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Ghuysen Jean-Marie

Université de Liège - ULiège

See author's contact details
Main Referenced Co-authors
Frère, Jean-Marie  (118)
Leyh-Bouille, Mélina (56)
Joris, Bernard  (49)
Distèche, Martine  (48)
Dusart, Jean (44)
Main Referenced Keywords
kinetics (47); streptomyces/*enzymology (33); carboxypeptidases/*metabolism (28); amino acid sequence (23); chromatography (21);
Main Referenced Unit & Research Centers
CIP - Centre d'Ingénierie des Protéines - ULiège [BE] (68)
Centre de Recherches pour la pénicilline et les autres antibiotiques (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (280)
Microbiology (162)
Pharmacy, pharmacology & toxicology (15)
Chemistry (13)
Biotechnology (3)

Publications (total 332)

The most downloaded
8244 downloads
Ghuysen, J.-M. (1975). La paroi bactérienne. In F. Gasser (Ed.), Bactéries, bactériophages : cours de l'Institut Pasteur (pp. 125-148). Ediscience-MacGraw-Hill. https://hdl.handle.net/2268/91686

The most cited

894 citations (Scopus®)

Ambler, R. P., Coulson, A. F. W., Frère, J.-M., Ghuysen, J.-M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., & Waley, S. G. (15 May 1991). A standard numbering scheme for the class A beta-lactamases. Biochemical Journal, 276 (Pt 1), 269-270. doi:10.1042/bj2760269 https://hdl.handle.net/2268/81167

Theses and Dissertations

Post-doctoral thesis

Ghuysen, J.-M. (1957). Activités bactériolytiques de l’actinomycétine de streptomyces albus G [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/98882

Doctoral thesis

Ghuysen, J.-M. (1951). Etude de l’hétérogénéité de l’acide ribonucléique de la levure [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/98886

Books published as author or co-author

Ghuysen, J.-M., & Hackenbeck, R. (1994). Bacterial cell wall. Amesterdam, Netherlands: Elsevier.

Ghuysen, J.-M. (1977). E. R. Squibb Lectures on Chemistry of Microbial Products. The Bacterial DD-carboxypeptidase Enzyme System: A New Insight into the Mode of Action of Penicillin. Tokyo, Japan: University of Tokyo Press.

Ghuysen, J.-M. (1977). The bacterial DD-carboxypeptidase-transpeptidase enzyme system : a new insight into the mode of action of penicillin. Tokyo, Japan: University of Tokyo Press.

Book chapters and contributions to collective works

Contributions to collective works

Ghuysen, J.-M. (2004). Zinc D-Ala-D-Ala carboxypeptidase (Streptomyces). In A. J. Barret, N. D. Rawling, ... J. F. Woessner (Eds.), Handbook of Proteolytic Enzymes. vol 2 Cysteine, Serine and Threonine Peptidases (2ème éd, pp. 857-858). Academic Press.

Ghuysen, J.-M. (2004). Streptomyces K15 D-Ala-D-Ala transpeptidase. In A. J. Barret, N. D. Rawling, ... J. F. Woessner (Eds.), Handbook of Proteolytic Enzymes. vol 2 Cysteine, Serine and Threonine Peptidases (2ème éd, pp. 1956-1959). Academic Press.

Ghuysen, J.-M., & Frère, J.-M. (2004). B-Lactam Antibiotics. In Encyclopedic Reference of Molecular Pharmacology (pp. 679-683). Springer.

Ghuysen, J.-M. (1998). Zinc D-Ala-D-Ala carboxypeptidase. In A. J. Barrett, N. D. Rawlings, ... J. F. Woessner, Handbook of Proteolytic Enzymes (pp. 1354-1356). Academic Press.

Ghuysen, J.-M., & Dive, G. (1994). Biochemistry of the penicilloyl serine transferases. In J.-M. Ghuysen & R. Hackenbeck (Eds.), Bacterial cell wall (pp. 103-129). Amesterdam, Netherlands: Elsevier. doi:10.1016/S0167-7306(08)60409-3

Joris, B., Hardt, K., & Ghuysen, J.-M. (1994). Induction of β-lactamase and low-affinity penicillin binding protein 2' synthesis in gram-positive bacteria. In J.-M. Ghuysen & R. Hakenbeck (Eds.), Bacterial Cell Wall. vol 27 (pp. 505-515). Elsevier. doi:10.1016/S0167-7306(08)60427-5
Peer reviewed

Englebert, S., El Kharroubi, A., Piras, G., Joris, B., Coyette, J., Nguyen-Distèche, M., & Ghuysen, J.-M. (1993). Modular Design of the Bi(multi?) functional penicillin-binding proteins. In De pedro, J. V. Höltje, ... W. Loffelhardt (Eds.), Bacterial Growth & Lysis Metabolism and Structure of the Bacterial Sacculus (pp. 319-333). New York, United States: Plenum Press.
Peer reviewed

El Kharroubi, A., Jacques, P., Piras, G., Coyette, J., & Ghuysen, J.-M. (1988). Characterization of the Trypsin-Solubilized Penicillin-Binding Proteins of Enterococcus hirae (Streptococcus faecium). In P. Actor, L. Daneo-Moore, M. L. Higgins, M. R. J. Salton, ... G. D. Schokman (Eds.), Antibiotic Inhibition of Bacterial Cell Surface Assembly and Function (pp. 367-376). Washington, United States - District of Columbia: American Society for Microbiology.

Jacques, P., El Kharroubi, A., Joris, B., Dussenne, B., Thonon, F., Piras, G., Coyette, J., & Ghuysen, J.-M. (1988). Purification and Characterization of a β-lactam-Resistant Penicillin-Binding Protein from Enterococcus hirae (Streptococcus faecium). In P. Actor, L. Daneo-Moore, M. L. Higgins, M. R. J. Salton, ... G. D. Shockman (Eds.), Antibiotic Inhibition of Bacterial Cell Surface Assembly and Function (pp. 377-381). Washington, United States - District of Columbia: American Society for Microbiology.

Ghuysen, J.-M. (1987). The D-alanyl-D-alanine-cleaving peptidases and β-lactamases. Structure and mechanism. In J. M. Cardoso Duarte, L. J. Archer, A. T. Bull, ... G. Holt (Eds.), Perspectives in Biotechnology (pp. 67-95). Springer. doi:10.1007/978-1-4613-1883-5_6
Peer reviewed

Ghuysen, J.-M., Nguyen-Distèche, M., & Rousset, A. (1986). β-Lactam-induced Proteus L-forms. In S. Madoff (Ed.), The Bacterial L-Forms, vol. 17 (Department of Medecine and Bacteriology, Massachusetts General Hospital, pp. 127-162). New-York, United States - New York: Marcel Dekker, Inc.

Ghuysen, J.-M. (1984). Exploration of active sites of DD-peptidases. In W. Paton (Ed.), J. Mitchel (Ed.), P. Turner (Ed.), C. Padgham (Other coll.), ... E. Aschcroft (Other coll.), Iuphar 9th International Congress of Pharmacology, London 1984. Proceedings. Scientific & Medical Division, Macmillan Press.

Coyette, J., Somzé, A., Briquet, J.-J., Ghuysen, J.-M., & Fontana, R. (1983). Function of Penicillin-binding protein 3 in Streptococcus Faecium. In R. Hakenbeck, J.-V. Höltje, ... H. Labischinski (Eds.), The Target Penicillin : the Murein Sacculus of Bacterial Cell Walls Architecture and Growth : Proceedings (pp. 523-529). Walter de Gruyter & Co.

Charlier, P., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). The active site of the D-alanyl-D-Alanine-cleaving peptidase. In R. Hakenbeck, J. V. Höltje, ... H. Labischinski (Eds.), Target of Penicillin: The Murein Sacculus of Bacterial Cell Walls, Architecture and Growth (pp. 369-386). De Gruyter.

Charlier, P., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). The active sites of the D-alanyl-D-alanine-cleaving peptidases. In R. Hakenbeck, J.-V. Höltje, ... H. Labischinski (Eds.), The Target Penicillin : the Murein Sacculus of Bacterial Cell Walls Architecture and Growth : Proceedings (pp. 369-386). Berlin, Germany: Walter de Gruyter & Co.
Peer reviewed

Ghuysen, J.-M., Charlier, P., Coyette, J., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). Instrinct Resistance to beta-lactam antibiotics at the level of the enzyme sites. Many challenges, some achievements. In B. Wiedemann, J.-M. Guysen, K. H. Spitzy, K. Karrer, S. Brayer, R. Lenzhofer, K. Moser, H. Pichler, ... H. Rainer (Eds.), Symposium Mechanisms of resistance to beta-lactam antibiotics : Proceedings.
Peer reviewed

Ghuysen, J.-M., Frère, J.-M., Ley-Bouille, M., & Dideberg, O. (1981). The d-alanyl-d-Ala peptidases. Mechanism of action of penicillins and delta-3-cephalosporins. In M. Salton & G. D. Shockman (Eds.), Beta-Lactam Antibiotics: Mode of Action, New Development, and Future Prospects (pp. 127-152). New York, United States - New York: Academic Press.

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Dideberg, O., Lamotte-Brasseur, J., Perkins, H. R., & De Coen, J.-L. (1981). Penicillins and Δ3-cephalosporins as inhibitors and mechanism-based inactivators of D-alanyl-D-Ala peptidases. In A. S. V. Burgen & G. C. K. Roberts (Eds.), Topics in molecular pharmacology (pp. 64-96). Elsevier.
Peer reviewed

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Coyette, J., Duez, C., Joris, B., Dusart, J., Nguyen-Distèche, M., DideberG, O., Charlier, P., Knox, J. R., Kelly, J. A., Moews, P. C., & DeLucia, M. L. (1981). Mechanistic properties and functioning of DD-carboxypeptidase. In S. Mitsuhashi (Ed.), β-Lactam Antbiotics (pp. 185-202). Tokyo, Japan: Japan Scientific Society Press, Springer.

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., & Dideberg, O. (1981). Mode of action of penicillins and Δ3-cephalosporins. On the active centers of serine and zinc(2+) D-alanyl-D-Ala peptidases. In R. N. Ondarza & T. P. Singer (Eds.), Molecular basis of drug action: proceedings of the International Symposium on Molecular Basis of Drug Action, held in Querétaro, Mexico, October 13-16, 1980 (pp. 3-30). Elsevier.
Peer reviewed

Frère, J.-M., Duez, C., Dusart, J., Coyette, J., Leyh-Bouille, M., Ghuysen, J.-M., Dideberg, O., & Knox, J. (1980). Mode of action of B-lactam antibiotics at the molecular level. In M. Sandler, Enzyme inhibitors as drugs (pp. 183-207). Macmillan.
Peer reviewed

Charlier, P., Coyette, J., Dideberg, O., Duez, C., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Leyh-Bouille, M., & Nguyen-Distèche, M. (1980). On the Active Centers of Serine and Zn II DD-carboxyppetidases. In G. I. Gregory (Ed.), Recent advances in the Chemistry of beta-lactam antibiotics (pp. 184-202). London, United Kingdom: The Royal Society of Chemistry.

Ghuysen, J.-M. (1980). Antibiotics and peptidoglycan metabolism. In P. G. Sammes (Ed.), Topics in Antibiotic Chemistry. vol 5 (pp. 9-117). Ellis Horwood Ltd.

Ghuysen, J.-M. (1979). Interaction between B-lactam antibiotics and the enzymes of the wall peptidoglycan crosslinking system. In J. M. T. Hamilton-Miller, Beta-lactamases (pp. 181-204). Londres, United Kingdom: Academic press.

Marquet, A., Nguyen-Distèche, M., Leyh-Bouille, M., & Ghuysen, J.-M. (1978). Purification of DD-carboxypeptidases from Streptomyces strains R61 and K15 by antigen-antibody affinity chromatography. In O. Hoffmann-Ostenhof (Ed.), Affinity chromatography : biospecific sorption, the first extensive compendium on affinity chromatography as applied to biochemistry and immunochemistry (pp. 251-255). Elsevier.
Peer reviewed

Ghuysen, J.-M. (1977). Biosynthesis and assembly of bacterial cell walls. In G. Poste & G. L. Nicolson (Eds.), The synthesis, assembly and turnover of celle surface components (pp. 463-595). Elsevier.

Frère, J.-M., Leyh-Bouille, M., Dusart, J., Coyette, J., & Ghuysen, J.-M. (1976). Penicillin-transpeptidase interaction. In A. Loffett, J. Christophe, ... M. Svoboda, Peptides 1976: proceedings of the Fourteenth European Peptide Symposium, Wepion, Belgium, April 11-17, 1976 (pp. 385-399). Bruxelles, Belgium: Editions Universelles.
Peer reviewed

Frère, J.-M., Leyh-Bouille, M., Ghuysen, J.-M., Nieto, M., & Perkins, H. R. (1976). [51] Exocellular dd-carboxypeptidases-transpeptidases from Streptomyces. In L. Lorand (Ed.), Part B: Proteolytic Enzymes (pp. 610-636). Academic Press. doi:10.1016/S0076-6879(76)45054-1
Peer reviewed

Ghuysen, J.-M. (1975). La paroi bactérienne. In F. Gasser (Ed.), Bactéries, bactériophages : cours de l'Institut Pasteur (pp. 125-148). Ediscience-MacGraw-Hill.

Ghuysen, J.-M., Perkins, H., Frère, J.-M., & Nieto, M. (1974). Antibiotic action on enzymes involved in peptidoglycan synthesis. In H. Sund, Protein-ligand interactions : proceedings of a symposium held at the University of Konstanz (pp. 372-384). Konstanz, Germany: De Gruyter.
Peer reviewed

Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Marquet, A., Perkins, H. R., & Nieto, M. (1974). The penicillin Target in Bacteria. In B. Spencer (Ed.), Industrial Aspects of Biochemistry (FEBS Proceedings) (pp. 579-605). Elsevier. doi:10.1002/food.19750190412
Peer reviewed

Ghuysen, J.-M., Leyh-Bouille, M., Perkins, H.-R., & Nieto, M. (1973). Bacterial Peptidoglycans in Relation to the Membrane and the Mechanism of Action of Penicillin. In Z. Vanek, Z. Hostalek, ... J. Cudlin (Eds.), Genetics of industrial microorganisms. Bacteria (pp. 297-316). Prague, Czechia: Academia.

