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Coumans Bernard

GIGA Neurosciences - Molecular Regulation of Neurogenesis

Département des sciences biomédicales et précliniques

See author's contact details
Main Referenced Co-authors
Lakaye, Bernard  (25)
Zorzi, Willy  (18)
Grisar, Thierry  (17)
Heinen, Ernst  (16)
Igout, Ahmed  (15)
Main Referenced Keywords
familial Alzheimer’s disease (fAD), sporadic Alzheimer’s disease (sAD), human pluripotent stem cells (hPSC), brain organoid (3); Microtubules (3); organoids (3); thiamine triphosphate (3); alzheimer's disease (2);
Main Referenced Unit & Research Centers
Giga Neurosciences - ULiège (11)
GIGA Neurosciences-Molecular Regulation of Neurogenesis - ULiège (3)
Service d'Histologie humaine (3)
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (1)
GIGA-Neuroscience (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (20)
Neurology (12)
Anatomy (cytology, histology, embryology...) & physiology (9)
Immunology & infectious disease (4)
Neurosciences & behavior (3)

Publications (total 49)

The most downloaded
7303 downloads
Thellin, O., Zorzi, W., Lakaye, B., De Borman, B., Coumans, B., Hennen, G., Grisar, T., Igout, A., & Heinen, E. (1999). Housekeeping Genes as Internal Standards: Use and Limits. Journal of Biotechnology, 75 (2-3), 291-5. doi:10.1016/S0168-1656(99)00163-7 https://hdl.handle.net/2268/3661

The most cited

1549 citations (OpenAlex)

Thellin, O., Zorzi, W., Lakaye, B., De Borman, B., Coumans, B., Hennen, G., Grisar, T., Igout, A., & Heinen, E. (1999). Housekeeping Genes as Internal Standards: Use and Limits. Journal of Biotechnology, 75 (2-3), 291-5. doi:10.1016/S0168-1656(99)00163-7 https://hdl.handle.net/2268/3661

Cambier, A.* , Masset, G.* , Colinet, M., Ghanavatinejad, F., Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (29 November 2024). Characterization of a transgenic human brain organoid model to study Alzheimer’s disease [Poster presentation]. 8th Annual meeting of the Belgian Society for Stem Cell Research, Bruxelles, Belgium.
* These authors have contributed equally to this work.

Helgueta Romero, S., Masset, G., Colinet, M., Nayila Amdad, Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (12 November 2024). A human brain organoid model to study the role of microglia in Sporadic Alzheimer’s Disease [Poster presentation]. RBSCDB Autumn meeting on Glia, Hasselt, Belgium.

Helgueta Romero, S., Masset, G., Colinet, M., Nayila Amdad, Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (07 June 2024). A human brain organoid model to study the role of microglia in Sporadic Alzheimer’s Disease [Poster presentation]. RBSCDB spring meeting.

Cambier, A.* , Masset, G.* , Colinet, M., Ghanavatinejad, F., Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (07 June 2024). Characterization of a transgenic human brain organoid model to study Alzheimer’s disease [Poster presentation]. Royal Belgian Society for Cell and Developmental Biology Spring Meeting 2024, Leuven, Belgium.
* These authors have contributed equally to this work.

Cambier, A.* , Masset, G.* , Colinet, M., Ghanavatinejad, F., Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (24 November 2023). Characterization of a transgenic human brain organoid model to study Alzheimer’s disease [Poster presentation]. Joint Meeting BeSSCR/RBSCDB.
* These authors have contributed equally to this work.

Helgueta Romero, S., Masset, G., Colinet, M., Nayila Amdad, Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (24 November 2023). A human brain organoid model to study the role of microglia in Sporadic Alzheimer's disease [Poster presentation]. BeSSCR & RBSCDB meeting on cell plasticity.

Colinet, M., Masset, G., Cambier, A., Coumans, B., Nguyen, L., & Espuny Camacho, I. M. (09 June 2023). Modelling human brain maturation and Alzheimer disease using 3D cortical organoids [Poster presentation]. Spring Meeting of the Belgian Society for Cell and Developmental Biology, Liège, Belgium.

Colinet, M., Ghanavatinejad, F., Masset, G., Cambier, A., Helgueta Romero, S., Coumans, B., Engel, D., Nguyen, L., & Espuny Camacho, I. M. (2023). Modelling Human Brain Maturation Using 3D Cortical Organoids [Poster presentation]. BeSSCR/RBSCDB, Brussels, Belgium.

