[en] Microbial exopolysaccharides (EPSs) are receiving growing interest today, owing to their diversity in chemical structure and source, multiple functions, and immense potential applications in many food and non-food industries. Their health-promoting benefits for humans deserve particular attention because of their various biological activities and physiological functions. The aim of this paper is to provide a comprehensive review of microbial EPSs, covering (1) their chemical and biochemical diversity, including composition, biosynthesis, and bacterial sources belonging mainly to lactic acid bacteria (LAB) or probiotics; (2) their technological and analytical aspects, especially their production mode and characterization; (3) their biological and physiological aspects based on their activities and functions; and (4) their current and future uses in medical and pharmaceutical fields, particularly for their prebiotic, anticancer, and immunobiotic properties, as well as their applications in other industrial and agricultural sectors.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Nguyen, Huu-Thanh ; Department of Biotechnology, An Giang University, Vietnam National University, 18 Ung Van Khiem, Long Xuyen City 880000, Vietnam ; Vietnam National University Ho Chi Minh, Thu Duc City, HCM City 71308, Vietnam
Pham, Thuy-Trang ; Department of Biotechnology, An Giang University, Vietnam National University, 18 Ung Van Khiem, Long Xuyen City 880000, Vietnam ; Vietnam National University Ho Chi Minh, Thu Duc City, HCM City 71308, Vietnam
Nguyen, Phu-Tho; Department of Biotechnology, An Giang University, Vietnam National University, 18 Ung Van Khiem, Long Xuyen City 880000, Vietnam ; Vietnam National University Ho Chi Minh, Thu Duc City, HCM City 71308, Vietnam
Le-Buanec, Hélène; INSERM U976-HIPI Hôpital Saint Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France
Costa J.A.V. Lucas B.F. Alvarenga A.G.P. Moreira J.B. de Morais M.G. Microalgae Polysaccharides: An Overview of Production, Characterization, and Potential Applications Polysaccharides 2021 2 759 772 10.3390/polysaccharides2040046
Hamidi M. Okoro O.V. Milan P.B. Khalili M.R. Samadian H. Nie L. Shavandi A. Fungal Exopolysaccharides: Properties, Sources, Modifications, and Biomedical Applications Carbohydr. Polym. 2022 284 119152 10.1016/j.carbpol.2022.119152 35287892
Rahbar Saadat Y. Yari Khosroushahi A. Pourghassem Gargari B. Yeast Exopolysaccharides and Their Physiological Functions Folia Microbiol. 2021 66 171 182 10.1007/s12223-021-00856-2
Sørensen H.M. Rochfort K.D. Maye S. MacLeod G. Brabazon D. Loscher C. Freeland B. Exopolysaccharides of Lactic Acid Bacteria: Production, Purification and Health Benefits towards Functional Food Nutrients 2022 14 2938 10.3390/nu14142938 35889895
Rana S. Upadhyay L.S.B. Microbial Exopolysaccharides: Synthesis Pathways, Types and Their Commercial Applications Int. J. Biol. Macromol. 2020 157 577 583 10.1016/j.ijbiomac.2020.04.084
Branda S.S. Vik Å. Friedman L. Kolter R. Biofilms: The Matrix Revisited Trends Microbiol. 2005 13 20 26 10.1016/j.tim.2004.11.006
Xu Y. Cui Y. Yue F. Liu L. Shan Y. Liu B. Zhou Y. Lü X. Exopolysaccharides Produced by Lactic Acid Bacteria and Bifidobacteria: Structures, Physiochemical Functions and Applications in the Food Industry Food Hydrocoll. 2019 94 475 499 10.1016/j.foodhyd.2019.03.032
Lynch K.M. Zannini E. Coffey A. Arendt E.K. Lactic Acid Bacteria Exopolysaccharides in Foods and Beverages: Isolation, Properties, Characterization, and Health Benefits Annu. Rev. Food Sci. Technol. 2018 9 155 176 10.1146/annurev-food-030117-012537
Torino M.I. Font de Valdez G. Mozzi F. Biopolymers from Lactic Acid Bacteria. Novel Applications in Foods and Beverages Front. Microbiol. 2015 6 834 10.3389/fmicb.2015.00834
Andrew M. Jayaraman G. Structural Features of Microbial Exopolysaccharides in Relation to Their Antioxidant Activity Carbohydr. Res. 2020 487 107881 10.1016/j.carres.2019.107881
Moscovici M. Present and Future Medical Applications of Microbial Exopolysaccharides Front. Microbiol. 2015 6 1012 10.3389/fmicb.2015.01012 26483763
Rahbar Saadat Y. Yari Khosroushahi A. Pourghassem Gargari B. A Comprehensive Review of Anticancer, Immunomodulatory and Health Beneficial Effects of the Lactic Acid Bacteria Exopolysaccharides Carbohydr. Polym. 2019 217 79 89 10.1016/j.carbpol.2019.04.025 31079688
Amiri S. Rezaei Mokarram R. Sowti Khiabani M. Rezazadeh Bari M. Alizadeh Khaledabad M. Exopolysaccharides Production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12: Optimization of Fermentation Variables and Characterization of Structure and Bioactivities Int. J. Biol. Macromol. 2019 123 752 765 10.1016/j.ijbiomac.2018.11.084
Harutoshi T. Exopolysaccharides of Lactic Acid Bacteria for Food and Colon Health Applications Lactic Acid Bacteria-R & D for Food, Health and Livestock Purposes InTech London, UK 2013
Schmid J. Sieber V. Rehm B. Bacterial Exopolysaccharides: Biosynthesis Pathways and Engineering Strategies Front. Microbiol. 2015 6 496 10.3389/fmicb.2015.00496
Tan K.-X. Chamundeswari V.N. Loo S.C.J. Prospects of Kefiran as a Food-Derived Biopolymer for Agri-Food and Biomedical Applications RSC Adv. 2020 10 25339 25351 10.1039/D0RA02810J
Zeidan A.A. Poulsen V.K. Janzen T. Buldo P. Derkx P.M. Øregaard G. Neves A.R. Polysaccharide Production by Lactic Acid Bacteria: From Genes to Industrial Applications FEMS Microbiol. Rev. 2017 41 S168 S200 10.1093/femsre/fux017 28830087
Donot F. Fontana A. Baccou J.C. Schorr-Galindo S. Microbial Exopolysaccharides: Main Examples of Synthesis, Excretion, Genetics and Extraction Carbohydr. Polym. 2012 87 951 962 10.1016/j.carbpol.2011.08.083
Badel S. Bernardi T. Michaud P. New Perspectives for Lactobacilli Exopolysaccharides Biotechnol. Adv. 2011 29 54 66 10.1016/j.biotechadv.2010.08.011
Yates L.E. Mills D.C. DeLisa M.P. Bacterial glycoengineering as a biosynthetic route to customized glycomolecules Advances in Glycobiotechnology Rapp E. Reichl U. Springer International Publishing Cham, Switzerland 2021 167 200 978-3-030-69590-3
Sutherland I.W. Biosynthesis of microbial exopolysaccharides Advances in Microbial Physiology Elsevier Amsterdam, The Netherlands 1982 Volume 23 79 150 0065-2911
Singha T.K. Microbial Extracellular Polymeric Substances: Production, Isolation and Applications IOSR J. Pharm. 2012 2 271 281
Freitas F. Torres C.A. Reis M.A. Engineering Aspects of Microbial Exopolysaccharide Production Bioresour. Technol. 2017 245 1674 1683 10.1016/j.biortech.2017.05.092
Chaudhari V. Buttar H.S. Bagwe-Parab S. Tuli H.S. Vora A. Kaur G. Therapeutic and Industrial Applications of Curdlan with Overview on Its Recent Patents Front. Nutr. 2021 8 646988 10.3389/fnut.2021.646988 34262922
Mohd Nadzir M. Nurhayati R.W. Idris F.N. Nguyen M.H. Biomedical Applications of Bacterial Exopolysaccharides: A Review Polymers 2021 13 530 10.3390/polym13040530 33578978
Panchal R. Prajapati K. Prajapati M. Sharma S. Saraf M.S. Bacterial Exopolysaccharides: Types, Its Biosynthesis and Their Application in Different Fields Acta Sci. Biotechnol. 2022 3 1 9
Zhang P. Yuan L. Zeng J. Zou K. Liu B. Qing T. Feng B. Alginate Production of Pseudomonas Strains and Its Application in Preparation of Alginate-Biomass Hydrogel for Heavy Metal Adsorption Int. J. Biol. Macromol. 2022 222 1511 1521 10.1016/j.ijbiomac.2022.09.252 36183760
Benhadda F. Zykwinska A. Colliec-Jouault S. Sinquin C. Thollas B. Courtois A. Fuzzati N. Toribio A. Delbarre-Ladrat C. Marine versus Non-Marine Bacterial Exopolysaccharides and Their Skincare Applications Mar. Drugs 2023 21 582 10.3390/md21110582
