Reference : Comparison of the Sequences of Class a β-lactamase and of the Secondary Structure Ele...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/81190
Comparison of the Sequences of Class a β-lactamase and of the Secondary Structure Elements of Penicillin-Recognizing Proteins
English
Joris, Bernard mailto [Université de Liège - ULiège > > Laboratoire d'Enzymologie et Laboratoire de Cristallographie, Centre d'Ingénierie des Protéines > >]
Ledent, P. [Université de Liège - ULiège > > Laboratoire d'Enzymologie et Laboratoire de Cristallographie, Centre d'Ingénierie des Protéines > >]
Dideberg, O. [Université de Liège - ULiège > > > > Laboratoire d'Enzymologie et Laboratoire de Cristallographie, Centre d'Ingénierie des Protéines > >]
Fonze, E. [Université de Liège - ULiège > > Laboratoire d'Enzymologie et Laboratoire de Cristallographie, Centre d'Ingénierie des Protéines > >]
Lamotte-Brasseur, Josette mailto [Université de Liège - ULiège > > Laboratoire d'Enzymologie et Laboratoire de Cristallographie, Centre d'Ingénierie des Protéines > >]
Kelly, J. A. [University of Connecticut - UCONN > > Biochemistry and Biophysics > >]
Ghuysen, Jean-Marie [Université de Liège - ULiège > > > > Laboratoire d'Enzymologie et Laboratoire de Cristallographie, Centre d'Ingénierie des Protéines > >]
Frère, Jean-Marie mailto [Université de Liège - ULiège > > Centre d'ingénierie des protéines >]
Nov-1991
Antimicrobial Agents and Chemotherapy
American Society for Microbiology (ASM)
35
11
2294-2301
Yes (verified by ORBi)
International
0066-4804
1098-6596
Washington
DC
[en] Amino Acid Sequence ; Bacterial Proteins* ; Carrier Proteins/analysis ; Gram-Negative Bacteria/enzymology ; Hexosyltransferases* ; Molecular Sequence Data ; Muramoylpentapeptide Carboxypeptidase/analysis ; Penicillin-Binding Proteins ; Penicillins/analysis* ; Peptidyl Transferases* ; Protein Conformation ; Streptomyces/enzymology ; X-Ray Diffraction ; beta-Lactamases/analysis ; beta-Lactamases/chemistry*
[en] The sequences of class A beta-lactamases were compared. Four main groups of enzymes were distinguished: those from the gram-negative organisms and bacilli and two distinct groups of Streptomyces spp. The Staphylococcus aureus PC1 enzyme, although somewhat closer to the enzyme from the Bacillus group, did not belong to any of the groups of beta-lactamases. The similarities between the secondary structure elements of these enzymes and those of the class C beta-lactamases and of the Streptomyces sp. strain R61 DD-peptidase were also analyzed and tentatively extended to the class D beta-lactamases. A unified nomenclature of secondary structure elements is proposed for all the penicillin-recognizing enzymes.
Centre d'Ingénierie des Protéines - CIP
Fonds de la Recherche Scientifique Médicale - FRSM
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/81190

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