Profil

Twizere Jean-Claude

Département GxABT > Microbial technologies

Département GxABT

See author's contact details
ORCID
0000-0002-8683-705X
Main Referenced Co-authors
Dequiedt, Franck  (34)
Kettmann, Richard  (22)
Vidal, Marc (17)
Willems, Luc  (15)
Hanson, Julien  (12)
Main Referenced Keywords
Humans (19); Animals (10); HTLV-1 (7); Protein Binding (7); Mice (6);
Main Referenced Unit & Research Centers
Giga-Signal Transduction - ULiège [BE] (6)
Giga-Cancer - ULiège [BE] (3)
GIGA-CME - GIGA Cancer-Cellular and Molecular Epigenetics - ULiège [BE] (1)
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège [BE] (1)
Giga-Signal Transduction. GIGA-Research (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (64)
Biotechnology (12)
Oncology (11)
Pharmacy, pharmacology & toxicology (7)
Microbiology (7)

Publications (total 105)

The most downloaded
608 downloads
Florins, A.-F., Gillet, N., Asquith, B., Boxus, M., Burteaux, C., Twizere, J.-C., Urbain, P., Vandermeers, F., Debacq, C., Sanchez-alcaraz, M. T., Schwartz-Cornil, I., Kerkhofs, P., Jean, G., Thewis, A., Hay, J., Mortreux, F., Wattel, E., Reichert, M., Burny, A., ... Willems, L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Frontiers in Bioscience: A Journal and Virtual Library, 12, 1520-1531. doi:10.2741/2165 https://hdl.handle.net/2268/20537

The most cited

1070 citations (OpenCitations)

Rolland, T.* , Tasan, M.* , Charloteaux, B.* , Pevzner, S. J.* , Zhong, Q.* , Sahni, N.* , Yi, S.* , Lemmens, I., Fontanillo, C., Mosca, R., Kamburov, A., Ghiassian, S. D., Yang, X., Ghamsari, L., Balcha, D., Begg, B. E., Braun, P., Brehme, M., Broly, M. P., ... Vidal, M. (2014). A proteome-scale map of the human interactome network. Cell, 159 (5), 1212-26. doi:10.1016/j.cell.2014.10.050 https://hdl.handle.net/2268/190434

Colinet, M.* , Chiver, I.* , Bonafina, A., Masset, G., Almansa Amores, D., Di Valentin, E., Twizere, J.-C., Nguyen, L.* , & Espuny Camacho, I. M.*. (2024). SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids. BioRXiv.
* These authors have contributed equally to this work.

Lambourne, L., Mattioli, K., Santoso, C., Sheynkman, G., Inukai, S., Kaundal, B., Berenson, A., Spirohn-Fitzgerald, K., Bhattacharjee, A., Rothman, E., Shrestha, S., Laval, F., Yang, Z., Bisht, D., Sewell, J. A., Li, G., Prasad, A., Phanor, S., Lane, R., ... Fuxman Bass, J. I. (2024). Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms. bioRxiv : the preprint server for biology. doi:10.1101/2024.03.12.584681

Nelson, D. R., Mystikou, A., Jaiswal, A., Rad-Menendez, C., Preston, M. J., De Boever, F., El Assal, D. C., Daakour, S., Lomas, M. W., Twizere, J.-C., Green, D. H., Ratcliff, W. C., & Salehi-Ashtiani, K. (2024). Macroalgal deep genomics illuminate multiple paths to aquatic, photosynthetic multicellularity. Molecular Plant. doi:10.1016/j.molp.2024.03.011
Peer Reviewed verified by ORBi

Abboud, D., Abboud, C., Inoue, A., Twizere, J.-C., & Hanson, J. (February 2024). Basal interaction of the orphan receptor GPR101 with arrestins leads to constitutive internalization. Biochemical Pharmacology, 220, 116013. doi:10.1016/j.bcp.2023.116013
Peer Reviewed verified by ORBi

Maseko, S. B., Brammerloo, Y., Van Molle, I., Sogues, A., Martin, C., Gorgulla, C., Plant, E., Olivet, J., Blavier, J., Ntombela, T., Delvigne, F., Arthanari, H., El Hajj, H., Bazarbachi, A., Van Lint, C., Salehi-Ashtiani, K., Remaut, H., Ballet, S., Volkov, A. N., & Twizere, J.-C. (21 July 2023). Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction. Antiviral Research, 217, 105675. doi:10.1016/j.antiviral.2023.105675
Peer Reviewed verified by ORBi

Laval, F., Coppin, G., Twizere, J.-C., & Vidal, M. (24 May 2023). Homo cerevisiae-Leveraging Yeast for Investigating Protein-Protein Interactions and Their Role in Human Disease. International Journal of Molecular Sciences, 24 (11), 9179. doi:10.3390/ijms24119179
Peer Reviewed verified by ORBi

Wang, X.-W., Madeddu, L., Spirohn, K., Martini, L., Fazzone, A., Becchetti, L., Wytock, T., Kovács, I., Balogh, O., Benczik, B., Pétervári, M., Ágg, B., Ferdinandy, P., Vulliard, L., Menche, J., Colonnese, S., Petti, M., Scarano, G., Cuomo, F., ... Liu, Y.-Y. (22 March 2023). Assessment of community efforts to advance network-based prediction of protein-protein interactions. Nature Communications, 14 (1), 1582. doi:10.1038/s41467-023-37079-7
Peer Reviewed verified by ORBi

