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Brasseur Josette

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Main Referenced Co-authors
Frère, Jean-Marie  (32)
Dive, Georges  (24)
Ghuysen, Jean-Marie  (18)
Dideberg, Otto (13)
Charlier, Paulette  (11)
Main Referenced Keywords
bêta-lactamases (3); enzyme kinetics (3); Kinetics (3); Models, Molecular (3); Streptomyces (3);
Main Referenced Unit & Research Centers
CIP - Centre d'Ingénierie des Protéines - ULiège [BE] (8)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (41)
Chemistry (14)
Microbiology (10)
Pharmacy, pharmacology & toxicology (9)
Biotechnology (2)

Publications (total 60)

The most downloaded
441 downloads
Elmoualij, B., Duyckaerts, C., Lamotte-Brasseur, J., & Sluse, F. (1997). Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. Yeast, 13 (6), 573-581. doi:10.1002/(SICI)1097-0061(199705)13:6<573::AID-YEA107>3.0.CO;2-I https://hdl.handle.net/2268/32858

The most cited

344 citations (Scopus®)

Galleni, M., Lamotte-Brasseur, J., Rossolini, G. M., Spencer, J., Dideberg, O., & Frère, J.-M. (March 2001). Standard Numbering Scheme for Class B Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (3), 660-3. doi:10.1128/AAC.45.3.660-663.2001 https://hdl.handle.net/2268/188494

De Lemos Esteves, F., Gouders, T., Lamotte-Brasseur, J., Rigali, S., & Frère, J.-M. (February 2005). Improving the alkalophilic performances of the Xyl1 xylanase from Streptomyces sp S38: Structural comparison and mutational analysis. Protein Science: A Publication of the Protein Society, 14 (2), 292-302. doi:10.1110/ps.04978705
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Garsoux, G., Lamotte, J., Gerday, C., & Feller, G. (01 December 2004). Kinetic and structural optimization to catalysis at low temperatures in a psychrophilic cellulase from the Antarctic bacterium Pseudoalteromonas haloplanktis. Biochemical Journal, 384 (Pt 2), 247-253. doi:10.1042/BJ20040325
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De Lemos Esteves, F., Ruelle, V., Gouders, T., Lamotte-Brasseur, J., Quinting, B., Rigali, S., & Frère, J.-M. (December 2004). On the way of understanding the adaptation to extreme pH of family 11 xylanases: Structural comparison and mutational analysis [Poster presentation]. Bioforum, Liège, Belgium.

De Lemos Esteves, F., Ruelle, V., Lamotte-Brasseur, J., Quinting, B., & Frère, J.-M. (01 February 2004). Acidophilic adaptation of family 11 endo--1,4-xylanases: Modeling and mutational analysis. Protein Science: A Publication of the Protein Society, 13 (5), 1209–1218. doi:10.1110/ps.03556104
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Moali, C., Anne, C., Lamotte-Brasseur, J., Groslambert, S., Devreese, B., Van Beeumen, J., Galleni, M., & Frère, J.-M. (April 2003). Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis. Chemistry and Biology, 10 (4), 319-329. doi:10.1016/S1074-5521(03)00070-X
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Docquier, J.-D., Lamotte-Brasseur, J., Galleni, M., Amicosante, G., Frère, J.-M., & Rossolini, G. M. (February 2003). On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy, 51 (2), 257-266. doi:10.1093/jac/dkg067
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Prosperi, C., De Seny, D., Llabres, G., Galleni, M., & Lamotte-Brasseur, J. (December 2002). Active-site mutants of class B beta-lactamases: substrate binding and mechanistic study. Cellular and Molecular Life Sciences, 59 (12), 2136-2143. doi:10.1007/s000180200013
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Lejeune, A., Vanhove, M., Lamotte-Brasseur, J., Pain, R. H., Frère, J.-M., & Matagne, A. (August 2001). Quantitative Analysis of the Stabilization by Substrate of Staphylococcus Aureus Pc1 Beta-Lactamase. Chemistry and Biology, 8 (8), 831-42. doi:10.1016/S1074-5521(01)00053-9
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Mercuri, P., Bouillenne, F., Boschi, L., Lamotte-Brasseur, J., Amicosante, G., Devreese, B., van Beeumen, J., Frère, J.-M., Rossolini, G. M., & Galleni, M. (April 2001). Biochemical Characterization of the Fez-1 Metallo-Beta-Lactamase of Legionella Gormanii Atcc 33297t Produced in Escherichia Coli. Antimicrobial Agents and Chemotherapy, 45 (4), 1254-62. doi:10.1128/AAC.45.4.1254-1262.2001
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Galleni, M., Lamotte-Brasseur, J., Rossolini, G. M., Spencer, J., Dideberg, O., & Frère, J.-M. (March 2001). Standard Numbering Scheme for Class B Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (3), 660-3. doi:10.1128/AAC.45.3.660-663.2001
Peer Reviewed verified by ORBi