Dusart, J., Marquet, A., & Ghuysen, J.-M. (1973). Exocellular and membrane-bound transpeptidases in Streptomyces. In 1st International Congress for Bacteriology, Jerusalem, 2-7 September, 1973. Abstracts. Vol. II. Free papers (pp. 176-177).

Ghuysen, J.-M. (1973). Biosynthesis of Peptidoglycan. In L. Dekker (Ed.), The Bacterial Membranes and Walls (pp. 37-130). New-York, United States: Dekker.

Perkins, H. R., Ghuysen, J.-M., Nieto, M., Leyh-Bouille, M., & Frère, J.-M. (1973). DD-carboxypeptidases/Transpeptidases and Penicillin Action. In 1st International Congress for Bacteriology, Jerusalem, 2-7 September, 1973. Abstracts. Vol I. Symposia.

Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Perkins, H. R., & Nieto, M. (1972). The Streptomyces DD-carboxypeptidase-transpeptidase system as a model for the study of penicillin action. In P. Pratesi (Ed.), Medicinal Chemistry : Special contributions - Milan 1972 (pp. 1-11). London, United Kingdom: Butterworths.

Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Johnson, K., Nakel, M., Coyette, J., Perkins, H., & Nieto, M. (1972). Streptomyces DD carboxypeptidases-transpeptidases and mechanism of action of penicillin. In E. Munoz, Molecular mechanisms of antibiotic action on protein biosynthesis and membranes (pp. 406-426). Elsevier.
Peer reviewed

Ghuysen, J.-M. (1971). Bacterial walls and membranes. In Z. M. Bacq, Functions of Subcellular Structures (pp. 143-152). Oxford, United States - New York: Pergamon Press.

Ghuysen, J.-M., Leyh-Bouille, M., Nakel, M., Dusart, J., Johnson, K., & Frère, J.-M. (1971). DD-carboxypeptidases and Mechanism of Action of Penicillin. In E. Muñoz, F. García-Ferrandiz, ... D. Vazquez (Eds.), Molecular mechanisms of antibiotic action on protein biosynthesis and membranes. Proceedings of a symposium held at the University of Granada (Spain) June 1st-4th (pp. 51-51). Elsevier.

Leyh-Bouille, M., Ghuysen, J.-M., Bonaly, R., Nueto, M., Perkins, H. R., Schliefer, K. H., & Kandler, O. (1970). Extracellular, penicillin-resistant DD-carboxypeptidase from Streptomyces SP [abstract]. In Xe Congresso Internacional de Microbiologica - Resumenes - abstracts - résumés (pp. 33).

Ghuysen, J.-M., & Leyh-Bouille, M. (1970). Bacterial Wall Peptidoglycans; Mecanism of Action of Penicillin. In Genetics of Industrial Microorganisms : abstact book (pp. 9-1).

Ghuysen, J.-M. (1970). Functions of Subcellular Structures. In Z. M. Bacq (Ed.), Fundamentals of Biochemical Pharmacology (pp. 143-184). Pergamon Press.

Guinand, M., Ghuysen, J.-M., Leyh-Bouille, M., Coyette, J., & ven Heijenoort, J. (1969). A streptomyces Carboxypeptidase Active on. In 6th FEBS Meeting Abstracts.

Ghuysen, J.-M. (1969). Biochemistry of the wall peptidoglycan in the Procaryotic Cells in relation to the membrane. In 6th FEBS Meeting Abstracts.

Ghuysen, J.-M., Leger, G., & Dierickx, L. (1958). Production et isolement du complexe protéolytique de streptomyces spp., Son application à l'épilage et au confitage simultanés des peaux. In XXXIème Congrès International de Chimie Industrielle (pp. 671-674).
Peer reviewed

Welsch, M., Ghuysen, J.-M., & Castermans, A. (1956). Multiplicity of bacteriolytic agents in actinomycetin. In C. Liébecq (Ed.), Proceedings of the third international congress of biochemistry, Brussels 1955 (pp. 413-415). New York, United States - New York: Academic Press.

Contributions in scientific journals

Articles

Goffin, C., & Ghuysen, J.-M. (December 2002). Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: Presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent. Microbiology and Molecular Biology Reviews, 66 (4), 702-738. doi:10.1128/MMBR.66.4.702-738.2002
Peer Reviewed verified by ORBi

Marrec-Fairley, M., Piette, A., Gallet, X., Brasseur, R., Hara, H., Fraipont, C., Ghuysen, J.-M., & Nguyen-Disteche, M. (September 2000). Differential Functionalities of Amphiphilic Peptide Segments of the Cell-Septation Penicillin-Binding Protein 3 of Escherichia Coli. Molecular Microbiology, 37 (5), 1019-1031. doi:10.1046/j.1365-2958.2000.02054.x
Peer Reviewed verified by ORBi

Terrak, M., Ghosh, T. K., van Heijenoort, J., Van Beeumen, J., Lampilas, M., Aszodi, J., Ayala, J. A., Ghuysen, J.-M., & Nguyen-Distèche, M. (October 1999). The Catalytic, Glycosyl Transferase and Acyl Transferase Modules of the Cell Wall Peptidoglycan-Polymerizing Penicillin-Binding Protein 1b of Escherichia Coli. Molecular Microbiology, 34 (2), 350-364. doi:10.1046/j.1365-2958.1999.01612.x
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Goffin, C. (October 1999). Lack of Cell Wall Peptidoglycan Versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly. Antimicrobial Agents and Chemotherapy, 43 (10), 2339-2344. doi:10.1128/aac.43.10.2339
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (03 December 1998). La résistance bactérienne aux antibiotiques, un modèle exemplaire d'évolution moléculaire dirigée. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 60 (4), 287-294.
Peer Reviewed verified by ORBi

Goffin, C., & Ghuysen, J.-M. (December 1998). Multimodular Penicillin-Binding Proteins: An Enigmatic Family of Orthologs and Paralogs. Microbiology and Molecular Biology Reviews, 62 (4), 1079-1093. doi:10.1128/mmbr.62.4.1079-1093.1998
Peer Reviewed verified by ORBi

Raze, D., Dardenne, O., Hallut, S., Martinez-Bueno, M., Coyette, J., & Ghuysen, J.-M. (March 1998). The Gene Encoding the Low-Affinity Penicillin-Binding Protein 3r in Enterococcus Hirae S185r Is Borne on a Plasmid Carrying Other Antibiotic Resistance Determinants. Antimicrobial Agents and Chemotherapy, 42 (3), 534-539. doi:10.1128/aac.42.3.534
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1998). La paroi bactérienne et la résistance à la pénicilline: faits, questions et espoirs. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 153 (4), 235-41.
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1998). La résistance bactérienne aux antibiotiques, un modèle exemplaire d'évolution moléculaire dirigée. Revue Médicale de Liège, 53 (9), 529-531.
Peer reviewed

Zhao, G., Duez, C., Forceille, C., Rhazi, N., Klein, D., Ghuysen, J.-M., Frère, J.-M., & Lepage, S. (15 October 1997). Site-Directed Mutagenesis of the Actinomadura R39 DD-Peptidase. Biochemical Journal, 327 (2), 377-381. doi:10.1042/bj3270377
Peer Reviewed verified by ORBi

Adam, M., Fraipont, C., Rhazi, N., Nguyen-Disteche, M., Lakaye, B., Frère, J.-M., Devreese, B., Van Beeumen, J., van Heijenoort, Y., van Heijenoort, J., & Ghuysen, J.-M. (October 1997). The Bimodular G57-V577 Polypeptide Chain of the Class B Penicillin-Binding Protein 3 of Escherichia Coli Catalyzes Peptide Bond Formation from Thiolesters and Does Not Catalyze Glycan Chain Polymerization from the Lipid II Intermediate. Journal of Bacteriology, 179 (19), 6005-6009. doi:10.1128/jb.179.19.6005-6009.1997
Peer Reviewed verified by ORBi

Lepage, S., Dubois, P., Ghosh, T.-K., Joris, B., Mahapatra, S., Kundu, M., Basu, J., Chakrabarti, P., Cole, S.-T., Nguyen-Distèche, M., & Ghuysen, J.-M. (July 1997). Dual Multimodular Class a Penicillin-Binding Proteins in Mycobacterium Leprae. Journal of Bacteriology, 179 (14), 4627-4630. doi:10.1128/jb.179.14.4627-4630.1997
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Charlier, P., Coyette, J., Duez, C., Fonzé, E., Fraipont, C., Goffin, C., Joris, B., & Nguyen-Distèche, M. (1997). Penicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: facts, doubts and hopes. International Journal of Antimicrobial Agents, 8 (1), 45-60. doi:10.1016/S0924-8579(96)00358-5
Peer Reviewed verified by ORBi

Hardt, K., Joris, B., Lepage, S., Brasseur, R., Lampen, J. O., Frère, J.-M., Fink, A. L., & Ghuysen, J.-M. (1997). The Penicillin sensory transducer, blar, involved in the inducibility of beta-lactamase synthesis in bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle. Molecular Microbiology, 23 (5), 935-944. doi:10.1046/j.1365-2958.1997.2761642.x
Peer Reviewed verified by ORBi

Goffin, C., Fraipont, C., Ayala, J., Terrak, M., Nguyen-Distèche, M., & Ghuysen, J.-M. (September 1996). The non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia Coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the folded structure. Journal of Bacteriology, 178 (18), 5402-5409. doi:10.1128/jb.178.18.5402-5409.1996
Peer Reviewed verified by ORBi

Mollerach, M. E., Partoune, P., Coyette, J., & Ghuysen, J.-M. (March 1996). Importance of the E-46-D-160 Polypeptide Segment of the Non-Penicillin-Binding Module for the Folding of the Low-Affinity, Multimodular Class B Penicillin-Binding Protein 5 of Enterococcus Hirae. Journal of Bacteriology, 178 (6), 1774-1775. doi:10.1128/jb.178.6.1774-1775.1996
Peer Reviewed verified by ORBi

Basu, J., Mahapatra, S., Kundu, M., Mukhopadhyay, S., Nguyen-Distèche, M., Dubois, P., Joris, B., Van Beeumen, J., Cole, S.-T., Chakrabarti, P., & Ghuysen, J.-M. (March 1996). Identification and overexpression in Escherichia coli of a Mycobacterium leprae gene, pon1, encoding a high-molecular-mass class A penicillin-binding protein, PBP1. Journal of Bacteriology, 178 (6), 1707-1711. doi:10.1128/jb.178.6.1707-1711.1996
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Knill, C., Kennedy, J., & Hakenbeck, R. (1996). Bacterial cell wall. Carbohydrate Polymers, 29 (3), 294.
Peer Reviewed verified by ORBi

Chavagnat, F., Duez, C., Guinand, M., Potin, P., Barbeyron, T., Henrissat, B., Wallach, J., & Ghuysen, J.-M. (1996). Cloning, sequencing and overexpression in Escherichia coli of the alginate lyase-encoding aly gene of Pseudomonas alginovora: identification of three classes of alginate lyases. Biochemical Journal, 319 (Pt 2), 575-583. doi:10.1042/bj3190575
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Charlier, P., Coyette, J., Duez, C., Fonze, E., Fraipont, C., Joris, B., Nguyen-Distèche, M., & Goffin, C. (1996). Penicillin and Beyond: Evolution, Protein Fold, Multimodular Polypeptides, and Multiprotein Complexes. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 2 (2, Summer), 163-175. doi:10.1089/mdr.1996.2.163
Peer Reviewed verified by ORBi

Malissard, M., Chavagnat, F., Duez, C., Vacheron, M.-J., Guinand, M., Michel, G., & Ghuysen, J.-M. (15 February 1995). Overproduction and properties of the mannuronate alginate lyase AlxMB. FEMS Microbiology Letters, 126 (2), 105-111. doi:10.1016/0378-1097(94)00536-Z
Peer Reviewed verified by ORBi

Grandchamps, J., Nguyen-Distèche, M., Damblon, C., Frère, J.-M., & Ghuysen, J.-M. (1995). Streptomyces K15 active-site serine DD-transpeptidase: specificity profile for peptide, thiol ester and ester carbonyl donors and pathways of the transfer reactions. Biochemical Journal, 307 (Pt 2), 335-339. doi:10.1042/bj3070335
Peer Reviewed verified by ORBi

Delfosse, P., Ongena, M., Jacques, P., Ghuysen, J.-M., & Thonart, P. (1995). Pyoverdine-mediated uptake of iron in Pseudomonas putida BTP1 : involvement of a 100 KD IROMP. Archives Internationales de Physiologie et de Biochimie, 103 (B39).

