organogenic totipotency; neoplastic progression; habituation; hyperhydricity; oxidative stress; plant cancer
Abstract :
[en] The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under different circumstances: genetic variation in the cell population, epigenetic changes, disappearance of an organogenesis-promoting substance, etc. The same reasons may be evoked for the progressive and eventually irreversible loss of organogenic totipotency in the course of neoplastic progressions from hormone-independent tumors and hyperhydric teratomas to cancers. As in animal cells, plant cells at the end of a neoplastic progression have probably undergone several independent genetic accidents with cumulative effects. They indeed are characterized by atypical biochemical cycles from which they are apparently unable to escape. The metabolic changes are probably not the primary defects that cause cancer, rather they may allow the cells to survive. How these changes, namely an oxidative stress, affect organogenesis is not known. The literature focuses on somatic mutations and epigenetic changes that cause aberrant regulation of cell cycle genes and their machinery.
Kevers, Claire ; Université de Liège - ULiège > Département des sciences de la vie > Biologie moléculaire et biotechnologie végétales
Bisbis, Badia; Université de Liège - ULiège > Hormonologie végétale
Franck, Thierry ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Crèvecoeur, Michèle; Université de Genève - UNIGE > Physiologie et Biochimie Végétales
Greppin, Hubert; Université de Genève - UNIGE > Physiologie et Biochimie Végétales
Dommes, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > Biologie moléculaire et biotechnologie végétales
Language :
English
Title :
Loss of plant organogenic totipotency in the course of in vitro neoplastic progression
Publication date :
2000
Journal title :
In Vitro Cellular and Developmental Biology. Plant
ISSN :
1054-5476
eISSN :
1475-2689
Publisher :
Springer Science & Business Media B.V., Wallingford, United Kingdom
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