Bruyere, D., RONCARATI, P., Lebeau, A., Lerho, T., Poulain, F., Hendrick, E., Pilard, C., Reynders, C., Ancion, M., Luyckx, M., Renard, M., Jacob, Y., Twizere, J.-C., Peiffer, R., Peulen, O., Delvenne, P., Hubert, P., McBride, A., Gillet, N., ... Herfs, M. (2023). Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair. Theranostics, 13 (3), 1130 - 1149. doi:10.7150/thno.78091
Peer Reviewed verified by ORBi

Beauvois, A.* , Gazon, H.* , Chauhan, P. S., Jamakhani, M., Jacques, J.-R., Thiry, M., Dejardin, E., Di Valentin, E., Twizere, J.-C., Péloponèse, J.-M., Njock, M.-S., Yasunaga, J.-I., Matsuoka, M., Hamaïdia, M.* , & Willems, L.*. (2023). The helicase-like transcription factor redirects the autophagic flux and restricts human T-cell leukemia virus type 1 infection. Proceedings of the National Academy of Sciences of the United States of America, 120 (31), 2216127120. doi:10.1073/pnas.2216127120
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Al-Khairy, D., Fu, W., Alzahmi, A. S., Twizere, J.-C., Amin, S. A., Salehi-Ashtiani, K., & Mystikou, A. (23 November 2022). Closing the Gap between Bio-Based and Petroleum-Based Plastic through Bioengineering. Microorganisms, 10 (12), 2320. doi:10.3390/microorganisms10122320
Peer Reviewed verified by ORBi

Kim, D.-K., Weller, B., Lin, C.-W., Sheykhkarimli, D., Knapp, J. J., Dugied, G., Zanzoni, A., Pons, C., Tofaute, M. J., Maseko, S. B., Spirohn, K., Laval, F., Lambourne, L., Kishore, N., Rayhan, A., Sauer, M., Young, V., Halder, H., la Rosa, N. M.-D., ... Falter-Braun, P. (10 October 2022). A proteome-scale map of the SARS-CoV-2–human contactome. Nature Biotechnology, 41 (1), 140-149. doi:10.1038/s41587-022-01475-z
Peer Reviewed verified by ORBi

Bouhtit, F., Najar, M., Rahmani, S., Melki, R., Najimi, M., Sadki, K., Boukhatem, N., Twizere, J.-C., Meuleman, N., Lewalle, P., Lagneaux, L., & Merimi, M. (August 2022). Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases. Inflammation Research, 71 (7-8), 887-898. doi:10.1007/s00011-022-01573-3
Peer Reviewed verified by ORBi

Olivet, J., Maseko, S. B., Volkov, A. N., Salehi-Ashtiani, K., Das, K., Calderwood, M. A., Twizere, J.-C.* , & Gorgulla, C.*. (2022). A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals. Molecular Therapy. doi:10.1016/j.ymthe.2022.02.015
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Lebeau, A.* , Bruyère, D.* , RONCARATI, P., Peixoto, P., Hervouet, E., COBRAIVILLE, G., Taminiau, B., Masson, M., Gallego, C., Mazzucchelli, G., Smargiasso, N., Fleron, M., Baiwir, D., Hendrick, E., Pilard, C., Lerho, T., Reynders, C., Ancion, M., GREIMERS, R., ... Herfs, M. (28 February 2022). HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources. Nature Communications, 13 (1), 1076. doi:10.1038/s41467-022-28724-8
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Vandermeulen, C., O'Grady, T., Wayet, J., Galvan, B., Maseko, S. B., Cherkaoui, M., Desbuleux, A., Coppin, G., Olivet, J., Ben Ameur, L., Kataoka, K., Ogawa, S., Hermine, O., Marcais, A., Thiry, M., Mortreux, F., Calderwood, M. A., Van Weyenbergh, J., Peloponese, J.-M., ... Twizere, J.-C. (2021). The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape. PLoS Pathogens, 17 (9), 1009919. doi:10.1371/journal.ppat.1009919
Peer Reviewed verified by ORBi

Kerselidou, D., Dohai, B. S., Nelson, D. R., Daakour, S., De Cock, N., Hassoun, Z. E. O., Kim, D.-K., Olivet, J., El Assal, D. C., Jaiswal, A., Alzahmi, A., Saha, D., Pain, C., Matthijssens, F., Lemaitre, P., Herfs, M., Chapuis, J., Ghesquiere, B., Vertommen, D., ... Twizere, J.-C. (2021). Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Science Advances, 7 (19). doi:10.1126/sciadv.abe8349
Peer Reviewed verified by ORBi

Lim, H. J., Yoon, H., Kim, H., Kang, Y.-W., Kim, J.-E., Kim, O. Y., Lee, E.-Y., Twizere, J.-C., Rak, J., & Kim, D.-K. (2021). Extracellular Vesicle Proteomes Shed Light on the Evolutionary, Interactive, and Functional Divergence of Their Biogenesis Mechanisms. Frontiers in Cell and Developmental Biology, 9, 734950. doi:10.3389/fcell.2021.734950
Peer Reviewed verified by ORBi