Ghuysen, J.-M. (October 1994). Molecular Structures of Penicillin-Binding Proteins and Beta-Lactamases. Trends in Microbiology, 2 (10), 372-380. doi:10.1016/0966-842X(94)90614-9
Peer Reviewed verified by ORBi

Duez, C., Piron-Fraipont, C., Joris, B., Dusart, J., Urdea, M.-S., Martial, J., Frère, J.-M., & Ghuysen, J.-M. (15 September 1994). Erratum for : primary structure of the streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene. European Journal of Biochemistry, 224 (3), 1079. doi:10.1111/j.1432-1033.1994.01079.x
Peer Reviewed verified by ORBi

Fanuel, L., Granier, B., Wilkin, J.-M., Bellefroid-Bourguignon, C., Joris, B., Knowles, J., Komives, E., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (29 August 1994). The Precursor of the Streptomyces R61 Dd-Peptidase Containing a C-Terminal Extension Is Inactive. FEBS Letters, 351 (1), 49-52. doi:10.1016/0014-5793(94)00822-1
Peer Reviewed verified by ORBi

Ayala, J., Goffin, C., Nguyen-Distèche, M., & Ghuysen, J.-M. (15 August 1994). Site-directed mutagenesis of penicillin-binding protein 3 of Escherichia coli: role of Val-545. FEMS Microbiology Letters, 121 (2), 251-256. doi:10.1111/j.1574-6968.1994.tb07106.x
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Lamotte-Brasseur, J., Joris, B., & Shockman, G. D. (28 March 1994). Binding Site-Shaped Repeated Sequences of Bacterial Wall Peptidoglycan Hydrolases. FEBS Letters, 342 (1), 23-28. doi:10.1016/0014-5793(94)80577-6
Peer Reviewed verified by ORBi

Fraipont, C., Adam, M., Nguyen-Distèche, M., Keck, W., Van Beeumen, J., Ayala, J. A., Granier, B., Hara, H., & Ghuysen, J.-M. (10 February 1994). Engineering and Overexpression of Periplasmic Forms of the Penicillin-Binding Protein 3 of Escherichia Coli. Biochemical Journal, 298 (1), 189-195. doi:10.1042/bj2980189
Peer Reviewed verified by ORBi

Englebert, S., Charlier, P., Fonze, E., To'th, Y., Vermeire, M., Van Beeumen, J., Grandchamps, J., Hoffmann, K., Leyh-Bouille, M., Nguyen-Distèche, M., & Ghuysen, J.-M. (1994). Crystallization and X-ray diffraction study of the Streptomyces K15 penicillin-binding DD-transpeptidase. Journal of Molecular Biology, 241 (2), 295-7. doi:10.1006/jmbi.1994.1504
Peer Reviewed verified by ORBi

Dive, G., Dehareng, D., & Ghuysen, J.-M. (1994). Detailed Study of a Molecule in a Molecule N-Acetyl-L-Tryptophanamide in a Active-Site Model of Alpha-Chymotrypsin. Journal of the American Chemical Society, 116 (6), 2548-2556. doi:10.1021/ja00085a039
Peer Reviewed verified by ORBi

Granier, B., Jamin, M., Adam, M., Galleni, M., Lakaye, B., Zorzi, W., Grandchamps, J., Wilkin, J.-M., Fraipont, C., Joris, B., Duez, C., Nguyen-Distèche, M., Coyette, J., Leyh-Bouille, M., Dusart, J., Christians, L., Frère, J.-M., & Ghuysen, J.-M. (1994). Serine-Type D-Ala-D-Ala Peptidases and Penicillin-Binding Proteins. Methods in Enzymology, 244, 249-266. doi:10.1016/0076-6879(94)44021-2
Peer Reviewed verified by ORBi

Goffin, C., Ayala, J. A., Nguyen-Distèche, M., & Ghuysen, J.-M. (01 November 1993). Site-directed mutagenesis of dicarboxylic acid residues of the penicillin-binding module of the Escherichia coli penicillin-binding protein 3. FEMS Microbiology Letters, 113 (3), 247-251. doi:10.1111/j.1574-6968.1993.tb06522.x
Peer Reviewed verified by ORBi

Hourdou, M.-L., Guinand, M., Vacheron, M.-J., Denoroy, L., Duez, C., Englebert, S., Joris, B., Weber, G., Ghuysen, J.-M., & Michel, G. (01 June 1993). Characterization of the Sporulation-Related Gamma-D-Glutamyl-(L)Meso-Diaminopimelic-Acid-Hydrolysing Peptidase I of Bacillus Sphaericus NCTC 9602 as a Member of the Metallo(Zinc) Carboxypeptidase A Family. Modular Design of the Protein. Biochemical Journal, 292 (Pt 2), 563-570. doi:10.1042/bj2920563
Peer Reviewed verified by ORBi

Piras, G., Raze, D., el Kharroubi, A., Hastir, D., Englebert, S., Coyette, J., & Ghuysen, J.-M. (May 1993). Cloning and Sequencing of the Low-Affinity Penicillin-Binding Protein 3r-Encoding Gene of Enterococcus Hirae S185: Modular Design and Structural Organization of the Protein. Journal of Bacteriology, 175 (10), 2844-2852. doi:10.1128/jb.175.10.2844-2852.1993
Peer Reviewed verified by ORBi

Dehareng, D., Dive, G., & Ghuysen, J.-M. (1993). Analytical calculation of the electrostatic interaction energy within the CNDO framework. International Journal of Quantum Chemistry, 46 (6), 711-734. doi:10.1002/qua.560460605
Peer Reviewed verified by ORBi

Malissard, M., Duez, C., Guinand, M., Vacheron, M.-J., Michel, G., Marty, N., Joris, B., Thamm, I., & Ghuysen, J.-M. (1993). Sequence of a gene encoding a (poly ManA) alginate lyase active on Pseudomonas aeruginosa alginate. FEMS Microbiology Letters, 110 (1), 101-106. doi:10.1111/j.1574-6968.1993.tb06302.x
Peer Reviewed verified by ORBi

Dehareng, D., Dive, G., & Ghuysen, J.-M. (1993). Polarization-corrected electrostatic potentials of aromatic compounds. Journal of the American Chemical Society, 115 (15), 6877-6882. doi:10.1021/ja00068a052
Peer Reviewed verified by ORBi

Dive, G., Dehareng, D., & Ghuysen, J.-M. (1993). Energy Analysis on Small to Medium Sized H-Bonded Complexes. Theoretica Chimica Acta, 85 (6), 409-421. doi:10.1007/BF01112981
Peer reviewed

Palomeque-Messia, P., Quittre, V., Leyh-Bouille, M., Nguyen-Distèche, M., Gershater, C. J., Dacey, I. K., Dusart, J., Van Beeumen, J., & Ghuysen, J.-M. (15 November 1992). Secretion by Overexpression and Purification of the Water-Soluble Streptomyces K15 Dd-Transpeptidase/Penicillin-Binding Protein. Biochemical Journal, 288 (1), 87-91. doi:10.1042/bj2880087
Peer Reviewed verified by ORBi

Zhu, Y., Englebert, S., Joris, B., Ghuysen, J.-M., Kobayashi, T., & Lampen, J.-O. (01 October 1992). Structure, function, and fate of the BlaR signal transducer involved in induction of β-lactamase in Bacillus licheniformis. Journal of Bacteriology, 174 (19), 6171-6178. doi:10.1128/jb.174.19.6171-6178.1992
Peer Reviewed verified by ORBi

Hadonou, A. M., Wilkin, J.-M., Varetto, L., Joris, B., Lamotte-Brasseur, J., Klein, D., Duez, C., Ghuysen, J.-M., & Frère, J.-M. (01 July 1992). Site-Directed Mutagenesis of the Streptomyces R61 Dd-Peptidase. Catalytic Function of the Conserved Residues around the Active Site and a Comparison with Class-a and Class-C Beta-Lactamases. European Journal of Biochemistry, 207 (1), 97-102. doi:10.1111/j.1432-1033.1992.tb17025.x
Peer Reviewed verified by ORBi

Bourguignon-Bellefroid, C., Joris, B., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (01 April 1992). Point Mutations of Two Arginine Residues in the Streptomyces R61 Dd-Peptidase. Biochemical Journal, 283 (1), 123-128. doi:10.1042/bj2830123
Peer Reviewed verified by ORBi

Granier, B., Duez, C., Englebert, S., Dusart, J., Dideberg, O., Van Beeumen, J., Frère, J.-M., Ghuysen, J.-M., & Lepage, S. (15 March 1992). Primary and Predicted Secondary Structures of the Actinomadura R39 Extracellular DD-Peptidase, a Penicillin-Binding Protein (PBP) Related to the Escherichia coli PBP4. Biochemical Journal, 282 (Pt 3), 781-788. doi:10.1042/bj2820781
Peer Reviewed verified by ORBi

Joris, B., Englebert, S., Chu, C.-P., Kariyama, R., Daneo-Moore, L., Shockman, G. D., & Ghuysen, J.-M. (15 March 1992). Modular Design of the Enterococcus Hirae Muramidase-2 and Streptococcus Faecalis Autolysin. FEMS Microbiology Letters, 91 (3), 257-264. doi:10.1016/0378-1097(92)90707-U
Peer Reviewed verified by ORBi

Hourdou, M.-L., Duez, C., Joris, B., Vacheron, M.-J., Guinand, M., Michel, G., & Ghuysen, J.-M. (01 March 1992). Cloning and nucleotide sequence of the gene encoding the γ-D-glutamyl-L-diamino acid endopeptidase II of Bacillus sphaericus. FEMS Microbiology Letters, 91 (2), 165-170. doi:10.1016/0378-1097(92)90678-H
Peer Reviewed verified by ORBi

Bourguignon-Bellefroid, C., Wilkin, J.-M., Joris, B., Aplin, R. T., Houssier, C., Prendergast, F. G., Van Beeumen, J., Ghuysen, J.-M., & Frère, J.-M. (01 March 1992). Importance of the Two Tryptophan Residues in the Streptomyces R61 Exocellular Dd-Peptidase. Biochemical Journal, 282 (Pt 2), 361-367. doi:10.1042/bj2820361
Peer Reviewed verified by ORBi

Hadonou, A. M., Jamin, M., Adam, M., Joris, B., Dusart, J., Ghuysen, J.-M., & Frère, J.-M. (01 March 1992). Importance of the His-298 Residue in the Catalytic Mechanism of the Streptomyces R61 Extracellular Dd-Peptidase. Biochemical Journal, 282 (Pt 2), 495-500. doi:10.1042/bj2820495
Peer Reviewed verified by ORBi

Lamotte-Brasseur, J., Jacob-Dubuisson, F., Dive, G., Frère, J.-M., & Ghuysen, J.-M. (10 February 1992). Streptomyces albus G serine β-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes. Biochemical Journal, 282 (Pt 1), 189-195. doi:10.1042/bj2820189
Peer Reviewed verified by ORBi

Dive, G., Dehareng, D., Culot, P., & Ghuysen, J.-M. (1992). Energy hypersurface local properties of the O2HF-1 rearrangement. Chemical Physics Letters, 195 (2-3), 189-193. doi:10.1016/0009-2614(92)86134-4
Peer Reviewed verified by ORBi

Dehareng, D., Dive, G., & Ghuysen, J.-M. (1992). Influence of the Counterpoise Correction on the Optimized Relativi Degrees of Freedom in the H-Bonded Complex Water-Formamide. Theoretica Chimica Acta, 81 (4-5), 281-290. doi:10.1007/BF01118568
Peer reviewed

Culot, P., Dive, G., Nguyen, V. H., & Ghuysen, J.-M. (1992). A quasi-Newton algorithm for first-odrer saddle-point location. Theoretica Chimica Acta, 82, 189-205. doi:10.1007/BF01113251

el Kharroubi, A., Jacques, P., Piras, G., Van Beeumen, J., Coyette, J., & Ghuysen, J.-M. (01 December 1991). The Enterococcus Hirae R40 Penicillin-Binding Protein 5 and the Methicillin-Resistant Staphylococcus Aureus Penicillin-Binding Protein 2' Are Similar. Biochemical Journal, 280 (Pt 2), 463-469. doi:10.1042/bj2800463
Peer Reviewed verified by ORBi

Joris, B., Ledent, P., Dideberg, O., Fonze, E., Lamotte-Brasseur, J., Kelly, J. A., Ghuysen, J.-M., & Frère, J.-M. (November 1991). Comparison of the Sequences of Class a β-lactamase and of the Secondary Structure Elements of Penicillin-Recognizing Proteins. Antimicrobial Agents and Chemotherapy, 35 (11), 2294-2301. doi:10.1128/AAC.35.11.2294
Peer Reviewed verified by ORBi

Palomeque-Messia, P., Englebert, S., Leyh-Bouille, M., Nguyen-Distèche, M., Duez, C., Houba, S., Dideberg, O., Van Beeumen, J., & Ghuysen, J.-M. (01 October 1991). Amino Acid Sequence of the Penicillin-Binding Protein/DD-Peptidase of Streptomyces K15. Predicted Secondary Structures of the Low Mr Penicillin-Binding Proteins of Class A. Biochemical Journal, 279 (Pt 1), 223-230. doi:10.1042/bj2790223
Peer Reviewed verified by ORBi

Lamotte-Brasseur, J., Dive, G., Dideberg, O., Charlier, P., Frère, J.-M., & Ghuysen, J.-M. (01 October 1991). Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G. Biochemical Journal, 279 (Pt 1), 213-221. doi:10.1042/bj2790213
Peer Reviewed verified by ORBi

Jacques, P., el Kharroubi, A., Van Beeumen, J., Piras, G., Coyette, J., & Ghuysen, J.-M. (01 August 1991). Mode of Membrane Insertion and Sequence of a 32-Amino Acid Peptide Stretch of the Penicillin-Binding Protein 4 of Enterococcus Hirae. FEMS Microbiology Letters, 66 (2), 119-123. doi:10.1111/j.1574-6968.1991.tb04851.x
Peer Reviewed verified by ORBi

Ambler, R. P., Coulson, A. F. W., Frère, J.-M., Ghuysen, J.-M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., & Waley, S. G. (15 May 1991). A standard numbering scheme for the class A beta-lactamases. Biochemical Journal, 276 (Pt 1), 269-270. doi:10.1042/bj2760269
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (March 1991). Recherche fondamentale et médecine. Revue Médicale de Liège, 46 (3), 115-122.
Peer reviewed

Dehareng, D., Dive, G., & Ghuysen, J.-M. (1991). Polarization correction to the electrostatic potential at the CNDO and the ab initio level. Influence of the basis set expansion. Theoretica Chimica Acta, 79 (2), 141-152. doi:10.1007/BF01127102
Peer reviewed

Lamotte, J., Dive, G., & Ghuysen, J.-M. (1991). Conformational analysis of β and γ-lactam antibiotics. European Journal of Medicinal Chemistry, 26 (1), 43-50. doi:10.1016/0223-5234(91)90211-5
Peer Reviewed verified by ORBi

