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Lebrun Marielle

Département des sciences de la vie > Virologie - Immunologie

Département des sciences de la vie

GIGA I3 - Virology and Immunology

See author's contact details
ORCID
0000-0001-7430-6529
Main Referenced Co-authors
Sadzot, Catherine  (32)
Thiry, Marc  (13)
Sanchez Gil, Judith  (10)
Rogister, Bernard  (9)
Dequiedt, Franck  (8)
Main Referenced Keywords
ORF9p (4); Varicella zoster virus (4); VZV (4); Assembly (2); axonal infection (2);
Main Referenced Unit & Research Centers
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège [BE] (9)
Giga-Signal Transduction - ULiège [BE] (2)
Giga-Cancer - ULiège [BE] (1)
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE] (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (26)
Microbiology (15)
Oncology (3)
Immunology & infectious disease (2)
Anatomy (cytology, histology, embryology...) & physiology (2)

Publications (total 44)

The most downloaded
1947 downloads
Thiry, M., Bourmeyster, N., Dommes, J., Lebrun, M., Rigo, P., & Jaspar-Versali, M.-F. (2016). Biologie moléculaire: exercices et méthodes. Paris, France: Dunod. https://hdl.handle.net/2268/200952

The most cited

478 citations (Scopus®)

Niemi, M., Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., ... HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x https://hdl.handle.net/2268/260539

Van Breedam, E., Buyle-Huybrecht, T., Govaerts, J., Meysman, P., Bours, A., Boeren, M., Di Stefano, J., Caers, T., De Reu, H., Dirkx, L., Schippers, J., Bartholomeus, E., Lebrun, M., Sadzot, C., Rybakowska, P., Alarcón-Riquelme, M. E., Marañón, C., Laukens, K., Delputte, P., ... Ponsaerts, P. (2023). Lack of strong innate immune reactivity renders macrophages alone unable to control productive Varicella-Zoster Virus infection in an isogenic human iPSC-derived neuronal co-culture model. Frontiers in Immunology, 14, 1177245. doi:10.3389/fimmu.2023.1177245
Peer Reviewed verified by ORBi

Boeren, M., Van Breedam, E., Buyle-Huybrecht, T., Lebrun, M., Meysman, P., Sadzot, C., Van Tendeloo, V. F., Mortier, G., Laukens, K., Ogunjimi, B., Ponsaerts, P., & Delputte, P. (14 November 2022). Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α. Viruses, 14 (11), 2517. doi:10.3390/v14112517
Peer Reviewed verified by ORBi

Sanchez Gil, J., Dubois, M., Neirinckx, V., LOMBARD, A., Coppieters't Wallant, N., D'arrigo, P., Isci, D., Aldenhoff, T., Brouwers, B., Lassence, C., ROGISTER, B., Lebrun, M., & Sadzot, C. (2022). Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4+ GBM cells: a proof-of-principle. Molecular Therapy: Oncolytics. doi:10.1016/j.omto.2022.06.002
Peer Reviewed verified by ORBi

D'arrigo, P., Sanchez Gil, J., Dubois, M., Lebrun, M., ROGISTER, B., & Sadzot, C. (02 August 2021). An armed oncolytic herpesvirus to counteract gioblastoma stem-like cells functions [Poster presentation]. International Herpesvirus Workshop.
Peer reviewed

Lebrun, M., Lambert, J., Zhou, M., Jassin, M., Oliver, S., Arvin, A., & Sadzot, C. (August 2021). The role of ORF9p in VZV-induced cell-cell fusion [Paper presentation]. 45th annual International Herpesvirus Workshop.

Buyle-Huybrechts, T., Boeren, M., Van Breedam, E., Perik, M., Lebrun, M., Sadzot, C., Rybakowska, P., Maranon Lizana, C., Loeys, B., Laukens, K., Delputte, P., Ponsaerts, P., & Ongunjimi, B. (August 2021). Suppression of Varicella Zoster Virus Spread by Macrophages in a hiPSC-derived Neuro-Immune Cell Culture Model [Paper presentation]. IHW2021: 45th International Herpesvirus Workshop.