Sambon, M., Gorlova, A., Demelenne, A., Alhama-Riba, J., Coumans, B., Lakaye, B., Wins, P., Fillet, M., Anthony, D. C., Strekalova, T., & Bettendorff, L. (2020). Dibenzoylthiamine has powerful antioxidant and anti-inflammatory properties in cultured cells and in mouse models of stress and neurodegeneration. Biomedicines, 8, 361. doi:10.3390/biomedicines8090361
Peer Reviewed verified by ORBi

Gilsoul, M., Medard, L., Coumans, B., Delgado-Escueta, A., de Nijs, L., & Lakaye, B. (July 2018). EFHC1, a protein mutated in Juvenile Myoclonic Epilepsy, interacts with TTLL6 and modulates the level of tubulin polyglutamylation [Poster presentation]. FENS - 11th edition, Berlin, Germany.

Gilsoul, M., Coumans, B., Delgado-Escueta, A., & de Nijs, L. (08 June 2018). The role of intestinal cell kinase in interneurons, a protein mutated in Juvenile Myoclonic Epilepsy [Poster presentation]. Bscdb - Spring 2018, Liège, Belgium.

Nganou, G., Tanaka, M., Coumans, B. (Other coll.), Gomes Da Silva, C. (Other coll.), Grisar, T. (Other coll.), De Nijs, L. (Other coll.), Delgado Escueta, A. V. (Other coll.), & Lakaye, B. (Other coll.). (27 April 2017). Importin-8 could cause CAE/JME by delaying early neuroblast migration [Poster presentation]. 2nd Joint SFBD/SBCF Meeting : When Development meets Cell Biology, Lyon, France.

Vignisse, J., Sambon, M., Gorlova, A., Pavlov, D., Caron, N., Malgrange, B., Shevtsova, E., Svistunov, A., Anthony, D. C., Markova, N., Bazhenova, N., Coumans, B., Lakaye, B., Wins, P., Strekalova, T., & Bettendorff, L. (2017). Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Molecular and Cellular Neuroscience, 82, 126-136. doi:10.1016/j.mcn.2017.05.005
Peer Reviewed verified by ORBi

Nganou, G., Coumans, B., De Nijs, L., & Lakaye, B. (06 December 2016). Implication of Importin-8 in mouse brain development [Poster presentation]. American Society for Cell Biology, San Francisco, United States.

Nganou, G., Tanaka, M., Coumans, B., GRISAR, T., De Nijs, L., Delgado-Escueta, A., & Lakaye, B. (December 2016). Importin-8 mutations could cause Jeavons Syndrome, CAE and JME by altering early neuroblast migration [Poster presentation]. American Epilepsy Society, Houston (TEXAS), United States.

Nganou, G., Denijs, L., Lakaye, B., & Coumans, B. (Other coll.). (08 October 2016). Implication of Importin-8 in mouse brain development [Poster presentation]. 6th Belgian Brain Congress, Mons, Belgium. doi:10.3389/conf.fnagi.2016.03.00037

Medard, L., Coumans, B., Lakaye, B., De Nijs, L., & Godin, J. (Other coll.). (June 2016). Myoclonin-1 modulates the post-translational modification of microtubules [Poster presentation]. EMBO | EMBL Symposium: Microtubules: From Atoms to Complex Systems, Heidelberg, Germany.

Medard, L., Godin, J. (Other coll.), Coumans, B. (Other coll.), GRISAR, T. (Other coll.), Delgado-Escueta, A. (Other coll.), Lakaye, B. (Other coll.), & de Nijs, L. (Other coll.). (December 2015). EFHC1/Myoclonin-1 modulates the post-translational modification of microtubules [Poster presentation]. 69th Annual Meeting American Epilepsy Society, Philadelphie, United States.

Medard, L., Lakaye, B., Godin, J. (Other coll.), Coumans, B. (Other coll.), & de Nijs, L. (Other coll.). (2015). Myoclonin 1 modulates the post-translational modification of microtubules [Poster presentation]. BSCDB SPRING MEETING 2015, Liège, Belgium.

de Nijs, L., Wolkoff, N., Coumans, B., Delgado-Escueta, A., Grisar, T., & Lakaye, B. (2012). Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt radial and tangential migrations during brain development. Human Molecular Genetics, 21 (23), 5106-17. doi:10.1093/hmg/dds356
Peer Reviewed verified by ORBi

Lakaye, B., Coumans, B., Harray, S., & Grisar, T. (2009). Melanin-concentrating hormone and immune function. Peptides, 30, 2076-80. doi:10.1016/j.peptides.2009.05.004
Peer Reviewed verified by ORBi

