[en] The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD horses were submitted to a standardized submaximal treadmill exercise test while they were in clinical remission or in acute crisis. Respiratory airflow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded, and arterial and mixed venous blood were analyzed for gas tensions, hemoglobin, and plasma lactate concentrations. O2 consumption, CO2 production, expired minute ventilation, tidal volume, alveolar ventilation, cardiac output, total pulmonary resistance, and mechanical work of breathing were calculated. The results showed that, when submaximally exercised, COPD horses in crisis were significantly more hypoxemic and hypercapnic and that their total pulmonary resistance and mechanical work of breathing were significantly higher and their expired minute ventilation significantly lower than when they were in remission. However, their O2 consumption remained unchanged, which was probably due to the occurrence of compensatory mechanisms, i.e., higher heart rate, cardiac output, and hemoglobin concentration. Last, their net anaerobic metabolism seemed to be more important.
Disciplines :
Veterinary medicine & animal health Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Art, Tatiana ; Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux
Duvivier, Dominique Hannia
Votion, Dominique ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Anciaux, Nathalie
Vandenput, Sandrina ; Université de Liège - ULiège > CARE "Le Réseau des bibliothèques" > Bibliothèque des Sciences de la vie
Bayly, Warwick M; Washington State University > Department of Veterinary Clinical Sciences
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Does an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Publication date :
1998
Journal title :
Journal of Applied Physiology
ISSN :
8750-7587
eISSN :
1522-1601
Publisher :
American Physiological Society, Bethesda, United States - Maryland
Art, T., L. Anderson, A. J. Woakes, C. Roberts, P. J. Butler, D. H. Snow, and P. Lekeux. Mechanics of breathing during strenuous exercise in thoroughbred horses. Respir. Physiol. 82: 279-283, 1990.
Art, T., P. Lekeux, P. Gustin, D. Desmechet, H. Amory, and M. Paiva. Inertance of the respiratory system in ponies. J. Appl. Physiol. 67: 534-540, 1989.
Bauerle, O., and M. Younes. Role of ventilatory response to exercise in determining exercise capacity in COPD. J. Appl. Physiol. 79: 1870-1877, 1995.
Bayly, W. M., D. R. Hodgson, D. A. Schulz, J. A. Dempsey, and P. D. Gollnick. Exercise-induced hypercapnia in the horse. J. Appl. Physiol. 67: 1958-1966, 1989.
Beaver, W. L., K. Wasserman, and B. J. Whipp. On-line computer analysis and breath-by-breath graphical display of exercise function tests. J. Appl. Physiol. 34: 1958-1966, 1973.
Broadstone, R. V., J. S. Scott, F. J. Derksen, and N. E. Robinson. Effect of atropine in ponies with recurrent airway obstruction. J. Appl. Physiol. 65: 2720-2725, 1988.
Buess, C., P. Pietsch, W. Guggenbuhl, and E. A. Koller. A pulsed diagonal-beam ultrasonic airflow meter. J. Appl. Physiol. 61: 1195-1199, 1986.
Butler, P. J., A. J. Woakes, K. Smale, C. A. Roberts, C. J. Hillidge, D. H. Snow, and D. J. Marlin. Respiratory and cardiovascular adjustments during exercise of increasing intensity and during recovery in thoroughbred racehorse. J. Exp. Biol. 179: 159-180, 1993.
Christley, R. M., D. R. Hodgson, D. L. Evans, and R. J. Rose. Cardiorespiratory response to exercise in horses with different grades of idiopathic laryngeal hemiplegia. Equine Vet. J. 29: 6-10, 1997.
Dempsey, J. A. Is the lung built for exercise? Med. Sci. Sports Exerc. 18: 143-155, 1986.
Dodd, D. S., T. Brancatisano, and L. A. Engel. Chest wall mechanics during exercise in patients with severe chronic airflow obstruction. Am. Rev. Respir. Dis. 129: 33-38, 1984.
Gosselin, R., T. Troosters, and M. Decramer. Peripheral muscle weakness contributes to exercise limitation in COPD. Am. J. Respir. Crit. Care Med. 153: 976-980, 1996.