Adam, M., Damblon, C., Jamin, M., Zorzi, W., Dusart, V., Galleni, M., El Kharroubi, A., Piras, G., Spratt, B. G., Keck, W., Coyette, J., Ghuysen, J.-M., NGuyen-Distèche, M., & Frère, J.-M. (1991). Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochemical Journal, 279 (Part 2), 601-604. doi:10.1042/bj2790601
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1991). Protéines liant la pénicilline et les B-lactamases. Mecanisme, structure et évolution. Journal de Pharmacie de Belgique, 46 (1), 7-8.
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1991). Serine β-lactamases and penicillin-binding proteins. Annual Review of Microbiology, 45, 37-67. doi:10.1146/annurev.mi.45.100191.000345
Peer Reviewed verified by ORBi

Piras, G., El Kharroubi, A., van Beeumen, J., Coeme, E., Coyette, J., & Ghuysen, J.-M. (01 December 1990). Characterization of an Enterococcus Hirae Penicillin-Binding Protein 3 with Low Penicillin Affinity. Journal of Bacteriology, 172 (12), 6856-6862. doi:10.1128/jb.172.12.6856-6862.1990
Peer Reviewed verified by ORBi

Urabe, H., Lenzini, M. V., Mukaide, M., Dusart, J., Nakano, M. M., Ghuysen, J.-M., & Ogawara, H. (01 November 1990). β-Lactamase expression in Streptomyces cacaoi. Journal of Bacteriology, 172 (11), 6427-6434. doi:10.1128/jb.172.11.6427-6434.1990
Peer Reviewed verified by ORBi

Jacob, F., Joris, B., Dideberg, O., Dusart, J., Ghuysen, J.-M., & Frère, J.-M. (October 1990). Engineering a Novel β-Lactamase by a Single Point Mutation. Protein Engineering, 4 (1), 79-86. doi:10.1093/protein/4.1.79
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (October 1990). Membrane Topology, Structure, and Functions of the Penicillin-Interactive Proteins. Biotechnology and Applied Biochemistry, 12 (5), 468-472. doi:10.1111/j.1470-8744.1990.tb00114.x
Peer Reviewed verified by ORBi

Duez, C., Lakaye, B., Houba, S., Dusart, J., & Ghuysen, J.-M. (01 September 1990). Cloning, Nucleotide Sequence and Amplified Expression of the Gene Encoding the Extracellular Metallo (Zn) Dd-Peptidase of Streptomyces Albus G. FEMS Microbiology Letters, 71 (1-2), 215-219. doi:10.1016/0378-1097(90)90059-Y
Peer Reviewed verified by ORBi

Piron-Fraipont, C., Lenzini, M. V., Dusart, J., & Ghuysen, J.-M. (1990). Transcriptional Analysis of the dd-Peptidase/Penicillin-Binding Protein-Encoding dac Gene of Streptomyces R61: Use of the Promoter and Signal Sequences in a Secretion Vector. Molecular and General Genetics, (223), 114-120. doi:10.1007/BF00315803
Peer Reviewed verified by ORBi

Lamotte-Brasseur, J., Dive, G., Dehareng, D., & Ghuysen, J.-M. (24 July 1990). Electrostatic potential maps at the quantum chemistry level of the active sites of the serine peptidases, α-chymotrypsin and subtilisin. Journal of Theoretical Biology, 145 (2), 183-98. doi:10.1016/S0022-5193(05)80124-9
Peer Reviewed verified by ORBi

Joris, B., Ledent, P., Kobayashi, T., Lampen, J.-O., & Ghuysen, J.-M. (15 June 1990). Expression in Escherichia Coli of the Carboxy Terminal Domain of the Blar Sensory-Transducer Protein of Bacillus Licheniformis as a Water-Soluble Mr 26,000 Penicillin-Binding Protein. FEMS Microbiology Letters, 58 (1), 107-113. doi:10.1016/0378-1097(90)90111-3
Peer Reviewed verified by ORBi

Joris, B., Dive, G., Henriques, A., Piggot, P. J., & Ghuysen, J.-M. (March 1990). The Life-Cycle Proteins Roda of Escherichia Coli and Spove of Bacillus Subtilis Have Very Similar Primary Structures. Molecular Microbiology, 4 (3), 513-517. doi:10.1111/j.1365-2958.1990.tb00618.x
Peer Reviewed verified by ORBi

Zhu, Y.-F., Curran, I. H. A., Joris, B., Ghuysen, J.-M., & Lampen, J. O. (01 February 1990). Identification of BlaR, the signal transducer for β-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 β-lactamase (class D) of Salmonella typhimurium. Journal of Bacteriology, 172 (2), 1137-1141. doi:10.1128/jb.172.2.1137-1141.1990
Peer Reviewed verified by ORBi

Houba, S., Willem, S., Duez, C., Molitor, C., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (December 1989). Nucleotide sequence of the gene encoding the active-site serine β-lactamase from Actinomadura R39. FEMS Microbiology Letters, 65 (3), 241-246. doi:10.1111/j.1574-6968.1989.tb03667.x
Peer Reviewed verified by ORBi

Laible, G., Hakenbeck, R., Sicard, M. A., Joris, B., & Ghuysen, J.-M. (01 October 1989). Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506. Molecular Microbiology, 3 (10), 1337-1348. doi:10.1111/j.1365-2958.1989.tb00115.x
Peer Reviewed verified by ORBi

El Kharroubi, A., Piras, G., Jacques, P., Szabo, I., Van Beeumen, J., Coyette, J., & Ghuysen, J.-M. (01 September 1989). Active-Site and Membrane Topology of the Dd-Peptidase/Penicillin-Binding Protein No. 6 of Enterococcus Hirae (Streptococcus Faecium) A.T.C.C. 9790. Biochemical Journal, 262 (2), 457-462. doi:10.1042/bj2620457
Peer Reviewed verified by ORBi

Dehareng, D., Dive, G., Lamotte-Brasseur, J., & Ghuysen, J.-M. (1989). Numerical computation of the electrostatic interaction energy between methanol and the dyad water-imidazole. Theoretica Chimica Acta, 76 (2), 85-94. doi:10.1007/BF00532126
Peer reviewed

Leyh-Bouille, M., Vanbeeumen, J., Renier-Pirlot, S., Joris, B., Nguyen-Distèche, M., & Ghuysen, J.-M. (1989). The Streptomyces K15 DD-peptidase/penicillin-binding protein. Active site and sequence of the N-terminal region. Biochemical Journal, 260 (2), 601-604. doi:10.1042/bj2600601
Peer Reviewed verified by ORBi

Kelly, J. A., Knox, J. R., Zhao, H. C., Frère, J.-M., & Ghuysen, J.-M. (1989). Crystallographic mapping of β-lactams bound to a D-alanyl-D-alanine peptidase target enzyme. Journal of Molecular Biology, 209 (2), 281-295. doi:10.1016/0022-2836(89)90277-5
Peer Reviewed verified by ORBi

Fraipont, C., Duez, C., Matagne, A., Molitor, C., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (1989). Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular β-lactamase of Actinomadura R39. Biochemical Journal, 262 (3), 849-854. doi:10.1042/bj2620849
Peer Reviewed verified by ORBi

Joris, B., Ghuysen, J.-M., Dive, G., Renard, A., Dideberg, O., Charlier, P., Frère, J.-M., Kelly, J. A., Boyington, J., Moews, P. C., & Knox, J. (01 March 1988). The Active-Site-Serine Penicillin-Recognizing Enzymes as Members of the Streptomyces R61 Dd-Peptidase Family. Biochemical Journal, 250 (2), 313-324. doi:10.1042/bj2500313
Peer Reviewed verified by ORBi

Kelly, J. A., Knox, J. R., Moews, P. C., Frère, J.-M., & Ghuysen, J.-M. (01 March 1988). Using X-ray diffraction results and computer graphics to design beta-lactams. Kansenshogaku zasshi, 62 Suppl, 182-191.
Peer Reviewed verified by ORBi

Ferreira, L. C., Schwarz, U., Keck, W., Charlier, P., Dideberg, O., & Ghuysen, J.-M. (15 January 1988). Properties and crystallization of a genetically engineered, water-soluble derivative of penicillin-binding protein 5 of Escherichia coli K12. European Journal of Biochemistry, 171 (1-2), 11-16. doi:10.1111/j.1432-1033.1988.tb13751.x
Peer Reviewed verified by ORBi

Bartholomé-De Belder, J., Nguyen-Distèche, M., Houba-Herin, N., Ghuysen, J.-M., Maruyama, I. N., Hara, H., Hirota, Y., & Inouye, M. (1988). Overexpression, solubilization and refolding of a genetically engineered derivative of the penicillin-binding protein 3 of Escherichia coli K12. Molecular Microbiology, 2 (4), 519-525. doi:10.1111/j.1365-2958.1988.tb00058.x
Peer Reviewed verified by ORBi

Curtis, N. A. C., Bennett, P. M., Nicholas, R., Spratt, B. G., Jacoby, G. A., Levesque, R. C., Tomasz, A., Ghuysen, J.-M., Courvalin, P., Broomesmith, J., Wiedemann, B., Mitsuitashi, S., Richmond, M. H., Franklin, T. J., & Bush, K. (1988). Biochemistry of beta-lactamases and penicillin-binding proteins - Discussion. Reviews of Infectious Diseases, 10 (4), 739-742.
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1988). Bacterial Active-Site Serine Penicillin-Interactive Proteins and Domains: Mechanism, Structure, and Evolution. Reviews of Infectious Diseases, 10 (4), 726-732. doi:10.1093/clinids/10.4.726
Peer Reviewed verified by ORBi

Lenzini, M. V., Ishihara, H., Dusart, J., Ogawara, H., Joris, B., Van Beeumen, J., Frère, J.-M., & Ghuysen, J.-M. (1988). Nucleotide sequence of the gene encoding the active-site serine β-lactamase from Streptomyces cacaoi. FEMS Microbiology Letters, 49 (3), 371-376. doi:10.1111/j.1574-6968.1988.tb02760.x
Peer Reviewed verified by ORBi

Frère, J.-M., Joris, B., Dideberg, O., Charlier, P., & Ghuysen, J.-M. (1988). Penicillin-recognizing enzymes. Biochemical Society Transactions, 16 (6), 934-938. doi:10.1042/bst0160934
Peer Reviewed verified by ORBi

Varetto, L., Frère, J.-M., & Ghuysen, J.-M. (10 December 1987). The importance of the negative charge of β-lactam compounds for the inactivation of the active-site serine DD-peptidase of Streptomyces R61. FEBS Letters, 225 (1-2), 218-222. doi:10.1016/0014-5793(87)81161-4
Peer Reviewed verified by ORBi

Lenzini, M. V., Nojima, S., Dusart, J., Ogawara, H., Dehottay, P., Frère, J.-M., & Ghuysen, J.-M. (October 1987). Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular β-lactamase from Streptomyces cacaoi. Journal of General Microbiology, 133 (10), 2915-2920.
Peer Reviewed verified by ORBi

Dehottay, P., Dusart, J., De Meester, F., Joris, B., Van Beeumen, J., Erpicum, T., Frère, J.-M., & Ghuysen, J.-M. (15 July 1987). Nucleotide sequence of the gene encoding the Streptomyces albus G β-lactamase precursor. European Journal of Biochemistry, 166 (2), 345-350. doi:10.1111/j.1432-1033.1987.tb13521.x
Peer Reviewed verified by ORBi

Varetto, L., Frère, J.-M., Nguyen-Distèche, M., Ghuysen, J.-M., & Houssier, C. (02 February 1987). The pH dependence of the active-site serine DD-peptidase of Streptomyces R61. European Journal of Biochemistry, 162 (3), 525-531. doi:10.1111/j.1432-1033.1987.tb10671.x
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Nguyen-Distèche, M., Bellefroid-Bourguignon, C., & Ghuysen, J.-M. (01 February 1987). Effects of thiol reagents on Streptomyces K15 DD-peptidase-catalysed reactions. Biochemical Journal, 241 (3), 893-897. doi:10.1042/bj2410893
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Ghuysen, J.-M., & Reginster, M. (01 January 1987). Eloge academique du professeur Maurice Welsch, membre titulaire et ancien président. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 142 (2-3), 185-191.