Boeren, M., Buyle-Huybrecht, T., Van Breedam, E., Nijak, A., Alaerts, M., Lebrun, M., Sadzot, C., Van Tendeloo, V., Loeys, B., Mortier, G., Laukens, K., Ogunjimi, B., Ponsaerts, P., & Delputte, P. (August 2021). Interferon-α limits varicella-zoster virus (VZV) spread in human iPSC-derived neuronal cultures upon axonal infection [Paper presentation]. IHW2021: 45th International Herpesvirus Workshop.

D'arrigo, P., Sanchez Gil, J., Lebrun, M., Rogister, B., & Sadzot, C. (01 April 2021). An oncolytic herpesvirus to counteract Glioblastoma Stem Cells function [Paper presentation]. Journée des chercheurs Télévie, Belgium.

Niemi, M., Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., ... HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x
Peer Reviewed verified by ORBi

Sanchez Gil, J., D'arrigo, P., Neirinckx, V., Isci, D., Brouwers, B., LOMBARD, A., Rogister, B., Lebrun, M., & Sadzot, C. (2021). Targeting of CXCR4+ Glioblastoma initiating cells with a retargeted Oncolytic Herpesvirus (oHSV): proof of concept [Paper presentation]. IHW2021: 45th International Herpesvirus Workshop.

Sanchez Gil, J., D'arrigo, P., Lebrun, M., Isci, D., Coppieters, N., Rogister, B., Chevigné, A., & Sadzot, C. (2021). Targeting of CXCR4+ Glioblastoma initiating cells with a retargeted oncolytic herpesvirus [Poster presentation]. Journée des chercheurs Télévie.

D'arrigo, P., Sanchez Gil, J., Lebrun, M., ROGISTER, B., & Sadzot, C. (18 December 2020). An oncolytic herpesvirus to counteract Glioblastoma Stem Cells function [Poster presentation]. BELVIR.

Sanchez Gil, J., Lebrun, M., Rogister, B., Chevigné, A., & Sadzot, C. (2020). Targeting of CXCR4+ Glioblastoma initiating cells with a retargeted oncolytic herpesvirus [Poster presentation]. BELVIR.

Sanchez Gil, J., Lebrun, M., Rogister, B., Chevigné, A., & Sadzot, C. (2020). Targeting of CXCR4+ Glioblastoma initiating cells with a retargeted oncolytic herpesvirus [Poster presentation]. Journée des chercheurs Télévie, Bruxelles, Belgium.

Lambert, J., Sadzot, C., Lebrun, M., & Thiry, M. (Other coll.). (19 December 2019). Varicella Zoster Virus ORF9p: hijacker of the autophagy pathway? [Paper presentation]. Belvir 2019, Brussels, Belgium.

Sanchez Gil, J., Lebrun, M., Allegro, A., Chevigné, A., ROGISTER, B., & Sadzot, C. (2019). Targeting of CXCR4+ Glioblastoma initiating cells with a retargeted oncolytic herpesvirus [Poster presentation]. 12th International Oncolytic Virus conference, Rochester, United States - Minnesota.

Lebrun, M., Lambert, J., Riva, L., Thelen, N., Rambout, X., Blondeau, C., Thiry, M., Snoeck, R., Twizere, J.-C., Dequiedt, F., Andrei, G., & Sadzot-Delvaux, C. (17 July 2018). Varicella Zoster Virus ORF9p binding to cellular adaptor protein complex-1 is important for viral infectivity. Journal of Virology, 92 (15). doi:10.1128/JVI.00295-18
Peer Reviewed verified by ORBi

Lebrun, M., Blondeau, C., Riva, L., Lambert, J., Thiry, M., & Sadzot-Delvaux, C. (02 August 2017). The role of the tegument protein ORF9p and its phosphorylation status in VZV nuclear egress [Poster presentation]. 42nd International Herpesvirus Workshop.

Lebrun, M., blondeau, C., Riva, L., Lambert, J., Thiry, M., & Sadzot, B. (29 July 2017). The role of the tegument protein ORF9p and its phosphorylation status in VZV nuclear egress [Paper presentation]. 42nd International Herpesvirus Workshop.

Lambert, J., Lebrun, M., Riva, L., Sanchez Gil, J., Sadzot-Delvaux, C., Andrei, G. (Other coll.), & Snoeck, R. (Other coll.). (29 July 2017). Study of the role of the complex formed by the Varicella Zoster virus ORF9p and the cellular Adaptin Protein-1 in the secondary egress [Poster presentation]. IHW 2017, Ghent, Belgium.

