Article (Scientific journals)
Prediction of cognitive decline in healthy aging based on neuropsychiatric symptoms and PET-biomarkers of Alzheimer's disease
Ronat, Lucas; Hanganu, Alexandru; Chylinski, Daphné et al.
2023In Journal of Neurology
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Keywords :
Neurology (clinical); Neurology
Abstract :
[en] Neuropsychiatric symptoms (NPS) have been associated with a risk of accelerated cognitive decline or conversion to dementia of the Alzheimer’s Disease (AD) type. Moreover, the NPS were also associated with higher AD biomarkers (brain tau and amyloid burden) even in non-demented patients. But the effect of the relationship between NPS and biomarkers on cognitive decline has not yet been studied. This work aims to assess the relationship between longitudinal cognitive changes and NPS, specifically depression and anxiety, in association with AD biomarkers in healthy middle-aged to older participants. The cohort consisted of 101 healthy participants aged 50–70 years, 66 of whom had neuropsychological assessments of memory, executive functions, and global cognition at a 2-year follow-up. At baseline, NPS were assessed using the Beck Depression and Anxiety Inventories while brain tau and amyloid loads were measured using positron emission topography. For tau burden, THK5351 uptake is used as a proxy of tau and neuroinflammation. Participants, declining or remaining stable at follow-up, were categorized into groups for each cognitive domain. Group classification was investigated using binary logistic regressions based on combined AD biomarkers and the two NPS. The results showed that an association between anxiety and prefrontal amyloid burden significantly classified episodic memory decline, while the classification of global cognitive decline involved temporal and occipital amyloid burden but not NPS. Moreover, depression together with prefrontal and hippocampal tau burden were associated with a decline in memory. The classification of participants based on executive decline was related to depression and mainly prefrontal tau burden. These findings suggest that the combination of NPS and brain biomarkers of AD predicts the occurrence of cognitive decline in aging.
Disciplines :
Neurosciences & behavior
Author, co-author :
Ronat, Lucas 
Hanganu, Alexandru
Chylinski, Daphné ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Physiology of Cognition
Van Egroo, Maxime
Narbutas, Justinas ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte
Besson, Gabriel ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Muto, Vincenzo  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Schmidt, Christina  ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Département de physique
Phillips, Christophe  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Salmon, Eric ;  Université de Liège - ULiège > Département de physique > S.U.P.R.A.S.
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Vandewalle, Gilles  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie
Bastin, Christine  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
More authors (5 more) Less
Language :
English
Title :
Prediction of cognitive decline in healthy aging based on neuropsychiatric symptoms and PET-biomarkers of Alzheimer's disease
Publication date :
19 December 2023
Journal title :
Journal of Neurology
ISSN :
0340-5354
eISSN :
1432-1459
Publisher :
Springer Science and Business Media LLC
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Mitacs [CA]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FWB - Fédération Wallonie-Bruxelles [BE]
Funding text :
For this project, Lucas Ronat received a grant from the MITACS Globalink program. This work was supported by the Fonds National de la Recherche Scientifique (CS is a research associate, CB and GV are senior research associates, and FC and CP are research directors at the FRS-FNRS) and by the Wallonia-Brussels Federation (Concerted Research Actions – grant 17/21-09 SLEEPDEM).
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