Profil

Avohou Tonakpon Hermane

See author's contact details
Main Referenced Co-authors
Hubert, Philippe  (41)
Ziemons, Eric  (37)
Sacre, Pierre-Yves  (24)
Lebrun, Pierre  (16)
Hubert, Cédric  (12)
Main Referenced Keywords
Raman spectroscopy (7); Design Space (4); falsified medicines (4); SERS (4); Analytical Chemistry (3);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (28)
Centre Interfacultaire de Recherche du Médicament - CIRM (1)
LCAP, CIRM, ULIEGE (1)
Laboratory of Pharmaceutical Analytical Chemistry - Prof. Philippe Hubert (1)
Laboratory of Pharmaceutical Analytical Chemistry - VibraSanté-Hub - CIRM (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (44)
Chemistry (13)
Mathematics (6)
Laboratory medicine & medical technology (1)
Public health, health care sciences & services (1)

Publications (total 52)

The most downloaded
178 downloads
Deidda, R., Avohou, T. H., Jambo, H., Dispas, A., Orlandini, S., Hubert, P., Ziemons, E., & Hubert, C. (20 May 2019). Principles of Analytical Quality by Design for the development of quality control methods in a pharmaceutical context [Paper presentation]. 20th Forum of Pharmaceutical Sciences - BSPS, Brussels, Belgium. https://hdl.handle.net/2268/235005

The most cited

127 citations (Scopus®)

Deidda, R.* , Sacre, P.-Y.* , Clavaud, M., Coic, L., Avohou, T. H., Hubert, P., & Ziemons, E. (May 2019). Vibrational spectroscopy in analysis of pharmaceuticals: Critical review of innovative portable and handheld NIR and Raman spectrophotometers. TrAC: Trends in Analytical Chemistry, 114, 251-259. doi:10.1016/j.trac.2019.02.035 https://hdl.handle.net/2268/233370

Avohou, T. H. (2022). Bayesian one-class classification models: Application to pharmaceutical quality control using vibrational spectroscopy [Doctoral thesis, ULiège - University of Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/294487

Avohou, T. H., Sacre, P.-Y., Hamla, S., Lebrun, P., Hubert, P., & Ziemons, E. (05 September 2022). Optimizing the soft independent modeling of class analogy (SIMCA) using statistical prediction regions. Analytica Chimica Acta, 1229, 340339. doi:10.1016/j.aca.2022.340339
Peer Reviewed verified by ORBi

Emonds-Alt, G., Malherbe, C., Kasemiire, A., Avohou, T. H., Hubert, P., Ziemons, E., Monbaliu, J.-C., & Eppe, G. (03 June 2022). Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water. Talanta, 249, 123640. doi:10.1016/j.talanta.2022.123640
Peer Reviewed verified by ORBi

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (04 March 2022). Interpretable One-Class Classification of Raman Spectra Using Prediction Bands Estimated by Wavelet Regression. Analytical Chemistry, 94, 4183-4191. doi:10.1021/acs.analchem.1c04098
Peer Reviewed verified by ORBi

Sacre, P.-Y., Waffo Tchounga, C. A., Ciza Hamuli, P., Avohou, T. H., De Bleye, C., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (02 February 2022). Applications of vibrational spectroscopy and imaging for the analysis of substandard or falsified medicines [Paper presentation]. CIRM DAY.

Sacre, P.-Y., Waffo Tchounga, C. A., Ciza Hamuli, P., Avohou, T. H., De Bleye, C., Hubert, P., Marini Djang'Eing'A, R., & Ziemons, E. (2022). Applications of vibrational spectroscopy and hyperspectral imaging for the analysis of substandard and falsified medicines [Paper presentation]. 12th International Symposium on Drug Analysis and the 32nd International Symposium on Pharmaceutical and Biomedical Analysis, Mons, Belgium.
Peer reviewed

Emonts, P., Avohou, T. H., Hubert, P., Ziemons, E., Fillet, M., & Dispas, A. (October 2021). Optimization of a robust and reliable FITC labeling process for CE-LIF analysis of pharmaceutical compounds using design of experiments strategy. Journal of Pharmaceutical and Biomedical Analysis, 205, 114304. doi:10.1016/j.jpba.2021.114304
Peer Reviewed verified by ORBi

Emonts, P., Avohou, T. H., Hubert, P., Ziemons, E., Fillet, M., & Dispas, A. (October 2021). Development of a sensitive MEKC-LIF method for the analysis of synthetic cathinones and amphetamines Paul Emonts [Poster presentation]. SEP2021, Paris, France.