Mummaleti G. Sarma C. Kalakandan S.K. Gazula H. Sivanandham V. Anandharaj A. Characterization of Levan Produced from Coconut Inflorescence Sap Using Bacillus Subtilis and Its Application as a Sweetener LWT 2022 154 112697 10.1016/j.lwt.2021.112697
Baptista S. Torres C.A.V. Sevrin C. Grandfils C. Reis M.A.M. Freitas F. Extraction of the Bacterial Extracellular Polysaccharide FucoPol by Membrane-Based Methods: Efficiency and Impact on Biopolymer Properties Polymers 2022 14 390 10.3390/polym14030390
Wünsche J. Schmid J. Acetobacteraceae as Exopolysaccharide Producers: Current State of Knowledge and Further Perspectives Front. Bioeng. Biotechnol. 2023 11 1166618 10.3389/fbioe.2023.1166618
Yang Y. Jiang G. Tian Y. Biological Activities and Applications of Exopolysaccharides Produced by Lactic Acid Bacteria: A Mini-Review World J. Microbiol. Biotechnol. 2023 39 155 10.1007/s11274-023-03610-7
Jurášková D. Ribeiro S.C. Silva C.C. Exopolysaccharides Produced by Lactic Acid Bacteria: From Biosynthesis to Health-Promoting Properties Foods 2022 11 156 10.3390/foods11020156
Balkrishna A. Agarwal V. Kumar G. Gupta A.K. Applications of Bacterial Polysaccharides with Special Reference to the Cosmetic Industry Microbial Bioprospecting for Sustainable Development Springer Singapore 2018 189 202
Jeong J. Kim Y. Hu Y. Jung S. Bacterial Succinoglycans: Structure, Physical Properties, and Applications Polymers 2022 14 276 10.3390/polym14020276 35054683
Huang H. Lin J. Wang W. Li S. Biopolymers Produced by Sphingomonas Strains and Their Potential Applications in Petroleum Production Polymers 2022 14 1920 10.3390/polym14091920 35567089
Serra M. Casas A. Toubarro D. Barros A.N. Teixeira J.A. Microbial Hyaluronic Acid Production: A Review Molecules 2023 28 2084 10.3390/molecules28052084
Chen C.C. Nargotra P. Kuo C.H. Liu Y.C. High-Molecular-Weight Exopolysaccharides Production from Tuber brochii Cultivated by Submerged Fermentation Int. J. Mol. Sci. 2023 24 4875 10.3390/ijms24054875
Santra H.K. Banerjee D. Production, Optimization, Characterization and Drought Stress Resistance by β-Glucan-Rich Heteropolysaccharide From an Endophytic Fungi Colletotrichum Alatae LCS1 Isolated From Clubmoss (Lycopodium clavatum) Front. Fungal Biol. 2021 2 796010 10.3389/ffunb.2021.796010
Chen J. Lu Y. Liu L. Bai R. Zhang S. Hao Y. Xu F. Wei B. Zhao H. Characteristic Analysis and Fermentation Optimization of a Novel Aureobasidium pullulans RM1603 with High Pullulan Yield J. Biosci. Bioeng. 2024 137 335 343 10.1016/j.jbiosc.2023.12.018
Shao Z. Tian Y. Liu S. Chu X. Mao W. Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29 Mar. Drugs 2023 21 270 10.3390/md21050270 37233464
Tao X. Chen X. Dong R. Wang G. Xu X. Yu Q. Chen Y. Wang X. Xie J. Characterization and Antioxidant Properties of Three Exopolysaccharides Produced by the Cyclocarya paliurus Endophytic Fungus Int. J. Biol. Macromol. 2024 271 132110 10.1016/j.ijbiomac.2024.132110
Chen G. Xu Z. Wang F. Liu L. Wei Y. Li J. Zhang L. Zheng K. Wu L. Men X. Extraction, Characterization, and Biological Activities of Exopolysaccharides from Plant Root Soil Fungus Fusarium merismoides A6 Braz. J. Microbiol. 2023 54 199 211 10.1007/s42770-022-00842-x
Vadnerker P. Vyas T. Kapadia C. Characterization of Exopolysaccharide Produced by Ganoderma sp. TP and Its Immunomodulatory Properties Romanian Biotechnol. Lett. 2022 28 3527 3535 10.25083/rbl/27.3/3527.3535
Castro S. Garay S. Espinoza-Carhuancho F. Medina J. Mendoza R. Mauricio F. Mayta-Tovalino F. Exploring the Potential of Probiotics in Dentistry: A Literature Review Odovtos-Int. J. Dent. Sci. 2024 26 24 36 10.15517/ijds.2024.59138
Vanin A.P. Visentin E.Z. Fontana R.C. di Medeiros Leal M.C.B. de Avila e Silva S. Stokke B.T. Carbonero E.R. Camassola M. β-(1 → 3)(1 → 6)Glucan from Schizophyllum commune 227E.32: High Yield Production via Glucose/Xylose Co-Metabolization Carbohydr. Polym. 2023 320 121176 10.1016/j.carbpol.2023.121176 37659785
Laroche C. Exopolysaccharides from Microalgae and Cyanobacteria: Diversity of Strains, Production Strategies, and Applications Mar. Drugs 2022 20 336 10.3390/md20050336 35621987
Babiak W. Krzemińska I. Extracellular Polymeric Substances (EPS) as Microalgal Bioproducts: A Review of Factors Affecting EPS Synthesis and Application in Flocculation Processes Energies 2021 14 4007 10.3390/en14134007
Moreira J.B. Kuntzler S.G. Bezerra P.Q.M. Cassuriaga A.P.A. Zaparoli M. da Silva J.L.V. Costa J.A.V. de Morais M.G. Recent Advances of Microalgae Exopolysaccharides for Application as Bioflocculants Polysaccharides 2022 3 264 276 10.3390/polysaccharides3010015
Visentin T.G. Guimarães B.M. Bastos R.G. Effects of Temperature, pH, and C/N Ratio of Sugarcane Wastewater Processing (Vinasse) on Phormidium autumnale Heterotrophic Cultivation Algal Res. 2024 77 103349 10.1016/j.algal.2023.103349
Drira M. Elleuch J. Hlima H.B. Hentati F. Gardarin C. Rihouey C. Cerf D.L. Michaud P. Abdelkafi S. Fendri I. Optimization of Exopolysaccharides Production by Porphyridium sordidum and Their Potential to Induce Defense Responses in Arabidopsis thaliana against Fusarium oxysporum Biomolecules 2021 11 282 10.3390/biom11020282
Borjas Esqueda A. Gardarin C. Laroche C. Exploring the Diversity of Red Microalgae for Exopolysaccharide Production Mar. Drugs 2022 20 246 10.3390/md20040246 35447919
Hayashi T. Hayashi K. Maeda M. Kojima I. Calcium Spirulan, an Inhibitor of Enveloped Virus Replication, from a Blue-Green Alga Spirulina platensis J. Nat. Prod. 1996 59 83 87 10.1021/np960017o
Uhliariková I. Šutovská M. Barboríková J. Molitorisová M. Kim H.J. Park Y.I. Matulová M. Lukavský J. Hromadková Z. Capek P. Structural Characteristics and Biological Effects of Exopolysaccharide Produced by Cyanobacterium nostoc sp Int. J. Biol. Macromol. 2020 160 364 371 10.1016/j.ijbiomac.2020.05.135
Tiwari O.N. Mondal A. Bhunia B. Bandyopadhyay T.K. Jaladi P. Oinam G. Indrama T. Purification, Characterization and Biotechnological Potential of New Exopolysaccharide Polymers Produced by Cyanobacterium Anabaena sp. CCC 745 Polymer 2019 178 121695 10.1016/j.polymer.2019.121695
Uhliariková I. Matulová M. Košťálová Z. Lukavský J. Capek P. Lactylated Acidic Exopolysaccharide Produced by the Cyanobacterium Nostoc Cf Linckia. Carbohydr. Polym. 2022 276 118801 10.1016/j.carbpol.2021.118801 34823807
Gongi W. Gomez Pinchetti J.L. Cordeiro N. Ouada H.B. Extracellular Polymeric Substances Produced by the Thermophilic Cyanobacterium Gloeocapsa gelatinosa: Characterization and Assessment of Their Antioxidant and Metal-Chelating Activities Mar. Drugs 2022 20 227 10.3390/md20040227
Patel A. Prajapat J.B. Food and Health Applications of Exopolysaccharides Produced by Lactic Acid Bacteria Adv. Dairy Res. 2013 1 107
Yang B.-K. Ha J.-Y. Jeong S.-C. Das S. Yun J.-W. Lee Y.-S. Choi J.-W. Song C.-H. Production of Exo-Polymers by Submerged Mycelial Culture of Cordyceps Militaris and Its Hypolipidemic Effect J. Microbiol. Biotechnol. 2000 10 784 788
Shih L. Yu J.-Y. Hsieh C. Wu J.-Y. Production and Characterization of Curdlan by Agrobacterium sp Biochem. Eng. J. 2009 43 33 40 10.1016/j.bej.2008.08.006
Yang M. Zhu Y. Li Y. Bao J. Fan X. Qu Y. Wang Y. Hu Z. Li Q. Production and Optimization of Curdlan Produced by Pseudomonas sp. QL212 Int. J. Biol. Macromol. 2016 89 25 34 10.1016/j.ijbiomac.2016.04.027
