Article (Scientific journals)
Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
Muto, Vincenzo; Koshmanova, Ekaterina; Ghaemmaghami Tabrizi, Pouya et al.
2021In Sleep, 44 (1), p. 137
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Keywords :
Alzheimer’s disease; daytime sleepiness; polygenic risk scores; slow wave energy; sleep
Abstract :
[en] Study objectives: Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer's disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. Methods: We computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation and extended sleep opportunity, in a carefully selected homogenous sample of healthy 363 young men (22.1 y ± 2.7) devoid of sleep and cognitive disorders. Results: AD PRS was associated with more slow wave energy, i.e. the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with large slow wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness. Conclusions: These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.
Disciplines :
Genetics & genetic processes
Author, co-author :
Muto, Vincenzo   ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
Koshmanova, Ekaterina  ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
Ghaemmaghami Tabrizi, Pouya  
Jaspar, Mathieu 
Meyer, Christelle 
Elansary, Mahmoud 
Van Egroo, Maxime 
Chylinski, Daphné 
Berthomier, Christian
Brandewinder, Marie
Archer, Simon N
Yengo, Loic
Byrne, Enda
Dijk, Derk-Jan
Visscher, Peter M
More authors (18 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
Publication date :
16 July 2021
Journal title :
Sleep
ISSN :
0161-8105
eISSN :
1550-9109
Publisher :
The American Academy of Sleep Medicine, United States - Illinois
Volume :
44
Issue :
1
Pages :
zsaa137
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 July 2020

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