Profil

de Seny Dominique

Département des sciences biomédicales et précliniques

See author's contact details
Main Referenced Co-authors
Malaise, Michel  (70)
Malaise, Olivier  (45)
Charlier, Edith  (34)
Deroyer, Céline  (31)
Neuville, Sophie  (31)
Main Referenced Keywords
Humans (7); Osteoarthritis (5); Adult (4); biomarkers (4); Female (4);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (5)
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège [BE] (1)
Laboratory of Rheumatology, GIGA Research, University of Liège, CHU Liège, Liège, Belgium (1)
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE] (1)
Main Referenced Disciplines
Rheumatology (59)
Biochemistry, biophysics & molecular biology (17)
Pharmacy, pharmacology & toxicology (12)
Gastroenterology & hepatology (5)
Radiology, nuclear medicine & imaging (3)

Publications (total 87)

The most downloaded
433 downloads
Meuwis, M.-A.* , Fillet, M.* , Geurts, P., De Seny, D., Lutteri, L., Chapelle, J.-P., Bours, V., Wehenkel, L., Belaiche, J., Malaise, M., Louis, E., & Merville, M.-P. (2007). Biomarker discovery for inflammatory bowel disease, using proteomic serum profiling. Biochemical Pharmacology, 73 (9), 1422-1433. doi:10.1016/j.bcp.2006.12.019 https://hdl.handle.net/2268/26590

The most cited

270 citations (Scopus®)

Charlier, E., DEROYER, C., Ciregia, F., MALAISE, O., NEUVILLE, S., PLENER, Z., Malaise, M., & de Seny, D. (2019). Chondrocyte dedifferentiation and osteoarthritis (OA). Biochemical Pharmacology, 165, 49-65. doi:10.1016/j.bcp.2019.02.036 https://hdl.handle.net/2268/263525

Nix, C., Sulejman, S., Cobraiville, G., Njock, M.-S., Paulissen, G., de Seny, D., & Fillet, M. (2024). Development of complementary analytical methods to characterize extracellular vesicles [Paper presentation]. CIRM Day, Liege, Belgium.

Fusi, G., Constantinides, M., Fissoun, C., Pichard, L., Pers, Y.-M., Ferreira-Lopez, R., Pantesco, V., Poulet, C., Malaise, O., de Seny, D., Lemaitre, J.-M., Jorgensen, C., & Brondello, J.-M. (14 July 2023). Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients. Biomedicines, 11 (7), 1994. doi:10.3390/biomedicines11071994
Peer Reviewed verified by ORBi

Nix, C., Ciregia Frederica, Cobraiville, G., de Seny, D., & Fillet, M. (24 May 2023). Microfluidic liquid chromatography coupled to drift-tube ion mobility and high-resolution mass spectrometry for the analysis of fibroblast-like synoviocytes stimulated with SAA variants [Paper presentation]. 39th International Symposium on Microscale Separation and Bioanalysis (MSB), Tallahassee, United States.
Peer reviewed

Nix, C., Ciregia, F., Cobraiville, G., de Seny, D., & Fillet, M. (01 February 2023). Micropillar array column coupled to drift-tube ion mobility and mass spectrometry for the analysis of fibroblast-like synoviocytes [Paper presentation]. CIRM Day, Liege, Belgium.

Nix, C., Nys, G., Cobraiville, G., de Seny, D., & Fillet, M. (11 September 2022). Quantification of serum amyloid A variants in plasma, synovial fluid and cell culture medium to better understand rheumatoid arthritis [Poster presentation]. 12th International Symposium on Drug Analysis and the 32nd International Symposium on Pharmaceutical and Biomedical Analysis (DA-PBA 2022, Mons, Belgium.
Peer reviewed

DEROYER, C., Poulet, C., PAULISSEN, G., Ciregia, F., MALAISE, O., PLENER, Z., COBRAIVILLE, G., DANIEL, C., GILLET, P., MALAISE, M., & DE SENY, D. (2022). CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane. Cellular and Molecular Life Sciences. doi:10.1007/s00018-022-04282-6
Peer Reviewed verified by ORBi

