff, S., Schmidt, A.H., Simultaneous detection of nitrosamines and other sartan-related impurities in active pharmaceutical ingredients by supercritical fluid chromatography. J. Pharm. Biomed. Anal. 174 (2019), 151–160, 10.1016/j.jpba.2019.04.049.
Schmidtsdorff, S., Neumann, J., Schmidt, A.H., Parr, M.K., Analytical lifecycle management for comprehensive and universal nitrosamine analysis in various pharmaceutical formulations by supercritical fluid chromatography. J. Pharm. Biomed. Anal., 197, 2021, 113960, 10.1016/j.jpba.2021.113960.
Foulon, C., Di Giulio, P., Lecoeur, M., Simultaneous determination of inorganic anions and cations by supercritical fluid chromatography using evaporative light scattering detection. J. Chromatogr. A 1534 (2018), 139–149, 10.1016/j.chroma.2017.12.047.
Bouchot, P., Foulon, C., Lecoeur, M., Determination of the stoichiometry between a drug and its counter-ion by supercritical fluid chromatography using ultra-violet and evaporative light scattering detections: application to ondansetron hydrochloride. Talanta, 218, 2020, 121166, 10.1016/j.talanta.2020.121166.
Wolrab, D., Fruhauf, P., Kolderova, N., Kohout, M., Strong cation- and zwitterion-exchange-type mixed-mode stationary phases for separation of pharmaceuticals and biogenic amines in different chromatographic modes. J. Chromatogr. A, 1635, 2021, 461751, 10.1016/j.chroma.2020.461751.
Molineau, J., Hideux, M., West, C., Chromatographic analysis of biomolecules with pressurized carbon dioxide mobile phases – a review. J. Pharm. Biomed. Anal., 193, 2020, 113736, 10.1016/j.jpba.2020.113736.
Tanaka, S., Uchiyama, N., Goda, T., Lida, T., Horie, S., Masada, S., Arai, R., Yamamoto, E., Hakamatsuka, T., Okuda, H., Goda, Y., A simple and rapid method to simultaneously analyse ciclesonide and its impurities in a ciclesonide metered-dose inhaler using on-line supercritical fluid extraction/supercritical fluid chromatography/quadrupole time-of-flight mass spectrometry. J. Pharm. Biomed. Anal., 204, 2021, 114253.
Plachká, K., Khalikova, M., Babičová, B., Němcová, Z., Roubíčková, L., Svec, F., Nováková, L., Ultra-high performance supercritical fluid chromatography in impurity control II: method validation. Anal. Chim. Acta 1117 (2020), 48–59, 10.1016/j.aca.2020.04.038.
Dispas, A., Desfontaine, V., Andri, B., Lebrun, P., Kotoni, D., Clarke, A., Guillarme, D., Hubert, P., Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. J. Pharm. Biomed. Anal. 134 (2017), 170–180, 10.1016/j.jpba.2016.11.039.
Dispas, A., Marini, R., Desfontaine, V., Veuthey, J.-L., Kotoni, D., Gioacchino Losacco, L., Clarke, A., Muscat Galea, C., Mangelings, D., Jocher, B.M., Regalado, E.L., Plachká, K., Nováková, L., Wuyts, B., Franç ois, I., Gray, M., Aubin, A.J., Tarafder, A., Cazes, M., Desvignes, C., Villemet, L., Sarrut, M., Raimbault, A., Lemasson, E., Lesellier, E., West, C., Leek, T., Wong, M., Dai, L., Zhang, K., Grand-Guillaume Perrenoud, A., Brunelli, C., Hennig, P., Bertin, S., Mauge, F., Da Costa, N., Farrell, W.P., Hill, M., Desphande, N., Grangrade, M., Sadaphule, S., Yadav, R., Rane, S., Shringare, S., Iguiniz, M., Heinisch, S., Lefevre, J., Corbel, E., Roques, N., Vander Heyden, Y., Guillarme, D., Hubert, P., First inter-laboratory study of a supercritical fluid chromatography method for the determination of pharmaceutical impurities. J. Pharm. Biomed. Anal. 161 (2018), 414–424, 10.1016/j.jpba.2018.08.042.
Dispas, A., Clarke, A., Perrenoud, A.G.-G., Losacco, L.G., Veuthey, J.-L., Gros, Q., Molineau, J., Noireau, A., West, C., Salafia, F., Zoccali, M., Mondello, L., Guillen, A., Wang, J., Zhang, K., Jochems, P., Schad, G., Nakajima, K., Horie, S., Joseph, J., Parr, M.K., Billemont, P., Severino, A., Schneider, S., Naegele, E., Kutscher, D., Wikfors, R., Black, R., Ingvaldson, L., Da Silva, J.O., Bennett, R., Regalado, E.L., Hoang, T.P.T., Touboul, D., Nikolova, Y., Kamenova-Nacheva, M., Dimitrov, V., Berger, B.K., Schug, K.A., Kerviel-Guillon, S., Mauge, F., Takahashi, M., Izumi, Y., Bamba, T., Rouvière, F., Heinisch, S., Guillarme, D., Hubert, P., Interlaboratory study of a supercritical fluid chromatography method for the determination of pharmaceutical impurities: evaluation of multi-systems reproducibility. J. Pharm. Biomed. Anal., 2021, 114206, 10.1016/j.jpba.2021.114206.
