[en] Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C.
Adesanya S.A., and Sofowora A. Biological standardisation of Zanthoxylum roots for antisickling activity. Planta Medica 48 (1983) 27-33
Adesina S.K. The Nigerian Zanthoxylum; chemical and biological value. African Journal of Traditional, Complementary and Alternative Medicines 2 3 (2005) 282-284
Adjanohoun, E., Alyi, A.M., Aké Assi, L., Baniakina, J., Chibon, P., Cusset, G., Doulou, V., Enzanza, A., Eymé, J., Gondoté, E., Kéita, A., Mbemba, C., Mollet, J., et al., 1986. Contribution aux études ethnobotaniques et floristiques au Togo. ACCT éd., Paris, p. 327, ISBN:92-9028-096.4.
Adjanohoun, E., Alyi, A.M., Aké Assi, L., Baniakina, J., Chibon, P., Cusset, G., Doulou, V., Enzanza, A., Eymé, J., Gondoté, E., Kéita, A., Mbemba, C., Mollet, J., et al., 1989. Contribution aux études ethnobotaniques et floristiques au Bénin. ACCT éd., Paris, p. 481, ISBN:92-9028-152.9.
Bossokpi, I., 2003. Etude des activités biologiques de Fagara zanthoxyloides Lam. (Rutaceae), Pharmacy Thesis, Faculté de Médecine, de Pharmacie et d'Odontostomatologie, University of Bamako, Mali.
Cesquini M., Torsoni M.A., Stoppa G.R., and Ogo S.H. t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids. Biomedicine & Pharmacotherapy 57 3-4 (2003) 124-129
Ekong D.E.U., Okogun J.I., Enyenihi V.U., Balogh-Nair V., Nakanishi K., and Natta C. New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid. Nature 258 (1975) 243-247
Elekwa I., Monanu M.O., and Anosike E.O. Effects of aqueous extracts of Zanthoxylum macrophylla roots on membrane stability of human erythrocytes of different genotypes. Biokemistri 17 1 (2005) 7-12
Elekwa I., Monanu M.O., and Anosike E.O. In vitro effects of aqueous extracts of Zanthoxylum macrophylla roots on adenosine triphosphatases from human erythrocytes of different genotypes. Biokemistri 17 1 (2005) 7-12
Elujoba A.A., and Nagels L. Chromatographic isolation and estimation of zanthoxylol: an antisickling agent from the roots of Zanthoxylum species. Journal of Pharmaceutical and Biomedical Analysis 3 5 (1985) 447-451
Elujoba A.A., and Sofowora E.A. Detection and estimation of total acid in the antisickling fraction of Fagara species. Planta Medica 32 (1977) 54-59
Elujoba A.A., Nagels L., Sofowora A., and Van Dongen W. Chromatographic analysis of antisickling compounds in Zanthoxylum species. International Journal of Pharmaceutics 53 3 (1989) R1-R3
Eshiett I.T., and Taylor D.A.H. Isolation and structure elucidation of some derivatives of dimethylallylcoumarin, chromone, quinoline, and phenol from Fagara species, and from Cedrelopsis grevei. Journal of the Chemical Society [Section] C: Organic 5 (1968) 481-484
Fall A.B., Toppet M., Ferster A., Fondu P., Vanhaelen-Fastré R., and Vanhaelen M. In vitro antisickling activity of cromolyn sodium. British Journal of Haematology 103 (1998) 957-959
Fall A.B., Vanhaelen-Fastré R., Vanhaelen M., Lo I., Toppet M., Ferster A., and Fondu P. In vitro antisickling activity of a rearranged limonoid isolated from Khaya senegalensis. Planta Medica 65 (1999) 209-212
Ouattara A., Guissou I.P., Sawadogo A., and Sawadogo M. Etude comparée du traitement de la crise drépanocytaire par une présentation galénique moderne de deux plantes médicinales (Fagara xanthoxyloides Lam et Calotropis procera Ait) et un médicament usuel de référence (dihydroergotoxine) chez les enfants de 5 à 15 ans à l'hôpital de Ouagadougou. Pharmacien d'Afrique 68 (1992) 19-27
Ouattara B., Angenot L., Guissou I.P., Fondu P., Dubois J., Frédérich M., Jansen O., Van Heugen J.C., Wauters J.N., and Tits M. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65 (2004) 1145-1151
Queiroz E.F., Hay A.E., Chaiib F., van Diemen D., Diallo D., and Hostettmann K. New and bioactive aromatic compounds from Zanthoxylum zanthoxyloides. Planta Medica 72 (2006) 746-750
Sofowora E.A., and Isaacs W.A. Reversal of sickling and crenation in erythrocytes by the root extract of Fagara zanthoxyloides. Lloydia 34 (1971) 383-385
Sofowora E.A., Isaac-Sodeye W.A., and Ogunkoya L.O. Isolation and characterisation of an antisickling agent from Fagara zanthoxyloides root. Lioydia 38 (1975) 169-171
Toppet M., Fall A.B.K., Ferster A., Fondu P., Mélot C., Vanhaelen-Fastré R., and Vanhaelen M. Antisickling activity of sodium cromoglycate in sickle-cell disease. The Lancet 356 (2000) 309-312