DE SENY, D., Baiwir, D., BIANCHI, E., COBRAIVILLE, G., DEROYER, C., Poulet, C., MALAISE, O., PAULISSEN, G., KAISER, M.-J., Hauzer, J.-P., Mazzucchelli, G., DELVENNE, P., & MALAISE, M. (2022). New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases. International Journal of Molecular Sciences, 23 (1), 434. doi:10.3390/ijms23010434
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Papagiannopoulos, O. D., Papaloukas, C., Pezoulas, V. C., Van De Werken, H. J. G., Poulet, C., Mueller, Y. M., Katsikis, P. D., de Seny, D., & Fotiadis, D. I. (2022). Comparison of Proteomic Approaches in Autoinflammatory Disease Classification. In BHI-BSN 2022 - IEEE-EMBS International Conference on Biomedical and Health Informatics and IEEE-EMBS International Conference on Wearable and Implantable Body Sensor Networks, Symposium Proceedings. Institute of Electrical and Electronics Engineers Inc. doi:10.1109/BHI56158.2022.9926877
Editorial reviewed

MALAISE, O., PAULISSEN, G., DEROYER, C., Cirgea, F., Poulet, C., LECHANTEUR, C., Brondello, J.-M., DE SENY, D., & MALAISE, M. (December 2021). Influence des glucocorticoïdes sur les caractéristiques de la sénescence cellulaire dans les fibroblastes synoviaux d’origine arthrosique. Revue du Rhumatisme, 88 (S1), 157.
Peer reviewed

MALAISE, O.* , PAULISSEN, G.* , DEROYER, C., Ciregia, F., Poulet, C., NEUVILLE, S., PLENER, Z., DANIEL, C., Gillet, P., LECHANTEUR, C., Brondello, J.-M., DE SENY, D.* , & MALAISE, M.*. (16 November 2021). Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes. Journal of Clinical Medicine, 10 (22), 5331. doi:10.3390/jcm10225331
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

CIREGIA, F., Nys, G., Cobraiville, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Fillet, M., Malaise, M., & de Seny, D. (2021). A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis. Frontiers in Immunology. doi:10.3389/fimmu.2021.638814
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JACQUERIE, P., HENKET, M., André, B., MOERMANS, C., DE SENY, D., GESTER, F., LOUIS, R., MALAISE, M., & GUIOT, J. (21 May 2021). Inflammatory profile of induced sputum composition in systemic sclerosis and comparison with healthy volunteers. Scientific Reports, 11 (1), 10679. doi:10.1038/s41598-021-87701-1
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Ciregia, F., DEROYER, C., COBRAIVILLE, G., PLENER, Z., MALAISE, O., GILLET, P., Fillet, M., MALAISE, M., & DE SENY, D. (2021). Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN (381-397 a.a.) competing for TGF-β1 activation. Experimental and Molecular Medicine. doi:10.1038/s12276-021-00558-2
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DEROYER, C., CIREGIA, F., MALAISE, O., PAULISSEN, G., Poulet, C., Malaise, M., & DE SENY, D. (2021). Fibrosis in osteoarthritis – Role of Cemip [Paper presentation]. Fibrosis in immune-mediated inflammatory diseases : from pathophysiology to innovative treatment.

GUIOT, J., NJOCK, M.-S., ANDRE, B., GESTER, F., HENKET, M., DE SENY, D., MOERMANS, C., MALAISE, M., & LOUIS, R. (2021). Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction. Scientific Reports, 11 (1), 10882. doi:10.1038/s41598-021-90333-0
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RELIC, B., DEROYER, C., MALAISE, O., Plener, Z., Gillet, P., de Seny, D., & Malaise, M. (2021). TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. Biochemical Journal, 478 (16), 3145-3155. doi:10.1042/BCJ20210174
Peer Reviewed verified by ORBi

MALAISE, O., DE SENY, D., & RINKIN, C. (2020). Polyarthrite rhumatoïde : le CHU de Liège à la pointe de la recherche et de l'innovation. La Libre Belgique.

