Reference : SFC-MS for the quality control of cannabis: addressing the potential adulteration wit...
Scientific conferences in universities or research centers : Scientific conference in universities or research centers
Physical, chemical, mathematical & earth Sciences : Chemistry
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/230328
SFC-MS for the quality control of cannabis: addressing the potential adulteration with synthetic cannabinoids
English
Jambo, Hugues mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Dispas, Amandine mailto [Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments >]
Avohou, Tonakpon Hermane mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
André, Sébastien mailto [Université de Liège - ULiège > > > Master sc. pharma., à fin.]
Hubert, Cédric mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Lebrun, Pierre mailto [Pharmalex > > > >]
Ziemons, Eric mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Hubert, Philippe mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
19-Dec-2018
CIRM Day (1st edition)
19 Décembre 2018
[en] SFC-MS ; Cannabis ; Synthetic cannabinoids
[en] Recent years have been the stage to a shift in cannabis policies and trends that have impacted cannabis usage and public perception. On the other hand, there has also been a rise in the development and distribution of synthetic cannabinoids which are synthetic compounds that also act on the endocannabinoid receptors. They are mostly used as recreational drugs and because their potency and toxicity are not always known, they can lead to severe adverse effects after consumption. The detection of cannabis counterfeiting with synthetic cannabinoids is essential to produce safe cannabis-based medicines and we aimed to develop a generic supercritical fluid chromatography hyphenated to mass spectrometry (SFC-MS) method that could help in detecting such adulterations using representative synthetic cannabinoids from multiple classes.
Method development started with a screening of stationary phases using seven different SFC-dedicated columns. Then, an optimization following analytical quality-by-design principles was performed followed by an assessment of the quantitative performances with a validation according to the total-error strategy. This innovative tool should prove useful in the context of counterfeit drugs tracking in the challenges to come.
Centre Interfacultaire de Recherche du Médicament - CIRM
Fonds Européen de Développement Régional - FEDER Projet PHARE ; Région wallone Projet Vibra4fake ; Fonds Léon Fredericq
Researchers ; Professionals
http://hdl.handle.net/2268/230328

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