Article (Scientific journals)
Super-responders to anti-IL-5/anti-IL-5R are characterised by high sputum eosinophil counts at baseline.
Gerday, Sara; Graff, Sophie; Moermans, Catherine et al.
2023In Thorax, p. 2022-219781
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Keywords :
Asthma; Pulmonary and Respiratory Medicine
Abstract :
[en] Several clinical trials have demonstrated that anti-IL-5(R) biologics were able to improve lung function, asthma control and chronic oral corticosteroid exposure and reduce exacerbations among eosinophilic asthmatic patients. However, a certain variability in clinical responses to anti-IL-5(R) biologics was brought to light. Our study aimed at evaluating the role of baseline sputum eosinophils in identifying super-responders to mepolizumab and benralizumab. Our study reinforces the importance to examine sputum eosinophils in patients suffering from severe asthma before starting a biologic as it is associated with the intensity of response to mepolizumab and benralizumab.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Gerday, Sara  ;  Université de Liège - ULiège > GIGA
Graff, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Moermans, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
GUISSARD, Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
PAULUS, Virginie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Henket, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Schleich, FLorence ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Language :
English
Title :
Super-responders to anti-IL-5/anti-IL-5R are characterised by high sputum eosinophil counts at baseline.
Publication date :
01 September 2023
Journal title :
Thorax
ISSN :
0040-6376
eISSN :
1468-3296
Publisher :
BMJ, England
Pages :
thorax-2022-219781
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 04 October 2023

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