Profil

Desmet Christophe

GIGA I3 - Cellular and Molecular Immunology

Département des sciences cliniques

Département des sciences fonctionnelles (DSF)

See author's contact details
ORCID
0000-0002-5723-2449
Main Referenced Co-authors
Bureau, Fabrice  (108)
Lekeux, Pierre  (69)
Marichal, Thomas  (49)
Fievez, Laurence  (35)
Mesnil, Claire  (24)
Main Referenced Keywords
Lung (11); Inflammation (6); Animals (5); lung (5); Macrophages (5);
Main Referenced Unit & Research Centers
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège [BE] (12)
FARAH - Fundamental and Applied Research for Animals and Health - ULiège [BE] (2)
GIGA‐R - Giga‐Research - ULiège [BE] (2)
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE] (2)
GIGA I3-Cellular and Molecular Immunology - ULiège [BE] (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (59)
Veterinary medicine & animal health (54)
Immunology & infectious disease (32)
Anatomy (cytology, histology, embryology...) & physiology (21)
Life sciences: Multidisciplinary, general & others (10)

Publications (total 140)

The most downloaded
313 downloads
Schurmans, S., Vande Catsyne, C.-A., Desmet, C., & Moes, B. (2021). The phosphoinositide 5-phosphatase INPP5K: from gene structure to in vivo functions. Advances in Biological Regulation. doi:10.1016/j.jbior.2020.100760 https://hdl.handle.net/2268/250960

The most cited

1548 citations (Scopus®)

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008). Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell, 133 (6), 1019-1031. doi:10.1016/j.cell.2008.03.039 https://hdl.handle.net/2268/139059

The most significant

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353
Peer Reviewed verified by ORBi

Van Hulst, G., Jorssen, J., Jacobs, N., Henket, M., Louis, R., Schleich, F., Bureau, F., & Desmet, C. (2022). Anti-IL-5 mepolizumab minimally influences residual blood eosinophils in severe asthma. European Respiratory Journal. doi:10.1183/13993003.00935-2021
Peer Reviewed verified by ORBi

Rosu, A., El Hachem, N., Rapino, F., Rouault-Pierre, K., Jorssen, J., SOMJA, J., Ramery, E., Thiry, M., Nguyen, L., Jacquemyn, M., Daelemans, D., Adams, C. M., Bonnet, D., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. Journal of Experimental Medicine, 218 (3). doi:10.1084/jem.20200662
Peer reviewed

Desmet, C., Gallenne, T., Prieur, A., Reyal, F., Visser, N., Wittner, B., Smit, M., Geiger, T., Laoukili, J., Iskit, S., Rodenko, B., Zwart, W., Evers, B., Horlings, H., Ajouaou, A., Zevenhoven, J., van Vliet, M., Ramaswamy, S., Wessels, L., & Peeper, D. S. (2013). Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1222085110
Peer Reviewed verified by ORBi

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K. J., Bureau, F.* , & Desmet, C.*. (August 2011). DNA released from dying host cells mediates aluminum adjuvant activity. Nature Medicine, 17, 996-1002. doi:10.1038/nm.2403
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.


Jorssen, J.* , Van Hulst, G.* , Mollers, K., Pujol, J., Petrellis, G., Baptista, A. P., Schetters, S., Baron, F., Caers, J., Lambrecht, B. N., Dewals, B. G., Bureau, F.* , & Desmet, C.*. (2024). Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification. Immunity. doi:10.1016/j.immuni.2024.04.027
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Burniat, A., Noël, A., Colige, A., Vanderplasschen, A., de Kerchove d'Exaerde, A., Kupper Cardozo, A., Van Keymeulen, A., Moens, A., Bondue, A., Herpain, A., Marchant, A., Loumaye, A., Beck, B., Van den Heyden, B., Corvilain, B., Lakaye, B., Rogister, B., Malgrange, B., Michiels, C., ... Brunko, E. (2023). Cent scientifiques répliquent à SEA (Suppression des Expériences sur l’Animal vivant) et dénoncent sa désinformation. La Libre Belgique.

Moes, B., Li, H., Molina Ortiz, P., Radermecker, C., Rosu, A., Vande Catsyne, C.-A., Sayyed, S. A., Fontela Joao, Duque, M., Mostafa, A., Azzi, A., Barata Joao T., Merino Ramon, Xu, C., Desmet, C., & Schurmans, S. (2023). INPP5K controls the dynamic structure and signaling of wild type and mutated, leukemia-associated IL7 receptors. Blood, 141, 1708-1717. doi:10.1182/blood.2022017819
Peer Reviewed verified by ORBi

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353
Peer Reviewed verified by ORBi

Wathieu, C., Tielens, S., Lavergne, A., Shostak, K., Rolot, M., El Hachem, N., Xu, X., Close, P., Nguyen, L., Desmet, C., Dewals, B. G., & CHARIOT, A. (10 May 2022). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Paper presentation]. Type 2 Immunity in Early Life Symposium, Liège, Belgium.

Van Hulst, G., Jorssen, J., Jacobs, N., Henket, M., Louis, R., Schleich, F., Bureau, F., & Desmet, C. (2022). Anti-IL-5 mepolizumab minimally influences residual blood eosinophils in severe asthma. European Respiratory Journal. doi:10.1183/13993003.00935-2021
Peer Reviewed verified by ORBi

Van Hulst, G., Jorssen, J., Jacobs, N., Henket, M., Louis, R., Schleich, F., Bureau, F., & Desmet, C. (2022). Reply: Ex vivo SOCS3 gene responsiveness to alarmins in eosinophils of mepolizumab-treated patients is as yet of unknown biological significance. European Respiratory Journal, 60 (1). doi:10.1183/13993003.00981-2022
Peer Reviewed verified by ORBi

Fastrès, A., Roels, E., Pirottin, D., Fievez, L., Tutunaru, A.-C., Bolen, G., Merveille, A.-C., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (2022). Osteopontin-expressing macrophages in dogs affected with canine idiopathic pulmonary fibrosis, a model for human idiopathic pulmonary fibrosis [Poster presentation]. 21st International Colloquium on Lung and Airway Fibrosis (ICLAF).

