G Protein-Coupled Receptor; GPR22; Gi pathway; Screening
Abstract :
[en] GPCRs are the largest family of membrane receptors and are characterized by 7 transmembrane domains. GPR22 is a GPCR that has no known endogenous ligand and is thus considered "orphan". Its presence situated at the heart and brain levels makes it a potential target for new therapeutic pathways.
This study consist in the identification of a synthetic ligand of GPR22 receptor to use it as a pharmacological tool in the study of the signaling channels of GPR22 in order to understand its role and to validate it as a new therapeutic target. The initial hypothesis was that GPR22 is coupled to the Gαi protein.
Research Center/Unit :
Molecular Pharmacology - Medicinal Chemistry
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Geubelle, Pierre ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Gilissen, Julie ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Dupuis, Nadine ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Derj, Anouar ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Laschet, Céline ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Soni, Arvind ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Pirotte, Bernard ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Hanson, Julien ; Université de Liège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22
Alternative titles :
[fr] Identidication, conception et évaluation d'outils pharmacologiques pour RCPG orphelin GPR22
Publication date :
27 January 2015
Number of pages :
A0
Event name :
2015 GIGA Day: Current Advances in Medical Genetics and Genomics
