Genetic Determinants Of Bovine Leukemia Virus Pathogenesis

Animals; Cattle; Cattle Diseases/physiopathology/virology; Enzootic Bovine Leukosis/genetics/virology; Leukemia Virus, Bovine/genetics/pathogenicity; Sheep; Sheep Diseases/physiopathology/virology

Abstract :

[en] The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Willems, Luc ; Université de Liège - ULiège > GIGA-Research

Burny, Arsène ; Université de Liège - ULiège > Agro Biotech Gembloux

Collete, Delphine

Dangoisse, Olivier

Dequiedt, Franck ; Université de Liège - ULiège > GIGA-Research

GATOT, Jean-Stéphane

Kerkhofs, Pierre

Lefebvre, Laurent

Merezak, C.

Peremans, T.

More authors (3 more)

Language :

English

Title :

Genetic Determinants Of Bovine Leukemia Virus Pathogenesis

Publication date :

2000

Journal title :

AIDS Research and Human Retroviruses

ISSN :

0889-2229

eISSN :

1931-8405

Publisher :

Mary Ann Liebert, Larchmont, United States - New York

Volume :

Issue :

Pages :

1787-95

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 March 2011

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