  | Vitello, R.* , Taouba, H.* , Derand, M., & Liégeois, J.-F. (2024). The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels. ACS Medicinal Chemistry Letters. doi:10.1021/acsmedchemlett.3c00452  Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
Robaye, L., Engel, D., Liégeois, J.-F., Kerff, F., Quertemont, E., & Seutin, V. (24 November 2023). Organotypic slice cultures from the P1 mouse dorsal raphe: Methodological development and first results [Poster presentation]. National committee of physiology and pharmacology, Autumn Meeting, Brussels, Belgium. |
 | Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (07 September 2023). Towards a high-throughput mass spectrometry methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Poster presentation]. 39ème Journées Françaises de Spectrométrie de Masse, Marseille, France. |
  | Vitello, R., Taouba, H., Pereira Barbon, D., Tumanov, N., Wouters, J., Seutin, V., & Liégeois, J.-F. (10 May 2023). Tetrahydroisoquinoline derivatives as blockers of SK channels: A new pharmacophore identified [Poster presentation]. Cambridge Ion Channels Forum 2023, Cambridge, United Kingdom. |
| Taouba, H., Vitello, R., Frederich, M., Wouters Johan, & Liégeois, J.-F. (28 April 2023). SMALL-CONDUCTANCE Ca2+-ACTIVATED K+ CHANNELS, A NOVEL TARGET FOR THE ALKALOIDS CEPHARANTHINE AND BERBAMINE [Paper presentation]. 21st FORUM OF PHARMACEUTICAL SCIENCES, Blankenberge, Belgium. |
 | Vitello, R., Taouba, H., Pereira Barbon, D., Tumanov, N., Wouters, J., Seutin, V., & Liégeois, J.-F. (28 April 2023). A Not-So-Simple Simplifictaion [Poster presentation]. PhysPhar Spring meeting 2023, Bruxelles, Belgium. |
| Taouba, H., Vitello, R., & Liégeois, J.-F. (01 February 2023). CEPHARANTHINE AND BERBAMINE HAVE A SIGNIFICANT AFFINITY FOR THE SMALL CONDUCTANCE Ca 2+ - ACTIVATED K+ CHANNELS [Paper presentation]. C.I.R.M. day 2023, Liège, Belgium. |
 | Falinski, S. P., Taouba, H., Vitello, R., & Liégeois, J.-F. (01 February 2023). The prospect of using a thallium flux assay to study native and mutated hSK2 & hSK3 channels in transiently transfected HEK293 cells [Poster presentation]. CIRM Day 2023, Liège, Belgium. Editorial reviewed |
Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (18 October 2022). Towards a high-throughput MS methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Paper presentation]. Congrès International de Toxinologie - IST, Abu-Dhabi, United Arab Emirates. |
Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (07 October 2022). Towards a high-throughput mass spectrometry methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Poster presentation]. BSMS 2022, Braine l'Alleud, Belgium. |
Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (01 September 2022). HIGH-THROUGHPUT MASS SPECTROMETRY METHODOLOGY TO FISH PEPTIDE TOXINS FROM CRUDE VENOMS BY AFFINITY CAPTURE ON CELL MEMBRANE RECEPTORS [Paper presentation]. 2022 International Mass Spectrometry Conference, Maastricht, Netherlands. |
 | Taouba, H., Vitello, R., Lumb, J.-P., Seutin, V., Frederich, M., & Liégeois, J.-F. (19 November 2021). A NEW APPROACH FOR THE TREATMENT OF MALARIA THROUGH SK CHANNEL MODULATION ? [Poster presentation]. MedChem 2021, Liège, Belgium. |
 | Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, S., Engel, D., Liégeois, J.-F., Lakaye, B., Roeper, J., & Seutin, V. (01 October 2021). The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology, 197, 1-15. doi:10.1016/j.neuropharm.2021.108722 Peer Reviewed verified by ORBi |
Vitello, R., Seutin, V., Badarau, E., & Liégeois, J.-F. (28 May 2021). Benzhydrol analogues of bis-isoquinoliniums : chiral entities with potential to interact with SK channels [Paper presentation]. 2nd FNRS Med Chem Symposium, Belgium. |
 | Wanko Nembot, A. M., Hayen, J.-L., Vitello, R., Damblon, C., & Liégeois, J.-F. (26 May 2021). Quantification of 2-disulfide bonded isomers of apamin, a peptidic toxin, leads to the observation of a structural rearrangement [Poster presentation]. CIRM-Day. |
 | Taouba, H., Vitello, R., Lumb, J.-P., Seutin, V., Frederich, M., & Liégeois, J.-F. (26 May 2021). Could Bis-THIQ compounds inhibit plasmodial growth through SK channel interaction ? [Poster presentation]. CIRM-day, LIEGE, Belgium. |
 | Andrade, Y., Ropke, J., Viana, T., Fanelli, C., Minaldi, E., Batista, L., Issy, A., Del Bel, E., Rodrigues, L., Liégeois, J.-F., & Moreira, F. (2021). Effects of JL13, a pyridobenzoxazepine compound, in dopaminergic and glutamatergic models of antipsychotic activity. Behavioural Pharmacology, 32, 2-8. doi:10.1097/FBP.0000000000000595 Peer Reviewed verified by ORBi |
| Vitello, R., Kerff, F., & Liégeois, J.-F. (2021). Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents. Acta physiologica, 231, 13574. doi:10.1111/apha.13574 Peer reviewed |
Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Lakaye, B., Liégeois, J.-F., Roeper, J., & Seutin, V. (22 May 2020). On the path to understanding pacemaking of dopaminergic neurons [Poster presentation]. Virtual Dopamine Meeting. |
Vitello, R., & Liégeois, J.-F. (23 February 2017). Chiral tools to explore SK channel functions [Paper presentation]. CIRM seminar. |
| Dilly, S., & Liégeois, J.-F. (2016). Structural insights into 5-HT1A/D4 selectivity of WAY-100635 analogues: molecular modeling, synthesis and in vitro binding. Journal of Chemical Information and Modeling, 56, 1324-1331. doi:10.1021/acs.jcim.5b00753 Peer Reviewed verified by ORBi |
 | Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J., & Liégeois, J.-F. (05 June 2014). A PREFERENTIAL FOLDED CONFORMATION OF SOME BIS-(8-ISOPROPYL-ISOQUINOLINIUM) DERIVATIVES EXPLAINS STEREOSELECTIVE REDUCTION BY SODIUM BOROHYDRIDE [Poster presentation]. 28èmes Journées Franco-Belges de Pharmacochimie, Metz, France. |
| Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J., & Liégeois, J.-F. (2014). Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride. Journal of Molecular Structure. doi:10.1016/j.molstruc.2014.06.042 Peer Reviewed verified by ORBi |
