Reference : Identification of a pharmacophore of SKCa channel blockers
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Biochemistry, biophysics & molecular biology
Identification of a pharmacophore of SKCa channel blockers
Dilly, Sébastien mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Graulich, Amaury [Université de Liège - ULg > > Chimie pharmaceutique >]
Farce, Amaury [> > > >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Liégeois, Jean-François mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Chavatte, Philippe [> > > >]
Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd
Yes (verified by ORBi)
[en] SK channels ; blockers ; apamin ; dequalinium ; pharmacophore ; model
[en] Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified in different parts of the brain. Activation of the SK channels by a rise in intracellular calcium leads to the hyperpolarisation of the membrane, reducing cell excitability. Blocking the SK channels might be beneficial in the treatment of depression, Parkinson's disease and cognitive disorders. However, few blockers of SK channels have been characterized. In this study, a pharmacophoric model of SK channels blockers is presented. It is based on a series of nonpeptidic compounds and apamin, a peptidic blocker. To create the pharmacophore model, the conformational space of nonpeptidic blockers was investigated to generate a series of distance constraints applied to a simulated annealing study of apamin. The resulting conformation was superimposed with the nonpeptidic blockers to give a pharmacophore.
Researchers ; Professionals

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