CIREGIA, F., Nys, G., COBRAIVILLE, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Fillet, M., Malaise, M., & DE SENY, D. (December 2020). Caractérisation de l’expression des alarmines et des variants A-SAA dans la polyarthrite rhumatoïde débutante. Revue du Rhumatisme, 87 (S1), 126. doi:10.1016/j.rhum.2020.10.218
Peer reviewed

DE SENY, D., BIANCHI, E., Baiwir, D., COBRAIVILLE, G., Collin, C., Deliège, M., KAISER, M.-J., Mazzucchelli, G., Hauzeur, J.-P., DELVENNE, P., & MALAISE, M. (May 2020). Proteins involved in the endoplasmic reticulum stress are key players in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score [Poster presentation]. OARSI, Vienna, Austria.

de Seny, D., Bianchi, E., Baiwir, D., COBRAIVILLE, G., Collin, C., Deliège, M., Kaiser, M.-J., Mazzucchelli, G., Hauzeur, J.-P., Delvenne, P., & Malaise, M. (2020). Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score. Scientific Reports, 10 (1). doi:10.1038/s41598-020-70803-7
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Ciregia, F., Baiwir, D., COBRAIVILLE, G., DEWAEL, T., Mazzucchelli, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Malaise, M., & de Seny, D. (2020). Glycosylation deficiency of lipopolysaccharide-binding protein and corticosteroid-binding globulin associated with activity and response to treatment for rheumatoid arthritis. Journal of Translational Medicine, 18 (1). doi:10.1186/s12967-019-02188-9
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CHARLIER, E.* , DEROYER, C.* , NEUVILLE, S., Plener, Z., MALAISE, O., Ciregia, F., Gillet, P., Reuter, G., Salvé, M., Withofs, N., Hustinx, R., de Seny, D., & Malaise, M. (2020). Toward diagnostic relevance of the α(V)β(5), α(V)β(3), and α(V)β(6) integrins in OA: expression within human cartilage and spinal osteophytes. Bone Research, 8, 35. doi:10.1038/s41413-020-00110-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

CIREGIA, F., Baiwir, D., COBRAIVILLE, G., DEWAEL, T., Mazzucchelli, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Malaise, M., & DE SENY, D. (09 December 2019). Le déficit de la N-glycosylation de la corticosteroid–binding globulin et de la lipopolysaccharide–binding protein est associé à l'activité de la maladie et à la réponse au traitement dans la polyarthrite rhumatoïde [Paper presentation]. 32ème Congrès Français de Rhumatologie, Paris, France.

DE SENY, D., BIANCHI, E., Baiwir, D., Mazzucchelli, G., DEROYER, C., CIREGIA, F., MALAISE, O., KAISER, M.-J., Hauzeur, J.-P., DELVENNE, P., & MALAISE, M. (09 December 2019). La protéomique synoviale identifie de nouvelles protéines corrélées au score inflammatoire histologique : comparaison entre arthrose, chondrocalcinose et polyarthrite rhumatöide [Paper presentation]. 32ème Congrès Français de Rhumatologie, Paris, France.

Nys, G., COBRAIVILLE, G., Servais, A.-C., Malaise, M., DE SENY, D., & Fillet, M. (2019). Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis. Talanta. doi:10.1016/j.talanta.2019.06.044
Peer reviewed

Vaamonde-Garcia, C., MALAISE, O., CHARLIER, E., DEROYER, C., NEUVILLE, S., GILLET, P., Kurth, W., Meijide-Failde, R., MALAISE, M., & DE SENY, D. (2019). 15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts. Biochemical Pharmacology. doi:10.1016/j.bcp.2019.03.039
Peer Reviewed verified by ORBi

MALAISE, O., & DE SENY, D. (2019). Therapeutic advances in arthritis diseases. Biochemical Pharmacology. doi:10.1016/j.bcp.2019.04.014
Peer Reviewed verified by ORBi

Charlier, E., NEUVILLE, S., PLENER, Z., DEROYER, C., RELIC, B., MALAISE, O., REUTER, G., GILLET, P., Salvé, M., WITHOFS, N., HUSTINX, R., DE SENY, D., & MALAISE, M. (May 2019). EXPRESSION OF αVβ5, αVβ3 AND β6 INTEGRINS BY OSTEOARTHRITIC CHONDROCYTES AND VERTEBRAL OSTEOPHYTES [Poster presentation]. OARSI, Toronto, Canada.

DE SENY, D., DEROYER, C., Charlier, E., CIREGIA, F., COBRAIVILLE, G., MEUWIS, M.-A., LOUIS, E., Fillet, M., & MALAISE, M. (May 2019). Increased serological levels of vitronectin(amino acid 381-397) and C3f peptides in osteoarthritis, lupus and scleroderma. Interaction with TGF-β [Poster presentation]. OARSI, Toronto, Canada.

DEROYER, C., Charlier, E., NEUVILLE, S., MALAISE, O., MALAISE, M., & DE SENY, D. (May 2019). CEMIP (KIAA1199) induces a fibrosis-like process in OA chondrocytes [Poster presentation]. OARSI 2019, Toronto, Canada.