Joris, B., Jacques, P., Frère, J.-M., Ghuysen, J.-M., & Van Beeumen, J. (1987). Primary structure of the Streptomyces R61 extracellular DD-peptidase. 2. Amino acid sequence data. European Journal of Biochemistry, 162 (3), 519-524. doi:10.1111/j.1432-1033.1987.tb10670.x
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Demeester, F., Joris, B., Lenzini, M. V., Dehottay, P., Erpicium, T., Dusart, J., Klein, D., Ghuysen, J.-M., Frère, J.-M., & Vanbeeumen, J. (1987). The active sites of the β-lactamases of Streptomyces cacaoi and Streptomyces albus G. Biochemical Journal, 244 (2), 427-432. doi:10.1042/bj2440427
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Dideberg, O., Charlier, P., Wery, J.-P., Dehottay, P., Dusart, J., Erpicum, T., Frère, J.-M., & Ghuysen, J.-M. (1987). The crystal structure of the β-lactamase of Streptomyces albus G at 0.3 nm resolution. Biochemical Journal, 245 (3), 911-913. doi:10.1042/bj2450911
Peer Reviewed verified by ORBi

Duez, C., Fraipont, C., Joris, B., Dusart, J., Urdea, M. S., Martial, J., Frère, J.-M., & Ghuysen, J.-M. (1987). Primary structure of the Streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene. European Journal of Biochemistry, 162, 509-518. doi:10.1111/j.1432-1033.1987.tb10669.x
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1987). B-Lactam Antibiotics as Carbonyl Donors of the Active-Site Serine B-Lacta-Mases, DD-Peptidases and LL-Peptidases. Frontiers in Microbiology, 7-27.
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Nguyen-Distèche, M., Leyh-Bouille, M., Pirlot, S., Frère, J.-M., & Ghuysen, J.-M. (01 April 1986). Streptomyces K15 DD-peptidase-catalysed reactions with ester and amide carbonyl donors. Biochemical Journal, 235 (1), 167-176. doi:10.1042/bj2350167
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Leyh-Bouille, M., Nguyen-Distèche, M., Pirlot, S., Veithen, A., Bourguignon, C., & Ghuysen, J.-M. (01 April 1986). Streptomyces K15 DD-peptidase-catalysed reactions with suicide β-lactam carbonyl donors. Biochemical Journal, 235 (1), 177-182. doi:10.1042/bj2350177
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., & Coyette, J. (01 April 1986). Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes. Biochemical Journal, 235 (1), 159-165. doi:10.1042/bj2350159
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Kelly, J. A., Dideberg, O., Charlier, P., Wery, J.-P., Libert, M., Moews, P., Knox, J., Duez, C., Fraipont, C., Joris, B., Dusart, J., Frère, J.-M., & Ghuysen, J.-M. (21 March 1986). On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target. Science, 231, 1429-1431. doi:10.1126/science.3082007
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Dehottay, P., Dusart, J., Duez, C., Lenzini, M. V., Martial, J., Frère, J.-M., Ghuysen, J.-M., & Kieser, T. (1986). Cloning and amplified expression in Streptomyces lividans of a gene encoding extracellular β-lactamase from Streptomyces albus G. Gene, 42 (1), 31-36. doi:10.1016/0378-1119(86)90147-2
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Kelly, J. A., Knox, J. R., Moews, P. C., Hite, G. J., Bartolone, J. B., Zhao, H., Joris, B., Frère, J.-M., & Ghuysen, J.-M. (25 May 1985). 2.8-Å Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with β-lactams. Journal of Biological Chemistry, 260 (10), 6449-6458.
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Laurent, G., Durant, F., Frère, J.-M., Klein, D., & Ghuysen, J.-M. (15 March 1984). Des-, syn- and anti-oxyimino-Δ3-cephalosporins. Intrinsic reactivity and reaction with RTEM-2 serine β-lactamase and D-alanyl-D-alanine-cleaving serine and zinc-containing peptidases. Biochemical Journal, 218 (3), 933-937. doi:10.1042/bj2180933
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Dive, G., Peeters, D., Leroy, G., & Ghuysen, J.-M. (February 1984). Theoretical study of the C-N bond breakage catalyzed by the serine peptidases. Journal of Molecular Structure: Theochem, 16, 117-126. doi:10.1016/0166-1280(84)80046-9
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G., & Lamotte-Brasseur, J. (1984). Bacterial cell wall, DD-peptidase and β-lactam antibiotics. Scandinavian Journal of Infectious Diseases, 42, 17-37.
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Frère, J.-M., Klein, D., Kelly, J. A., & Ghuysen, J.-M. (1984). Interaction between monobactams and model D-alanyl-D-alanine-cleaving peptidases. FEMS Microbiology Letters, 21, 213-217. doi:10.1111/j.1574-6968.1984.tb00213.x
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Lamotte-Brasseur, J., Dive, G., & Ghuysen, J.-M. (1984). On the structural analogy between D-alanyl-D-alanine terminated peptides and β-lactam antibiotics. European Journal of Medicinal Chemistry, 4, 319-330.
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G., & Lamotte-Brasseur, J. (1984). Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics. Scandinavian Journal of Infectious Diseases, 42, 17-37.
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Charlier, P., Dideberg, O., Jamoulle, J.-C., Frère, J.-M., Ghuysen, J.-M., Dive, G., & Lamotte, J. (1984). Active-site-directed inactivators of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G. Biochemical Journal, 219 (3), 763-772. doi:10.1042/bj2190763
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Labischinski, H., Giesbrecht, P., Fischer, E., Barnickel, G., Bradaczek, H., Frère, J.-M., Houssier, C., Charlier, P., Dideberg, O., & Ghuysen, J.-M. (1984). Study of the Zn-containing DD-carboxypeptidase of Streptomyces albus G by small-angle X-ray scattering in solution. European Journal of Biochemistry, 138 (1), 83-87. doi:10.1111/j.1432-1033.1984.tb07884.x
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Joris, B., Van Beeumen, J., Casagrande, F., Gerday, C., Frère, J.-M., & Ghuysen, J.-M. (17 January 1983). The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G. European Journal of Biochemistry, 130 (1), 53-69. doi:10.1111/j.1432-1033.1983.tb07116.x
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Charlier, P., Dideberg, O., Dive, G., Ghuysen, J.-M., Lamotte-Brasseur, J., & Wery, J. P. (1983). Application de l'informatique dans l'étude des mecanismes enzymatiques a l'échelle moléculaire. Demain. Études et expansion.

Rousset, A., Nguyen-Distèche, M., Minck, R., & Ghuysen, J.-M. (01 December 1982). Penicillin-binding proteins and carboxypeptidase/transpeptidase activities in Proteus vulgaris P18 and its penicillin-induced stable L-forms. Journal of Bacteriology, 152 (3), 1042-1048.
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Kelly, J. A., Moews, P. C., Knox, J. R., Frère, J.-M., & Ghuysen, J.-M. (29 October 1982). Penicillin target enzyme and the antibiotic binding site. Science, 218 (4571), 479-481. doi:10.1126/science.7123246
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Nguyen-Distèche, M., Leyh-Bouille, M., & Ghuysen, J.-M. (01 October 1982). Isolation of the membrane-bound 26 000-Mr penicillin-binding protein of Streptomyces strain K15 in the form of a penicillin-sensitive D-alanyl-D-alanine-cleaving transpeptidase. Biochemical Journal, 207 (1), 109-115. doi:10.1042/bj2070109
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Frère, J.-M., Kelly, J. A., Klein, D., Ghuysen, J.-M., Claes, P., & Vanderhaeghe, H. (01 April 1982). Δ2- and Δ3-Cephalosporins, penicillinate, and 6-unsubstituted penems. Intrinsic reactivity and interaction with β-lactamases and D-alanyl-D-alanine-cleaving serine peptidases. Biochemical Journal, 203 (1), 223-234. doi:10.1042/bj2030223
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Duez, C., Frère, J.-M., Ghuysen, J.-M., Van Beeumen, J., Delcambe, L., & Dierickx, L. (1982). Purification and properties of the exocellular β-lactamase of Actinomadura strain R39. Biochimica et Biophysica Acta - General Subjects, 700, 24-32. doi:10.1016/0167-4838(82)90287-4
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Dideberg, O., Charlier, P., Dive, G., Joris, B., Frère, J.-M., & Ghuysen, J.-M. (1982). Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution. Nature, 299 (5882), 469-470. doi:10.1038/299469a0
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De Coen, J.-L., Lamotte, J., Ghuysen, J.-M., Frère, J.-M., & Perkins, H. R. (01 December 1981). Conformational analysis of peptide substrates and inhibitors of the Zn2+ G and serine R61 D-alanyl-D-alanine peptidases. European Journal of Biochemistry, 121 (1), 221-232. doi:10.1111/j.1432-1033.1981.tb06452.x
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Perkins, H. R., Frère, J.-M., & Ghuysen, J.-M. (01 December 1981). Synthetic peptide inhibitors of transpeptidation by the exocellular DD-carboxypeptidase-transpeptidase from Actinomadura R39. FEBS Letters, 123 (1), 75-78. doi:10.1016/0014-5793(81)80023-3
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Kelly, J. A., Frère, J.-M., Klein, D., & Ghuysen, J.-M. (01 October 1981). Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases. Biochemical Journal, 199 (1), 129-136. doi:10.1042/bj1990129
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Leyh-Bouille, M., Nguyen-Distèche, M., & Ghuysen, J.-M. (01 April 1981). On the DD-carboxypeptidase enzyme system of Streptomyces strain K15. European Journal of Biochemistry, 115 (3), 579-584. doi:10.1111/j.1432-1033.1981.tb06242.x
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Janczura, E., Leyh-Bouille, M., Cocito, C., & Ghuysen, J.-M. (01 February 1981). Primary structure of the wall peptidoglycan of leprosy-derived corynebacteria. Journal of Bacteriology, 145 (2), 775-779.
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Duez, C., Frère, J.-M., Ghuysen, J.-M., Van Beeumen, J., & Vandekerckhove, J. (1981). Studies on the primary structures of the exocellular D-Alanyl-D-Alanine peptidases of Streptomyces strain R61 and Actinomadura strain R39. Biochimica et Biophysica Acta - General Subjects, 671, 109-116. doi:10.1016/0005-2795(81)90123-9
Peer Reviewed verified by ORBi

Dusart, J., Reynolds, P. E., & Ghuysen, J.-M. (1981). Penicillin binding proteins and model transpeptidase activity of the plasma membranes of Streptomyces strains R61 and rimosus. FEMS Microbiology Letters, 12 (3), 299-303. doi:10.1111/j.1574-6968.1981.tb07662.x

Duez, C., Joris, B., Frère, J.-M., Ghuysen, J.-M., & Van Beeumen, J. (1981). The penicillin-binding site in the exocellular DD-carboxypeptidase-transpeptidase of Actinomadura R39. Biochemical Journal, 193, 83-86. doi:10.1042/bj1930083
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Kelly, J., Frère, J.-M., Duez, C., & Ghuysen, J.-M. (1981). Interactions between non-classical β-lactam compounds and the β-lactamases of Actinomadura R39 and Streptomyces albus G. Biochemical Journal, 199, 137-143. doi:10.1042/bj1990137
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Duez, C., Frère, J.-M., Klein, D., Noël, M., Ghuysen, J.-M., Delcambe, L., & Dierickx, L. (1981). The exocellular β-lactamase of Streptomyces albus G. Purification, properties and comparison with the exocellular DD-carboxypeptidase. Biochemical Journal, 193 (1), 75-82. doi:10.1042/bj1930075
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Frère, J.-M., Klein, D., & Ghuysen, J.-M. (01 October 1980). Enzymatic method for rapid and sensitive determination of β-lactam antibiotics. Antimicrobial Agents and Chemotherapy, 18 (4), 506-510. doi:10.1128/AAC.18.4.506
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Coyette, J., Ghuysen, J.-M., & Fontana, R. (01 September 1980). The penicillin-binding proteins in Streptococcus faecalis ATCC 9790. European Journal of Biochemistry, 110 (2), 445-456. doi:10.1111/j.1432-1033.1980.tb04886.x
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Dideberg, O., Joris, B., Frère, J.-M., Ghuysen, J.-M., Weber, G., Robaye, R., Delbrouck, J. M., & Roelandts, I. (11 August 1980). The exocellular DD-carboxypeptidase of Streptomyces albus G: A metallo (Zn2+) enzyme. FEBS Letters, 117 (1-2), 215-218. doi:10.1016/0014-5793(80)80948-3
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Perkins, H.-R., & Nieto, M. (16 May 1980). The active centres in penicillin-sensitive enzymes. Philosophical Transactions. Biological Sciences, 289 (1036), 285-301. doi:10.1098/rstb.1980.0046
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Dusart, J., Leyh-Bouille, M., Nguyen-Distèche, M., Ghuysen, J.-M., & Reynolds, P.-E. (01 February 1980). Penicillin-binding proteins in the membranes of Streptomyces sp. Archives Internationales de Physiologie et de Biochimie, 88 (1), 27-B29.
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Dideberg, O., Charlier, P., Dupont, L., Vermeire, M., Frère, J.-M., & Ghuysen, J.-M. (1980). The 4.5 Å resolution structure analysis of the exocellular DD-carboxypeptidase of Streptomyces albus G. FEBS Letters, 117 (1), 212-214. doi:10.1016/0014-5793(80)80947-1
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Dideberg, O., Frère, J.-M., & Ghuysen, J.-M. (25 April 1979). Crystallographic data for the DD-carboxypeptidase-endopeptidase of low penicillin sensitivity excreted by Streptomyces albus g. Journal of Molecular Biology, 129 (4), 677-679. doi:10.1016/0022-2836(79)90477-7
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Marquet, A., Frère, J.-M., Ghuysen, J.-M., & Loffet, A. (01 March 1979). Effects of nucleophiles on the breakdown of the benzylpenicilloyl-enzyme complex EI formed between benzylpenicillin and the exocellular DD-carboxypeptidase--transpeptiase of Streptomyces strain R61. Biochemical Journal, 177 (3), 909-916. doi:10.1042/bj1770909
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Degelaen, J., Feeney, J., Roberts, G. C. K., Burgen, A. S. V., Frère, J.-M., & Ghuysen, J.-M. (01 February 1979). NMR evidence for the structure of the complex between penicillin and the DD-carboxypeptidase of streptomyces R61. FEBS Letters, 98 (1), 53-56. doi:10.1016/0014-5793(79)80150-7
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Coyette, J., Dusart, J., & Nguyen-Distèche, M. (01 January 1979). Use of model enzymes in the determination of the mode of action of penicillins and ∆3-cephalosporins. Annual Review of Biochemistry, 48, 73-101. doi:10.1146/annurev.bi.48.070179.000445
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Coyette, J., Dusart, J., Nguyen-Distèche, M., Marquet, A., & Duez, C. (1979). Interaction between penicillin and its enzyme target. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 2, 287-300.
Peer Reviewed verified by ORBi

Coyette, J., Ghuysen, J.-M., & Fontana, R. (17 July 1978). Solubilization and isolation of the membrane-bound DD-carboxypeptidase of Streptococcus faecalis ATCC9790. Properties of the purified enzyme. European Journal of Biochemistry, 88 (1), 297-305. doi:10.1111/j.1432-1033.1978.tb12450.x
Peer Reviewed verified by ORBi