Bentahir, M., Feller, G., Aittaleb, M., Lamotte-Brasseur, J., Himri, T., Chessa, J.-P., & Gerday, C. (14 April 2000). Structural, Kinetic, and Calorimetric Characterization of the Cold-Active Phosphoglycerate Kinase from the Antarctic Pseudomonas Sp. Tacii18. Journal of Biological Chemistry, 275 (15), 11147-53. doi:10.1074/jbc.275.15.11147
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Georis, J., De Lemos Esteves, F., Lamotte-Brasseur, J., Bougnet, V., Devreese, B., Giannotta, F., Granier, B., & Frère, J.-M. (March 2000). An Additional Aromatic Interaction Improves the Thermostability and Thermophilicity of a Mesophilic Family 11 Xylanase: Structural Basis and Molecular Study. Protein Science: A Publication of the Protein Society, 9 (3), 466-75. doi:10.1110/ps.9.3.466
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Georis, J., De Lemos Esteves, F., Lamotte-Brasseur, J., Goossens, E., Bougnet, V., Giannotta, F., Granier, B., & Frère, J.-M. (May 1998). Structural basis and molecular study for the thermostability of the G/11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38 [Poster presentation]. Bioforum, Liège, Belgium.

Matagne, A., Lamotte-Brasseur, J., & Frère, J.-M. (01 March 1998). Catalytic Properties of Class a Beta-Lactamases: Efficiency and Diversity. Biochemical Journal, 330 ((Pt 2)), 581-98. doi:10.1042/bj3300581
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Charlier, P., Coyette, J., Dehareng, D., Dive, G., Duez, C., Dusart, J., Fonzé, E., Fraipont, C., Frère, J.-M., Galleni, M., Goffin, C., Joris, B., Lamotte-Brasseur, J., & Nguyen-Distèche, M. (1998). Résistance bactérienne aux beta-lactamines. MS. Medecine Sciences, 14 (5), 544-555. doi:10.4267/10608/1092
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Feller, G., Zekhnini, Z., Lamotte-Brasseur, J., & Gerday, C. (10 February 1997). Enzymes from Cold-Adapted Microorganisms. The Class C Beta-Lactamase from the Antarctic Psychrophile Psychrobacter Immobilis A5. European Journal of Biochemistry, 244 (1), 186-91. doi:10.1111/j.1432-1033.1997.00186.x
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Elmoualij, B., Duyckaerts, C., Lamotte-Brasseur, J., & Sluse, F. (1997). Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. Yeast, 13 (6), 573-581. doi:10.1002/(SICI)1097-0061(199705)13:6<573::AID-YEA107>3.0.CO;2-I
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Guillaume, G., Vanhove, M., Lamotte-Brasseur, J., Ledent, P., Jamin, M., Joris, B., & Frère, J.-M. (1997). Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies. Journal of Biological Chemistry, 272 (9), 5438-44. doi:10.1074/jbc.272.9.5438
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Ledent, P., Duez, C., Vanhove, M., Lejeune, A., Fonze, E., Charlier, P., Rhazi-Filali, F., Thamm, I., Guillaume, G., Samyn, B., Devreese, B., Van Beeumen, J., Lamotte-Brasseur, J., & Frère, J.-M. (1997). Unexpected Influence of a C-Terminal-Fused His-Tag on the Processing of an Enzyme and on the Kinetic and Folding Parameters. FEBS Letters, 413 (2), 194-196. doi:10.1016/S0014-5793(97)00908-3
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Elmoualij, B., Duyckaerts, C., Michel, A., Lamotte-Brasseur, J., & Sluse, F. (1996). Topology of the yeast RIM2 protein, a member of the mitochondrial carrier family [Poster presentation]. 9th Eur. Bioenerg. Conf, Louvain La Neuve, Belgium.

