[en] Phytochemical investigations of the trunk bark extract of Funtumia elastica (Preuss) Stapf, afforded a new ceramide namely, funtulaticamide (1) along with six known compounds: funtulatine (2), methyl ursolate (3), epicatechin (4), myricetin (5), sucrose (6) and 5-hydroxypyridine-3-carboxamide (7). Their structures were determined on the basis of various spectroscopic and chemical methods, as well as comparison with literature. Compounds were mostly isolated for the first time from this plant, and no evidence could be found on a previous report of a phytosphingosine-type ceramide in the genus Funtumia. Similarly, compound 7 is isolated from the Apocynaceae family for the first time. Hence, the chemophenetic significance of isolates was briefly introduced. In addition, compound 2 exhibited a moderate activity against Leishmania donovani 1S (MHOM/SD/62/1S) with an IC 50 value of 15.9 μM.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Kom Ma'mag, Larissa; Faculty of Science, Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon ; Center for Studies on Medicinal Plants and Traditional Medicine (CRPMT), Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon
Abouem, Auguste
Zintchem, A; Faculty of Science, Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon ; Department of Chemistry, Higher Teacher's Training College, University of Yaounde 1, Yaounde, Cameroon
Tchinda, Alembert; Center for Studies on Medicinal Plants and Traditional Medicine (CRPMT), Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon ; Natural and Synthetic Drugs Research Center, Laboratory of Pharmacognosy, University of Liege, Liege, Belgium
Kopa Kowa, Théodora; Center for Studies on Medicinal Plants and Traditional Medicine (CRPMT), Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon ; Natural and Synthetic Drugs Research Center, Laboratory of Pharmacognosy, University of Liege, Liege, Belgium
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Ngono Bikobo, Dominique; Faculty of Science, Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon
Pegnyemb, Emmanuel; Faculty of Science, Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon
Language :
English
Title :
Funtulaticamide, a phytosphingosine-type ceramide from Funtumia elastica Preuss Stapf. (Apocynaceae) trunk bark with potential antileishmanial activity
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