Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water

Emonds-Alt, Gauthier; Malherbe, Cédric; Kasemiire, Alice; Avohou, Tonakpon Hermane; Hubert, Philippe; Ziemons, Eric; Monbaliu, Jean-Christophe; Eppe, Gauthier

doi:10.1016/j.talanta.2022.123640

Article (Scientific journals)

Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water

Emonds-Alt, Gauthier; Malherbe, Cédric; Kasemiire, Alice et al.

2022 • In Talanta, 249, p. 123640

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/296902

DOI
10.1016/j.talanta.2022.123640

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35716473

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Keywords :

Analytical Chemistry

Abstract :

[en] Glyphosate, also known as N-(phosphonomethyl)glycine, is one of the most widely used herbicides in the world. However, the controversy surrounding the toxicity of glyphosate and its main breakdown product, aminomethylphosphonic acid (AMPA), remains a serious public concern. Therefore, there is a clear need to develop a rapid, sensitive and automated alternative method for the quantification of glyphosate and AMPA. In this context, surface enhanced Raman spectroscopy (SERS) coupled with a microfluidic system for the determination of glyphosate in tap water was developed, optimized and validated. The design of the microfluidic configuration for this application was built constructed to integrate the synthesis of the SERS substrate through to the detection of the analyte. To optimize the microfluidic setup, a design of experiments approach was used to maximize the SERS signal of glyphosate. Subsequently, an approach based on the European guideline document SANTE/11312/2021 was used to validate the method in the range of 78–480 μg/L using the normalized band intensities. The limit of detection and quantification obtained for glyphosate were 40 and 78 μg/L, respectively. Recoveries were in the range 76–117%, while repeatability and intra-day repro- ducibility were ≤17%. Finally, the method was also tested for the determination of AMPA in tap water matrix and for the simultaneous detection of AMPA and glyphosate;

Disciplines :

Chemistry

Author, co-author :

Emonds-Alt, Gauthier ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Malherbe, Cédric ; Université de Liège - ULiège > Molecular Systems (MolSys)

Kasemiire, Alice ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Avohou, Tonakpon Hermane ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Hubert, Philippe ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Ziemons, Eric ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Monbaliu, Jean-Christophe ; Université de Liège - ULiège > Département de chimie (sciences) > Center for Integrated Technology and Organic Synthesis

Eppe, Gauthier ; Université de Liège - ULiège > Molecular Systems (MolSys)

Language :

English

Title :

Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water

Publication date :

03 June 2022

Journal title :

Talanta

ISSN :

0039-9140

eISSN :

1873-3573

Publisher :

Elsevier BV

Volume :

249

Pages :

123640

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0039914022004362?httpAccept=text/xml

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