Rosu, A., El Hachem, N., Rapino, F., Rouault-Pierre, K., Jorssen, J., SOMJA, J., Ramery, E., Thiry, M., Nguyen, L., Jacquemyn, M., Daelemans, D., Adams, C. M., Bonnet, D., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. Journal of Experimental Medicine, 218 (3). doi:10.1084/jem.20200662
Peer reviewed

Schurmans, S., Vande Catsyne, C.-A., Desmet, C., & Moes, B. (2021). The phosphoinositide 5-phosphatase INPP5K: from gene structure to in vivo functions. Advances in Biological Regulation. doi:10.1016/j.jbior.2020.100760
Peer Reviewed verified by ORBi

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Kerselidou, D., Dohai, B. S., Nelson, D. R., Daakour, S., De Cock, N., Hassoun, Z. E. O., Kim, D.-K., Olivet, J., El Assal, D. C., Jaiswal, A., Alzahmi, A., Saha, D., Pain, C., Matthijssens, F., Lemaitre, P., Herfs, M., Chapuis, J., Ghesquiere, B., Vertommen, D., ... Twizere, J.-C. (2021). Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Science Advances, 7 (19). doi:10.1126/sciadv.abe8349
Peer Reviewed verified by ORBi

Lemaitre, P., Bai, Q., Legrand, C., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of the Transfer RNA Wobble Uridine-Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4. Journal of immunology (Baltimore, Md. : 1950). doi:10.4049/jimmunol.2000521
Peer reviewed

Van Hulst, G., Bureau, F., & Desmet, C. (2021). Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity? International Journal of Molecular Sciences, 22 (18). doi:10.3390/ijms221810150
Peer Reviewed verified by ORBi

Fastrès, A., Pirottin, D., Fievez, L., Tutunaru, A.-C., Bolen, G., Merveille, A.-C., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (15 December 2020). Identification of pro-fibrotic macrophage populations by single-cell transcriptomic analysis in West Highland white terriers affected with canine idiopathic pulmonary fibrosis. Frontiers in Immunology, 11, 611749. doi:10.3389/fimmu.2020.611749
Peer Reviewed verified by ORBi

Fastrès, A., Pirottin, D., Fievez, L., Tutunaru, A.-C., Bolen, G., Merveille, A.-C., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (20 November 2020). Identification of pro-fibrotic macrophages populations by single-cell transcriptomic analysis in West Highland white terriers affected with canine idiopathic pulmonary fibrosis [Paper presentation]. 7th FARAH DAY, Liège, Belgium.

Louis, R., Bureau, F., & Desmet, C. (September 2020). Advances toward precision medicine for asthma. Biochemical Pharmacology, 179. doi:10.1016/j.bcp.2020.114081
Peer Reviewed verified by ORBi

Fastrès, A., Pirottin, D., Fievez, L., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (30 July 2020). Characterization of the bronchoalveolar lavage fluid by single cell gene expression analysis in healthy dogs: a promising technique. Frontiers in Immunology, 11, 1707. doi:10.3389/fimmu.2020.01707
Peer Reviewed verified by ORBi

Van Hulst, G., Batugedara, H. M., Jorssen, J., Louis, R., Bureau, F., & Desmet, C. (2020). Eosinophil diversity in asthma. Biochemical Pharmacology, 179. doi:10.1016/j.bcp.2020.113963
Peer Reviewed verified by ORBi

Fastrès, A., Pirottin, D., Fievez, L., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (2020). Characterization of the bronchoalveolar lavage fluid by single cell gene expression analysis in healthy dogs: a promising technique. Journal of Veterinary Internal Medicine, 34 (6). doi:10.1111/jvim.15924

Arnone, M., Van Hulst, G., Desmet, C., Bureau, F., Jacobs, N., Gerday, S. (Other coll.), HENKET, M. (Other coll.), & LOUIS, R. (Other coll.). (21 May 2019). Building a comprehensive map of immune cell populations in sputum from patients with eosinophilic asthma [Poster presentation]. EDT-Immunology day.

El Abbas, S., Radermecker, C., Bai, Q., BEGUIN, C., Schyns, J., Meunier, M., Pirottin, D., Desmet, C., Meuwis, M.-A., Art, T., Louis, E., Tam, S.-Y., Tsai, M., Bureau, F., Galli, S. J., & Marichal, T. (2019). Epithelial RABGEF1 deficiency promotes intestinal inflammation by dysregulating intrinsic MYD88-dependent innate signaling. Mucosal Immunology. doi:10.1038/s41385-019-0211-z
Peer Reviewed verified by ORBi

Farhat, K., Bodart, G., Charlet-Renard, J. D. C., Desmet, C., Moutschen, M., Beguin, Y., Baron, F., Melin, P., Quatresooz, P., Parent, A.-S., Desmecht, D., Sirard, J.-C., Salvatori, R., Martens, H., & Geenen, V. (02 October 2018). Growth hormone (GH) deficient mice with GHRH ablation are severely deficient in vaccine and immune responses against Streptococcus pneumoniae. Frontiers in Immunology, 9, 2175. doi:10.3389/fimmu.2018.02175
Peer Reviewed verified by ORBi

Van hede, D., Polese, B., Humblet, C., Wilharm, A., Renoux, V., DORTU, E., de Leval, L., Delvenne, P., Desmet, C., Bureau, F., Vermijlen, D., & Jacobs, N. (June 2018). Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation [Poster presentation]. Gamma delta conferance, Bordeaux, France.

Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express.

Farhat, K., Bodart, G., Desmet, C., Moutschen, M., Beguin, Y., Baron, F., Salvatori, R., Martens, H., & Geenen, V. (20 March 2018). GHRH-deleted Mice Are Severely Deficient in Vaccine And Immunological Responses Against Streptococcus Pneumoniae [Paper presentation]. ENDO 2018, Chicago, United States.

Liégeois, M.* , Legrand, C.* , Desmet, C.* , Marichal, T.* , & Bureau, F.*. (2018). The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity. Cellular Immunology, 330, 91-96. doi:10.1016/j.cellimm.2018.02.001
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Farhat, K., Bodart, G., RENARD, J. D. C., Desmet, C., MOUTSCHEN, M., Beguin, Y., Baron, F., Salvatori, R., Geenen, V., & Martens, H. (23 May 2017). A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH) [Poster presentation]. European Congress of Endocrinology, Lisbonne, Portugal. doi:10.1530/endoabs.49.EP883

Farhat, K., Bodart, G., Renard, C., Desmet, C., MOUTSCHEN, M., BARON, F., Beguin, Y., Salvatori, R., Martens, H., & GEENEN, V. (May 2017). A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH) [Poster presentation]. The 19th European Congress of Endocrinology, Lisbon, Portugal.