DEROYER, C., CHARLIER, E., NEUVILLE, S., MALAISE, O., GILLET, P., KURTH, W., Chariot, A., MALAISE, M., & DE SENY, D. (2019). CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes. Cell Death and Disease. doi:10.1038/s41419-019-1377-8
Peer Reviewed verified by ORBi

Charlier, E., DEROYER, C., Ciregia, F., MALAISE, O., NEUVILLE, S., PLENER, Z., Malaise, M., & de Seny, D. (2019). Chondrocyte dedifferentiation and osteoarthritis (OA). Biochemical Pharmacology, 165, 49-65. doi:10.1016/j.bcp.2019.02.036
Peer Reviewed verified by ORBi

BONHOMME, O., ANDRE, B., GESTER, F., DE SENY, D., MOERMANS, C., Struman, I., Louis, R., MALAISE, M., & GUIOT, J. (2019). Biomarkers in systemic sclerosis-associated interstitial lung disease: review of the literature. Rheumatology (Oxford, England). doi:10.1093/rheumatology/kez230
Peer reviewed

DEROYER, C., Charlier, E., Malaise, O., Malaise, M., & DE SENY, D. (10 December 2018). CEMIP accompagne l’expression de marqueurs de fibrose par le cartilage et la synoviale arthrosique [Poster presentation]. 31e congrès français de rhumatologie, Paris, France.

DE SENY, D., COBRAIVILLE, G., DEROYER, C., MEUWIS, M.-A., LOUIS, E., Fillet, M., & MALAISE, M. (10 December 2018). Elévation des taux sériques des peptides C3f et vitronectine (acide aminés 381-397) dans l’arthrose, le lupus et la sclérodermie. Interaction avec le TGF-β [Poster presentation]. 31ème Congrès Français de Rhumatologie, Paris, France.

CHARLIER, E., NEUVILLE, S., RELIC, B., DEROYER, C., MALAISE, O., KURTH, W., GILLET, P., DE SENY, D., & MALAISE, M. (April 2018). Regulation of α5 and β1 integrin expression by osteogenic or adipogenic differentiation as well as by TGFβ in human hip OA chondrocytes [Poster presentation]. 2018 World Congress on Osteoarthritis.

Fosse, P., KAISER, M.-J., Namur, G., DE SENY, D., Malaise, M., & Hustinx, R. (2018). (18)F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab. European Journal of Hybrid Imaging, 2 (1), 6. doi:10.1186/s41824-017-0022-y
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RELIC, B., CHARLIER, A., DEROYER, C., MALAISE, O., Crine, Y., NEUVILLE, S., GILLET, P., DE SENY, D., & Malaise, M. (2018). Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death. Oncotarget, 9 (88), 35830-35843. doi:10.18632/oncotarget.26295
Peer Reviewed verified by ORBi

DEROYER, C., Charlier, E., NEUVILLE, S., MALAISE, O., Malaise, M., & DE SENY, D. (2018). CEMIP induces a fibrosis-like process in OA chondrocytes [Poster presentation]. OARSI 2018.

CHARLIER, E., NEUVILLE, S., RELIC, B., DEROYER, C., MALAISE, O., KURTH, W., GILLET, P., DE SENY, D., & MALAISE, M. (10 December 2017). Régulation de l’expression des intégrines a5 et ß1 par la différenciation ostéogénique ou adipogénique ainsi que par le TGFß dans les chondrocytes humains arthrosiques de hanche [Paper presentation]. 30ème Congrès Français de Rhumatologie.

DE SENY, D., Baiwir, D., Collin, C., Deliège, M., DELVENNE, P., De Pauw, E., Hauzeur, J.-P., & MALAISE, M. (10 December 2017). Analyse protéomique de biopsies synoviales: comparaison entre arthrose, arthrose avec chondrocalcinose et polyarthrite rhumatoïde [Paper presentation]. 30ème Congrès Français de Rhumatologie, Paris, France.

DEROYER, C., Charlier, E., Malaise, O., MALAISE, M., & DE SENY, D. (10 December 2017). Rôle de KIAA1199 dans le développement de l’arthrose [Paper presentation]. 30e congrès français de rhumatologie, Paris, France.