Caillet-Saguy, C., Durbesson, F., Rezelj, V. V., Gogl, G., Tran, Q. D., Twizere, J.-C., Vignuzzi, M., Vincentelli, R., & Wolff, N. (2021). Host PDZ-containing proteins targeted by SARS-CoV-2. FEBS Journal. doi:10.1111/febs.15881
Peer Reviewed verified by ORBi

dos Santos, D. F., Bairros de Pilger, D. R., Vandermeulen, C., Khouri, R., Pedersoli Mantoani, S., Gonçalves Nunes, P. S., de Andrade, P., Carvalho, I., Casseb, J., Twizere, J.-C., Willems, L., Freitas-Junior, L., & Kashima, S. (08 September 2020). Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells. Bioorganic and Medicinal Chemistry, 28, 115746. doi:10.1016/j.bmc.2020.115746
Peer Reviewed verified by ORBi

Luck, K., Kim, D.-K., Lambourne, L., Spirohn, K., Begg, B. E., Bian, W., Brignall, R., Cafarelli, T., Campos-Laborie, F. J., CHARLOTEAUX, B., Choi, D., Coté, A. G., Daley, M., Deimling, S., Desbuleux, A., Dricot, A., Gebbia, M., Hardy, M. F., Kishore, N., ... Calderwood, M. A. (2020). A reference map of the human binary protein interactome. Nature, 580 (7803), 402-408. doi:10.1038/s41586-020-2188-x
Peer Reviewed verified by ORBi

Verrillo, G., Hanache, S., Duchemin, A., Herfs, M., DELVENNE, P., Tassin, A.-M., Vernos, I., Orange, F., Martin, M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (February 2019). Unveiling of a new role for DPF3 protein in cancer biology [Poster presentation]. Belgian Association for Cancer Research (BACR) meeting 2019.

Veloso, A., Martin, M., Bruyr, J., O'Grady, T., Deroanne, C., Mottet, D., Twizere, J.-C., Cherrier, T.* , & Dequiedt, F.*. (2019). Dephosphorylation of HDAC4 by PP2A-Bdelta unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Cell death & disease, 10 (7), 512. doi:10.1038/s41419-019-1743-6
Peer reviewed
* These authors have contributed equally to this work.

Choi, S. G., Olivet, J., Cassonnet, P., Vidalain, P.-O., Luck, K., Lambourne, L., Spirohn, K., Lemmens, I., Dos Santos, M., Demeret, C., Jones, L., Rangarajan, S., Bian, W., Coutant, E. P., Janin, Y. L., van der Werf, S., Trepte, P., Wanker, E. E., De Las Rivas, J., ... Jacob, Y. (2019). Maximizing binary interactome mapping with a minimal number of assays. Nature Communications, 10 (1), 3907. doi:10.1038/s41467-019-11809-2
Peer Reviewed verified by ORBi

Lebrun, M., Lambert, J., Riva, L., Thelen, N., Rambout, X., Blondeau, C., Thiry, M., Snoeck, R., Twizere, J.-C., Dequiedt, F., Andrei, G., & Sadzot-Delvaux, C. (17 July 2018). Varicella Zoster Virus ORF9p binding to cellular adaptor protein complex-1 is important for viral infectivity. Journal of Virology, 92 (15). doi:10.1128/JVI.00295-18
Peer Reviewed verified by ORBi

Bruyère, D., Lebeau, A., RONCARATI, P., Hendrick, E., Masson, M., Twizere, J.-C., Pilard, C., Hubert, P., DELVENNE, P., & Herfs, M. (30 May 2018). Deciphering the radiosensitivity of HPV-positive tumors [Poster presentation]. 5th meeting on emerging issues in oncogenic virus research, San Pietro in Bevagna, Italy.

Bruyère, D., Lebeau, A., RONCARATI, P., Hendrick, E., Masson, M., Twizere, J.-C., Pilard, C., Hubert, P., DELVENNE, P., & Herfs, M. (28 May 2018). Deciphering the radiosensitivity of HPV-positive tumors [Poster presentation]. EDT-Immunology day 2018, Liège, Belgium.

Verrillo, G., Hanache, S., Duchemin, A., Herfs, M., DELVENNE, P., Tassin, A.-M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (01 February 2018). Unveiling a New Role of DPF3 Protein in Cancer Biology [Poster presentation]. Télévie's Researchers Seminar 2018.

Gusareva, E. S., Twizere, J.-C., Sleegers, K., Dourlen, P., Abisambra, J. F., Meier, S., Cloyd, R., Weiss, B., Dermaut, B., Bessonov, K., van der Lee, S. J., Carrasquillo, M. M., Katsumata, Y., Cherkaoui, M., Asselbergh, B., Ikram, M. A., Mayeux, R., Farrer, L. A., Haines, J. L., ... Van Steen, K. (2018). Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiology of Aging, 72, 188.e3-188.e12. doi:10.1016/j.neurobiolaging.2018.08.001
Peer Reviewed verified by ORBi