Giddings, J.C., Concepts and comparisons in multidimensional separation. J. High. Resolut. Chromatogr. 10 (1987), 319–323, 10.1002/jhrc.1240100517.
Zhang, K., Wang, J., Tsang, M., Wigman, L., Chetwyn, N., Two-dimensional HPLC in pharmaceutical analysis. Am. Pharm. Rev. 16 (2013), 39–44.
Mondello, L., Lewis, A.C., Bartle, K.D., Multidimensional Chromatography. 2002, Wiley, West Sussex, England, NewYork.
Iguiniz, M., Heinisch, S., Two-dimensional liquid chromatography in pharmaceutical analysis. Instrumental aspects, trends and applications. J. Pharm. Biomed. Anal. 145 (2017), 482–503, 10.1016/j.jpba.2017.07.009.
Burlet-Parendel, M., Faure, K., Opportunities and challenges of liquid chromatography coupled to supercritical fluid chromatography. TrAC, 144, 2021, 116422.
Iguiniz, M., Rouvière, F., Corbel, E., Roques, N., Heinisch, S., Comprehensive two-dimensional liquid chromatography as analytical strategy for pharmaceutical analysis. J. Chromatogr. A 1536 (2018), 195–204, 10.1016/j.chroma.2017.08.070.
Wang, H., Herderschee, H.R., Bennett, R., Potapenko, M., Pickens, C.J., Mann, B.F., Haidar Ahmad, I.A., Regalado, E.L., Introducing online multicolumn two-dimensional liquid chromatography screening for facile selection of stationary and mobile phase conditions in both dimensions. J. Chromatogr. A, 1622, 2020, 460895, 10.1016/j.chroma.2020.460895.
Wicht, K., Baert, M., Kajtazi, A., Schipperges, S., Von Doehren, N., Desmet, G., De Villiers, A., Lynen, F., Pharmaceutical impurity analysis by comprehensive two-dimensional temperature responsive × reversed phase liquid chromatography. J. Chromatogr. A, 1630, 2020, 461561, 10.1016/j.chroma/2020.461561.
Goyon, A., Scott, B., Crittenden, C.M., Zhang, K., Analysis of pharmaceutical drug oligomers by selective comprehensive two-dimensional liquid chromatography-high resolution mass spectrometry. J. Pharm. Biomed. Anal., 208, 2022, 114466, 10.1016/j.Jpba.2021.114466.
Li, F., Lammerhofer, M., Impurity profiling of siRNA by two-dimensional liquid chromatography-mass spectrometry with quinine carbamate anion-exchanger and ion-pair reversed-phase chromatography. J. Chromatogr. A, 1643, 2021, 462065, 10.1016/j.chroma.2021.462065.
Li, F., Su, X., Baurer, S., Lammerhofer, M., Multiple heart-cutting mixed-mode chromatography-reversed-phase 2D-liquid chromatography method for separation and mass spectrometric characterization of synthetic oliogonucleotides. J. Chromatogr. A, 1625, 2020, 461338, 10.1016/j.chroma.2020.461338.
Karongo, R., Ikegami, T., Stoll, D.R., Lammerhofer, M., A selective comprehensive reversed phase × reverse phase 2D-liquid chromatography approach with multiple complementary detectors as advanced generic method for the quality control of synthetic and therapeutic peptides. J. Chromatogr. A, 1627, 2020, 461430, 10.1016/j.chroma.2020.461630.
Iguiniz, M., Corbel, E., Roques, N., Heinisch, S., Quantitative aspects in on-line comprehensive two-dimensional liquid chromatography for pharmaceutical applications. Talanta 195 (2019), 272–280, 10.1016/j.talanta.2018.11.030.
Yang, S.H., Wang, J., Zhang, K., Validation of two-dimensional liquid chromatography method for quality control testing of pharmaceutical materials. J. Chromatogr. A 1492 (2017), 89–97, 10.1016/j.chroma.2017.02.074.
Venkatramani, C.J., Al-Sayah, M., Li, G., Goel, M., Girotti, J., Zang, L., Wigman, L., Yehl, P., Chetwyn, N., Simultaneous achiral-chiral analysis of pharmaceutical compounds using two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography. Talanta 148 (2016), 548–555, 10.1016/j.talanta.2015.10.054.
Iguiniz, M., Corbel, E., Roques, N., Heinisch, S., On-line coupling of achiral reversed phase liquid chromatography and chiral supercritical fluid chromatography for the analysis of pharmaceutical compounds. J. Pharm. Biomed. Anal. 159 (2018), 237–244, 10.1016/j.jpba.2018.06.058.
Crépier, J., Corbel, E., Lerestif, J.-M., Berthod, A., Characterization of positional isomers of drug intermediates by off-line RPLC × SFC hyphenated to high resolution MS. J. Pharm. Biomed. Anal., 202, 2021, 114142, 10.1016/j.jpba.2021.114142.
Zeng, L., Xu, R., Zhang, Y., Kassel, D.B., Two-dimensional supercritical fluid chromatography/mass spectrometry for the enantiomeric analysis and purification of pharmaceutical. J. Chromatogr. A, 2011, 10.1016/j.chroma.2011.03.041.

Similar publications