Lambert, J., Lebrun, M., Sanchez-Gil, J., Riva, L., & Sadzot, C. (11 May 2017). CHARACTERIZATION OF THE COMPLEX FORMED BY THE VARICELLA ZOSTER VIRUS ORF9P AND THE CELLULAR ADAPTIN PROTEIN-1 AND ITS ROLE IN THE SECONDARY EGRESS [Poster presentation]. Interuniversity PhD Student Day, Liège, Belgium.

Thiry, M., Bourmeyster, N., Dommes, J., Lebrun, M., Rigo, P., & Jaspar-Versali, M.-F. (2016). Biologie moléculaire: exercices et méthodes. Paris, France: Dunod.

Lebrun, M., riva, L., lambert, J., Rambout, X., Thiry, M., blondeau, C., Twizere, J.-C., Dequiedt, F., & Sadzot-Delvaux, C. (20 May 2016). Role of Varicella Zoster virus ORF9p in the secondary egress : importance of its interaction with the cellular Adaptin Protein-1 [Poster presentation]. 2015 Colorado Alphaherpesvirus Latency Society Symposium, Vail, United States - Colorado.

Rambout, X., Detiffe, C., Bruyr, J., Mariavelle, E., Cherkaoui, M., Brohee, S., Demoitie, P., Lebrun, M., Soin, R., Lesage, B., Guedri, K., Beullens, M., Bollen, M., Farazi, T. A., Kettmann, R., Struman, I., Hill, D. E., Vidal, M., Kruys, V., ... Dequiedt, F. (2016). The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression. Nature Structural and Molecular Biology. doi:10.1038/nsmb.3243
Peer Reviewed verified by ORBi

Lebrun, M., riva, L., Rambout, X., Thiry, M., Blondeau, C., Twizere, J.-C., Dequiedt, F., & Sadzot-Delvaux, C. (26 July 2015). Identification of VZV ORF9p potential cellular partners that could be important for the viral egress [Poster presentation]. 40th international herpesvirus workshop, boise, United States - Idaho.

Lebrun, M., Thiry, M., & Sadzot-Delvaux, C. (15 May 2015). Varicella-Zoster Virus (VZV) assemblons interplay with PML bodies [Poster presentation]. 2015 alphaherpesvirus latency symposium, vail, United States - Colorado.

Lebrun, M. (24 March 2015). Varicella-Zoster Virus (VZV) capsids trapped in PML-bodies: antiviral defense or stress response? [Paper presentation]. séminaire FARAH.

Blondeau, C., Istaz, B., Lebrun, M., thiry, M., Colson, C., & Sadzot-Delvaux, C. (2015). Role of Kinases in VZV Nuclear Egress [Poster presentation]. 40th Annual International Herpesvirus Workshop, boise, United States.

Lebrun, M. (2014). Nuclear capsid aggregates of Varicella-Zoster virus: assembly sites or dead-end depot? [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/168326

Lebrun, M., Thelen, N., Thiry, M., Riva, L., Ote, I., Condé, C., Vandevenne, P., Di Valentin, E., BONTEMS, S., & Sadzot-Delvaux, C. (2014). Varicella-zoster virus induces the formation of dynamic nuclear capsid aggregates. Virology, 454-455, 311-27. doi:10.1016/j.virol.2014.02.023
Peer Reviewed verified by ORBi

Riva, L., Thiry, M., Lebrun, M., L'Homme, L., Piette, J., & Sadzot-Delvaux, C. (2014). Deletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids. Journal of Virology. doi:10.1128/JVI.03215-14
Peer Reviewed verified by ORBi

Rambout, X., Simonis, N., Brohée, S., Cherkaoui, M., Lebrun, M., Vidal, M., Kruys, V., Twizere, J.-C., Soin, R., & Dequiedt, F. (28 January 2013). Interactomic map of the Ets factors family : Identification of unexpected functions in mRNA processing [Poster presentation]. GIGA Day 2013.

Riva, L., Thiry, M., BONTEMS, S., Joris, A., Piette, J., Lebrun, M., & Sadzot-Delvaux, C. (28 January 2013). ORF9p phosphorylation by ORF47p is crucial for the formation and egress of Varicella-­‐ Zoster Virus viral particles [Poster presentation]. GIGA-Day, Liège, Belgium.