Bureau, F., Marichal, T., Desmet, C., Sabatel, C., Radermecker, C., Fievez, L., & olivier, S. (09 March 2017). Procédés de différenciation in vitro de monocytes en macrophages régulateurs.

Rosu, A., Bai, Q., Ramery, E., Thiry, M., Close, P., Bureau, F., & Desmet, C. (03 February 2017). Loss of transfer RNA U34 modifying enzymes impairs hematopoietic stem and progenitor cell differentiation and function [Poster presentation]. Keystone Symposia: Hematopoiesis, Banff, Canada.

Sabatel, C., Radermecker, C., Fievez, L., PAULISSEN, G., Chakarov, S., Fernandes, C., Olivier, S., Toussaint, M., Pirottin, D., Xiao, X., QUATRESOOZ, P., Sirard, J.-C., CATALDO, D., Gillet, L., Bouabe, H., Desmet, C., Ginhoux, F., Marichal, T., & Bureau, F. (01 February 2017). Bacterial CpG-DNA prevents asthma by expanding lung interstitial regulatory macrophages from local and splenic reservoir monocytes [Paper presentation]. GIGA DAY 2017, Liège, Belgium.

Sabatel, C.* , Radermecker, C.* , Fievez, L.* , Paulissen, G., Chakarov, S., Fernandes, C., Olivier, S., Toussaint, M., Pirottin, D., Xiao, X., Quatresooz, P., Sirard, J.-C., Cataldo, D., Gillet, L., Bouabe, H., Desmet, C., Ginhoux, F., Marichal, T.* , & Bureau, F.*. (2017). Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Immunity, 46 (3), 457-473. doi:10.1016/j.immuni.2017.02.016
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Van hede, D., Polese, B., Humblet, C., Wilharm, A., Renoux, V., Dortu, E., de Leval, L., Delvenne, P., Desmet, C., Bureau, F., Vermijlen, D., & Jacobs, N. (2017). Human papillomavirus oncoproteins induce a reorganization of epithelial-associated gammadelta T cells promoting tumor formation. Proceedings of the National Academy of Sciences of the United States of America, 114 (43), 9056-E9065. doi:10.1073/pnas.1712883114
Peer Reviewed verified by ORBi

Gallenne, T.* , Ross, K. N.* , Visser, N. L.* , Salony, * , Desmet, C., Wittner, B. S., Wessels, L. F. A., Ramaswamy, S., & Peeper, D. S. (2017). Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer. Oncotarget, 8 (13), 20572-20587. doi:10.18632/oncotarget.16244
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Farhat, K., Bodart, G., Desmet, C., Moutschen, M., Salvatori, R., Geenen, V., & Martens, H. (07 November 2016). Severe deficiency of the somatotrope GHRH/GH/IGF-1 axis induces a dramatic susceptibility to Streptococcus pneumoniae infection [Poster presentation]. Growth Hormone Research Society (GRS) and IGF Society, Tel Aviv, Israel.

Farhat, K., Bodart, G., RENARD, J. D. C., Desmet, C., Moutschen, M., Baron, F., Beguin, Y., Salvatori, R., Geenen, V., & Martens, H. (November 2016). Severe deficiency of the somatotrope GHRH/GH/IGF1 axis induces a dramatic susceptibility to Streptococcus pneumoniae infection [Paper presentation]. 50e Congrès de la Société Française d'Immunologie (SFI), Paris, France.

Mesnil, C., Raulier, S., Paulissen, G., Xiao, X., Birrell, M., Pirottin, D., Janss, T., Starkl, P., Ramery, E., HENKET, M., SCHLEICH, F., Radermecker, M., Thielemans, K., Gillet, L., Thiry, M., Belvisi, M., LOUIS, R., Desmet, C., Marichal, T., & Bureau, F. (21 October 2016). Lung resident eosinophils represent a distinct cell subset with homeostatic functions [Paper presentation]. FARAH Day 2016, Liege, Belgium.

Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Desmet, C., Nguyen, L., Leiden, S. A., Willis, A. E., Buettner, R., Chariot, A., & Close, P. (October 2016). ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer. Journal of Experimental Medicine, 213, 2503-2523. doi:10.1084/jem.20160397
Peer Reviewed verified by ORBi

Sabatel, C., Radermecker, C., Fievez, L., Paulissen, G., Chakarov, S., Toussaint, M., Desmet, C., Ginhoux, F., Marichal, T., & Bureau, F. (2016). CpG-DNA expand immunosuppressive interstitial macrophages from Ly6c+ local precursors. In Proceeding of Cell Symposia: 100 years of phagocytes.
Peer reviewed

Janss, T., Mesnil, C., Pirottin, D., Lemaitre, P., Marichal, T., Bureau, F.* , & Desmet, C.*. (2016). Interferon response factor-3 promotes the pro-Th2 activity of mouse myeloid CD11b+ dendritic cells. European Journal of Immunology, 46, 2614-2628.
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Mesnil, C.* , Raulier, S.* , Paulissen, G., Xiao, X., Birrell, M., Pirottin, D., Janss, T., Starkl, P., Ramery, E., HENKET, M., SCHLEICH, F., Radermecker, C., Thielemans, K., Gillet, L., Thiry, M., Belvisi, M., Louis, R., Desmet, C., Marichal, T.* , & Bureau, F.*. (2016). Lung-resident eosinophils represent a distinct regulatory eosinophil subset. Journal of Clinical Investigation, 126 (9), 3275-3295. doi:10.1172/JCI85664
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Janss, T., Mesnil, C., Pirottin, D., Lemaitre, P., Marichal, T., Bureau, F.* , & Desmet, C.*. (2016). Interferon response factor-3 promotes the pro-Th2 activity of mouse lung CD11b+ conventional dendritic cells in response to house dust mite allergens. European Journal of Immunology, 46 (11), 2614-2628. doi:10.1002/eji.201646513
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Raulier, S., Mesnil, C., Paulissen, G., Pirottin, D., Janss, T., Desmet, C., Marichal, T., & Bureau, F. (28 September 2015). Identification of a novel lung-resident eosinophil population with immunomodulatory properties in mice [Paper presentation]. ERS 2015 international congress, Amsterdam, Netherlands.

