Article (Scientific journals)
Does an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Art, Tatiana; Duvivier, Dominique Hannia; Votion, Dominique et al.
1998In Journal of Applied Physiology, 84 (3), p. 845-52
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Keywords :
mechanics of breathing; exercise intolerance; chronic airflow obstruction; chronic obstructive pulmonary disease
Abstract :
[en] The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD horses were submitted to a standardized submaximal treadmill exercise test while they were in clinical remission or in acute crisis. Respiratory airflow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded, and arterial and mixed venous blood were analyzed for gas tensions, hemoglobin, and plasma lactate concentrations. O2 consumption, CO2 production, expired minute ventilation, tidal volume, alveolar ventilation, cardiac output, total pulmonary resistance, and mechanical work of breathing were calculated. The results showed that, when submaximally exercised, COPD horses in crisis were significantly more hypoxemic and hypercapnic and that their total pulmonary resistance and mechanical work of breathing were significantly higher and their expired minute ventilation significantly lower than when they were in remission. However, their O2 consumption remained unchanged, which was probably due to the occurrence of compensatory mechanisms, i.e., higher heart rate, cardiac output, and hemoglobin concentration. Last, their net anaerobic metabolism seemed to be more important.
Disciplines :
Veterinary medicine & animal health
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Art, Tatiana ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux
Duvivier, Dominique Hannia
Votion, Dominique  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Anciaux, Nathalie
Vandenput, Sandrina  ;  Université de Liège - ULiège > CARE "Le Réseau des bibliothèques" > Bibliothèque des Sciences de la vie
Bayly, Warwick M;  Washington State University > Department of Veterinary Clinical Sciences
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Does an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Publication date :
1998
Journal title :
Journal of Applied Physiology
ISSN :
8750-7587
eISSN :
1522-1601
Publisher :
American Physiological Society, Bethesda, United States - Maryland
Volume :
84
Issue :
3
Pages :
845-52
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 February 2009

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