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Njock Makon-Sébastien

GIGA Immunobiology - Pneumology

See author's contact details
ORCID
0000-0001-8137-1978
Main Referenced Co-authors
Louis, Renaud  (27)
Guiot, Julien  (26)
Henket, Monique  (22)
Struman, Ingrid  (15)
Moermans, Catherine  (14)
Main Referenced Keywords
Humans (11); Biomarkers (5); asthma (4); Breathomics (4); Cell Biology (4);
Main Referenced Unit & Research Centers
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège (2)
CHU (1)
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (1)
GIGA I3-Pneumology - ULiège (1)
GIGA-CME - GIGA Cancer-Cellular and Molecular Epigenetics - ULiège (1)
Main Referenced Disciplines
Cardiovascular & respiratory systems (28)
Biochemistry, biophysics & molecular biology (10)
Oncology (5)
Chemistry (3)
Immunology & infectious disease (2)

Publications (total 52)

The most downloaded
1493 downloads
Moermans, C., Graff, S., Gerday, S., Schleich, F., Guiot, J., Njock, M.-S., & Louis, R. (2022). LES PROBIOTIQUES DANS LE TRAITEMENT DE L’ASTHME. Revue Médicale de Liège, 77 (5-6), 285 - 288. https://hdl.handle.net/2268/297896

The most cited

3196 citations (OpenAlex)

Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., ... Witwer, K. W. (February 2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13 (2), 12404. doi:10.1002/jev2.12404 https://hdl.handle.net/2268/314438

The most significant

Guiot, J., André, B., Potjewijd, J., JACQUERIE, P., Cremers, S., Henket, M., Idoufkir, L., Remacle, C., Tobal, R., GILTAY, L., Moermans, C., GESTER, F., Polese, B., Hamaïdia, M., Struman, I., Louis, E., Malaise, M., de Seny, D., van Paassen, P., ... Njock, M.-S. (2025). Association of fibrotic-related extracellular vesicle microRNAs with lung involvement in systemic sclerosis. European Respiratory Journal, 2400276. doi:10.1183/13993003.00276-2024
Peer Reviewed verified by ORBi

Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., ... Witwer, K. W. (February 2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13 (2), 12404. doi:10.1002/jev2.12404
Peer Reviewed verified by ORBi

NJOCK, M.-S.* , O'Grady, T.* , Nivelles, O., Lion, M., Jacques, S., Cambier, M., Herkenne, S., Muller, F., Christian, A., REMACLE, C., GUIOT, J., Rahmouni, S., Dequiedt, F.* , & Struman, I.*. (June 2022). Endothelial extracellular vesicles promote tumour growth by tumour-associated macrophage reprogramming. Journal of Extracellular Vesicles, 11 (6), 12228. doi:10.1002/jev2.12228
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

GUIOT, J., Cambier, M., Boeckx, A., HENKET, M., Nivelles, O., GESTER, F., LOUIS, E., MALAISE, M., Dequiedt, F., LOUIS, R., Struman, I.* , & NJOCK, M.-S.*. (05 August 2020). Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p. Thorax, 75 (10), 870-881. doi:10.1136/thoraxjnl-2019-214077
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Njock, M.-S., Cheng, H. S., Dang, L. T., Nazari-Jahantigh, M., Lau, A. C., Boudreau, E., Roufaiel, M., Cybulsky, M. I., Schober, A., & Fish, J. E. (14 May 2015). Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood, 125 (20), 3202-12. doi:10.1182/blood-2014-11-611046
Peer Reviewed verified by ORBi


Articles in scientific journals as first or last author

Guiot, J., André, B., Potjewijd, J., JACQUERIE, P., Cremers, S., Henket, M., Idoufkir, L., Remacle, C., Tobal, R., GILTAY, L., Moermans, C., GESTER, F., Polese, B., Hamaïdia, M., Struman, I., Louis, E., Malaise, M., de Seny, D., van Paassen, P., ... Njock, M.-S. (2025). Association of fibrotic-related extracellular vesicle microRNAs with lung involvement in systemic sclerosis. European Respiratory Journal, 2400276. doi:10.1183/13993003.00276-2024
Peer Reviewed verified by ORBi

Guiot, J., & Njock, M.-S. (01 September 2023). Editorial: Progressive fibrosing interstitial lung disease: from bench to bedside. Frontiers in Medicine, 10. doi:10.3389/fmed.2023.1277909
Peer Reviewed verified by ORBi

Guiot, J., Henket, M., Remacle, C., Cambier, M., Struman, I., Winandy, M.-L., Moermans, C., Louis, E., Malaise, M., Ribbens, C., Louis, R., & Njock, M.-S. (15 April 2023). Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis. Respiratory Research, 24 (1), 112. doi:10.1186/s12931-023-02413-6
Peer Reviewed verified by ORBi