Deidda, R., Avohou, T. H., Dumont, E., Hubert, C., Hubert, P., De Bleye, C., & Ziemons, E. (2021). Application of the analytical quality by design principles to the development of a qualitative surface-enhanced Raman scattering method: A proof of concept. Journal of Raman Spectroscopy. doi:10.1002/jrs.6249
Peer Reviewed verified by ORBi

Kasemiire, A., Avohou, T. H., De Bleye, C., Sacre, P.-Y., Dumont, E., Hubert, P., & Ziemons, E. (11 June 2021). Design of experiments and design space approaches in the pharmaceutical bioprocess optimization. European Journal of Pharmaceutics and Biopharmaceutics, 166 (September), 144-154. doi:10.1016/j.ejpb.2021.06.004
Peer Reviewed verified by ORBi

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (03 February 2021). Using prediction bands for near-infrared spectra for authentication and verification of drug products [Paper presentation]. eChimiométrie 2021.

Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (01 February 2021). A probabilistic class-modelling method based on prediction bands for functional spectral data: Methodological approach and application to near-infrared spectroscopy. Analytica Chimica Acta, 1144, 130-149. doi:10.1016/j.aca.2020.11.039
Peer Reviewed verified by ORBi

NEEMA UFOYMUNGU, Y., JUAKALI SIHALIKYOLO, J. J., Marini Djang'Eing'A, R., KATENGA BOSUNGA, G., Avohou, T. H., LEDUC, S., BOEMER, F., & BATINA AGASA, S. (2020). Performance of Sickle SCAN® in the Screening of Sickle Cell Disease in Kisangani Pregnant Women and Attitude towards Results. Open Journal of Blood Diseases. doi:10.4236/ojbd.2020.102003
Peer reviewed

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (18 February 2020). A one-class Classification method based on depth statistics : applications to process analytical technology (PAT) and detection of counterfeited drugs [Paper presentation]. Weekly CIRM Scientific Seminar, Liege, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (28 January 2020). A probabilistic class-modelling method based on Bayesian prediction intervals for functional depth (vs outlyingness) statistics [Paper presentation]. Chimiométrie 2020, Liège, Belgium.

Emonds-Alt, G., Avohou, T. H., Kasemiire, A., Malherbe, C., Monbaliu, J.-C., Ziemons, E., & Eppe, G. (28 January 2020). In-line monitoring of glyphosate in a microfluidic setup by SERS, development and optimization by DoE [Poster presentation]. Chimiométrie XXI, Liège, Belgium.

Dispas, A., Emonts, P., Avohou, T. H., Ziemons, E., Hubert, P., & Fillet, M. (January 2020). Design of experiments approach to optimize FITC labeling process [Poster presentation]. Chimiométrie 2020, Liège, Belgium.

Avohou, T. H., Lebrun, P., Rozet, E., & Boulanger, B. (2020). Bayesian methods in design and analysis of stability studies. In E. Lesaffre, G. Baio, ... B. Boulanger, Bayesian methods in pharmaceutical research (pp. 391-405). Boca Raton, United States: CRC Press.
Peer reviewed

Penoy, N., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (11 December 2019). A quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics? [Paper presentation]. Second CIRM Scientific Day, Liège, Belgium.

Penoy, N., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (11 December 2019). A quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics? [Paper presentation]. Second CIRM Scientific Day, Liège, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (2019). Concept and prototype V4F for classification [Paper presentation]. Meeting for transfer of knowledge to Biion & Pharmalex, V4F, Mont Saint-Guilbert, Belgium.

Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (15 November 2019). Class-modelling methods based on 𝜷-expectation tolerance regions for functional spectral (NIR and Raman) data [Paper presentation]. Scientific Workshops, Pharmalex, Mont Sain-Guilbert, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (24 October 2019). Spectrophotomètres portables :l’analyse chimique à portée de tous? [Paper presentation]. Liège Créative, Liege, Belgium.

Avohou, T. H., Sacre, P.-Y., Hubert, P., & Ziemons, E. (2019). Logiciel Vibra4Fake 2020.

Ciza Hamuli, P.* , Sacre, P.-Y.* , Waffo Tchounga, C., Coic, L., Avohou, T. H., Mbinze, J., Ngono, R., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (01 September 2019). Comparing the qualitative performances of handheld NIR and Raman spectrophotometers for the detection of falsified pharmaceutical products. Talanta, 202, 469-478. doi:10.1016/j.talanta.2019.04.049
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Emonds-Alt, G., Avohou, T. H., Kasemiire, A., Malherbe, C., Monbaliu, J.-C., Ziemons, E., & Eppe, G. (17 June 2019). Integrated microfluidic device for in-line monitoring of glyphosate assisted by Surface Enhanced Raman Spectroscopy [Paper presentation]. 17th International Conference on Chemistry and the Environment, Thessaloniki, Greece.