Martin, M., Geudens, I., Bruyr, J., Potente, M., Bleuart, A., Lebrun, M., Simonis, N., Deroanne, C., Twizere, J.-C., Soubeyran, P., Peixoto, P., Mottet, D., Janssens, V., Hofmann, W.-K., Claes, F., Carmeliet, P., Kettmann, R., Gerhardt, H., & Dequiedt, F. (2013). PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. EMBO Journal. doi:10.1038/emboj.2013.187
Peer Reviewed verified by ORBi

Riva, L., Thiry, M., BONTEMS, S., Joris, A., Piette, J., Lebrun, M.* , & Sadzot-Delvaux, C.*. (2013). ORF9p phosphorylation by ORF47p is crucial for the formation and egress of the Varicella-zoster virus (VZV) viral particles. Journal of Virology, 87 (5), 2868-2881. doi:10.1128/JVI.02757-12
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Rambout, X., Simonis, N., Demoitié, P., Cherkaoui, M., Lebrun, M., Vidal, M., Kruys, V., Twizere, J.-C., & Dequiedt, F. (2012). Interactomic map of the Ets factors family : Identification of unexpected functions in mRNA processing. In Keystone symposium - Protein-RNA Interactions in Biology and Disease (C1).
Peer reviewed

Lebrun, M., Riva, L., Ote, I., Vandevenne, P., Di Valentin, E., Thiry, M., BONTEMS, S., & Sadzot-Delvaux, C. (2012). Varicella-Zoster virus (VZV) capsids trapped in PML-bodies: antiviral defense or stress response? [Poster presentation]. GIGA-DAY.

Condé, C., Rambout, X., Lebrun, M., Lecat, A., Di Valentin, E., Dequiedt, F., Piette, J., Gloire, G., & Legrand, S. (2012). The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2. PLoS ONE. doi:10.1371/journal.pone.0041005
Peer Reviewed verified by ORBi

Lebrun, M., Ote, I., Riva, L., Vandevenne, P., Condé, C., Piette, J., BONTEMS, S., & Sadzot-Delvaux, C. (July 2011). Characterization of the Varicella-Zoster Virus Tegument proteins encoded by ORF7, 21, 22 and 38 [Poster presentation]. 36th Annual International Herpesvirus Workshop / Varicella Zoster Virus satellite meeting, Gdansk, Poland.

Riva, L., Lebrun, M., BONTEMS, S., Di Valentin, E., Piette, J., & Sadzot-Delvaux, C. (July 2011). Determination of the biological function of the Varicella Zoster Virus ORF9p [Poster presentation]. 36th Annual International Herpesvirus Workshop / Varicella Zoster Virus satellite meeting, Gdansk, Poland.

Vandevenne, P., Lebrun, M., El Mjiyad, N., Ote, I., Di Valentin, E., Habraken, Y., Dortu, E., Piette, J., & Sadzot-Delvaux, C. (February 2011). The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3. PLoS ONE, 9 (2). doi:10.1371/journal.pone.0016870
Peer Reviewed verified by ORBi

Ote, I., Vandevenne, P., Bontems, S., Medina-Palazon, C., Manet, E., Piette, J., Lebrun, M., & Sadzot-Delvaux, C. (18 November 2009). Varicella-Zoster Virus IE4 Protein Interacts with SR Proteins and Exports mRNAs through the TAP/NXF1 Pathway. PLoS ONE, 4 (11), 7882. doi:10.1371/journal.pone.0007882
Peer Reviewed verified by ORBi

Liao, S., Bentley, K., Lebrun, M., Lesslauer, W., Ruddle, F. H., & Ruddle, N. H. (2007). Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules. Proceedings of the National Academy of Sciences of the United States of America, 104 (11), 4577-82. doi:10.1073/pnas.0700334104
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Juan, A. H., Lei, H. Y., Bhargava, P., Lebrun, M., & Ruddle, F. H. (2006). Multiple roles of Hoxc8 in skeletal development. Annals of the New York Academy of Sciences, 1068, 87-94. doi:10.1196/annals.1346.046
Peer Reviewed verified by ORBi

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