Sabatel, C., Radermecker, C., Fievez, L., Paulissen, G., Toussaint, M., Desmet, C., Marichal, T., Bureau, F., & Chakarov, S. (Other coll.). (08 September 2015). A lung-resident Ly6c+ monocyte proliferates to give rise to immunosuppressive lung macrophages [Poster presentation]. 4ème European Congress of Immunology, Vienne, Austria.

Frellstedt, L., Gosset, P., Kervoaze, G., Hans, A., Desmet, C., Pirottin, D., Bureau, F., Lekeux, P., & Art, T. (2015). The Innate Immune Response of Equine Bronchial Epithelial Cells is Altered by Training. Veterinary Research, 46 (3), 1-12. doi:10.1186/s13567-014-0126-3
Peer Reviewed verified by ORBi

Sabatel, C., Radermecker, C., Fievez, L., Paulissen, G., Chakarov, S., Desmet, C., Ginhoux, F., Toussaint, M., Marichal, T., & Bureau, F. (2015). A lung-resident Ly6c+ monocyte proliferates to give rise to immunosuppressive lung macrophages [Poster presentation]. ERS International congress.

Sabatel, C., Radermecker, C., Chakarov, S., Fievez, L., PAULISSEN, G., Toussaint, M., Desmet, C., Ginhoux, F., Marichal, T., & Bureau, F. (2015). A lung-resident Ly6c+ monocyte proliferates to give rise to immunosuppressive lung macrophages. European Respiratory Journal. Supplement, 46 (59), 5098.
Peer Reviewed verified by ORBi

Pirottin, D., Schurmans, S., Francois, C., Farnir, F., Closset, R., Bureau, F., & Desmet, C. (2014). Generation and validation of a mouse model for conditional inactivation of PLAGL1. In Proceedings of the 4th edition : FARAH Day 2014.

Mesnil, C., Sabatel, C., Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F., & Desmet, C. (2014). Resident CD11b+CD64-Ly6C-, but not neo-recruited inflammatory CD11b+CD64+Ly6C+ dendritic cells are able to induce allergic airway sensitization to house dust mite antigens. In proceeding of the 13th International Symposium on Dendritic Cells.
Peer reviewed

Frellstedt, L., Waldschmidt, I., Gosset, P., Desmet, C., Pirottin, D., Bureau, F., Farnir, F., Franck, T., Dupuis-Tricaud, M.-C., Lekeux, P., & Art, T. (2014). Training Modifies Innate Immune Responses in Blood Monocytes and in Pulmonary Alveolar Macrophages. American Journal of Respiratory Cell and Molecular Biology, 51 (1), 135-142. doi:10.1165/rcmb.2013-0341OC
Peer Reviewed verified by ORBi

Desmet, C. (2013). Adjuvants targeting the DNA sensing pathways – Alum based adjuvants. In K. Ishii & C. K. Tang (Eds.), Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology (pp. 271-312). Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-12-404732-7.00012-5

Desmet, C., Gallenne, T., Prieur, A., Reyal, F., Visser, N., Wittner, B., Smit, M., Geiger, T., Laoukili, J., Iskit, S., Rodenko, B., Zwart, W., Evers, B., Horlings, H., Ajouaou, A., Zevenhoven, J., van Vliet, M., Ramaswamy, S., Wessels, L., & Peeper, D. S. (2013). Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1222085110
Peer Reviewed verified by ORBi

Toussaint, M., Fievez, L., Drion, P., Cataldo, D., Bureau, F., Lekeux, P., & Desmet, C. (2013). Myeloid hypoxia-inducible factor 1alpha prevents airway allergy in mice through macrophage-mediated immunoregulation. Mucosal Immunology, 6 (3), 485-97. doi:10.1038/mi.2012.88
Peer Reviewed verified by ORBi

Mesnil, C., Sabatel, C., Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F., & Desmet, C. (2013). Resident CD11b+Ly6C-, not neo-recruited inflammatory CD11b+Ly6C+ dendritic cells mediate allergic airway sensitization to house dust mite antigens. In Proceeding of the Abcam symposium on Allergy and Asthma 2013.
Peer reviewed

Crotta, S., Davidson, S., Mahlakoiv, T., Desmet, C., Buckwalter, M., Albert, M., Staeheli, P., & Wack, A. (2013). Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathogens. doi:10.1371/journal.ppat.1003773
Peer Reviewed verified by ORBi

Mesnil, C., Sabatel, C., Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F., & Desmet, C. (2013). Resident lung CD11b+Ly6C- dendritic cells are responsible for allergic airway sensitization to house dust mite in mice. In Proceeding of International Congress of Immunology 2013.
Peer reviewed

Toussaint, M., Fievez, L., Drion, P., Cataldo, D., Bureau, F., Lekeux, P., & Desmet, C. (2013). Myeloid Hif1alpha counteracts allergic airway sensitization in mice through macrophage-mediated immunoregulation. In Abstract book of Keystone Symposium "Myeloid Cells: Regulation and Inflammation".
Peer reviewed

Frellstedt, L., Gosset, P., Desmet, C., Pirottin, D., Bureau, F., Waldschmidt, I., Dupuis-Tricaud, M.-C., Lekeux, P., & Art, T. (2013). Training modifies the innate immune response both in the airways and in blood in horses. In Proceedings of the ICI. doi:10.3389/conf.fimmu.2013.02.00083
Peer reviewed

Menten, C., Faccinetto, C., Golovchenko, M., Dupiereux-Fettweis, I., Van Lerberghe, P.-B., DUBOIS, S., Desmet, C., Elmoualij, B., Baron, F., Rudenko, N., Oury, C., Heinen, E., & Couvreur, B. (December 2012). Neutrophil Extracellular Traps (NET) Entrap and Kill Borrelia burgdorferi sensu stricto Spirochetes and Are not Affected by Ixodes ricinus Tick Saliva. Journal of Immunology, 189 (11), 5393-5401. doi:10.4049/jimmunol.1103771
Peer Reviewed verified by ORBi

El Abbas, S., Frellstedt, L., Art, T., Pirottin, D., Tosi, I., Dupuis, M.-C., Lekeux, P., Bureau, F., & Desmet, C. (19 October 2012). Characterization of T-helper lymphocytes in peripheral blood and bronchoalveolar lavage of healthy horses and in horses with recurrent airway obstruction [Poster presentation]. Proceedings of the 2nd Scientific Meeting of the Faculty of Veterinary Medicine, Liège, Belgium.

