Article (Scientific journals)
Novel genes and sex differences in COVID-19 severity.
Cruz, Raquel; Almeida, Silvia Diz-de; Heredia, Miguel López et al.
2022In Human Molecular Genetics
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Abstract :
[en] Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥ 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
Disciplines :
Microbiology
Author, co-author :
Cruz, Raquel ;  Centro Nacional de Genotipado (CEGEN), Universidade de Santiago de Compostela, Santiago de Compostela, Spain ; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain ; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Almeida, Silvia Diz-de;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Heredia, Miguel López;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain
Quintela, Inés;  Centro Nacional de Genotipado (CEGEN), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Ceballos, Francisco C;  Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Pita, Guillermo;  Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre, Madrid, Spain
Lorenzo-Salazar, José M;  Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain
González-Montelongo, Rafaela;  Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain
Gago-Domínguez, Manuela;  Fundación Pública Galega de Medicina Xenómica, Sistema Galego de Saúde (SERGAS), Santiago de Compostela, Spain ; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
Porras, Marta Sevilla;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-IDIPAZ, Madrid, Spain
Castaño, Jair Antonio Tenorio;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-IDIPAZ, Madrid, Spain ; ERN-ITHACA-European Reference Network
Nevado, Julian;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-IDIPAZ, Madrid, Spain ; ERN-ITHACA-European Reference Network
Aguado, Jose María;  Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain ; Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0002), Instituto de Salud Carlos III, Madrid, Spain ; School of Medicine, Universidad Complutense, Madrid, Spain ; Centre for Biomedical Network Research on Infectious Diseases, Instituto de Salud Carlos III, Madrid, Spain
Aguilar, Carlos;  Hospital General Santa Bárbara de Soria, Soria, Spain
Aguilera-Albesa, Sergio;  Pediatric Neurology Unit, Department of Pediatrics, Navarra Health Service Hospital, Pamplona, Spain ; Navarra Health Service, Navarra BioMed Research Group, Pamplona, Spain
Almadana, Virginia;  Neumología, Hospital Universitario Virgen Macarena, Seville, Spain
Almoguera, Berta;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Department of Genetics & Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Alvarez, Nuria;  Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre, Madrid, Spain
Andreu-Bernabeu, Álvaro;  Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0002), Instituto de Salud Carlos III, Madrid, Spain ; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain
Arana-Arri, Eunate;  Biocruces Bizkai HRI, Bizkaia, Spain ; Cruces University Hospital, Osakidetza, Bizkaia, Spain
Arango, Celso;  School of Medicine, Universidad Complutense, Madrid, Spain ; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain ; Centre for Biomedical Network Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Arranz, María J;  Fundació Docència I Recerca Mutua Terrassa, Barcelona, Spain
Artiga, Maria-Jesus;  Spanish National Cancer Research Center, CNIO Biobank, Madrid, Spain
Baptista-Rosas, Raúl C;  Hospital General de Occidente, Zapopan Jalisco, Mexico ; Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá Jalisco, Mexico ; Centro de Investigación Multidisciplinario en Salud, Universidad de Guadalajara, Tonalá Jalisco, Mexico
Barreda-Sánchez, María;  Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain ; Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain
Belhassen-Garcia, Moncef;  Servicio de Medicina Interna-Unidad de Enfermedades Infecciosas, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain ; Universidad de Salamanca, Salamanca, Spain
Bezerra, Joao F;  Escola Tecnica de Saúde, Laboratorio de Vigilancia Molecular Aplicada, Brazil
Bezerra, Marcos A C;  Genetics Postgraduate Program, Federal University of Pernambuco, Recife, PE, Brazil
Boix-Palop, Lucía;  Hospital Universitario Mutua Terrassa, Barcelona, Spain
Brion, María ;  Xenética Cardiovascular, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain ; Centre for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain
Brugada, Ramón;  Centre for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain ; Cardiovascular Genetics Center, Institut d'Investigació Biomèdica Girona (IDIBGI), Girona, Spain ; Medical Science Department, School of Medicine, University of Girona, Girona, Spain ; Cardiology Service, Hospital Josep Trueta, Girona, Spain
Bustos, Matilde;  Institute of Biomedicine of Seville (IBiS), Consejo Superior de Investigaciones Científicas (CSIC)- University of Seville- Virgen del Rocio University Hospital, Seville, Spain
