airway allergy; IRF3; IRF7; dendritic cell; type I interferon
Abstract :
[en] IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a new pathway potentially implicated in the etiology of airway allergy
Marichal, Thomas ; Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, GIGA-Research and Faculty of Veterinary Medicine
Bedoret, Denis; Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, GIGA-Research and Faculty of Veterinary Medicine
Mesnil, Claire ; Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, GIGA-Research and Faculty of Veterinary Medicine
Pichavant, Muriel; Université de Lille Nord de France, Institut Pasteur de Lille, France > The Lung Infection and Innate Immunity, Team 8, Center for Infection and Immunity of Lille, INSERM U 1019 – CNRS UMR 8204
Goriely, Stanislas; Université Libre de Bruxelles - ULB > The Institute for Medical Immunology
Trottein, François; Université de Lille Nord de France, Institut Pasteur de Lille, France > The Lung Infection and Innate Immunity, Team 8, Center for Infection and Immunity of Lille, INSERM U 1019 – CNRS UMR 8204
Cataldo, Didier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Goldman, Michel; Université Libre de Bruxelles - ULB > The Institute for Medical Immunology
Lekeux, Pierre ; Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, GIGA-Research and Faculty of Veterinary Medicine > Physiologie - Doyen de la Faculté de Médecine vétérinaire
Bureau, Fabrice ✱; Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire
Desmet, Christophe ✱; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
✱ These authors have contributed equally to this work.
Language :
English
Title :
Interferon Response Factor 3 is essential for house dust mite-induced airway allergy
Publication date :
2010
Journal title :
Journal of Allergy and Clinical Immunology
ISSN :
0091-6749
eISSN :
1097-6825
Publisher :
Mosby, St Louis, United States - Missouri
Volume :
126
Issue :
4
Pages :
836-844
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique FRSM - Fonds de la Recherche Scientifique Médicale BELSPO - Belgian Science Policy Office
Funding text :
FNRS (Mandat d'Impulsion Scientifique), Fonds de la Recherche Scientifique Médicale (FRSM; Belgium), and Belgian Programme on Interuniversity Attraction Poles (IUAP; FEDIMMUNE) initiated by the Belgian State (Belgian Science Policy)
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