Article (Scientific journals)
Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
CHARLIER, Edith; RELIC, Biserka; Deroyer, Céline et al.
2016In International Journal of Molecular Sciences
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Keywords :
osteoarthritis; chondrocytes; apoptosis
Abstract :
[en] Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of empty lacunae and hypocellularity in cartilage with aging and OA progression, suggesting that chondrocyte cell death occurs and participates to OA development. However, the relative contribution of apoptosis per se in OA pathogenesis appears complex to evaluate. Indeed, depending on technical approaches, OA stages, cartilage layers, animal models, as well as in vivo or in vitro experiments, the percentage of apoptosis and cell death types can vary. Apoptosis, chondroptosis, necrosis, and autophagic cell death are described in this review. The question of cell death causality in OA progression is also addressed, as well as the molecular pathways leading to cell death in response to the following inducers: Fas, Interleukin-1 (IL-1 ), Tumor Necrosis factor- (TNF- ), leptin, nitric oxide (NO) donors, and mechanical stresses. Furthermore, the protective role of autophagy in chondrocytes is highlighted, as well as its decline during OA progression, enhancing chondrocyte cell death; the transition being mainly controlled by HIF-1 /HIF-2 imbalance. Finally, we have considered whether interfering in chondrocyte apoptosis or promoting autophagy could constitute therapeutic strategies to impede OA progression.
Disciplines :
Biochemistry, biophysics & molecular biology
Rheumatology
Author, co-author :
CHARLIER, Edith ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
RELIC, Biserka ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
Deroyer, Céline  ;  Université de Liège > Département des sciences cliniques > Rhumatologie
MALAISE, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
NEUVILLE, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
Collée, Julie  
MALAISE, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
DE SENY, Dominique ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
Language :
English
Title :
Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
Publication date :
20 December 2016
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Molecular Diversity Preservation International (MDPI), Basel, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 January 2017

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