Monsan P. Bozonnet S. Albenne C. Joucla G. Willemot R.-M. Remaud-Siméon M. Homopolysaccharides from Lactic Acid Bacteria Int. Dairy J. 2001 11 675 685 10.1016/S0958-6946(01)00113-3
Rosalam S. England R. Review of Xanthan Gum Production from Unmodified Starches by Xanthomonas comprestris sp Enzyme Microb. Technol. 2006 39 197 207 10.1016/j.enzmictec.2005.10.019
Prajapati V.D. Jani G.K. Khanda S.M. Pullulan: An Exopolysaccharide and Its Various Applications Carbohydr. Polym. 2013 95 540 549 10.1016/j.carbpol.2013.02.082
Cheng K.-C. Demirci A. Catchmark J.M. Pullulan: Biosynthesis, Production, and Applications Appl. Microbiol. Biotechnol. 2011 92 29 44 10.1007/s00253-011-3477-y 21800030
Kırtel O. Avşar G. Erkorkmaz B.A. Öner E.T. Microbial Polysaccharides as Food Ingredients Microbial Production of Food Ingredients and Additives Elsevier Amsterdam, The Netherlands 2017 347 383
Coviello T. Palleschi A. Grassi M. Matricardi P. Bocchinfuso G. Alhaique F. Scleroglucan: A Versatile Polysaccharide for Modified Drug Delivery Molecules 2005 10 6 33 10.3390/10010006 18007275
Xu X. Yan H. Tang J. Chen J. Zhang X. Polysaccharides in Lentinus Edodes: Isolation, Structure, Immunomodulating Activity and Future Prospective Crit. Rev. Food Sci. Nutr. 2014 54 474 487 10.1080/10408398.2011.587616 24236998
Giavasis I. Production of Microbial Polysaccharides for Use in Food Microbial Production of Food Ingredients, Enzymes and Nutraceuticals Elsevier Amsterdam, The Netherlands 2013 413 468
Giavasis I. Seviour R.J. Hudman P. McNeil B. Fungal bioproducts for use in food: Polysaccharides, organic acids, and mycoprotein Advances in Food Bioproducts and Bioprocessing Technologies CRC Press Boca Raton, FL, USA 2019 511 548
Babitskaya V.G. Shcherba V.V. Puchkova T.A. Smirnov D.A. Polysaccharides of Ganoderma Lucidum: Factors Affecting Their Production Appl. Biochem. Microbiol. 2005 41 169 173 10.1007/s10438-005-0029-1
Meng X. Liang H. Luo L. Antitumor Polysaccharides from Mushrooms: A Review on the Structural Characteristics, Antitumor Mechanisms and Immunomodulating Activities Carbohydr. Res. 2016 424 30 41 10.1016/j.carres.2016.02.008
Yamanaka D. Liu Y. Motoi M. Ohno N. Royal Sun Medicinal Mushroom, Agaricus brasiliensis Ka21 (Higher Basidiomycetes), as a Functional Food in Humans Int. J. Med. Mushrooms 2013 15 335 343 10.1615/IntJMedMushr.v15.i4.10
Liu Y.-S. Wu J.-Y. Effects of Tween 80 and pH on Mycelial Pellets and Exopolysaccharide Production in Liquid Culture of a Medicinal Fungus J. Ind. Microbiol. Biotechnol. 2012 39 623 628 10.1007/s10295-011-1066-9 22143435
Yu Y. Shen M. Song Q. Xie J. Biological Activities and Pharmaceutical Applications of Polysaccharide from Natural Resources: A Review Carbohydr. Polym. 2018 183 91 101 10.1016/j.carbpol.2017.12.009
Jayachandran M. Chen J. Chung S.S.M. Xu B. A Critical Review on the Impacts of β-Glucans on Gut Microbiota and Human Health J. Nutr. Biochem. 2018 61 101 110 10.1016/j.jnutbio.2018.06.010
Mishima T. Murata J. Toyoshima M. Fujii H. Nakajima M. Hayashi T. Kato T. Saiki I. Inhibition of Tumor Invasion and Metastasis by Calciumspirulan (Ca-SP), a Novel Sulfated Polysaccharide Derived from a Blue-Green Alga, Spirulina Platensis Clin. Exp. Metastasis 1998 16 541 550 10.1023/A:1006594318633
De Philippis R. Vincenzini M. Exocellular Polysaccharides from Cyanobacteria and Their Possible Applications FEMS Microbiol. Rev. 1998 22 151 175 10.1016/S0168-6445(98)00012-6
Delattre C. Pierre G. Laroche C. Michaud P. Production, Extraction and Characterization of Microalgal and Cyanobacterial Exopolysaccharides Biotechnol. Adv. 2016 34 1159 1179 10.1016/j.biotechadv.2016.08.001 27530696
Pereira S. Zille A. Micheletti E. Moradas-Ferreira P. De Philippis R. Tamagnini P. Complexity of Cyanobacterial Exopolysaccharides: Composition, Structures, Inducing Factors and Putative Genes Involved in Their Biosynthesis and Assembly FEMS Microbiol. Rev. 2009 33 917 941 10.1111/j.1574-6976.2009.00183.x 19453747
Pathak J. Rajneesh R. Sonker A.S. Kannaujiya V.K. Sinha R.P. Cyanobacterial extracellular polysaccharide sheath pigment, scytonemin: A novel multipurpose pharmacophore Marine Glycobiology CRC Press Boca Raton, FL, USA 2016 978-1-315-37139-9
Cruz D. Vasconcelos V. Pierre G. Michaud P. Delattre C. Exopolysaccharides from Cyanobacteria: Strategies for Bioprocess Development Appl. Sci. 2020 10 3763 10.3390/app10113763
Diengdoh O.L. Syiem M.B. Pakshirajan K. Rai A.N. Zn2+ Sequestration by Nostoc muscorum: Study of Thermodynamics, Equilibrium Isotherms, and Biosorption Parameters for the Metal Environ. Monit. Assess. 2017 189 314 10.1007/s10661-017-6013-4
Mota R. Rossi F. Andrenelli L. Pereira S.B. De Philippis R. Tamagnini P. Released Polysaccharides (RPS) from Cyanothece sp. CCY 0110 as Biosorbent for Heavy Metals Bioremediation: Interactions between Metals and RPS Binding Sites Appl. Microbiol. Biotechnol. 2016 100 7765 7775 10.1007/s00253-016-7602-9
Shakeri M. Naji-Tabasi S. Characterization and Optimization of Gellan Gum Production by Natural Sphingomonas sp. SM2 LWT 2024 200 116164 10.1016/j.lwt.2024.116164
Liu Z. Xu Y. Wang Z. Zhu L. Li Z. Jiang Y. Zhan X. Gao M. Promoting Substrates Uptake and Curdlan Synthesis of Agrobacterium sp. by Attenuating the Exopolysaccharide Encapsulation Carbohydr. Polym. 2023 315 120941 10.1016/j.carbpol.2023.120941
Seviour R.J. McNeil B. Fazenda M.L. Harvey L.M. Operating Bioreactors for Microbial Exopolysaccharide Production Crit. Rev. Biotechnol. 2011 31 170 185 10.3109/07388551.2010.505909
Cao J. Zhang H.-J. Xu C.-P. Culture Characterization of Exopolysaccharides with Antioxidant Activity Produced by Pycnoporus sanguineus in Stirred-Tank and Airlift Reactors J. Taiwan Inst. Chem. Eng. 2014 45 2075 2080 10.1016/j.jtice.2014.05.005
Usuldin S.R.A. Ilham Z. Jamaludin A.A. Ahmad R. Wan-Mohtar W.A.A.Q.I. Enhancing Biomass-Exopolysaccharides Production of Lignosus rhinocerus in a High-Scale Stirred-Tank Bioreactor and Its Potential Lipid as Bioenergy Energies 2023 16 2330 10.3390/en16052330
Jaswal A.S. Elangovan R. Mishra S. Synthesis and Molecular Characterization of Levan Produced by Immobilized Microbacterium paraoxydans J. Biotechnol. 2023 373 63 72 10.1016/j.jbiotec.2023.07.003 37451319
Namdeo N. Kumar B. Jha H. Bioreactor Design for the Production of Microbial Polysaccharides Microbial Exopolysaccharides CRC Press Boca Raton, FL, USA 2024 978-1-00-334268-7
Finore I. Di Donato P. Mastascusa V. Nicolaus B. Poli A. Fermentation Technologies for the Optimization of Marine Microbial Exopolysaccharide Production Mar. Drugs 2014 12 3005 3024 10.3390/md12053005 24857960
Kumar M.A. Anandapandian K.T.K. Parthiban K. Production and Characterization of Exopolysaccharides (EPS) from Biofilm Forming Marine Bacterium Braz. Arch. Biol. Technol. 2011 54 259 265 10.1590/S1516-89132011000200006
Sanalibaba P. Cakmak G.A. Exopolysaccharides Production by Lactic Acid Bacteria Appl. Microbiol. Open Access 2016 2 1000115 10.4172/2471-9315.1000115
Leroy F. De Vuyst L. Advances in Production and Simplified Methods for Recovery and Quantification of Exopolysaccharides for Applications in Food and Health1 J. Dairy Sci. 2016 99 3229 3238 10.3168/jds.2015-9936
Nguyen H.T. Razafindralambo H. Blecker C. N’Yapo C. Thonart P. Delvigne F. Stochastic Exposure to Sub-Lethal High Temperature Enhances Exopolysaccharides (EPS) Excretion and Improves Bifidobacterium bifidum Cell Survival to Freeze–Drying Biochem. Eng. J. 2014 88 85 94 10.1016/j.bej.2014.04.005
Higgins M.J. Novak J.T. Characterization of Exocellular Protein and Its Role in Bioflocculation J. Environ. Eng. 1997 123 479 485 10.1061/(ASCE)0733-9372(1997)123:5(479)