Calderón, Enrique J ;  Departemento de Medicina, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain ; Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Biomedicina de Sevilla, Seville, Spain
Carbonell, Cristina;  Universidad de Salamanca, Salamanca, Spain ; Servicio de Medicina Interna, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
Castano, Luis;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Biocruces Bizkai HRI, Bizkaia, Spain ; Osakidetza, Cruces University Hospital, Bizkaia, Spain ; Centre for Biomedical Network Research on Diabetes and Metabolic Associated Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain ; University of Pais Vasco, UPV/EHU, Bizkaia, Spain
Castelao, Jose E;  Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur, Xerencia de Xestion Integrada de Vigo-Servizo Galego de Saúde, Vigo, Spain
Conde-Vicente, Rosa;  Hospital Universitario Río Hortega, Valladolid, Spain
Cordero-Lorenzana, M Lourdes;  Servicio de Medicina intensiva, Complejo Hospitalario Universitario de A Coruña (CHUAC), Sistema Galego de Saúde (SERGAS), A Coruña, Spain
Cortes-Sanchez, Jose L;  Tecnológico de Monterrey, Monterrey, Mexico ; Departament of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, Magdeburg, Germany
Corton, Marta;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Department of Genetics & Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Darnaude, M Teresa;  Unidad de Genética, Hospital Universitario Mostoles, Madrid, Spain
De Martino-Rodríguez, Alba;  Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain ; Instituto Investigación Sanitaria Aragón (IIS-Aragon), Zaragoza, Spain
Campo-Pérez, Victor;  Preventive Medicine Department, Instituto de Investigacion Sanitaria Galicia Sur, Xerencia de Xestion Integrada de Vigo-Servizo Galego de Saúde, Vigo, Spain
Bustamante, Aranzazu Diaz;  Unidad de Genética, Hospital Universitario Mostoles, Madrid, Spain
Domínguez-Garrido, Elena;  Unidad Diagnóstico Molecular, Fundación Rioja Salud, La Rioja, Spain
Luchessi, Andre D;  Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, Brazil
Eirós, Rocío;  Servicio de Cardiología, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
Sanabria, Gladys Mercedes Estigarribia;  Instituto Regional de Investigación en Salud-Universidad Nacional de Caaguazú, Caaguazú, Paraguay
Fariñas, María Carmen;  IDIVAL, Cantabria, Spain ; Universidad de Cantabria, Cantabria, Spain ; Hospital U M Valdecilla, Cantabria, Spain
Fernández-Robelo, Uxía;  Urgencias Hospitalarias, Complejo Hospitalario Universitario de A Coruña (CHUAC), Sistema Galego de Saúde (SERGAS), A Coruña, Spain
Fernández-Rodríguez, Amanda;  Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Fernández-Villa, Tania;  Grupo de Investigación en Interacciones Gen-Ambiente y Salud (GIIGAS) - Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain
Gil-Fournier, Belén;  Unidad de Genética, Hospital Universitario de Getafe, Madrid, Spain
Gómez-Arrue, Javier;  Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain ; Instituto Investigación Sanitaria Aragón (IIS-Aragon), Zaragoza, Spain
Álvarez, Beatriz González;  Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain ; Instituto Investigación Sanitaria Aragón (IIS-Aragon), Zaragoza, Spain
Quirós, Fernan Gonzalez Bernaldo;  Ministerio de Salud Ciudad de Buenos Aires, Buenos Aires, Argentina
González-Peñas, Javier;  Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain ; School of Medicine, Universidad Complutense, Madrid, Spain ; Centre for Biomedical Network Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Gutiérrez-Bautista, Juan F ;  Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain
Herrero, María José;  Plataforma de Farmacogenética, IIS La Fe, Valencia, Spain ; Departamento de Farmacología, Universidad de Valencia, Valencia, Spain
Herrero-Gonzalez, Antonio;  Data Analysis Department, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Jimenez-Sousa, María A;  Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Lattig, María Claudia;  Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia ; SIGEN Alianza Universidad de los Andes - Fundación Santa Fe de Bogotá, Bogotá, Colombia
Borja, Anabel Liger;  Medicina Intensiva, Hospital General de Segovia, Segovia, Spain
Lopez-Rodriguez, Rosario;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Department of Genetics & Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Mancebo, Esther;  Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain ; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Transplant Immunology and Immunodeficiencies Group, Madrid, Spain
Martín-López, Caridad;  Medicina Intensiva, Hospital General de Segovia, Segovia, Spain
Martín, Vicente;  Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain
Martinez-Nieto, Oscar;  SIGEN Alianza Universidad de los Andes - Fundación Santa Fe de Bogotá, Bogotá, Colombia ; Departamento Patologia y Laboratorios, Fundación Santa Fe de Bogota, Bogotá, Colombia
Martinez-Lopez, Iciar;  Unidad de Genética y Genómica Islas Baleares, Islas Baleares, Spain ; Unidad de Diagnóstico Molecular y Genética Clínica, Hospital Universitario Son Espases, Islas Baleares, Spain