Amininejad, L.* , Charloteaux, B.* , Theatre, E., Liefferinckx, C., Dmitrieva, J., Hayard, P., Muls, V., Maisin, J.-M., Schapira, M., Ghislain, J.-M., Closset, P., Talib, M., Abramowicz, M., Momozawa, Y., Deffontaine, V., Crins, F., Mni, M., Karim, L., Cambisano, N., ... Franchimont, D.*. (2018). Analysis of Genes Associated With Monogenic Primary Immunodeficiency Identifies Rare Variants in XIAP in Patients With Crohn's Disease. Gastroenterology, 154 (8), 2165-2177. doi:10.1053/j.gastro.2018.02.028
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Dupuis, N., Laschet, C., Franssen, D., Martyna, S., Gilissen, J., Geubelle, P., Soni, A., Parent, A.-S., Pirotte, B., Chevigné, A., Twizere, J.-C., & Hanson, J. (01 June 2017). Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Molecular Pharmacology, 91 (6), 595-608. doi:10.1124/mol.116.107714
Peer Reviewed verified by ORBi

Verrillo, G., Hanache, S., Duchemin, A., Herfs, M., DELVENNE, P., Tassin, A.-M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (11 May 2017). Unveiling a New Role of DPF3 Protein in Cancer Biology [Poster presentation]. PhD Day.

Vandermeulen, C., Cherkaoui, M., Calderwood, M. A., Hill, D. E., Charloteaux, B., Vidal, M., Dequiedt, F., & Twizere, J.-C. (08 March 2017). Unravelling Potential Roles of HTLV-1 Tax and HBZ Proteins in mRNA Splicing Regulation [Poster presentation]. 18th International Conference on Human Retrovirology: HTLV, Tokyo, Japan.

Verrillo, G., Duchemin, A., Hanache, S., Herfs, M., DELVENNE, P., Tassin, A.-M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (01 February 2017). Unveiling a New Role of DPF3 Protein in Cancer Biology [Poster presentation]. Giga Day.

Jamet, A., Dervyn, R., Lapaque, N., Bugli, F., Perez-Cortez, N. G., Blottière, H. M., Twizere, J.-C., Sanguinetti, M., Posteraro, B., Serror, P., & Maguin, E. (2017). The Enterococcus faecalis virulence factor ElrA interacts with the human Four-And-A-Half LIM Domains Protein. Scientific Reports, 7 (1). doi:10.1038/s41598-017-04875-3
Peer Reviewed verified by ORBi

Dupuis, N., Franssen, D., Laschet, C., Geubelle, P., Soni, A., Abboud, D., Twizere, J.-C., Pirotte, B., & Hanson, J. (26 September 2016). Small molecule ligands for the orphan GPR27 [Poster presentation]. GLISTEN meeting 2016 in Prague.

Vandermeulen, C., Cherkaoui, M., Calderwood, M. A., Hill, D. E., Charloteaux, B., Vidal, M., Dequiedt, F., & Twizere, J.-C. (19 September 2016). Construction of an interactome map of Tax and HBZ HTLV-1 viral proteins with transcriptional and post-transcriptional regulators [Poster presentation]. International Conference on System Biology 2016.

Kerselidou, D., Daakour, S., & Twizere, J.-C. (September 2016). Regulation of the NOTCH pathway by the endoplasmic resident protein EXT-1 [Poster presentation]. The 7th EMBO Meeting.

Lebrun, M., riva, L., lambert, J., Rambout, X., Thiry, M., blondeau, C., Twizere, J.-C., Dequiedt, F., & Sadzot-Delvaux, C. (20 May 2016). Role of Varicella Zoster virus ORF9p in the secondary egress : importance of its interaction with the cellular Adaptin Protein-1 [Poster presentation]. 2015 Colorado Alphaherpesvirus Latency Society Symposium, Vail, United States - Colorado.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Geubelle, P., Laschet, C., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (25 January 2016). Identification of small molecule ligands for the orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2016.

Daakour, S., Hajingabo, L. J., Kerselidou, D., Devresse, A., Kettmann, R., Simonis, N., Dequiedt, F., & Twizere, J.-C. (2016). Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer, 16 (1), 335. doi:10.1186/s12885-016-2374-2
Peer Reviewed verified by ORBi

Rambout, X., Detiffe, C., Bruyr, J., Mariavelle, E., Cherkaoui, M., Brohee, S., Demoitie, P., Lebrun, M., Soin, R., Lesage, B., Guedri, K., Beullens, M., Bollen, M., Farazi, T. A., Kettmann, R., Struman, I., Hill, D. E., Vidal, M., Kruys, V., ... Dequiedt, F. (2016). The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression. Nature Structural and Molecular Biology. doi:10.1038/nsmb.3243
Peer Reviewed verified by ORBi

Kerselidou, D., Daakour, S., & Twizere, J.-C. (October 2015). Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBW7 common interactor [Poster presentation]. The Notch Meeting IX.

Lebrun, M., riva, L., Rambout, X., Thiry, M., Blondeau, C., Twizere, J.-C., Dequiedt, F., & Sadzot-Delvaux, C. (26 July 2015). Identification of VZV ORF9p potential cellular partners that could be important for the viral egress [Poster presentation]. 40th international herpesvirus workshop, boise, United States - Idaho.