Yegorenkova I.V. Tregubova K.V. Matora L.Y. Burygin G.L. Ignatov V.V. Biofilm Formation by Paenibacillus polymyxa Strains Differing in the Production and Rheological Properties of Their Exopolysaccharides Curr. Microbiol. 2011 62 1554 1559 10.1007/s00284-011-9896-2
Poli A. Di Donato P. Abbamondi G.R. Nicolaus B. Synthesis, Production, and Biotechnological Applications of Exopolysaccharides and Polyhydroxyalkanoates by Archaea Archaea 2011 2011 693253 10.1155/2011/693253
O’Toole G. Kaplan H.B. Kolter R. Biofilm Formation as Microbial Development Annu. Rev. Microbiol. 2000 54 49 79 10.1146/annurev.micro.54.1.49 11018124
Schwarzmann S. Boring J.R. Antiphagocytic Effect of Slime from a Mucoid Strain of Pseudomonas aeruginosa Infect. Immun. 1971 3 762 767 10.1128/iai.3.6.762-767.1971 16558051
Ruas-Madiedo P. Hugenholtz J. Zoon P. An Overview of the Functionality of Exopolysaccharides Produced by Lactic Acid Bacteria Int. Dairy J. 2002 12 163 171 10.1016/S0958-6946(01)00160-1
Li W. Ji J. Rui X. Yu J. Tang W. Chen X. Jiang M. Dong M. Production of Exopolysaccharides by Lactobacillus helveticus MB2-1 and Its Functional Characteristics in Vitro LWT Food Sci. Technol. 2014 59 732 739 10.1016/j.lwt.2014.06.063
Khan W. Hosseinkhani H. Ickowicz D. Hong P.-D. Yu D.-S. Domb A.J. Polysaccharide Gene Transfection Agents Acta Biomater. 2012 8 4224 4232 10.1016/j.actbio.2012.09.022
Zhang Y. Kong H. Fang Y. Nishinari K. Phillips G.O. Schizophyllan: A Review on Its Structure, Properties, Bioactivities and Recent Developments Bioact. Carbohydr. Diet. Fibre 2013 1 53 71 10.1016/j.bcdf.2013.01.002
Park M. Lee D. Hyun J. Nanocellulose-Alginate Hydrogel for Cell Encapsulation Carbohydr. Polym. 2015 116 223 228 10.1016/j.carbpol.2014.07.059
Albadran H.A. Chatzifragkou A. Khutoryanskiy V.V. Charalampopoulos D. Development of Surfactant-Coated Alginate Capsules Containing Lactobacillus plantarum Food Hydrocoll. 2018 82 490 499 10.1016/j.foodhyd.2018.04.035
Zhu C.-Z. Li D. Chen W.-J. Ban S.-N. Liu T. Wen H. Jiang M. Effects of Dietary Host-Associated Lactococcus lactis on Growth Performance, Disease Resistance, Intestinal Morphology and Intestinal Microbiota of Mandarin Fish (Siniperca chuatsi) Aquaculture 2021 540 736702 10.1016/j.aquaculture.2021.736702
Walker A.W. Duncan S.H. McWilliam Leitch E.C. Child M.W. Flint H.J. pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon Appl. Environ. Microbiol. 2005 71 3692 3700 10.1128/AEM.71.7.3692-3700.2005
Rios-Covian D. Cuesta I. Alvarez-Buylla J.R. Ruas-Madiedo P. Gueimonde M. de los Reyes-Gavilán C.G. Bacteroides fragilis Metabolises Exopolysaccharides Produced by Bifidobacteria BMC Microbiol. 2016 16 150 10.1186/s12866-016-0773-9 27418149
Fanning S. Hall L.J. Cronin M. Zomer A. MacSharry J. Goulding D. O’Connell Motherway M. Shanahan F. Nally K. Dougan G. et al. Bifidobacterial Surface-Exopolysaccharide Facilitates Commensal-Host Interaction through Immune Modulation and Pathogen Protection Proc. Natl. Acad. Sci. USA 2012 109 2108 2113 10.1073/pnas.1115621109
Balzaretti S. Taverniti V. Guglielmetti S. Fiore W. Minuzzo M. Ngo H.N. Ngere J.B. Sadiq S. Humphreys P.N. Laws A.P. A Novel Rhamnose-Rich Hetero-Exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells Appl. Environ. Microbiol. 2017 83 e02702-16 10.1128/AEM.02702-16
Bengoa A.A. Llamas M.G. Iraporda C. Dueñas M.T. Abraham A.G. Garrote G.L. Impact of Growth Temperature on Exopolysaccharide Production and Probiotic Properties of Lactobacillus paracasei Strains Isolated from Kefir Grains Food Microbiol. 2018 69 212 218 10.1016/j.fm.2017.08.012 28941904
Trabelsi I. Ktari N. Slima S.B. Triki M. Bardaa S. Mnif H. Salah R.B. Evaluation of Dermal Wound Healing Activity and in Vitro Antibacterial and Antioxidant Activities of a New Exopolysaccharide Produced by Lactobacillus sp. Ca6 Int. J. Biol. Macromol. 2017 103 194 201 10.1016/j.ijbiomac.2017.05.017
Jeong D. Kim D.-H. Kang I.-B. Kim H. Song K.-Y. Kim H.-S. Seo K.-H. Characterization and Antibacterial Activity of a Novel Exopolysaccharide Produced by Lactobacillus kefiranofaciens DN1 Isolated from Kefir Food Control 2017 78 436 442 10.1016/j.foodcont.2017.02.033
Zhou Y. Cui Y. Qu X. Exopolysaccharides of Lactic Acid Bacteria: Structure, Bioactivity and Associations: A Review Carbohydr. Polym. 2019 207 317 332 10.1016/j.carbpol.2018.11.093 30600013
Bhat B. Bajaj B.K. Hypocholesterolemic and Bioactive Potential of Exopolysaccharide from a Probiotic Enterococcus faecium K1 Isolated from Kalarei Bioresour. Technol. 2018 254 264 267 10.1016/j.biortech.2018.01.078
Sasikumar K. Vaikkath D.K. Devendra L. Nampoothiri K.M. An Exopolysaccharide (EPS) from a Lactobacillus plantarum BR2 with Potential Benefits for Making Functional Foods Bioresour. Technol. 2017 241 1152 1156 10.1016/j.biortech.2017.05.075
Ishimwe N. Daliri E.B. Lee B.H. Fang F. Du G. The Perspective on Cholesterol-lowering Mechanisms of Probiotics Mol. Nutr. Food Res. 2015 59 94 105 10.1002/mnfr.201400548
Michael D.R. Davies T.S. Moss J.W.E. Calvente D.L. Ramji D.P. Marchesi J.R. Pechlivanis A. Plummer S.F. Hughes T.R. The Anti-Cholesterolaemic Effect of a Consortium of Probiotics: An Acute Study in C57BL/6J Mice Sci. Rep. 2017 7 2883 10.1038/s41598-017-02889-5 28588193
Li H. Mao W. Hou Y. Gao Y. Qi X. Zhao C. Chen Y. Chen Y. Li N. Wang C. Preparation, Structure and Anticoagulant Activity of a Low Molecular Weight Fraction Produced by Mild Acid Hydrolysis of Sulfated Rhamnan from Monostroma latissimum Bioresour. Technol. 2012 114 414 418 10.1016/j.biortech.2012.03.025 22472640
Li N. Liu X. He X. Wang S. Cao S. Xia Z. Xian H. Qin L. Mao W. Structure and Anticoagulant Property of a Sulfated Polysaccharide Isolated from the Green Seaweed Monostroma angicava Carbohydr. Polym. 2017 159 195 206 10.1016/j.carbpol.2016.12.013
Rani R.P. Anandharaj M. Ravindran A.D. Characterization of a Novel Exopolysaccharide Produced by Lactobacillus Gasseri FR4 and Demonstration of Its in Vitro Biological Properties Int. J. Biol. Macromol. 2018 109 772 783 10.1016/j.ijbiomac.2017.11.062
Guo Y. Pan D. Li H. Sun Y. Zeng X. Yan B. Antioxidant and Immunomodulatory Activity of Selenium Exopolysaccharide Produced by Lactococcus lactis subsp. Lactis Food Chem. 2013 138 84 89 10.1016/j.foodchem.2012.10.029
Pan D. Mei X. Antioxidant Activity of an Exopolysaccharide Purified from Lactococcus lactis subsp. Lactis 12 Carbohydr. Polym. 2010 80 908 914 10.1016/j.carbpol.2010.01.005
Nácher-Vázquez M. Ballesteros N. Canales Á. Saint-Jean S.R. Pérez-Prieto S.I. Prieto A. Aznar R. López P. Dextrans Produced by Lactic Acid Bacteria Exhibit Antiviral and Immunomodulatory Activity against Salmonid Viruses Carbohydr. Polym. 2015 124 292 301 10.1016/j.carbpol.2015.02.020
Ren W. Xia Y. Wang G. Zhang H. Zhu S. Ai L. Bioactive Exopolysaccharides from a S. thermophilus Strain: Screening, Purification and Characterization Int. J. Biol. Macromol. 2016 86 402 407 10.1016/j.ijbiomac.2016.01.085
Wang K. Li W. Rui X. Chen X. Jiang M. Dong M. Characterization of a Novel Exopolysaccharide with Antitumor Activity from Lactobacillus plantarum 70810 Int. J. Biol. Macromol. 2014 63 133 139 10.1016/j.ijbiomac.2013.10.036
Singh P. Saini P. Food and Health Potentials of Exopolysaccharides Derived from Lactobacilli Microbiol. Res. J. Int. 2017 22 1 14 10.9734/MRJI/2017/36935
Kim K. Lee G. Thanh H.D. Kim J.-H. Konkit M. Yoon S. Park M. Yang S. Park E. Kim W. Exopolysaccharide from Lactobacillus plantarum LRCC5310 Offers Protection against Rotavirus-Induced Diarrhea and Regulates Inflammatory Response J. Dairy Sci. 2018 101 5702 5712 10.3168/jds.2017-14151 29627242