| Badarau, E.* , Dilly, S.* , Wouters, J., Seutin, V., & Liégeois, J.-F. (2014). Chemical modifications of the N-methyl laudanosine scaffold point to new directions for SK channels exploration. Bioorganic and Medicinal Chemistry Letters, 24, 5616-5620. doi:10.1016/j.bmcl.2014.10.083 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Liégeois, J.-F., Lespagnard, M., Meneses Salas, E., Mangin, F., Scuvée-Moreau, J., & Dilly, S. (2014). Enhancing a CH-pi interaction to increase the affinity for 5-HT1A receptors. ACS Medicinal Chemistry Letters, 5, 358-362. doi:10.1021/ml4004843 Peer Reviewed verified by ORBi |
| Liégeois, J.-F., Wouters, J., Seutin, V., & Dilly, S. (2014). Bis-(1,2,3,4-tetrahydroisoquinolinium): a chiral scaffold for developing high affinity ligands for SK channels. ChemMedChem, 9, 737-740. doi:10.1002/cmdc.201400028 Peer Reviewed verified by ORBi |
| Liégeois, J.-F., Seutin, V., & Dilly, S. (09 November 2013). Increased affinity of N-Methyl-AG525 stereoisomers for SK2 and SK3 channels [Poster presentation]. 43th Annual Meeting Neuroscience, San Diego, United States. |
| Liégeois, J.-F., Lespagnard, M., Meneses-Salas, E., Mangin, F., & Dilly, S. (July 2013). CHANGING THE ELECTRONIC DENSITY OF THE DISTAL PHENYL RING OF 4-ARYL-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES TO INFLUENCE THE AFFINITY FOR 5-HT1A RECEPTORS [Poster presentation]. Rencontres Internationales de Chimie Thérapeutique (RICT) 2013, Nice, France. |
 | Dilly, S., & Liégeois, J.-F. (June 2013). A HYDROGEN BOND INFLUENCES THE 5-HT1A/D4 SELECTIVITY OF WAY-100635 ANALOGUES: AN IN SILICO APPROACH [Poster presentation]. 27èmes Journées franco-belges de Pharmacochimie et 21èmes Conférences européennes du GP2A, Lille, France. |
 | Dilly, S., Philippart, F., Lamy, C., Poncin, S., Snyders, D., Seutin, V., & Liégeois, J.-F. (2013). The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels. Biochemical Pharmacology, 85, 560-569. doi:10.1016/j.bcp.2012.12.015 Peer Reviewed verified by ORBi |
 | Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Oprean, R., Badarau, E., Dufour, F., Dossou, K. S. S., Fillet, M., Liégeois, J.-F., Hubert, P., & Rozet, E. (2013). Implementation of a Design Space Approach for Enantiomeric Separations in Polar Organic Solvent Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 74, 273-283. doi:10.1016/j.jpba.2012.10.015 Peer Reviewed verified by ORBi |
 | Dilly, S., Mangin, F., Joly, B., Scuvée-Moreau, J., Evans, J., Setola, V., Roth, B., & Liégeois, J.-F. (24 May 2012). PHARMACOMODULATIONS DU WAY-100635 : DE NOUVELLES PISTES DANS LA CONCEPTION D’ANTAGONISTES SÉLECTIFS DES RÉCEPTEURS 5-HT1A [Poster presentation]. 26èmes Journées Franco-Belges de Pharmacochimie 2012, Orléans, France. |
 | Dilly, S., Poncin, S., Lamy, C., Liégeois, J.-F., & Seutin, V. (April 2012). Physiologie, pharmacologie et modélisation de canaux potassiques : zoom sur les canaux SK. MS. Medecine Sciences, 28, 395-402. doi:10.1051/medsci/2012284017 Peer Reviewed verified by ORBi |
 | Dilly, S., Lamy, C., Poncin, S., Seutin, V., Snyders, D., & Liégeois, J.-F. (16 March 2012). Interactions of apamin with pore mutated SK3 channels [Poster presentation]. Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Spring Meeting 2010, Brussels, Belgium. |
 | Mangin, F., Dilly, S., Joly, B., Scuvée-Moreau, J., Evans, J., Setola, V., Roth, B., & Liégeois, J.-F. (2012). Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. Bioorganic and Medicinal Chemistry Letters. doi:10.1016/j.bmcl.2012.05.119 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., DEVILLE, M., Dilly, S., Lamy, C., Mangin, F., Résimont, M., & Tarazi, F. (2012). New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation. Journal of Medicinal Chemistry, 55 (1572), 1582. doi:10.1021/jm2013419 Peer Reviewed verified by ORBi |
 | Badarau, E., Dilly, S., Dufour, F., Poncin, S., Seutin, V., & Liégeois, J.-F. (15 November 2011). Synthesis and radioligand binding studies of bis-(8-isopropylisoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels. Bioorganic and Medicinal Chemistry Letters, 21 (22), 6756-6759. doi:10.1016/j.bmcl.2011.09.043 Peer Reviewed verified by ORBi |
 | Dilly, S., Lamy, C., Marrion, N., Liégeois, J.-F., & Seutin, V. (16 August 2011). Ion channel modulators: more diversity than previously thought. Chembiochem: A European Journal of Chemical Biology, 12 (12), 1808-1812. doi:10.1002/cbic.201100236 Peer Reviewed verified by ORBi |
Vignisse, J., Liégeois, J.-F., Wins, P., & Bettendorff, L. (July 2011). Thiamin derivatives in the brain of a mouse model of Alzheimer's disease and in cultured Neuroblastoma cells treated with benfotiamine [Poster presentation]. FENS/IBRO Summer School 2011: Metabolic Aspects of Chronic Brain Diseases, Gunzburg, Germany. |
| Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Rozet, E., Oprean, R., Badarau, E., Dufour, F., Liégeois, J.-F., & Hubert, P. (2011). Implementation of a design space approach for enatiomeric separations in polar organic solvent chromatography [Poster presentation]. 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Budapest, Hungary. |
 | Dilly, S., Scuvée-Moreau, J., Wouters, J., & Liégeois, J.-F. (2011). The 5-HT1A agonism potential of substituted-piperazine-ethyl-amide derivatives is conserved in the hexyl homologues: molecular modeling and pharmacological evaluation. Journal of Chemical Information and Modeling, 51 (11), 2961-2966. doi:10.1021/ci200313r Peer Reviewed verified by ORBi |
 | Weatherall, K., Seutin, V., Liégeois, J.-F., & Marrion, N. (2011). Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channel. Proceedings of the National Academy of Sciences of the United States of America, 108 (45), 18488-18493. doi:10.1073/pnas.1110724108 Peer Reviewed verified by ORBi |
 | Dilly, S., & Liégeois, J.-F. (2011). Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study. Journal of Computer-Aided Molecular Design, 25 (2), 163-169. doi:10.1007/s10822-010-9407-8 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., & Dilly, S. (16 November 2010). Binding properties of clozapine and related compounds on native D2 dopamine receptors in normal and oxidative medium [Poster presentation]. 40th Annual Meeting Neuroscience, San Diego, United States. |