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Nys, G., COBRAIVILLE, G., DE SENY, D., & Fillet, M. (14 November 2017). Targeted analysis of potential biomarkers of rheumatoid arthritis by LC-MS/MS [Paper presentation]. CIRM seminar, Liège, Belgium.

DEROYER, C., NEUVILLE, S., Charlier, E., MALAISE, O., MALAISE, M., & DE SENY, D. (28 April 2017). Role of KIAA1199 in osteoarthritic cartilage degradation [Poster presentation]. OARSI 2017.

CHARLIER, E., NEUVILLE, S., RELIC, B., DEROYER, C., MALAISE, O., KURTH, W., GILLET, P., WITHOFS, N., HUSTINX, R., DE SENY, D., & MALAISE, M. (April 2017). Regulation of αVβ3 and αVβ5 integrin complexes by osteogenic differentiation of human hip OA chondrocytes [Poster presentation]. 2017 World Congress on Osteoarthritis.

COBRAIVILLE, G., Fillet, M., Sharif, M., Ourradi, K., Nys, G., Malaise, M., & DE SENY, D. (2017). Validation of a new method by nano-liquid chromatography on chip tandem mass spectrometry for combined quantitation of C3f and the V65 vitronectin fragment as biomarkers of diagnosis and severity of osteoarthritis. Talanta, 169, 170-180. doi:10.1016/j.talanta.2017.03.078
Peer Reviewed verified by ORBi

Ourradi, K., Xu, Y., DE SENY, D., Kirwan, J., Blom, A., & Sharif, M. (2017). Development and validation of novel biomarker assays for osteoarthritis. PLoS ONE, 12 (7), 0181334. doi:10.1371/journal.pone.0181334
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CHARLIER, E., RELIC, B., Deroyer, C., MALAISE, O., NEUVILLE, S., Collée, J., MALAISE, M., & DE SENY, D. (2016). Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis. International Journal of Molecular Sciences. doi:10.3390/ijms17122146
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DE SENY, D., COBRAIVILLE, G., Leprince, P., Fillet, M., Collin, C., Mathieu, M., HAUZEUR, J.-P., Gangji, V., & Malaise, M. (2016). Biomarkers of inflammation and innate immunity in atrophic nonunion fracture. Journal of Translational Medicine. doi:10.1186/s12967-016-1019-1
Peer Reviewed verified by ORBi

RELIC, B., CHARLIER, E., Deroyer, C., MALAISE, O., NEUVILLE, S., Desoroux A, Gillet, P., DE SENY, D., & Malaise, M. (26 April 2016). BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death. Oncotarget, 7 (17), 23370-82. doi:10.18632/oncotarget.8042
Peer Reviewed verified by ORBi

Charlier, E., DEROYER, C., MALAISE, O., NEUVILLE, S., COBRAIVILLE, G., GILLET, P., KURTH, W., DE SENY, D., & MALAISE, M. (01 April 2016). Insights into the role of Dickkopf 3 (Dkk3) on Wnt/β-catenin and TGFβ ALK1/Smad1/5 signaling pathways as well as on leptin production during human hip OA chondrocytes dedifferentiation [Poster presentation]. OARSI 2016.

CHARLIER, E., MALAISE, O., Deroyer, C., Zeddou, M., NEUVILLE, S., COBRAIVILLE, G., Gillet, P., KURTH, W., De Seny, D., RELIC, B., & Malaise, M. (April 2016). Dickkopf 3 (Dkk3) is increased along human hip OA chondrocytes dedifferentiation and can modulate Wnt/Β-catenin and TGFβ Alk1/Smad1/5 signaling pathways, as well as leptin production [Poster presentation]. OARSI 2016 world congress.

MALAISE, O., RELIC, B., Charlier, E., Zeddou, M., NEUVILLE, S., Deroyer, C., Gillet, P., Louis, E., Malaise, M., & DE SENY, D. (2016). Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Arthritis Research and Therapy, 18 (1), 219. doi:10.1186/s13075-016-1119-6
Peer Reviewed verified by ORBi

CHARLIER, E.* , MALAISE, O.* , Zeddou, M., NEUVILLE, S., COBRAIVILLE, G., DEROYER, C., Sanchez, C., Gillet, P., KURTH, W., DE SENY, D., RELIC, B., & MALAISE, M. (2016). Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and b-catenin activation. Osteoarthritis and Cartilage. doi:10.1016/j.joca.2015.08.002
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