Zune, Q., Delepierre, A., Gofflot, S., Bauwens, J., Twizere, J.-C., Punt, P. J., Francis, F., Bawin, T., Toye, D., & Delvigne, F. (2015). A fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae. Applied Microbiology and Biotechnology. doi:10.1007/s00253-015-6608-z
Peer Reviewed verified by ORBi

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (27 January 2015). ßarrestin coupling of the orphan GPCR GPR27 [Poster presentation]. GIGA-day 2015, Liege, Belgium.

Bridoux, L., Bergiers, I., Draime, A., Halbout, M., Deneyer, N., Twizere, J.-C., & Rezsohazy, R. (2015). KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity. Biochimica et Biophysica Acta, 1849 (10), 1298-311. doi:10.1016/j.bbagrm.2015.08.006
Peer Reviewed verified by ORBi

Vandermeulen, C., Hajingabo, L.-J., & Twizere, J.-C. (2015). Comparative Interactome of HIV-1 Tat and Human T Lymphotropic Virus Type-1 Tax and the Cellular Transcriptional Machinery. AIDS Research and Human Retroviruses, 31 (12), 1204-5. doi:10.1089/aid.2014.0377
Peer Reviewed verified by ORBi

Mansour, M. R., Reed, C., Eisenberg, A. R., Tseng, J.-C., Twizere, J.-C., Daakour, S., Yoda, A., Rodig, S. J., Tal, N., Shochat, C., Berezovskaya, A., DeAngelo, D. J., Sallan, S. E., Weinstock, D. M., Izraeli, S., Kung, A. L., Kentsis, A., & Look, A. T. (2015). Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. British Journal of Haematology, 168 (2), 230-8. doi:10.1111/bjh.13115
Peer Reviewed verified by ORBi

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (October 2014). Identifying ligands for orphan receptors: test screening of a SOSA library with a complementation assay for orphan GPCR GPR27 [Poster presentation]. third annual meeting of the GDR3545, Montpellier, France.

Brognaux, A., Francis, F., Twizere, J.-C., Thonart, P., & Delvigne, F. (08 September 2014). Characterization of the scale-down effect on the extracellular proteome of Escherichia coli and correlation with membrane permeability [Poster presentation]. ESBES 2014, Lille, France.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (16 July 2014). Ligand-independent Identification of orphan GPCR Signaling pathways [Paper presentation]. World Congress of basic & clinical Pharmacology, Cape Town, South Africa.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (05 June 2014). LIGAND-INDEPENDENT IDENTIFICATION OF ORPHAN GPCR ARRESTIN BINDING [Poster presentation]. 23èmes Journées franco-belges de Pharmacochimie, Metz, France.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (04 April 2014). Ligand-independent Identification of orphan GPR27 Signaling pathways [Poster presentation]. Physphar 2014.

Brognaux, A., Francis, F., Twizere, J.-C., Thonart, P., & Delvigne, F. (2014). Scale-down effect on the extracellular proteome of Escherichia coli: correlation with membrane permeability and modulation according substrate heterogeneities. Bioprocess and Biosystems Engineering. doi:10.1007/s00449-013-1119-8
Peer Reviewed verified by ORBi

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (14 January 2014). Development of a luciferase complementation assay for ligand screening on orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2014.

Juvenal Hajingabo, L., Daakour, S., Martin, M., Grausenburger, R., Panzer-Grumayer, R., Dequiedt, F., Simonis, N., & Twizere, J.-C. (2014). Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia. Molecular Biology of the Cell. doi:10.1091/mbc.E14-06-1038
Peer Reviewed verified by ORBi

Rolland, T.* , Tasan, M.* , Charloteaux, B.* , Pevzner, S. J.* , Zhong, Q.* , Sahni, N.* , Yi, S.* , Lemmens, I., Fontanillo, C., Mosca, R., Kamburov, A., Ghiassian, S. D., Yang, X., Ghamsari, L., Balcha, D., Begg, B. E., Braun, P., Brehme, M., Broly, M. P., ... Vidal, M. (2014). A proteome-scale map of the human interactome network. Cell, 159 (5), 1212-26. doi:10.1016/j.cell.2014.10.050
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* These authors have contributed equally to this work.

Bergiers, I., Lambert, B., Daakour, S., Twizere, J.-C., & Rezsohazy, R. (2014). Hox protein interactions: screening and network building. Methods in Molecular Biology, 1196, 319-48. doi:10.1007/978-1-4939-1242-1_20
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Shochat, C., Tal, N., Gryshkova, V., Birger, Y., Bandapalli, O. R., Cazzaniga, G., Gershman, N., Kulozik, A. E., Biondi, A., Mansour, M. R., Twizere, J.-C., Muckenthaler, M. U., Ben-Tal, N., Constantinescu, S. N., Bercovich, D., & Izraeli, S. (2014). Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia. Blood, 124 (1), 106-10. doi:10.1182/blood-2013-10-529685
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Blibek, K., Rambout, X., Beaufays, J., Lins, L., Dequiedt, F., & Twizere, J.-C. (2014). An interaction map for HTLV-1 Tax and PDZ-containing proteins. Retrovirology, 11, 101. doi:10.1186/1742-4690-11-S1-P101
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Dupuis, N., Gilissen, J., Twizere, J.-C., Pirotte, B., & Hanson, J. (18 October 2013). Development of an original β-arrestin complementation assay for orphan GPCR GPR27(SREB1) ligand and signaling pathways determination [Poster presentation]. Autumn Meeting of Belgian Society of Physiology and Pharmacology.