 | Dilly, S., Lamy, C., Snyders, D., Liégeois, J.-F., & Seutin, V. (16 October 2010). Block of SK channels by the sigma agonist 1,3-di-o-tolyl-guanidine: evidence for a novel site of action for SK blockers [Poster presentation]. Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Autumn Meeting 2010, Brussels, Belgium. |
 | Dilly, S., Lamy, C., Seutin, V., & Liégeois, J.-F. (20 May 2010). Etude du mode de liaison des canaux potassiques de type SK et l’apamine par modélisation moléculaire [Poster presentation]. 24èmes JOURNEES FRANCO-BELGES DE PHARMACOCHIMIE, Bruxelles, Belgium. |
 | Lamy, C.* , Goodchild, S. J.* , Weatherall, K. L., Jane, D. E., Liégeois, J.-F., Seutin, V.* , & Marrion, N. V.*. (2010). Allosteric block of KCa2 channels by apamin. Journal of Biological Chemistry, 287, 27067-77. doi:10.1074/jbc.M110.110072 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Drion, G., Bonjean, M., Waroux, O., Scuvée-Moreau, J., Liégeois, J.-F., Sejnowski, T., Sepulchre, R., & Seutin, V. (2010). M-type channels selectively control bursting in rat dopaminergic neurons. European Journal of Neuroscience, 31, 827-835. doi:10.1111/j.1460-9568.2010.07107.x Peer Reviewed verified by ORBi |
 | Wouters, J., Elasaad, K., Norberg, B., Graulich, A., & Liégeois, J.-F. (2010). Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline). European Journal of Medicinal Chemistry, 45, 3240-3244. doi:10.1016/j.ejmech.2010.03.020 Peer Reviewed verified by ORBi |
 | Résimont, M., & Liégeois, J.-F. (2010). Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, alpha(2A), D4.2, D3 and D2L receptors. Bioorganic and Medicinal Chemistry Letters, 20, 5199-5202. doi:10.1016/j.bmcl.2010.07.002 Peer Reviewed verified by ORBi |
 | Dilly, S., Graulich, A., & Liégeois, J.-F. (January 2010). Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: A new step towards the design of high-affinity 5-HT1A ligands. Bioorganic and Medicinal Chemistry Letters, 20 (2), 1118-1123. doi:10.1016/j.bmcl.2009.12.027 Peer Reviewed verified by ORBi |
 | Dilly, S., Lamy, C., Liégeois, J.-F., & Seutin, V. (2010). Combined experimental and computational approaches to study the action of blockers of small conductance calcium-activated potassium (SK) channels. Acta Physiologica Scandinavica, 199 (supplement 678), 10. |
| Lamy, C., Scuvée-Moreau, J., Dilly, S., Liégeois, J.-F., & Seutin, V. (2010). The sigma agonist 1,3-di-o-tolylguanidine directly blocks SK channels in dopaminergic neurons and in cell lines. European Journal of Pharmacology, 641, 23-28. doi:10.1016/j.ejphar.2010.05.008 Peer Reviewed verified by ORBi |
 | Graulich, A., Léonard, M., Résimont, M., Huang, X.-P., Roth, B. L., & Liégeois, J.-F. (2010). Chemical Modifications on 4-Arylpiperazine-Ethyl Carboxamide Derivatives Differentially Modulate Affinity for 5-HT1A, D4.2, and alpha(2A) Receptors: Synthesis and In Vitro Radioligand Binding Studies. Australian Journal of Chemistry, 63, 56-67. doi:10.1071/CH09353 Peer Reviewed verified by ORBi |
 | Dilly, S., Graulich, A., & Liégeois, J.-F. (14 May 2009). Conformational analysis of new 5-HT1A ligands by molecular modeling [Paper presentation]. 14th Forum of Pharmaceutical Sciences, Blankenberge, Belgium. |
 | Lamy, C., Scuvée-Moreau, J., Dilly, S., Goodchild, S., Marrion, N., Liégeois, J.-F., & Seutin, V. (17 November 2008). Direct block of SK2 and SK3 current by the sigma agonist 1,3-di-(2-tolyl)guanidine [Poster presentation]. 38th Annual Meeting Neuroscience, Washington, United States. |
 | Rouchet, N., Waroux, O., Lamy, C., Massotte, L., Scuvée-Moreau, J., Liégeois, J.-F., & Seutin, V. (28 September 2008). SK Channel blockade promotes burst firing in dorsal raphe serotonergic neurons. European Journal of Neuroscience, 28 (6), 1108-15. doi:10.1111/j.1460-9568.2008.06430.x Peer Reviewed verified by ORBi |
 | Dilly, S., Graulich, A., Chavatte, P., Seutin, V., & Liégeois, J.-F. (30 May 2008). Molecular modelling study of bis-isoquinolinium derivatives as small conductance Ca2+ - activated K+ channel blockers [Poster presentation]. 22èmes journées franco-belges de pharmacochimie, Caen, France. |
| Rouchet, N., Waroux, O., Alix, P., Scuvée-Moreau, J., Liégeois, J.-F., & Seutin, V. (17 May 2008). SK Channel blockade promotes bursting in vivo in dorsal raphe serotonergic neurons. Acta Physiologica, 194 (supll. 666), 01. Peer Reviewed verified by ORBi |
| Neny, M., Lemmer, Y., Graulich, A., Alleva, L., Piazza, P. V., Seutin, V., Spampinato, U., & Liégeois, J.-F. (2008). The SK channel blocker AG525E1 increases locomotor activity and in vivo dopamine release in the rat nucleus accumbens. In P. E. M. Phillips, S. G. Sandberg, S. Ahn, ... A. G. Phillips (Eds.), Monitoring Molecules in Neuroscience - Proceedings of the 12th International Conference on In Vivo Methods (pp. 267-270). Vancouver, Canada: University of Bristish Columbia. Peer reviewed |
 | Graulich, A., Lamy, C., Alleva, L., Dilly, S., Chavatte, P., Wouters, J., Seutin, V., & Liégeois, J.-F. (2008). Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers. Bioorganic and Medicinal Chemistry Letters, 18 (11), 3440-3445. doi:10.1016/j.bmcl.2008.03.069 Peer Reviewed verified by ORBi |
Rouchet, N., Waroux, O., Scuvée-Moreau, J., Lamy, C., Graulich, A., Liégeois, J.-F., & Seutin, V. (04 November 2007). Direct induction of burst firing by SK channel blockade in serotonergic neurons in vivo [Paper presentation]. Neuroscience 2007, San Diego, United States - California. |
 | Graulich, A., Dilly, S., Farce, A., Scuvée-Moreau, J., Waroux, O., Lamy, C., Chavatte, P., Seutin, V., & Liégeois, J.-F. (18 October 2007). Synthesis and Radioligand Binding Studies of Bis-Isoquinolinium Derivatives as Small Conductance Ca(2+)-Activated K(+) Channel Blockers. Journal of Medicinal Chemistry, 50 (21), 5070-5075. doi:10.1021/jm070412j Peer Reviewed verified by ORBi |
 | Seutin, V., & Liégeois, J.-F. (July 2007). SK channels are on the move. British Journal of Pharmacology, 151 (5), 568-570. doi:10.1038/sj.bjp.0707282 Peer Reviewed verified by ORBi |