Adriaens, P., Meesschaert, B., Frère, J.-M., Vanderhaeghe, H., Degelaen, J., Ghuysen, J.-M., & Eyssen, H. (25 April 1978). Stability of D-5,5-dimethyl-delta2-thiazoline-4-carboxylic acid in relation to its possible occurrence as a degradation product of penicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and the membrane-bound dd-carboxypeptidase from Bacillus stearothermophilus. Journal of Biological Chemistry, 253 (10), 3660-3665.
Peer Reviewed verified by ORBi

Schilf, W., Frere, P., Frère, J.-M., Martin, H.-H., Ghuysen, J.-M., Adriaens, P., & Meesschaert, B. (17 April 1978). Interaction between penicillin and the DD-carboxypeptidase of the unstable L-form of Proteus mirabilis strain 19. European Journal of Biochemistry, 85 (2), 325-330. doi:10.1111/j.1432-1033.1978.tb12242.x
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Frère, J.-M., Ghuysen, J.-M., & De Graeve, J. (01 April 1978). Fragmentation of penicillin catalysed by the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces strain r61. Isotopic study of hydrogen fixation on carbon 6. FEBS Letters, 88 (1), 147-150. doi:10.1016/0014-5793(78)80628-0
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Fossati, P., Saint-Ghislain, M., Sicard, P. J., Frère, J.-M., Dusart, J., Klein, D., & Ghuysen, J.-M. (April 1978). Large Scale Preparation of Purified Exocellular DD-carboxypeptidase-Transpeptidase of Streptomyces Strain R61. Biotechnology and Bioengineering, 20, 577-587. doi:10.1002/bit.260200409
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Duez, C., Frère, J.-M., Geurts, F., Ghuysen, J.-M., Dierickx, L., & Delcambe, L. (1978). The exocellular DD-carboxypeptidase-endopeptidase from Streptomyces albus Gl. Purification and chemical properties. Biochemical Journal, 175 (3), 793-800.
Peer Reviewed verified by ORBi

Frère, J.-M., Geurts, F., & Ghuysen, J.-M. (1978). The exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G. Interaction with beta-lactam antibiotics. Biochemical Journal, 175 (3), 801-805. doi:10.1042/bj1750801
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Dusart, J., Leyh-Bouille, M., & Ghuysen, J.-M. (15 November 1977). The peptidoglycan crosslinking enzyme system in Streptomyces strains R61, K15 and rimosus : Kinetic Coefficients Involved in the Interactions of the Membrane-Bound Transpeptidase with Peptide Substrates and β-Lactam Antibiotics. European Journal of Biochemistry, 81 (1), 33-44. doi:10.1111/j.1432-1033.1977.tb11924.x
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Nguyen-Distèche, M., Frère, J.-M., Dusart, J., Leyh-Bouille, M., Ghuysen, J.-M., Pollock, J. J., & Iacono, V. J. (15 November 1977). The peptidoglycan crosslinking enzyme system in Streptomyces R61, K15 and rimosus. Immunological studies. European Journal of Biochemistry, 81 (1), 29-32. doi:10.1111/j.1432-1033.1977.tb11923.x
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Ghuysen, J.-M. (01 July 1977). The concept of the penicillin target from 1965 until today. The thirteenth marjory stephenson memorial lecture. Journal of General Microbiology, 101 (1), 13-33. doi:10.1099/00221287-101-1-13
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Coyette, J., Ghuysen, J.-M., & Perkins, H. R. (02 May 1977). The exchange reaction of peptides R-D-alanyl-D-alanine with D-[14C]alanine to R-D-alanyl-D-[14C]alanine and D-alanine, catalysed by the membranes of Streptococcus faecalis ATCC 9790. European Journal of Biochemistry, 75 (1), 225-229. doi:10.1111/j.1432-1033.1977.tb11521.x
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Coyette, J., Ghuysen, J.-M., Binot, F., Adriaens, P., Meesschaert, B., & Vanderhaeghe, H. (02 May 1977). Interactions between beta-lactam antibiotics and isolated membranes of Streptococcus faecalis ATCC 9790. European Journal of Biochemistry, 75 (1), 231-239. doi:10.1111/j.1432-1033.1977.tb11522.x
Peer Reviewed verified by ORBi

Tinelli, R., & Ghuysen, J.-M. (01 January 1977). Biosynthèse de la paroi bactérienne. Bulletin de l'Association des Anciens Elèves de l’Institut Pasteur [=Bulletin de l'AAEIP], 71, 4-14.

Ghuysen, J.-M. (1977). Le récepteur de la penicilline chez les bactéries. Bulletin de l'Académie Royale de Médecine de Belgique, 132 (1), 101-108.
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Ghuysen, J.-M. (1977). récepteur de pénicilline dans des bactéries. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 132 (1bis), 101-109.
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Ghuysen, J.-M. (1977). Penicillin-Sensitive Enzymes of Peptidoglycan Metabolism. Critical Reviews in Microbiology, 195-201.
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Leyh-Bouille, M., Dusart, J., Nguyen Van, M., Ghuysen, J.-M., Reynolds, P. E., & Perkins, H. R. (1977). The peptidoglycan crosslinking enzyme system in Streptomyces strains R61, K15 and rimosus. Exocellular, lysozyme-releasable and membrane-bound enzymes. European Journal of Biochemistry, 81 (1), 19-28. doi:10.1111/j.1432-1033.1977.tb11922.x
Peer Reviewed verified by ORBi

Frère, J.-M., Duez, C., Ghuysen, J.-M., & Vandekerkhove, J. (November 1976). Occurrence of a serine residue in the penicillin-binding site of the exocellular DD-carboxy-peptidase-transpeptidase from streptomyces R61. FEBS Letters, 70 (1), 257-260. doi:10.1016/0014-5793(76)80770-3
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Frère, J.-M., Ghuysen, J.-M., Vanderhaeghe, H., Adriaens, P., Degelaen, J., & De Graeve, J. (01 April 1976). Fate of thiazolidine ring during fragmentation of penicillin by exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. Nature, 260 (5550), 451-454. doi:10.1038/260451a0
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Frère, J.-M., Ghuysen, J.-M., Zeiger, A., & Perkins, H. R. (15 March 1976). The direction of peptide trimer synthesis from the donor-acceptor substrate Nalpha-(acetyl)-Nepsilon-(glycyl)-L-lysyl-D-alanyl-D-alanine by the exocellular dd-carboxypeptidase-transpeptidase of Streptomyces R61. FEBS Letters, 63 (1), 112-116.
Peer Reviewed verified by ORBi

Arminjon, F., Guinand, M., Michel, G., Coyette, J., & Ghuysen, J.-M. (01 January 1976). Préparation enzymatique de peptides du type (L)meso-diaminopimélyl(L)-D-Ala[14C]: par réactions d'échange entre les peptides correspondants non radioactifs et la D-alanine [14C]. Biochimie, 58 (10), 1167-1172. doi:10.1016/S0300-9084(76)80115-0
Peer Reviewed verified by ORBi

Fuad, N., Frère, J.-M., Ghuysen, J.-M., Duez, C., & Iwatsubo, M. (1976). Mode of interaction between β-lactam antibiotics and the exocellular DD-carboxypeptidase--transpeptidase from Streptomyces R39. Biochemical Journal, 155 (3), 623-629. doi:10.1042/bj1550623
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Frère, J.-M., Adriaens, P., Degelaen, J., Vanderhaeghe, H., & Ghuysen, J.-M. (01 December 1975). Degradation of benzylpenicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R 61. Archives Internationales de Physiologie et de Biochimie, 83 (5), 905-907. doi:10.3109/13813457509069522
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., Degelaen, J., Loffet, A., & Perkins, H. R. (13 November 1975). Fragmentation of benzylpenicillin after interaction with the exocellular DD-carboxypeptidase-transpeptidases of Streptomyces R61 and R39. Nature, 258 (5531), 168-170. doi:10.1038/258168a0
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., & Perkins, H. R. (15 September 1975). Interaction between the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61, substrate and beta-lactam antibiotics. A choice of models. European Journal of Biochemistry, 57 (2), 353-359. doi:10.1111/j.1432-1033.1975.tb02308.x
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., & Iwatsubo, M. (15 September 1975). Kinetics of interaction between the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and beta-lactam antibiotics. A choice of models. European Journal of Biochemistry, 57 (2), 343-351. doi:10.1111/j.1432-1033.1975.tb02307.x
Peer Reviewed verified by ORBi

Dusart, J., Marquet, A., Ghuysen, J.-M., & Perkins, H. R. (01 August 1975). The catalytic activity and penicillin sensitivity in the liquid and frozen states of membrane-bound and detergent-solubilised transpeptidase of Streptomyces R61. European Journal of Biochemistry, 56 (1), 57-65. doi:10.1111/j.1432-1033.1975.tb02206.x
Peer Reviewed verified by ORBi

Zeiger, A. R., Frère, J.-M., Ghuysen, J.-M., & Perkins, H. R. (01 April 1975). A donor-acceptor substrate of the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61. FEBS Letters, 52 (2), 221-225. doi:10.1016/0014-5793(75)80810-6
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1975). Paroi bactérienne, membrane cytoplasmique et pénicilline. Microbia, A (2).

Johnson, K., Duez, C., Frère, J.-M., & Ghuysen, J.-M. (1975). Beta-lactamases (Actinomycetes species). Methods in Enzymology, XLIII, 687-698. doi:10.1016/0076-6879(75)43134-2
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Dusart, J., Nguyen-Distèche, M., Coyette, J., Perkins, H., Nieto, M., & Marquet, A. (1975). Bacterial transpeptidases and penicillin. Bulletin de l'Institut Pasteur, 73 (1), 101-140.
Peer reviewed

Frère, J.-M., Leyh-Bouille, M., Ghuysen, J.-M., & Perkins, H. R. (16 December 1974). Interaction between beta-lactam antibiotics and exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. European Journal of Biochemistry, 50 (1), 203-214. doi:10.1111/j.1432-1033.1974.tb03889.x
Peer Reviewed verified by ORBi

Frère, J.-M., Moreno, R., & Ghuysen, J.-M. (01 October 1974). Molecular weight, amino acid composition and physicochemical properties of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39. Biochemical Journal, 143 (1), 233-240. doi:10.1042/bj1430233
Peer Reviewed verified by ORBi

Wietzerbin, J., Das, B. C., Petit, J.-F., Lederer, E., Leyh-Bouille, M., & Ghuysen, J.-M. (13 August 1974). Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid interpeptide linkages in the peptidoglycan of Mycobacteria. Biochemistry, 13 (17), 3471-3476. doi:10.1021/bi00714a008
Peer Reviewed verified by ORBi

Marquet, A., Dusart, J., Ghuysen, J.-M., & Perkins, H.-R. (01 August 1974). Membrane-bound transpeptidase and penicillin binding sites in Streptomyces strain R61. European Journal of Biochemistry, 46 (3), 515-523. doi:10.1111/j.1432-1033.1974.tb03645.x
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Reynolds, P. E., Perkins, H. R., Frère, J.-M., & Moreno, R. (04 June 1974). Effects of donor and acceptor peptides on concomitant hydrolysis and transfer reactions catalyzed by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R39. Biochemistry, 13 (12), 2539-2547. doi:10.1021/bi00709a010
Peer Reviewed verified by ORBi

Coyette, J., Perkins, H. R., Polacheck, I., Shockman, G. D., & Ghuysen, J.-M. (15 May 1974). Membrane-bound DD-carboxypeptidase and LD-transpeptidase of Streptococcus faecalis ATCC 9790. European Journal of Biochemistry, 44 (2), 459-468. doi:10.1111/j.1432-1033.1974.tb03504.x
Peer Reviewed verified by ORBi

Pollock, J. J., Nguyen-Distèche, M., Ghuysen, J.-M., Linder, R., & Salton, M. R. (10 May 1974). The DD-carboxypeptidase-transpeptidase system in Escherichia coli mutant strain. Annals of the New York Academy of Sciences, 235, 225-235. doi:10.1111/j.1749-6632.1974.tb43268.x
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Marquet, A., Perkins, H. R., & Nieto, M. (10 May 1974). The penicillin receptor in Streptomyces. Annals of the New York Academy of Sciences, 235, 236-268. doi:10.1111/j.1749-6632.1974.tb43269.x
Peer Reviewed verified by ORBi

Nguyen-Distèche, M., Pollock, J. J., Ghuysen, J.-M., Puig, J., Reynolds, P., Perkins, H.-R., Coyette, J., & Salton, M.-R.-J. (01 February 1974). Sensitivity to ampicillin and cephalothin of enzymes involved in wall peptide crosslinking in Escherichia coli K12, strain 44. European Journal of Biochemistry, 41 (3), 457-463. doi:10.1111/j.1432-1033.1974.tb03287.x
Peer Reviewed verified by ORBi

Nguyen-Distèche, M., Ghuysen, J.-M., Pollock, J. J., Reynolds, P., Perkins, H. R., Coyette, J., & Salton, M. R. (01 February 1974). Enzymes involved in wall peptide crosslinking in Escherichia coli K12, strain 44. European Journal of Biochemistry, 41 (3), 447-455. doi:10.1111/j.1432-1033.1974.tb03286.x
Peer Reviewed verified by ORBi

Pollock, J. J., Nguyen-Distèche, M., Ghuysen, J.-M., Coyette, J., Linder, R., Salton, M. R., Kim, K. S., Perkins, H.-R., & Reynolds, P. (1974). Fractionation of the DD-carboxypeptidase-transpeptidase activities solubilized from membranes of Escherichia coli K12, strain 44. European Journal of Biochemistry, 41 (3), 439-446. doi:10.1111/j.1432-1033.1974.tb03285.x
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1974). Substrate Requirements of Glycosidases for Lytic Activity on Bacterial Walls. Lysozyme, 185-193.