NJOCK, M.-S.* , O'Grady, T.* , Nivelles, O., Lion, M., Jacques, S., Cambier, M., Herkenne, S., Muller, F., Christian, A., REMACLE, C., GUIOT, J., Rahmouni, S., Dequiedt, F.* , & Struman, I.*. (June 2022). Endothelial extracellular vesicles promote tumour growth by tumour-associated macrophage reprogramming. Journal of Extracellular Vesicles, 11 (6), 12228. doi:10.1002/jev2.12228
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

O'Grady, T.* , NJOCK, M.-S.* , Lion, M., Bruyr, J., Mariavelle, E., Galvan, B., Boeckx, A., Struman, I.* , & Dequiedt, F.*. (24 March 2022). Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels. BMC Biology, 20 (1), 72. doi:10.1186/s12915-022-01277-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Veitch, S.* , Njock, M.-S.* , Chandy, M.* , Siraj, M. A., Chi, L., Mak, H., Yu, K., Rathnakumar, K., Perez-Romero, C. A., Chen, Z., Alibhai, F. J., Gustafson, D., Raju, S., Wu, R., Zarrin Khat, D., Wang, Y., Caballero, A., Meagher, P., Lau, E., ... Fish, J. E. (February 2022). MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes. Cardiovascular Diabetology, 21 (1), 31. doi:10.1186/s12933-022-01458-z
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Parzibut, G., Henket, M., Moermans, C., Struman, I., Louis, E., Malaise, M., Louis, R., Misset, B., NJOCK, M.-S.* , & Guiot, J.*. (2021). A Blood Exosomal miRNA Signature in Acute Respiratory Distress Syndrome. Frontiers in Molecular Biosciences, 8, 640042. doi:10.3389/fmolb.2021.640042
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

GUIOT, J., Cambier, M., Boeckx, A., HENKET, M., Nivelles, O., GESTER, F., LOUIS, E., MALAISE, M., Dequiedt, F., LOUIS, R., Struman, I.* , & NJOCK, M.-S.*. (05 August 2020). Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p. Thorax, 75 (10), 870-881. doi:10.1136/thoraxjnl-2019-214077
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

GUIOT, J., Struman, I., Louis, E., Louis, R., Malaise, M., & Njock, M.-S. (2019). Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets. Journal of Clinical Medicine, 8 (9). doi:10.3390/jcm8091345
Peer Reviewed verified by ORBi

Njock, M.-S., GUIOT, J., HENKET, M., Nivelles, O., Thiry, M., Dequiedt, F., Corhay, J.-L., Louis, R., & Struman, I. (2018). Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis. Thorax. doi:10.1136/thoraxjnl-2018-211897
Peer Reviewed verified by ORBi

Njock, M.-S., Cheng, H. S., Dang, L. T., Nazari-Jahantigh, M., Lau, A. C., Boudreau, E., Roufaiel, M., Cybulsky, M. I., Schober, A., & Fish, J. E. (14 May 2015). Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood, 125 (20), 3202-12. doi:10.1182/blood-2014-11-611046
Peer Reviewed verified by ORBi

Njock, M.-S., Fouchier, F., Seree, E., Villard Pierre, H., Landrier Jean, F., Pechere, L., Barra, Y., & Champion, S. (07 May 2014). Lycopene modulates THP1 and Caco2 cells inflammatory state through transcriptional and nontranscriptional processes. Mediators of Inflammation, 2014, 507272. doi:10.1155/2014/507272
Peer Reviewed verified by ORBi

Simoncini, S.* , Njock, M.-S.* , Robert, S., Camoin-Jau, L., Sampol, J., Harle, J.-R., Nguyen, C., Dignat-George, F., & Anfosso, F. (23 April 2009). TRAIL/Apo2L mediates the release of procoagulant endothelial microparticles induced by thrombin in vitro: a potential mechanism linking inflammation and coagulation. Circulation Research, 104 (8), 943-51. doi:10.1161/CIRCRESAHA.108.183285
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Articles in scientific journals as co-author

