[en] Background: Thoracic aortic dissection (TAD) is a life-threatening condition which usually occurs on an aneurysmal aortic wall. Although increasing data have shown that inflammation and oxidative stress play an important role in the patho-physiology of dissection, systemic oxidative stress status (OSS) has not been clearly determined in patients suffering from TAD. Methods: A cohort of 115 patients presenting type A or B TAD were admitted to our center from 2013 to 2017. Out of this cohort, 46 patients were included in a study on dissected aorta (LIege study on DIssected Aorta: LIDIA). In 18 out of the 46 patients, systemic OSS parameters were evaluated after TAD diagnosis by determination of eight different antioxidants, four trace elements, two markers of oxidative lipid damage and two inflammatory markers. Results: The 18 TAD patients included 10 men and 8 women (median age: 62 years; interquartile range: 55–68) diagnosed with type A (N = 8) or B (N = 10) TAD. Low plasma levels of vitamin C, β-carotene, γ-tocopherol, thiol proteins, paraoxonase and selenium were observed in these 18 patients. By contrast, the concentration of copper and total hydroperoxides, copper/zinc ratio, as well as inflammatory markers, were higher than the reference intervals. No difference was observed in oxidative stress biomarker concentrations between type A and B TAD patients. Conclusions: This pilot study, limited to 18 TAD patients, revealed a heightened systemic OSS, determined at 15.5 days (median) after the initial diagnosis, in those TAD patients without complications (malperfusion syndrome and aneurysm formation). Larger studies on biological fluids are needed to better characterize the oxidative stress and interpret its consequence in TAD disease.
Disciplines :
Cardiovascular & respiratory systems Human health sciences: Multidisciplinary, general & others
Author, co-author :
Pincemail, Joël ✱; Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
Tchana-Sato, Vincent ✱; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
LePage M.A. Quint L.E. Sonnad S.S. Deeb G.M. Williams D.M. Aortic Dissection: CT Features That Distinguish True Lumen from False Lumen Am. J. Roentgenol. 2001 177 207 211 10.2214/ajr.177.1.1770207 11418429
Nienaber C.A. Clough R.E. Sakalihasan N. Suzuki T. Gibbs R. Mussa F. Jenkins M.P. Thompson M.M. Evangelista A. Yeh J.S. et al. Aortic dissection Nat. Rev. Dis. Primers 2016 2 16053 10.1038/nrdp.2016.53 27440162
Howard D.P.J. Banerjee A. Fairhead J.F. Perkins J. Silver L.E. Rothwell P.M. Population-Based Study of Incidence and Outcome of Acute Aortic Dissection and Premorbid Risk Factor Control: 10-Year Results From the Oxford Vascular Study Circulation 2013 127 2031 2037 10.1161/CIRCULATIONAHA.112.000483
Wu D. Shen Y.H. Russell L. Coselli J.S. LeMaire S.A. Molecular Mechanisms of Thoracic Aortic Dissection J. Surg. Res. 2013 184 907 924 10.1016/j.jss.2013.06.007 23856125
Wu D. Choi J.C. Sameri A. Minard C.G. Coselli J.S. Shen Y.H. LeMaire S.A. Inflammatory Cell Infiltrates in Acute and Chronic Thoracic Aortic Dissection Aorta 2013 1 259 267 10.12945/j.aorta.2013.13-044 26798703
Quintana R.A. Taylor W.R. Cellular Mechanisms of Aortic Aneurysm Formation Circ. Res. 2019 124 607 618 10.1161/CIRCRESAHA.118.313187
Sakalihasan N. Nienaber C.A. Hustinx R. Lovinfosse P. El Hachemi M. Cheramy-Bien J.-P. Seidel L. Lavigne J.-P. Quaniers J. Kerstenne M.-A. et al. (Tissue PET) Vascular Metabolic Imaging and Peripheral Plasma Biomarkers in the Evolution of Chronic Aortic Dissections Eur. Heart J. Cardiovasc. Imaging 2015 16 626 633 10.1093/ehjci/jeu283