Martinez-Resendez, Michel F;  Tecnológico de Monterrey, Monterrey, Mexico
Martinez-Perez, Ángel;  Genomics of Complex Diseases Unit, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain
Mazzeu, Juliana A;  Faculdade de Medicina, Universidade de Brasília, Brazil ; Programa de Pós-Graduação em Ciências Médicas (UnB), Brazil ; Programa de Pós-Graduação em Ciencias da Saude (UnB), Brazil
Macías, Eleuterio Merayo;  Unidad Cuidados Intensivos, Hospital El Bierzo, León, Spain
Minguez, Pablo;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Department of Genetics & Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Cuerda, Victor Moreno;  Medicina Interna, Hospital Universitario Mostoles, Madrid, Spain ; Universidad Francisco de Vitoria, Madrid, Spain
Silbiger, Vivian N;  Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, Brazil
Oliveira, Silviene F;  Programa de Pós-Graduação em Ciencias da Saude (UnB), Brazil ; Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brazil ; Programa de Pós-Graduação em Biologia Animal (UnB), Brazil ; Programa de Pós-Graduação Profissional em Ensino de Biologia (UnB), Brazil
Ortega-Paino, Eva;  Spanish National Cancer Research Center, CNIO Biobank, Madrid, Spain
Parellada, Mara;  School of Medicine, Universidad Complutense, Madrid, Spain ; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain ; Centre for Biomedical Network Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Paz-Artal, Estela;  Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain ; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Transplant Immunology and Immunodeficiencies Group, Madrid, Spain ; Department of Immunology, Ophthalmology and ENT, Universidad Complutense de Madrid, Madrid, Spain
Santos, Ney P C;  Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil
Pérez-Matute, Patricia;  Infectious Diseases, Microbiota and Metabolism Unit, Center for Biomedical Research of La Rioja (CIBIR), Logroño, Spain
Perez, Patricia;  Inditex, A Coruña, Spain
Pérez-Tomás, M Elena;  Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain
Perucho, Teresa;  GENYCA, Madrid, Spain
Pinsach-Abuin, Mel Lina;  Cardiovascular Genetics Center, Institut d'Investigació Biomèdica Girona (IDIBGI), Girona, Spain ; Centre for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain
Pompa-Mera, Ericka N;  Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Instituto Mexicano del Seguro Social (IMSS), Centro Médico Nacional Siglo XXI, Mexico City, Mexico
Porras-Hurtado, Gloria L;  Clinica Comfamiliar Risaralda, Pereira, Colombia
Pujol, Aurora;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Bellvitge Biomedical Research Institute (IDIBELL), Neurometabolic Diseases Laboratory, L'Hospitalet de Llobregat, Spain ; Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain
León, Soraya Ramiro;  Unidad de Genética, Hospital Universitario de Getafe, Madrid, Spain
Resino, Salvador;  Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Fernandes, Marianne R;  Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil ; Departamento de Ensino e Pesquisa, Hospital Ophir Loyola, Belém, Pará, Brazil
Rodríguez-Ruiz, Emilio;  Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain ; Unidad de Cuidados Intensivos, Hospital Clínico Universitario de Santiago (CHUS), Sistema Galego de Saúde (SERGAS), Santiago de Compostela, Spain
Rodriguez-Artalejo, Fernando;  Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain ; Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain ; IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz), Madrid, Spain ; IMDEA-Food Institute, CEI UAM+CSIC, Madrid, Spain
Rodriguez-Garcia, José A;  Complejo Asistencial Universitario de León, León, Spain
Ruiz-Cabello, Francisco;  Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain ; Instituto de Investigación Biosanitaria de Granada (ibs GRANADA), Granada, Spain ; Departamento Bioquímica, Biología Molecular e Inmunología III, Universidad de Granada, Granada, Spain
Ruiz-Hornillos, Javier;  Allergy Unit, Valdemoro, Hospital Infanta Elena, Madrid, Spain ; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain ; Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain
Ryan, Pablo;  Hospital Universitario Infanta Leonor, Madrid, Spain ; Complutense University of Madrid, Madrid, Spain ; Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain
Soria, José Manuel;  Genomics of Complex Diseases Unit, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain
Souto, Juan Carlos;  Haemostasis and Thrombosis Unit, Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain
Tamayo, Eduardo;  Servicio de Anestesiologia y Reanimación, Hospital Clinico Universitario de Valladolid, Valladolid, Spain ; Departamento de Cirugía, Universidad de Valladolid, Valladolid, Spain
Tamayo-Velasco, Alvaro;  Servicio de Hematologia y Hemoterapia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
Taracido-Fernandez, Juan Carlos;  Data Analysis Department, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Teper, Alejandro;  Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina
Torres-Tobar, Lilian;  Sociedad de Cirugía de Bogotá, Hospital de San José, Bogotá, Colombia
Urioste, Miguel;  Familial Cancer Clinical Unit, Spanish National Cancer Research Centre, Madrid, Spain
Valencia-Ramos, Juan;  University Hospital of Burgos, Burgos, Spain
Yáñez, Zuleima;  Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla, Colombia
Zarate, Ruth;  Centro para el Desarrollo de la Investigación Científica, Paraguay
Nakanishi, Tomoko ;  Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland ; Department of Human Genetics, McGill University, Montréal, Québec, Canada ; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada ; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ; Research Fellow, Japan Society for the Promotion of Science, Japan
Pigazzini, Sara;  University of Milano-Bicocca, Milano, Italy ; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
Degenhardt, Frauke ;  Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany ; University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
Butler-Laporte, Guillaume ;  Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada ; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada
Maya-Miles, Douglas;  Digestive Diseases Unit, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain ; Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain
Bujanda, Luis;  Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain ; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
Bouysran, Youssef;  Centre de Génétique Humaine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Palom, Adriana;  Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain ; Departament de Medicina, Universitat Autònoma de Barcelona, Bellatera, Barcelona, Spain ; Liver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain
Ellinghaus, David;  Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany ; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Martínez-Bueno, Manuel;  GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain
Rolker, Selina;  Institute of Human Genetics, University Hospital Bonn, Medical Faculty University of Bonn, Bonn, Germany
Amitrano, Sara;  Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy
Roade, Luisa;  Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain ; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain ; Universitat Autònoma de Barcelona, Departament de Medicina, Bellatera, Barcelona, Spain
Fava, Francesca;  Medical Genetics, University of Siena, Italy ; Azienda Ospedaliero-Universitaria Senese, Genetica Medica, Italy ; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy
Spinner, Christoph D ;  Technical University of Munich, School of Medicine, University Hospital rechts der Isar, Department of Internal Medicine II, Munich, Germany
Prati, Daniele;  Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy
Bernardo, David;  Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain ; Mucosal Immunology Lab, Unidad de Excelencia del Instituto de Biomedicina y Genética Molecular (IBGM, Universidad de Valladolid-CSIC), Valladolid, Spain
Garcia, Federico;  Hospital Universitario Clinico San Cecilio, Granada, Spain ; Instituto de Investigación Ibs.Granada, Granada, Spain
DARCIS, Gilles ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
Fernández-Cadenas, Israel;  Biomedical Research Institute Sant Pau (IIB Sant Pau), Stroke Pharmacogenomics and Genetics Group, Barcelona, Spain
Holter, Jan Cato;  Department of Microbiology, Oslo University Hospital, Oslo, Norway ; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Banales, Jesus M;  Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain ; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), Ikerbasque, San Sebastian, Spain
Frithiof, Robert;  Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden
Duga, Stefano;  Department of Biomedical Sciences, Humanitas University, Milan, Italy ; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Asselta, Rosanna;  Department of Biomedical Sciences, Humanitas University, Milan, Italy ; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Pereira, Alexandre C;  Heart Institute (InCor)/Univ Sao Paulo Med Sch, Sao Paulo, Brazil
Romero-Gómez, Manuel;  Digestive Diseases Unit, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain ; Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain
Nafría-Jiménez, Beatriz;  Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, Clinical Biochemistry Department, San Sebastian, Spain
Hov, Johannes R;  Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Norwegian PSC Research Center and Section of Gastroenterology, Dept Transplantation Medicine, Oslo University Hospital, Oslo, Norway ; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway
Migeotte, Isabelle;  Centre de Génétique Humaine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium ; Fonds de la Recherche Scientifique (FNRS
Renieri, Alessandra ;  Medical Genetics, University of Siena, Italy ; Azienda Ospedaliero-Universitaria Senese, Genetica Medica, Italy ; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy
Planas, Anna M;  Institute for Biomedical Researhc of Barcelona (IIBB), National Spanish Research Council (CSIC), Barcelona, Spain ; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Ludwig, Kerstin U ;  Institute of Human Genetics, University Hospital Bonn, Medical Faculty University of Bonn, Bonn, Germany
Buti, Maria;  Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain ; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain ; Universitat Autònoma de Barcelona, Departament de Medicina, Bellatera, Barcelona, Spain
Rahmouni, Souad  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Alarcón-Riquelme, Marta E;  GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain ; Institute for Environmental Medicine, Karolinska Institutet, Solna, Sweden
Schulte, Eva C;  Institute of Virology, Technical University Munich/Helmholtz Zentrum München, Munich, Germany ; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich University, Munich, Germany ; Department of Psychiatry, University Hospital, LMU Munich University, Munich, Germany
Franke, Andre;  Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany ; University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
Karlsen, Tom H;  Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Norwegian PSC Research Center and Section of Gastroenterology, Dept Transplantation Medicine, Oslo University Hospital, Oslo, Norway ; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway
Valenti, Luca;  Department of Pathopgysiology and Transplantation, Università degli Studi di Milano, Milano, Italy ; Department of Transfusion Medicine and Hematology, Precision Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
Zeberg, Hugo;  Department of Neuroscience, Karolinska Institutet, Sweden ; Max-Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Richards, Brent;  Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada ; Department of Human Genetics, Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada ; King's College London, Department of Twin Research, London, United Kingdom
Ganna, Andrea;  Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland ; Massachusetts General Hospital, Harvard Medical School, Boston, USA
Boada, Mercè;  Research Center and Memory clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain ; Centre for Biomedical Network Research on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain
Rojas, Itziar;  Research Center and Memory clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain ; Centre for Biomedical Network Research on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain
Ruiz, Agustín;  Research Center and Memory clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Spain ; Centre for Biomedical Network Research on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain
Sánchez, Pascual;  CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain
Real, Luis Miguel;  Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain
SCOURGE Cohort Group
HOSTAGE Cohort Group
GRA@CE Cohort Group
Guillen-Navarro, Encarna;  Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain ; Sección Genética Médica - Servicio de Pediatría, Hospital Clínico Universitario Virgen de la Arrixaca, Servicio Murciano de Salud, Murcia, Spain ; Departamento Cirugía, Pediatría, Obstetricia y Ginecología, Facultad de Medicina, Universidad de Murcia (UMU), Murcia, Spain ; Grupo Clínico Vinculado, Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain
Ayuso, Carmen;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Department of Genetics & Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
González-Neira, Anna;  Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre, Madrid, Spain
Riancho, José A;  IDIVAL, Cantabria, Spain ; Universidad de Cantabria, Cantabria, Spain ; Hospital U M Valdecilla, Cantabria, Spain
Rojas-Martinez, Augusto ;  Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico
Flores, Carlos;  Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain ; Research Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain ; Centre for Biomedical Network Research on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Lapunzina, Pablo;  Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-IDIPAZ, Madrid, Spain ; ERN-ITHACA-European Reference Network
Carracedo, Ángel;  Centro Nacional de Genotipado (CEGEN), Universidade de Santiago de Compostela, Santiago de Compostela, Spain ; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain ; Fundación Pública Galega de Medicina Xenómica, Sistema Galego de Saúde (SERGAS), Santiago de Compostela, Spain ; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain ; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
More authors (158 more) Less
Language :
English
Title :
Novel genes and sex differences in COVID-19 severity.
Publication date :
16 June 2022
Journal title :
Human Molecular Genetics
ISSN :
0964-6906
eISSN :
1460-2083
Publisher :
Oxford University Press, Gb
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 June 2022

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