Ghuysen, J.-M., Leyh-Bouille, M., Frère, J.-M., Dusart, J., Coyette, J., Nguyen-Distèche, M., & Duez, C. (1974). Comment la Pénicilline tue les bactéries. Annales de Microbiologie, 125 B (2), 209-210.
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., Reynolds, P. E., & Moreno, R. (1974). Binding of beta-lactam antibiotics to the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39. Biochemical Journal, 143 (1), 241-249. doi:10.1042/bj1430241
Peer Reviewed verified by ORBi

Nieto, M., Perkins, H. R., Frère, J.-M., & Ghuysen, J.-M. (01 November 1973). Fluorescence and circular dichroism studies on the Streptomyces R61 DD-carboxypeptidase-transpeptidase. Penicillin binding by the enzyme. Biochemical Journal, 135 (3), 493-505. doi:10.1042/bj1350493
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., Perkins, H. R., & Nieto, M. (01 November 1973). Molecular weight and amino acid composition of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. Biochemical Journal, 135 (3), 463-468. doi:10.1042/bj1350463
Peer Reviewed verified by ORBi

Frère, J.-M., Ghuysen, J.-M., Perkins, H. R., & Nieto, M. (01 November 1973). Kinetics of concomitant transfer and hydrolysis reactions catalysed by the exocellular DD-carboxypeptidase-transpeptidase of streptomyces R61. Biochemical Journal, 135 (3), 483-492. doi:10.1042/bj1350483
Peer Reviewed verified by ORBi

Martin, J.-P., Fleck, J., Mock, M., & Ghuysen, J.-M. (05 October 1973). The wall peptidoglycans of Neisseria perflava, Moraxella glucidolytica, Pseudomonas alcaligenes and Proteus vulgaris strain P18. European Journal of Biochemistry, 38 (2), 301-306. doi:10.1111/j.1432-1033.1973.tb03062.x
Peer Reviewed verified by ORBi

Perkins, H. R., Nieto, M., Frère, J.-M., Leyh-Bouille, M., & Ghuysen, J.-M. (01 April 1973). Streptomyces DD-carboxypeptidases as transpeptidases. The specificity for amino compounds acting as carboxyl acceptors. Biochemical Journal, 131 (4), 707-718. doi:10.1042/bj1310707
Peer Reviewed verified by ORBi

Dusart, J., Marquet, A., Ghuysen, J.-M., Frère, J.-M., Moreno, R., Leyh-Bouille, M., Johnson, K., Lucchi, C., Perkins, H. R., & Nieto, M. (02 February 1973). DD-carboxypeptidase-transpeptidase and killing site of β-lactam antibiotics in Streptomyces strains R39, R61, and K11. Antimicrobial Agents and Chemotherapy, 3 (2), 181-187. doi:10.1128/AAC.3.2.181
Peer Reviewed verified by ORBi

Johnson, K., Dusart, J., Campbell, J. N., & Ghuysen, J.-M. (01 February 1973). Exocellular β-lactamases of Streptomyces albus G and strains R39 and K11. Antimicrobial Agents and Chemotherapy, 3 (2), 289-298. doi:10.1128/AAC.3.2.289
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Leyh-Bouille, M., Campbell, J. N., Frère, J.-M., Duez, C., Nieto, M., & Perkins, H. R. (1973). Structure of the wall peptidoglycan of streptomyces R39 and the specificity profile of its exocellular DD-carboxypeptidase-transpeptidase for peptide acceptors. Biochemistry, 12 (7), 1243-1251. doi:10.1021/bi00731a001
Peer Reviewed verified by ORBi

Nieto, M., Perkins, H. R., Leyh-Bouille, M., Frère, J.-M., & Ghuysen, J.-M. (01 January 1973). Peptide inhibitors of Streptomyces DD-carboxypeptidases. Biochemical Journal, 131 (1), 163-171. doi:10.1042/bj1310163
Peer Reviewed verified by ORBi

Vacheron, M.-J., Guinand, M., Michel, G., & Ghuysen, J.-M. (18 August 1972). Structural investigations on cell walls of Nocardia sp. The wall lipid and peptidoglycan moieties of Nocardia kirovani. European Journal of Biochemistry, 29 (1), 156-166. doi:10.1111/j.1432-1033.1972.tb01970.x
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Nakel, M., Frère, J.-M., Johnson, K., Ghuysen, J.-M., Nieto, M., & Perkins, H. R. (28 March 1972). Penicillin-sensitive DD-carboxypeptidases from Streptomyces strains R39 and K11. Biochemistry, 11 (7), 1290-1298. doi:10.1021/bi00757a027
Peer Reviewed verified by ORBi

Pollock, J. J., Ghuysen, J.-M., Linder, R., Salton, M. R. J., Perkins, H. R., Nieto, M., Leyh-Bouille, M., Frère, J.-M., & Johnson, K. (01 March 1972). Transpeptidase activity of Streptomyces D-alanyl-D carboxypeptidases. Proceedings of the National Academy of Sciences of the United States of America, 69 (3), 662-666. doi:10.1073/pnas.69.3.662
Peer Reviewed verified by ORBi

Nakel, M., Ghuysen, J.-M., & Kandler, O. (25 May 1971). Wall peptidoglycan in Aerococcus viridans strains 201 Evans and ATCC 11563 and in Gaffkya homari strain ATCC 10400. Biochemistry, 10 (11), 2170-2175. doi:10.1021/bi00787a033
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Coyette, J., Ghuysen, J.-M., Idczak, J., Perkins, H. R., & Nieto, M. (25 May 1971). Penicillin-sensitive DD-carboxypeptidase from Streptomyces strain R 61. Biochemistry, 10 (11), 2163-2170. doi:10.1021/bi00787a032
Peer Reviewed verified by ORBi

Wheat, R.-W., & Ghuysen, J.-M. (March 1971). Occurrence of glucomuramic acid in gram-positive bacteria. Journal of Bacteriology, 105 (3), 1219-1221.
Peer Reviewed verified by ORBi

Fleck, J., Mock, M., Minck, R., & Ghuysen, J.-M. (1971). The cell envelope in Proteus vulgaris P 18 : Isolation and characterization of the peptidoglycan component. Biochimica et Biophysica Acta. Biomembranes, 223 (3), 489-503. doi:10.1016/0005-2736(71)90149-0
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Ghuysen, J.-M., Bonaly, R., Nieto, M., Perkins, H. R., Schleifer, K. H., & Kandler, O. (21 July 1970). Substrate requirements of the Streptomyces albus G DD carboxypeptidase. Biochemistry, 9 (15), 2961-2970. doi:10.1021/bi00817a005
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Ghuysen, J.-M., Nieto, M., Perkins, H. R., Schleifer, K. H., & Kandler, O. (21 July 1970). On the Streptomyces albus G DD carboxypeptidase mechanism of action of penicillin, vancomycin, and ristocetin. Biochemistry, 9 (15), 2971-2975. doi:10.1021/bi00817a006
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Bonaly, R., Ghuysen, J.-M., Tinelli, R., & Tipper, D. (21 July 1970). LL-diaminopimelic acid containing peptidoglycans in walls of Streptomyces sp. and of Clostridium perfringens (type A). Biochemistry, 9 (15), 2944-2952. doi:10.1021/bi00817a002
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Leyh-Bouille, M., Bonaly, R., Nieto, M., Perkins, H. R., Schleifer, K. H., & Kandler, O. (21 July 1970). Isolation of DD carboxypeptidase from Streptomyces albus G culture filtrates. Biochemistry, 9 (15), 2955-2961. doi:10.1021/bi00817a004
Peer Reviewed verified by ORBi

Coyette, J., & Ghuysen, J.-M. (21 July 1970). Wall autolysin of Lactobacillus acidophilus strain 63 AM gasser. Biochemistry, 9 (15), 2952-2955. doi:10.1021/bi00817a003
Peer Reviewed verified by ORBi

Coyette, J., & Ghuysen, J.-M. (21 July 1970). Structure of the walls of Lactobacillus acidophilus strain 63 AM Gasser. Biochemistry, 9 (15), 2935-2943. doi:10.1021/bi00817a001
Peer Reviewed verified by ORBi

Tinelli, R., Shilo, M., Laurent, M., Ghuysen, J.-M., & Prévot, A.-R. (Other coll.). (25 May 1970). De la présence d'un glycopeptide dans la paroi de Bdello-vibrio vacteriovirus. Comptes Rendus de l'Académie des Sciences. Série III. Sciences de la Vie, 270, 2600-2602.
Peer Reviewed verified by ORBi

Azuma, I., Thomas, D. W., Adam, A., Ghuysen, J.-M., Bonaly, R., Petit, J.-F., & Lederer, E. (1970). Occurrence of N-glycolylmuramic acid in bacterial cell walls: a preliminary survey. Biochimica et Biophysica Acta - General Subjects, 208 (3), 444-451. doi:10.1016/0304-4165(70)90217-5
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Leyh-Bouille, M. (1970). Biochemistry of the Bacterial Wall Peptidoglycan in Relation to the Membrane. FEBS Symposium, 20, 59-69.

Ghuysen, J.-M., Leyh-Bouille, M., & Salton, M. R. J. (01 August 1969). The primary structure of bacterial wall peptidoglycans. Journal of General Microbiology, 57 (3).
Peer Reviewed verified by ORBi

Petit, J. F., Adam, A., Wietzerbin-Falszpan, J., Lederer, E., & Ghuysen, J.-M. (22 May 1969). Chemical structure of the cell wall of Mycobacterium smegmatis. I. Isolation and partial characterization of the peptidoglycan. Biochemical and Biophysical Research Communications, 35 (4), 478-485. doi:10.1016/0006-291x(69)90371-4
Peer reviewed

Guinand, M., Ghuysen, J.-M., Schleifer, K. H., & Kandler, O. (01 January 1969). The peptidoglycan in walls of Butyribacterium rettgeri. Biochemistry, 8 (1), 200-207. doi:10.1021/bi00829a029
Peer Reviewed verified by ORBi

Van Heijenoort, J., Elbaz, L., Dezelee, P., Petit, J.-F., Bricas, E., & Ghuysen, J.-M. (01 January 1969). Structure of the meso-diaminopimelic acid containing peptidoglycans in Escherichia coli B and Bacillus megaterium KM. Biochemistry, 8 (1), 207-213. doi:10.1021/bi00829a030
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Dierickx, L., Coyette, J., Leyh-Bouille, M., Guinand, M., & Campbell, J.-N. (01 January 1969). An improved technique for the preparation of Streptomyces peptidases and N-acetylmuramyl-l-alanine amidase active on bacterial wall peptidoglycans. Biochemistry, 8 (1), 213-222. doi:10.1021/bi00829a031
Peer Reviewed verified by ORBi

Campbell, J. N., Leyh-Bouille, M., & Ghuysen, J.-M. (01 January 1969). Characterization of the Micrococcus lysodeikticus type of peptidoglycan in walls of other Micrococcaceae. Biochemistry, 8 (1), 193-200. doi:10.1021/bi00829a028
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (01 December 1968). Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism. Bacteriological Reviews, 32 (4 Pt 2), 425-464. doi:10.1128/mmbr.32.4_pt_2.425-464.1968
Peer Reviewed verified by ORBi

Coyette, J., & Ghuysen, J.-M. (01 June 1968). Structure of the cell wall of Staphylococcus aureus, strain Copenhagen. IX. Teichoic acid and phage adsorption. Biochemistry, 7 (6), 2385-2389. doi:10.1021/bi00846a048
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Bricas, E., Lache, M., & Leyh-Bouille, M. (01 April 1968). Structure of the Cell Walls of Micrococcus lysodeikticus. III. Isolation of a New Peptide Dimer, Nα-[L-Alanyl-γ-(α-D-glutamyl-glycine )]-L-lysyl-D-alanyl-Nα- [L-alanyl-γ-(α-D-glutamyl-glycine)]-L-lysyl-D-alanine. Biochemistry, 7 (4), 1450-1460. doi:10.1021/bi00844a030
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1968). Bacterial cell walls. New Comprehensive Biochemistry, 26A, 53-104.
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Munoz, E., Leyh-Bouille, M., Petit, J., & Heymann, H. (1968). Structure and synthesis of the peptide subunits of the cell walls of three gram-positive bacteria. Colloques Internationaux du Centre National de la Recherche Scientifique, 286-292.
Peer reviewed

Ghuysen, J.-M. (1968). Structure and biosynthesis of the bacterial wall peptidoglycan. Colloques Internationaux du Centre National de la Recherche Scientifique, 175, 283-292.
Peer reviewed

Munoz, E., Ghuysen, J.-M., & Heymann, H. (01 December 1967). Cell walls of Streptococcus pyogenes, type 14. C polysaccharide-peptidoglycan and G polysaccharide-peptidoglycan complexes. Biochemistry, 6 (12), 3659-2670. doi:10.1021/bi00864a007
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Bricas, E., Leyh-Bouille, M., Lache, M., & Shockman, G. D. (01 August 1967). The peptide N alpha-(L-alanyl-D-isoglutaminyl)-N epsilon-(D-isoasparaginyl)-L-lysyl-D-alanine and the disaccharide N-acetylglucosaminyl-beta-1,4-N-acetylmuramic acid in cell wall peptidoglycan of Streptococcus faecalis strain ATCC 9790. Biochemistry, 6 (8), 2607-2619. doi:10.1021/bi00860a044
Peer Reviewed verified by ORBi

Bricas, E., Ghuysen, J.-M., & Dezelee, P. (01 August 1967). The Cell Wall Peptidoglycan of Bacillus megaterium KM. I. Studies on the Stereochemistry of α,α'-Diaminopimelic Acid. Biochemistry, 6 (8), 2598-2607. doi:10.1021/bi00860a043
Peer Reviewed verified by ORBi

Strominger, J. L., & Ghuysen, J.-M. (14 April 1967). Mechanisms of enzymatic bacteriaolysis. Cell walls of bacteri are solubilized by action of either specific carbohydrases or specific peptidases. Science, 156 (772), 213-221. doi:10.1126/science.156.3772.213
Peer Reviewed verified by ORBi