Pincemail J. Defraigne J.O. Cheramy–Bien J.P. Dardenne N. Donneau A.F. Albert A. Labropoulos N. Sakalihasan N. On the Potential Increase of the Oxidative Stress Status in Patients with Abdominal Aortic Aneurysm Redox Rep. 2012 17 139 144 10.1179/1351000212Y.0000000012
Branchetti E. Poggio P. Sainger R. Shang E. Grau J.B. Jackson B.M. Lai E.K. Parmacek M.S. Gorman R.C. Gorman J.H. et al. Oxidative Stress Modulates Vascular Smooth Muscle Cell Phenotype via CTGF in Thoracic Aortic Aneurysm Cardiovasc. Res. 2013 100 316 324 10.1093/cvr/cvt205
Pisano C. Benedetto U. Ruvolo G. Balisteri C.R. Oxidative stress in the pathogenesis of aorta diseases as source of potential biomarkers and therapeutic targets, with a particular focus on ascending aorta aneurysms Antioxidants 2022 11 182 10.3390/antiox11020182
Portelli S.S. Hambly B.D. Jeremy R.W. Robertson E.N. Oxidative Stress in Genetically Triggered Thoracic Aortic Aneurysm: Role in Pathogenesis and Therapeutic Opportunities Redox Rep. 2021 26 45 52 10.1080/13510002.2021.1899473 33715602
Pisano C. Ruvolo G. Balisteri C.R. Oxidative stress inside the pathogenesis of ascending aorta aneurysms: A clearer vision for identtifying promising biomarkers and therapeutic targets Antioxidants 2022 11 182 10.3390/antiox11020182 35204065
Flieger J. Flieger W. Baj J. Maciejewski R. Antioxidants: Classification, natural Sources, activity/Capacity measurements, and usefulness for the synthesis of nanoparticles Materials 2021 14 4135 10.3390/ma14154135
Soto M.E. Soria-Castro E. Guarner-Lans V.G. Muruato-Ontiveros E.M. Mejia B.I.H. Hernandez H.J.M. Garcia R. Herrera V. Perez-Torres I. Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies Oxidative Med. Cell. Longev. 2014 2014 760694 10.1155/2014/760694
Billaud M. Philippi J.A. Kotlarczyk M.P. Hill J.C. Ellis B.W. St Croix C.M. Cantu-Medélin N. Kelley E.E. Gleason T.G. Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve J. Thorac. Cardiovasc. Surg. 2017 154 1756 1762 10.1016/j.jtcvs.2017.05.065
Philippi J.A. Hill J.C. Green B.R. Kotlarczyk M.P. Gleason T.G. Bicuspid aortic valve morphotype correlates with regional antioxidant gene expression profiles in the proximal ascending aorta Ann. Thorac. Surg. 2017 104 79 87 10.1016/j.athoracsur.2016.10.039
Soto M.E. Manzano-Pech L.G. Guarner-Lans V. Diaz-Galindo J.A. Vasquez X. Casrejon-Tellez V. Gamboa R. Huesca C. Fuentevilla-Alvarez G. Perez-Torres I. Oxidant/antioxidant profile in the thoracic aneurysm of patients with the Loeys-Dietz syndrome Oxidative Med. Cell. Longev. 2020 2020 5392454 10.1155/2020/5392454
Rysz J. Gluba-Brzozka A. Rokicki R. Franczyk B. Oxidative stress-related susceptibility to aneurysm in Marfan’s syndrome Biomedicines 2021 9 117 10.3390/biomedicines9091171
Liao M. Liu Z. Bao J. Zhao Z. Hu J. Feng X. Feng R. Lu Q. Mei Z. Liu Y. et al. A Proteomic Study of the Aortic Media in Human Thoracic Aortic Dissection: Implication for Oxidative Stress J. Thorac. Cardiovasc. Surg. 2008 136 65 72.e3 10.1016/j.jtcvs.2007.11.017
Fiorillo C. Becatti M. Attanasio M. Lucarni L. Nassi N. Evangelisti I. Porciani M.C. Nassi P. Gensini G.F. Abbate R. et al. Evidence of oxidative stress in plasma of patients with Marfan syndrome Int. J. Cardiol. 2010 145 544 546 10.1016/j.ijcard.2010.04.077 20537738