 | Graulich, A., Norberg, B., Liégeois, J.-F., & Wouters, J. (July 2007). (+/-)-2-Benzoyl-8-ethyl-1,2-dihydro-isoquinoline-1-carbonitrile: an original Reissert compound. Acta Crystallographica. Section E, Structure Reports Online, 63 (Part 7), 3161-U3073. doi:10.1107/S1600536807027729 Peer Reviewed verified by ORBi |
 | Ris, L., Capron, B., Sclavons, C., Liégeois, J.-F., Seutin, V., & Godaux, E. (June 2007). Metaplastic effect of apamin on LTP and paired-pulse facilitation. Learning and Memory, 14 (6), 390-399. doi:10.1101/lm.571007 Peer Reviewed verified by ORBi |
 | Carato, P., Graulich, A., Jensen, N., Roth, B. L., & Liégeois, J.-F. (15 March 2007). Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D-2L, D-4.2, and 5-HT2A receptors. Bioorganic and Medicinal Chemistry Letters, 17 (6), 1565-1569. doi:10.1016/j.bmcl.2006.12.096 Peer Reviewed verified by ORBi |
 | Carato, P., Graulich, A., Jensen, N., Roth, B. L., & Liégeois, J.-F. (15 March 2007). Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D-2L, D-4.2, and 5-HT2A receptors. Bioorganic and Medicinal Chemistry Letters, 17 (6), 1570-1574. doi:10.1016/j.bmcl.2006.12.106 Peer Reviewed verified by ORBi |
 | Tarazi, F. I., Moran-Gates, T., Gardner, M. P., Graulich, A., Lamy, C., & Liégeois, J.-F. (2007). Long-term effects of JL 13, a potential atypical antipsychotic, on Ionotropic glutamate receptors. Journal of Molecular Neuroscience, 32 (3), 192-198. doi:10.1007/s12031-007-0034-3 Peer Reviewed verified by ORBi |
 | Graulich, A., Scuvée-Moreau, J., Alleva, L., Lamy, C., Waroux, O., Seutin, V., & Liégeois, J.-F. (30 November 2006). Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+- activated K+ channels. Journal of Medicinal Chemistry, 49 (24), 7208-7214. doi:10.1021/jm0607395 Peer Reviewed verified by ORBi |
Alleva, L., Rouchet, N., Waroux, O., Lamy, C., Scuvée-Moreau, J., Graulich, A., Liégeois, J.-F., & Seutin, V. (17 October 2006). Effect of SK channel blockade on the firing of dorsal raphe neurons in anaesthetized rats [Poster presentation]. 2006 Neuroscience Meeting Planner, Atlanta, United States. |
 | Moran-Gates, T., Massari, C., Graulich, A., Liégeois, J.-F., & Tarazi, F. I. (15 August 2006). Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes. Journal of Neuroscience Research, 84 (3), 675-682. doi:10.1002/jnr.20972 Peer Reviewed verified by ORBi |
 | Dilly, S., Graulich, A., Farce, A., Seutin, V., Liégeois, J.-F., & Chavatte, P. (December 2005). Identification of a pharmacophore of SKCa channel blockers. Journal of Enzyme Inhibition and Medicinal Chemistry, 20 (6), 517-523. doi:10.1080/14756360500210989 Peer Reviewed verified by ORBi |
 | Waroux, O., Massotte, L., Alleva, L., Graulich, A., Thomas, E., Liégeois, J.-F., Scuvée-Moreau, J., & Seutin, V. (December 2005). SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. European Journal of Neuroscience, 22 (12), 3111-3121. doi:10.1111/j.1460-9568.2005.04484.x Peer Reviewed verified by ORBi |
 | de Ruyck, J., de Hassonville, S. H., Liégeois, J.-F., & Wouters, J. (November 2005). Cyproterone and a comparison with its acetate ester. Acta Crystallographica. Section E, Structure Reports Online, 61 (Part 11), 3576-O3578. doi:10.1107/S1600536805031673 Peer Reviewed verified by ORBi |
 | Graulich, A., Scuvée-Moreau, J., Seutin, V., & Liégeois, J.-F. (28 July 2005). Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine. Journal of Medicinal Chemistry, 48 (15), 4972-4982. doi:10.1021/jm049025p Peer Reviewed verified by ORBi |
 | Dilly, S., Graulich, A., Farce, A., Seutin, V., Liégeois, J.-F., & Chavatte, P. (28 January 2005). Recherche d’un pharmacophore de ligands de canaux SK par Modélisation Moléculaire [Paper presentation]. 12ème Journée Jeunes Chercheurs, Institut Curie, Paris, France. |
 | Graulich, A., Mercier, F., Scuvée-Moreau, J., Seutin, V., & Liégeois, J.-F. (2005). Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers. Bioorganic and Medicinal Chemistry, 13 (4), 1201-9. doi:10.1016/j.bmc.2004.11.025 Peer Reviewed verified by ORBi |
 | Scuvée-Moreau, J., Boland, A., Graulich, A., Van Overmeire, L., D'hoedt, D., Graulich-Lorge, F., Thomas, E., Abras, A., Stocker, M., Liégeois, J.-F., & Seutin, V. (November 2004). Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices. British Journal of Pharmacology, 143 (6), 753-764. doi:10.1038/sj.bjp.0705979 Peer Reviewed verified by ORBi |
 | Henry de Hassonville, S., Chiap, P., Liégeois, J.-F., Evrard, B., Delattre, L., Crommen, J., Piel, G., & Hubert, P. (21 September 2004). Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin. Journal of Pharmaceutical and Biomedical Analysis, 36 (1), 133-143. doi:10.1016/j.jpba.2004.05.023 Peer Reviewed verified by ORBi |
 | Graulich, A., & Liégeois, J.-F. (2004). A rapid synthesis of thieno[2,3-c]pyridine and 2-substituted thieno[2,3-c]pyridines. Synthesis, (12), 1935-1937. doi:10.1055/s-2004-829134 Peer reviewed |
 | Dupont, L., & Liégeois, J.-F. (2004). Crystal structure of bis(8-chloro-5-(4-methylpiperazinium-1-yl)pyrido[2,3-b][1,5]benzoxazepine) fumarate-fumaric acid solvate (1 : 1), (C17H18ClN4O)(2)(C4H2O4)center dot C4H4O4. Zeitschrift für Kristallographie. New Crystal Structures, 219 (2), 147-149. Peer Reviewed verified by ORBi |
 | Dupont, L., & Liégeois, J.-F. (December 2003). 8-Chloro-5-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,5]benzoxazepine. Acta Crystallographica. Section E, Structure Reports Online, 59 (Part 12), 1962-O1963. doi:10.1107/S1600536803025844 Peer Reviewed verified by ORBi |
 | Spirlet, M.-R., Graulich, A., & Liégeois, J.-F. (December 2003). 8-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine. Acta Crystallographica. Section E, Structure Reports Online, 59 (Part 12), 1990-O1991. doi:10.1107/S1600536803026448 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Mercier, F., Graulich, A., Graulich-Lorge, F., Scuvée-Moreau, J., & Seutin, V. (2003). Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry. Current Medicinal Chemistry, 10 (8), 625-47. doi:10.2174/0929867033457908 Peer Reviewed verified by ORBi |