Damblon, C., Raquet, X., Lian, L. Y., Lamotte, J., Fonze, E., Charlier, P., Roberts, G. C., & Frère, J.-M. (1996). The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme. Proceedings of the National Academy of Sciences of the United States of America, 93 (5), 1747-52. doi:10.1073/pnas.93.5.1747
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Elmoualij, B., Duyckaerts, C., Lamotte-Brasseur, J., & Sluse, F. (1996). Phylogenetic classification of the mitochondrial carrier family (MCF) of Saccharomyces cerevisiae [Poster presentation]. 9th Eur. Bioenerg. Conf, Louvain La Neuve, Belgium.

Galleni, M., Lamotte-Brasseur, J., Raquet, X., Dubus, A., Monnaie, D., Knox, J. R., & Frère, J.-M. (11 May 1995). The Enigmatic Catalytic Mechanism of Active-Site Serine Beta-Lactamases. Biochemical Pharmacology, 49 (9), 1171-8. doi:10.1016/0006-2952(94)00502-D
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Galleni, M., Raquet, X., Lamotte-Brasseur, J., Fonze, E., Amicosante, G., & Frère, J.-M. (February 1995). Dd-Peptidases and Beta-Lactamases: Catalytic Mechanisms and Specificities. Journal of Chemotherapy, 7 (1), 3-7. doi:10.1179/joc.1995.7.1.3
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Elmoualij, B., Duyckaerts, C., Lamotte-Brasseur, J., Michel, A., Rentier, B., & Sluse, F. (1995). Localization and transmembrane topology of a new member of the mitochondrial carrier family, the yeast RIM 2 gene product. Archives Internationales de Physiologie, de Biochimie et de Biophysique, 63.

Ghuysen, J.-M., Lamotte-Brasseur, J., Joris, B., & Shockman, G. D. (28 March 1994). Binding Site-Shaped Repeated Sequences of Bacterial Wall Peptidoglycan Hydrolases. FEBS Letters, 342 (1), 23-28. doi:10.1016/0014-5793(94)80577-6
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Marchand-Brynaert, J., Lamotte-Brasseur, J., & Dive, G. (1994). Imidazolidinones structurally-related to penicillins: synthesis, molecular modeling and biological evalutation. Drug Metabolism and Drug Interactions, 11 (2), 85-109.
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Lamotte, J., Knox, J., Kelly, J. A., Charlier, P., Fonze, E., Dideberg, O., & Frère, J.-M. (1994). The structures and catalytic mechanisms of active-site serine beta-lactamases. Biotechnology and Genetic Engineering Reviews, 12, 189-230. doi:10.1080/02648725.1994.10647912
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Matagne, A., Lamotte-Brasseur, J., & Frère, J.-M. (01 October 1993). Interactions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies. European Journal of Biochemistry, 217 (1), 61-67. doi:10.1111/j.1432-1033.1993.tb18218.x
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Matagne, A., Lamotte-Brasseur, J., Dive, G., Knox, J. R., & Frère, J.-M. (01 August 1993). Interactions between Active-Site-Serine Beta-Lactamases and Compounds Bearing a Methoxy Side Chain on the Alpha-Face of the Beta-Lactam Ring: Kinetic and Molecular Modelling Studies. Biochemical Journal, 293 ((Pt 3)), 607-611. doi:10.1042/bj2930607
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Hadonou, A. M., Wilkin, J.-M., Varetto, L., Joris, B., Lamotte-Brasseur, J., Klein, D., Duez, C., Ghuysen, J.-M., & Frère, J.-M. (01 July 1992). Site-Directed Mutagenesis of the Streptomyces R61 Dd-Peptidase. Catalytic Function of the Conserved Residues around the Active Site and a Comparison with Class-a and Class-C Beta-Lactamases. European Journal of Biochemistry, 207 (1), 97-102. doi:10.1111/j.1432-1033.1992.tb17025.x
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Lamotte-Brasseur, J., Jacob-Dubuisson, F., Dive, G., Frère, J.-M., & Ghuysen, J.-M. (10 February 1992). Streptomyces albus G serine β-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes. Biochemical Journal, 282 (Pt 1), 189-195. doi:10.1042/bj2820189
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Oleksyn, B., Suszko-Purzycka, A., Dive, G., & Lamotte-Brasseur, J. (1992). Molecular properties of cinchona alkaloids: a theoretical approach. Journal of Pharmaceutical Sciences, 81 (2), 122-127. doi:10.1002/jps.2600810204
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Joris, B., Ledent, P., Dideberg, O., Fonze, E., Lamotte-Brasseur, J., Kelly, J. A., Ghuysen, J.-M., & Frère, J.-M. (November 1991). Comparison of the Sequences of Class a β-lactamase and of the Secondary Structure Elements of Penicillin-Recognizing Proteins. Antimicrobial Agents and Chemotherapy, 35 (11), 2294-2301. doi:10.1128/AAC.35.11.2294
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Lamotte-Brasseur, J., Dive, G., Dideberg, O., Charlier, P., Frère, J.-M., & Ghuysen, J.-M. (01 October 1991). Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G. Biochemical Journal, 279 (Pt 1), 213-221. doi:10.1042/bj2790213
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Lamotte-Brasseur, J., Dive, G., Lamouri, A., Heymans, F., & Godfroid, J.-J. (20 August 1991). Paf-Receptor. iii. Conformational and Electronic Properties of Paf-Like Agonists and Antagonists. Biochimica et Biophysica Acta, 1085 (1), 91-105. doi:10.1016/0005-2760(91)90236-B
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Lamotte-Brasseur, J., Heymans, F., Dive, G., Lamouri, A., Batt, J.-P., Redeuilh, C., Hosford, D., Braquet, P., & Godfroid, J.-J. (1991). PAF receptor and cache-oreilles effect. Simple PAF antagonists. Lipids, 26 (12), 1167-1171. doi:10.1007/BF02536524
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Godfroid, J.-J., Dive, G., Lamotte-Brasseur, J., Batt, J.-P., & Heymans, F. (1991). PAF receptor structure: a hypothesis. Lipids, 26 (12), 1162-1166. doi:10.1007/BF02536523
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Lamotte, J., Dive, G., & Ghuysen, J.-M. (1991). Conformational analysis of β and γ-lactam antibiotics. European Journal of Medicinal Chemistry, 26 (1), 43-50. doi:10.1016/0223-5234(91)90211-5
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Lamotte-Brasseur, J., Dive, G., Dehareng, D., & Ghuysen, J.-M. (24 July 1990). Electrostatic potential maps at the quantum chemistry level of the active sites of the serine peptidases, α-chymotrypsin and subtilisin. Journal of Theoretical Biology, 145 (2), 183-98. doi:10.1016/S0022-5193(05)80124-9
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Dehareng, D., Dive, G., Lamotte-Brasseur, J., & Ghuysen, J.-M. (1989). Numerical computation of the electrostatic interaction energy between methanol and the dyad water-imidazole. Theoretica Chimica Acta, 76 (2), 85-94. doi:10.1007/BF00532126
Peer reviewed