Frellstedt, L., Gosset, P., Desmet, C., Pirottin, D., Bureau, F., Lekeux, P., & Art, T. (19 October 2012). Investigation of the effect of exercise on the innate immunity in horses [Poster presentation]. Proceedings of the 2nd Scientific Meeting of the Faculty of Veterinary Medicine, Liège, Belgium.

Peeper, D. S., Desmet, C., & Reyal, F. (06 September 2012). Fra-1 target genes as drug targets for treating cancer.

Toussaint, M., Fievez, L., Drion, P., Cataldo, D., Bureau, F., Lekeux, P., & Desmet, C. (2012). Myeloid Hypoxia‐inducible factor 1α prevents airway allergy in mice through macrophage‐mediated immunoregulation. In Proceedings Giga Day 2012.
Peer reviewed

Mesnil, C., Sabatel, C., Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F., & Desmet, C. (2012). Resident non inflammatory CD11b+ lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice. In Proceedings Giga Day 2012.

Desmet, C., & Ishii, K. J. (2012). Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nature Reviews. Immunology, 12 (7), 479-491. doi:10.1038/nri3247
Peer Reviewed verified by ORBi

Mesnil, C.* , Sabatel, C.* , Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F.* , & Desmet, C.*. (2012). Resident CD11b(+)Ly6C(-) Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice. PLoS ONE, 7 (12), 53242. doi:10.1371/journal.pone.0053242
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Marichal, T., Bureau, F., & Desmet, C. (2012). L'ADN du soi, allie du systeme immunitaire pour la fonction adjuvante de l'alun. MS. Medecine Sciences, 28 (1), 31-3. doi:10.1051/medsci/2012281011

Mesnil, C., Sabatel, C., Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F., & Desmet, C. (2012). Resident non inflammatory CD11b+ lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice. In Proceeding of the J2R.
Peer reviewed

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobyiama, K., Lekeux, P., Cevaiyr, C., Akira, S., Ishii, K. J., Bureau, F., & Desmet, C. (2012). Release and Innate detection of host cell DNA mediates the adjuvant effects of aluminum salts on adaptive responses. In Proceedings of the 1St Winter School Immunology.
Peer reviewed

Toussaint, M., Fievez, L., Desmet, C., Pirottin, D., Farnir, F., Bureau, F., & Lekeux, P. (2012). Increased hypoxia-inducible factor 1alpha expression in lung cells of horses with recurrent airway obstruction. BMC Veterinary Research, 8 (1), 64. doi:10.1186/1746-6148-8-64
Peer Reviewed verified by ORBi

Wallemacq, H., Bedoret, D., Pujol, J., Desmet, C., Drion, P., Farnir, F., Mainil, J., Lekeux, P., Bureau, F., & Fievez, L. (2012). CD40 triggering induces strong cytotoxic T lymphocyte responses to heat-killed Staphylococcus aureus immunization in mice: a new vaccine strategy for staphylococcal mastitis. Vaccine, 30 (12), 2116-2124. doi:10.1016/j.vaccine.2012.01.039
Peer Reviewed verified by ORBi

Toussaint, M., Fievez, L., Lekeux, P., Bureau, F., & Desmet, C. (2011). Myeloid HIF-1alpha prevents airway allergy in mice by promoting macrophage-mediated immunosuppression. In Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (pp. 3). Liège, Belgium: Presses de la Faculté de Médecine Vétérinaire de l'Université de Liège.
Peer reviewed

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K. J., Bureau, F.* , & Desmet, C.*. (August 2011). DNA released from dying host cells mediates aluminum adjuvant activity. Nature Medicine, 17, 996-1002. doi:10.1038/nm.2403
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Marichal, T., Bedoret Denis, Mesnil Claire, Pichavant Murielle, Goriely Stanislas, Goldman Michel, Lekeux, P., Bureau, F., & Desmet, C. (2011). Interferon Response Factor-3 is essential for house dust mite-induced airway allergy. In Proceedings of the Belgian Thoracic Society Annual Meeting.
Peer reviewed

Marichal, T., Bedoret, D., Mesnil, C., Pichavant, M., Goriely, S., Trottein, F., Cataldo, D., Goldman, M., Lekeux, P., Bureau, F., & Desmet, C. (May 2011). Interferon Response Factor 3 is essential for house dust mite-induced airway allergy [Paper presentation]. Gaxo Smith Kline Award in Pneumology, Brussels, Belgium.

Marichal, T., Bedoret, D., Mesnil, C., Goriely, S., Goldman, M., Lekeux, P., Bureau, F., & Desmet, C. (2011). IRF3 is essential for house dust mite-induced airway allergy in mice. In Proceedings GIGA-Day 2011.

Paulissen, G., Rocks, N., Guéders, M., Bedoret, D., Crahay, C., Quesada Calvo, F., Hacha, J., Bekaert, S., Desmet, C., Foidart, J.-M., Bureau, F., Noël, A., & Cataldo, D. (2011). ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation. European Journal of Immunology, 41 (2), 380-91. doi:10.1002/eji.200940286
Peer Reviewed verified by ORBi

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K., Bureau, F., & Desmet, C. (2011). Self-DNA release mediates the adjuvant effects of aluminium salts [Poster presentation]. Cold Spring Harbor Laboratory, New-York, United States.

Marichal, T., Ohata, K., Mesnil, C., Kobyiama, K., Lekeux, P., Cevaiyr, C., Akira, S., Ishii, K. J., Bureau, F., & Desmet, C. (2011). Release and innate detection of host cell DNA mediates the adjuvant effects of aluminum salts. In Proceedings of te 4th International Conference on Crossroads between Innate and Adaptive Immunity.
Peer reviewed

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K., Bureau, F., & Desmet, C. (2011). IRF3-dependent activation of inflammatory dendritic cells by extracellular host DNA mediates the adjuvant activity of alum on TH2 responses [Poster presentation]. 25th Annual Meeting of the European Macrophage and Dendritic cell Society, Brussels, Belgium.

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K., Bureau, F., & Desmet, C. (2011). Release and innate immune detection of host cell DNA mediate the adjuvant activity of aluminum salts [Poster presentation]. 4th International Conference on Crossroads between Innate and Adaptive Immunity, Mykonos, Greece.

