Article (Scientific journals)
Human immune cells express ppMCH mRNA and functional MCHR1 receptor
Verlaet, Myriam; Adamantidis, Antoine; Coumans, Bernard et al.
2002In FEBS Letters, 527 (1-3), p. 205-210
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Keywords :
melanin concentrating hormone; melanin concentrating hormone receptor; immune cells; proliferation; cAMP
Abstract :
[en] Melanin-concentrating hormone (MCH) is highly expressed in the brain and modulates feeding behavior. It is also expressed in some peripheral tissues where its role remains unknown. We have investigated MCH function in human and mouse immune cells. RT-PCR analysis revealed a low expression of prepro-MCH and MCH receptor 1 (MCHR1) but not of MCHR2 transcript in tissular and peripheral blood immune cells. FACS and in vitro assay studies demonstrated that MCHR1 receptor expression on most cell types can trigger, in the presence of MCH, cAMP synthesis and calcium mobilization in peripheral blood mononuclear cells (PBMCs). Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. Accordingly, our data indicate for the first time that MCH and MCHR1 may exert immunomodulatory functions. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Verlaet, Myriam ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)
Adamantidis, Antoine ;  Université de Liège - ULiège > Biochimie et physiologie humaine et pathologique
Coumans, Bernard ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Chanas, G.
Zorzi, Willy ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Heinen, Ernst ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Grisar, Thierry ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Lakaye, Bernard ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Language :
English
Title :
Human immune cells express ppMCH mRNA and functional MCHR1 receptor
Publication date :
11 September 2002
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
527
Issue :
1-3
Pages :
205-210
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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