 | Ellenbroek, B. A., & Liégeois, J.-F. (2003). JL 13, an atypical antipsychotic: A preclinical review [letter to the editor]. CNS Drug Reviews, 9 (1, Spring), 41-56. doi:10.1111/j.1527-3458.2003.tb00243.x Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Eyrolles, L., Ellenbroek, B. A., Lejeune, C., Carato, P., Bruhwyler, J., Geczy, J., Damas, J., & Delarge, J. (07 November 2002). New pyridobenzodiazepine derivatives: Modifications of the basic side chain differentially modulate binding to dopamine (D-4.2, D-2L) and serotonin (5-HT2A) receptors. Journal of Medicinal Chemistry, 45 (23), 5136-5149. doi:10.1021/jm0104825 Peer Reviewed verified by ORBi |
 | Scuvée-Moreau, J., Liégeois, J.-F., Massotte, L., & Seutin, V. (September 2002). Methyl-laudanosine: A new pharmacological tool to investigate the function of small-conductance Ca2+-activated K+ channels. Journal of Pharmacology and Experimental Therapeutics, 302 (3), 1176-1183. doi:10.1124/jpet.302.3.1176 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Ichikawa, J., & Meltzer, H. Y. (30 August 2002). 5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. Brain Research, 947 (2), 157-165. doi:10.1016/S0006-8993(02)02620-3 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Bruhwyler, J., Hendrick, J. C., Delarge, J., Legros, J.-J., & Damas, J. (February 2002). Minimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats. Neuroscience Letters, 319 (1), 49-52. doi:10.1016/S0304-3940(01)02539-3 Peer Reviewed verified by ORBi |
Liégeois, J.-F. (2002). La clozapine, source d'inspiration pour les pharmacochimistes, les pharmacologues et les psychopharmacologues [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/79585 |
 | Dupont, L., Eyrolles, L., Evrard, G., Delarge, J., & Liégeois, J.-F. (January 2002). 8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine. Acta Crystallographica. Section E, Structure Reports Online, 58 (Part 1), 69-O71. doi:10.1107/S1600536801021286 Peer Reviewed verified by ORBi |
 | Damas, J., Garbacki, N., Liégeois, J.-F., & Juchmes, J. (December 2001). Le controle du reseau vasculaire cutane. Revue Médicale de Liège, 56 (12), 846-9. Peer reviewed |
 | Mouithys-Mickalad, A., Kauffmann, J. M., Petit, C., Bruhwyler, J., Liao, Y., Wikstrom, H., Damas, J., Delarge, J., Deby-Dupont, G., Geczy, J., & Liégeois, J.-F. (01 March 2001). Electrooxidation Potential as a Tool in the Early Screening for New Safer Clozapine-Like Analogues. Journal of Medicinal Chemistry, 44 (5), 769-76. doi:10.1021/jm000221f Peer Reviewed verified by ORBi |
Damas, J., Garbacki, N., Delarge, J., & Liégeois, J.-F. (2001). Inhibition by JL3 of some effects of histamine and of the anaphylactoid reactions induced by dextran in rats [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gent, Belgium. |
Liégeois, J.-F., Ichikawa, J., & Meltzer, H. Y. (2001). Scopolamine reduces clozapine-induced dopamine release in rat striatum. In W. T. O'Connor, J. P. Lowry, O'Connor, ... R. D. O'Neill (Eds.), Monitoring Molecules in Neuroscience - Proceedings of the 9th International Conference on In Vivo Methods (pp. 267-269). Dublin, Ireland: University College Dublin. Peer reviewed |
 | Rogister, F., Laeckmann, D., Plasman, P.-O., Van Eylen, F., Ghyoot, M., Maggetto, C., Liégeois, J.-F., Géczy, J., Herchuelz, A., Delarge, J., & Masereel, B. (2001). Novel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives. European Journal of Medicinal Chemistry, 36, 597-614. doi:10.1016/S0223-5234(01)01247-8 Peer Reviewed verified by ORBi |
Damas, J., & Liégeois, J.-F. (2001). About the relationship between the kallikrein-kinin system and insulin. Current Topics in Peptide and Protein Research, 4, 89-96. Peer reviewed |
 | Alvarez, C, Van Hees, T., Piel, G., Liégeois, J.-F., Evrard, B., Torrado, J.J, & Delattre, L. (2001). Préparation de complexes mebendazole-HPβCD à l'aide de polymères solubles dans l'eau et d'acides organiques. Annales Pharmaceutiques Françaises, 59, 380. Peer Reviewed verified by ORBi |
 | Ellenbroek, B., Liégeois, J.-F., Bruhwyler, J., & Cools, A. (2001). The effects of JL 13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia. Journal of Pharmacology and Experimental Therapeutics, 298, 386-391. Peer Reviewed verified by ORBi |
 | Casey, D., Bruhwyler, J., Delarge, J., Géczy, J., & Liégeois, J.-F. (2001). The behavioral effects of acute and chronic JL 13, a putative antipsychotic, in Cebus non-human primates. Psychopharmacology, 157, 228-235. doi:10.1007/s002130100808 Peer Reviewed verified by ORBi |
Alvarez, C., Van Hees, T., Piel, G., Liégeois, J.-F., Delattre, L., & Evrard, B. (2001). Preparation of mebendazole HP-beta-cyclodextrin complexes using water-soluble polymers and organic acids. STP Pharma Sciences, 11 (6), 439-442. Peer reviewed |
Alvarez, C., Van Hees, T., Piel, G., Liégeois, J.-F., Evrard, B., Torrado, J., & Delattre, L. (December 2000). Préparation de complexes mébendazole-HPbCD à l'aide de polymères solubles dans l'eau et d'acides organiques [Paper presentation]. 4ème Journée du Club français des Cyclodextrines, Grenoble, France. |
Alvarez, C., Van Hees, T., Piel, G., Liégeois, J.-F., Evrard, B., Torrado, J., & Delattre, L. (April 2000). Preparation of mebendazole HP-b-cyclodextrin complexes using water soluble polymers and organic acids [Paper presentation]. IXth Forum of Pharmaceutical Sciences, Blankenberge, Belgium. |
 | Liégeois, J.-F., Zahid, N., Bruhwyler, J., & Uetrecht, J. (March 2000). Hypochlorous Acid, a Major Oxidant Produced by Activated Neutrophils, Has Low Effect on Two Pyridobenzazepine Derivatives, Jl 3 and Jl 13. Archiv der Pharmazie, 333 (2-3), 63-7. doi:10.1002/(SICI)1521-4184(200002)333:2/3<63::AID-ARDP63>3.0.CO;2-C Peer reviewed |
 | Géczy, J., Bruhwyler, J., Scuvée-Moreau, J., Seutin, V., Masset, H., Heugen, Dresse, A., Lejeune, C., Decamp, E., Szente, L., Szejtli, J., & Liégeois, J.-F. (2000). The inclusion of fluoxetine into gamma-cyclodextrine increases its bioavailability: behavioural, electrophysiological and pharmacokinetics studies. Psychopharmacology, 151, 328-334. Peer Reviewed verified by ORBi |
De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium. |
De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M. H., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l’Alleud, Belgium. |