Coumans, B., Grisar, T., Nahon, J. L., & Lakaye, B. (04 October 2007). Effect of ppMCH derived peptides on PBMC proliferation and cytokine expression. Regulatory Peptides, 143 (1-3), 104-108. doi:10.1016/j.regpep.2007.04.001
Peer Reviewed verified by ORBi

de Nijs, L., Lakaye, B., Coumans, B., Leon, C., Ikeda, T., Delgado-Escueta, A. V., Grisar, T., & Chanas, G. (10 September 2006). EFHC1, a protein mutated in juvenile myoclonic epilepsy, associates with the mitotic spindle through its N-terminus. Experimental Cell Research, 312 (15), 2872-2879. doi:10.1016/j.yexcr.2006.05.011
Peer Reviewed verified by ORBi

Grisar, T., de Nijs, L., Chanas, G., Leon, C., Coumans, B., Foidart, A., & Lakaye, B. (2006). Some genetic and biochemical aspects of myoclonus. Neurophysiologie Clinique, 36 (5-6, Sep-Dec), 271-279. doi:10.1016/j.neucli.2006.11.002
Peer Reviewed verified by ORBi

Adamantidis, A., Thomas, E., Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., & Lakaye, B. (15 November 2005). Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive and NMDA response deficit. Journal of the Neurological Sciences, 238 (Suppl. 1), 288.
Peer Reviewed verified by ORBi

Szyniarowski, P., Lakaye, B., Czerniecki, J., Makarchikov, A. F., Wins, P., Margineanu, I., Coumans, B., Grisar, T., & Bettendorff, L. (2005). Pig tissues express a catalytically inefficient 25-kDa thiamine triphosphatase: Insight in the catalytic mechanisms of this enzyme. Biochimica et Biophysica Acta - General Subjects, 1725 (1), 93-102. doi:10.1016/j.bbagen.2005.05.026
Peer Reviewed verified by ORBi

Adamantidis, A., Thomas, E., Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., & Lakaye, B. (2005). Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. European Journal of Neuroscience, 21 (10), 2837-44. doi:10.1111/j.1460-9568.2005.04100.x
Peer Reviewed verified by ORBi

Lakaye, B., Adamantidis, A., Coumans, B., & Grisar, T. (16 April 2004). Promoter characterization of the mouse melanin-concentrating hormone receptor 1. Biochimica et Biophysica Acta-Gene Structure and Expression, 1678 (1), 1-6. doi:10.1016/j.bbaexp.2004.01.006
Peer Reviewed verified by ORBi

Lakaye, B., Makarchikov, A. F., Wins, P., Margineanu, I., Roland, S., Lins, L., Aichour, R., Lebeau, L., Elmoualij, B., Zorzi, W., Coumans, B., Grisar, T., & Bettendorff, L. (2004). Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. International Journal of Biochemistry and Cell Biology, 36 (7), 1348-1364. doi:10.1016/j.biocel.2003.11.013
Peer Reviewed verified by ORBi

Makarchikov, A. F., Lakaye, B., Gulyai, I. E., Czerniecki, J., Coumans, B., Wins, P., Grisar, T., & Bettendorff, L. (2003). Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cellular and Molecular Life Sciences, 60 (7), 1477-1488. doi:10.1007/s00018-003-3098-4
Peer Reviewed verified by ORBi

Verlaet, M., Adamantidis, A., Coumans, B., Chanas, G., Zorzi, W., Heinen, E., Grisar, T., & Lakaye, B. (11 September 2002). Human immune cells express ppMCH mRNA and functional MCHR1 receptor. FEBS Letters, 527 (1-3), 205-210. doi:10.1016/S0014-5793(02)03232-5
Peer Reviewed verified by ORBi

Lakaye, B., Makarchikov, A. F., Antunes, A. F., Zorzi, W., Coumans, B., De Pauw, E., Wins, P., Grisar, T., & Bettendorff, L. (2002). Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. Journal of Biological Chemistry, 277 (16), 13771-13777. doi:10.1074/jbc.M111241200
Peer Reviewed verified by ORBi

Thellin, O., Coumans, B., Zorzi, W., Igout, A., & Heinen, E. (December 2000). Tolerance to the Foeto-Placental 'Graft': Ten Ways to Support a Child for Nine Months. Current Opinion in Immunology, 12 (6), 731-7. doi:10.1016/S0952-7915(00)00170-9
Peer Reviewed verified by ORBi

Antoine, N., Cesbron, J. Y., Coumans, B., Jolois, O., Zorzi, W., & Heinen, E. (May 2000). Differential Expression of Cellular Prion Protein on Human Blood and Tonsil Lymphocytes. Haematologica, 85 (5), 475-80.
Peer Reviewed verified by ORBi

Thellin, O., Coumans, B., Devos, S., Hooghe-Peters, E. L., Zorzi, W., Igout, A., Heinen, E., & Hooghe, R. (2000). Limited effects of placental and pituitary growth hormone on cytokine expression in vitro. European Cytokine Network, 11 (3), 452-455.
Peer Reviewed verified by ORBi

