[en] Recent years have been the stage to a shift in cannabis policies and trends that have impacted cannabis usage and public perception. On the other hand, there has also been a rise in the development and distribution of synthetic cannabinoids which are synthetic compounds that also act on the endocannabinoid receptors. They are mostly used as recreational drugs and because their potency and toxicity are not always known, they can lead to severe adverse effects after consumption. The detection of cannabis counterfeiting with synthetic cannabinoids is essential to produce safe cannabis-based medicines and we aimed to develop a generic supercritical fluid chromatography hyphenated to mass spectrometry (SFC-MS) method that could help in detecting such adulterations using representative synthetic cannabinoids from multiple classes.
Method development started with a screening of stationary phases using seven different SFC-dedicated columns. Then, an optimization following analytical quality-by-design principles was performed followed by an assessment of the quantitative performances with a validation according to the total-error strategy. This innovative tool should prove useful in the context of counterfeit drugs tracking in the challenges to come.
Research Center/Unit :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Chemistry Pharmacy, pharmacology & toxicology
Author, co-author :
Jambo, Hugues ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Dispas, Amandine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Avohou, Tonakpon Hermane ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
André, Sébastien ; Université de Liège - ULiège > Master sc. pharma., à fin.
Hubert, Cédric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Lebrun, Pierre; Pharmalex
Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Language :
English
Title :
SFC-MS for the quality control of cannabis: addressing the potential adulteration with synthetic cannabinoids
Publication date :
19 December 2018
Event name :
CIRM Day (1st edition)
Event date :
19 Décembre 2018
Name of the research project :
FEDER Projet PHARE Projet Vibra4fake
Funders :
FEDER - Fonds Européen de Développement Régional [BE] Région wallonne [BE] Fonds Léon Fredericq [BE]