DE SENY, D., COBRAIVILLE, G., CHARLIER, E., NEUVILLE, S., LUTTERI, L., LE GOFF, C., MALAISE, D., MALAISE, O., CHAPELLE, J.-P., RELIC, B., & MALAISE, M. (2015). Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties. PLoS ONE. doi:10.1371/journal.pone.0122904
Peer Reviewed verified by ORBi

WITHOFS, N., CHARLIER, E., Simoni, P., Alvarez-Miezentseva, V., Mievis, F., Giacomelli, F., Mella, C., Gambhir, S. S., Malaise, O., DE SENY, D., MALAISE, M., & HUSTINX, R. (2015). (18)F-FPRGD2 PET/CT imaging of musculoskeletal disorders. Annals of Nuclear Medicine, 29 (10), 839-47. doi:10.1007/s12149-015-1011-5
Peer Reviewed verified by ORBi

MALAISE, O., RELIC, B., QUESADA CALVO, F., Charlier, E., Zeddou, M., NEUVILLE, S., Gillet, P., Louis, E., DE SENY, D., & MALAISE, M. (2015). Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. Rheumatology. doi:10.1093/rheumatology/keu428
Peer Reviewed verified by ORBi

MALAISE, O., RELIC, B., NEUVILLE, S., CHARLIER, E., DE SENY, D., & MALAISE, M. (08 December 2014). GILZ (Glucocorticoid-Induced Leuzine Zipper) est un intermédiaire de l’action des corticoïdes sur les cellules arthrosiques : implication dans la sécrétion de leptine et l’expression de son récepteur, mais pas dans les effets anti-inflammatoires [Paper presentation]. Congrès de la Société Française de Rhumatologie.

MALAISE, O., RELIC, B., NEUVILLE, S., CHARLIER, E., DE SENY, D., & Malaise, M. (24 September 2014). Leptin production by osteoarthritic synovial fibroblasts [Paper presentation]. Congrès de la Société Belge de Rhumatologie.

MALAISE, O., RELIC, B., NEUVILLE, S., Charlier, E., DE SENY, D., & MALAISE, M. (September 2014). Leptin production by osteoarthritis synovial fibroblasts: stimulation by glucocorticoids and mineralocorticoids through the glucocorticoid receptor and GILZ (Glucocorticoid-Induced Leucine Zipper) protein [Paper presentation]. Belgian Congress of Rheumatology, 2014.
Peer reviewed

De Bock, M., BEGUIN, Y., Leprince, P., WILLEMS, E., BARON, F., Deroyer, C., Seidel, L., CAVALIER, E., DE SENY, D., MALAISE, M., GOTHOT, A., MERVILLE, M.-P., & Fillet, M. (July 2014). Comprehensive plasma profiling for the characterization of graft-versus-host disease biomarkers. Talanta, 125, 265-275. doi:10.1016/j.talanta.2014.03.017
Peer Reviewed verified by ORBi

MALAISE, O., RELIC, B., NEUVILLE, S., CHARLIER, E., DE SENY, D., & MALAISE, M. (2014). Leptin Production By Osteoarthritis Synovial Fibroblasts: Stimulation By Glucocorticoids and Mineralocorticoids through the Glucocorticoid Receptor and GILZ (Glucocorticoid-Induced Leucine Zipper) Protein. Arthritis and Rheumatism, 66 (11), 454.
Peer Reviewed verified by ORBi

MALAISE, O., RELIC, B., NEUVILLE, S., CHARLIER, E., DE SENY, D., & Malaise, M. (2014). The glucocorticoid-induced leucine zipper (GILZ) is involved in corticosteroid-induced leptin production by human osteoarthritis synovial fibroblasts in vitro. Osteoarthritis and Cartilage, 22, 449-450.
Peer Reviewed verified by ORBi

DE SENY, D., COBRAIVILLE, G., CHARLIER, E., NEUVILLE, S., Esser, N., MALAISE, D., MALAISE, O., Calvo, F., RELIC, B., & MALAISE, M. (2013). Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties. PLoS ONE. doi:10.1371/journal.pone.0066769
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MALAISE, O., RELIC, B., CHARLIER, E., zeddou, M., QUESADA-CALVO, F., NEUVILLE, S., DE SENY, D., & MALAISE, M. (2013). Compound A, un modulateur du récepteur aux glucocorticoïdes, ne stimule la production de leptine ni chez les fibroblastes synoviaux humains d’origine arthrosique, ni chez les chondrocytes dédifférenciés humains. Revue du Rhumatisme, 80 (1), 352.
Peer Reviewed verified by ORBi