Moermans, C.* , Sabbe, M.* , ONSSELS, A., Bricmont, N., Bonhiver, R., REGNIER, F., Graff, S., Gerday, S., Njock, M.-S., Rosu, A., PAULUS, V., GUISSARD, F., ZIANT, S., SANCHEZ, C., Ernst, M., Desmet, C., Louis, R., & Schleich, F. (2025). Dupilumab Effectiveness in Biologic-Naïve and Switched Severe Asthma in Real Life. Allergy. doi:10.1111/all.70205
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Puttemans, J.* , Brammerloo, Y.* , Blibek, K., Blavier, J., Ntombela, T., Van Molle, I., Joseph, J., Olivet, J., Saha, D., Degey, M., Hamaïdia, M., Jain, P., Geraldine, P., Zimmermann, P., Kim, D.-K., Baiwir, D., Njock, M.-S., Dequiedt, F., Salehi-Ashtiani, K., ... Maseko, S. B.*. (August 2025). Inhibitors of Tax1-PDZ Interactions Block HTLV-1 Viral Transmission by Changing EV Composition. Journal of Extracellular Vesicles, 14 (8), 70137. doi:10.1002/jev2.70137
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Moermans, C., Decerf, N., JAVAUX, N., ONSSELS, A., Bricmont, N., Bonhiver, R., REGNIER, F., Rosu, A., Graff, S., Gerday, S., Njock, M.-S., PAULUS, V., GUISSARD, F., ZIANT, S., SANCHEZ, C., Louis, R., & Schleich, F. (July 2025). High local type-2 inflammation is linked to response in severe asthma treated with anti-Interleukin-5 receptor. Respiratory Medicine, 243, 108151. doi:10.1016/j.rmed.2025.108151
Peer Reviewed verified by ORBi

Moermans, C.* , Schleich, F.* , Gerday, S., Bricmont, N., Bonhiver, R., Graff, S., ZIANT, S., REGNIER, F., Onssels, A., Njock, M.-S., Rosu, A., Henket, M., SANCHEZ, C., PAULUS, V., GUISSARD, F., & Louis, R. (May 2025). The success rate and safety of induced sputum is better than you think: give it a try! ERJ Open Research, 11 (3), 00871-2024. doi:10.1183/23120541.00871-2024
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Polese, B., Ernst, M., Henket, M., Ernst, B., Winandy, M.-L., Njock, M.-S., BLOCKX, C., KOVACS, S., WATAR, F., Peired, A. J., Tomassetti, S., Nardi, C., Gofflot, S., Rahmouni, S., Schofield, J. P., Penrice-Randa, R., Skipp, P. J., Strazzeri, F., Parkinson, E., ... Guiot, J. (2024). Circulating inflammatory cytokines predict severity disease in hospitalized COVID-19 patients: a prospective multicenter study of the European DRAGON consortium. Journal of Infection and Public Health, 102589. doi:10.1016/j.jiph.2024.102589
Peer Reviewed verified by ORBi

Berg, J., Frix, A.-N., Henket, M., GESTER, F., Winandy, M.-L., CANIVET, P., Njock, M.-S., THYS, M., DESIR, C., Meunier, P., Louis, R., Malchair, F., & Guiot, J. (26 September 2024). Long Term Evaluation of Quantitative Cumulative Irradiation in Patients Suffering from ILDs. Diagnostics, 14 (19), 2136. doi:10.3390/diagnostics14192136
Peer Reviewed verified by ORBi

Massenet, T., Potjewijd, J., Tobal, R., GESTER, F., Zanella, D., Henket, M., Njock, M.-S., Dejong, T., Gridelet, G., GILTAY, L., GUISSARD, F., André, B., Ribbens, C., Louis, R., Van Paassen, P., Guiot, J., & Stefanuto, P.-H. (2024). Breathomics to monitor interstitial lung disease associated with systemic sclerosis. ERJ Open Research, 00175-2024. doi:10.1183/23120541.00175-2024
Peer Reviewed verified by ORBi

Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., ... Witwer, K. W. (February 2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13 (2), 12404. doi:10.1002/jev2.12404
Peer Reviewed verified by ORBi

Guiot, J., Henket, M., Ernst, M., Seidel, L., WINANDY, M.-L., DENIS, A., Frix, A.-N., GESTER, F., THYS, M., GILTAY, L., Garah, O., Njock, M.-S., CANIVET, P., Meunier, P., Corhay, J.-L., Regnier, C., Malaise, O., Malaise, M., & Louis, R. (09 March 2023). Airflow obstruction as a marker of adverse prognosis in rheumatoid arthritis. Frontiers in Medicine, 10. doi:10.3389/fmed.2023.1063012
Peer Reviewed verified by ORBi

Beauvois, A.* , Gazon, H.* , Chauhan, P. S., Jamakhani, M., Jacques, J.-R., Thiry, M., Dejardin, E., Di Valentin, E., Twizere, J.-C., Péloponèse, J.-M., Njock, M.-S., Yasunaga, J.-I., Matsuoka, M., Hamaïdia, M.* , & Willems, L.*. (2023). The helicase-like transcription factor redirects the autophagic flux and restricts human T-cell leukemia virus type 1 infection. Proceedings of the National Academy of Sciences of the United States of America, 120 (31), 2216127120. doi:10.1073/pnas.2216127120
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