Jones, N. L., and L. B. Berman. Gas exchange in chronic air-flow obstruction. Am. Rev. Respir. Dis. 129 (2), Suppl.: S81-S83, 1984.
Jones, N. L., G. Jones, and R. H. T. Edwards. Exercise tolerance in chronic airway obstruction. Am. Rev. Respir. Dis. 103: 477-481, 1971.
Killian, K. J., P. Leblanc, D. H. Martin, E. Summers, N. L. Jones, and E. J. M. Campbell. Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation. Am. Rev. Respir. Dis. 146: 935-940, 1992.
Kvart, C., J. Carlsten, L. Dahl, and L. Ryden. Changes in arterial oxygen tension in COPD horses after reduction of exposure to dust in the feed and environment. In: Equine Exercise Physiology 2, edited by J. R. Gillespie and N. E. Robinson. Davis, CA: ICEEP Publications, 1987, p. 753-758.
Levison, H., and R. Cherniack. Ventilatory cost of exercise in chronic obstructive pulmonary disease. J. Appl. Physiol. 25: 21-27, 1968.
Maltais, F., A. A. Simard, C. Simard, J. Jobin, P. Desgagnés, and P. Leblanc. Oxidative capacity of the skeletal muscles and lactic acid kinetics during exercise in normal subjects and in patients with COPD. Am. J. Respir. Crit. Care Med. 153: 288-293, 1996.
Mannix, E. T., M. D. Boska, P. Galassetti, G. Burton, F. Manfredi, and M. O. Farber. Modulation of ATP production by oxygen in obstructive lung disease as assessed by P-MRS. J Appl. Physiol. 78: 2218-2227, 1995.
McFadden, E. R., Jr. Exercise performance in the asthmatic. Am. Rev. Respir. Dis. 129 (2), Suppl.: S84-S87, 1984.
Mead, J. Control of respiratory frequency. J. Appl. Physiol 15: 325-336, 1960.
Nyman, G., M. Björk, P. Funkquist, S. G. B. Persson, and P. D. Wagner. Ventilation-perfusion relationships during graded exercise in Standardbred trotter. Equine Vet. J. 18: 63-69, 1995.
Otis, A. B. The work of breathing. Physiol. Rev. 34: 449-458, 1954.
Persson, S. G. B., and R. Lindberg. Lung biopsy pathology and exercise tolerance in horses with chronic bronchiolitis. In: Equine Exercise Physiology 3, edited by S. G. B. Persson, A. Lindholm, and L. B. Jeffcott. Davis, CA: ICEEP Publications, 1991, p. 457-464.
Potter, W. A., S. Olafsson, and R. E. Hyatt. Ventilatory mechanics and expiratory flow limitation during exercise in patients with obstructive lung disease. J. Clin. Invest. 50: 910-919, 1971.
Roussos, C., and E. J. Campbell. Respiratory muscle energetics. In: Handbook of Physiology. The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. III, pt. 2, chapt. 28, p. 481-509.
Seaman, J., B. K. Erickson, K. Kubo, A. Hiraga, M. Kai, Y. Yamaya, and P. D. Wagner. Exercise induced ventilation/ perfusion inequality in the horse. Equine Vet. J. 27: 104-109, 1995.
Stubbing, D. G., L. D. Pengelly, J. L. C. Morse, and N. L. Jones. Pulmonary mechanics during exercise in subjects with chronic airflow obstruction. J. Appl. Physiol. 49: 511-515, 1980.
Votion, D., K. Munster, B. Genicot, T. Art, and P. Lekeux. Scintigraphical V/Q ratios analysis in healthy and diseased horses: a theoretical approach (Abstract). Pflügers Arch. 429: R10, 1995.
Wagner, P. D. Determinants of maximal oxygen transport and utilization. Annu. Rev. Physiol. 58: 21-50, 1996.
Wagner, P. D., J. R. Gillespie, G. L. Landgren, M. R. Fedde, B. W. Jones, R. M. Debowes, R. L. Pieschl, and H. H. Erickson. Mechanism of exercise-induced hypoxemia in horses. J. Appl. Physiol. 66: 1227-1233, 1989.