Ciza Hamuli, P., Sacre, P.-Y., Waffo Tchounga, C. A., Coic, L., Avohou, T. H., mbinze, J., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (20 May 2019). Detection of falsified pharmaceutical products using Handheld NIR and Raman spectrophotometers [Paper presentation]. BSPS 2019 Forum of Pharmaceutical Sciences - May 20th 2019 - Brussels, Bruxelles, Belgium.

Penoy, N., Bigazzi, W., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (20 May 2019). LIPOSOME PRODUCTION BY INNOVATIVE METHOD USING SUPERCRITICAL FLUIDS [Paper presentation]. 20th Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Deidda, R., Avohou, T. H., Jambo, H., Dispas, A., Orlandini, S., Hubert, P., Ziemons, E., & Hubert, C. (20 May 2019). Principles of Analytical Quality by Design for the development of quality control methods in a pharmaceutical context [Paper presentation]. 20th Forum of Pharmaceutical Sciences - BSPS, Brussels, Belgium.

Deidda, R.* , Sacre, P.-Y.* , Clavaud, M., Coic, L., Avohou, T. H., Hubert, P., & Ziemons, E. (May 2019). Vibrational spectroscopy in analysis of pharmaceuticals: Critical review of innovative portable and handheld NIR and Raman spectrophotometers. TrAC: Trends in Analytical Chemistry, 114, 251-259. doi:10.1016/j.trac.2019.02.035
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Deidda, R., Avohou, T. H., Kasemiire, A., Dumont, E., De Bleye, C., Hubert, P., Hubert, C., & Ziemons, E. (30 January 2019). Optimisation of a surface enhanced Raman scattering method using design of experiments and Bayesian design space modelling [Poster presentation]. Chimiométrie XIX - 2019, Montpellier, France.

Deidda, R., Avohou, T. H., Baronti, R., Davolio, P. L., Pasquini, B., Del Bubba, M., Hubert, C., Hubert, P., Orlandini, S., & Furlanetto, S. (2019). Analytical quality by design: development and control strategy for a LC method to evaluate the cannabinoids content in cannabis olive oil extracts. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2019.01.032
Peer Reviewed verified by ORBi

Huat, J., Dossou-Yovo, E., Guindo, M., Avohou, T. H., Furlan, T., Sanogo, F., & Touré, A. (2019). A spatial database of lowland cropping systems in Benin, Mali and Sierra Leone. Data in Brief, 24. doi:10.1016/j.dib.2019.103876
Peer Reviewed verified by ORBi

Coic, L., Sacre, P.-Y., Avohou, T. H., Ciza, P., Marini Djang'Eing'A, R., Fillet, M., Hubert, P., & Ziemons, E. (01 January 2019). Authentication of falsified medicine tablets by handheld Raman spectroscopy class modeling [Paper presentation]. Chimiométrie 2019, Montpellier, France.

Deidda, R., Avohou, T. H., Orlandini, S., Baronti, R., Pasquini, B., Furlanetto, S., Hubert, P., & Hubert, C. (19 December 2018). Control strategy applied to a LC-DAD quality control method as part of the analytical quality by design approach: one year of routine use [Paper presentation]. 1st CIRM Scientific Day, Liège, Belgium.

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (19 December 2018). SFC-MS for the quality control of cannabis: addressing the potential adulteration with synthetic cannabinoids [Paper presentation]. CIRM Day (1st edition).

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (19 October 2018). SFC-MS as a preventive tool for the quality control of potentially adulterated cannabis with synthetic cannabinoids [Paper presentation]. SFC 2018, Strasbourg, France.

Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (12 September 2018). A novel probabilistic spectral matching strategy based on wavelets regression and Bayesian modeling for product identification and quality verification [Paper presentation]. 11th International Symposium on Drug Analysis and 29th International Symposium on Pharmaceutical and Biomedical Analysis, DA-PB, Leuven, Belgium.

Deidda, R., Avohou, T. H., Orlandini, S., Baronti, R., Pasquini, B., Furlanetto, S., Hubert, P., & Hubert, C. (September 2018). Analytical Quality by Design: development and control strategy for a RP-HPLC method implemented in routine to evaluate the cannabinoids content in cannabis olive oil extracts [Poster presentation]. International Symposium DA-BPA 2018, Leuven, Belgium.

