Reference : Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/208629
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
English
Sabatel, Catherine* mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Radermecker, Coraline* mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Fievez, Laurence* mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Paulissen, Geneviève mailto [Université de Liège > Département des sciences cliniques > Hépato-gastroentérologie >]
Chakarov, Svetoslav [Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore 138648, Singapore > > > >]
Fernandes, Claudia [Université de Liège - ULiège > Laboratory of Cellular and Molecular Immunology, GIGA Research > > >]
Olivier, Sabine [Université de Liège - ULiège > Laboratory of Cellular and Molecular Immunology, GIGA Research > > >]
Toussaint, Marie [Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London W2 1PG, UK > > > >]
Pirottin, Dimitri mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > Département des sciences fonctionnelles (DSF) >]
Xiao, Xue mailto [Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
Quatresooz, Pascale mailto [Université de Liège > Département des sciences biomédicales et précliniques > Histologie >]
Sirard, Jean-Claude [University of Lille,CHU Lille, Institut Pasteur de Lille, France > INSERM U1019, CNRSUMR8204, Center for Infection and Immunity of Lille > > >]
Cataldo, Didier mailto [Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Gillet, Laurent mailto [Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
Bouabe, Hicham [Babraham Institute, Cambridge CB22 3AT, UK > Laboratory of Lymphocyte Signalling and Development > > >]
Desmet, Christophe mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Ginhoux, Florent [Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore 138648, Singapore > > > >]
Marichal, Thomas* mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Bureau, Fabrice* mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
* These authors have contributed equally to this work.
2017
Immunity
46
3
457-473
Yes (verified by ORBi)
International
1074-7613
1097-4180
United States
[en] CCR2 ; CpG ; IL-10 ; TLR9 ; asthma ; hygiene hypothesis ; lung ; monocytes ; regulatory macrophages ; spleen
[en] Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10-/- CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment.
Giga-Infection, Immunity and Inflammation
Researchers ; Professionals
http://hdl.handle.net/2268/208629
10.1016/j.immuni.2017.02.016

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