Liu J. Thorp S.C. Cell Surface Heparan Sulfate and Its Roles in Assisting Viral Infections Med. Res. Rev. 2002 22 1 25 10.1002/med.1026 11746174
Liao Y. Wang R. Qin X. Ma X. Liu X. Jia S. Zhong C. A β-Glucan from Aureobasidium pullulans Enhanced the Antitumor Effect with Rituximab against SU-DHL-8 Int. J. Biol. Macromol. 2022 220 1356 1367 10.1016/j.ijbiomac.2022.09.106
Khalil M.A. Sonbol F.I. Al-Madboly L.A. Aboshady T.A. Alqurashi A.S. Ali S.S. Exploring the Therapeutic Potentials of Exopolysaccharides Derived from Lactic Acid Bacteria and Bifidobacteria: Antioxidant, Antitumor, and Periodontal Regeneration Front. Microbiol. 2022 13 803688 10.3389/fmicb.2022.803688 35547125
Sheng S. Fu Y. Pan N. Zhang H. Xiu L. Liang Y. Liu Y. Liu B. Ma C. Du R. et al. Novel Exopolysaccharide Derived from Probiotic Lactobacillus pantheris TCP102 Strain with Immune-Enhancing and Anticancer Activities Front. Microbiol. 2022 13 1015270 10.3389/fmicb.2022.1015270
Xiong J. Liu D. Huang Y. Exopolysaccharides from Lactiplantibacillus plantarum: Isolation, Purification, Structure–Function Relationship, and Application Eur. Food Res. Technol. 2023 249 1431 1448 10.1007/s00217-023-04237-6
Li F. Jiao X. Zhao J. Liao X. Wei Y. Li Q. Antitumor Mechanisms of an Exopolysaccharide from Lactobacillus fermentum on HT-29 Cells and HT-29 Tumor-Bearing Mice Int. J. Biol. Macromol. 2022 209 552 562 10.1016/j.ijbiomac.2022.04.023
Abdelnasser S.M. Abu-Shahba N. Bacillus sonorinses Derived Exopolysaccharide Enhances Cell Cycle Arrest, Apoptosis, Necrosis, Autophagy and COX-2 down Regulation in Liver Cancer Cells Biotechnol. Rep. 2024 48 e00848 10.1016/j.btre.2024.e00848
Taşkaya A. Güvensen N.C. Güler C. Şancı E. Karabay Ü. Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity J. Agric. Prod. 2023 4 63 71 10.56430/japro.1307611
Zhong X. Wang G. Li F. Fang S. Zhou S. Ishiwata A. Tonevitsky A.G. Shkurnikov M. Cai H. Ding F. Immunomodulatory Effect and Biological Significance of β-Glucans Pharmaceutics 2023 15 1615 10.3390/pharmaceutics15061615
Notararigo S. Varela E. Otal A. Antolín M. Guarner F. López P. Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model Int. J. Mol. Sci. 2022 23 1527 10.3390/ijms23031527 35163449
Yang S. Xu X. Peng Q. Ma L. Qiao Y. Shi B. Exopolysaccharides from Lactic Acid Bacteria, as an Alternative to Antibiotics, on Regulation of Intestinal Health and the Immune System Anim. Nutr. 2023 13 78 89 10.1016/j.aninu.2023.02.004 37025257
Abdalla A.K. Ayyash M.M. Olaimat A.N. Osaili T.M. Al-Nabulsi A.A. Shah N.P. Holley R. Exopolysaccharides as Antimicrobial Agents: Mechanism and Spectrum of Activity Front. Microbiol. 2021 12 664395 10.3389/fmicb.2021.664395 34093478
Wang W. Ju Y. Liu N. Shi S. Hao L. Structural Characteristics of Microbial Exopolysaccharides in Association with Their Biological Activities: A Review Chem. Biol. Technol. Agric. 2023 10 137 10.1186/s40538-023-00515-3
Kiššová Z. Schusterová P. Mudroňová D. Novotný J. Tkáčiková Ľ. Exopolysaccharides from Limosilactobacillus reuteri: Their Influence on in Vitro Activation of Porcine Monocyte-Derived Dendritic Cells-Brief Report Vet. Res. Commun. 2024 1 7 10.1007/s11259-024-10445-6
Rajoka M.S.R. Wu Y. Mehwish H.M. Bansal M. Zhao L. Lactobacillus Exopolysaccharides: New Perspectives on Engineering Strategies, Physiochemical Functions, and Immunomodulatory Effects on Host Health Trends Food Sci. Technol. 2020 103 36 48 10.1016/j.tifs.2020.06.003
Domingos-Lopes M.F.P. Nagy A. Stanton C. Ross P.R. Gelencsér E. Silva C.C.G. Immunomodulatory Activity of Exopolysaccharide Producing Leuconostoc citreum Strain Isolated from Pico Cheese J. Funct. Foods 2017 33 235 243 10.1016/j.jff.2017.03.054
Zhang J. Xiao Y. Wang H. Zhang H. Chen W. Lu W. Lactic Acid Bacteria-Derived Exopolysaccharide: Formation, Immunomodulatory Ability, Health Effects, and Structure-Function Relationship Microbiol. Res. 2023 274 127432 10.1016/j.micres.2023.127432
Dargahi N. Johnson J.C. Apostolopoulos V. Immune Modulatory Effects of Probiotic Streptococcus Thermophilus on Human Monocytes Biologics 2021 1 396 415 10.3390/biologics1030023
Hickey A. Stamou P. Udayan S. Ramón-Vázquez A. Esteban-Torres M. Bottacini F. Woznicki J.A. Hughes O. Melgar S. Ventura M. et al. Bifidobacterium Breve Exopolysaccharide Blocks Dendritic Cell Maturation and Activation of CD4+ T Cells Front. Microbiol. 2021 12 653587 10.3389/fmicb.2021.653587
Liu Y. Zheng S. Cui J. Guo T. Zhang J. Li B. Alleviative Effects of Exopolysaccharide Produced by Lactobacillus helveticus KLDS1. 8701 on Dextran Sulfate Sodium-Induced Colitis in Mice Microorganisms 2021 9 2086 10.3390/microorganisms9102086 34683406
Young I.D. Latousakis D. Juge N. The Immunomodulatory Properties of β-2, 6 Fructans: A Comprehensive Review Nutrients 2021 13 1309 10.3390/nu13041309 33921025
Xu Q. Yajima T. Li W. Saito K. Ohshima Y. Yoshikai Y. Levan (β-2, 6-Fructan), a Major Fraction of Fermented Soybean Mucilage, Displays Immunostimulating Properties via Toll-like Receptor 4 Signalling: Induction of Interleukin-12 Production and Suppression of T-Helper Type 2 Response and Immunoglobulin E Production Clin. Exp. Allergy 2006 36 94 101 10.1111/j.1365-2222.2006.02401.x
Wahab W.A.A. Shafey H.I. Mahrous K.F. Esawy M.A. Saleh S.A.A. Coculture of Bacterial Levans and Evaluation of Its Anti-Cancer Activity against Hepatocellular Carcinoma Cell Lines Sci. Rep. 2024 14 3173 10.1038/s41598-024-52699-9
Aquinas N. Bhat M.R. Selvaraj S. A Review Presenting Production, Characterization, and Applications of Biopolymer Curdlan in Food and Pharmaceutical Sectors Polym. Bull. 2022 79 6905 6927 10.1007/s00289-021-03860-1
Ganie S.A. Rather L.J. Assiri M.A. Li Q. Recent Innovations (2020–2023) in the Approaches for the Chemical Functionalization of Curdlan and Pullulan: A Mini-Review Int. J. Biol. Macromol. 2024 260 129412 10.1016/j.ijbiomac.2024.129412
Andreu S. von Kobbe C. Delgado P. Ripa I. Buzón M.J. Genescà M. Gironès N. del Moral-Salmoral J. Ramírez G.A. Zúñiga S. Dextran Sulfate from Leuconostoc mesenteroides B512F Exerts Potent Antiviral Activity against SARS-CoV-2 in Vitro and in Vivo Front. Microbiol. 2023 14 1185504 10.3389/fmicb.2023.1185504
Mirończuk-Chodakowska I. Kujawowicz K. Witkowska A.M. Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era Nutrients 2021 13 3960 10.3390/nu13113960
Wu N. Ge X. Yin X. Yang L. Chen L. Shao R. Xu W. A Review on Polysaccharide Biosynthesis in Cordyceps militaris Int. J. Biol. Macromol. 2024 260 129336 10.1016/j.ijbiomac.2024.129336
Afreen A. Ahmed Z. Khalid N. Ferheen I. Ahmed I. Optimization and Cholesterol-Lowering Activity of Exopolysaccharide from Lactiplantibacillus paraplantarum NCCP 962 Appl. Microbiol. Biotechnol. 2023 107 1189 1204 10.1007/s00253-023-12372-z
Zhao X. Zhong X. Liu X. Wang X. Gao X. Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective from Gut Microbiota Front. Nutr. 2021 8 693412
Al-Nabulsi A.A. Jaradat Z.W. Qudsi F.R.A. Elsalem L. Osaili T.M. Olaimat A.N. Esposito G. Liu S.-Q. Ayyash M.M. Characterization and Bioactive Properties of Exopolysaccharides Produced by Streptococcus thermophilus and Lactobacillus bulgaricus Isolated from Labaneh LWT 2022 167 113817 10.1016/j.lwt.2022.113817