Irace F.G. Cammisotto V. Valenti V. Forte M. Schirone L. Bartimoccia S. Iaccarino A. Peruzzi M. Schiavon S. Morelli A. et al. Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms J. Am. Coll. Cardiol. Basic Transl. Sci. 2021 6 719 730 10.1016/j.jacbts.2021.08.002 34754985
Pincemail J. Cavalier E. Charlier C. Cheramy–Bien J.-P. Brevers E. Courtois A. Fadeur M. Meziane S. Goff C.L. Misset B. et al. Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study Antioxidants 2021 10 257 10.3390/antiox10020257 33562403
Pincemail J. Rousseau A.-F. Kaux J.-F. Cheramy-Bien J.-P. Bruyère C. Prick J. Stern D. Kaci M.-M. De Noordhout B.M. Albert A. et al. Determination of Redox Status in surviving COVID-19 patients during their recovery in a rehabilitation facility. Potential use of the electrochemical PAOT® technology. A Pilot Study Biomedicines 2023 11 1308 10.3390/biomedicines11051308
Maury J. Gouzi F. De Rigal P. Heraud N. Pincemail J. Molinari N. Pomiès P. Laoudj-Chenivesse D. Mercier J. Préfaut C. et al. Heterogeneity of systemic oxidative stress profiles in COPD: A potential role of gender Oxidative Med. Cell. Longev. 2015 2015 201843 10.1155/2015/201843
Turki A. Hayot M. Carnac G. Pillard F. Passerieux E. Bommart S. de Mauverger E.R. Hugon G. Pincemail J. Pietri S. et al. Functional Muscle Impairment in Facioscapulohumeral Muscular Dystrophy Is Correlated with Oxidative Stress and Mitochondrial Dysfunction Free Radic. Biol. Med. 2012 53 1068 1079 10.1016/j.freeradbiomed.2012.06.041
Pincemail J. Le Goff C. Charlier C. Gillion P. Cheramy-Bien J.-P. Van Honacker E. Chapelle J.-P. Defraigne J.-O. Evaluation biologique du stress oxydant. Application en routine clinique Nutr. Endocrinol. 2010 16 31
Pincemail J. Christelbach S. Gillain S. Ricour C. Dardenne N. Cheramy-Bien J.-P. Defraigne J.-O. Petermans J. Oxidative stress or not in healty older subjects Proceedings of the OCC Meeting 2015, Poster P61 Valencia, Spain 24–26 June 2015
Siegel S. Castellan N.J. Nonparametric Statistics for the Behavioral Sciences 2nd ed. McGraw-Hill Boston, MA, USA 2003
Spiegel M.R. Lindstrom D.P. Schaum’s Easy Outlines: Statistics: Based on Schaum’s Outline of Theory and Problems of Statistics Schaum’s Outline Series McGraw-Hill New York, NY, USA 2000
Gey K.F. Optimum Plasma Levels of Antioxidant Micronutrients. Ten years of antioxidant hypothesis on arteriosclerosis Bibl. Nutr. Dieta 1994 51 84 99 10.1159/000423787
Sánchez-Rodríguez M.A. Mendoza-Núñez V.M. Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans Oxidative Med. Cell. Longev. 2019 2019 4128152 10.1155/2019/4128152
Lindblad M. Tveden-Nyborg P. Lykkesfeldt J. Regulation of Vitamin C Homeostasis during Deficiency Nutrients 2013 5 2860 2879 10.3390/nu5082860 23892714
Turell L. Radi R. Alvarez B. The Thiol Pool in Human Plasma: The Central Contribution of Albumin to Redox Processes Free Radic. Biol. Med. 2013 65 244 253 10.1016/j.freeradbiomed.2013.05.050 23747983
Lubos E. Loscalzo J. Handy D.E. Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities Antioxid. Redox Signal. 2011 15 1957 1997 10.1089/ars.2010.3586
She Z.-G. Chen H.-Z. Yan Y. Li H. Liu D.-P. The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis Antioxid. Redox Signal. 2012 16 597 632 10.1089/ars.2010.3774
Abelló D. Sancho E. Camps J. Joven J. Exploring the Role of Paraoxonases in the Pathogenesis of Coronary Artery Disease: A Systematic Review Int. J. Mol. Sci. 2014 15 20997 21010 10.3390/ijms151120997
