Article (Scientific journals)
Increased KL-6 levels in moderate to severe COVID-19 infection.
Cambier, Maureen; Henket, Monique; Frix, Anne-Noëlle et al.
2022In PLoS ONE, 17 (11), p. 0273107
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Keywords :
Fibrinogen; Humans; Retrospective Studies; SARS-CoV-2; Immunologic Tests; COVID-19; Multidisciplinary
Abstract :
[en] ("[en] BACKGROUND: The global coronavirus disease 2019 (COVID-19) has presented significant challenges and created concerns worldwide. Besides, patients who have experienced a SARS-CoV-2 infection could present post-viral complications that can ultimately lead to pulmonary fibrosis. Serum levels of Krebs von den Lungen 6 (KL-6), high molecular weight human MUC1 mucin, are increased in the most patients with various interstitial lung damage. Since its production is raised during epithelial damages, KL-6 could be a helpful non-invasive marker to monitor COVID-19 infection and predict post-infection sequelae. METHODS: We retrospectively evaluated KL-6 levels of 222 COVID-19 infected patients and 70 healthy control. Serum KL-6, fibrinogen, lactate dehydrogenase (LDH), platelet-lymphocytes ratio (PLR) levels and other biological parameters were analyzed. This retrospective study also characterized the relationships between serum KL-6 levels and pulmonary function variables. RESULTS: Our results showed that serum KL-6 levels in COVID-19 patients were increased compared to healthy subjects (470 U/ml vs 254 U/ml, P <0.00001). ROC curve analysis enabled us to identify that KL-6 > 453.5 U/ml was associated with COVID-19 (AUC = 0.8415, P < 0.0001). KL-6 level was positively correlated with other indicators of disease severity such as fibrinogen level (r = 0.1475, P = 0.0287), LDH level (r = 0,31, P = 0,004) and PLR level (r = 0.23, P = 0.0005). However, KL-6 levels were not correlated with pulmonary function tests (r = 0.04, P = 0.69). CONCLUSIONS: KL-6 expression was correlated with several disease severity indicators. However, the association between mortality and long-term follow-up outcomes needs further investigation. More extensive trials are required to prove that KL-6 could be a marker of disease severity in COVID-19 infection.","[en] ","")
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Cambier, Maureen  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Henket, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Frix, Anne-Noëlle ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Gofflot, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > > Biothèque Hospitalo-Universitaire de Liège (BHUL)
THYS, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Tomasetti, Sara;  Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy
Peired, Anna ;  Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy
Struman, Ingrid  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Molecular Angiogenesis Laboratory
Rousseau, Anne-Françoise  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Misset, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Darcis, Gilles  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
Moutschen, Michel  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Njock, Makon-Sébastien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Cavalier, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
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Language :
English
Title :
Increased KL-6 levels in moderate to severe COVID-19 infection.
Publication date :
2022
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science (PLoS), United States
Volume :
17
Issue :
11
Pages :
e0273107
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Leon Fredericq Foundation [BE]
Funding text :
European Union’s Horizon 2020 research and innovation program and EFPIA; Innovative Medicines Initiative 2 Joint Undertaking
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