MALAISE, O., RELIC, B., CHARLIER, E., Zeddou, M., QUESADA-CALVO, F., NEUVILLE, S., DE SENY, D., & Malaise, M. (2013). Glucocorticoid receptor modulator Compound A does not induce leptin in human osteoarthritic synovial fibroblasts and in dedifferentiated chondrocytes. Arthritis and Rheumatism, 65 (10), 55.
Peer Reviewed verified by ORBi

MALAISE, O., RELIC, B., CHARLIER, E., Zeddou, M., QUESADA-CALVO, F., NEUVILLE, S., DE SENY, D., & MALAISE, M. (2012). Human chondrocyte dedifferentiation is accompagnied by CD105 endoglin expression, ALK-1/Smad1/5 phosphorylation and leptin production – Stimulation by prednisolone and aldosterone through the glucocorticoid receptor. Arthritis and Rheumatism, 64 (10), 50.
Peer Reviewed verified by ORBi

MALAISE, O.* , RELIC, B.* , CHARLIER, E., Zeddou, M., QUESADA-CALVO, F., NEUVILLE, S., DE SENY, D., & MALAISE, M. (2012). Les minéralocorticoïdes (aldostérone) stimulent la production de leptine des fibroblastes synoviaux d'origine arthrosique : implication du récepteur aux glucocorticoïdes, mais pas du récepteur aux minéralocorticoïdes. Revue du Rhumatisme, 79, 352.
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Zeddou, M., RELIC, B., MALAISE, O., CHARLIER, E., Desouroux, A., BEGUIN, Y., DE SENY, D., & Malaise, M. (2012). Differential signalling through ALK-1 and ALK-5 regulates leptin expression in Mesenchymal Stem Cells. Stem Cells and Development, 21 (11), 1948-54. doi:10.1089/scd.2011.0321
Peer Reviewed verified by ORBi

DE SENY, D., Sharif, M., Fillet, M., COBRAIVILLE, G., Meuwis, M.-A., Marée, R., HAUZEUR, J.-P., Wehenkel, L., Louis, E., Merville, M.-P., Kirwan, J., Ribbens, C., & Malaise, M. (2011). Discovery and biochemical characterisation of four novel biomarkers for osteoarthritis. Annals of the Rheumatic Diseases, 70 (6), 1144-52. doi:10.1136/ard.2010.135541
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De Bock, M., De Seny, D., Meuwis, M.-A., Servais, A.-C., Minh, T. Q., Closset, J., Chapelle, J.-P., Louis, E., Malaise, M., Merville, M.-P., & Fillet, M. (2010). Comparison of three methods for fractionation and enrichment of low molecular weight proteins for SELDI-TOF-MS differential analysis. Talanta, 82, 245-254. doi:10.1016/j.talanta.2010.04.029
Peer Reviewed verified by ORBi

De Seny, D., Ribbens, C., Cobraiville, G., Meuwis, M.-A., Marée, R., Geurts, P., Wehenkel, L., Louis, E., Merville, M.-P., Fillet, M., & Malaise, M. (2009). Protéomique par SELDI-TOF-MS des maladies inflammatoires articulaires: identification des protéines S100 comme protéines d'intérêt. Revue Médicale de Liège, 64 (Spec No), 29-35.
Peer reviewed

Relic, B., Zeddou, M., Desoroux, A., Beguin, Y., De Seny, D., & Malaise, M. (2009). Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. Laboratory Investigation, 89 (7), 811-822. doi:10.1038/labinvest.2009.41
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De Bock, M., De Seny, D., Meuwis, M.-A., Chapelle, J.-P., Louis, E., Malaise, M., Merville, M.-P., & Fillet, M. (2009). Challenges for Biomarker Discovery in Body Fluids Using SELDI-TOF-MS. Journal of Biomedicine and Biotechnology. doi:10.1155/2010/906082
Peer Reviewed verified by ORBi

Quesada Calvo, F.* , Fillet, M.* , De Seny, D., Meuwis, M.-A., Marée, R., Crahay, C., Paulissen, G., Rocks, N., Guéders, M., Wehenkel, L., Merville, M.-P., Louis, R., Foidart, J.-M., Noël, A., & Cataldo, D. (2009). Biomarker discovery in asthma-related inflammation and remodeling. Proteomics, 9 (8), 2163-2170. doi:10.1002/pmic.200800643
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