Hill A. Borgs C. Fitzner C. Stoppe C. Perioperative vitamin C and E levels in cardiac surgery patients and their clinical significance Nutrients 2019 11 2157 10.3390/nu11092157
Rodemeister S. Duquesne M. Adolph M. Nohr D. Biesalski H.K. Unertl K. Massive and long-fasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation Nutrition 2014 30 673 678 10.1016/j.nut.2013.10.026 24631388
Hill A. Clasen K.C. Wendt S. Majoros A.G. Stoppe C. Ad-hikari N.K.J. Heyland D.K. Benstoem C. Effects of Vitamin C On Organ Function In Cardiac Surgery Patients: A Systematic Review and Meta-Analysis Nutrients 2019 11 2103 10.3390/nu11092103 31487905
Gaetke L. Copper Toxicity, Oxidative Stress, and Antioxidant Nutrients Toxicology 2003 189 147 163 10.1016/S0300-483X(03)00159-8
Lee S.R. Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems Oxidative Med. Cell. Longev. 2018 2018 9156285 10.1155/2018/9156285
Guo C.-H. Chen P.-C. Yeh M.-S. Hsiung D.-Y. Wang C.-L. Cu/Zn Ratios Are Associated with Nutritional Status, Oxidative Stress, Inflammation, and Immune Abnormalities in Patients on Peritoneal Dialysis Clin. Biochem. 2011 44 275 280 10.1016/j.clinbiochem.2010.12.017 21223959
Guo C.-H. Wang C.-L. Effects of Zinc Supplementation on Plasma Copper/Zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients Int. J. Med. Sci. 2013 10 79 89 10.7150/ijms.5291 23289009
Flores-Mateo G. Navas-Acien A. Pastor-Barriuso R. Guallar E. Selenium and Coronary Heart Disease: A Meta-Analysis Am. J. Clin. Nutr. 2006 84 762 773 10.1093/ajcn/84.4.762 17023702
Ito F. Sono Y. Ito T. Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation Antioxidants 2019 8 72 10.3390/antiox8030072
Klein K.M. Jovin I.S. Statins for Patients Undergoing Thoracic Aortic Aneurysm Repair Surgery: What to Do? Aorta 2021 9 169 170 10.1055/s-0041-1736589
Jamialahmadi T. Baratzadeh F. Reiner Ž. Mannarino M.R. Cardenia V. Simental-Mendía L.E. Pirro M. Watts G.F. Sahebkar A. The Effects of Statin Therapy on Oxidized LDL and Its Antibodies: A Systematic Review and Meta-Analysis Oxidative Med. Cell. Longev. 2022 2022 7850659 10.1155/2022/7850659
Ye J. Wang M. Jiang H. Ji Q. Huang Y. Liu J. Zeng T. Xu Y. Wang Z. Lin Y. et al. Increased Levels of Interleukin-22 in Thoracic Aorta and Plasma from Patients with Acute Thoracic Aortic Dissection Clin. Chim. Acta 2018 486 395 401 10.1016/j.cca.2017.10.033
Steven S. Frenis K. Oelze M. Kalinovic S. Kuntic M. Bayo Jimenez M.T. Vujacic-Mirski K. Helmstädter J. Kröller-Schön S. Münzel T. et al. Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease Oxidative Med. Cell. Longev. 2019 2019 7092151 10.1155/2019/7092151
Saxena R. Correlation of Paraoxonase Status with Disease Activity Score and Systemic Inflammation in Rheumatoid Arthritic Patients J. Clin. Diagn. Res. 2016 10 BC01 BC05 10.7860/JCDR/2016/17767.7345
Ran L. Zhao W. Tan X. Wang H. Mizuno K. Takagi K. Zhao Y. Bu H. Association between serum vitamin C and the blood pressure: A systematic review and meta-analysis of observational studies Cardiovasc. Ther. 2020 2020 4940673 10.1155/2020/4940673
Sinclair A.J. Taylor P.B. Lunec J. Girling A.J. Barnett A.H. Low plasma ascorbate levels in patients with type 2 diabetes mellitus consuming adequate dietary vitamin C Diabetes Med. 1994 11 893 898 10.1111/j.1464-5491.1994.tb00375.x 7705029
Giraud D.W. Martin D.H. Driskell J.A. Plasma and dietary vitamin C and E levels in tobacco chewers, smokers and non-smokers J. Am. Diet. Assoc. 1995 6 798 801 10.1016/S0002-8223(95)00220-0 7797811