Thellin, O., Zorzi, W., Lakaye, B., De Borman, B., Coumans, B., Hennen, G., Grisar, T., Igout, A., & Heinen, E. (1999). Housekeeping Genes as Internal Standards: Use and Limits. Journal of Biotechnology, 75 (2-3), 291-5. doi:10.1016/S0168-1656(99)00163-7
Peer Reviewed verified by ORBi

Coumans, B., Thellin, O., Zorzi, W., Mélot, F., Bougoussa, M., Melen-Lamalle, L., Zorzi, D., Hennen, G., Igout, A., & Heinen, E. (1999). Lymphoid cell apoptosis induced by trophoblastic cells: a model of active foeto-placental tolerance. Journal of Immunological Methods, 224 (1-2), 185-196. doi:10.1016/S0022-1759(99)00021-6
Peer Reviewed verified by ORBi

Thellin, O., Coumans, B., Zorzi, W., Mélot, F., HENNEN, G., Igout, A., & Heinen, E. (21 November 1998). Possible intervention of hPGH in the human fœtal tolerance through Th1/Th2 balance ? [Poster presentation]. 170ième réunion de la Société Belge de Biochimie et de Biologie Moléculaire, Gent, Belgium.

Zahedi, S., Legrand, R., Brunel, G., Albert, A., Dewé, W., Coumans, B., & Bernard, J. P. (November 1998). Evaluation of a Diphenylphosphorylazide-Crosslinked Collagen Membrane for Guided Bone Regeneration in Mandibular Defects in Rats. Journal of Periodontology, 69 (11), 1238-46. doi:10.1902/jop.1998.69.11.1238
Peer Reviewed verified by ORBi

Zorzi, W., Thellin, O., Coumans, B., Mélot, F., Hennen, G., Lakaye, B., Igout, A., & Heinen, E. (1998). Demonstration of the expression of CD95 ligand transcript and protein in human placenta. Placenta, 19 (4), 269-277. doi:10.1016/S0143-4004(98)90058-3
Peer Reviewed verified by ORBi

Coumans, B., Thellin, O., Zorzi, W., Melen, L., Mélot, F., Bougoussa, M., Zorzi, D., HENNEN, G., & Igout, A. (1998). The influence of placental growth hormone on cell proliferation [Poster presentation]. meeting annuel de la Belgian Immunological Society.

Thellin, O., Coumans, B., Zorzi, W., Barnard, R., Hennen, G., Heinen, E., & Igout, A. (1998). Expression of Growth Hormone Receptors by Lymphocyte Subpopulations in the Human Tonsil. Developmental Immunology, 6 (3-4), 295-304. doi:10.1155/1998/85209
Peer Reviewed verified by ORBi

Thellin, O., Coumans, B., Zorzi, W., Mélen, L., Mélot, F., Bougoussa, M., Zorzi, D., HENNEN, G., Igout, A., & Heinen, E. (1998). Effects of growth hormones on cytokine synthesis by immune cells [Poster presentation]. meeting annuel de la Belgian Immunological Society.

Thellin, O., Coumans, B., Zorzi, W., Melen, L., Foidart, J.-M., Igout, A., & Heinen, E. (October 1997). The Placental Growth Hormone is Biologically Active [Paper presentation]. First Conference on Hormones, Blood Cells and Immunity, Obernai, France.

Thellin, O., Coumans, B., Zorzi, W., Melen, L., Foidart, J.-M., Igout, A., & Heinen, E. (1997). The Placental Growth Hormone is Biologically Active [Poster presentation]. First Conference on Hormones, Blood Cells and Immunity, Obernai, France.

Coumans, B., Thellin, O., Zorzi, W., Igout, A., & Heinen, E. (1997). The Expression of the Pituitary Growth Hormone Receptors by Blood Mononuclear Cells Can Be Modulated [Poster presentation]. First Conference on Hormones, Blood Cells and Immunity, Obernai, France.

Thellin, O., Coumans, B., Zorzi, W., Mélot, F., Melen, L., Zorzi, D., Barnard, R., Igout, A., & Heinen, E. (1996). Cytometric detection of the human growth hormone receptor [Poster presentation]. 12th Germinal Center Conference.

Thellin, O., Coumans, B., Zorzi, W., Mélot, F., Melen, L., Zorzi, D., Bernard, R., Igout, A., & Heinen, E. (1996). Expression of growth hormone receptors by human lymphoid cells in the tonsillar lymph follicules [Poster presentation]. meeting annuel de la Belgian Immunological Society.

Thellin, O., Coumans, B., Mélot, F., Melen, L., Zorzi, D., Igout, A., & Heinen, E. (1995). Expression of growth hormone receptors by normal or pathological human lymphoid cells [Poster presentation]. meeting annuel de la Belgian Immunological Society.

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