Blibek, K., Fujii, N., Legros, S., Boxus, M., Dewulf, J.-F., Zimmermann, P., Kettmann, R., Borg, J.-P., Dequiedt, F., & Twizere, J.-C. (29 June 2013). Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions [Poster presentation]. 16th International Conference on Human Retrovirology : HTLV and Related Viruses, Montréal, Québec., Canada.

Blibek, K., Fujii, N., Legros, S., Boxus, M., Dewulf, J.-F., Zimmermann, P., Kettmann, R., Dequiedt, F., & Twizere, J.-C. (29 June 2013). Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions [Poster presentation]. 16th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV, Montréal, Québec., Canada.

Blibek, K., Rambout, X., beaufays, J., Lins, L., Dequiedt, F., & Twizere, J.-C. (29 June 2013). An interaction map for HTLV-1 Tax and PDZ-containing proteins [Poster presentation]. 16th International Conference on Human Retrovirology : HTLV and Related Viruses, Montréal, Québec., Canada.

Brognaux, A., Francis, F., Twizere, J.-C., Thonart, P., & Delvigne, F. (23 April 2013). Characterization of the extracellular proteome of Escherichia coli according to the scale-up of bioprocesses and correlation with membrane permeability [Poster presentation]. 2nd European Congress of Applied Biotechnology, La Haye, Netherlands.

Damon, C., Boxus, M., Twizere, J.-C., Portetelle, D., & Vandenbol, M. (February 2013). An eYFP Reporter Gene for the Yeast Two-hybrid System. Protein Journal, 32 (2), 126-130. doi:10.1007/s10930-013-9467-4
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Rambout, X., Simonis, N., Brohée, S., Cherkaoui, M., Lebrun, M., Vidal, M., Kruys, V., Twizere, J.-C., Soin, R., & Dequiedt, F. (28 January 2013). Interactomic map of the Ets factors family : Identification of unexpected functions in mRNA processing [Poster presentation]. GIGA Day 2013.

Martin, M., Geudens, I., Bruyr, J., Potente, M., Bleuart, A., Lebrun, M., Simonis, N., Deroanne, C., Twizere, J.-C., Soubeyran, P., Peixoto, P., Mottet, D., Janssens, V., Hofmann, W.-K., Claes, F., Carmeliet, P., Kettmann, R., Gerhardt, H., & Dequiedt, F. (2013). PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. EMBO Journal. doi:10.1038/emboj.2013.187
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Brognaux, A., Neubauer, P., Twizere, J.-C., Francis, F., Gorret, N., Thonart, P., & Delvigne, F. (2013). Direct and indirect use of GFP whole cell biosensors for the assessment of bioprocess performances: design of milliliter scale-down bioreactors. Biotechnology Progress, 29 (1), 48-59. doi:10.1002/btpr.1660
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Bergiers, I., Bridoux, L., Nguyen, N., Twizere, J.-C., & Rezsohazy, R. (2013). The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. PLoS ONE, 8 (11), 80387. doi:10.1371/journal.pone.0080387
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Damon, C., Twizere, J.-C., Dmitrieva, J. B., Muhovski, Y., Francis, F., Lins, L., Ledoux, Q., Luwaert, W., István, E. M., Mauro, S., Ongena, M., Thonart, P., Veys, P., Portetelle, D., & Vandenbol, M. (June 2012). Interaction network of antimicrobial peptides of Arabidopsis thaliana, based on high-throughput yeast two-hybrid screening [Poster presentation]. Third International Symposium on Antimicrobial Peptides, Lille, France.

Brognaux, A., Neubauer, P., Twizere, J.-C., Thonart, P., & Delvigne, F. (18 May 2012). Development of mini scale-down platform based on the response of GFP microbial biosensors [Poster presentation]. Biosensors 2012, Cancun, Mexico.

Brognaux, A., Neubauer, P., Twizere, J.-C., Thonart, P., & Delvigne, F. (15 March 2012). Use of microbial biosensors to detect substrate heterogeneities at the single cell level and assess microbial viability: Validation of a mini-bioreactor platform [Paper presentation]. 2nd BioProScale "Inhomogeneities in large scale bioprocess: system biology and process dynamics".

Rambout, X., Simonis, N., Demoitié, P., Cherkaoui, M., Lebrun, M., Vidal, M., Kruys, V., Twizere, J.-C., & Dequiedt, F. (2012). Interactomic map of the Ets factors family : Identification of unexpected functions in mRNA processing. In Keystone symposium - Protein-RNA Interactions in Biology and Disease (C1).
Peer reviewed

Brognaux, A., Neubauer, P., Twizere, J.-C., Thonart, P., & Delvigne, F. (10 February 2012). Potentiality of using microbial biosensors for the detection of sub-strate heterogeneities and the assessment of microbial viability in industrial bioreactors: a complete set of experiments in chemostat and scale-down reactors, and elaboration of a mini scale-down platform [Paper presentation]. 17th Symposium on Applied and Biological Sciences, Leuven, Belgium.