Aloraini G.S. Albureikan M.O.I. Shahlol A.M.A. Shamrani T. Daghistani H. El-Nablaway M. Tharwat N.A. Elazzazy A.M. Basyony A.F. Ghareeb A. Biomedical and Therapeutic Potential of Marine-Derived Pseudomonas sp. Strain AHG22 Exopolysaccharide: A Novel Bioactive Microbial Metabolite Rev. Adv. Mater. Sci. 2024 63 20240016 10.1515/rams-2024-0016
Ge Z. Wang D. Azi F. Zhao W. Wang P. Dong M. Wang J. Zhao Y. Zhao X. The Optimization of in Situ Exopolysaccharides Production in Lactobacillus helveticus MB2-1 Fermented Milk and Its Functional Characteristics in Vitro Int. Dairy J. 2024 155 105969 10.1016/j.idairyj.2024.105969
Carvalho F.M. Teixeira-Santos R. Mergulhao F.J.M. Gomes L.C. The Use of Probiotics to Fight Biofilms in Medical Devices: A Systematic Review and Meta-Analysis Microorganisms 2020 9 27 10.3390/microorganisms9010027 33374844
Giordani B. Parolin C. Vitali B. Lactobacilli as Anti-Biofilm Strategy in Oral Infectious Diseases: A Mini-Review Front. Med. Technol. 2021 3 769172 10.3389/fmedt.2021.769172
Song Y. Sun M. Feng L. Liang X. Song X. Mu G. Tuo Y. Jiang S. Qian F. Antibiofilm Activity of Lactobacillus plantarum 12 Exopolysaccharides against Shigella flexneri Appl. Environ. Microbiol. 2020 86 e00694-20 10.1128/AEM.00694-20 32444475
Aliouche N. Sifour M. Kebsa W. Khennouf T. Ercan F. Ouled-Haddar H. Prophylactic Effect and Antiulcerogenic Potential of Probiotic Lactiplantibacillus plantarum E1K2R2 and Its Exopolysaccharide against Ibuprofen-Induced Acute Gastric Ulcer Probiotics Antimicrob. Proteins 2024 2024 1 16 10.1007/s12602-024-10321-4
Yu J. Chen Z. Zhou Q. Li P. Wu S. Zhou T. Gu Q. Exopolysaccharide from Lacticaseibacillus paracasei Alleviates Gastritis in Helicobacter Pylori-Infected Mice by Regulating Gastric Microbiota Front. Nutr. 2024 11 1426358 10.3389/fnut.2024.1426358
Al-Qaysi S.A.S. Al-Haideri H. Al-Shimmary S.M. Abdulhameed J.M. Alajrawy O.I. Al-Halbosiy M.M. Moussa T.A.A. Farahat M.G. Bioactive Levan-Type Exopolysaccharide Produced by Pantoea agglomerans ZMR7: Characterization and Optimization for Enhanced Production J. Microbiol. Biotechnol. 2021 31 696 10.4014/jmb.2101.01025
Erdal Altıntaş Ö. Toksoy Öner E. Çabuk A. Aytar Çelik P. Biosynthesis of Levan by Halomonas elongata 153B: Optimization for Enhanced Production and Potential Biological Activities for Pharmaceutical Field J. Polym. Environ. 2023 31 1440 1455 10.1007/s10924-022-02681-1
Cao C. Bian Y. Cang W. Wu J. Wu R. Structural Characterization and Hepatoprotective Activity of Exopolysaccharide from Bacillus velezensis SN-1 J. Sci. Food Agric. 2023 103 738 749 10.1002/jsfa.12185
Lee M.-G. Joeng H. Shin J. Kim S. Lee C. Song Y. Lee B.-H. Park H.-G. Lee T.-H. Jiang H.-H. Potential Probiotic Properties of Exopolysaccharide-Producing Lacticaseibacillus paracasei EPS DA-BACS and Prebiotic Activity of Its Exopolysaccharide Microorganisms 2022 10 2431 10.3390/microorganisms10122431 36557684
Bisson G. Comuzzi C. Giordani E. Poletti D. Boaro M. Marino M. An Exopolysaccharide from Leuconostoc mesenteroides Showing Interesting Bioactivities versus Foodborne Microbial Targets Carbohydr. Polym. 2023 301 120363 10.1016/j.carbpol.2022.120363
Kavitake D. Tiwari S. Shah I.A. Devi P.B. Delattre C. Reddy G.B. Shetty P.H. Antipathogenic Potentials of Exopolysaccharides Produced by Lactic Acid Bacteria and Their Food and Health Applications Food Control 2023 152 109850 10.1016/j.foodcont.2023.109850
Ma L. Xu X. Peng Q. Yang S. Zhang Y. Tian D. Shi L. Qiao Y. Shi B. Exopolysaccharide from Lactobacillus casei NA-2 Attenuates Escherichia coli O157:H7 Surface Adhesion via Modulation of Membrane Surface Properties and Adhesion-Related Gene Expression Microb. Pathog. 2022 173 105863 10.1016/j.micpath.2022.105863 36332791
Zammuto V. Spanò A. Agostino E. Macrì A. De Pasquale C. Ferlazzo G. Rizzo M.G. Nicolò M.S. Guglielmino S. Gugliandolo C. Anti-Bacterial Adhesion on Abiotic and Biotic Surfaces of the Exopolysaccharide from the Marine Bacillus Licheniformis B3-15 Mar. Drugs 2023 21 313 10.3390/md21050313
IS W.B. Biofilm Development and Approaches to Biofilm Inhibition by Exopolysaccharides New Microbiol. 2022 45 227 236
Giordani B. Naldi M. Croatti V. Parolin C. Erdoğan Ü. Bartolini M. Vitali B. Exopolysaccharides from Vaginal lactobacilli Modulate Microbial Biofilms Microb. Cell Factories 2023 22 45 10.1186/s12934-023-02053-x
Tao T. Zhang L. Yu T. Ma J. Lu S. Ren J. Li X. Guo X. Exopolysaccharide Production by Lactobacillus Plantarum T10 Is Responsible for the Probiotic Activity in Enhancing Intestinal Barrier Function in Vitro and in Vivo Food Funct. 2024 15 3583 3599 10.1039/D4FO00526K
Xie Y. Pei F. Liu Y. Liu Z. Chen X. Xue D. Fecal Fermentation and High-Fat Diet-Induced Obesity Mouse Model Confirmed Exopolysaccharide from Weissella cibaria PFY06 Can Ameliorate Obesity by Regulating the Gut Microbiota Carbohydr. Polym. 2023 318 121122 10.1016/j.carbpol.2023.121122 37479437
Pérez-Rivero C. López-Gómez J.P. Unlocking the Potential of Fermentation in Cosmetics: A Review Fermentation 2023 9 463 10.3390/fermentation9050463
Mahmoud M.G. Awady M.E.E. Selim M.S. Ibrahim A.Y. Ibrahim F.M. Mohamed S.S. Characterization of Biologically Active Exopolysaccharide Produced by Streptomyces sp. NRCG4 and Its Anti-Alzheimer Efficacy: In-Vitro Targets J. Genet. Eng. Biotechnol. 2023 21 76 10.1186/s43141-023-00530-9 37400624
Sirin S. Aslim B. Characterization of Lactic Acid Bacteria Derived Exopolysaccharides for Use as a Defined Neuroprotective Agent against Amyloid Beta1–42-Induced Apoptosis in SH-SY5Y Cells Sci. Rep. 2020 10 8124 10.1038/s41598-020-65147-1
Darilmaz D.O. Beyatli Y. Investigating Hydrophobicity and the Effect of Exopolysaccharide on Aggregation Properties of Dairy Propionibacteria Isolated from Turkish Homemade Cheeses J. Food Prot. 2012 75 359 365 10.4315/0362-028X.JFP-11-225
Hooshdar P. Kermanshahi R.K. Ghadam P. Khosravi-Darani K. A Review on Production of Exopolysaccharide and Biofilm in Probiotics Like Lactobacilli and Methods of Analysis Biointerface Res. Appl. Chem. 2020 10 6058 6075 10.33263/BRIAC105.60586075
Jahr H. Bahro R. Eichenlaub R. Genetics of phytopathology: Phytopathogenic bacteria Progress in Botany: Genetics Cell Biology and Physiology Systematics and Comparative Morphology Ecology and Vegetation Science Esser K. Kadereit J.W. Lüttge U. Runge M. Springer Berlin/Heidelberg, Germany 1999 119 138 978-3-642-59940-8
d’Abzac P. Bordas F. Joussein E. Van Hullebusch E.D. Piet N.L. Guibaud G. Metal Binding Properties of Extracellular Polymeric Substances Extracted from Anaerobic Granular Sludges Environ. Sci. Pollut. Res. 2013 20 4509 4519 10.1007/s11356-012-1401-3
Zhang Y. Li D. Yang N. Jin Z. Xu X. Comparison of Dextran Molecular Weight on Wheat Bread Quality and Their Performance in Dough Rheology and Starch Retrogradation LWT 2018 98 39 45
Du R. Yu L. Yu N. Ping W. Song G. Ge J. Characterization of Exopolysaccharide Produced by Levilactobacillus brevis HDE-9 and Evaluation of Its Potential Use in Dairy Products Int. J. Biol. Macromol. 2022 217 303 311 10.1016/j.ijbiomac.2022.07.057
Kavitake D. Tiwari S. Devi P.B. Shah I.A. Reddy G.B. Shetty P.H. Production, Purification, and Functional Characterization of Glucan Exopolysaccharide Produced by Enterococcus Hirae Strain OL616073 of Fermented Food Origin Int. J. Biol. Macromol. 2024 259 129105 10.1016/j.ijbiomac.2023.129105 38176508
Mummaleti G. Sarma C. Yarrakula S. Urla R. Gazula H. Production, Properties and Applications of Levan Polysaccharide Food Humanit. 2024 3 100369 10.1016/j.foohum.2024.100369
Tintoré M. Cuñé J. Vu L.D. Poppe J. Van den Abbeele P. Baudot A. de Lecea C. A Long-Chain Dextran Produced by Weissella cibaria Boosts the Diversity of Health-Related Gut Microbes Ex Vivo Biology 2024 13 51 10.3390/biology13010051 38248481