Tipper, D. J., Katz, W., Strominger, J. L., & Ghuysen, J.-M. (01 March 1967). Substituents on the alpha-carboxyl group of D-glutamic acid in the peptidoglycan of several bacterial cell walls. Biochemistry, 6 (3), 921-929. doi:10.1021/bi00855a036
Peer Reviewed verified by ORBi

Munoz, E., Ghuysen, J.-M., Leyh-Bouille, M., Petit, J.-F., & Tinelli, R. (October 1966). Structural variations in bacterial cell wall peptidoglycans studied with Streptomyces F1 endo-N-acetylmuramidase. Biochemistry, 5 (10), 3091–3098. doi:10.1021/bi00874a002
Peer Reviewed verified by ORBi

Leyh-Bouille, M., Ghuysen, J.-M., Tipper, D. J., & Stominger, J. L. (01 October 1966). Structure of the cell wall of Micrococcus lysodeikticus. I. Study of the structure of the glycan. Biochemistry, 5 (10), 3079-3090. doi:10.1021/bi00874a001
Peer Reviewed verified by ORBi

Petit, J.-F., Munoz, E., & Ghuysen, J.-M. (01 August 1966). Peptide cross-links in bacterial cell wall peptidoglycans studied with specific endopeptidases from Streptomyces albus G. Biochemistry, 5 (8), 2764-2776. doi:10.1021/bi00872a037
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Munoz, E., Leyh-Bouille, M., Petit, J.-F., Heymann, H., Bricas, E., & Lefrancier, P. (1966). Peptide subunit. N(super x)-(L-alanyl-D-isoglutaminyl)L-lysyl-D-alanine in cell wall peptidoglycans of Staphylococcus aureus strain Copenhagen, Micrococcus roseus R27, and Streptococcus pyogenes group A, typ 14. Biochemistry, 5 (12), 3748-3764.
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Tipper, D. J., & Strominger, J. L. (1966). Enzymes that degrade bacterial cell walls. Methods in Enzymology, 8, 685-699. doi:10.1016/0076-6879(66)08124-2
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Petit, J.-F., Munoz, E., Leyh-Bouille, M., & Dierickx, L. (1966). Action des enzymes bactériolytiques, autres que le lysozyme, sur le peptidoglycane des parois cellulaires bactériennes. Exposés Annuels de Biochimie Médicale, 101-110.
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Tipper, D., Birge, C., & Strominger, J. (October 1965). Structure of the Cell Wall of Staphylococcus aureus StrainCopenhagen. VI. The Soluble Glycopeptide and Its Sequential Degradatuib by Peptidases. Biochemistry, 4 (10), 2245-2254.
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Dierickx, L., Leyh-Bouille, M., Strominger, J., Bricas, E., & Nicot, C. (October 1965). Structure of the Cell Wall of Staphylococcus aureus StrainCopenhagen. V. Isolation of Peptidases Active on the Peptide Moiety of the Cell Walls of Some Gram-Positive Bacteria. Biochemistry, 4 (10), 2237-2244.
Peer Reviewed verified by ORBi

Tipper, D. J., Ghuysen, J.-M., & Strominger, J. L. (1965). Structure of the cell wall of Staphylococcus aureus, strain Copenhagen. III. Further studies of the disaccharides. Biochemistry, 4 (3), 468-473. doi:10.1021/bi00879a015
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Tipper, D. J., & Strominger, J. L. (1965). Structure of the Cell Wall of Staphylococcus Aureus, Strain Copenhagen. IV. The Teichoic Acid-Glycopeptide Complex. Biochemistry, 4, 474-485. doi:10.1021/bi00879a016
Peer Reviewed verified by ORBi

Tipper, D. J., Strominger, J. L., & Ghuysen, J.-M. (06 November 1964). Staphylolytic Enzyme from Chalaropsis: Mechanism of Action. Science, 146, 781-782. doi:10.1126/science.146.3645.781
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Strominger, J. L. (01 September 1963). Structure of the Cell Wall of Staphylococcus Aureus, Strain Copenhagen. II. Separation and Structure of Disaccharides. Biochemistry, 2, 1119-1125. doi:10.1021/bi00905a036
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Strominger, J. L. (01 September 1963). Structure of the Cell Wall of Staphylococcus Aureus, Strain Copenhagen. I. Preparation of Fragments by Enzymatic Hydrolysis. Biochemistry, 2 (5), 1110-1119. doi:10.1021/bi00905a035
Peer Reviewed verified by ORBi

Strominger, J. L., & Ghuysen, J.-M. (14 August 1963). On the Linkage between Teichoic Acid and the Glycopeptide in the Cell Wall of Staphylococcus Aureus. Biochemical and Biophysical Research Communications, 12 (5), 418-424. doi:10.1016/0006-291X(63)90117-7
Peer reviewed

Ghuysen, J.-M., Leyh-Bouille, M., & Dierickx, L. (24 September 1962). Structure des parois de Bacillus megaterium KM II. étude des complexes mucopeptidique et phosphomucopolysaccharidique. Biochimica et Biophysica Acta, 63, 297-307. doi:10.1016/0006-3002(62)90683-2
Peer Reviewed verified by ORBi

Dierickx, L., & Ghuysen, J.-M. (26 March 1962). Purification de la [beta]-(1-4)-N-acétylhexosaminidase sécrétée par Streptomyces albus G et active sur les parois de Micrococus lysodeikticus. Biochimica et Biophysica Acta, 58, 7-18. doi:10.1016/0006-3002(62)90811-9
Peer Reviewed verified by ORBi

Ghuysen, J.-M., Leyh-Bouille, M., & Dierickx, L. (1962). Structure des parois de Bacillus megaterium KM I. Isolement de l'amidase et d'un enzyme nouveau sécrétés par Streptomyces albus G et actifs sur les parois de Bacillus megaterium KM et de Micrococcus lysodeikticus. Biochimica et Biophysica Acta, 63 (2), 286-296. doi:10.1016/0006-3002(62)90682-0
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (03 March 1961). Complexe acide téichoique-mucopeptide des parois cellulaires de Bacillus megaterium KM. Biochimica et Biophysica Acta, 50 (3), 413-429. doi:10.1016/0006-3002(61)90001-4
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Ghuysen, J.-M. (1961). Précisions sur la structure des complexes disaccharide-peptide libérés des parois de Micrococcus lysodeikticus sous l'action des β (I → 4) N-acetylhexosaminidases. Biochimica et Biophysica Acta, 47 (3), 561-568. doi:10.1016/0006-3002(61)90551-0
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Salton, M. R. J., & Ghuysen, J.-M. (04 December 1960). Acetylhexosamine compounds enzymically released from Micrococcus lysodeikticus cell walls: III. The structure of di- and tetra-saccharides released from cell walls by lysozyme and Streptomyces F1 enzyme. Biochimica et Biophysica Acta, 45, 355-363. doi:10.1016/0006-3002(60)91458-X
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (03 June 1960). Acetylhexosamine compounds enzymically released from micrococcus lysodeikticus cell walls: II. Enzymic sensitivity of purified acetylhexosamine and acetylhexosamine-peptide complexes. Biochimica et Biophysica Acta, 40, 473-480. doi:10.1016/0006-3002(60)91388-3
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Salton, M. R. J. (03 June 1960). Acetylhexosamine compounds enzymically released from Micrococcus lysodeikticus cell walls: I. Isolation and composition of acetylhexosamine and acetylhexosamine-peptide complexes. Biochimica et Biophysica Acta, 40, 462-472. doi:10.1016/0006-3002(60)91387-1
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (1960). Chimie de la structure des parois cellulaires bactériennes. Industrie Chimique Belge, 9, 1077-1089.

Charlier, R., Prost, M., Dierickx, L., Ghuysen, J.-M., Urbain, M., & Singier, J. (01 March 1959). Le carbamate de propynylcyclohexanol étude pharmacologique et biologique. Archives Internationales de Pharmacodynamie et de Thérapie, 119 (1-2), 264-274.
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Deltour, G. H., Ghuysen, J.-M., & Claus, A. (1959). Effet de la mescaline, du lsd 25 et de dérivés de l'adrenochrome sur la décarboxlyase glutamique du cerveau. Biochemical Pharmacology, 1 (4), 267-272. doi:10.1016/0006-2952(59)90113-3
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Salton, M. R. J., & Ghuysen, J.-M. (1959). The structure of di- and tetra-saccharides released from cell walls by lysozyme and streptomyces F1 enzyme and the [beta] (1-->4) N-acetylhexosaminidase activity of these enzymes. Biochimica et Biophysica Acta, 36 (2), 552-554. doi:10.1016/0006-3002(59)90205-7
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Ghuysen, J.-M. (01 April 1957). Activités bacteriolytiques de l'actinomycetine de Streptomyces albus G. Archives Internationales de Physiologie et de Biochimie, 65 (2), 173-305.
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Salton, M. R. J., & Ghuysen, J.-M. (1957). Action de l'actinomycetine sur les parois cellulaires bacteriennes. Biochimica et Biophysica Acta, 24 (1), 160-173. doi:10.1016/0006-3002(57)90159-2
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Ghuysen, J.-M., & Welsch, M. (10 October 1954). Action de l'actinomycetine sur le fibrinogene et la fibrine. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 148 (19-20), 1694-1697.
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Ghuysen, J.-M., & Welsch, M. (Other coll.). (01 July 1954). Concentration et purification des principes bacteriolytiques de l'actinomycetine par chromatographie sur corps microbiens. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 148 (13-14), 1283-1287.
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Ghuysen, J.-M., Leger, G., & Welsch, M. (Other coll.). (01 April 1954). L'activité antibiotique du type actinomycetine chez les Streptomyces. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 148 (19-20), 1691-1693.
Peer Reviewed verified by ORBi

Ghuysen, J.-M., & Welsch, M. (Other coll.). (01 April 1954). Activite pneumolytique de l'actinomycetine. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 148 (7-8), 729-732.
Peer Reviewed verified by ORBi

Bergamini, L., Ghuysen, J.-M., & Welsch, M. (01 April 1954). L'activité antibiotique du type actinomycetine chez les Streptomyces. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 148 (7-8), 733-736.
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Ghuysen, J.-M., & Welsch, M. (01 August 1953). Influence des ions bivalents et de la témperature sur la production et les activités des principes bacteriolytiques de l'actinomycetine. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 147 (15-18), 1502-1505.
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Ghuysen, J.-M. (01 April 1953). Dualité des principes bactériolytiques de l'actinomycetine. Archives Internationales de Physiologie, 61 (2), 259-260. doi:10.3109/13813455309147728

Welsch, M., & Ghuysen, J.-M. (1953). Activité streptolytique de l'actinomycetine. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 147 (19-20), 1659-1662.
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Ghuysen, J.-M., & Welsch, M. (Other coll.). (01 November 1952). Analyse et purification de l'actinomycetine par absorption. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 146 (21-22), 1812-1815.
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Ghuysen, J.-M. (01 August 1952). L'activité staphylolytique de l'actinomycétine. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 146 (15-16), 1268-1271.

Ghuysen, J.-M., & Desreux, V. (1952). VIII. Analyse chimique et électrotitrimétrique de l'acide ribonucléique de la levure. Bulletin des Sociétés Chimiques Belges, 61, 181-202.
Peer reviewed

Desreux, V., & Ghuysen, J.-M. (1951). VI. La polydispersité de l'acide ribonucléique de la levure. Bulletin des Sociétés Chimiques Belges, 60 (7-8), 410-423.
Peer reviewed

Ghuysen, J.-M. (November 1950). Etude de l'homogénéité de l'acide ribonucléique de la levure. Bulletin des Sociétés Chimiques Belges, 59 (août-septembre), 490-507.
Peer reviewed

Others

Duez, C., Thamm, I., Sapunaric, F., Coyette, J., & Ghuysen, J.-M. (1998). The Division and Cell Wall Gene Cluster of Enterococcus Hirae S185. DNA Sequence: the Journal of DNA Sequencing and Mapping, 9 (3), 149-161. doi:10.3109/10425179809072190
Peer Reviewed verified by ORBi

Fontana, R., Canepari, P., & Ghuysen, J.-M. (1996). Foreword. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 2 (1), 5-R5. doi:10.1089/mdr.1996.2.v
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Granier, B., Duez, C., Lepage, S., Englebert, S., Dusart, J., Dideberg, O., Van Baumeen, J., Frère, J.-M., & Ghuysen, J.-M. (1992). Correction: Primary and predicted secondary structure of the actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the escherichia coli PBP4 (Biochemical Journal(1992)282(786)). Biochemical Journal, 282 (Part 3), 981-982. doi:10.1042/bj2860981c
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Ghuysen, J.-M. (1989). The rigid matrix of bacterial-cell walls - a citation classic commentary on the use of bacteriolytic enzymes in determination of wall structure and their role in cell-metabolism by Ghuyssen,J.M. Current Contents. Agriculture, Biology and Environmental Sciences, (25), 17.
Peer reviewed

Knox, J. R., DeLucia, M. L., Murthy, N. S., Kelly, J. A., Moews, P. C., Frère, J.-M., & Ghuysen, J.-M. (15 January 1979). Crystallographic data for a penicillin receptor : exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 [letter to the editor]. Journal of Molecular Biology, 127 (2), 217-218. doi:10.1016/0022-2836(79)90241-9
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (02 March 1964). Alkaline degradation of the phosphomucopolysaccharide from cell walls of Bacillus megaterium KM. Biochimica et Biophysica Acta, 83 (1), 132-134. doi:10.1016/0926-6526(64)90063-1
Peer Reviewed verified by ORBi

Ghuysen, J.-M. (01 September 1957). Les activités antimicrobiennes des détergents. Revue Médicale de Liège, 12 (17), 457-464.
Peer reviewed

Oral or not published communications in scientific congresses and symposiums (including posters)

Delfosse, P., Ongena, M., Jacques, P., Ghuysen, J.-M., & Thonart, P. (April 1995). Pyoverdine-Mediated Uptake of iron in Pseudomonas putida BTP1 : involvement of a 100 KD IROMP [Poster presentation]. International Conference on Bioiron, Asheville N.C., United States.

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