 | Liégeois, J.-F., Bruhwyler, J., Petit, C., Damas, J., Delarge, J., Geczy, J., Kauffmann, J. M., Lamy, M., Meltzer, H., & Mouithys-Mickalad, A. (01 October 1999). Oxidation Sensitivity May Be a Useful Tool for the Detection of the Hematotoxic Potential of Newly Developed Molecules: Application to Antipsychotic Drugs. Archives of Biochemistry and Biophysics, 370 (1), 126-37. doi:10.1006/abbi.1999.1380 Peer Reviewed verified by ORBi |
 | Damas, J., & Liégeois, J.-F. (March 1999). The Inflammatory Reaction Induced by Formalin in the Rat Paw. Naunyn-Schmiedeberg's Archives of Pharmacology, 359 (3), 220-7. doi:10.1007/PL00005345 Peer Reviewed verified by ORBi |
 | De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1999). Effective resolution of racemic pirlindole at the preparative scale. Chirality, 11, 261-266. doi:10.1002/(SICI)1520-636X(1999)11:4<261::AID-CHIR1>3.0.CO;2-S Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Seutin, V., Scuvée-Moreau, J., Dresse, A., Bruhwyler, J., Geczy, J., Delarge, J., & Damas, J. (1999). Influence of JL3, a potential antidepressant, on rat noradrenergic and serotonergic systems. European Journal of Pharmacology, 386, 211-216. doi:10.1016/S0014-2999(99)00777-3 Peer Reviewed verified by ORBi |
 | Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (December 1998). Enantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases. Journal of Pharmaceutical and Biomedical Analysis, 18 (4-5), 605-14. doi:10.1016/S0731-7085(98)00213-1 Peer Reviewed verified by ORBi |
 | Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (01 September 1998). Simultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 17 (6-7), 1071-9. doi:10.1016/S0731-7085(98)00073-9 Peer Reviewed verified by ORBi |
De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Effective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry. |
De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy. |
De Tullio, P., Ceccato, A., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (16 January 1998). Séparation énantiomérique du pirlindole à l’échelle préparative [Poster presentation]. Journées Jeunes Chercheurs, Paris, France. |
De Tullio, P., Felikidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindol, journées franco-belges de pharmacochimie. Journal de Pharmacie de Belgique, 53, 55. Peer Reviewed verified by ORBi |
Pirotte, B., De Tullio, P., Stachow, M., Felikidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindol. Journal de Pharmacie de Belgique, 53, 60. Peer Reviewed verified by ORBi |
Bruhwyler, J., Liégeois, J.-F., Gerardy, J., Damas, J., Chleide, E., Lejeune, C., Decamp, E., De Tullio, P., Delarge, J., Dresse, A., & Geczy, J. (1998). Comparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques. Behavioural Pharmacology, 9 (8), 731-7. doi:10.1097/00008877-199812000-00008 Peer Reviewed verified by ORBi |
Petit, C., Quilinc, A., Quilinc, E., Ortiz Borondo, G., Liégeois, J.-F., & Kauffmann, J.-M. (1998). Horseradish peroxidase electrode for phenothiazine analysis. Electroanalysis, 10, 1241-1248. doi:10.1002/(SICI)1521-4109(199812)10:18<1241::AID-ELAN1241>3.0.CO;2-Q Peer Reviewed verified by ORBi |
Liégeois, J.-F., Eyrolles, L., Bruhwyler, J., & Delarge, J. (1998). Dopamine D4 receptors, a new opportunity for research on schizophrenia. Current Medicinal Chemistry, 5, 77-100. Peer Reviewed verified by ORBi |
De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration. European Journal of Pharmaceutical Sciences, suppl.1, 37. Peer Reviewed verified by ORBi |
 | De Tullio, P., Felekidis, A., Pirotte, B., Liégeois, J.-F., Stachow, M., Delarge, J., Ceccato, A., Hubert, P., Crommen, J., & Geczy, J. (1998). First preparative enantiomer resolution of pirlindole, a potent antidepressant drug. Helvetica Chimica Acta, 81, 539-547. doi:10.1002/hlca.19980810307 Peer Reviewed verified by ORBi |
Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole. Journal de Pharmacie de Belgique, 53, 60. Peer Reviewed verified by ORBi |
De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindole. Journal de Pharmacie de Belgique, 53, 55. Peer Reviewed verified by ORBi |
 | Bruhwyler, J., Liégeois, J.-F., & Geczy, J. (1998). Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 22 (1), 115-28. doi:10.1016/S0278-5846(97)00183-8 Peer Reviewed verified by ORBi |
Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (1998). Determination of the enantiomeric purity of pirlindole by liquid chromatography using a cellulose based chiral stationary phase. Journal de Pharmacie de Belgique, 53, 169. Peer Reviewed verified by ORBi |
Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (1998). Liquid chromatographic separation of pirlindole enantiomers using different types of chiral stationary phases. Journal de Pharmacie de Belgique, 53, 168. Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Mouithys-Mickalad, A., Bruhwyler, J., Delarge, J., Petit, C., Kauffmann, J. M., & Lamy, M. (08 September 1997). Jl 13, a Potential Successor to Clozapine, Is Less Sensitive to Oxidative Phenomena. Biochemical and Biophysical Research Communications, 238 (1), 252-5. doi:10.1006/bbrc.1997.7270 Peer reviewed |
Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (September 1997). Simultaneous determination of pirlindole enantiomers and dehydropirlindole by liquid chromatography using a cellulose based chiral stationary phase [Poster presentation]. 7th Meeting on Recent Developments in Pharmaceutical Analysis, Ile d'Elbe, Italy. |
De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Cegzy, J., & Delarge, J. (May 1997). Résolution préparative du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium. |
 | Damas, J., Liégeois, J.-F., & Bourdon, V. (May 1997). Involvement of 5-Hydroxytryptamine and Bradykinin in the Hyperalgesia Induced in Rats by Collagenase from Clostridium Histolyticum. Naunyn-Schmiedeberg's Archives of Pharmacology, 355 (5), 566-70. doi:10.1007/PL00004984 Peer Reviewed verified by ORBi |
Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (May 1997). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium. |