Besrour-Aouam N. Fhoula I. Hernández-Alcántara A.M. Mohedano M.L. Najjari A. Prieto A. Ruas-Madiedo P. López P. Ouzari H.-I. The Role of Dextran Production in the Metabolic Context of Leuconostoc and Weissella Tunisian Strains Carbohydr. Polym. 2021 253 117254
Georgalaki M. Zoumpopoulou G. Anastasiou R. Kazou M. Tsakalidou E. Lactobacillus kefiranofaciens: From Isolation and Taxonomy to Probiotic Properties and Applications Microorganisms 2021 9 2158 10.3390/microorganisms9102158
Bibi A. Xiong Y. Rajoka M.S.R. Mehwish H.M. Radicetti E. Umair M. Shoukat M. Khan M.K.I. Aadil R.M. Recent Advances in the Production of Exopolysaccharide (EPS) from Lactobacillus spp. and Its Application in the Food Industry: A Review Sustainability 2021 13 12429 10.3390/su132212429
Kavitake D. Balyan S. Devi P.B. Shetty P.H. Evaluation of Oil-in-Water (O/W) Emulsifying Properties of Galactan Exopolysaccharide from Weissella confusa KR780676 J. Food Sci. Technol. 2020 57 1579 1585 10.1007/s13197-020-04262-3
Kermanshahi R.K. Khaniki G.J. Goudarzi L. Biosorption of Cd+2 and Pb+2 by Exopolysaccharide Extracted from Lactobacillus Fermentum 6b; Adsorption Isotherm and Kinetic Studies Iran. J. Public Health 2023 52 622 632 10.18502/ijph.v52i3.12145
Werning M.L. Hernández-Alcántara A.M. Ruiz M.J. Soto L.P. Dueñas M.T. López P. Frizzo L.S. Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals Foods 2022 11 1284 10.3390/foods11091284
Wang Y. Li C. Liu P. Ahmed Z. Xiao P. Bai X. Physical characterization of exopolysaccharide produced by Lactobacillus plantarum KF5 isolated from Tibet Kefir Carbohydrate Polymers. 2010 82 895 903 10.1016/j.carbpol.2010.06.013
Li M. Li W. Li D. Tian J. Xiao L. Kwok L.-Y. Li W. Sun Z. Structure Characterization, Antioxidant Capacity, Rheological Characteristics and Expression of Biosynthetic Genes of Exopolysaccharides Produced by Lactococcus lactis subsp. Lactis IMAU11823 Food Chem. 2022 384 132566 10.1016/j.foodchem.2022.132566 35247774
Tarique M. Ali A.H. Kizhakkayil J. Gan R.-Y. Liu S.-Q. Kamal-Eldin A. Ayyash M. Investigating the Biological Activities and Prebiotic Potential of Exopolysaccharides Produced by Lactobacillus delbrueckii and Lacticaseibacillus rhamnosus: Implications for Gut Microbiota Modulation and Rheological Properties in Fermented Milk Food Hydrocoll. Health 2023 4 100162 10.1016/j.fhfh.2023.100162
Hu X. Pang X. Wang P.G. Chen M. Isolation and Characterization of an Antioxidant Exopolysaccharide Produced by Bacillus sp. S-1 from Sichuan Pickles Carbohydr. Polym. 2019 204 9 16 10.1016/j.carbpol.2018.09.069
Yang J. Yang H. Recent Development in Se-Enriched Yeast, Lactic Acid Bacteria and Bifidobacteria Crit. Rev. Food Sci. Nutr. 2023 63 411 425 10.1080/10408398.2021.1948818
Kodali V.P. Perali R.S. Sen R. Purification and Partial Elucidation of the Structure of an Antioxidant Carbohydrate Biopolymer from the Probiotic Bacterium Bacillus coagulans RK-02 J. Nat. Prod. 2011 74 1692 1697 10.1021/np1008448
Abdl Aali R.A.K. Al-Sahlany S.T.G. Gellan Gum as a Unique Microbial Polysaccharide: Its Characteristics, Synthesis, and Current Application Trends Gels 2024 10 183 10.3390/gels10030183 38534601
Gniewosz M. Pobiega K. Kraśniewska K. Synowiec A. Chaberek M. Galus S. Characterization and Antifungal Activity of Pullulan Edible Films Enriched with Propolis Extract for Active Packaging Foods 2022 11 2319 10.3390/foods11152319
Nwodo U.U. Green E. Okoh A.I. Bacterial Exopolysaccharides: Functionality and Prospects Int. J. Mol. Sci. 2012 13 14002 14015 10.3390/ijms131114002
Aravamudhan A. Ramos D.M. Nada A.A. Kumbar S.G. Chapter 4—Natural polymers: Polysaccharides and their derivatives for biomedical applications Natural and Synthetic Biomedical Polymers Kumbar S.G. Laurencin C.T. Deng M. Elsevier Oxford, UK 2014 67 89 978-0-12-396983-5
Mocanu G. Mihai D. Dulong V. Picton L. Lecerf D. New Anionic Amphiphilic Thermosensitive Pullulan Derivatives Carbohydr. Polym. 2011 84 276 281 10.1016/j.carbpol.2010.11.034
CP Kelco Ingredients & Products Available online: https://www.cpkelco.com/products/ (accessed on 29 August 2024)
Borschiver S. Vasconcelos R.C. Silva F.C. Freitas G.C. Santos P.E. do Bomfim R.O. Technology Roadmap for Hyaluronic Acid and Its Derivatives Market Biofuels Bioprod. Biorefining 2019 13 435 444 10.1002/bbb.1936
PULLULAN|Research and Development Stories|Research and Development|Nagase Viita Co., Ltd Available online: https://group.nagase.com/viita/en/rd/story/03/ (accessed on 29 August 2024)
Emre Oz Y. Keskin-Erdogan Z. Safa N. Esin Hames Tuna E. A Review of Functionalised Bacterial Cellulose for Targeted Biomedical Fields J. Biomater. Appl. 2021 36 648 681 10.1177/0885328221998033 33673762
Meito Sangyo | Dextrans and Dextran Derivatives Available online: https://www.meito-sangyo.co.jp/kaseihin/index_e/dextran/ (accessed on 29 August 2024)
Dahiya D. Nigam P.S. Dextran of Diverse Molecular-Configurations Used as a Blood-Plasma Substitute, Drug-Delivery Vehicle and Food Additive Biosynthesized by Leuconostoc, Lactobacillus and Weissella Appl. Sci. 2023 13 12526 10.3390/app132212526
Singhvi G. Hans N. Shiva N. Kumar Dubey S. Chapter 5—Xanthan gum in drug delivery applications Natural Polysaccharides in Drug Delivery and Biomedical Applications Hasnain M.S. Nayak A.K. Academic Press Cambridge, MA, USA 2019 121 144 978-0-12-817055-7
Szekalska M. Puciłowska A. Szymańska E. Ciosek P. Winnicka K. Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications Int. J. Polym. Sci. 2016 2016 7697031 10.1155/2016/7697031
Urtuvia V. Maturana N. Acevedo F. Peña C. Díaz-Barrera A. Bacterial Alginate Production: An Overview of Its Biosynthesis and Potential Industrial Production World J. Microbiol. Biotechnol. 2017 33 198 10.1007/s11274-017-2363-x
Feketshane Z. Alven S. Aderibigbe B.A. Gellan Gum in Wound Dressing Scaffolds Polymers 2022 14 4098 10.3390/polym14194098
Muthukumar T. Song J.E. Khang G. Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications Mol. Basel Switz. 2019 24 4514 10.3390/molecules24244514 31835526
Singh R.S. Kaur N. Singh D. Purewal S.S. Kennedy J.F. Pullulan in Pharmaceutical and Cosmeceutical Formulations: A Review Int. J. Biol. Macromol. 2023 231 123353 10.1016/j.ijbiomac.2023.123353
Fallacara A. Baldini E. Manfredini S. Vertuani S. Hyaluronic Acid in the Third Millennium Polymers 2018 10 701 10.3390/polym10070701 30960626
Li Q. Qi X. Zhang Z. Intra-Articular Oxygen-Ozone versus Hyaluronic Acid in Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials Int. J. Surg. 2018 58 3 10 10.1016/j.ijsu.2018.08.007
Gershon R.K. Kondo K. Cell Interactions in the Induction of Tolerance: The Role of Thymic Lymphocytes Immunology 1970 18 723 4911896
Sakaguchi S. Sakaguchi N. Asano M. Itoh M. Toda M. Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor Alpha-Chains (CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases J. Immunol. 1995 155 1151 1164 10.4049/jimmunol.155.3.1151
Kanmani P. Albarracin L. Kobayashi H. Iida H. Komatsu R. Humayun Kober A.K.M. Ikeda-Ohtsubo W. Suda Y. Aso H. Makino S. et al. Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 Modulate Innate Antiviral Immune Response in Porcine Intestinal Epithelial Cells Mol. Immunol. 2018 93 253 265 10.1016/j.molimm.2017.07.009
Makino S. Sato A. Goto A. Nakamura M. Ogawa M. Chiba Y. Hemmi J. Kano H. Takeda K. Okumura K. et al. Enhanced Natural Killer Cell Activation by Exopolysaccharides Derived from Yogurt Fermented with Lactobacillus Delbrueckii ssp. Bulgaricus OLL1073R-1 J. Dairy Sci. 2016 99 915 923 10.3168/jds.2015-10376