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobyiama, K., Lekeux, P., Cevayir, C., Akira, S., Ishii, K. J., Bureau, F., & Desmet, C. (2011). IRF-3 dependent activation of inflammatory dendritic cells by extracellular host DNA mediates the adjuvant activity of alum on Th2 responses. In Proceedings of the 25th annual meeting of the European Macrophage and Dendritic Cell Society.
Peer reviewed

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobyiama, K., Lekeux, P., Cevayir, C., Akira, S., Ishii, K. J., Bureau, F., & Desmet, C. (2011). Self-DNA release mediates the adjuvant effect of aluminum salts. In Proceedings of the 4th meeting on Harnessing immunity to prevent and treat diseases.
Peer reviewed

Marichal, T., Ohata, K., Bedored, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K., Bureau, F., & Desmet, C. (2011). IRF3-dependent activation of inflammatory dendritic cells by extracellular host DNA mediates the adjuvant activity of alum on TH2 responses [Paper presentation]. 25th Annual Meeting of the European Macrophage and Dendritic cell Society, Brussels, Belgium.

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K., Bureau, F., & Desmet, C. (2011). Release and innate immune detection of host cell DNA mediate the adjuvant activity of aluminum salts [Paper presentation]. 4th International Conference on Crossroads between Innate and Adaptive Immunity, Mykonos, Greece.

Raulier, S., Bureau, F., Desmet, C., & Pirottin, D. (2011). Etude du rôle des facteurs de transcription c-Maf et MafB dans la différenciation et la fonction des macrophages régulateurs: impact sur l'homéostasie immune mucosale. In Proceedings of the 1st FMV Scientific Meeting.

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K., Bureau, F., & Desmet, C. (2011). Self-DNA release mediates the adjuvant effects of aluminum salts [Poster presentation]. Cold Spring Harbor Laboratory Meeting: 4th meeting on Harnessing immunity to prevent and treat disease, New York, United States.

Frellstedt, L., Gosset, P., Desmet, C., Pirottin, D., Bureau, F., Lekeux, P., & Art, T. (2011). Investigation of the innate immunity in the lower respiratory tract in exercising horses. In Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (pp. 2). Liège, Belgium: Presses de la Faculté de Médecine Vétérinaire de l'Université de Liège.

Legutko, A.* , Marichal, T.* , Fievez, L., Bedoret, D., Mayer, A., de Vries, H., Klotz, L., Drion, P., Heirman, C., CATALDO, D., LOUIS, R., Thielemans, K., Andris, F., Leo, O., Lekeux, P., Desmet, C.* , & Bureau, F.*. (2011). Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-γ Activity in Dendritic Cells. Journal of Immunology, 187 (9), 4517-4529. doi:10.4049/jimmunol.1101493
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Marichal, T., Bedoret Denis, Mesnil, C., Goriely Stanislas, Goldman Michel, Lekeux, P., Bureau, F., & Desmet, C. (2010). Interferon Response Factor 3 is required for airway allergy to house dust mite in mice. In Short Book of the Annual Congress of the Euopean Respiratory Society (ERS), Barcelone.
Peer reviewed

Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Kobyiama, K., Lekeux, P., Cevaiyr, C., Akira, S., Ishii, K. J., Bureau, F., & Desmet, C. (February 2010). Release and innate detection of hot cell DNA mediates the adjuvant effects of aluminium salts on adaptive responses [Paper presentation]. First winter school on Advanced Immunology, Awaji Yumebutai International conference center, Japan.

Bedoret, D., Bureau, F., & Desmet, C. (2010). Les macrophages interstitiels, gardiens de l'homeostasie immune pulmonaire. MS. Medecine Sciences, 26 (3), 229-31. doi:10.1051/medsci/2010263229

Marichal, T., Bedoret, D., Mesnil, C., Pichavant, M., Goriely, S., Trottein, F., Cataldo, D., Goldman, M., Lekeux, P., Bureau, F.* , & Desmet, C.*. (2010). Interferon Response Factor 3 is essential for house dust mite-induced airway allergy. Journal of Allergy and Clinical Immunology, 126 (4), 836-844. doi:10.1016/j.jaci.2010.06.009
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Warzée, B., Mesnil, C., Hober, D., Caloone, D., Pirottin, D., Garigliany, M.-M., Desmecht, D., Drion, P., Journot, L., Lekeux, P., Bureau, F.* , & Desmet, C.*. (2010). Viral induction of Zac1b through TLR3- and IRF3-dependent pathways. Molecular Immunology, 48 (1-3), 119-127. doi:10.1016/j.molimm.2010.09.004
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Marichal, T., Bedoret, D., Goriely, S., Goldman, M., Lekeux, P., Bureau, F., & Desmet, C. (2009). IRF3 is required for induction of allergic airway inflammation by dendritic cells [Poster presentation]. Abcam Allergy and Asthma Symposium, Bruges, Belgium.

Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B. G., Thielen, C., Gustin, P., de Leval, L., Van Rooijen, N., Le Moine, A., Vanderplasschen, A., Cataldo, D., Drion, P., Moser, M., Lekeux, P., & Bureau, F. (2009). Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. Journal of Clinical Investigation, 119 (12), 3723-38. doi:10.1172/JCI39717
Peer Reviewed verified by ORBi

Marichal, T., Bedoret, D., Goriely, M., Goldman, M., Lekeux, P., Bureau, F., & Desmet, C. (2009). IRF3 is required for the induction of allergic airway inflammation by lung dendritic cells in a mouse model of house dust mite-induced atopic asthma. In Abstracts of the 17th Annual European Respiratory Society Congress, Vienna, Austria.
Peer reviewed

Marichal, T., Bedoret, D., Goriely, M., Goldman, M., Lekeux, P., Bureau, F., & Desmet, C. (2009). IRF3 is required for induction of allergic airway inflammation by dendritic cells [Paper presentation]. Abcam Allergy and Asthma Symposium, Bruges, Belgium.

Peeper, D. S., Desmet, C., & Reyal, F. (17 March 2008). Markers providing prognosis of metastasis among cancer patients.

Desmet, C., Prieur, A., Reyal, F., Geiger, T., Smit, M., Horlings, H., Ajouaou, A., Meuleman, W., Van Vliet, M., Zevenhoven, J., Wessels, L., & Peeper, D. S. (2008). Fra-1 and its associated transcriptome are central determinants of human breast cancer metastasis [Poster presentation]. AACR Conference on Metastasis, Vancouver, Canada.

