Reduced T-cell response following a third dose of SARS-CoV-2 vaccine in infection-naïve people living with HIV

[en] HIGHLIGHTS • People living with HIV show similar humoral immune responses towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals. • People living with HIV with no prior SARS-CoV-2 infection show reduced T-cell response towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals. • Hybrid immunity induces similar T-cell responses between people living with HIV and HIV-negative individuals. The full-text article is available free by clicking the following link: https://www.journalofinfection.com/article/S0163-4453(22)00534-5/fulltext

Disciplines :

Immunology & infectious disease

Author, co-author :

El Moussaoui, Majdouline ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Maladies infectieuses et médecine interne générale

Desmecht, Salomé ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI)

Tashkeev, Aleksandr ; Université de Liège - ULiège > GIGA

Lambert, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie

Maes, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)

Braghini, Joachim

MARECHAL, Nicole ; Centre Hospitalier Universitaire de Liège - CHU > > Département infirmier

Quintana, Céline

BRIQUET, Karine ; Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne

Gofflot, Stéphanie ; Centre Hospitalier Universitaire de Liège - CHU > > Biothèque Hospitalo-Universitaire de Liège (BHUL)

More authors (10 more)

Language :

English

Title :

Reduced T-cell response following a third dose of SARS-CoV-2 vaccine in infection-naïve people living with HIV

Publication date :

05 September 2022

Journal title :

Journal of Infection

ISSN :

0163-4453

eISSN :

1532-2742

Publisher :

Elsevier BV

Volume :

Pages :

751-755

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0163445322005345?httpAccept=text/xml

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Leon Fredericq Foundation

Available on ORBi :

since 11 September 2022

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Bibliography

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Lapointe, H.R., Mwimanzi, F., Cheung, P.K., Sang, Y., Yaseen, F., Umviligihozo, G., et al. People with HIV receiving suppressive antiretroviral therapy show typical antibody durability after dual COVID-19 vaccination, and strong third dose responses. J Infect Dis, 2022, jiac229, 10.1093/infdis/jiac229.
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Antinori, A., Cicalini, S., Meschi, S., Bordoni, V., Lorenzini, P., Vergori, A., et al. Humoral and cellular immune response elicited by mRNA vaccination against SARS-CoV-2 in people living with HIV (PLWH) receiving antiretroviral therapy (ART) according with current CD4 T-lymphocyte count [published online ahead of print, 2022 Apr 2]. Clin Infect Dis, 2022, ciac238, 10.1093/cid/ciac238.
Brumme, Z.L., Mwimanzi, F., Lapointe, H.R., Cheung, P.K., Sang, Y., Duncan, M.C., et al. Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy. NPJ Vaccines, 7, 2022, 28, 10.1038/s41541-022-00452-6.
Rodda, L.B., Morawski, P.A., Pruner, K.B., Fahning, M.L., Howard, C.A., Franko, N., et al. Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity. Cell 185:9 (2022), 1588–1601, 10.1016/j.cell.2022.03.018 e14.
Evans, J.P., Zeng, C., Carlin, C., Lozanski, G., Saif, L.J., Oltz, E.M., et al. Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection. Sci Transl Med, 14(637), 2022, eabn8057, 10.1126/scitranslmed.abn805710.
Ogbe, A., Pace, M., Bittaye, M., Tipoe, T., Adele, S., Alagaratnam, J., et al. Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV. JCI Insight, 7(7), 2022, e157031, 10.1172/jci.insight.157031.

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