Wang J. Wu T. Fang X. Min W. Yang Z. Characterization and Immunomodulatory Activity of an Exopolysaccharide Produced by Lactobacillus Plantarum JLK0142 Isolated from Fermented Dairy Tofu Int. J. Biol. Macromol. 2018 115 985 993 10.1016/j.ijbiomac.2018.04.099
Hougaard A.B. Pindstrup H. Arneborg N. Andersen M.L. Skibsted L.H. Free Radical Formation by Lactobacillus Acidophilus NCFM Is Enhanced by Antioxidants and Decreased by Catalase Food Res. Int. 2016 79 81 87 10.1016/j.foodres.2015.12.003
Hsieh F.-C. Lan C.-C.E. Huang T.-Y. Chen K.-W. Chai C.-Y. Chen W.-T. Fang A.-H. Chen Y.-H. Wu C.-S. Heat-Killed and Live Lactobacillus Reuteri GMNL-263 Exhibit Similar Effects on Improving Metabolic Functions in High-Fat Diet-Induced Obese Rats Food Funct. 2016 7 2374 2388
Azad M.A.K. Sarker M. Wan D. Immunomodulatory effects of probiotics on cytokine profiles BioMed Res. Int. 2018 2018 8063647 10.1155/2018/8063647
Wang A.N. Cai C.J. Zeng X.F. Zhang F.R. Zhang G.L. Thacker P.A. Wang J.J. Qiao S.Y. Dietary Supplementation with L Actobacillus Fermentum I5007 Improves the Anti-oxidative Activity of Weanling Piglets Challenged with Diquat J. Appl. Microbiol. 2013 114 1582 1591
Lu W. Chen S. Lai C. Guo W. Fu L. Andrieu J.-M. Induction of CD8+ Regulatory T Cells Protects Macaques against SIV Challenge Cell Rep. 2012 2 1736 1746 23260669
Xiu L. Zhang H. Hu Z. Liang Y. Guo S. Yang M. Du R. Wang X. Immunostimulatory Activity of Exopolysaccharides from Probiotic Lactobacillus Casei WXD030 Strain as a Novel Adjuvant in Vitro and in Vivo Food Agric. Immunol. 2018 29 1086 1105 10.1080/09540105.2018.1513994
Hongying F. Xianbo W. Fang Y. Yang B. Beiguo L. Oral Immunization with Recombinant Lactobacillus Acidophilus Expressing the Adhesin Hp0410 of Helicobacter Pylori Induces Mucosal and Systemic Immune Responses Clin. Vaccine Immunol. 2014 21 126 132 10.1128/CVI.00434-13 24285819
Marcobal A. Liu X. Zhang W. Dimitrov A.S. Jia L. Lee P.P. Fouts T.R. Parks T.P. Lagenaur L.A. Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human Vaginal Lactobacillus AIDS Res. Hum. Retroviruses 2016 32 964 971 10.1089/aid.2015.0378
Suebwongsa N. Lulitanond V. Mayo B. Yotpanya P. Panya M. Development of an Escherichia coli–Lactobacillus casei Shuttle Vector for Heterologous Protein Expression in Lactobacillus casei Springerplus 2016 5 169 10.1186/s40064-016-1760-1 27026866
Tan T.S. Syed Hassan S. Yap W.B. Expression of Surface-bound Nonstructural 1 (NS 1) Protein of Influenza Virus A H5N1 on Lactobacillus casei Strain C1 Lett. Appl. Microbiol. 2017 64 446 451 10.1111/lam.12738 28370088
Wang J. Fang X. Wu T. Fang L. Liu C. Min W. In Vitro Immunomodulatory Effects of Acidic Exopolysaccharide Produced by Lactobacillus planetarium JLAU103 on RAW264.7 Macrophages Int. J. Biol. Macromol. 2020 156 1308 1315 10.1016/j.ijbiomac.2019.11.169
Yu M. Qi R. Chen C. Yin J. Ma S. Shi W. Wu Y. Ge J. Jiang Y. Tang L. Immunogenicity of Recombinant Lactobacillus casei-expressing F4 (K88) Fimbrial Adhesin FaeG in Conjunction with a Heat-labile Enterotoxin A (LTAK 63) and Heat-labile Enterotoxin B (LTB) of Enterotoxigenic Escherichia Coli as an Oral Adjuvant in Mice J. Appl. Microbiol. 2017 122 506 515 10.1111/jam.13352
Asgher M. Qamar S.A. Iqbal H.M.N. Microbial Exopolysaccharide-Based Nano-Carriers with Unique Multi-Functionalities for Biomedical Sectors Biologia 2021 76 673 685 10.2478/s11756-020-00588-7
Tassa C. Shaw S.Y. Weissleder R. Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy Acc. Chem. Res. 2011 44 842 852 10.1021/ar200084x
Topal M. Arslan Topal E.I. Extracellular polymeric substances in textile industry Sustainable Approaches in Textiles and Fashion: Fibres, Raw Materials and Product Development Muthu S.S. Springer Nature Singapore 2022 23 40 978-981-19087-8-1
Altamira-Algarra B. Rueda E. Lage A. San León D. Martínez-Blanch J.F. Nogales J. García J. Gonzalez-Flo E. New Strategy for Bioplastic and Exopolysaccharides Production: Enrichment of Field Microbiomes with Cyanobacteria New Biotechnol. 2023 78 141 149 10.1016/j.nbt.2023.10.008 37852438
Abou-alfitooh S.A.M. El-hoshoudy A.N. Eco-Friendly Modified Biopolymers for Enhancing Oil Production: A Review J. Polym. Environ. 2024 32 2457 2483 10.1007/s10924-023-03132-1
Gao C. Potential of Welan Gum to Enhance Oil Recovery J. Pet. Explor. Prod. Technol. 2015 5 197 200 10.1007/s13202-014-0135-9
He S. Zhang M. Chen B. Wei X. Su X. Modification of Welan Gum with Poly(2-Oxazoline) to Obtain Thermoviscosifying Polymer for Enhanced Oil Recovery Int. J. Biol. Macromol. 2024 263 130193 10.1016/j.ijbiomac.2024.130193
Sengupta S. Dey S. Microbial Exo-Polysaccharides (EPS): Role in Agriculture and Environment Agric. Food 2019 1 4 8
Costa O.Y.A. Raaijmakers J.M. Kuramae E.E. Microbial Extracellular Polymeric Substances: Ecological Function and Impact on Soil Aggregation Front. Microbiol. 2018 9 1636 10.3389/fmicb.2018.01636
Banerjee A. Sarkar S. Govil T. González-Faune P. Cabrera-Barjas G. Bandopadhyay R. Salem D.R. Sani R.K. Extremophilic Exopolysaccharides: Biotechnologies and Wastewater Remediation Front. Microbiol. 2021 12 721365 10.3389/fmicb.2021.721365
Costa J. Baratto M.C. Spinelli D. Leone G. Magnani A. Pogni R. A Novel Bio-Adhesive Based on Chitosan-Polydopamine-Xanthan Gum for Glass, Cardboard and Textile Commodities Polymers 2024 16 1806 10.3390/polym16131806
Ahmed F. Hutton-Prager B. Xanthan Gum Modification to Surface and Interfacial Properties between Soil-Based Matrixes and Petroleum Oils to Minimize Soil Pollution Appl. Res. 2024 3 e202400096 10.1002/appl.202400096
Fu X. Qin F. Liu T. Zhang X. Enhanced Oil Recovery Performance and Solution Properties of Hydrophobic Associative Xanthan Gum Energy Fuels 2022 36 181 194 10.1021/acs.energyfuels.1c02941
De Melo Teixeira L. da Silva Santos É. dos Santos R.S. Ramos A.V.G. Baldoqui D.C. Bruschi M.L. Gonçalves J.E. Gonçalves R.A.C. de Oliveira A.J.B. Production of Exopolysaccharide from Klebsiella oxytoca: Rheological, Emulsifying, Biotechnological Properties, and Bioremediation Applications Int. J. Biol. Macromol. 2024 278 134400 10.1016/j.ijbiomac.2024.134400
Fortuna B. Logar J. Sorze A. Valentini F. Smolar J. Influence of Xanthan Gum-Based Soil Conditioners on the Geotechnical Properties of Soils Appl. Sci. 2024 14 4044 10.3390/app14104044
Garmasheva I. Tomila T. Kharkhota M. Oleschenko L. Exopolysaccharides of Lactic Acid Bacteria as Protective Agents against Bacterial and Viral Plant Pathogens Int. J. Biol. Macromol. 2024 276 133851 10.1016/j.ijbiomac.2024.133851
Zhao J. Wang Y. Liu Q. Wang Y. Long C. Pullulan-Based Coatings Carrying Biocontrol Yeast Mixed with NaCl to Control Citrus Postharvest Disease Decays Pestic. Biochem. Physiol. 2024 205 106108 10.1016/j.pestbp.2024.106108
Srivastava G.K. Martinez-Rodriguez S. Md Fadilah N.I. Looi Qi Hao D. Markey G. Shukla P. Fauzi M.B. Panetsos F. Progress in Wound-Healing Products Based on Natural Compounds, Stem Cells, and MicroRNA-Based Biopolymers in the European, USA, and Asian Markets: Opportunities, Barriers, and Regulatory Issues Polymers 2024 16 1280 10.3390/polym16091280
Barros De Medeiros V.P. Da Costa W.K.A. Da Silva R.T. Pimentel T.C. Magnani M. Microalgae as Source of Functional Ingredients in New-Generation Foods: Challenges, Technological Effects, Biological Activity, and Regulatory Issues Crit. Rev. Food Sci. Nutr. 2022 62 4929 4950 10.1080/10408398.2021.1879729