De Seny, D., Fillet, M., Ribbens, C., Marée, R., Meuwis, M.-A., Lutteri, L., Chapelle, J.-P., Wehenkel, L., Louis, E., Merville, M.-P., & Malaise, M. (2008). Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis. Clinical Chemistry, 54, 1066-1075. doi:10.1373/clinchem.2007.099549
Peer Reviewed verified by ORBi

Meuwis, M.-A.* , Fillet, M.* , Lutteri, L., Marée, R., Geurts, P., De Seny, D., Malaise, M., Chapelle, J.-P., Wehenkel, L., Belaiche, J., Merville, M.-P., & Louis, E. (2008). Proteomics for prediction and characterization of response to infliximab in Crohn's disease: a pilot study. Clinical Biochemistry, 41 (12), 960-7. doi:10.1016/j.clinbiochem.2008.04.021
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Meuwis, M.-A.* , Fillet, M.* , Geurts, P., De Seny, D., Lutteri, L., Chapelle, J.-P., Bours, V., Wehenkel, L., Belaiche, J., Malaise, M., Louis, E., & Merville, M.-P. (2007). Biomarker discovery for inflammatory bowel disease, using proteomic serum profiling. Biochemical Pharmacology, 73 (9), 1422-1433. doi:10.1016/j.bcp.2006.12.019
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

De Seny, D.* , Fillet, M.* , Meuwis, M.-A., Geurts, P., Lutteri, L., Ribbens, C., Bours, V., Wehenkel, L., Piette, J., Malaise, M., & Merville, M.-P. (2005). Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach. Arthritis and Rheumatism, 52 (12), 3801-12. doi:10.1002/art.21607
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Geurts, P., Fillet, M., De Seny, D., Meuwis, M.-A., Malaise, M., Merville, M.-P., & Wehenkel, L. (2005). Proteomic mass spectra classification using decision tree based ensemble methods. Bioinformatics, 21 (14), 3138-45. doi:10.1093/bioinformatics/bti494
Peer Reviewed verified by ORBi

De Seny, D., Fillet, M., Meuwis, M.-A., Lutteri, L., Geurts, P., Wehenkel, L., Bours, V., Piette, J., Malaise, M., & Merville, M.-P. (September 2004). Discovery of new rheumatoid arthritis biomarkers using SELDI-TOF-MS ProteinChip approach. Arthritis and Rheumatism, 50 (9, Suppl. S), 124.

Prosperi, C., De Seny, D., Llabres, G., Galleni, M., & Lamotte-Brasseur, J. (December 2002). Active-site mutants of class B beta-lactamases: substrate binding and mechanistic study. Cellular and Molecular Life Sciences, 59 (12), 2136-2143. doi:10.1007/s000180200013
Peer Reviewed verified by ORBi

De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687
Peer Reviewed verified by ORBi

De Seny, D., Heinz, U., Wommer, S., Kiefer, M., Meyer-Klaucke, W., Galleni, M., Frère, J.-M., Bauer, R., & Adolph, H. W. (30 November 2001). Metal Ion Binding and Coordination Geometry for Wild Type and Mutants of Metallo-Beta -Lactamase from Bacillus Cereus 569/H/9 (Bcii): A Combined Thermodynamic, Kinetic, and Spectroscopic Approach. Journal of Biological Chemistry, 276 (48), 45065-78. doi:10.1074/jbc.M106447200
Peer Reviewed verified by ORBi

Prosperi, C., Llabres, G., De Seny, D., Soto, R. P., Valladares, M. H., Laraki, N., Frère, J.-M., & Galleni, M. (25 January 1999). Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases. FEBS Letters, 443 (2), 109-11. doi:10.1016/S0014-5793(98)01689-5
Peer Reviewed verified by ORBi

Paul-Soto, R., Bauer, R., Frère, J.-M., Galleni, M., Meyer-Klaucke, W., Nolting, H., Rossolini, G. M., DE SENY, D., Hernandez-Valladares, M., Zeppezauer, M., & Adolph, H. W. (1999). Mono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism. Journal of Biological Chemistry, 274 (19), 13242-9. doi:10.1074/jbc.274.19.13242
Peer Reviewed verified by ORBi

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