Reference : The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic prog...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/198458
The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
English
Rambout, Xavier [Université de Liège > > GIGA-Research >]
Detiffe, Cecile [> >]
Bruyr, Jonathan [> >]
Mariavelle, Emeline [> >]
Cherkaoui, Majid [> >]
Brohee, Sylvain [> >]
Demoitie, Pauline [> >]
Lebrun, Marielle [Université de Liège > Département des sciences de la vie > GIGA-R : Virologie et immunologie > > >]
Soin, Romuald [> >]
Lesage, Bart [> >]
Guedri, Katia [Université de Liège > Département des sciences de la vie > Génétique et biologie moléculaires animales >]
Beullens, Monique [> >]
Bollen, Mathieu [> >]
Farazi, Thalia A. [> >]
Kettmann, Richard [Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc. >]
Struman, Ingrid [Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Hill, David E. [> >]
Vidal, Marc [> >]
Kruys, Veronique [> >]
Simonis, Nicolas [> >]
Twizere, Jean-Claude [Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc. >]
Dequiedt, Franck mailto [Université de Liège > > GIGA-Research >]
2016
Nature Structural and Molecular Biology
Nature Publishing Group
Yes (verified by ORBi)
International
1545-9993
1545-9985
[en] RNA ; Decay ; deadenylation
[en] Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical transcription factors whose previously described functions are confined to the control of mRNA synthesis. Here, we report that ERG also regulates gene expression by affecting mRNA stability and identify the molecular mechanisms underlying this function in human cells. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. Transcriptome-wide mRNA stability analysis revealed that ERG controls the degradation of a subset of mRNAs highly connected to Aurora signaling, whose decay during S phase is necessary for mitotic progression. Our data indicate that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, integrating mRNA synthesis and degradation.
Researchers ; Professionals
http://hdl.handle.net/2268/198458
http://reflexions.ulg.ac.be/en/GeneExpression
http://reflexions.ulg.ac.be/en/Wireworms

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