Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

Carcinoma, Squamous Cell/immunology/metabolism/pathology/virology; Cell Transformation, Viral/immunology; Cervix Uteri/immunology/metabolism/pathology/virology; Female; Gene Expression Regulation, Viral; Gonadal Steroid Hormones/metabolism; Humans; Metaplasia; Tumor Virus Infections/immunology/metabolism/pathology; Uterine Cervical Neoplasms/immunology/metabolism/pathology/virology

Abstract :

[en] If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.

Disciplines :

Endocrinology, metabolism & nutrition
Oncology

Author, co-author :

Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Herman, Ludivine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Kholod, Natalia

Caberg, Jean-Hubert ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

Herfs, Michael ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Boniver, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Jacobs, Nathalie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Hubert, Pascale ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Language :

English

Title :

Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

Publication date :

2007

Journal title :

Molecular and Cellular Endocrinology

ISSN :

0303-7207

eISSN :

1872-8057

Publisher :

North Holland Publishing Company, Amsterdam, Netherlands

Volume :

264

Issue :

1-2

Pages :

1-5

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

IAP (interuniversityattractionpole) network(P5/31)
Centre de Recherches Interuniversitaires en Vaccinologie GSK and WalloonRegion
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Fonds Léon Fredericq

Available on ORBi :

since 23 October 2009

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