Boxus, M., Twizere, J.-C., Legros, S., Kettmann, R., & Willems, L. (05 January 2012). Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program. Blood, 119, 151-160. doi:10.1182/blood-2011-05-356790
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Simonis, N., Rual, J.-F., Lemmens, I., Boxus, M., Hirozane-Kishikawa, T., GATOT, J.-S., Dricot, A., Hao, T., Vertommen, D., Legros, S., Daakour, S., Klitgord, N., Martin, M., Willaert, J.-F., Dequiedt, F., Navratil, V., Cusick, M. E., Burny, A., Van Lint, C., ... Twizere, J.-C. (2012). Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology, 9, 26. doi:10.1186/1742-4690-9-26
Peer Reviewed verified by ORBi

Damon, C., Dmitrieva, J. B., Muhovski, Y., Francis, F., Lins, L., Ledoux, Q., Luwaert, W., Marko, I. E., Mauro, S., Ongena, M., Thonart, P., Veys, P., Portetelle, D., Twizere, J.-C., & Vandenbol, M. (2012). Interaction network of antimicrobial peptides of Arabidopsis thaliana, based on hith-throughput yeast two-hybrid screening. Plant Physiology and Biochemistry, 245-252.
Peer Reviewed verified by ORBi

Brognaux, A., Neubauer, P., Twizere, J.-C., Thonart, P., & Delvigne, F. (2012). Potentiality of using microbial biosensors for the detection of substrate heterogeneities and the assessment of microbial viability in industrial bioreactors: a complete set of experiments in chemostat and scale-down reactors, and elaboration of a mini scale-down platform. Communications in Agricultural and Applied Biological Sciences, 77 (1), 3-7.
Peer Reviewed verified by ORBi

Lambert, B., Vandeputte, J., Remacle, S., Bergiers, I., Simonis, N., Twizere, J.-C., Vidal, M., & Rezsohazy, R. (2012). Protein interactions of the transcription factor Hoxa1. BMC Developmental Biology, 12, 29. doi:10.1186/1471-213X-12-29
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Luwaert, W., Vandermoten, S., Ongena, M., Vandenbol, M., Portetelle, D., Thonart, P., Lins, L., Twizere, J.-C., Mauro, S., De Pauw, E., Haubruge, E., & Francis, F. (July 2011). Assessment of aphid saliva role as plant defense elicitation by multiple approaches [Poster presentation]. Hemipteran-Plant Interactions Symposium, Piracicaba, Brazil.

Twizere, J.-C., DEWULF, J.-F., Blibek, K., Legros, S., Boxus, M., Zimmermann, P., FUJII, N., & Kettmann, R. (06 June 2011). Disruption of PDZ protein-protein interactions inhibits Tax transformation and HTLV-1 infection capacities [Poster presentation]. 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses, Leuven, Gembloux, Belgium.

Rambout, X., Simonis, N., Demoitié, P., Vidal, M., Twizere, J.-C., & Dequiedt, F. (29 April 2011). Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes [Poster presentation]. IAP Network 28 : Signal integration mechanisms in health and disease, Bruxelles, Belgium.

Legros, S., Boxus, M., GATOT, J.-S., Van Lint, C., Kruys, V., Kettmann, R., Twizere, J.-C., & Dequiedt, F. (2011). The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6. Oncogene. doi:10.1038/onc.2011.120
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Delvigne, F., Brognaux, A., Francis, F., Twizere, J.-C., Gorret, N., Sorensen, S., & Thonart, P. (2011). Green fluorescent protein (GFP) leakage from microbial biosensors provides useful information for the evaluation of the scale-down effect. Biotechnology Journal, 6, 968-978. doi:10.1002/biot.201000410
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de Barsy, M., Jamet, A., Filopon, D., Nicolas, C., Laloux, G., Rual, J.-F., Muller, A., Twizere, J.-C., Nkengfac, B., Vandenhaute, J., Hill, D. E., Salcedo, S. P., Gorvel, J.-P., Letesson, J.-J., & De Bolle, X. (2011). Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cellular Microbiology, 13 (7), 1044-58. doi:10.1111/j.1462-5822.2011.01601.x
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Twizere, J.-C. (30 June 2010). TARGETS FOR RETROVIRUS ASSOCIATED DISEASES.

Pierard, V., Guiguen, A., Colin, L., Wijmeersch, G., Vanhulle, C., Van Driessche, B., Dekoninck, A., Blaskova, J., Cardona, C., Merimi, M., Vierendeel, V., Calomme, C., Nguyen, T. L.-A., Nuttinck, M., Twizere, J.-C., Kettmann, R., Portetelle, D., Burny, A., Hirsch, I., ... Van Lint, C. (18 June 2010). DNA cytosine methylation in the Bovine Leukemia Virus promoter is associated with latency in a lymphoma-derived B-cell line potential involvement of direct inhibition of cAMP-responsive element (cre)-binding protein/cre modulator/activation transcription factor binding. Journal of Biological Chemistry, 285 (25), 19434-19449. doi:10.1074/jbc.M110.107607
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Rambout, X., Twizere, J.-C., & Dequiedt, F. (2010). Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes. In Inserm Workshop: Interactomics: at the crossroads of biology and bioinformatics.
Peer reviewed

Lecat, A., Di Valentin, E., Fillet, M., Rambout, X., Twizere, J.-C., Dequiedt, F., Piette, J., & Legrand-Poels, S. (28 January 2010). NOD2 interactome [Poster presentation]. inflammation 2010, Luxembourg, Luxembourg.