Dive, G., Godfroid, J.-J., Lamotte-Brasseur, J., Batt, J.-P., Heymans, F., Dupont, L., & Braquet, P. (1989). Paf-Receptor. 1. 'Cache-Oreilles' Effect of Selected High-Potency Platelet-Activating Factor (Paf) Antagonists. Journal of Lipid Mediators, 1 (4, Jul-Aug), 201-15.
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Lamotte, J., Dive, G., Dehareng, D., & Staiger, P. (1988). Molecular graphics software on a raster. Journal of Molecular Graphics, 6 (4), 221. doi:10.1016/S0263-7855(98)80033-7
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Dive, G., Lamotte-Brasseur, J., Reckinger, G., & Ruelle, J.-L. (1986). Representation of energetic and electronic properties in enzymatic reaction pathways. Journal of Molecular Graphics, 4 (4), 226.
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G., & Lamotte-Brasseur, J. (1984). Bacterial cell wall, DD-peptidase and β-lactam antibiotics. Scandinavian Journal of Infectious Diseases, 42, 17-37.
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G., & Lamotte-Brasseur, J. (1984). Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics. Scandinavian Journal of Infectious Diseases, 42, 17-37.
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Charlier, P., Dideberg, O., Jamoulle, J.-C., Frère, J.-M., Ghuysen, J.-M., Dive, G., & Lamotte, J. (1984). Active-site-directed inactivators of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G. Biochemical Journal, 219 (3), 763-772. doi:10.1042/bj2190763
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Lamotte-Brasseur, J., Dive, G., & Ghuysen, J.-M. (1984). On the structural analogy between D-alanyl-D-alanine terminated peptides and β-lactam antibiotics. European Journal of Medicinal Chemistry, 4, 319-330.
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Charlier, P., Dideberg, O., Dive, G., Ghuysen, J.-M., Lamotte-Brasseur, J., & Wery, J. P. (1983). Application de l'informatique dans l'étude des mecanismes enzymatiques a l'échelle moléculaire. Demain. Études et expansion.

