Reference : Genetic Determinants Of Bovine Leukemia Virus Pathogenesis
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Genetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc mailto [Université de Liège - ULiège > > GIGA-Research >]
Burny, A. [> > > >]
Collete, Delphine [> > > >]
Dangoisse, O. [> > > >]
Dequiedt, Franck mailto [Université de Liège - ULiège > > GIGA-Research >]
GATOT, Jean-Stéphane mailto [> > > >]
Kerkhofs, P. [> > > >]
Lefebvre, L. [> > > >]
Merezak, C. [> > > >]
Peremans, T. [> > > >]
Portetelle, Daniel mailto [Université de Liège - ULiège > > Gembloux Agro-Bio Tech >]
Twizere, Jean-Claude mailto [Université de Liège - ULiège > > Gembloux Agro-Bio Tech >]
Kettmann, Richard mailto [Université de Liège - ULiège > > Gembloux Agro-Bio Tech >]
Aids Research and Human Retroviruses
Mary Ann Liebert
Yes (verified by ORBi)
[en] Animals ; Cattle ; Cattle Diseases/physiopathology/virology ; Enzootic Bovine Leukosis/genetics/virology ; Leukemia Virus, Bovine/genetics/pathogenicity ; Sheep ; Sheep Diseases/physiopathology/virology
[en] The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep.

File(s) associated to this reference

Fulltext file(s):

Restricted access
pa039561.pdfNo commentaryPublisher postprint250.79 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.