Sacre, P.-Y., Coic, L., Avohou, T. H., Sakira, K., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Forensic formulation fingerprinting of falsified medicine by Raman hyperspectral imaging [Paper presentation]. Medicine Quality and Public Health 2018, Oxford, United Kingdom.

Coic, L., Sacre, P.-Y., Avohou, T. H., Sakira, K., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Solving composition of falsified artemether/lumefantrine formulation by hyperspectral imaging [Poster presentation]. DA-PBA 2018 11th International Symposium on Drug Analysis (DA 2018), 29th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2018).

Sacre, P.-Y., Avohou, T. H., Lebrun, P., Coic, L., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Bayesian securing of the pharmaceutical supply chain [Paper presentation]. Medicine Quality and Public Health 2018, Oxford, United Kingdom.

Dispas, A., Avohou, T. H., Lebrun, P., Hubert, P., & Hubert, C. (April 2018). ‘Quality by Design’ approach for the analysis of impurities in pharmaceutical drug products and drug substances. TrAC: Trends in Analytical Chemistry, 101, 24-33. doi:10.1016/j.trac.2017.10.028
Peer Reviewed verified by ORBi

Salvé, M., Avohou, T. H., Monbaliu, J.-C., Lebrun, P., Lemaire, C., Damblon, C., De Tullio, P., Hubert, P., Hustinx, R., & Luxen, A. (12 February 2018). NOTA‐PRGD2 and NODAGA‐PRGD2: Bioconjugation, characterization, radiolabelling, and design space. Journal of Labelled Compounds and Radiopharmaceuticals, 61, 487-500. doi:10.1002/jlcr.3613
Peer Reviewed verified by ORBi

Avohou, T. H., Cailletaud, J., Clavaud, M., Coic, L., De Bleye, C., Deidda, R., Dumont, E., Sacre, P.-Y., Hubert, P., & Ziemons, E. (15 January 2018). De l'intérêt de la spectroscopie Raman pour l'analyse pharmaceutique [Paper presentation]. Conférence Universitaire de Suisse Occidentale, Genève, Switzerland.

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (2018). Quality control of medicinal cannabis: implementation of a generic sfc-ms method to address counterfeiting with synthetic cannabinoids [Poster presentation]. International Symposium DA-PBA 2018, Leuven, Belgium.

Avohou, T. H., Hubert, C., Debrus, B., Lebrun, P., Rudaz, S., Boulanger, B., & Hubert, P. (2018). Statistical methods in Quality by Design approach to Liquid Chromatography method development. In S. Fekete & I. Molnar, Software-Assisted Method Development for Modeling High Performance Liquid Chromatography (pp. 109-150). London, United Kingdom: World Scientific Publishing. doi:10.1142/q0161
Peer reviewed

Coic, L., Sacre, P.-Y., Avohou, T. H., Deidda, R., De Bleye, C., Dumont, E., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (2018). Recent developments of Raman spectroscopy for the qualitative analysis of falsified and substandard medicines. European Pharmaceutical Review.

Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (2018). Implementation of a generic SFC-MS method for the quality control of potentially counterfeited medicinal cannabis with synthetic cannabinoids. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1092, 332-342. doi:10.1016/j.jchromb.2018.05.049
Peer Reviewed verified by ORBi

Avohou, T. H., Cailletaud, J., Clavaud, M., De Bleye, C., Dumont, E., Marini Djang'Eing'A, R., Sacre, P.-Y., Hubert, P., & Ziemons, E. (20 September 2017). Modern spectral analyses fro drug identification and quantification: From PAT to patient protection [Paper presentation]. Arlenda Day, Bruxelles, Belgium.

Avohou, T. H., Lambert, P., Govaerts, B., & Lebrun, P. (24 April 2017). Bayesian predictions of probabilities of out-of-specification drug products during a stability analysis [Poster presentation]. 6th International Biometric Society Channel Network Conference, Hasselt, Belgium.

Mitchodigni, I. M., Amoussa Hounkpatin, W., Ntandou-Bouzitou, G., Avohou, T. H., Termote, C., Kennedy, G., & Hounhouigan1, J. D. (2017). Complementary feeding practices: determinants of dietary diversity and meal frequency among children aged 6–23 months in Southern Benin. Food Security, 9, 1117–1130. doi:10.1007/s12571-017-0722-y
Peer Reviewed verified by ORBi

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