Damas, J., & Liégeois, J.-F. (March 1997). La famille des peptides natriurétiques. Revue Médicale de Liège, 52 (3), 169-73. Peer reviewed |
Liégeois, J.-F., & Bruhwyler, J. (1997). Dopamine D4 selective ligands as potential antipsychotics. In F. Awouters (Ed.), Proceedings of the XIVth International Symposium on Medicinal Chemistry (pp. 271-290). Peer reviewed |
 | Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., Bregadze, V. I., Dolgushin, F. M., Yanovsky, A. I., & Struchkov, Y. T. (1997). Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes. Molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-Rh C2B9H11]. Journal of Organometallic Chemistry, 536-537, 405-412. doi:10.1016/S0022-328X(96)06743-5 Peer Reviewed verified by ORBi |
 | Bruhwyler, J., Liégeois, J.-F., & Geczy, J. (1997). Pirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties. Pharmacological Research, 36 (1), 23-33. doi:10.1006/phrs.1997.0196 Peer Reviewed verified by ORBi |
 | Bruhwyler, J., Liégeois, J.-F., Bergman, J., Carey, G., Goudie, A., Taylor, A., Meltzer, H. Y., Delarge, J., & Géczy, J. (1997). JL 13, a pyridobenzoxazepine compound with potential atypical antipsychotic activity: a review of its behavioral properties. Pharmacological Research, 36, 255-264. doi:10.1006/phrs.1997.0231 Peer Reviewed verified by ORBi |
Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (1997). Enantiomeric separation of pirlindole enantiomers and dehydroprilindole by chrial liquid chromatography [Poster presentation]. VIIth meeting on recent developments in pharmaceutical analysis. |
 | Damas, J., Bourdon, V., Liégeois, J.-F., & Simmons, W. H. (November 1996). Influence of Several Peptidase Inhibitors on the Pro-Inflammatory Effects of Substance P, Capsaicin and Collagenase. Naunyn-Schmiedeberg's Archives of Pharmacology, 354 (5), 662-9. doi:10.1007/BF00170843 Peer Reviewed verified by ORBi |
 | Damas, J., Liégeois, J.-F., & Simmons, W. H. (November 1996). Potentiation of the Pro-Inflammatory Effects of Bradykinin by Inhibition of Angiotensin-Converting Enzyme and Aminopeptidase P in Rat Paws. Naunyn-Schmiedeberg's Archives of Pharmacology, 354 (5), 670-6. doi:10.1007/BF00170844 Peer Reviewed verified by ORBi |
Dupont, L., Liégeois, J.-F., Rogister, F., & Delarge, J. (1996). 8-Chloro-5-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,5]benzodiazepine. Acta Crystallographica. Section C, Crystal Structure Communications, C52, 391-393. doi:10.1107/S0108270195011942 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Scuvée-Moreau, J., Giesbers, I., Damas, J., Bruhwyler, J., Geczy, J., Delarge, J., & Dresse, A. (1996). Dibenzoazepine analogues : the electrophysiological properties of JL3, a potential atypical antidepressant. European Journal of Pharmacology, 310, 9-12. doi:10.1016/0014-2999(96)00361-5 Peer Reviewed verified by ORBi |
Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (1996). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas. Journal de Pharmacie de Belgique, 51, 17. Peer Reviewed verified by ORBi |
Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (June 1995). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France. |
Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (June 1995). Synthesis and diuretic properties of pyrid-3-ylsulfonylcyanoguanidines [Poster presentation]. 31èmes Rencontres Internationales de Chimie Thérapeutique, Lyon, France. |
Liégeois, J.-F., Rogister, F., Delarge, J., & Pincemail, J. (February 1995). Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives. Archiv der Pharmazie, 328 (2), 109-12. doi:10.1002/ardp.19953280203 Peer reviewed |
Bruhwyler, J., Liégeois, J.-F., Lejeune, C., Rogister, F., Delarge, J., & Geczy, J. (1995). New dibenzazepine derivatives with disinhibitory and/or antidepressant potential: neurochemical and behavioural study in the open-field and forced swimming tests. Behavioural Pharmacology, 6 (8), 830-838. Peer Reviewed verified by ORBi |
Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., & Bregadze, V. I. (1995). Influence de la nature des ligands sur l'hydrogenation de la méthacycline en doxycycline et en épi-doxycycline par des complexes du Rhodium. Journal de Pharmacie de Belgique, 50, 232. Peer Reviewed verified by ORBi |
Dupont, L., Liégeois, J.-F., Rogister, F., & Delarge, J. (1995). 3-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine. Acta Crystallographica. Section C, Crystal Structure Communications, C51, 1889-1891. doi:10.1107/S0108270195003337 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Bonaventure, P., Delarge, J., & Damas, J. (1995). Antipsychotics and Neuropeptides: The Atypical Profile of Ci-943 and Its Relationship to Neurotensin. Neuroscience and Biobehavioral Reviews, 19 (4, Winter), 519-31. doi:10.1016/0149-7634(95)00016-X Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Bruhwyler, J., Damas, J., Rogister, F., Masereel, B., Geczy, J., & Delarge, J. (1995). Modulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 Receptor. European Journal of Pharmacology, 273 (3), 1-3. doi:10.1016/0014-2999(94)00782-3 Peer Reviewed verified by ORBi |
 | Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (1995). Synthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics. European Journal of Medicinal Chemistry, 30, 343-351. doi:10.1016/0223-5234(96)88244-4 Peer Reviewed verified by ORBi |
Dupont, L., Liégeois, J.-F., Rogister, F., & Delarge, J. (1995). 11-(4-methylpiperazin-1-yl)-5H-pyrido[4,3-b][1,5]benzodiazepine. Acta Crystallographica. Section C, Crystal Structure Communications, C51, 1379-1381. doi:10.1107/S0108270194014459 Peer Reviewed verified by ORBi |
Liégeois, J.-F., Bruhwyler, J., Rogister, F., & Delarge, J. (1995). Diarylazepine derivatives as potent atypical neuroleptic drugs: Recent advances. Current Medicinal Chemistry, 1, 471-501. Peer Reviewed verified by ORBi |
Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., & Bregadze, V. I. (May 1994). Influence de la nature des ligands sur l'hydrogénation de la méthacycline en doxycycline et en épi-doxycycline par des complexes du Rhodium [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium. |