Charlier, P., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). The active site of the D-alanyl-D-Alanine-cleaving peptidase. In R. Hakenbeck, J. V. Höltje, ... H. Labischinski (Eds.), Target of Penicillin: The Murein Sacculus of Bacterial Cell Walls, Architecture and Growth (pp. 369-386). De Gruyter.

Charlier, P., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Ghuysen, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). The active sites of the D-alanyl-D-alanine-cleaving peptidases. In R. Hakenbeck, J.-V. Höltje, ... H. Labischinski (Eds.), The Target Penicillin : the Murein Sacculus of Bacterial Cell Walls Architecture and Growth : Proceedings (pp. 369-386). Berlin, Germany: Walter de Gruyter & Co.
Peer reviewed

Ghuysen, J.-M., Charlier, P., Coyette, J., Dideberg, O., Dive, G., Dusart, J., Frère, J.-M., Joris, B., Lamotte-Brasseur, J., Leyh-Bouille, M., & Nguyen-Distèche, M. (1983). Instrinct Resistance to beta-lactam antibiotics at the level of the enzyme sites. Many challenges, some achievements. In B. Wiedemann, J.-M. Guysen, K. H. Spitzy, K. Karrer, S. Brayer, R. Lenzhofer, K. Moser, H. Pichler, ... H. Rainer (Eds.), Symposium Mechanisms of resistance to beta-lactam antibiotics : Proceedings.
Peer reviewed

De Coen, J.-L., Lamotte, J., Ghuysen, J.-M., Frère, J.-M., & Perkins, H. R. (01 December 1981). Conformational analysis of peptide substrates and inhibitors of the Zn2+ G and serine R61 D-alanyl-D-alanine peptidases. European Journal of Biochemistry, 121 (1), 221-232. doi:10.1111/j.1432-1033.1981.tb06452.x
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Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Dideberg, O., Lamotte-Brasseur, J., Perkins, H. R., & De Coen, J.-L. (1981). Penicillins and Δ3-cephalosporins as inhibitors and mechanism-based inactivators of D-alanyl-D-Ala peptidases. In A. S. V. Burgen & G. C. K. Roberts (Eds.), Topics in molecular pharmacology (pp. 64-96). Elsevier.
Peer reviewed

Lamotte, J., Dupont, L., Dideberg, O., Dive, G., & Jamoulle, J.-C. (September 1980). Tetrakis(propylthio)-2,2,6,6' azoxy-3,3' pyridine. Acta Crystallographica. Section B, Structural Crystallography and Crystal Chemistry, 36, 2157-2159. doi:10.1107/S0567740880008217
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Dupont, L., Dideberg, O., Lamotte, J., Kambu, K., & Angenot, L. (1980). Structure d'un nouvel alcaloïde bisindolinique: complexe moléculaire 1:1 Sungucine-Acétone. Acta Crystallographica. Section B, Structural Crystallography and Crystal Chemistry, B 36, 1669-1672.
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Lamotte, J., Dupont, L., Dideberg, O., Kambu, K., & Angenot, L. (1979). Isolation and structure of sungucine, a new type of bisindoline alkaloid. Tetrahedron Letters, (43), 4227-4228. doi:10.1016/S0040-4039(01)86551-5
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Dideberg, O., Lamotte-Brasseur, J., Dupont, L., Campsteyn, H., Vermeire, M., & Angenot, L. (1977). Structure cristalline et moléculaire d'un nouvel alclaoïde bisindolique: complexe moléculaire 1:2 Strychnofoline-Ethanol. Acta Crystallographica. Section B, Structural Crystallography and Crystal Chemistry, B33, 1796-1801.
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Dupont, L., Lamotte-Brasseur, J., Dideberg, O., Campsteyn, H., Vermeire, M., & Angenot, L. (1977). La structure cristalline et moléculaire d'un nouvel alcaloïde bisindolique: la strychnopentamine, C 35, H 43, N 5 0. Acta Crystallographica. Section C, Crystal Structure Communications, B33, 1801-1807.
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Dupont, L., Dideberg, O., Lamotte, J., & Angenot, L. (1976). Structure Cristalline et Moléculaire de la Picrotoxine, C15H16O6.C15H18O7. Acta Crystallographica. Section B, Structural Crystallography and Crystal Chemistry, B32 (11), 2987-2993.
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