The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection context.

Herman, Ludivine; Hubert, Pascale; Herfs, Michael; Kustermans, Gaëlle; Henrotin, Yves; Bousarghin, Latifa; Boniver, Jacques; Delvenne, Philippe

doi:10.1002/eji.201040571

Article (Scientific journals)

The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection context.

Herman, Ludivine; Hubert, Pascale; Herfs, Michael et al.

2010 • In European Journal of Immunology, 40 (11), p. 3075-84

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/77362

DOI
10.1002/eji.201040571

PubMed
21061438

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

ARTICLE vlp LUDIVINE.pdf

Publisher postprint (414.07 kB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Abstract :

[en] Human papillomavirus (HPV) infection, particularly type 16, is causally associated with cancer of the uterine cervix. The progression of cervical lesions suggests that viral antigens are not adequately presented to the immune system. The aim of this study was to determine whether HPV16 viral particles can influence the trafficking of human DC/Langerhans cells (LC), either by direct interactions with DC or following incubation with human normal keratinocytes that are in close contact with LC in the squamous epithelium. We first demonstrated that HPV16 L1 major capsid protein, when self-assembled into virus-like particles (VLP), is able to induce in DC an over-expression of CXC receptor 4 (CXCR4) via the activation of the NF-kappaB signaling pathway and to enhance DC motility in the presence of CXCL12, suggesting an ability to migrate towards lymph nodes. We also showed that conditioned media of HPV16 VLP-treated keratinocytes induce a lower LC migration than those from untreated keratinocytes and that prostaglandin E2 (PGE(2)), detected in HPV16 VLP-treated keratinocyte supernatants, may reduce LC recruitment into the squamous epithelium. Taken together, our data demonstrate that HPV16 VLP may differentially regulate the immune protective response according to their target cells.

Research Center/Unit :

Giga-Cancer - ULiège

Disciplines :

Immunology & infectious disease

Author, co-author :

Herman, Ludivine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Hubert, Pascale ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Herfs, Michael ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Kustermans, Gaëlle ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie

Bousarghin, Latifa

Boniver, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Language :

English

Title :

The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection context.

Publication date :

2010

Journal title :

European Journal of Immunology

ISSN :

0014-2980

eISSN :

1521-4141

Publisher :

VCH Verlagsgesellschaft, Weinheim, Germany

Volume :

Issue :

Pages :

3075-84

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 25 November 2010

Statistics

Number of views

128 (11 by ULiège)