Henry, E., Desmet, C., Garze, V., Fievez, L., Bedoret, D., Heirman, C., Faisca, P., Jaspar, F., Gosset, P., Jacquet, A., Desmecht, D., Thielemans, K., Lekeux, P., Moser, M., & Bureau, F. (2008). Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma. Journal of Immunology, 181 (10), 7230-7242. doi:10.4049/jimmunol.181.10.7230
Peer Reviewed verified by ORBi

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008). Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell, 133 (6), 1019-1031. doi:10.1016/j.cell.2008.03.039
Peer Reviewed verified by ORBi

Henry, E., Desmet, C., Garzé, V., Fievez, L., Bedoret, D., Heirman, C., Faisca, P., Jaspar, F. J., Gosset, P., Jacquet, A. P. A., Desmecht, D., Lekeux, P., Moser, M., & Bureau, F. (2007). Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma [Poster presentation]. 11ème BIOFORUM de Liège, Liège, Belgium.

Fievez, L., Desmet, C., Henry, E., Pajak, B., Hegenbarth, S., Garzé, V., Bex, F., Jaspar, F., Boutet, P., Gillet, L., Vanderplasschen, A., Knolle, P. A., Leo, O., Moser, M., Lekeux, P., & Bureau, F. (2007). STAT5 is an Ambivalent Regulator of Neutrophil Homeostasis [Poster presentation]. 11ème BIOFORUM de Liège, Liège, Belgium.

Fievez, L., Desmet, C., Henry, E., Pajak, B., Hegenbarth, S., Garze, V., Bex, F., Jaspar, F., Boutet, P., Gillet, L., Vanderplasschen, A., Knolle, P. A., Leo, O., Moser, M., Lekeux, P., & Bureau, F. (2007). Stat5 Is an Ambivalent Regulator of Neutrophil Homeostasis. PLoS ONE, 2 (1), 727. doi:10.1371/journal.pone.0000727
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Seumois, G., Fillet, M., Gillet, L., Faccinetto, C., Desmet, C., Francois, C., Dewals, B. G., Oury, C., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2007). De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. Journal of Leukocyte Biology, 81 (6), 1477-1486. doi:10.1189/jlb.0806529
Peer Reviewed verified by ORBi

Desmet, C. (2006). Nuclear Factor-kappa B and Activator Protein-1: roles and potential as therapeutic targets in asthmatic inflammation. Annales de Médecine Vétérinaire, 150 S, 19-22.
Peer Reviewed verified by ORBi

Desmet, C., & Peeper, D. S. (2006). The neurotrophic receptor TrkB: a drug target in anti-cancer therapy ? Cellular and Molecular Life Sciences, 63 (7-8), 755-759. doi:10.1007/s00018-005-5490-8
Peer Reviewed verified by ORBi

Desmet, C. (2005). Le Facteur Nucléaire-kappaB et la Protéine Activatrice-1 : Roles et potentiel en tant que cibles thérapeutiques dans l'inflammation asthmatique [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/172713

Desmet, C., Gosset, P., Pajak, B., Garzé, V., Lekeux, P., & Bureau, F. (2005). Selective decoy-mediated inhibition of activator protein-1 activity in the airways pevents experimental asthmatic inflammation. European Respiratory Journal, 26, 233.
Peer Reviewed verified by ORBi

Desmet, C., Warzée, B., Gosset, P., Melotte, D., Rongvaux, A., Gillet, L., Fievez, L., Seumois, G., Vanderplasschen, A., Staels, B., Lekeux, P., & Bureau, F. (2005). Pro-inflammatory properties for thiazolidinediones. Biochemical Pharmacology, 69 (2), 255-265. doi:10.1016/j.bcp.2004.09.017
Peer Reviewed verified by ORBi

Fievez, L., Kirschvink, N., Onclinx, C., Belleflamme, M., Desmet, C., Peck, M., & Gustin, P. (2005). Protection by theophylline of inflammation and emphysema induced by repeated inhalation of cadmium chloride in rats. American Journal of Respiratory and Critical Care Medicine, 171, 93.
Peer Reviewed verified by ORBi

Kirschvink, N., Fievez, L., Desmet, C., Peck, M., Smith, N., Marlin, D., & Gustin, P. (2005). Theophylline increases glutathione in BAL of cadmium-exposed rats. In Proceedings of the American Thoracic Society, San Diego, California (pp. 750).
Peer reviewed

Fievez, L., Desmet, C., Seumois, G., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2005). STAT5 promotes granulocyte survival during inflammation. American Journal of Respiratory and Critical Care Medicine, 171, 325.
Peer Reviewed verified by ORBi

Desmet, C., Louis, R., Lekeux, P., & Bureau, F. (2005). Le controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme. Revue Médicale de Liège, 60 (10), 789-795.
Peer reviewed

Kirschvink, N., Leemans, J., Delvaux, F., Clercx, C., Fievez, L., Desmet, C., & Gustin, P. (2005). Repeatability of allergen challenges in a feline model of asthma : effect on airway reactivity and airway inflammation. In Proceedings of the American Thoracic Society, San Diego, California (pp. 780).
Peer reviewed

Desmet, C., Gosset, P., Garzé, V., Pajak, B., Fievez, L., Lekeux, P., & Bureau, F. (2005). Selective inhibition of AP-1 activity in airway immune cells ameliorates experimental asthma. In Proceedings: The American Thoracic Society (pp. 737).
Peer reviewed

Desmet, C., Gosset, P., Henry, E., Garze, V., Faisca, P., Vos, N., Jaspar, F., Burin Kefer, D., Lambrecht, B., Desmecht, D., Pajak, B., Moser, M., Lekeux, P., & Bureau, F. (2005). Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1. American Journal of Respiratory and Critical Care Medicine, 172 (6), 671-678. doi:10.1164/rccm.200410-1431OC
Peer Reviewed verified by ORBi

Desmet, C., Gosset, P., Pajak, B., Cataldo, D., Bentires-Alj, M., Lekeux, P., & Bureau, F. (2004). Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma. Journal of Immunology, 173 (9), 5766-5775. doi:10.4049/jimmunol.173.9.5766
Peer Reviewed verified by ORBi

Desmet, C., Gosset, P., Pajak, B., Cataldo, D., Bentires-Alj, M., Lekeux, P., & Bureau, F. (2004). Selective blockade of NF-kB activity in airway immune cells inhibits the effector phase of experimental asthma [Paper presentation]. 22nd Symposium of the Veterinary and Comparative Respiratory Society, Montreal, Canada.

