Article (Scientific journals)
Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study
Pincemail, Joël; Tchana-Sato, Vincent; Courtois, Audrey et al.
2023In Antioxidants, 12 (5), p. 1106
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Keywords :
Cell Biology; Clinical Biochemistry; Molecular Biology; Biochemistry; Physiology
Abstract :
[en] Background: Thoracic aortic dissection (TAD) is a life-threatening condition which usually occurs on an aneurysmal aortic wall. Although increasing data have shown that inflammation and oxidative stress play an important role in the patho-physiology of dissection, systemic oxidative stress status (OSS) has not been clearly determined in patients suffering from TAD. Methods: A cohort of 115 patients presenting type A or B TAD were admitted to our center from 2013 to 2017. Out of this cohort, 46 patients were included in a study on dissected aorta (LIege study on DIssected Aorta: LIDIA). In 18 out of the 46 patients, systemic OSS parameters were evaluated after TAD diagnosis by determination of eight different antioxidants, four trace elements, two markers of oxidative lipid damage and two inflammatory markers. Results: The 18 TAD patients included 10 men and 8 women (median age: 62 years; interquartile range: 55–68) diagnosed with type A (N = 8) or B (N = 10) TAD. Low plasma levels of vitamin C, β-carotene, γ-tocopherol, thiol proteins, paraoxonase and selenium were observed in these 18 patients. By contrast, the concentration of copper and total hydroperoxides, copper/zinc ratio, as well as inflammatory markers, were higher than the reference intervals. No difference was observed in oxidative stress biomarker concentrations between type A and B TAD patients. Conclusions: This pilot study, limited to 18 TAD patients, revealed a heightened systemic OSS, determined at 15.5 days (median) after the initial diagnosis, in those TAD patients without complications (malperfusion syndrome and aneurysm formation). Larger studies on biological fluids are needed to better characterize the oxidative stress and interpret its consequence in TAD disease.
Disciplines :
Cardiovascular & respiratory systems
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Pincemail, Joël  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
Tchana-Sato, Vincent   ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Courtois, Audrey;  CHC Montlegia, Onco-Hematology, 4000 Liège, Belgium
MUSUMECI, Lucia  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
CHERAMY-BIEN, Jean-Paul  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Munten, Jacobine ;  Centre Hospitalier Universitaire de Liège - CHU > > Gestion des séjours patients
Labropoulos, Nicos;  Department of Surgery, Stony Brook University Hospital, Stony Brook, NY 11794-8191, USA
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Sakalihasan, Natzi  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
 These authors have contributed equally to this work.
Language :
English
Title :
Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study
Publication date :
16 May 2023
Journal title :
Antioxidants
eISSN :
2076-3921
Publisher :
MDPI AG
Volume :
12
Issue :
5
Pages :
1106
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fonds pour la Chirurgie Cardiaque, Belgium [BE]
Aneurysmal Pathology Foundation [BE]
Funding number :
Medtronic, BeLux, Research Grant, Belgium
Available on ORBi :
since 19 June 2023

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