 | Liégeois, J.-F., Rogister, F. A., Bruhwyler, J., Damas, J., Nguyen, T. P., Inarejos, M. O., Chleide, E. M., Mercier, M. G., & Delarge, J. E. (10 February 1994). Pyridobenzoxazepine and Pyridobenzothiazepine Derivatives as Potential Central Nervous System Agents: Synthesis and Neurochemical Study. Journal of Medicinal Chemistry, 37 (4), 519-25. doi:10.1021/jm00030a011 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Bruhwyler, J., Damas, J., Nguyen, T. P., Chleide, E. M., Mercier, M. G., Rogister, F. A., & Delarge, J. E. (23 July 1993). New Pyridobenzodiazepine Derivatives as Potential Antipsychotics: Synthesis and Neurochemical Study. Journal of Medicinal Chemistry, 36 (15), 2107-14. doi:10.1021/jm00067a009 Peer Reviewed verified by ORBi |
Liégeois, J.-F., & Damas, J. (01 July 1993). Un messager intercellulaire original, le NO (monoxyde d'azote). Revue Médicale de Liège, 48 (7), 406-13. Peer reviewed |
Bruhwyler, J., Chleide, E., Liégeois, J.-F., & Carreer, F. (1993). Nitric oxide: a new messenger in the brain. Neuroscience and Biobehavioral Reviews, 17 (4), 373-84. doi:10.1016/S0149-7634(05)80114-9 Peer Reviewed verified by ORBi |
Liégeois, J.-F. (1992). Etudes pharmacochimiques et pharmacologiques dans la série des azaarylazépines [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/79584 |
Liégeois, J.-F., Dupont, L., & Delarge, J. (1992). Application de l'analyse CoMFA (Comparative Molecular Field Analysis) à une série de dérivés tricycliques apparentés à la clozapine. Journal de Pharmacie de Belgique, 47, 100-108. Peer Reviewed verified by ORBi |
Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1992). Structure du 8-chloro-11-(méthylpipérazin-1-yl)dibenzo[b,f]-1,4-thiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C48, 1851-1853. doi:10.1107/S0108270192001021 Peer Reviewed verified by ORBi |
Dupont, L., Englebert, S., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1992). Structure du 6-(4-méthylpipérazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazépine 1,5-hydrate. Acta Crystallographica. Section C, Crystal Structure Communications, C48, 1322-1324. doi:10.1107/S0108270191013744 Peer Reviewed verified by ORBi |
Bruhwyler, J., Liégeois, J.-F., Chleide, E., Rogister, F., Damas, J., Delarge, J., & Mercier, M. (1992). Comparative study of typical neuroleptics, clozapine and newly synthesized clozapine-analogues: correlations between neurochemistry and behaviour. Behavioural Pharmacology, 3 (6), 567-579. Peer Reviewed verified by ORBi |
Dupont, L., Englebert, S., Dideberg, O., Liégeois, J.-F., & delarge, J. (1991). Structures du 11-formyl-5-(4-méthylpipérazin-1-yl)-11H-pyrido[2,3b][1,5]benzodiazépine et du 6-(4-méthylpipérazin-1-yl)-11-méthyl-11H-pyrido[2,3-b][1,4]benzodiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C47, 2690-2693. Peer Reviewed verified by ORBi |
Bruhwyler, J., Chleide, E., Liégeois, J.-F., Delarge, J., & Mercier, M. (1991). Effects of specific dopaminergic agonists and antagonists in the open-field test. Pharmacology, Biochemistry and Behavior, 39 (2), 367-71. doi:10.1016/0091-3057(91)90193-6 Peer Reviewed verified by ORBi |
Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1991). Structure du méthyl-4 pipérazinyl-1)-10 pyrido[4,3-b][1,4]benzothiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C47, 1740-1742. doi:10.1107/S0108270191001191 Peer Reviewed verified by ORBi |
 | Liégeois, J.-F., Dive, G., Dupont, L., & Delarge, J. (1991). New alkoxypyridine Sulfonamides: Synthesis, Biological Evaluation and Physicochemical Properties. Helvetica Chimica Acta, 74 (8), 1764-1772. doi:10.1002/hlca.19910740819 Peer Reviewed verified by ORBi |
Bruhwyler, J., Chleide, E., Liégeois, J.-F., Delarge, J., & Mercier, M. (1990). Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test. Pharmacology, Biochemistry and Behavior, 36 (1), 57-61. doi:10.1016/0091-3057(90)90125-2 Peer Reviewed verified by ORBi |
Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1990). Structure du N-diméthylaminoéthyl Méthoxy-4 Pyridinesulfonamide-3 et du N-[(éthyl-1pyrrolidinyl-2) méthyl] Pyridinesulfonamide-3. Acta Crystallographica. Section C, Crystal Structure Communications, C46, 1863-1866. Peer Reviewed verified by ORBi |
Liégeois, J.-F. (1990). Contribution à l'étude des relations structure-activité parmi les antipsychotiques atypiques : synthèse et évaluation pharmacologique de pyridobenzoazépines bioisostères de la clozapine [Specialised master, ULille - Université de Lille]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/79583 |
Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1988). Structure du (Méthyl-1-pipérazinyl-4)-5 Pyrido[2,3-b][1,5]benzothiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C44, 319-321. doi:10.1107/S0108270187010151 Peer Reviewed verified by ORBi |
Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1988). Structure du N-diéthylaminoéthyl méthoxy-4 pyridine sulfonamide-3. Acta Crystallographica. Section C, Crystal Structure Communications, C44, 907-909. doi:10.1107/S010827018800099X Peer Reviewed verified by ORBi |
Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1987). Structure du maléate de (pyrido[2,3-b]benzo-1,5-oxazépinyl-11)-4-méthyl-1H+-pipérazinium, C17H19N4OH + C4H3O4. Acta Crystallographica. Section C, Crystal Structure Communications, C43, 716-718. Peer Reviewed verified by ORBi |
Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1987). Structure de l'acide diphénylamino-2 carboxylique. Acta Crystallographica. Section C, Crystal Structure Communications, C43, 926-928. Peer Reviewed verified by ORBi |
 | Wittner, M., Di Stefano, A., Wangemann, P., Delarge, J., Liégeois, J.-F., & Greger, R. (1987). Analogues of torasemide--structure function relationships--experiments in the thick ascending limb of the loop of Henle of rabbit nephron. Pflügers Archiv: European Journal of Physiology, 408 (1), 54-62. doi:10.1007/BF00581840 Peer Reviewed verified by ORBi |
Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1987). Structure de la clothiapine. Acta Crystallographica. Section C, Crystal Structure Communications, C43, 720-722. doi:10.1107/S010827018709437X Peer Reviewed verified by ORBi |