Vincke G., Kirschvinck, N., Fievez, L., Desmet, C., & Gustin, P. (2004). Repeated cadmium nebulization induces MMP-2 and MMP-9 activation in bronchoalveolar lavage fluid of rats. In Repeated cadmium nebulization induces MMP-2 and MMP-9 activation in bronchoalveolar lavage fluid of rats. Veterinary and Comparative respiratory Society.
Peer reviewed

Fievez, L., Desmet, C., Pajak, B., Gillet, L., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2004). STAT5 promotes granulocyte survival during inflammation. Pflügers Archiv: European Journal of Physiology, 447, 8-24.
Peer Reviewed verified by ORBi

Art, T., Desmet, C., Lekeux, P., De Moffarts, B., Couetil, L., Becker, M., Franck, T., Kohnen, S., Deby-Dupont, G., & Serteyn, D. (2004). Myeloperoxydase concentration in bronchoalveolar lavage from healthy and heavy horses. In Proceedings : 22nd Symposium of the Veterinary and Comparative Respiratory Society (pp. 74-75).
Peer reviewed

Desmet, C., Gosset, P., Pajak, B., Cataldo, D., Bentires-Alj, M., Lekeux, P., & Bureau, F. (2004). Selective blockade of NF-kappaB activity in airway immune cells inhibits the effector phase of experimental asthma [Poster presentation]. 22nd Symposium of the Veterinary and Comparative Respiratory Society, Montréal, Canada.

Fievez, L., Desmet, C., Seumois, G., Pajak, B., Gillet, L., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2004). STAT5 promotes granulocyte survival during lung inflammation. In Proceedings: 22nd Symposium of the Veterinary and Comparative Respiratory Society (pp. 69). Veterinary and Comparative Respiratory Society.
Peer reviewed

Desmet, C., Warsée, B., Mélotte, D., Rongvau, A., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2004). Effects of thiazolidinediones on tumor necrosis factor R alpha induced inflammatory cytokine expression. Pflügers Archiv: European Journal of Physiology, 447, 8-23.
Peer Reviewed verified by ORBi

Desmet, C., Warzée, B., Mélotte, D., Rongvaux, A., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2003). Effects of thiazolidinediones on tumor necrosis factor-α-induced inflammatory cytokine expression [Poster presentation]. Autumn Meeting of the Belgian Society of Fundamental and Clinical Physiology and Pharmacology, Liège, Belgium.

Fievez, L., Desmet, C., Pajak, B., Gillet, L., Vanderplasschen, A., Lekeux, P., & Bureau, F. (2003). STAT5 promotes granulocyte survival during inflammation [Poster presentation]. Autumn Meeting of the Belgian Society of Fundamental and Clinical Physiology and Pharmacology, Liège, Belgium.

Bureau, F.* , Desmet, C.* , Burin Kefer, D., Jaspar, F., VolantI, C., Vanderplasschen, A., Pastoret, P.-P., PiettE, J., & Lekeux, P. (May 2002). A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: Oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition. Journal of Immunology, 168 (10), 5318-5325. doi:10.4049/jimmunol.168.10.5318
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Bureau, F., Gosset, P., Desmet, C., Bentires-Alj, M., Cataldo, D., Desmecht, D., Vanderplasschen, A., Tonnel, A. B., & Lekeux, P. (2002). Local administration of nuclear factor-kB decoy oligodeoxinucleotides prevents allergic airway inflammation. In 12th European Respiratory Society Annual Congress (pp. 170).
Peer reviewed

Desmet, C., Bureau, F., & Lekeux, P. (2002). Nuclear factor-kB activity in human and animal models of inflammation : the case of asthma [Paper presentation]. COST action B20 and COST action 844 joint meeting, Gand, Belgium.

Bureau, F., Desmet, C., Mélotte, C., Jaspar, F., Volanti, C., Vanderplasschen, A., Pastoret, P.-P., Piette, J., & Lekeux, P. (2002). Cyclopentenone prostaglandins at low concetrations exert pro-inflammatory effects through oxidative stress-induced ERK1/2 activation. In Proceedings: Spring Meeting of the Belgian Society of Physiology and Pharmacology.
Peer reviewed

Bureau, F., Desmet, C., Melotte, D., Jaspar, F., Volanti, C., Vanderplasschen, A., Pastoret, P.-P., Piette, J., & Lekeux, P. (2002). A pro-inflammatory role for the cyclopentenone prostaglandins at low concentrations: oxidative stress-induced Erk activation without NF-kB inhibition [Poster presentation]. Cell Signaling, Transcription and Translation as Therapeutic Targets Meeting, Luxembourg.

Bureau, F., Desmet, C., Melotte, D., Jaspar, V., Volanti, C., Vanderplasschen, A., Piette, J., & Lekeux, P. (2002). A pro-inflammatory role for the cyclopentenone prostaglandins at low concentrations: oxidative stress-induced ERK activation without NFKB inhibition. In Proceedings : Congress "Cell signaling, transcription and translation as therapeutics targets" (pp. 75).
Peer reviewed

Desmet, C. (September 2001). NF-κB-dependent cytokine production is abolished by cyclopentenone prostaglandins in lung epithelial cells [Paper presentation]. European Respiratory Symposium, Berlin, Germany.

Desmet, C., Fievez, L., Lekeux, P., & Bureau, F. (2001). Cyclopenone prostaglandins inhibit NF-κB activity and inflammatory gene expression in lung epithelial cells. In World Equine Airways Symposium (pp. 61). World Equine Airways Symposium editor.
Peer reviewed

Bureau, F., Seumois, G., Jaspar, F., Desmet, C., Louis, K., & Lekeux, P. (2001). Expression of c-inhibitor of apoptosis protein-2 in the sputum from asthmatic patients. In Proceedings : 11th European Respiratory Society Annual Congress, Eur. Respir. J., 2001, 18 (Suppl. 33) (pp. 531).
Peer reviewed

Desmet, C., Fievez, L., LOUIS, R., Lekeux, P., & Bureau, F. (2001). NF-kappaB-dependent cytokine production is abolished by cyclopentenone prostaglandins in lung epithelial cells. European Respiratory Journal. Supplement, 18, 354.
Peer Reviewed verified by ORBi

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