GUIOT, J., HENKET, M., Frix, A.-N., GESTER, F., THYS, M., GILTAY, L., DESIR, C., MOERMANS, C., NJOCK, M.-S., MEUNIER, P., CORHAY, J.-L., & LOUIS, R. (11 April 2022). Combined obstructive airflow limitation associated with interstitial lung diseases (O-ILD): the bad phenotype ? Respiratory Research, 23 (1), 89. doi:10.1186/s12931-022-02006-9
Peer Reviewed verified by ORBi

Moermans, C., Graff, S., Gerday, S., Schleich, F., Guiot, J., Njock, M.-S., & Louis, R. (2022). LES PROBIOTIQUES DANS LE TRAITEMENT DE L’ASTHME. Revue Médicale de Liège, 77 (5-6), 285 - 288.
Editorial Reviewed verified by ORBi

Cambier, M., Henket, M., Frix, A.-N., Gofflot, S., THYS, M., Tomasetti, S., Peired, A., Struman, I., Rousseau, A.-F., Misset, B., Darcis, G., Moutschen, M., Louis, R., Njock, M.-S., Cavalier, E., & Guiot, J. (2022). Increased KL-6 levels in moderate to severe COVID-19 infection. PLoS ONE, 17 (11), 0273107. doi:10.1371/journal.pone.0273107
Peer Reviewed verified by ORBi

Moermans, C., Damas, K., Guiot, J., NJOCK, M.-S., Corhay, J.-L., Henket, M., Schleich, F., & Louis, R. (April 2021). Sputum IL-25, IL-33 and TSLP, IL-23 and IL-36 in airway obstructive diseases. Reduced levels of IL-36 in eosinophilic phenotype. Cytokine, 140, 155421. doi:10.1016/j.cyto.2021.155421
Peer Reviewed verified by ORBi

Guiot, J., HENKET, M., NJOCK, M.-S., MOERMANS, C., Struman, I., Corhay, J.-L., & Louis, R. (2021). La fibrose pulmonaire : des biomarqueurs à de nouveaux horizons thérapeutiques. Revue Médicale de Liège, 76 (3), 166-172.
Peer reviewed

GUIOT, J., NJOCK, M.-S., ANDRE, B., GESTER, F., HENKET, M., DE SENY, D., MOERMANS, C., MALAISE, M., & LOUIS, R. (2021). Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction. Scientific Reports, 11 (1), 10882. doi:10.1038/s41598-021-90333-0
Peer Reviewed verified by ORBi

Poulet, C., NJOCK, M.-S., MOERMANS, C., LOUIS, E., LOUIS, R., MALAISE, M., & GUIOT, J. (01 May 2020). Exosomal Long Non-Coding RNAs in Lung Diseases. International Journal of Molecular Sciences, 21 (10), 3580. doi:10.3390/ijms21103580
Peer Reviewed verified by ORBi

Guiot, J., HENKET, M., André, B., Herzog, M., Hardat, N., NJOCK, M.-S., MOERMANS, C., Malaise, M., & Louis, R. (2020). A new nucleosomic-based model to identify and diagnose SSc-ILD. Clinical Epigenetics, 12 (1), 124. doi:10.1186/s13148-020-00915-4
Peer Reviewed verified by ORBi

Fish, J. E., Cantu Gutierrez, M., Dang, L. T., Khyzha, N., Chen, Z., Veitch, S., Cheng, H. S., Khor, M., Antounians, L., Njock, M.-S., Boudreau, E., Herman, A. M., Rhyner, A. M., Ruiz, O. E., Eisenhoffer, G. T., Medina-Rivera, A., Wilson, M. D., & Wythe, J. D. (01 July 2017). Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development, 144 (13), 2428-2444. doi:10.1242/dev.146050
Peer Reviewed verified by ORBi

Barker, K. R., Lu, Z., Kim, H., Zheng, Y., Chen, J., Conroy, A. L., Hawkes, M., Cheng, H. S., Njock, M.-S., Fish, J. E., Harlan, J. M., Lopez, J. A., Liles, W. C., & Kain, K. C. (02 February 2017). miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria. Molecular Medicine, 23, 24-33. doi:10.2119/molmed.2016.00139
Peer reviewed

Lacroix, R., Plawinski, L., Robert, S., Doeuvre, L., Sabatier, F., Martinez de Lizarrondo, S., Mezzapesa, A., Anfosso, F., Leroyer, A. S., Poullin, P., Jourde, N., Njock, M.-S., Boulanger, C. M., Angles-Cano, E., & Dignat-George, F. (December 2012). Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis. Haematologica, 97 (12), 1864-72. doi:10.3324/haematol.2012.066167
Peer Reviewed verified by ORBi

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