Legros, S., Boxus, M., Dewulf, J. F., Dequiedt, F., Kettmann, R., & Twizere, J.-C. (2009). Protein-protein interactions and gene expression regulation in HTLV-1 infected cells. Frontiers in Bioscience: A Journal and Virtual Library, 14, 4138-48. doi:10.2741/3518
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Martin, M., Potente, M., Janssens, V., Vertommen, D., Twizere, J.-C., Rider, M., Goris, J., Dimmeler, S., Kettmann, R., & Dequiedt, F. (March 2008). Protein Phosphatase 2a Controls The Activity Of Histone Deacetylase 7 During T Cell Apoptosis And Angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 105 (12), 4727-4732. doi:10.1073/pnas.0708455105
Peer Reviewed verified by ORBi

Samuel, S., Twizere, J.-C., Beifuss, K. K., & Bernstein, L. R. (2008). Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene. Molecular Carcinogenesis, 47 (1), 34-46. doi:10.1002/mc.20358
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Boxus, M., Twizere, J.-C., Legros, S., Dewulf, J.-F., Kettmann, R., & Willems, L. (2008). The HTLV-1 Tax interactome. Retrovirology, 5, 76. doi:10.1186/1742-4690-5-76
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Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Van Lint, C., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., & Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood, 109 (3), 1051-60. doi:10.1182/blood-2006-06-026781
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Florins, A.-F., Gillet, N., Asquith, B., Boxus, M., Burteaux, C., Twizere, J.-C., Urbain, P., Vandermeers, F., Debacq, C., Sanchez-alcaraz, M. T., Schwartz-Cornil, I., Kerkhofs, P., Jean, G., Thewis, A., Hay, J., Mortreux, F., Wattel, E., Reichert, M., Burny, A., ... Willems, L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Frontiers in Bioscience: A Journal and Virtual Library, 12, 1520-1531. doi:10.2741/2165
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Dequiedt, F., Martin, M., Von Blume, J., Vertommen, D., Lecomte, E., Mari, N., Heinen, M.-F., Bachmann, M., Twizere, J.-C., Huang, M. C., Rider, M. H., Piwnica-Worms, H., Seufferlein, T., & Kettmann, R. (2006). New Role For Hpar-1 Kinases Emk And C-Tak1 In Regulating Localization And Activity Of Class Iia Histone Deacetylases. Molecular and Cellular Biology, 26 (19), 7086-7102. doi:10.1128/MCB.00231-06
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Twizere, J.-C., Lefebvre, L., Collete, D., Debacq, C., Urbain, P., Heremans, H., Jauniaux, J.-C., Burny, A., Willems, L., & Kettmann, R. (2005). The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity. Journal of Biological Chemistry, 280 (33), 29804-11. doi:10.1074/jbc.M503674200
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Samuel, S., Twizere, J.-C., & Bernstein, L. R. (2005). YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence. Biochemical Journal, 388 (Pt 3), 921-8. doi:10.1042/BJ20041497
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Twizere, J.-C., Kruys, V., Lefebvre, L., Vanderplasschen, A., Collete, D., Debacq, C., Lai, W. S., Jauniaux, J.-C., Bernstein, L. R., Semmes, O. J., Burny, A., Blackshear, P. J., Kettmann, R., & Willems, L. (2003). Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. Journal of the National Cancer Institute, 95 (24), 1846-59. doi:10.1093/jnci/djg118
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Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Willems, L., & Kettmann, R. (26 May 2000). Discordance between Bovine Leukemia Virus Tax immortalization in vitro and oncogenicity in vivo: generation of a rare CD8-positive B-lymphocyte leukemia by the TAX phosphorylation mutant [Poster presentation]. 175° Réunion de la Société Belge de Biochimie et de Biologie moléculaire, Leuven, Belgium.

Willems, L., Burny, A., Collete, D., Dangoisse, O., Dequiedt, F., GATOT, J.-S., Kerkhofs, P., Lefebvre, L., Merezak, C., Peremans, T., Portetelle, D., Twizere, J.-C., & Kettmann, R. (2000). Genetic Determinants Of Bovine Leukemia Virus Pathogenesis. AIDS Research and Human Retroviruses, 16 (16), 1787-95. doi:10.1089/08892220050193326
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Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Kettmann, R., & Willems, L. (2000). Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo. Journal of Virology, 74 (21), 9895-902. doi:10.1128/JVI.74.21.9895-9902.2000
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Willems, L., Burny, A., Dangoisse, O., Collete, D., Dequiedt, F., GATOT, J.-S., Kerkhofs, P., Lefebvre, L., Merezak, C., Portetelle, D., Twizere, J.-C., & Kettmann, R. (1999). Bovine leukemia virus as a model for human T-cell leukemia virus. Current Topics in Virology.
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Willems, L., Grimonpont, C., Kerkhofs, P., Capiau, C., Gheysen, D., Conrath, K., Roussef, R., Mamoun, R., Portetelle, D., Burny, A., Adam, E., Lefebvre, L., Twizere, J.-C., Heremans, H., & Kettmann, R. (1998). Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation. Oncogene, 16 (17), 2165-76. doi:10.1038/sj.onc.1201765
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