Number of downloads

7 (5 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Bosch, F. X., Manos, M. M., Munoz, N., Sherman, M., Jansen, A. M., Peto, J., Schiffman, M. H. et al., Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J. Natl. Cancer Inst. 1995. 87: 796-802.
Herrington, C. S., Human papillomaviruses and cervical neoplasia. II. Interaction of HPV with other factors. J. Clin. Pathol. 1995. 48: 1-6.
Broker, T. R., Jin, G., Croom-Rivers, A., Bragg, S. M., Richardson, M., Chow, L. T., Vermund, S. H. et al., Viral latency-the papillomavirus model. Dev. Biol. 2001. 106: 443-451.
Ellerbrock, T. V., Chiasson, M. A., Bush, T. J., Wei Sun, X., Sawo, D., Brudney, K. and Wright, T. C., Incidence of cervical squamous intraepithelial lesions in HIV-infected women. J. Am. Med. Assoc. 2000. 283: 1031-1037.
Eiben, G. L., Velders, M. P. and Kast, W. M., The cell-mediated immune response to human papillomavirus-induced cervical cancer: implications for immunotherapy. Adv. Cancer Res. 2002. 86: 113-148.
Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B. and Palucka, K., Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000. 18: 767-811.
Lanzavecchia, A. and Sallusto, F., The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr. Opin. Immunol. 2001. 13: 229-291.
Angeli, V., Ginhoux, F., Llodra, J., Quemeneur, L., Frenette, P. S., Skobe, M., Jessberger, R. et al., B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 2006. 24: 203-215.
Giannini, S. L., Hubert, P., Doyen, J., Boniver, J. and Delvenne, P., Influence of the mucosal epithelium microenvironment on Langerhans cells: implications for the development of squamous intraepithelial lesions of the cervix. Int. J. Cancer. 2002. 97: 654-659.
Roden, R. B., Greenstone, H. L., Kirnbauer, R., Booy, F. P., Jessie, J., Lowy, D. R. and Schiller, J. T., In vitro generation and type-specific neutralization of a human papillomavirus type 16 virion pseudotype. J. Virol. 1996. 70: 5875-5883.
Kirnbauer, R., Booy, F., Chen, N., Lowy, D. R. and Schiller, J. T., Papillomavirus L1 major capsid protein self-assembled into virus-like particles that are highly immunogenic. Proc. Natl. Acad. Sci. USA 1992. 89: 12180-12184.
Hutchinson, D. J. and Klein, K. C., Human Papillomavirus Disease and Vaccines. Am. J. Health-Syst. Pharm. 2008. 65: 2105-2112.
Giannini, S. L., Hanon, E., Moris, P., Van Mechelen, M., Morel, S., Dessy, F., Fourneau, M. A. et al., Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the mpl/aluminium salt combination (AS04) compared to aluminium salt only. Vaccine 2006. 24: 5937-5949.
Rudolf, M. P., Nieland, J. D., Da Silva, D. M., Velders, M. P., Muller, M., Greenstone, H. L., Schiller, J. T. and Kast, W. M., Induction of HPV16 capsid protein-specific human T cell responses by virus-like particles. Biol. Chem. 1999. 380: 335-340.
Lenz, P., Day, P. M., Pang, Y. Y. S., Frye, S. A., Jensen, P. N., Lowy, D. R. and Schiller, J. T., Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells. J. Immunol. 2001. 166: 5346-5355.
Herfs, M., Herman, L., Hubert, P., Minner, F., Arafa, M., Roncarati, P., Henrotin, Y. et al., High expression of PGE 2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. Cancer Immunol. Immunother. 2009. 58: 603-614.
May, M. J. and Ghosh, S., Signal transduction through NF-kB. Immunol. Today 1998. 19: 80-88.
Pierce, J. W., Schoenleber, R., Jesmok, G., Best, J., Moore, S. A., Collins, T. and Gerritsen, M. E., Novel inhibitors of cytokine-induced IkBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J. Biol. Chem. 1997. 272: 21096-21103.
Kobayashi, Y., Staquet, M. J., Zutter-Dambuyant, C., and Schmitt, D., Development of motility of Langerhans cell through extracellular matrix by in vitro hapten contact. Eur. J. Immunol. 1994. 24: 2254-2257.
Drobni, P., Mistry, N., McMillan, N. and Evander, M., Carboxyfluorescein diacetate, succinimidyl ester labeled papillomavirus virus-like particles fluoresce after internalization and interact with heparan sulfate for binding and entry. Virology 2003. 310: 163-172.
Smith, J. L., Campos, S. K. and Ozbun, M. A., Human Papillomavirus Type 31 uses a Caveolin 1- and Dynamin 2-mediated entry pathway for infection of human keratinocytes. J. Virol. 2007. 81: 9922-9931.
Fausch, S. C., Fahey, L. M., Da Silva, D. M. and Kast, W. M., Human Papillomavirus can escape immune recognition through langerhans cell Phosphoinositide 3-kinase activation. J. Immunol. 2005. 174: 7172-7178.
Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S. and Lanzavecchia, A., Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 1998. 28: 2760-2769.
Yan, M., Peng, J., Jabbar, I. A., Liu, X., Filgueira, L., Frazer, I. H. and Thomas, R., Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-kB-mediated signalling, moderated by TGF-β. Immunol. Cell Biol. 2005. 83: 83-91.
Sallusto, F., Mackay, C. R. and Lanzavecchia, A., The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 2000. 18: 593-620.
Kabashima, K., Shiraishi, N., Sugita, K., Mori, T., Onoue, A., Kobayashi, M., Sakabe, J. et al., CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells. Am. J. Pathol. 2007. 171: 1249-1257.
Hargreaves, D. C., Hyman, P. L., Lu, T. T., Ngo, V. N., Bidgol, A., Suzuki, G., Zou, Y. R. et al., A coordinated change in chemokine responsiveness guides plasma cell movements. J. Exp. Med. 2001. 194: 45-56.
Pablos, J. L., Amara, A., Bouloc, A., Santiago, B., Caruz, A., Galindo, M., Delaunay, T. et al., Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Am. J. Pathol. 1999. 155: 1577-1586.
Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S. et al., Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 1998. 187: 129-134.
Daly, A. J., Mcllreavey, L. and Irwin, C. R., Regulation of HGF and SDF-1 expression by oral fibroblasts-implications for invasion of oral cancer. Oral. Oncol. 2008. 44: 646-651.
Hubert, P., Greimers, R., Franzen-Detrooz, E., Doyen, J., Delanaye, P., Boniver, J. and Delvenne, P., In vitro propagated dendritic cells from patients with human papillomavirus-associated preneoplastic lesions of the uterine cervix: use of Flt3 ligand. Cancer Immunol. Immunother. 1998. 47: 81-89.
Hubert, P., Herman, L., Maillard, C., Caberg, J. H., Nikkels, A., Pierard, G., Foidart, J. M. et al., Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo. FASEB J. 2007. 21: 2765-2775.
Kolde, G., Turnover and kinetics of epidermal Langerhans cells and their dendritic precursor cells in experimental contact dermatitis. A correlated ultrastructural-morphometric and immunohistochemical evaluation. Arch. Dermatol. Res. 1996. 288: 197-202.
Narumiya, S., Sugimoto, Y. and Ushikubi, F., Prostanoid Receptors: Structures, Properties, and Functions. Physiol. Rev. 1999. 79: 1193-1226.
Kabashima, K., Sakata, D., Nagamachi, M., Miyachi, Y., Inaba, K. and Narumiya, S., Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat. Med. 2003. 9: 744-749.
Scandella, E., Men, Y., Gillessen, S., Forster, R. and Groettrup, M., Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood 2002. 100: 1354-1361.
Hubert, P., Bousarghin, L., Greimers, R., Franzen-Detrooz, E., Boniver, J. and Delvenne, P., Production of large numbers of Langerhans'cells with intraepithelial migration ability in vitro. Exp. Dermatol. 2005. 14: 469-477.
Gilles, C., Piette, J., Rombouts, S., Laurent, C. and Foidart, J. M., Immortalization of human cervical keratinocytes by human papillomavirus 33. Int. J. Cancer 1993. 53: 872-879.
Bousarghin, L., Hubert, P., Franzen, E., Jacobs, N., Boniver, J. and Delvenne, P., Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells. J. Gen. Virol. 2005. 86: 1297-1305.
Bousarghin, L., Combita-Rojas, A. L., Touze, A., El Mehdaoui, S., Sizaret, P. Y., Bravo, M. M. and Coursaget, P., Detection of neutralizing antibodies against human papillomaviruses (HPV) by inhibition of gene transfer mediated by HPV pseudovirions. J. Clin. Microbiol. 2002. 40: 926-932.
Legrand-Poels, S., Schoonbroodt, S. and Piette, J., Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochem. J. 2000. 349: 765-773.