LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design

Marini Djang'Eing'A, Roland; Chiap, Patrice; Boulanger, Bruno; Dewé, Walthère; Hubert, Philippe; Crommen, Jacques

doi:10.1002/jssc.200301367

Article (Scientific journals)

LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design

Marini Djang'Eing'A, Roland; Chiap, Patrice; Boulanger, Bruno et al.

2003 • In Journal of Separation Science, 26 (9-10), p. 809-817

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/5362

DOI
10.1002/jssc.200301367

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Keywords :

LC optimization; experimental design; timolol maleate; enantiomeric purity; related substances

Abstract :

[en] A liquid chromatography (LC) method using cellulose tris(3,5-dimethylphenylcarbamate) (5 mum) as chiral stationary phase (CSP) and a mixture of hexane, 2-propanol, and diethylamine as mobile phase was developed for the simultaneous determination of R-timolol and other potential related substances in S-timolol maleate samples. An experimental design was elaborated in order to test the effects of the different selected factors. Three factors were studied simultaneously, namely the concentrations of 2-propanol and diethylamine as well as the column temperature. The effects of these factors were evaluated statistically. Optimal LC conditions were then deduced by applying a multicriteria decision making approach, namely Derringer's desirability function, for the responses of interest. The developed LC method was compared to the European Pharmacopoeia method and was applied to the determination of R-timolol and other related substances in several samples of S-timolol maleate from different sources.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Marini Djang'Eing'A, Roland ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Chiap, Patrice ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Boulanger, Bruno ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Dewé, Walthère ; Université de Liège - ULiège > Analyse des médicaments

Hubert, Philippe ; Université de Liège - ULiège > Chimie analytique

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design

Publication date :

July 2003

Journal title :

Journal of Separation Science

ISSN :

1615-9306

eISSN :

1615-9314

Publisher :

Wiley-V C H Verlag Gmbh, Weinheim, Germany

Volume :

Issue :

9-10

Pages :

809-817

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 April 2010

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