[en] Pancreas ductal adenocarcinoma is one of the deadliest cancers where surgery remains the main survival factor. Mitochondria were described to be involved in tumor aggressiveness in several cancer types including pancreas cancer. We have previously reported that myoferlin controls mitochondrial structure and function, and demonstrated that myoferlin depletion disturbs the mitochondrial dynamics culminating to a mitochondrial fission. In order to unravel the mechanism underlying this observation, we explored the myoferlin localization in pancreatic cancer cells and showed a colocalization with the mitochondrial dynamic machinery element: mitofusin. This colocalization was confirmed in several pancreas cancer cell lines and in normal cell lines as well. Moreover, in pancreas cancer cell lines, it appeared that myoferlin interacted with mitofusin. These discoveries open-up new research avenue aiming at modulating mitofusin function in pancreas cancer.
Research center :
Giga-Cancer - ULiège CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Oncology
Author, co-author :
Anania, Sandy ; Université de Liège - ULiège > Cancer-Metastases Research Laboratory
Peiffer, Raphaël ; Université de Liège - ULiège > Master sc. bioméd., à fin.
Rademaker, Gilles ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Thiry, Marc ; Université de Liège - ULiège > Département des sciences de la vie > Biologie cellulaire
Deldicque, Louise; Université Catholique de Louvain - UCL
Francaux, Marc; Université Catholique de Louvain - UCL
Maloujahmoum, Naïma ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Agirman, Ferman ; Université de Liège - ULiège > Cancer-Metastases Research Laboratory
Bellahcene, Akeila ; Université de Liège - ULiège > Cancer-Metastases Research Laboratory
Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Peulen, Olivier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Myoferlin is a yet unknown interactor of the mitochondrial dynamics’ machinery in pancreas cancer cells
Publication date :
21 June 2020
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland
Volume :
12
Issue :
6
Pages :
1643
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE] Fonds Léon Fredericq [BE] ULiège - Université de Liège [BE]
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