Impact of antenatal exposure to a mixture of endocrine disruptors on attentional and executive functions in children.

[en] [en] CONTEXT: Numerous studies indicate negative associations between early life exposure to endocrine-disrupting chemicals and various aspects of neurodevelopment. However, few have focused on specific cognitive processes. Additionally, toxicants are often analyzed individually, without accounting for their combined effects. OBJECTIVE: This study aimed at investigating the impact of prenatal exposure to a mixture of endocrine disruptors on attention and executive functions in young children and comparing their effects with those reported in the literature. METHODS: Two polychlorinated biphenyls (PCBs) and 4 perfluoroalkyl substances (PFASs) were measured in the cord blood from 55 children enrolled in a longitudinal Belgian cohort study. At 6 years of age, attentional and executive functions were assessed using specific neuropsychological tests. Associations between a mixture of toxicants and cognitive performance were analyzed using the principal components approach and weighted quantile sum regression, while accounting for sex differences. RESULTS: Higher prenatal exposure to PCB mixtures was significantly associated with an increased number of omissions in the Divided Attention test. In sex-stratified analyses, this association remained significant but was observed only in boys. Additionally, boys exhibited reduced working memory and planning abilities following exposure to a mixture of PCBs and PFASs. In contrast, antenatal exposure to a mixture of PCBs and PFASs in girls was associated with reduced behavioral regulation, including inhibition control, as assessed by parent-reported questionnaires screening executive functioning in daily life. CONCLUSION: These results support associations between antenatal exposure to a mixture of endocrine disruptors and attention and executive development, emphasizing a sex-specific effect.

Disciplines :

Pediatrics

Author, co-author :

Barrea, Christophe ; Université de Liège - ULiège > Département des sciences cliniques > Médecine générale

Dufour, Patrice ; Centre Hospitalier Universitaire de Liège - CHU > > Service de toxicologie clinique, médicolégale, environnementale et en entreprise

Pirard, Catherine ; Université de Liège - ULiège > Département des sciences de la santé publique

Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique

Brevers, Fanny ; Université de Liège - ULiège > Département de Psychologie > Psychologie du développement cognitif normal et atypique

Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Rousselle, Laurence ; Université de Liège - ULiège > Département de Psychologie > Psychologie du développement cognitif normal et atypique

Language :

English

Title :

Impact of antenatal exposure to a mixture of endocrine disruptors on attentional and executive functions in children.

Publication date :

April 2026

Journal title :

Journal of the Endocrine Society

eISSN :

2472-1972

Publisher :

The Endocrine Society, United States

Volume :

Issue :

Pages :

bvag057

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvag057/67385638/bvag057.pdf

Funders :

Leon Fredericq Foundation

Available on ORBi :

since 02 May 2026

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